Page last updated: 2024-10-17

lactic acid and Encephalopathy, Traumatic

lactic acid has been researched along with Encephalopathy, Traumatic in 32 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"A prehospital trauma triage algorithm must reliably identify a patient bleeding or suffering from significant brain injuries."3.01The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature. ( Ahnert, T; Bieler, D; Imach, S; Neubert, A; Stojek, L, 2023)
"SL is an effective therapy for treating brain edema after TBI."1.62The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach. ( Duhaut, DE; Gandin, C; Heurteaux, C; Ichai, C; Quintard, H, 2021)
"Arterial hyperglycemia is associated with poor outcome in traumatic brain injury (TBI), but the pathophysiology is not completely understood."1.51High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury. ( Enblad, P; Hillered, L; Howells, T; Lewén, A; Ronne-Engström, E; Rostami, E; Svedung Wettervik, T, 2019)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (43.75)24.3611
2020's18 (56.25)2.80

Authors

AuthorsStudies
Guilfoyle, MR1
Helmy, A2
Donnelly, J1
Stovell, MG1
Timofeev, I1
Pickard, JD1
Czosnyka, M2
Smielewski, P1
Menon, DK2
Carpenter, KLH1
Hutchinson, PJ1
van Gemert, LA1
de Galan, BE1
Wevers, RA1
Ter Heine, R1
Willemsen, MA1
D'Souza, P1
Hayworth, M1
Oliver, B1
Gopinath, SP1
Karas, PJ1
Li, Z1
Xu, C1
Wang, Y2
Lei, X1
Qin, D1
Zhu, G1
Wang, YM3
Zhu, N3
Zhou, YM3
Su, R3
Li, HL3
Zhou, JX3
Stojek, L1
Bieler, D1
Neubert, A1
Ahnert, T1
Imach, S1
Lee, JH1
Lee, D1
Lee, BK1
Cho, YS1
Kim, DK1
Jung, YH1
Ryu, SJ1
No, E1
Banoei, MM1
Lee, CH1
Hutchison, J1
Panenka, W1
Wellington, C1
Wishart, DS1
Winston, BW1
Greco, T1
Vespa, PM3
Prins, ML1
Zhai, X1
Li, J1
Li, L1
Sun, Y1
Zhang, X1
Xue, Y1
Lv, J1
Gao, Y1
Li, S1
Yan, W1
Yin, S1
Xiao, Z1
Lekomtseva, Y1
Svedung Wettervik, T2
Engquist, H1
Howells, T2
Rostami, E2
Hillered, L2
Enblad, P2
Lewén, A2
Crespy, T1
Durost, M1
Fricault, P1
Lemasson, B1
Bouzat, P3
Barbier, EL1
Payen, JF1
Tang, W1
Fang, F1
Liu, K1
Huang, Z1
Li, H1
Yin, Y1
Wang, J1
Wang, G1
Wei, L1
Ou, Y1
Duhaut, DE1
Heurteaux, C1
Gandin, C1
Ichai, C1
Quintard, H3
Annoni, F1
Peluso, L1
Gouvêa Bogossian, E1
Creteur, J2
Zanier, ER1
Taccone, FS2
Wolahan, SM1
Mao, HC1
Real, C1
Glenn, TC2
Mannino, C1
Hovda, DA1
McArthur, DL1
Van Horn, JD1
Wright, MJ1
Gupta, D1
Singla, R1
Mazzeo, AT1
Schnieder, EB1
Tandon, V1
Kale, SS1
Mahapatra, AK1
Zeiler, FA1
Thelin, EP1
Hutchinson, PJA1
Carteron, L1
Solari, D1
Patet, C2
Miroz, JP1
Bloch, J2
Daniel, RT1
Hirt, L1
Eckert, P1
Magistretti, PJ3
Oddo, M4
Zhou, T1
Kalanuria, A1
Lozano, A1
Franchi, F1
Seastres, RJ1
Lheureux, O1
Badenes, R1
Scolletta, S1
Vincent, JL1
Ronne-Engström, E1
Sala, N1
Suys, T2
Zerlauth, JB2
Marques-Vidal, P1
Feihl, F1
Messerer, M1
Levivier, M1
Meuli, R2
Pellerin, L1
Nordström, CH2
Nielsen, TH1
Schalén, W1
Reinstrup, P1
Ungerstedt, U1
Khalin, I1
Alyautdin, R1
Wong, TW1
Gnanou, J1
Kocherga, G1
Kreuter, J1
Balança, B1
Meiller, A1
Bezin, L1
Dreier, JP1
Marinesco, S1
Lieutaud, T1
Dienel, GA1
Rothman, DL1
Dekker, SE1
de Vries, HM1
Lubbers, WD1
van de Ven, PM1
Toor, EJ1
Bloemers, FW1
Geeraedts, LMG1
Schober, P1
Boer, C1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury[NCT01573507]42 participants (Actual)Interventional2012-03-31Completed
Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488]Phase 20 participants (Actual)Interventional2020-09-30Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication)
Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549]100 participants (Anticipated)Observational2017-09-16Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for lactic acid and Encephalopathy, Traumatic

