lactic acid has been researched along with Endotoxemia in 55 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability." | 7.76 | Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010) |
| "To study the effect of glutamine on intestinal barrier function by examining the changes of plasma D-lactic levels and diamine oxidase (DAO) levels in plasma and intestinal tissue after glutamine intervention in young rats with endotoxemia." | 7.76 | [Effect of oral glutamine on intestinal barrier function in young rats with endotoxemia]. ( Chang, X; Chen, P; Lian, SJ; Tang, Q; Wang, H; Wang, LL, 2010) |
| "Compared with dobutamine, levosimendan increased intestinal blood flow and diminished intramucosal acidosis in this experimental model of sepsis." | 7.74 | Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Etcheverry, G; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2007) |
| "This study demonstrates that exogenous ADM prevents and reverses hypodynamic circulation, attenuates pulmonary hypertension, and limits lactic acidosis in ovine endotoxaemia." | 7.74 | Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| "To investigate whether the vasopressin analog terlipressin might induce hepatosplanchnic ischemia during long-term, hyperdynamic, volume-resuscitated porcine endotoxemia." | 7.73 | Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Hauser, B; Iványi, Z; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005) |
| "Our data for this porcine endotoxemia model suggest that olprinone may have beneficial therapeutic effects in restoring not only systemic and hepatic circulation but also mitochondrial oxidation in the liver." | 7.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| "Dopexamine protects colonic, but not gastric mucosal epithelium in experimental endotoxin shock." | 7.72 | Dopexamine reverses colonic but not gastric mucosal perfusion defects in lethal endotoxin shock. ( Martikainen, TJ; Ruokonen, E; Tenhunen, JJ; Uusaro, A, 2003) |
| "The purpose of the study was to examine the effects of buflomedil hydrochloride (BFL) on the expression of adhesion molecules (beta2-integrins) and oxygen radical production of circulating and emigrated intra-abdominal polymorphonuclear leukocytes (PMNL) in a standardized porcine model of hyperdynamic endotoxemia." | 7.70 | Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia. ( Holzer, K; Kreimeier, U; Messmer, K; Moritz, S; Thiel, M, 1998) |
| "To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone." | 7.70 | Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000) |
| "To investigate markers of splanchnic perfusion and the extent of endotoxemia during cardiopulmonary bypass (CPB) and to compare the effects of dopamine and milrinone on both splanchnic perfusion and endotoxemia." | 5.09 | Markers of splanchnic perfusion and intestinal translocation of endotoxins during cardiopulmonary bypass: effects of dopamine and milrinone. ( Andersen, LW; Baek, L; Doolan, L; Liu, G; McNicol, L, 1999) |
| "Levosimendan did not attenuate endotoxin-induced pulmonary hypertension and did not improve myocardial function." | 3.77 | No beneficial effects of levosimendan in acute porcine endotoxaemia. ( Bendall, J; Chew, MS; Hawthorne, WJ; Huang, S; McLean, A; Simond, D; Ting, I; Whereat, S, 2011) |
