lactic acid has been researched along with Experimental Hepatoma in 39 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Follow-up screening was performed in hepatocellular carcinoma with a focused CRISPR library targeting imaging-related genes." | 1.56 | Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer. ( Ackerman, D; Gade, TPF; Johnson, O; Mercadante, M; Perkons, NR; Pilla, G; Profka, E, 2020) |
| "Tamibarotene (Am80) has good curative effect on advanced hepatocellular carcinoma (HCC)." | 1.48 | Tamibarotene-Loaded PLGA Microspheres for Intratumoral Injection Administration: Preparation and Evaluation. ( Gao, J; Huang, G; Tian, L; Yang, Z; Zhang, Z, 2018) |
| " Unfortunately, the poor bioavailability and hydrophobicity of curcumin pose a major hurdle to its use as a potent anticancer agent." | 1.40 | Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals. ( Dua, B; Farazuddin, M; Joshi, B; Khan, AA; Owais, M; Zia, Q, 2014) |
| "To explore the efficacy of intraperitoneally injected epirubicin (EPI)-loaded poly (d, l)-lactic acid (PLA) microspheres (MS) alone or combined with free epirubicin (FEPI) in treating hepatocellular carcinoma (HCC) in mice." | 1.35 | [Efficacy of intraperitoneally injected epirubicin-loaded poly (d, l)-lactic acid microspheres alone or combined with free epirubicin in treating hepatocellular carcinoma in mice]. ( Wang, XM; Ye, SF; Zhang, QQ; Zhou, JY, 2009) |
| "To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide (Plcg) -microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy." | 1.32 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma. ( Claussen, C; Eul, T; Graepler, F; Huppert, P; Pereira, P; Qian, J; Truebenbach, J; Wiemann, G, 2003) |
| "In contrast to the hepatoma cells, rat and human hepatocytes exhibited higher rates of anaerobic glycolysis in the presence of fructose and thus were able to maintain their viability under these conditions." | 1.28 | Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. ( Anundi, I; de Groot, H; Hugo-Wissemann, D; Lauchart, W; Viebahn, R, 1991) |
| "Lactic acid was either produced or utilized, depending on the arterial whole-blood concentration." | 1.27 | Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats. ( Dauchy, RT; Sauer, LA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (17.95) | 18.7374 |
| 1990's | 11 (28.21) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 10 (25.64) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Perkons, NR | 1 |
| Johnson, O | 1 |
| Pilla, G | 1 |
| Profka, E | 1 |
| Mercadante, M | 1 |
| Ackerman, D | 1 |
| Gade, TPF | 1 |
| Tian, L | 1 |
| Gao, J | 2 |
| Yang, Z | 1 |
| Zhang, Z | 1 |
| Huang, G | 1 |
| Brinkhoff, B | 1 |
| Ostroumov, D | 1 |
| Heemcke, J | 1 |
| Woller, N | 1 |
| Gürlevik, E | 1 |
| Manns, MP | 1 |
| Longerich, T | 1 |
| Zender, L | 1 |
| Harty, JT | 1 |
| Kubicka, S | 1 |
| Kühnel, F | 1 |
| Wirth, TC | 1 |
| Farazuddin, M | 1 |
| Dua, B | 1 |
| Zia, Q | 1 |
| Khan, AA | 1 |
| Joshi, B | 1 |
| Owais, M | 1 |
| Gong, Y | 1 |
| Wang, Z | 1 |
| Dong, G | 1 |
| Sun, Y | 1 |
| Wang, X | 1 |
