Page last updated: 2024-10-17

lactic acid and Foreign-Body Granuloma

lactic acid has been researched along with Foreign-Body Granuloma in 29 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
" OBJECTIVE To review the use of injectable PLLA, specifically regarding optimal injection technique that can reduce adverse events (AEs) and enhance out comes."2.44Minimizing adverse events associated with poly-L-lactic acid injection. ( Narins, RS, 2008)
" Recent evidence shows that local/regional/systemic delayed adverse effects may appear with its use."1.35Late-onset immune-mediated adverse effects after poly-L-lactic acid injection in non-HIV patients: clinical findings and long-term follow-up. ( Alijotas-Reig, J; Garcia-Gimenez, V; Vilardell-Tarres, M, 2009)
"For the glabellar region, severe partly vascular adverse events have been reported after treatment with injectable fillers."1.35The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. ( Bachmann, F; Erdmann, R; Hartmann, V; Rzany, B; Wiest, L, 2009)
"Polylactic acid (PLA) is an agent that is injected with the aim of enhancing the host's own collagen deposition."1.34Adverse reactions to polylactic acid injections in the periorbital area. ( Apikian, M; Goodman, GJ; Roberts, S, 2007)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (6.90)18.2507
2000's22 (75.86)29.6817
2010's5 (17.24)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ledon, JA1
Savas, JA1
Yang, S1
Franca, K1
Camacho, I1
Nouri, K1
Fuller, ML1
Bradley, EA1
Narins, RS1
Reszko, AE1
Sadick, NS1
Magro, CM1
Farber, J1
Beer, K1
Bentkover, SH1
Curcio, NM1
Parish, LC1
Azizzadeh, B2
Alijotas-Reig, J1
Garcia-Gimenez, V1
Vilardell-Tarres, M1
Bachmann, F1
Erdmann, R1
Hartmann, V1
Wiest, L1
Rzany, B1
Luginbuehl, V1
Ruffieux, K1
Hess, C1
Reichardt, D1
von Rechenberg, B1
Nuss, K1
Avery, C1
Clifford, N1
Schuller-Petrović, S1
Pavlović, MD1
Schuller, SS1
Schuller-Lukić, B1
Neuhold, N1
Lombardi, T1
Samson, J1
Plantier, F1
Husson, C1
Küffer, R1
Dijkema, SJ1
van der Lei, B1
Kibbelaar, RE1
Oppel, T1
Schaller, M1
Flaig, M1
Korting, HC1
Poveda, R1
Bagán, JV1
Murillo, J1
Jiménez, Y1
Andre, P1
Lowe, NJ1
Parc, A1
Clerici, TH1
Zimmermann, U1
Bauer, U1
Vleggaar, D1
Lam, SM1
Graivier, M1
Wildemore, JK1
Jones, DH1
Wolfram, D1
Tzankov, A1
Piza-Katzer, H1
Spoliti, M1
Apikian, M1
Roberts, S1
Goodman, GJ1
Dionyssopoulos, A1
Nikolis, A1
Patsatsi, A1
Sotiriadis, D1
Vieu, C1
Arnault, JP1
Petitpain, N1
Cuny, JF1
Barbaud, A1
Plenat, F1
Schmutz, JL1
Goldan, O1
Garbov-Nardini, G1
Regev, E1
Orenstein, A1
Winkler, E1
Gould, L1
Trope, G1
Cheng, YL1
Heathcote, JG1
Sheardown, H1
Rootman, D1
Liu, GS1
Menon, IA1
Suuronen, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Split-face Study of Changing in Skin Physiology and Clinical Appearance After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces[NCT02312154]Phase 425 participants (Actual)Interventional2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Elasticity

"We measured a elasticity by a reviscometer device (Courage & Khazaka, Cologne, Germany).~The range of elasticity was 0 (most elastic possible as) ~400 AU(Arbitrary Unit) (inelastic as possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)242.33
Untreated Side271.15

Erythema Index

"We measured an erythema index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of erythema index is 0~999 AU(Arbitrary Unit). The range of erythema index was 0 (as non-erythematous as possible) ~999 AU (most erythematous possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)253.66
Untreated Side243.53

Global Aesthetic Improvement Scale (Investigator)

The therapeutic outcome was assessed by investigator using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse. (NCT02312154)
Timeframe: 12 weeks

Interventionscores on a scale (Mean)
Treated Side (Restylane Vital)1.38
Untreated Side0

Global Aesthetic Improvement Scale (Subject)

The therapeutic outcome was assessed by patient self-assessment using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse (NCT02312154)
Timeframe: 12 weeks