| "We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability." | 3.76 | Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010) |
| "To study the effect of glutamine on intestinal barrier function by examining the changes of plasma D-lactic levels and diamine oxidase (DAO) levels in plasma and intestinal tissue after glutamine intervention in young rats with endotoxemia." | 3.76 | [Effect of oral glutamine on intestinal barrier function in young rats with endotoxemia]. ( Chang, X; Chen, P; Lian, SJ; Tang, Q; Wang, H; Wang, LL, 2010) |
| "Compared with dobutamine, levosimendan increased intestinal blood flow and diminished intramucosal acidosis in this experimental model of sepsis." | 3.74 | Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Etcheverry, G; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2007) |
| "This study demonstrates that exogenous ADM prevents and reverses hypodynamic circulation, attenuates pulmonary hypertension, and limits lactic acidosis in ovine endotoxaemia." | 3.74 | Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia. ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| "To investigate whether the vasopressin analog terlipressin might induce hepatosplanchnic ischemia during long-term, hyperdynamic, volume-resuscitated porcine endotoxemia." | 3.73 | Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Hauser, B; Iványi, Z; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005) |
| "Our data for this porcine endotoxemia model suggest that olprinone may have beneficial therapeutic effects in restoring not only systemic and hepatic circulation but also mitochondrial oxidation in the liver." | 3.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| "Levosimendan improved oxygen transport and prevented the development of intramucosal acidosis in this experimental model of endotoxaemia." | 3.73 | Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2006) |
| "Dopexamine protects colonic, but not gastric mucosal epithelium in experimental endotoxin shock." | 3.72 | Dopexamine reverses colonic but not gastric mucosal perfusion defects in lethal endotoxin shock. ( Martikainen, TJ; Ruokonen, E; Tenhunen, JJ; Uusaro, A, 2003) |
| "The purpose of the study was to examine the effects of buflomedil hydrochloride (BFL) on the expression of adhesion molecules (beta2-integrins) and oxygen radical production of circulating and emigrated intra-abdominal polymorphonuclear leukocytes (PMNL) in a standardized porcine model of hyperdynamic endotoxemia." | 3.70 | Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia. ( Holzer, K; Kreimeier, U; Messmer, K; Moritz, S; Thiel, M, 1998) |
| "To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone." | 3.70 | Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000) |
| "In rats injected with bacterial lipopolysaccharide (LPS; 5 gamma mg/g body weight [BWT]), the toxin provokes death within 24 h in 23% of the animals and, in surviving rats, causes a decrease in BWT, hyperlactacidemia, hyperlipacidemia, and hyperketonemia, as well as depletion of both liver and muscle glycogen content." | 3.69 | Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia. ( Ladriere, L; Malaisse, WJ; Nadi, AB; Zhang, TM, 1997) |
