lactic acid has been researched along with Experimental Neoplasms in 77 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 7.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| "The aim of this study was to evaluate the ability of noninvasive 1H magnetic resonance spectroscopic imaging to detect the response of radiation-induced fibrosarcoma 1 tumors to treatment with 5-fluorouracil (5-FU)." | 3.70 | Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors. ( Aboagye, EO; Bhujwalla, ZM; Glickson, JD; Shungu, DC, 1998) |
| " Compared with the free EPB group, the NPs group exhibited higher plasma drug concentration, longer half-life time." | 1.46 | Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy. ( Chen, H; Li, Y; Lin, J; Lv, F; Nan, W; Tang, H; Wang, Y; Wei, X; Zhang, Q; Zhou, C; Zhu, W, 2017) |
| " However, an inadequate ablation dosage can leave a residual tumor or cause a variety of complications." | 1.43 | A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication. ( Cai, X; Chen, H; Chu, L; Gao, W; Li, P; Lu, G; Mei, Z; Ran, H; Song, J; Wang, R; Wang, Z; Xu, C; Yang, C; Zhang, N; Zheng, Y, 2016) |
| "Conversely, prostate cancer cells, upon contact with CAFs, were reprogrammed toward aerobic metabolism, with a decrease in GLUT1 expression and an increase in lactate upload via the lactate transporter MCT1." | 1.38 | Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. ( Chiarugi, P; Cirri, P; De Donatis, A; Fiaschi, T; Gandellini, P; Giannoni, E; Lanciotti, M; Marini, A; Serni, S; Taddei, ML, 2012) |
| "Neuroblastoma is a common childhood cancer that often results in progressive minimal residual disease after primary tumor resection." | 1.37 | Immunostimulatory sutures that treat local disease recurrence following primary tumor resection. ( Intra, J; Salem, AK; Sandler, AD; Williams, RL; Zhang, XQ; Zhu, X, 2011) |
| " Collectively, our observations reveal that nanoparticle-mediated delivery of phytochemicals could serve as a basis for enhancing bioavailability and limiting the unwanted toxicity of chemotherapeutic agents." | 1.37 | Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles. ( Bhatnagar, P; Gupta, KC; Kumar, P; Shukla, Y; Singh, M; Srivastava, AK, 2011) |
| "However, although most solid tumors maintain their intracellular pH (pHi) within a narrow range to provide a favorable environment for various intracellular activities, their extracellular pH (pHe) is on average about 0." | 1.30 | Causes and consequences of acidic pH in tumors: a magnetic resonance study. ( Griffiths, JR; McSheehy, PM; Stubbs, M, 1999) |