| Rong, Y | 1 |
| Li, M | 1 |
| Wang, D | 1 |
| Ran, H | 1 |
| Choi, JW | 1 |
| Park, JH | 1 |
| Baek, SY | 1 |
| Kim, DD | 1 |
| Kim, HC | 1 |
| Cho, HJ | 1 |
| Zhu, D | 1 |
| Tao, W | 1 |
| Zhang, H | 1 |
| Liu, G | 1 |
| Wang, T | 1 |
| Zhang, L | 1 |
| Zeng, X | 1 |
| Mei, L | 1 |
| Wilkins, LR | 1 |
| Brautigan, DL | 1 |
| Wu, H | 1 |
| Yarmohammadi, H | 1 |
| Kubicka, E | 1 |
| Serbulea, V | 1 |
| Leitinger, N | 1 |
| Liu, W | 1 |
| Haaga, JR | 1 |
| Eisenbrey, JR | 1 |
| Soulen, MC | 1 |
| Wheatley, MA | 1 |
| Zhou, JY | 2 |
| Wang, XM | 2 |
| Zhang, QQ | 2 |
| Ye, SF | 2 |
| Chen, ZK | 1 |
| Cai, MX | 1 |
| Yang, J | 1 |
| Lin, LW | 1 |
| Xue, ES | 1 |
| Huang, J | 1 |
| Wei, HF | 1 |
| Zhang, XJ | 1 |
| Ke, LM | 1 |
| Yuneva, MO | 1 |
| Fan, TW | 1 |
| Allen, TD | 1 |
| Higashi, RM | 1 |
| Ferraris, DV | 1 |
| Tsukamoto, T | 1 |
| Matés, JM | 1 |
| Alonso, FJ | 1 |
| Wang, C | 1 |
| Seo, Y | 1 |
| Chen, X | 1 |
| Bishop, JM | 1 |
| Meijsing, B | 1 |
| Carbó, N | 3 |
| López-Soriano, FJ | 3 |
| Argilés, JM | 3 |
| Qian, J | 1 |
| Truebenbach, J | 1 |
| Graepler, F | 1 |
| Pereira, P | 1 |
| Huppert, P | 1 |
| Eul, T | 1 |
| Wiemann, G | 1 |
| Claussen, C | 1 |
| Dong, AJ | 1 |
| Deng, LD | 1 |
| Sun, DX | 1 |
| Zhang, YT | 1 |
| Jin, JZ | 1 |
| Yuan, YJ | 1 |
| Liu, X | 1 |
| Heng, WS | 1 |
| Li, Q | 1 |
| Chan, LW | 1 |
| Weinberg, BD | 1 |
| Blanco, E | 1 |
| Lempka, SF | 1 |
| Anderson, JM | 1 |
| Exner, AA | 1 |
| Weng, J | 1 |
| Hou, ZQ | 1 |
| Zhou, ZM | 1 |
| Engel, F | 1 |
| Sauer, LA | 3 |
| Dauchy, RT | 3 |
| Stayman, JW | 1 |
| Ronen, SM | 1 |
| Volk, A | 1 |
| Mispelter, J | 1 |
| Javaux, F | 1 |
| Vincent, MF | 1 |
| Wagner, DR | 1 |
| van den Berghe, G | 1 |
| Anghileri, LJ | 1 |
| Maincent, P | 1 |
| Thouvenot, P | 1 |
| Cordova-Martinez, A | 1 |
| Stubbs, M | 2 |
| Rodrigues, L | 1 |
| Howe, FA | 1 |
| Wang, J | 1 |
| Jeong, KS | 1 |
| Veech, RL | 1 |
| Griffiths, JR | 2 |
| Ciftci, K | 1 |
| Hincal, AA | 1 |
| Kas, HS | 1 |
| Ercan, TM | 1 |
| Sungur, A | 1 |
| Guven, O | 1 |
| Ruacan, S | 1 |
| Robinson, SP | 1 |
| Rodrigues, LM | 1 |
| Parkins, CS | 1 |
| Collingridge, DR | 1 |
| Bastian, P | 1 |
| Bartkowski, R | 1 |
| Köhler, H | 1 |
| Kissel, T | 1 |
| Busquets, S | 1 |
| Alvarez, B | 1 |
| van Royen, M | 1 |
| Bink, H | 1 |
| Felipe, A | 1 |
| Ko, YH | 1 |
| Pedersen, PL | 1 |
| Geschwind, JF | 1 |
| Louis, NA | 1 |
| Witters, LA | 1 |
| Hugo-Wissemann, D | 1 |
| Anundi, I | 1 |
| Lauchart, W | 1 |
| Viebahn, R | 1 |
| de Groot, H | 1 |
| Mumper, RJ | 1 |
| Ryo, UY | 1 |
| Jay, M | 1 |
| Matsuno, T | 2 |
| Arora, KK | 1 |
| Smith, R | 1 |
| Williams, JF | 1 |
| Yamashita, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study[NCT02938546] | Phase 3 | 200 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
39 other studies available for lactic acid and Experimental Hepatoma
| Article | Year |
|---|---|
Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Hepatocellular; CRISPR-Cas Systems; D | 2020 |
Tamibarotene-Loaded PLGA Microspheres for Intratumoral Injection Administration: Preparation and Evaluation.
