Page last updated: 2024-10-17

lactic acid and Erythema

lactic acid has been researched along with Erythema in 18 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

ExcerptRelevanceReference
"Although rosacea and seborrheic dermatitis share some symptoms of sensitive skin, whether they respond differently to lactic acid sting and capsaicin tests, common tests for diagnosis of sensitive skin, is unknown."8.31Rosacea and seborrheic dermatitis differentially respond to lactic acid sting and capsaicin tests in Chinese women. ( Gu, H; He, L; He, Y; Hu, M; Man, MQ; Tu, Y; Wu, P, 2023)
"To evaluate the efficiency and adverse effects of 10% all-trans retinol (ROL) gel for improvement of skin hyperpigmentation."5.10Clinical trial of bleaching treatment with 10% all-trans retinol gel. ( Aiba, E; Aoyama, T; Harii, K; Iga, T; Matsumoto, D; Mitoma, Y; Momosawa, A; Sato, K; Yoshimura, K, 2003)
"Although rosacea and seborrheic dermatitis share some symptoms of sensitive skin, whether they respond differently to lactic acid sting and capsaicin tests, common tests for diagnosis of sensitive skin, is unknown."4.31Rosacea and seborrheic dermatitis differentially respond to lactic acid sting and capsaicin tests in Chinese women. ( Gu, H; He, L; He, Y; Hu, M; Man, MQ; Tu, Y; Wu, P, 2023)
"We studied the mechanism by which fermented milk ameliorates UV-B-induced skin damage and determined the active components in milk fermented with lactic acid bacteria by evaluating erythema formation, dryness, epidermal proliferation, DNA damage and cytokine mRNA levels in hairless mice exposed to acute UV-B irradiation."3.85Exopolysaccharides Isolated from Milk Fermented with Lactic Acid Bacteria Prevent Ultraviolet-Induced Skin Damage in Hairless Mice. ( Fukasawa, T; Ichihashi, M; Kitade, M; Morifuji, M; Yamaji, T, 2017)
"For the glabellar region, severe partly vascular adverse events have been reported after treatment with injectable fillers."1.35The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study. ( Bachmann, F; Erdmann, R; Hartmann, V; Rzany, B; Wiest, L, 2009)
"Biotin deficiency associated with total parenteral nutrition is an emerging clinical problem; criteria for diagnosis and dosage for treatment are unclear."1.27Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment. ( Baker, H; Baswell, DL; Holman, RT; Mock, DM; Sweetman, L, 1985)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's6 (33.33)18.2507
2000's7 (38.89)29.6817
2010's2 (11.11)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Shu, X1
Zhao, S1
Huo, W1
Tang, Y1
Zou, L1
Li, Z1
Li, L1
Wang, X1
Hu, M1
Tu, Y1
Man, MQ1
He, Y1
Wu, P1
He, L1
Gu, H1
Morifuji, M1
Kitade, M1
Fukasawa, T1
Yamaji, T1
Ichihashi, M1
Bachmann, F1
Erdmann, R1
Hartmann, V1
Wiest, L1
Rzany, B1
Cox, SE1
Kojic, Z1
Stojanovic, D1
Popadic, S1
Jokanovic, M1
Janackovic, D1
Cho, HJ1
Chung, BY1
Lee, HB1
Kim, HO1
Park, CW1
Lee, CH1
Yoshimura, K1
Momosawa, A1
Aiba, E1
Sato, K1
Matsumoto, D1
Mitoma, Y1
Harii, K1
Aoyama, T1
Iga, T1
Basketter, DA2
Griffiths, HA1
Reed, JT1
Joseph, AK1
Bridenstine, JB1
Coverly, J1
Peters, L1
Whittle, E1
Elsner, P1
Wigger-Alberti, W1
Pantini, G1
Muizzuddin, N1
Marenus, KD1
Maes, DH1
Jennings, MB1
Logan, L1
Alfieri, DM1
Ross, CF1
Goodwin, S1
Lesczczynski, C1
Demas, PN1
Braun, TW1
Odio, M1
Streicher-Scott, J1
Hansen, RC1
Uchida, M1
Jin, Y1
Natsume, H1
Kobayashi, D1
Sugibayashi, K1
Morimoto, Y1
Mock, DM1
Baswell, DL1
Baker, H1
Holman, RT1
Sweetman, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Split-face Study of Changing in Skin Physiology and Clinical Appearance After Microdroplet Placement of Stabilized Hyaluronic Acid in Aging Faces[NCT02312154]Phase 425 participants (Actual)Interventional2014-04-30Completed
A Single Center Clinical Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris[NCT03128723]45 participants (Actual)Interventional2017-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Elasticity