| " No clear toxic lesion was specifically caused by long-term administration of calcium lactate." | 1.28 | Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats. ( Hayashi, Y; Kodama, Y; Kurokawa, Y; Maekawa, A; Matsushima, Y; Onodera, H; Shibutani, M; Yoshida, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (10.39) | 18.7374 |
| 1990's | 17 (22.08) | 18.2507 |
| 2000's | 11 (14.29) | 29.6817 |
| 2010's | 40 (51.95) | 24.3611 |
| 2020's | 1 (1.30) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, QW | 1 |
| Wang, JW | 1 |
| Wang, XN | 1 |
| Fan, JX | 1 |
| Liu, XH | 1 |
| Li, B | 1 |
| Han, ZY | 1 |
| Cheng, SX | 1 |
| Zhang, XZ | 1 |
| Yang, Y | 2 |
| Wang, F | 1 |
| Zheng, K | 1 |
| Deng, L | 1 |
| Yang, L | 1 |
| Zhang, N | 2 |
| Xu, C | 2 |
| Ran, H | 2 |
| Wang, Z | 4 |
| Zheng, Y | 2 |
| Guan, J | 1 |
| Zhou, ZQ | 1 |
| Chen, MH | 2 |
| Li, HY | 1 |
| Tong, DN | 1 |
| Yang, J | 1 |
| Yao, J | 1 |
| Zhang, ZY | 1 |
| Xia, H | 1 |
| Wang, W | 1 |
| Crespo, J | 1 |
| Kryczek, I | 1 |
| Li, W | 1 |
| Wei, S | 1 |
| Bian, Z | 1 |
| Maj, T | 1 |
| He, M | 1 |
| Liu, RJ | 1 |
| He, Y | 1 |
| Rattan, R | 1 |
| Munkarah, A | 1 |
| Guan, JL | 1 |
| Zou, W | 1 |
| Milshteyn, E | 1 |
| von Morze, C | 1 |
| Reed, GD | 1 |
| Shang, H | 1 |
| Shin, PJ | 1 |
| Larson, PEZ | 1 |
| Vigneron, DB | 1 |
| Swales, JG | 1 |
| Dexter, A | 1 |
| Hamm, G | 1 |
| Nilsson, A | 1 |
| Strittmatter, N | 1 |
| Michopoulos, F | 1 |
| Hardy, C | 1 |
| Morentin-Gutierrez, P | 1 |
| Mellor, M | 1 |
| Andren, PE | 1 |
| Clench, MR | 1 |
| Bunch, J | 1 |
| Critchlow, SE | 1 |
| Goodwin, RJA | 1 |
| Tam, YT | 1 |
| Huang, C | 1 |
| Poellmann, M | 1 |
| Kwon, GS | 1 |
| Ohashi, T | 1 |
| Akazawa, T | 1 |
| Aoki, M | 1 |
| Kuze, B | 1 |
| Mizuta, K | 1 |
| Ito, Y | 1 |
| Inoue, N | 1 |
| Lim, KS | 1 |
| Lim, KJ | 1 |
| Price, AC | 1 |
| Orr, BA | 1 |
| Eberhart, CG | 1 |
| Bar, EE | 1 |
| Schmidt, R | 1 |
| Laustsen, C | 1 |
| Dumez, JN | 1 |
| Kettunen, MI | 1 |
| Serrao, EM | 1 |
| Marco-Rius, I | 1 |
| Brindle, KM | 2 |
| Ardenkjaer-Larsen, JH | 3 |
| Frydman, L | 1 |
| Wei, H | 1 |
| Xu, L | 2 |
| Sun, Y | 1 |
| Li, G | 1 |
| Cui, Z | 1 |
| Yan, G | 1 |
| Chen, Q | 2 |
| Yin, H | 1 |
| Ma, C | 1 |
| Yu, R | 1 |
| Zhao, H | 1 |
| Zhu, X | 2 |
| Yuan, H | 1 |
| Lan, M | 1 |
| Swami, A | 1 |
| Reagan, MR | 1 |
| Basto, P | 1 |
| Mishima, Y | 1 |
| Kamaly, N | 1 |
| Glavey, S | 1 |
| Zhang, S | 1 |
| Moschetta, M | 1 |
| Seevaratnam, D | 1 |
| Zhang, Y | 2 |
| Liu, J | 1 |
| Memarzadeh, M | 1 |
| Wu, J | 1 |
| Manier, S | 1 |
| Shi, J | 1 |
| Bertrand, N | 1 |
| Lu, ZN | 1 |
| Nagano, K | 1 |
| Baron, R | 1 |
| Sacco, A | 1 |
| Roccaro, AM | 1 |
| Farokhzad, OC | 1 |
| Ghobrial, IM | 1 |
| Li, Z | 1 |
| Li, J | 1 |
| Bi, P | 1 |
| Lu, Y | 2 |
| Burcham, G | 1 |
| Elzey, BD | 1 |
| Ratliff, T | 1 |
