lactic acid has been researched along with External Ophthalmoplegia in 11 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coenzyme Q10 (CoQ10) is frequently administered in mitochondrial diseases." | 5.10 | Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia. ( Hanisch, F; Zierz, S, 2003) |
| " Needle muscle biopsy specimens for biochemical measurement were obtained before and immediately after maximal short-term bicycle exercise test from 12 patients suffering from autosomal dominant and recessive forms of progressive external ophthalmoplegia and multiple deletions of mitochondrial DNA (adPEO, arPEO, respectively), five patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) 3243 A-->G point mutation, and four patients with McArdle's disease." | 3.71 | ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease. ( Härkönen, M; Lindholm, H; Löfberg, M; Majander, A; Näveri, H; Paetau, A; Somer, H; Sovijärvi, A; Suomalainen, A, 2001) |
| "Three patients with chronic progressive external ophthalmoplegia of adult-onset, generalized muscle atrophy and myalgia are described." | 1.29 | Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities. ( Gold, R; Klopstock, T; Naumann, M; Paulus, W; Reichmann, H; Reiners, K; Schindler, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nogueira, C | 1 |
| Marques, JS | 1 |
| Nesti, C | 1 |
| Azevedo, L | 1 |
| Di Lullo, M | 1 |
| Meschini, MC | 1 |
| Orlacchio, A | 1 |
| Santorelli, FM | 1 |
| Vilarinho, L | 1 |
| Lovadi, E | 1 |
| Csereklyei, M | 1 |
| Merkli, H | 1 |
| FüLöp, K | 1 |
| Sebők, Á | 1 |
| Karcagi, V | 1 |
| Komoly, S | 1 |
| Pál, E | 1 |
| Hanisch, F | 1 |
| Zierz, S | 1 |
| Lindholm, H | 2 |
| Löfberg, M | 2 |
| Somer, H | 2 |
| Näveri, H | 2 |
| Sovijärvi, A | 2 |
| Ferraris, S | 1 |
| Clark, S | 1 |
| Garelli, E | 1 |
| Davidzon, G | 1 |
| Moore, SA | 1 |
| Kardon, RH | 1 |
| Bienstock, RJ | 1 |
| Longley, MJ | 1 |
| Mancuso, M | 1 |
| Gutiérrez Ríos, P | 1 |
| Hirano, M | 1 |
| Copeland, WC | 1 |
| DiMauro, S | 1 |
| Lössner, J | 1 |
| Lehmann, W | 1 |
| Kühn, HJ | 1 |
| Ziegan, J | 1 |
| Brehme, M | 1 |
| Scarlato, G | 2 |
| Moggio, M | 2 |
| Fici, F | 1 |
| Cerri, C | 1 |
| Pellegrini, G | 1 |
| Ferini Strambi, L | 1 |
| Naumann, M | 1 |
| Reiners, K | 1 |
| Gold, R | 1 |
| Schindler, R | 1 |
| Paulus, W | 1 |
| Klopstock, T | 1 |
| Reichmann, H | 1 |
| Majander, A | 1 |
| Suomalainen, A | 1 |
| Paetau, A | 1 |
| Härkönen, M | 1 |
| Furuya, H | 1 |
| Motomura, S | 1 |
| Kitaguchi, T | 1 |
| Ishimoto, S | 1 |
| Goto, I | 1 |
2 trials available for lactic acid and External Ophthalmoplegia
| Article | Year |
|---|---|
Only transient increase of serum CoQ subset 10 during long-term CoQ10 therapy in mitochondrial ophthalmoplegia.
Topics: Adolescent; Adult; Aged; Antioxidants; Coenzymes; Female; Humans; Lactic Acid; Male; Middle Aged; Mi | 2003 |
Treatment of pyruvic and lactic acidaemia in ophthalmoplegia plus.
Topics: Acidosis; Biopsy; Clinical Trials as Topic; Electromyography; Humans; Lactates; Lactic Acid; Microsc | 1982 |
9 other studies available for lactic acid and External Ophthalmoplegia
| Article | Year |
|---|---|
Identification of maternal uniparental isodisomy of chromosome 10 in a patient with mitochondrial DNA depletion syndrome.
Topics: Brain; Chromosome Aberrations; Chromosomes, Human, Pair 10; DNA, Mitochondrial; Humans; Intestinal P | 2013 |
Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases.
Topics: Adult; Aged; Creatine Kinase; Disease Progression; DNA, Mitochondrial; Enzyme-Linked Immunosorbent A | 2017 |
Abnormal blood lactate accumulation after exercise in patients with multiple mitochondrial DNA deletions and minor muscular symptoms.
Topics: Adult; Case-Control Studies; DNA, Mitochondrial; Exercise; Female; Gene Deletion; Glycogen Storage D | 2004 |
Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.
Topics: Adult; Anemia, Macrocytic; Ataxia; Biopsy; Blotting, Southern; Cytochromes c; DNA Polymerase gamma; | 2008 |
[Ophthalmoplegia plus. On nosologic, biochemical, morphologic and computer tomographic aspects of the oculocraniosomatic syndrome].
Topics: Adult; Biopsy; Blepharoptosis; Brain Stem; Enzymes; Humans; Lactates; Lactic Acid; Male; Muscles; Ne | 1983 |
Metabolic effects of pyridoxine alpha-ketoglutarate in ophthalmoplegia plus.
Topics: Adolescent; Adult; Female; Humans; Lactates; Lactic Acid; Male; Mitochondria, Muscle; Ophthalmoplegi | 1982 |
Mitochondrial dysfunction in adult-onset myopathies with structural abnormalities.
Topics: Adult; Age of Onset; Creatine Kinase; Electron Transport Complex IV; Female; Humans; Hydrogen-Ion Co | 1995 |
ATP, phosphocreatine and lactate in exercising muscle in mitochondrial disease and McArdle's disease.
Topics: Adenosine Triphosphate; Adult; Aged; DNA, Mitochondrial; Electron Transport; Enzymes; Exercise; Exer | 2001 |
[A case of Kearns-Sayre-Shy syndrome with neuropathy and high lactate content in CSF].
Topics: Humans; Kearns-Sayre Syndrome; Lactates; Lactic Acid; Male; Middle Aged; Ophthalmoplegia; Peripheral | 1985 |