Interventionscores on a scale (Mean)
Treated Side (Restylane Vital)1.33
Untreated Side0

Hydration Level

"We measured a hydration level by a corneometer device (Courage & Khazaka, Cologne, Germany).~The range of hydration level was 0 (as dry as possible) ~120 AU (Arbitrary Unit)(most moist possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)53.19
Untreated Side46.75

Melanin Index

"We measured a melanin index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of melanin index was 0 (as bright as possible) ~999 AU (Arbitrary Unit) (most dark possible)." (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)147.25
Untreated Side149.00

Reviews

4 reviews available for lactic acid and Foreign-Body Granuloma

ArticleYear
Inflammatory nodules following soft tissue filler use: a review of causative agents, pathology and treatment options.
    American journal of clinical dermatology, 2013, Volume: 14, Issue:5

    Topics: Acrylic Resins; Adipose Tissue; Biocompatible Materials; Collagen; Dermatologic Agents; Durapatite;

2013
Minimizing adverse events associated with poly-L-lactic acid injection.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2008, Volume: 34 Suppl 1

    Topics: Cellulose; Cosmetic Techniques; Drug Compounding; Face; Female; Granuloma, Foreign-Body; HIV-Associa

2008
Adverse reactions to dermal fillers: a review of European experiences.
    Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology, 2005, Volume: 7, Issue:3-4

    Topics: Acrylates; Acrylic Resins; Biocompatible Materials; Cellulose; Collagen; Cosmetic Techniques; Drug E

2005
Biodegradable fracture-fixation devices in maxillofacial surgery.
    International journal of oral and maxillofacial surgery, 1993, Volume: 22, Issue:1

    Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Plates; Bone Screws; Fracture

1993

Other Studies

25 other studies available for lactic acid and Foreign-Body Granuloma

ArticleYear
Facial Ulcers and Restrictive Strabismus From Delayed Periorbital Granuloma After Poly-L-Lactic Acid Injection.
    JAMA ophthalmology, 2015, Volume: 133, Issue:9

    Topics: Cosmetic Techniques; Face; Female; Granuloma, Foreign-Body; Humans; Injections, Intradermal; Lactic

2015
Late-onset subcutaneous nodules after poly-L-lactic acid injection.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35 Suppl 1

    Topics: Cellulose; Collagen; Cosmetic Techniques; Female; Giant Cells, Foreign-Body; Granuloma, Foreign-Body

2009
Clinicopathologic correlation of delayed-onset periorbital poly-L-lactic acid nodules.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35 Suppl 1

    Topics: Cosmetic Techniques; Face; Female; Granuloma, Foreign-Body; Humans; Lactic Acid; Middle Aged; Polyes

2009
The biology of facial fillers.
    Facial plastic surgery : FPS, 2009, Volume: 25, Issue:2

    Topics: Animals; Biocompatible Materials; Biofilms; Cattle; Chondrogenesis; Collagen; Cosmetic Techniques; D

2009
Injectable fillers: an American perspective.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2009, Volume: 144, Issue:3

    Topics: Acrylic Resins; Animals; Biocompatible Materials; Cattle; Collagen; Cosmetic Techniques; Dermatologi

2009
Late-onset infections and granuloma formation after facial polylactic acid (new-fill) injections in women who are heavy smokers.
    Plastic and reconstructive surgery, 2009, Volume: 124, Issue:1

    Topics: Bacterial Infections; Cellulose; Cosmetic Techniques; Female; Granuloma, Foreign-Body; Humans; Injec

2009
Late-onset immune-mediated adverse effects after poly-L-lactic acid injection in non-HIV patients: clinical findings and long-term follow-up.
    Dermatology (Basel, Switzerland), 2009, Volume: 219, Issue:4

    Topics: Adult; Aged; Biocompatible Materials; Cohort Studies; Cosmetic Techniques; Edema; Face; Female; Foll

2009
The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35 Suppl 2

    Topics: Adult; Aged; Aged, 80 and over; Biocompatible Materials; Cicatrix; Dermatologic Agents; Drug Combina

2009
Controlled release of tetracycline from biodegradable beta-tricalcium phosphate composites.
    Journal of biomedical materials research. Part B, Applied biomaterials, 2010, Volume: 92, Issue:2

    Topics: Absorbable Implants; Animals; Anti-Bacterial Agents; Biocompatible Materials; Calcium Phosphates; Ce

2010
Foreign body granulomatous reaction of the temporal region following dermal filler administration.
    The British journal of oral & maxillofacial surgery, 2010, Volume: 48, Issue:6