| Konieczny, SF | 1 |
| Ahmad, N | 1 |
| Kuang, S | 1 |
| Liu, X | 1 |
| Pemberton, RM | 1 |
| Cox, T | 1 |
| Tuffin, R | 1 |
| Drago, GA | 1 |
| Griffiths, J | 1 |
| Pittson, R | 1 |
| Johnson, G | 1 |
| Xu, J | 2 |
| Sage, IC | 1 |
| Davies, R | 1 |
| Jackson, SK | 1 |
| Kenna, G | 1 |
| Luxton, R | 1 |
| Hart, JP | 1 |
| Goodwin, ML | 1 |
| Jin, H | 1 |
| Straessler, K | 1 |
| Smith-Fry, K | 1 |
| Zhu, JF | 1 |
| Monument, MJ | 1 |
| Grossmann, A | 1 |
| Randall, RL | 1 |
| Capecchi, MR | 1 |
| Jones, KB | 1 |
| Bhatnagar, P | 2 |
| Patnaik, S | 1 |
| Srivastava, AK | 2 |
| Mudiam, MK | 1 |
| Shukla, Y | 2 |
| Panda, AK | 1 |
| Pant, AB | 1 |
| Kumar, P | 2 |
| Gupta, KC | 2 |
| Zhang, Z | 1 |
| Liu, S | 1 |
| Xiong, H | 1 |
| Jing, X | 1 |
| Xie, Z | 1 |
| Chen, X | 2 |
| Huang, Y | 1 |
| Liu, W | 1 |
| Wei, J | 1 |
| Wei, Y | 1 |
| Chen, Y | 1 |
| Wu, Y | 1 |
| Liu, G | 1 |
| Zeng, X | 1 |
| Wang, X | 2 |
| Gao, Y | 1 |
| Jiang, L | 1 |
| Shi, X | 1 |
| Tao, W | 1 |
| Huang, L | 1 |
| Mei, L | 1 |
| Gao, W | 1 |
| Wang, R | 1 |
| Chen, H | 2 |
| Cai, X | 1 |
| Lu, G | 1 |
| Chu, L | 1 |
| Li, P | 1 |
| Yang, C | 1 |
| Mei, Z | 1 |
| Song, J | 1 |
| Varma, G | 1 |
| Vinogradov, E | 1 |
| Bhatt, RS | 1 |
| Sukhatme, VP | 1 |
| Seth, P | 1 |
| Lenkinski, RE | 1 |
| Alsop, DC | 1 |
| Grant, AK | 1 |
| Li, WP | 1 |
| Su, CH | 1 |
| Chang, YC | 1 |
| Lin, YJ | 1 |
| Yeh, CS | 1 |
| Wang, J | 1 |
| Wright, AJ | 1 |
| Hu, DE | 1 |
| Hesketh, R | 1 |
| Dai, Y | 1 |
| Xing, H | 1 |
| Song, F | 1 |
| Qiu, Z | 1 |
| Lu, X | 1 |
| Liu, Q | 1 |
| Ren, S | 1 |
| Li, N | 1 |
| Durst, M | 2 |
| Koellisch, U | 1 |
| Daniele, V | 1 |
| Steiger, K | 1 |
| Schwaiger, M | 2 |
| Haase, A | 2 |
| Menzel, MI | 2 |
| Schulte, RF | 2 |
| Aime, S | 1 |
| Reineri, F | 1 |
| Nan, W | 1 |
| Wei, X | 1 |
| Wang, Y | 2 |
| Lv, F | 1 |
| Tang, H | 1 |
| Li, Y | 1 |
| Zhou, C | 1 |
| Lin, J | 1 |
| Zhu, W | 1 |
| Zhang, Q | 1 |
| Liang, C | 1 |
| Wang, C | 1 |
| Peng, R | 1 |
| Liu, Z | 1 |
| Liang, B | 1 |
| Zuo, GQ | 1 |
| Zheng, YY | 1 |
| He, S | 1 |
| Zuo, DY | 1 |
| Mao, J | 1 |
| Tang, S | 1 |
| Hong, D | 1 |
| Zhao, F | 1 |
| Niu, M | 1 |
| Han, X | 1 |
| Qi, J | 1 |
| Bao, H | 1 |
| Jiang, Y | 1 |
| Fu, C | 1 |
| Long, D | 1 |
| Meng, X | 1 |
| Su, H | 1 |
| Frank, H | 1 |
| Gröger, N | 1 |
| Diener, M | 1 |
| Becker, C | 1 |
| Braun, T | 1 |
| Boettger, T | 1 |
| Senthilkumar, M | 1 |
| Mishra, P | 1 |
| Jain, NK | 1 |
| Semenza, GL | 1 |
| Sonveaux, P | 1 |
| Végran, F | 1 |
| Schroeder, T | 1 |
| Wergin, MC | 1 |
| Verrax, J | 1 |
| Rabbani, ZN | 1 |
| De Saedeleer, CJ | 1 |
| Kennedy, KM | 1 |
| Diepart, C | 1 |
| Jordan, BF | 1 |
| Kelley, MJ | 1 |
| Gallez, B | 1 |
