lactic acid has been researched along with Experimental Mammary Neoplasms in 38 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)." | 5.46 | Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017) |
| " Under conditions of acute hypoxia induced by breathing carbon monoxide at 660 ppm, the apparent glycolytic rate was 0." | 3.71 | Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy. ( Bentzen, L; Daugaard, P; Horsman, MR; Maxwell, RJ; Nielsen, FU; Overgaard, J; Stødkilde-Jørgensen, H, 2001) |
| "However, its role in breast cancer cell glucose metabolism was unclear." | 1.62 | Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021) |
| "4T1 murine breast cancer cells were transfected with shRNA plasmids directed against LDH-A (KD) or a scrambled control plasmid (NC)." | 1.48 | LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. ( Blasberg, R; Cohen, IJ; Khanin, R; Koutcher, JA; Maeda, M; Mane, M; Moroz, E; Satagopan, J; Serganova, I; Shindo, M; Vemuri, K, 2018) |
| "The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)." | 1.46 | Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017) |
| " Sustained release nanoparticles (NP) offer increased resistance to nuclease degradation, increased amounts of AS uptake, and the possibility of control in dosing and sustained duration of AS administration." | 1.36 | Biodistribution of antisense nanoparticles in mammary carcinoma rat model. ( Adwan, H; Berger, MR; Elazar, V; Golomb, G; Lifshitz-Shovali, R; Rohekar, K; Zepp, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.26) | 18.7374 |
| 1990's | 8 (21.05) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 18 (47.37) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, Y | 1 |
| Wang, J | 2 |
| Xu, Y | 1 |
| Wang, Y | 1 |
| Song, T | 1 |
| Liang, X | 1 |
| Jin, F | 1 |
| Su, D | 1 |
| Ben David-Naim, M | 1 |
| Grad, E | 1 |
| Aizik, G | 1 |
| Nordling-David, MM | 1 |
| Moshel, O | 1 |
| Granot, Z | 1 |
| Golomb, G | 2 |
| Peng, Y | 1 |
| Nie, J | 1 |
| Cheng, W | 1 |
| Liu, G | 1 |
| Zhu, D | 1 |
| Zhang, L | 1 |
| Liang, C | 1 |
| Mei, L | 1 |
| Huang, L | 1 |
| Zeng, X | 1 |
| Serganova, I | 1 |
| Cohen, IJ | 1 |
| Vemuri, K | 1 |
| Shindo, M | 1 |
| Maeda, M | 1 |
| Mane, M | 1 |
| Moroz, E | 1 |
| Khanin, R | 1 |
| Satagopan, J | 1 |
| Koutcher, JA | 1 |
| Blasberg, R | 1 |
| Türkcan, S | 1 |
| Kiru, L | 1 |
| Naczynski, DJ | 1 |
| Sasportas, LS | 1 |
| Pratx, G | 1 |
| Cox, BL | 1 |
| Erickson-Bhatt, S | 1 |
| Szulczewski, JM | 1 |
| Squirrell, JM | 1 |
| Ludwig, KD | 1 |
| Macdonald, EB | 1 |
| Swader, R | 1 |
| Ponik, SM | 1 |
| Eliceiri, KW | 1 |
| Fain, SB | 1 |
| Zhao, T | 1 |
| Zhu, Y | 1 |
| Morinibu, A | 1 |
| Kobayashi, M | 1 |
| Shinomiya, K | 1 |
| Itasaka, S | 1 |
| Yoshimura, M | 1 |
| Guo, G | 1 |
| Hiraoka, M | 1 |
| Harada, H | 1 |
| Sepehri, N | 1 |
| Rouhani, H | 1 |
| Tavassolian, F | 1 |
| Montazeri, H | 1 |
| Khoshayand, MR | 1 |
| Ghahremani, MH | 1 |
| Ostad, SN | 1 |
| Atyabi, F | 1 |
| Dinarvand, R | 1 |
| Shchepin, RV | 1 |
| Pham, W | 1 |
| Chekmenev, EY | 1 |
| Gross, BP | 1 |
| Wongrakpanich, A | 1 |
| Francis, MB | 1 |
| Salem, AK | 1 |
| Norian, LA | 1 |
| Iversen, AB | 1 |
| Ringgaard, S | 1 |
| Laustsen, C | 1 |
| Stødkilde-Jørgensen, H | 3 |
| Bentzen, L | 2 |
| Busk, M | 1 |
| Horsman, MR | 3 |
| Samanta, SK | 1 |
| Sehrawat, A | 1 |
| Kim, SH | 1 |
| Hahm, ER | 1 |
| Shuai, Y | 1 |
| Roy, R | 1 |
| Pore, SK | 1 |
| Singh, KB | 1 |