ArticleYear
Lactate infusion as therapeutical intervention: a scoping review.
    European journal of pediatrics, 2022, Volume: 181, Issue:6

    Topics: Adult; Brain Injuries, Traumatic; Child; Humans; Hypoglycemia; Lactic Acid; Sodium Lactate; Waste Pr

2022
The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature.
    European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023, Volume: 49, Issue:4

    Topics: Brain Injuries, Traumatic; Emergency Medical Services; Humans; Lactic Acid; Point-of-Care Systems; P

2023
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?
    Cells, 2021, 07-06, Volume: 10, Issue:7

    Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo

2021
A systematic review of cerebral microdialysis and outcomes in TBI: relationships to patient functional outcome, neurophysiologic measures, and tissue outcome.
    Acta neurochirurgica, 2017, Volume: 159, Issue:12

    Topics: Brain Chemistry; Brain Injuries, Traumatic; Glasgow Outcome Scale; Glucose; Glutamic Acid; Humans; L

2017
Cerebral Microdialysis in Neurocritical Care.
    Current neurology and neuroscience reports, 2018, 10-23, Volume: 18, Issue:12

    Topics: Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Glucose; Humans; Lactic Acid; Microdialysis;

2018

Trials

2 trials available for lactic acid and Encephalopathy, Traumatic

ArticleYear
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
    Intensive care medicine, 2014, Volume: 40, Issue:3

    Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I

2014
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
    Intensive care medicine, 2014, Volume: 40, Issue:3

    Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I

2014
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
    Intensive care medicine, 2014, Volume: 40, Issue:3

    Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I

2014
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
    Intensive care medicine, 2014, Volume: 40, Issue:3

    Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I

2014
Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio.
    Journal of neurotrauma, 2016, Apr-01, Volume: 33, Issue:7

    Topics: Adult; Blood Glucose; Brain Injuries, Traumatic; Energy Metabolism; Female; Humans; Imaging, Three-D

2016

Other Studies

25 other studies available for lactic acid and Encephalopathy, Traumatic

ArticleYear
Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients.
    PloS one, 2021, Volume: 16, Issue:12

    Topics: Adult; Arterial Pressure; Brain; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Glucose; Hum

2021
Commentary: Lactate, the Astrocyte-Neuron Lactate Shuttle, and Neuroprotection in Traumatic Brain Injury.
    Neurosurgery, 2022, 06-01, Volume: 90, Issue:6

    Topics: Astrocytes; Brain; Brain Injuries, Traumatic; Humans; Lactic Acid; Neurons; Neuroprotection

2022
Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level.
    Journal of biomedical nanotechnology, 2022, Mar-01, Volume: 18, Issue:3

    Topics: Animals; Brain Injuries, Traumatic; Chalcones; Cyclooxygenase 2; Humans; Lactic Acid; Polyethylene G

2022
To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury.
    BioMed research international, 2022, Volume: 2022

    Topics: Brain Injuries; Brain Injuries, Traumatic; Choline; Coma; Creatinine; Diffusion Tensor Imaging; Huma

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
    BMC neurology, 2022, Nov-15, Volume: 22, Issue:1

    Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies

2022
The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2023, Volume: 29, Issue:7

    Topics: Abbreviated Injury Scale; Blood Transfusion; Brain Injuries, Traumatic; Humans; Lactic Acid; Retrosp

2023
Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.
    Critical care (London, England), 2023, 07-22, Volume: 27, Issue:1

    Topics: Brain Injuries, Traumatic; Canada; Chromatography, Liquid; Glasgow Outcome Scale; Humans; Lactic Aci