| Wahl, ML | 1 |
| Feron, O | 1 |
| Dewhirst, MW | 1 |
| de Groof, AJ | 1 |
| te Lindert, MM | 1 |
| van Dommelen, MM | 1 |
| Wu, M | 1 |
| Willemse, M | 1 |
| Smift, AL | 1 |
| Winer, M | 1 |
| Oerlemans, F | 1 |
| Pluk, H | 1 |
| Fransen, JA | 1 |
| Wieringa, B | 1 |
| Dominguez, AL | 1 |
| Lustgarten, J | 1 |
| Matoba, M | 1 |
| Kondou, T | 1 |
| Tanaka, T | 1 |
| Kitadate, M | 1 |
| Oota, K | 1 |
| Tonami, H | 1 |
| Intra, J | 1 |
| Zhang, XQ | 1 |
| Williams, RL | 1 |
| Sandler, AD | 1 |
| Salem, AK | 1 |
| Singh, M | 1 |
| Du, L | 1 |
| Jin, Y | 1 |
| Zhou, W | 1 |
| Zhao, J | 1 |
| Zhao, JH | 1 |
| Liu, Y | 1 |
| Feng, NP | 1 |
| Zhang, YT | 1 |
| Ma, W | 1 |
| Chen, M | 1 |
| Kaushal, S | 1 |
| McElroy, M | 1 |
| Ozkan, C | 1 |
| Bouvet, M | 1 |
| Kruse, C | 1 |
| Grotjahn, D | 1 |
| Ichim, T | 1 |
| Minev, B | 1 |
| Sperl, JI | 1 |
| Weidl, E | 1 |
| Janich, MA | 1 |
| Khegai, O | 1 |
| Glaser, SJ | 1 |
| Wiesinger, F | 1 |
| Fiaschi, T | 1 |
| Marini, A | 1 |
| Giannoni, E | 1 |
| Taddei, ML | 1 |
| Gandellini, P | 1 |
| De Donatis, A | 1 |
| Lanciotti, M | 1 |
| Serni, S | 1 |
| Cirri, P | 1 |
| Chiarugi, P | 1 |
| Guo, M | 1 |
| Ding, LY | 1 |
| Ron, WT | 1 |
| Liu, YQ | 1 |
| Song, FF | 1 |
| Yu, SQ | 1 |
| Zheng, N | 1 |
| Zhou, M | 1 |
| Lu, W | 1 |
| BRIN, M | 1 |
| Ahmed, S | 1 |
| Tsuchiya, T | 1 |
| Le Garrec, D | 1 |
| Gori, S | 1 |
| Luo, L | 1 |
| Lessard, D | 1 |
| Smith, DC | 1 |
| Yessine, MA | 1 |
| Ranger, M | 1 |
| Leroux, JC | 1 |
| Golman, K | 1 |
| Zandt, RI | 1 |
| Lerche, M | 1 |
| Pehrson, R | 1 |
| Weinberg, BD | 1 |
| Ai, H | 1 |
| Blanco, E | 1 |
| Anderson, JM | 1 |
| Gao, J | 1 |
| Sauer, LA | 1 |
| Blask, DE | 1 |
| Dauchy, RT | 1 |
| Burdon, RH | 1 |
| Kerr, SM | 1 |
| Cutmore, CM | 1 |
| Munro, J | 1 |
| Gill, V | 1 |
| Iwamoto, Y | 1 |
| Nishikawa, K | 1 |
| Yanai, S | 1 |
| Okada, H | 1 |
| Saito, K | 1 |
| Kuge, Y | 1 |
| Misaki, M | 1 |
| Ogawa, Y | 1 |
| Toguchi, H | 1 |
| Chance, WT | 2 |
| Thomas, I | 1 |
| Fischer, JE | 2 |
| Stratford, MR | 1 |
| Parkins, CS | 1 |
| Everett, SA | 1 |
| Dennis, MF | 1 |
| Stubbs, M | 2 |
| Hill, SA | 1 |
| Conlon, KC | 1 |
| Bading, JR | 1 |
| McDermott, EW | 1 |
| Corbally, MT | 1 |
| Tolvo, AJ | 1 |
| Brennan, MF | 1 |
| Newell, K | 1 |
| Franchi, A | 1 |
| Pouysségur, J | 1 |
| Tannock, I | 1 |
| He, Q | 2 |
| Bhujwalla, ZM | 4 |
| Glickson, JD | 4 |
| Takada, S | 1 |
| Nagato, Y | 1 |
| Yamamura, M | 1 |
| Aboagye, EO | 2 |
| Shungu, DC | 1 |
| Egilmez, NK | 1 |
| Jong, YS | 1 |
| Iwanuma, Y | 1 |
| Jacob, JS | 1 |
| Santos, CA | 1 |
| Chen, FA | 1 |
| Mathiowitz, E | 1 |
| Bankert, RB | 1 |
| Yamagata, M | 1 |
| Hasuda, K | 1 |
| Stamato, T | 1 |
| Tannock, IF | 1 |