| Christner, SM | 1 |
| Beumer, JH | 1 |
| Davidson, NE | 1 |
| Singh, SV | 1 |
| Chen, P | 1 |
| Zuo, H | 1 |
| Xiong, H | 1 |
| Kolar, MJ | 1 |
| Chu, Q | 1 |
| Saghatelian, A | 1 |
| Siegwart, DJ | 1 |
| Wan, Y | 1 |
| Mohammadi, Z | 1 |
| Sharif Zak, M | 1 |
| Seidi, K | 1 |
| Barati, M | 1 |
| Akbarzadeh, A | 1 |
| Zarghami, N | 1 |
| Sabel, MS | 1 |
| Su, G | 1 |
| Griffith, KA | 1 |
| Chang, AE | 1 |
| Elazar, V | 1 |
| Adwan, H | 1 |
| Rohekar, K | 1 |
| Zepp, M | 1 |
| Lifshitz-Shovali, R | 1 |
| Berger, MR | 1 |
| Kersey, FR | 1 |
| Zhang, G | 1 |
| Palmer, GM | 1 |
| Dewhirst, MW | 4 |
| Fraser, CL | 1 |
| Balliet, RM | 1 |
| Capparelli, C | 1 |
| Guido, C | 1 |
| Pestell, TG | 1 |
| Martinez-Outschoorn, UE | 1 |
| Lin, Z | 1 |
| Whitaker-Menezes, D | 1 |
| Chiavarina, B | 1 |
| Pestell, RG | 1 |
| Howell, A | 1 |
| Sotgia, F | 1 |
| Lisanti, MP | 1 |
| Magnitsky, S | 1 |
| Belka, GK | 1 |
| Sterner, C | 1 |
| Pickup, S | 1 |
| Chodosh, LA | 1 |
| Glickson, JD | 2 |
| Lee, ES | 1 |
| Na, K | 1 |
| Bae, YH | 1 |
| Schroeder, T | 2 |
| Yuan, H | 1 |
| Viglianti, BL | 1 |
| Peltz, C | 2 |
| Asopa, S | 1 |
| Vujaskovic, Z | 1 |
| Rajkumar, L | 1 |
| Balasubramanian, K | 1 |
| Arunakaran, J | 1 |
| Govindarajulu, P | 1 |
| Srinivasan, N | 1 |
| Fantin, VR | 1 |
| St-Pierre, J | 1 |
| Leder, P | 1 |
| Wang, P | 1 |
| Jia, L | 1 |
| Sanders, BG | 1 |
| Kline, K | 1 |
| Shrieve, DC | 1 |
| Deen, DF | 1 |
| Harris, JW | 1 |
| Allémann, E | 2 |
| Brasseur, N | 2 |
| Benrezzak, O | 1 |
| Rousseau, J | 2 |
| Kudrevich, SV | 2 |
| Boyle, RW | 1 |
| Leroux, JC | 1 |
| Gurny, R | 1 |
| Van Lier, JE | 2 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| He, Q | 1 |
| Shungu, DC | 1 |
| van Zijl, PC | 1 |
| Bhujwalla, ZM | 1 |
| Stubbs, M | 1 |
| Rodrigues, L | 1 |
| Howe, FA | 1 |
| Jeong, KS | 1 |
| Veech, RL | 1 |
| Griffiths, JR | 1 |
| Labrie, F | 1 |
| Li, S | 1 |
| Bélanger, A | 1 |
| Côté, J | 1 |
| Mérand, Y | 1 |
| Lepage, M | 1 |
| Lewis, K | 1 |
| Nielsen, FU | 2 |
| Topp, S | 1 |
| Overgaard, J | 2 |
| Maxwell, RJ | 2 |
| Ehrhart, N | 1 |
| Dernell, WS | 2 |
| Ehrhart, EJ | 1 |
| Hutchison, JM | 1 |
| Douple, EB | 1 |
| Brekke, JH | 2 |
| Straw, RC | 1 |
| Withrow, SJ | 2 |
| Daugaard, P | 1 |
| Walenta, S | 2 |
| Snyder, S | 1 |
| Haroon, ZA | 1 |
| Braun, RD | 1 |
| Amin, K | 1 |
| Brizel, D | 1 |
| Mueller-Klieser, W | 2 |
| Chance, B | 1 |
| Morello, E | 1 |
| Kuntz, CA | 1 |
| LaRue, SM | 1 |
| Lafferty, M | 1 |
| Nelson, A | 1 |
| Mallinckrodt, CH | 1 |
| Manning, MC | 1 |
| Paschen, W | 1 |
| Kallinowski, F | 1 |
| Vaupel, P | 1 |
38 other studies available for lactic acid and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Dis | 2021 |
Polymeric nanoparticles of siRNA prepared by a double-emulsion solvent-diffusion technique: Physicochemical properties, toxicity, biodistribution and efficacy in a mammary carcinoma mice model.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Diffusion; Disease Models, Animal; Emulsi | 2017 |
A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance.
Topics: Animals; Antineoplastic Agents; Docetaxel; Dopamine; Drug Liberation; Drug Resistance, Neoplasm; Fem | 2018 |
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Hypoxia-Indu | 2018 |
Lactic Acid Accumulation in the Tumor Microenvironment Suppresses
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Fluorodeoxygl | 2019 |
A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures.