Topics: Animals; Antineoplastic Agents; Benzoates; Drug Liberation; Female; Injections, Intralesional; Lacti | 2018 |
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
Topics: Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cytokines; Flow Cytometry; I | 2014 |
Chemotherapeutic potential of curcumin-bearing microcells against hepatocellular carcinoma in model animals.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Cell Survival; Curcumin; Drug C | 2014 |
Low-intensity focused ultrasound mediated localized drug delivery for liver tumors in rabbits.
Topics: Animals; Apoptosis; Doxorubicin; Drug Delivery Systems; Lactic Acid; Liver; Liver Neoplasms; Liver N | 2016 |
Doxorubicin-loaded poly(lactic-co-glycolic acid) microspheres prepared using the solid-in-oil-in-water method for the transarterial chemoembolization of a liver tumor.
Topics: Animals; Antibiotics, Antineoplastic; Chemoembolization, Therapeutic; Doxorubicin; Drug Carriers; La | 2015 |
Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer.
Topics: Animals; Carcinoma, Hepatocellular; Docetaxel; Drug Delivery Systems; Hep G2 Cells; Humans; Indoles; | 2016 |
Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma.
Topics: Acrylates; Animals; Caffeic Acids; Cell Line, Tumor; Coumaric Acids; Disease Models, Animal; Emboliz | 2017 |
Delivery of encapsulated Doxorubicin by ultrasound-mediated size reduction of drug-loaded polymer contrast agents.
Topics: Animals; Antibiotics, Antineoplastic; Contrast Media; Doxorubicin; Drug Delivery Systems; Drug Scree | 2010 |
[Efficacy of intraperitoneally injected epirubicin-loaded poly (d, l)-lactic acid microspheres alone or combined with free epirubicin in treating hepatocellular carcinoma in mice].
Topics: Animals; Delayed-Action Preparations; Epirubicin; Infusions, Parenteral; Lactic Acid; Liver Neoplasm | 2009 |
Chemotherapy with PLGA microspheres containing docetaxel decreases angiogenesis in human hepatoma xenograft.
Topics: Angiopoietin-2; Animals; Antineoplastic Agents; Delayed-Action Preparations; Docetaxel; Drug Carrier | 2012 |
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Citric Acid Cycle; DN | 2012 |
Effects of the phosphodiesterase-IV inhibitor EMD 95832/3 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Alanine; Animals; Blood Glucose; Cachexia; Cell | 2002 |
Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Arteries; Carcinoma, Hepatocellular; Chemoembolization, Therap | 2003 |
[Studies on paclitaxel-loaded nanoparticles of amphiphilic block copolymer].
Topics: Animals; Antineoplastic Agents, Phytogenic; Delayed-Action Preparations; Drug Carriers; Drug Deliver | 2004 |
Novel polymeric microspheres containing norcantharidin for chemoembolization.
Topics: Alginates; Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma 256, W | 2006 |
Combined radiofrequency ablation and doxorubicin-eluting polymer implants for liver cancer treatment.
Topics: Absorbable Implants; Animals; Antibiotics, Antineoplastic; Catheter Ablation; Doxorubicin; Drug Deli | 2007 |
[Treatment of hepatocellular carcinoma in mice with locally administered epirubicin-loaded poly(D, L)-lactic acid microspheres].