| " In addition, all tyrphostins and genistein attenuated the liver injury/failure, the pancreatic injury, the hypoglycaemia and the lactic acidosis caused by LPS." | 3.69 | Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. ( Ruetten, H; Thiemermann, C, 1997) |
| "Endotoxemia was induced by systemic injection of lipopolysaccharide (LPS) (1." | 1.62 | Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia. ( Antunes-Rodrigues, J; Batalhão, ME; Bendhack, LM; Capellari Carnio, E; de Lima Faim, F; Lacchini, R; Passaglia, P; Stabile, AM, 2021) |
| "Hypoxia and inflammation are hallmarks of critical illness, related to multiple organ failure." | 1.62 | Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males. ( Bergmans, DCJJ; Driessen, RGH; Gerretsen, J; Kiers, D; Kox, M; Pickkers, P; Schalkwijk, CG; Scheijen, JLJM; van Bussel, BCT; van de Poll, MCG; van der Horst, ICC, 2021) |
| "Endotoxemia was induced by an IV infusion of LPS for 30 minutes." | 1.56 | Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys. ( Aguilera-Aguilera, R; Buzon-Cuevas, A; Gonzalez-De Cara, C; Mendoza Garcia, FJ; Perez-Ecija, A, 2020) |
| "Twenty-nine patients with chronic hepatitis B (CHB), 28 with compensated LC, 33 with decompensated LC, 24 with spontaneous bacterial peritonitis (SBP), 26 with acute-on-chronic liver failure (ACLF), and 24 with decompensated LC complicated by hepatocellular carcinoma (HCC) were recruited." | 1.51 | Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease. ( Biviano, I; Gong, Z; Hu, J; Liu, H; Wang, A; Wang, Z, 2019) |
| "Sepsis has a well-studied inflammatory phase, with a less-understood secondary immunosuppressive phase." | 1.51 | Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability. ( Abdul Qayum, A; Abebayehu, D; Barnstein, BO; Caslin, HL; Chalfant, CE; Haque, TT; Hoeferlin, LA; Paez, PA; Pondicherry, N; Ryan, JJ; Taruselli, MT, 2019) |
| "The acute phase of sepsis is characterized by a strong inflammatory reaction." | 1.43 | Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. ( Arts, RJ; Bonten, MJ; Cheng, SC; Cremer, OL; Giamarellos-Bourboulis, EJ; Gresnigt, MS; Joosten, LA; Kox, M; Lachmandas, E; Leentjens, J; Manjeri, GR; Netea, MG; Pickkers, P; Schultz, MJ; Scicluna, BP; van de Veerdonk, FL; van der Meer, AJ; van der Poll, T; Wagenaars, JA; Willems, PH, 2016) |
| "Since the moribund hypodynamic phase of septic shock has primarily been studied in small animal models, the objective of this study was to investigate the usefulness of infusing Salmonella typhosa endotoxin at incrementing doses to establish an ovine model of hypodynamic endotoxaemia." | 1.32 | New approach to an ovine model of hypodynamic endotoxaemia. ( Bone, HG; Booke, M; Daudel, F; Sander, J; Stubbe, H; Van Aken, H; Westphal, M, 2004) |