Topics: Animals; Bioreactors; Cell Line, Tumor; Cell Survival; Collagen; Contrast Media; Diffusion; Disease | 2019 |
HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs.
Topics: Anaerobiosis; Animals; Female; Glucose; Glycolysis; Hypoxia-Inducible Factor 1; Immunoenzyme Techniq | 2014 |
SN38 polymeric nanoparticles: in vitro cytotoxicity and in vivo antitumor efficacy in xenograft balb/c model with breast cancer versus irinotecan.
Topics: Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Carr | 2014 |
Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.
Topics: Animals; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Contrast Medi | 2014 |
A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer.
Topics: Animals; Antigens, Neoplasm; Autoimmunity; Biocompatible Materials; Cancer Vaccines; CD8-Positive T- | 2014 |
Hyperpolarized magnetic resonance spectroscopy for assessing tumor hypoxia.
Topics: Administration, Inhalation; Animals; Cell Hypoxia; Female; Lactic Acid; Magnetic Resonance Spectrosc | 2015 |
Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetyl Coenzyme A; Aldehyde Dehydrogenase 1 Family; Animals; Apoptosis; | 2017 |
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema | 2017 |
The Effect of Chrysin Loaded PLGA-PEG on Metalloproteinase Gene Expression in Mouse 4T1 Tumor Model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carrier | 2017 |
Intratumoral delivery of encapsulated IL-12, IL-18 and TNF-alpha in a model of metastatic breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; CD4-Positive T-Lymphocytes; CD8- | 2010 |
Biodistribution of antisense nanoparticles in mammary carcinoma rat model.
Topics: Animals; Antineoplastic Agents; Antisense Elements (Genetics); Bone Neoplasms; Carcinoma; Cell Line, | 2010 |
Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.
Topics: Absorption; Animals; Biological Transport; Boron; Coloring Agents; Lactic Acid; Mammary Neoplasms, E | 2010 |
Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Topics: Animals; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cellular Senescence; Coculture Techniques; | 2011 |
Lactate detection in inducible and orthotopic Her2/neu mammary gland tumours in mouse models.
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Lactic Acid; Mammary Neoplasms, Experimental; Mice; Re | 2013 |
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Compounding | 2005 |
Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
Topics: Animals; Blood Glucose; Cell Hypoxia; Female; Fibrosarcoma; Glucose; Lactic Acid; Liver; Mammary Neo | 2005 |
Influence of estradiol on mammary tumor collagen solubility in DMBA-induced rat mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Ascorbic Acid; Collagen; Estradiol; Female; Lactic Acid; | 2006 |
Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging.
Topics: Animals; Blood Glucose; Female; Glucose; Humans; Hyperglycemia; Lactic Acid; Liver; Luminescent Meas | 2005 |
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2006 |
Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Cell Line, Tumor; Fema | 2007 |
Effects of extreme hypoxia on the growth and viability of EMT6/SF mouse tumor cells in vitro.
Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; DNA Replication; Glucose; Hypoxia; Lactates; La | 1983 |
PEG-coated poly(lactic acid) nanoparticles for the delivery of hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumours.
Topics: Animals; Colloids; Delayed-Action Preparations; Emulsions; Glycerol; Indoles; Injections, Intravenou | 1995 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Single-scan in vivo lactate editing with complete lipid and water suppression by selective multiple-quantum-coherence transfer (Sel-MQC) with application to tumors.
Topics: Animals; Body Water; Lactates; Lactic Acid; Lipids; Magnetic Resonance Spectroscopy; Mammary Neoplas | 1995 |
Metabolic consequences of a reversed pH gradient in rat tumors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbonates; Cell Membrane Permeability; Hydr | 1994 |
Controlled release low dose medroxyprogesterone acetate (MPA) inhibits the development of mammary tumors induced by dimethyl-benz(a) anthracene in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; D | 1993 |
Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles.
Topics: Animals; Biodegradation, Environmental; Coloring Agents; Drug Carriers; Emulsions; Glycerol; Indoles | 1996 |
Localized in vivo 1H NMR spectroscopy of murine tumours: effect of blood flow reduction.
Topics: Animals; Choline; Hydralazine; Lactic Acid; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Expe | 1999 |
Effects of a controlled-release cisplatin delivery system used after resection of mammary carcinoma in mice.
Topics: Animals; Cisplatin; Combined Modality Therapy; Delayed-Action Preparations; Female; Injections, Intr | 1999 |
Effect of changing tumor oxygenation on glycolytic metabolism in a murine C3H mammary carcinoma assessed by in vivo nuclear magnetic resonance spectroscopy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Carbon Isotopes; Carbon Monoxide; Female; Glucose; Glycolysi | 2001 |
Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Diffusion Chambers, Culture; Glucose; Lactic Acid; Lu | 2001 |
Evaluation of cisplatin in combination with a biologic response modifier in a murine mammary carcinoma model.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bile; Cisplatin; Delayed-Act | 2002 |
Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting.
Topics: Adenosine Triphosphate; Animals; Colonic Neoplasms; Female; Glucose; Humans; Lactates; Lactic Acid; | 1988 |