"We measured a elasticity by a reviscometer device (Courage & Khazaka, Cologne, Germany).~The range of elasticity was 0 (most elastic possible as) ~400 AU(Arbitrary Unit) (inelastic as possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)242.33
Untreated Side271.15

Erythema Index

"We measured an erythema index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of erythema index is 0~999 AU(Arbitrary Unit). The range of erythema index was 0 (as non-erythematous as possible) ~999 AU (most erythematous possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)253.66
Untreated Side243.53

Global Aesthetic Improvement Scale (Investigator)

The therapeutic outcome was assessed by investigator using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse. (NCT02312154)
Timeframe: 12 weeks

Interventionscores on a scale (Mean)
Treated Side (Restylane Vital)1.38
Untreated Side0

Global Aesthetic Improvement Scale (Subject)

The therapeutic outcome was assessed by patient self-assessment using the Global Aesthetic Improvement Scale (GAIS), which rates outcome on the following 5-point scale: 3, very much improved; 2, much improved; 1, improved; 0, no change; and -1, worse (NCT02312154)
Timeframe: 12 weeks

Interventionscores on a scale (Mean)
Treated Side (Restylane Vital)1.33
Untreated Side0

Hydration Level

"We measured a hydration level by a corneometer device (Courage & Khazaka, Cologne, Germany).~The range of hydration level was 0 (as dry as possible) ~120 AU (Arbitrary Unit)(most moist possible)" (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)53.19
Untreated Side46.75

Melanin Index

"We measured a melanin index by a mexameter device (Courage & Khazaka, Cologne, Germany).~The range of melanin index was 0 (as bright as possible) ~999 AU (Arbitrary Unit) (most dark possible)." (NCT02312154)
Timeframe: 12 weeks

InterventionAU (arbitrary unit) (Mean)
Treated Side (Restylane Vital)147.25
Untreated Side149.00

Cutaneous Tolerance Scores: Burning/Stinging

Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 14. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.02

Cutaneous Tolerance Scores: Burning/Stinging

Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 28. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Dryness/Scaling

Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 14. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.11

Cutaneous Tolerance Scores: Dryness/Scaling

Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 28. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.14

Cutaneous Tolerance Scores: Edema

Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 14. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Edema

Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 28. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Erythema

Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 14. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.09

Cutaneous Tolerance Scores: Erythema

Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 28. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.07

Cutaneous Tolerance Scores: Itching

Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 14. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.04

Cutaneous Tolerance Scores: Itching

Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 28. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Tightness/Dry

Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 14. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.02

Cutaneous Tolerance Scores: Tightness/Dry Feeling

Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 28. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.05

Trials

3 trials available for lactic acid and Erythema

ArticleYear
Clinical trial of bleaching treatment with 10% all-trans retinol gel.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2003, Volume: 29, Issue:2

    Topics: Adult; Aged; Ascorbic Acid; Dermatitis, Irritant; Drug Therapy, Combination; Erythema; Female; Gels;

2003
Perfluoropolyethers in the prevention of irritant contact dermatitis.
    Dermatology (Basel, Switzerland), 1998, Volume: 197, Issue:2

    Topics: Caustics; Dermatitis, Irritant; Emulsions; Erythema; Ethers; Female; Fluorocarbons; Humans; Irritant

1998
A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.
    Journal of the American Podiatric Medical Association, 2002, Volume: 92, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Dermatologic Agents; Double-Blind Method; Erythema; Female; Foot Der