| "The damage of gut barrier in multiple trauma appears to be more severe than that in one-site trauma, thereby promoting gut-derived endotoxemia and bacterial translocation and contributing to the development of endogenous infection." | 1.31 | Gut barrier function damage following multiple firearm injuries in a porcine model. ( Li, Z; Lu, L; Yang, X; Yao, Y; Yu, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (18.18) | 18.2507 |
| 2000's | 26 (47.27) | 29.6817 |
| 2010's | 16 (29.09) | 24.3611 |
| 2020's | 3 (5.45) | 2.80 |
| Authors | Studies |
|---|---|
| Mendoza Garcia, FJ | 1 |
| Gonzalez-De Cara, C | 1 |
| Aguilera-Aguilera, R | 1 |
| Buzon-Cuevas, A | 1 |
| Perez-Ecija, A | 1 |
| Passaglia, P | 1 |
| de Lima Faim, F | 1 |
| Batalhão, ME | 1 |
| Stabile, AM | 1 |
| Bendhack, LM | 1 |
| Antunes-Rodrigues, J | 2 |
| Lacchini, R | 1 |
| Capellari Carnio, E | 1 |
| Driessen, RGH | 1 |
| Kiers, D | 1 |
| Schalkwijk, CG | 1 |
| Scheijen, JLJM | 1 |
| Gerretsen, J | 1 |
| Pickkers, P | 2 |
| van de Poll, MCG | 1 |
| van der Horst, ICC | 1 |
| Bergmans, DCJJ | 1 |
| Kox, M | 2 |
| van Bussel, BCT | 1 |
| Crossland, H | 1 |
| Constantin-Teodosiu, D | 1 |
| Gardiner, SM | 1 |
| Greenhaff, PL | 1 |
| Wang, Z | 1 |
| Wang, A | 1 |
| Gong, Z | 1 |
| Biviano, I | 1 |
| Liu, H | 1 |
| Hu, J | 1 |
| Caslin, HL | 1 |
| Abebayehu, D | 1 |
| Abdul Qayum, A | 1 |
| Haque, TT | 1 |
| Taruselli, MT | 1 |
| Paez, PA | 1 |
| Pondicherry, N | 1 |
| Barnstein, BO | 1 |
| Hoeferlin, LA | 1 |
| Chalfant, CE | 1 |
| Ryan, JJ | 1 |
| Cheng, SC | 1 |
| Scicluna, BP | 1 |
| Arts, RJ | 1 |
| Gresnigt, MS | 1 |
| Lachmandas, E | 1 |
| Giamarellos-Bourboulis, EJ | 1 |
| Manjeri, GR | 1 |
| Wagenaars, JA | 1 |
| Cremer, OL | 1 |
| Leentjens, J | 1 |
| van der Meer, AJ | 1 |
| van de Veerdonk, FL | 1 |
| Bonten, MJ | 1 |
| Schultz, MJ | 1 |
| Willems, PH | 1 |
| Joosten, LA | 1 |
| van der Poll, T | 1 |
| Netea, MG | 1 |
| Hashiguchi, T | 2 |
| Kakihana, Y | 2 |
| Isowaki, S | 2 |
| Kuniyoshi, T | 2 |
| Kaminosono, T | 2 |
| Nagata, E | 2 |
| Tobo, K | 2 |
| Tahara, M | 2 |
| Okayama, N | 2 |
| Arakawa, Y | 1 |
| Kakihara, Y | 1 |
| Goromaru, T | 1 |
| Nakanishi, N | 1 |
| Nakazawa, H | 1 |
| Kanmura, Y | 2 |
| Nacul, FE | 1 |
| Guia, IL | 1 |
| Lessa, MA | 1 |
| Tibiriçá, E | 1 |
| Poeze, M | 1 |
| Bruins, MJ | 1 |
| Luiking, YC | 1 |
| Deutz, NE | 1 |
| Tanaka, R | 1 |
| Fujita, M | 1 |
| Tsuruta, R | 1 |
| Fujimoto, K | 1 |
| Aki, HS | 1 |
| Kumagai, K | 1 |
| Aoki, T | 1 |
| Kobayashi, A | 1 |
| Izumi, T | 1 |
| Kasaoka, S | 1 |
| Yuasa, M | 1 |
| Maekawa, T | 1 |
| Chang, X | 1 |
| Wang, LL | 1 |
| Lian, SJ | 1 |
| Tang, Q | 1 |
| Chen, P | 1 |
| Wang, H | 1 |
| Alders, DJ | 1 |
| Groeneveld, AB | 1 |
| Binsl, TW | 1 |
| de Kanter, FJ | 1 |
| van Beek, JH | 1 |
| Jesmin, S | 1 |
| Yamaguchi, N | 1 |
| Zaedi, S | 1 |
| Nusrat Sultana, S | 1 |
| Iwashima, Y | 1 |
| Sawamura, A | 1 |
| Gando, S | 1 |
| Fenhammar, J | 1 |
| Rundgren, M | 1 |
| Forestier, J | 1 |
| Kalman, S | 1 |
| Eriksson, S | 1 |
| Frithiof, R | 1 |
| Chew, MS | 2 |
| Hawthorne, WJ | 1 |
| Bendall, J | 1 |
| Whereat, S | 1 |
| Huang, S | 1 |
| Ting, I | 1 |
| Simond, D | 1 |
| McLean, A | 1 |
| Ala-Kokko, TI | 1 |
| Laurila, J | 1 |
| Koskenkari, J | 1 |
| Wellhoener, P | 1 |
| Vietheer, A | 1 |
| Sayk, F | 1 |
| Schaaf, B | 1 |
| Lehnert, H | 1 |