2023
Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.
    Experimental neurology, 2020, Volume: 329

    Topics: 3-Hydroxybutyric Acid; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Energy Metabolism; Femal

2020
L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model.
    Brain research, 2020, 11-01, Volume: 1746

    Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Lactic Acid; Male; Neuronal Plast

2020
Targeting higher levels of lactate in the post-injury period following traumatic brain injury.
    Clinical neurology and neurosurgery, 2020, Volume: 196

    Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Female; Humans; Lactic Acid; Male; Middle Aged; Pyruvi

2020
Arterial lactate in traumatic brain injury - Relation to intracranial pressure dynamics, cerebral energy metabolism and clinical outcome.
    Journal of critical care, 2020, Volume: 60

    Topics: Adult; Age Factors; Arteries; Biomarkers; Brain Injuries, Traumatic; Cerebrovascular Circulation; En

2020
Hypertonic Sodium Lactate to Alleviate Functional Deficits Following Diffuse Traumatic Brain Injury: An Osmotic or a Lactate-Related Effect?
    Neurocritical care, 2021, Volume: 34, Issue:3

    Topics: Animals; Brain Injuries, Traumatic; Hypertonic Solutions; Lactic Acid; Rats; Saline Solution, Hypert

2021
Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair.
    ACS biomaterials science & engineering, 2020, 04-13, Volume: 6, Issue:4

    Topics: Animals; Brain Injuries, Traumatic; Lactic Acid; Neurites; Neuronal Outgrowth; Rats; Tissue Scaffold

2020
The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.
    Neurocritical care, 2021, Volume: 35, Issue:3

    Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Intracranial Hypertension; Intracranial Pressure; L

2021
Lactate supplementation in severe traumatic brain injured adults by primed constant infusion of sodium L-lactate.
    Journal of neuroscience research, 2018, Volume: 96, Issue:4

    Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Humans; Inf

2018
Acute glucose and lactate metabolism are associated with cognitive recovery following traumatic brain injury.
    Journal of neuroscience research, 2018, Volume: 96, Issue:4

    Topics: Adult; Brain Injuries, Traumatic; Cognition; Energy Metabolism; Frontal Lobe; Glasgow Coma Scale; Gl

2018
Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: A microdialysis study.
    Brain injury, 2017, Volume: 31, Issue:12

    Topics: Brain Injuries, Traumatic; Cerebrovascular Circulation; Decompressive Craniectomy; Female; Glasgow O

2017
Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury.
    Critical care medicine, 2018, Volume: 46, Issue:10

    Topics: Adult; Blood Glucose; Brain Injuries, Traumatic; Female; Frontal Lobe; Glasgow Coma Scale; Humans; I

2018
Glucose and Lactate Concentrations in Cerebrospinal Fluid After Traumatic Brain Injury.
    Journal of neurosurgical anesthesiology, 2020, Volume: 32, Issue:2

    Topics: Adult; Aged; Brain; Brain Injuries, Traumatic; Female; Glucose; Humans; Lactic Acid; Male; Middle Ag

2020
High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury.
    Neurocritical care, 2019, Volume: 31, Issue:3

    Topics: Adult; Arterial Pressure; Blood Glucose; Blood Pressure; Brain; Brain Injuries, Traumatic; Cerebrova

2019
Biochemical indications of cerebral ischaemia and mitochondrial dysfunction in severe brain trauma analysed with regard to type of lesion.
    Acta neurochirurgica, 2016, Volume: 158, Issue:7

    Topics: Adult; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Infarction; Energy Metabolism; Female; Gl

2016
Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury.
    Drug delivery, 2016, Volume: 23, Issue:9

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Brain-Derived Neurotrophic Factor; C

2016
Altered hypermetabolic response to cortical spreading depolarizations after traumatic brain injury in rats.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:5

    Topics: Animals; Brain; Brain Injuries, Traumatic; Cerebrovascular Circulation; Cortical Spreading Depressio

2017
Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016, Volume: 36, Issue:11

    Topics: Brain; Brain Injuries, Traumatic; Critical Care; Energy Metabolism; Glucose; Humans; Lactic Acid; Mi

2016
Lactate clearance metrics are not superior to initial lactate in predicting mortality in trauma.
    European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2017, Volume: 43, Issue:6

    Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Humans; Lactic Acid; Male;

2017