Topics: Animals; Antibiotics, Antineoplastic; Delayed-Action Preparations; Drug Carriers; Epirubicin; Inject | 2006 |
The effect of membrane filters on cultured cells.
Topics: Animals; Cell Division; Cells, Cultured; DNA; Ethanol; Glucose; HeLa Cells; Humans; Lactates; Lactic | 1982 |
Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Amino Acids; Animals; Fasting; Female; Glucose; Glutamine; Hyd | 1983 |
Amino acid, glucose, and lactic acid utilization in vivo by rat tumors.
Topics: Amino Acids; Animals; Blood Glucose; Carcinoma 256, Walker; Female; Kinetics; Lactates; Lactic Acid; | 1982 |
Comparative NMR study of a differentiated rat hepatoma and its dedifferentiated subclone cultured as spheroids and as implanted tumors.
Topics: Alanine; Animals; Cell Differentiation; Cell Division; Energy Metabolism; Glucose; Glutamic Acid; La | 1994 |
Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells.
Topics: Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Dihydroxyacetone; Erythrocytes; Fructosephosp | 1995 |
Liver calcium homeostasis modification by iron: a probable factor in its carcinogenesis.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Radioisotopes; Cell Transformation, Neoplastic; Fe | 1994 |
Lactate release and uptake in hepatoma 7288CTC perfused in situ with L-[(U)-14C]lactate or D-[(U)-14C]glucose.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Carbon Radioisotopes; Glucose; Lactates; Lactic Acid; L | 1994 |
Metabolic consequences of a reversed pH gradient in rat tumors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbonates; Cell Membrane Permeability; Hydr | 1994 |
Solid tumor chemotherapy and in vivo distribution of fluorouracil following administration in poly(L-lactic acid) microspheres.
Topics: Animals; Antimetabolites, Antineoplastic; Biodegradation, Environmental; Chemistry, Pharmaceutical; | 1997 |
The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Glucose; Hydrogen-Ion Concentration; Lactic Aci | 1998 |
Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy.
Topics: Animals; Biocompatible Materials; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; | 1998 |
Lack of effect of the cytokine suppressive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma.
Topics: Adipose Tissue; Alanine; Animals; Anorexia; Blood Glucose; Cachexia; Cell Division; Female; Interleu | 2000 |
Hepatic transport of gluconeogenic substrates during tumor growth in the rat.
Topics: Alanine; Animals; Diffusion; Disease Progression; Female; Glucose; Glycerol; Kinetics; Lactic Acid; | 2001 |
Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cell Survival; Deoxyglucose; Drug Delivery Systems; | 2001 |
Glucose regulation of acetyl-CoA carboxylase in hepatoma and islet cells.
Topics: 3-O-Methylglucose; Acetyl-CoA Carboxylase; Alkaline Phosphatase; Animals; Bacterial Proteins; Blotti | 1992 |
Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anaerobiosis; Animals; Carci | 1991 |
Neutron-activated holmium-166-poly (L-lactic acid) microspheres: a potential agent for the internal radiation therapy of hepatic tumors.
Topics: Animals; Biodegradation, Environmental; Brachytherapy; Holmium; Lactates; Lactic Acid; Liver Neoplas | 1991 |
End products of glutamine oxidation in MC-29 virus-induced chicken hepatoma mitochondria.
Topics: Animals; Aspartate Aminotransferases; Aspartic Acid; Chickens; Citric Acid Cycle; Glutamates; Glutam | 1989 |
Oxidation of cytosolic NADH by the malate-aspartate shuttle in MC29 hepatoma cells.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Chickens; Cytosol; Glutamine; Lactates; Lactic Acid; Li | 1989 |
"Pyruvate recycling" and its influence on the estimation of the pentose pathway in intact liver and Morris hepatoma 5123TC cells.
Topics: Animals; Carbon Radioisotopes; Dicarboxylic Acids; Dihydroxyacetone Phosphate; Female; Glucose; Gluc | 1987 |
[Experimental study of an anticancer drug delivery system using polylactic acid].
Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Fluorouracil; Infusion Pumps; Lactates; | 1987 |