| Dodt, C | 1 |
| Chen, CX | 1 |
| Ouyang, B | 1 |
| Lai, JB | 1 |
| Qiu, CF | 1 |
| Guan, XD | 1 |
| Saia, RS | 1 |
| Bertozi, G | 1 |
| Mestriner, FL | 1 |
| Queiróz Cunha, F | 1 |
| Cárnio, EC | 1 |
| Bundgaard, H | 1 |
| Kjeldsen, K | 1 |
| Suarez Krabbe, K | 1 |
| van Hall, G | 1 |
| Simonsen, L | 1 |
| Qvist, J | 1 |
| Hansen, CM | 1 |
| Moller, K | 1 |
| Fonsmark, L | 1 |
| Lav Madsen, P | 1 |
| Klarlund Pedersen, B | 1 |
| Levy, B | 1 |
| Mansart, A | 1 |
| Bollaert, PE | 1 |
| Franck, P | 1 |
| Mallie, JP | 1 |
| Heller, AR | 1 |
| Heller, SC | 1 |
| Borkenstein, A | 1 |
| Stehr, SN | 1 |
| Koch, T | 1 |
| Li, Z | 1 |
| Yang, X | 1 |
| Lu, L | 1 |
| Yu, Y | 1 |
| Yao, Y | 1 |
| Tenhunen, JJ | 1 |
| Martikainen, TJ | 1 |
| Uusaro, A | 1 |
| Ruokonen, E | 1 |
| Bäckström, T | 1 |
| Liska, J | 1 |
| Oldner, A | 1 |
| Lockowandt, U | 1 |
| Franco-Cereceda, A | 1 |
| Westphal, M | 2 |
| Daudel, F | 1 |
| Bone, HG | 1 |
| Van Aken, H | 2 |
| Sander, J | 1 |
| Stubbe, H | 1 |
| Booke, M | 2 |
| Asfar, P | 1 |
| Hauser, B | 1 |
| Iványi, Z | 1 |
| Ehrmann, U | 1 |
| Kick, J | 1 |
| Albicini, M | 1 |
| Vogt, J | 2 |
| Wachter, U | 2 |
| Brückner, UB | 1 |
| Radermacher, P | 4 |
| Bracht, H | 2 |
| Venkatesh, B | 1 |
| Morgan, TJ | 1 |
| Hall, J | 1 |
| Endre, Z | 1 |
| Willgoss, D | 1 |
| Porta, F | 1 |
| Takala, J | 1 |
| Kolarova, A | 1 |
| Ma, Y | 1 |
| Redaelli, CA | 1 |
| Brander, L | 1 |
| Jakob, SM | 1 |
| Jeschke, MG | 1 |
| Rensing, H | 1 |
| Klein, D | 1 |
| Schubert, T | 1 |
| Mautes, AE | 1 |
| Bolder, U | 1 |
| Croner, RS | 1 |
| Kawamae, H | 1 |
| Dubin, A | 2 |
| Maskin, B | 2 |
| Murias, G | 2 |
| Pozo, MO | 2 |
| Sottile, JP | 2 |
| Barán, M | 2 |
| Edul, VS | 2 |
| Canales, HS | 2 |
| Estenssoro, E | 2 |
| Etcheverry, G | 1 |
| Carbonell, LF | 1 |
| Díaz, J | 1 |
| Hernández, I | 1 |
| Cuevas, S | 1 |
| Valero, F | 1 |
| Quesada, T | 1 |
| Fenoy, F | 1 |
| Salom, MG | 1 |
| Jørgensen, VL | 1 |
| Ibsen, M | 1 |
| Andresen, L | 1 |
| Schulzke, JD | 1 |
| Perner, A | 1 |
| Ertmer, C | 1 |
| Morelli, A | 1 |
| Rehberg, S | 1 |
| Lange, M | 1 |
| Hucklenbruch, C | 1 |
| Johansson, A | 1 |
| Anderson, C | 1 |
| Ersson, A | 1 |
| Tønnesen, E | 1 |
| Malaisse, WJ | 1 |
| Nadi, AB | 1 |
| Ladriere, L | 1 |
| Zhang, TM | 1 |
| Leclercq, P | 1 |
| Filippi, C | 1 |
| Sibille, B | 1 |
| Hamant, S | 1 |
| Keriel, C | 1 |
| Leverve, XM | 1 |
| Kellum, JA | 2 |
| Bellomo, R | 1 |
| Kramer, DJ | 1 |
| Pinsky, MR | 2 |
| Ruetten, H | 1 |
| Thiemermann, C | 2 |
| Ravindranath, T | 1 |
| Topaloglu, AK | 1 |
| Goto, M | 1 |
| Zeller, WP | 1 |
| Wray, GM | 1 |
| Hinds, CJ | 1 |
| Holzer, K | 1 |
| Thiel, M | 1 |
| Kreimeier, U | 1 |
| Moritz, S | 1 |
| Messmer, K | 1 |
| McNicol, L | 1 |
| Andersen, LW | 1 |
| Liu, G | 1 |
| Doolan, L | 1 |
| Baek, L | 1 |
| Olszanecki, R | 1 |
| Chłopicki, S | 1 |
| Wagner, K | 1 |
| Schäfer, R | 1 |
| Roth-Isigkeit, A | 1 |
| Klotz, KF | 1 |
| Friedrich, HJ | 1 |
| Schmucker, P | 1 |
| Rico, P | 1 |
| Garuba, AK | 1 |
| Agwunobi, AO | 1 |
| Reid, C | 1 |
| Maycock, P | 1 |
| Little, RA | 1 |
| Carlson, GL | 1 |
| Träger, K | 3 |
| Matejovic, M | 3 |
| Zülke, C | 1 |