| McSheehy, PM | 1 |
| Griffiths, JR | 1 |
| van Es, RJ | 1 |
| Nijsen, JF | 1 |
| Dullens, HF | 1 |
| Kicken, M | 1 |
| van der Bilt, A | 1 |
| Hennink, W | 1 |
| Koole, R | 1 |
| Slootweg, PJ | 1 |
| Hurd, RE | 2 |
| Freeman, D | 1 |
| Constantinidis, I | 1 |
| Chatham, JC | 1 |
| Wehrle, JP | 1 |
| Krüger, W | 1 |
| Mayer, WK | 1 |
| Schaefer, C | 1 |
| Stohrer, M | 1 |
| Vaupel, P | 1 |
| Maekawa, A | 1 |
| Matsushima, Y | 1 |
| Onodera, H | 1 |
| Shibutani, M | 1 |
| Yoshida, J | 1 |
| Kodama, Y | 1 |
| Kurokawa, Y | 1 |
| Hayashi, Y | 1 |
| Freeman, DM | 1 |
| Sotak, CH | 2 |
| Muller, HH | 1 |
| Young, SW | 1 |
| Carlsson, J | 1 |
| Acker, H | 1 |
| Inculet, RI | 1 |
| Peacock, JL | 1 |
| Gorschboth, CM | 1 |
| Norton, JA | 1 |
| Lyon, RC | 1 |
| Tschudin, RG | 1 |
| Daly, PF | 1 |
| Cohen, JS | 1 |
| Muggia-Sullam, M | 1 |
| Murphy, RF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Experimental Neoplasms
| Article | Year |
|---|---|
Dietary factors and growth and metabolism in experimental tumors.
Topics: Amino Acids; Animals; Blood Glucose; Dietary Fats, Unsaturated; Fish Oils; Humans; Ketone Bodies; La | 2007 |
76 other studies available for lactic acid and Experimental Neoplasms
| Article | Year |
|---|---|
Inhibition of Tumor Progression through the Coupling of Bacterial Respiration with Tumor Metabolism.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Humans; Hydrogen Peroxide; Hypoxia-In | 2020 |
Injectable PLGA/Fe3O4 implants carrying cisplatin for synergistic magnetic hyperthermal ablation of rabbit VX2 tumor.
Topics: Animals; Antineoplastic Agents; Cattle; Cisplatin; Drug Carriers; Ferrosoferric Oxide; In Vitro Tech | 2017 |
Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery.
Topics: A549 Cells; Animals; Citric Acid; Delayed-Action Preparations; Doxorubicin; HeLa Cells; Hep G2 Cells | 2017 |
Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Female; Gene Expression | 2017 |
Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized
Topics: Algorithms; Animals; Computer Simulation; Image Processing, Computer-Assisted; Lactic Acid; Magnetic | 2018 |
Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging.
Topics: Animals; Female; Glutamic Acid; Lactic Acid; Mass Spectrometry; Mice; Mice, Nude; Neoplasms, Experim | 2018 |
Stereocomplex Prodrugs of Oligo(lactic acid)
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deo | 2018 |
Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity.
Topics: Animals; Arginase; Cell Line, Tumor; Dichloroacetic Acid; Female; Glycolysis; Interferon-gamma; Inte | 2013 |
Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, | 2014 |
In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.