    Topics: Cosmetic Techniques; Female; Granuloma, Foreign-Body; Humans; Injections, Intradermal; Lactic Acid;

2010
Early granulomatous foreign body reactions to a novel alginate dermal filler: the system's failure?
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2013, Volume: 27, Issue:1

    Topics: Adult; Alginates; Cellulose; Cosmetic Techniques; Dermatologic Agents; Esthetics; Female; Follow-Up

2013
Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2004, Volume: 33, Issue:2

    Topics: Acrylates; Adult; Aged; Aged, 80 and over; Cellulose; Collagen; Cosmetic Techniques; Face; Female; G

2004
New-fill injections may induce late-onset foreign body granulomatous reaction.
    Plastic and reconstructive surgery, 2005, Apr-15, Volume: 115, Issue:5

    Topics: Adult; Cellulose; Cheek; Cosmetic Techniques; Female; Granuloma, Foreign-Body; Humans; Lactic Acid;

2005
[Facial foreign body granulomas after dermal injection of a polylactate-based implant for wrinkles].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2003, Volume: 1, Issue:3

    Topics: Facial Dermatoses; Female; Granuloma, Foreign-Body; Humans; Lactic Acid; Middle Aged; Polyesters; Po

2003
Granulomatous facial reaction to injected cosmetic fillers--a presentation of five cases.
    Medicina oral, patologia oral y cirugia bucal, 2006, Jan-01, Volume: 11, Issue:1

    Topics: Aged; Animals; Anti-Inflammatory Agents; Cattle; Collagen; Cosmetic Techniques; Face; Female; Granul

2006
Response to "New-fill injections may induce late-onset foreign body granulomatous reaction".
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:1

    Topics: Cellulose; Cosmetic Techniques; Granuloma, Foreign-Body; Humans; Lactic Acid; Mannitol; Polymers; Pr

2006
Injectable poly-L-lactic acid (Sculptra): technical considerations in soft-tissue contouring.
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:3 Suppl

    Topics: Adult; Aged; Biocompatible Materials; Cellulose; Cheek; Cosmetic Techniques; Face; Female; Freeze Dr

2006
Persistent granulomatous inflammatory response induced by injectable poly-L-lactic acid for HIV lipoatrophy.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006, Volume: 32, Issue:11

    Topics: Biocompatible Materials; Diagnosis, Differential; Face; Granuloma, Foreign-Body; HIV-Associated Lipo

2006
Surgery for foreign body reactions due to injectable fillers.
    Dermatology (Basel, Switzerland), 2006, Volume: 213, Issue:4

    Topics: Acrylates; Adult; Biocompatible Materials; Cellulose; Collagen; Cosmetic Techniques; Facial Dermatos

2006
Glenoid osteolysis after arthroscopic labrum repair with a bioabsorbable suture anchor.
    Acta orthopaedica Belgica, 2007, Volume: 73, Issue:1

    Topics: Absorbable Implants; Adult; Arthroscopy; Athletic Injuries; Female; Follow-Up Studies; Granuloma, Fo

2007
Adverse reactions to polylactic acid injections in the periorbital area.
    Journal of cosmetic dermatology, 2007, Volume: 6, Issue:2

    Topics: Cellulose; Cosmetic Techniques; Dermatologic Agents; Face; Female; Granuloma, Foreign-Body; Humans;

2007
Granulomas of the lips: a rare complication after injection of polylactic acid for aesthetic augmentation.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2007, Volume: 60, Issue:9

    Topics: Cosmetic Techniques; Female; Granuloma, Foreign-Body; Humans; Lactic Acid; Lip Diseases; Middle Aged

2007
[Granuloma at the injection site of leuprorelin acetate: foreign body reaction to polylactic acid].
    Annales de dermatologie et de venereologie, 2007, Volume: 134, Issue:10 Pt 1

    Topics: Aged; Buttocks; Granuloma, Foreign-Body; Humans; Injections, Intramuscular; Lactic Acid; Leuprolide;

2007
Late-onset infections and granuloma formation after facial polylactic acid (New-Fill) injections in women who are heavy smokers.
    Plastic and reconstructive surgery, 2008, Volume: 121, Issue:5

    Topics: Abscess; Drainage; Face; Female; Granuloma, Foreign-Body; Humans; Injections, Intradermal; Lactic Ac

2008
Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1994, Volume: 29, Issue:4

    Topics: Animals; Biocompatible Materials; Conjunctiva; Drug Delivery Systems; Fibrosis; Fluorouracil; Glycol

1994