| Vlatten, A | 1 |
| Altherr, J | 1 |
| Brinkmann, A | 1 |
| Jauch, KW | 1 |
| Georgieff, M | 3 |
| Möller, AD | 1 |
| Grände, PO | 1 |
| Theisen, M | 2 |
| Tugtekin, I | 1 |
| Stehr, A | 2 |
| Ploner, F | 2 |
| Tugtekin, IF | 1 |
| Matura, K | 1 |
| Ince, C | 1 |
| Li, JY | 1 |
| Lu, Y | 1 |
| Hu, S | 1 |
| Sun, D | 1 |
| Yao, YM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparing Cytokines, Toxins Adsorbing oXiris Filter to ST150 Filter During CRRT in Patients With Septic Shock[NCT02600312] | 16 participants (Actual) | Interventional | 2015-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for lactic acid and Endotoxemia
| Article | Year |
|---|---|
Metabolic alterations in adipose tissue during the early phase of experimental endotoxemia in humans.
Topics: Adult; Biomarkers; Double-Blind Method; Endotoxemia; Glycerol; Glycolysis; Humans; Injections, Intra | 2011 |
Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans.
Topics: Adult; Aerobiosis; Arm; Arteries; Endotoxemia; Endotoxins; Epinephrine; Fever; Humans; Hypokalemia; | 2003 |
Markers of splanchnic perfusion and intestinal translocation of endotoxins during cardiopulmonary bypass: effects of dopamine and milrinone.
Topics: Adult; Aged; Biological Transport; Cardiopulmonary Bypass; Dopamine; Endotoxemia; Endotoxins; Humans | 1999 |
Insulin resistance and substrate utilization in human endotoxemia.
Topics: Adult; Blood Glucose; Body Temperature; Calorimetry, Indirect; Endotoxemia; Female; Glucose Clamp Te | 2000 |
51 other studies available for lactic acid and Endotoxemia
| Article | Year |
|---|---|
Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Endotoxemia; Equidae; Female; Int | 2020 |
Central Administration of Angiotensin-(1-7) Improves Vasopressin Impairment and Hypotensive Response in Experimental Endotoxemia.
Topics: Angiotensin I; Animals; Endotoxemia; Gene Expression Regulation; Hypotension; Inflammation; Lactic A | 2021 |
Systemic inflammation down-regulates glyoxalase-1 expression: an experimental study in healthy males.
Topics: Adolescent; Adult; Biomarkers; Down-Regulation; Endotoxemia; Healthy Volunteers; Humans; Hypoxia; In | 2021 |
Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.
Topics: Animals; Drug Evaluation, Preclinical; Endotoxemia; Gene Expression Regulation; Interleukin-6; Lacti | 2017 |
Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease.
Topics: Acute-On-Chronic Liver Failure; Adult; Aged; Analysis of Variance; Biomarkers; Carcinoma, Hepatocell | 2019 |
Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability.
Topics: Adenosine Triphosphate; Animals; Cytokines; Endotoxemia; Glycolysis; Inflammation; Lactic Acid; Lipo | 2019 |
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis.
Topics: Adenosine Triphosphate; Adult; Animals; Antifungal Agents; Aspergillosis; Candidiasis, Invasive; Cyt | 2016 |
Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia.
Topics: Animals; Arachidonic Acids; Biopterins; Disease Models, Animal; Endocannabinoids; Endotoxemia; Hemod | 2008 |
The effects of vasoactive drugs on intestinal functional capillary density in endotoxemic rats: intravital video-microscopy analysis.