Topics: Algorithms; Animals; Echo-Planar Imaging; Kidney; Lactic Acid; Lymphoma; Magnetic Resonance Imaging; | 2014 |
Preliminary pharmacokinetics of PEGylated oxaliplatin polylactic acid nanoparticles in rabbits and tumor-bearing mice.
Topics: Animals; Drug Carriers; Lactic Acid; Mice; Nanoparticles; Neoplasms, Experimental; Organoplatinum Co | 2015 |
Three monofunctional copolymers into one multifunctional Micelle: Part 1. Preparation and properties.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Cell Line, Tumor; Crystallization; Endocytosis; La | 2014 |
Engineered nanomedicine for myeloma and bone microenvironment targeting.
Topics: Alendronate; Animals; Antineoplastic Agents; Bone Neoplasms; Boronic Acids; Bortezomib; Cell Line, T | 2014 |
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformati | 2014 |
Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers.
Topics: Biosensing Techniques; Cell Line, Tumor; Computer-Aided Design; Conductometry; Equipment Design; Equ | 2014 |
Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment.
Topics: Adolescent; Adult; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brain; Carr | 2014 |
Anti-cancer activity of bromelain nanoparticles by oral administration.
Topics: Administration, Oral; Antineoplastic Agents; Apoptosis; Bromelains; Cell Line, Tumor; Cell Survival; | 2014 |
Electrospun PLA/MWCNTs composite nanofibers for combined chemo- and photothermal therapy.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Survival; Combined Modality Therapy; Diffusion | 2015 |
Controlled Dual Drug Release and In Vitro Cytotoxicity of Electrospun Poly(lactic-co-glycolic acid) Nanofibers Encapsulated with Micelles.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brefeldin A; Delayed-Action Preparations; Diffusion; | 2015 |
Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cholic Acid; Diffusion; Female; Lactic Acid; Mice; | 2015 |
A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication.
Topics: Animals; Cattle; Cell Line, Tumor; Doxorubicin; Drug Implants; Humans; Hyperthermia, Induced; Iron; | 2016 |
Selective spectroscopic imaging of hyperpolarized pyruvate and its metabolites using a single-echo variable phase advance method in balanced SSFP.
Topics: A549 Cells; Alanine; Algorithms; Animals; Biomarkers, Tumor; Carbon Isotopes; Carbon-13 Magnetic Res | 2016 |
Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome.
Topics: Animals; Contrast Media; Drug Carriers; Ferrosoferric Oxide; HeLa Cells; Humans; Hydrogen Peroxide; | 2016 |
Single shot three-dimensional pulse sequence for hyperpolarized
Topics: Animals; Carbon Isotopes; Female; Imaging, Three-Dimensional; Lactic Acid; Magnetic Resonance Imagin | 2017 |
Biotin-Conjugated Multilayer Poly [D,L-lactide-co-glycolide]-Lecithin-Polyethylene Glycol Nanoparticles for Targeted Delivery of Doxorubicin.
Topics: Animals; Antibiotics, Antineoplastic; Biotin; Doxorubicin; Drug Delivery Systems; Endocytosis; Hep G | 2016 |
Probing lactate secretion in tumours with hyperpolarised NMR.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Lactic Acid; Magnetic Resonance Imaging; Male; Molecul | 2016 |
Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy.
Topics: Animals; Biotinylation; Chitosan; Drug Delivery Systems; Female; Lactic Acid; Mice; Neoplasms, Exper | 2017 |
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cells, Cultured; CTLA-4 A | 2016 |
[Clinical effect of ultrasound-guided injection of biodegradable poly(lactic-co-glycolic acid)-Fe
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cattle; Ferrosoferric Oxide; Glycolates; | 2016 |
Therapeutic efficacy of novel microwave-sensitized mPEG-PLGA@ZrO
Topics: Animals; Doxorubicin; Drug Carriers; Lactic Acid; Liver Neoplasms; Microspheres; Microwaves; Neoplas | 2017 |
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.