2002

Other Studies

15 other studies available for lactic acid and Erythema

ArticleYear
Clinical study of a spray containing birch juice for repairing sensitive skin.
    Archives of dermatological research, 2023, Volume: 315, Issue:8

    Topics: Betula; Erythema; Humans; Lactic Acid; Skin; Water

2023
Rosacea and seborrheic dermatitis differentially respond to lactic acid sting and capsaicin tests in Chinese women.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:12

    Topics: Capsaicin; Dermatitis, Seborrheic; East Asian People; Erythema; Female; Humans; Lactic Acid; Rosacea

2023
Exopolysaccharides Isolated from Milk Fermented with Lactic Acid Bacteria Prevent Ultraviolet-Induced Skin Damage in Hairless Mice.
    International journal of molecular sciences, 2017, Jan-13, Volume: 18, Issue:1

    Topics: Animals; Cell Proliferation; Cytokines; DNA Damage; Erythema; Female; Fermentation; Lactic Acid; Mic

2017
The spectrum of adverse reactions after treatment with injectable fillers in the glabellar region: results from the Injectable Filler Safety Study.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35 Suppl 2

    Topics: Adult; Aged; Aged, 80 and over; Biocompatible Materials; Cicatrix; Dermatologic Agents; Drug Combina

2009
Clinical experience with filler complications.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35 Suppl 2

    Topics: Acne Keloid; Adult; Aged; Anti-Bacterial Agents; Biocompatible Materials; Dermatologic Agents; Drug

2009
The irritative property of alpha-tricalcium phosphate to the rabbit skin.
    General physiology and biophysics, 2009, Volume: 28 Spec No

    Topics: Administration, Topical; Animals; Calcium Phosphates; Edema; Erythema; Female; Lactic Acid; Male; Oi

2009
Quantitative study of stratum corneum ceramides contents in patients with sensitive skin.
    The Journal of dermatology, 2012, Volume: 39, Issue:3

    Topics: Adult; Back; Ceramides; Erythema; Face; Female; Forearm; Hand; Humans; Lactic Acid; Leg; Male; Pain;

2012
A study of the relationship between susceptibility to skin stinging and skin irritation.
    Contact dermatitis, 1993, Volume: 29, Issue:4

    Topics: Erythema; Female; Humans; Irritants; Lactates; Lactic Acid; Male; Pain Threshold; Paresthesia; Patch

1993
Treatment of periorbital wrinkles. A comparison of the SilkTouch carbon dioxide laser with a medium-depth chemical peel.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1997, Volume: 23, Issue:8

    Topics: Administration, Cutaneous; Adult; Aged; Carbon Dioxide; Chemexfoliation; Cicatrix; Drug Combinations

1997
Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?
    Contact dermatitis, 1998, Volume: 38, Issue:2

    Topics: Acrolein; Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents; Antimutagenic Age

1998
Factors defining sensitive skin and its treatment.
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1998, Volume: 9, Issue:3

    Topics: Adult; Balsams; Cosmetics; Dermatitis, Contact; Dermatologic Agents; Epidermis; Erythema; Exanthema;

1998
Chemical skin resurfacing.
    Atlas of the oral and maxillofacial surgery clinics of North America, 1998, Volume: 6, Issue:2

    Topics: Anesthesia, Local; Chemexfoliation; Cicatrix; Dermatologic Agents; Dermatologic Surgical Procedures;

1998
Disposable baby wipes: efficacy and skin mildness.
    Dermatology nursing, 2001, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Clinical Trials as Topic; Diaper Rash; Erythema; Female; Household Products; Huma

2001
Introduction of poly-L-lactic acid microspheres into the skin using supersonic flow: effects of helium gas pressure, particle size and microparticle dose on the amount introduced into hairless rat skin.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biodegradation, Environmental; Drug Carriers; Eryt

2002
Biotin deficiency complicating parenteral alimentation: diagnosis, metabolic repercussions, and treatment.
    The Journal of pediatrics, 1985, Volume: 106, Issue:5

    Topics: Alopecia; Biotin; Citrates; Diagnosis, Differential; Erythema; Fatty Acids, Essential; Female; Glyci

1985