Topics: Animals; Capillaries; Cardiotonic Agents; Dobutamine; Dopamine; Endotoxemia; Epinephrine; Escherichi | 2010 |
Reduced caloric intake during endotoxemia reduces arginine availability and metabolism.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Endotoxins; Energy Intake; Escherichia coli; | 2010 |
Urinary trypsin inhibitor suppresses excessive generation of superoxide anion radical, systemic inflammation, oxidative stress, and endothelial injury in endotoxemic rats.
Topics: Animals; Endothelium; Endotoxemia; Glycoproteins; HMGB1 Protein; Humans; Inflammation; Intercellular | 2010 |
[Effect of oral glutamine on intestinal barrier function in young rats with endotoxemia].
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Behavior, Animal; Endotoxemia; Fem | 2010 |
Endotoxemia decreases matching of regional blood flow and O2 delivery to O2 uptake in the porcine left ventricle.
Topics: Animals; Cardiac Output; Coronary Circulation; Coronary Vessels; Endotoxemia; Endotoxins; Hypotensio | 2011 |
Time-dependent expression of endothelin-1 in lungs and the effects of TNF-α blocking peptide on acute lung injury in an endotoxemic rat model.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Blood Pressure; Endothelin-1; Endotoxemia; Lactic Ac | 2011 |
Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cardiac Output; Creatinine; Disease Models, Anima | 2011 |
No beneficial effects of levosimendan in acute porcine endotoxaemia.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Cytokines; Echocardiography; Endotoxemia; Heart Functio | 2011 |
A new endotoxin adsorber in septic shock: observational case series.
Topics: Adsorption; Aged; Aged, 80 and over; Case-Control Studies; Endotoxemia; Endotoxins; Female; Hemoperf | 2011 |
[The protective effects of inhibition of c-Jun N-terminal kinase signal pathway on the intestinal barrier in rats with endotoxemia].
Topics: Animals; Anthracenes; Endotoxemia; Intestinal Mucosa; Intestines; JNK Mitogen-Activated Protein Kina | 2012 |
Cardiovascular and inflammatory response to cholecystokinin during endotoxemic shock.
Topics: Animals; Aorta; Blood Pressure; Cholecystokinin; Drug Evaluation, Preclinical; Endotoxemia; Heart Ra | 2013 |
Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats.
Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Gas Analysis; Diseas | 2003 |
Modulation of host defense by hydrocortisone in stress doses during endotoxemia.
Topics: Animals; Biomarkers; Blood Pressure; Colony Count, Microbial; Dose-Response Relationship, Drug; Endo | 2003 |
Gut barrier function damage following multiple firearm injuries in a porcine model.
Topics: Amine Oxidase (Copper-Containing); Animals; Bacterial Translocation; Endotoxemia; Endotoxins; Femora | 2001 |
Dopexamine reverses colonic but not gastric mucosal perfusion defects in lethal endotoxin shock.
Topics: Animals; Anti-Inflammatory Agents; Carbon Dioxide; Cardiac Output; Colon; Dopamine; Endotoxemia; End | 2003 |
Splanchnic metabolism during gut ischemia and short-term endotoxin and hemorrhagic shock as evaluated by intravasal microdialysis.
Topics: Abdomen; Animals; Endotoxemia; Endotoxins; Glucose; Glycerol; Hemodynamics; Ileum; Ischemia; Lactic | 2004 |
New approach to an ovine model of hypodynamic endotoxaemia.
Topics: Animals; Bacterial Toxins; Body Temperature; Carbon Dioxide; Cardiac Output; Disease Models, Animal; | 2004 |
Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism.
Topics: Animals; Blood Pressure; Cardiac Output; Endotoxemia; Endotoxins; Escherichia coli; Female; Glucose; | 2005 |
Subcutaneous gas tensions closely track ileal mucosal gas tensions in a model of endotoxaemia without anaerobism.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Il | 2005 |
Oxygen extraction in pigs subjected to low-dose infusion of endotoxin after major abdominal surgery.