Topics: Animals; Butyrates; Carcinogens; Cation Transport Proteins; Cell Transformation, Neoplastic; Colon; | 2008 |
Long circulating PEGylated poly(D,L-lactide-co-glycolide) nanoparticulate delivery of Docetaxel to solid tumors.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Cell Line, Tumor; Chromatography, Gel; Docetaxel; | 2008 |
Tumor metabolism: cancer cells give and take lactate.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Drug Delivery Systems; Gene Expression Regulation, Neoplast | 2008 |
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Drug Delivery Systems; Gene Expression Regulation, Neoplast | 2008 |
Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype.
Topics: Adenovirus E1A Proteins; Animals; Cell Line, Transformed; Cell Proliferation; Cell Transformation, N | 2009 |
Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses.
Topics: Animals; Antibodies, Monoclonal; Cancer Vaccines; CD40 Antigens; Cell Line, Tumor; Cytokines; Immuno | 2010 |
Noninvasive monitoring of radiation-induced early therapeutic response using high-resolution MR imaging and proton MR spectroscopy in VX2 carcinoma.
Topics: Animals; Choline; Creatine; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2010 |
Immunostimulatory sutures that treat local disease recurrence following primary tumor resection.
Topics: Adjuvants, Immunologic; Animals; Biocompatible Materials; Cell Line, Tumor; Delayed-Action Preparati | 2011 |
Enhancement of cancer chemosensitization potential of cisplatin by tea polyphenols poly(lactide-co-glycolide) nanoparticles.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camellia sinensis; Cell Line, Tumor; Cell Survival; | 2011 |
Ultrasound-triggered drug release and enhanced anticancer effect of doxorubicin-loaded poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) nanodroplets.
Topics: Animals; Doxorubicin; Drug Carriers; Drug Delivery Systems; Female; Hydrogen-Ion Concentration; Lact | 2011 |
RGD-modified poly(D,L-lactic acid) nanoparticles enhance tumor targeting of oridonin.
Topics: Animals; Antineoplastic Agents; Diterpenes, Kaurane; Emulsions; Histocytochemistry; Lactic Acid; Mal | 2012 |
PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses.
Topics: Animals; Antigen Presentation; Antigens, Neoplasm; Cancer Vaccines; Cell Line, Tumor; Dendritic Cell | 2012 |
Saturation-recovery metabolic-exchange rate imaging with hyperpolarized [1-13C] pyruvate using spectral-spatial excitation.
Topics: Alanine; Animals; Bicarbonates; Carbon Isotopes; Cell Line, Tumor; Female; Lactic Acid; Magnetic Res | 2013 |
Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Fibroblasts; Gene Expression Regulati | 2012 |
Alpha-tocopheryl polyethylene glycol succinate-emulsified poly(lactic-co-glycolic acid) nanoparticles for reversal of multidrug resistance in vitro.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Resistance, Multiple; Drug R | 2012 |
In vivo distribution of 5-Fluorouracil after peritumoral implantation using a biodegradable micro-device in tumor-bearing mice.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Chromatography, High Pressure Liquid; Dr | 2013 |
The production of L (+) lactic acid by Ehrlich mouse ascites tumor cells.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Lactic Acid; Mice; Neoplasms, Experimental | 1953 |
Novel mechanism of tumorigenesis: increased transforming growth factor-beta 1 suppresses the expression of connexin 43 in BALB/cJ mice after implantation of poly-L-lactic acid.
Topics: Animals; Base Sequence; Biocompatible Materials; Cell Communication; Connexin 43; Female; Gap Juncti | 2004 |
Poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Female; Half-Life; Huma | 2004 |
Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.
Topics: Alanine; Animals; Carbon Isotopes; Lactic Acid; Magnetic Resonance Imaging; Male; Neoplasms, Experim | 2006 |
Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods.
Topics: Absorbable Implants; Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Doxorubicin; | 2007 |
Hyperthermia, Na+K+ATPase and lactic acid production in some human tumour cells.
Topics: Animals; Arsenic; Arsenites; Cell Line; Cell Membrane; Cells, Cultured; Cricetinae; Glycolysis; Heat | 1984 |
[Changes in lactic acid contents in metastatic liver tumors and normal liver tissues in rats following glucose administration into hepatic artery].