Topics: Abdomen; Animals; Blood Gas Analysis; Blood Pressure; Endotoxemia; Endotoxins; Heart Atria; Hemodyna | 2005 |
Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats.
Topics: Acute-Phase Proteins; Adenosine Triphosphate; Animals; Apoptosis; Blood Glucose; Caspase 3; Caspase | 2005 |
Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Electron Transport Complex IV; Endotoxemia; Endotoxins; Hemoglobins | 2005 |
Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study.
Topics: Acidosis; Animals; Disease Models, Animal; Endotoxemia; Escherichia coli Infections; Hemodynamics; H | 2006 |
Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study.
Topics: Acidosis; Analysis of Variance; Animals; Cardiotonic Agents; Dobutamine; Endotoxemia; Hydrazones; La | 2007 |
N-acetylcysteine exerts protective effects and prevents lung redox imbalance and peroxynitrite generation in endotoxemic rats.
Topics: Acetylcysteine; Animals; Coloring Agents; Endotoxemia; Enzyme Inhibitors; Free Radical Scavengers; L | 2007 |
Effects of endotoxaemia on markers of permeability, metabolism and inflammation in the large bowel of healthy subjects.
Topics: Adult; Apoptosis; Biomarkers; Cross-Over Studies; Endotoxemia; Endotoxins; Humans; Inflammation; Int | 2007 |
Exogenous adrenomedullin prevents and reverses hypodynamic circulation and pulmonary hypertension in ovine endotoxaemia.
Topics: Acidosis, Lactic; Adrenomedullin; Animals; Cardiac Output; Drug Evaluation, Preclinical; Endotoxemia | 2007 |
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Endotoxemia; Glucose; Lactic Acid; M | 2008 |
Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia.
Topics: Adenine Nucleotides; Animals; Blood Glucose; Body Weight; Endotoxemia; Female; Glucose; Glycogen; In | 1997 |
Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats.
Topics: Adenine Nucleotides; Animals; Caprylates; Cell Membrane Permeability; Cells, Cultured; Dihydroxyacet | 1997 |
Fixed acid uptake by visceral organs during early endotoxemia.
Topics: Acidosis; Acidosis, Lactic; Acids; Animals; Bicarbonates; Biological Transport, Active; Body Fluids; | 1997 |
Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase.
Topics: Acidosis, Lactic; Animals; Cells, Cultured; Cyclooxygenase 2; Endotoxemia; Endotoxins; Enzyme Induct | 1997 |
Effects of hydrazine sulfate on galactosamine-sensitized endotoxic shock in ten-day-old rats.
Topics: Animals; Blood Glucose; Endotoxemia; Female; Galactosamine; Hydrazines; Lactic Acid; Rats; Rats, Spr | 1998 |
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidne | 1998 |
Buflomedil hydrochloride reduces systemic activation of polymorphonuclear leukocytes during hyperdynamic endotoxemia.
Topics: Animals; CD18 Antigens; Cell Adhesion Molecules; Endotoxemia; Endotoxins; Gastric Mucosa; Hemodynami | 1998 |
Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia.
Topics: Animals; Azepines; Cell Movement; Endotoxemia; Indans; Lactic Acid; Lipopolysaccharides; Lung; Male; | 1999 |
Norepinephrine vs nitric oxide synthase inhibition in endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Female; Hepatic Artery; Lactic Acid | 1999 |
Accuracy of mucosal pH and mucosal-arterial carbon dioxide tension for detecting mesenteric hypoperfusion in acute canine endotoxemia.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Disease Models, Animal; Dogs; Endotoxemia; Escherichia | 2000 |
Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Ener | 2000 |
Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables.
Topics: Animals; Antihypertensive Agents; Blood Gas Analysis; Cats; Constriction, Pathologic; Disease Models | 2001 |
Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Disease Models, Animal; Drug Evaluation | 2001 |
Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Escherichia coli I | 2001 |
Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma.
Topics: Amine Oxidase (Copper-Containing); Animals; Endotoxemia; Endotoxins; Glutamine; Intestinal Absorptio | 2002 |