Topics: Animals; Glucose; Hepatic Artery; Injections, Intra-Arterial; Lactates; Lactic Acid; Liver; Liver Ne | 1982 |
Antitumor effect of arterial administration of a medium-chain triglyceride solution of an angiogenesis inhibitor, TNP-470, in rabbits bearing VX-2 carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Caprylates; Ca | 1995 |
Insulin reverses ammonia-induced anorexia and experimental cancer anorexia.
Topics: Ammonia; Animals; Anorexia; Blood Glucose; Dopamine; Eating; Glucagon; Hydroxyindoleacetic Acid; Hyp | 1994 |
Analysis of the acidic microenvironment in murine tumours by high-performance ion chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Ions; Lactates; Lactic Ac | 1995 |
Extremity metabolism in the cachectic, VX-2 carcinoma-bearing rabbit.
Topics: Amino Acids; Animals; Blood Glucose; Cachexia; Calcium; Eating; Extremities; Glucagon; Hematopoiesis | 1993 |
Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.
Topics: Aerobiosis; Anaerobiosis; Animals; Biological Transport; Cell Division; Cell Line, Transformed; Cell | 1993 |
Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer.
Topics: Animals; Choline; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; | 1996 |
Effect of cyclic polylactates on tumor cells and tumor bearing mice.
Topics: Anaerobiosis; Animals; Female; Glycolysis; L-Lactate Dehydrogenase; Lactic Acid; Mice; Mice, Inbred | 1997 |
Detection of tumor response to chemotherapy by 1H nuclear magnetic resonance spectroscopy: effect of 5-fluorouracil on lactate levels in radiation-induced fibrosarcoma 1 tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Fibrosarcoma; Fluorouracil; Humans; Lac | 1998 |
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter | 1998 |
Evaluation of lactate as a 1H nuclear magnetic resonance spectroscopy index for noninvasive prediction and early detection of tumor response to radiation therapy in EMT6 tumors.
Topics: Animals; Female; Humans; L-Lactate Dehydrogenase; Lactic Acid; Magnetic Resonance Spectroscopy; Mice | 1998 |
The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase.
Topics: Animals; Carbon Dioxide; CHO Cells; Cricetinae; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; | 1998 |
Causes and consequences of acidic pH in tumors: a magnetic resonance study.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Humans; Hydrogen-Ion Concentration; Lactic Acid; Mag | 1999 |
Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study.
Topics: Analysis of Variance; Animals; Brachytherapy; Dextrans; Embolization, Therapeutic; Extravasation of | 2001 |
Proton editing and imaging of lactate.
Topics: Animals; Hydralazine; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectros | 1991 |
Energy metabolism, pH changes, and lactate production in RIF-1 tumors following intratumoral injection of glucose.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Energy Metabolism; Female; Glucose; Guinea Pigs; Hyd | 1992 |
Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Combined Modality Th | 1991 |
Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Food Additives; Lactates; Lactic Acid; Male; Neop | 1991 |
A double quantum coherence transfer proton NMR spectroscopy technique for monitoring steady-state tumor lactic acid levels in vivo.
Topics: Animals; Female; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred Strains; | 1990 |
Relations between pH, oxygen partial pressure and growth in cultured cell spheroids.
Topics: Animals; Cell Division; Cell Line; Humans; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Lact | 1988 |
A volume-localized, two-dimensional NMR method for the determination of lactate using zero-quantum coherence created in a stimulated echo pulse sequence.
Topics: Animals; Lactates; Lactic Acid; Lipid Metabolism; Magnetic Resonance Spectroscopy; Mice; Models, Ana | 1988 |
Gluconeogenesis in the tumor-influenced rat hepatocyte: importance of tumor burden, lactate, insulin, and glucagon.
Topics: Amino Acids; Animals; Blood Glucose; Cachexia; Eating; Glucagon; Gluconeogenesis; Insulin; Lactates; | 1987 |
A versatile multinuclear probe designed for in vivo NMR spectroscopy: applications to subcutaneous human tumors in mice.
Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Glucose; Humans; In Vitro Techniques; Infant, Newborn; | 1988 |
Reversal of tumor-induced biochemical abnormalities by insulin treatment in rats.
Topics: Amino Acids; Animals; Anorexia; Blood Glucose; Body Weight; Eating; Glucagon; Gluconeogenesis; Insul | 1986 |