lactic acid has been researched along with Encephalopathy, Traumatic in 32 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prehospital trauma triage algorithm must reliably identify a patient bleeding or suffering from significant brain injuries." | 3.01 | The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature. ( Ahnert, T; Bieler, D; Imach, S; Neubert, A; Stojek, L, 2023) |
| "SL is an effective therapy for treating brain edema after TBI." | 1.62 | The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach. ( Duhaut, DE; Gandin, C; Heurteaux, C; Ichai, C; Quintard, H, 2021) |
| "Arterial hyperglycemia is associated with poor outcome in traumatic brain injury (TBI), but the pathophysiology is not completely understood." | 1.51 | High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury. ( Enblad, P; Hillered, L; Howells, T; Lewén, A; Ronne-Engström, E; Rostami, E; Svedung Wettervik, T, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 18 (56.25) | 2.80 |
| Authors | Studies |
|---|---|
| Guilfoyle, MR | 1 |
| Helmy, A | 2 |
| Donnelly, J | 1 |
| Stovell, MG | 1 |
| Timofeev, I | 1 |
| Pickard, JD | 1 |
| Czosnyka, M | 2 |
| Smielewski, P | 1 |
| Menon, DK | 2 |
| Carpenter, KLH | 1 |
| Hutchinson, PJ | 1 |
| van Gemert, LA | 1 |
| de Galan, BE | 1 |
| Wevers, RA | 1 |
| Ter Heine, R | 1 |
| Willemsen, MA | 1 |
| D'Souza, P | 1 |
| Hayworth, M | 1 |
| Oliver, B | 1 |
| Gopinath, SP | 1 |
| Karas, PJ | 1 |
| Li, Z | 1 |
| Xu, C | 1 |
| Wang, Y | 2 |
| Lei, X | 1 |
| Qin, D | 1 |
| Zhu, G | 1 |
| Wang, YM | 3 |
| Zhu, N | 3 |
| Zhou, YM | 3 |
| Su, R | 3 |
| Li, HL | 3 |
| Zhou, JX | 3 |
| Stojek, L | 1 |
| Bieler, D | 1 |
| Neubert, A | 1 |
| Ahnert, T | 1 |
| Imach, S | 1 |
| Lee, JH | 1 |
| Lee, D | 1 |
| Lee, BK | 1 |
| Cho, YS | 1 |
| Kim, DK | 1 |
| Jung, YH | 1 |
| Ryu, SJ | 1 |
| No, E | 1 |
| Banoei, MM | 1 |
| Lee, CH | 1 |
| Hutchison, J | 1 |
| Panenka, W | 1 |
| Wellington, C | 1 |
| Wishart, DS | 1 |
| Winston, BW | 1 |
| Greco, T | 1 |
| Vespa, PM | 3 |
| Prins, ML | 1 |
| Zhai, X | 1 |
| Li, J | 1 |
| Li, L | 1 |
| Sun, Y | 1 |
| Zhang, X | 1 |
| Xue, Y | 1 |
| Lv, J | 1 |
| Gao, Y | 1 |
| Li, S | 1 |
| Yan, W | 1 |
| Yin, S | 1 |
| Xiao, Z | 1 |
| Lekomtseva, Y | 1 |
| Svedung Wettervik, T | 2 |
| Engquist, H | 1 |
| Howells, T | 2 |
| Rostami, E | 2 |
| Hillered, L | 2 |
| Enblad, P | 2 |
| Lewén, A | 2 |
| Crespy, T | 1 |
| Durost, M | 1 |
| Fricault, P | 1 |
| Lemasson, B | 1 |
| Bouzat, P | 3 |
| Barbier, EL | 1 |
| Payen, JF | 1 |
| Tang, W | 1 |
| Fang, F | 1 |
| Liu, K | 1 |
| Huang, Z | 1 |
| Li, H | 1 |
| Yin, Y | 1 |
| Wang, J | 1 |
| Wang, G | 1 |
| Wei, L | 1 |
| Ou, Y | 1 |
| Duhaut, DE | 1 |
| Heurteaux, C | 1 |
| Gandin, C | 1 |
| Ichai, C | 1 |
| Quintard, H | 3 |
| Annoni, F | 1 |
| Peluso, L | 1 |
| Gouvêa Bogossian, E | 1 |
| Creteur, J | 2 |
| Zanier, ER | 1 |
| Taccone, FS | 2 |
| Wolahan, SM | 1 |
| Mao, HC | 1 |
| Real, C | 1 |
| Glenn, TC | 2 |
| Mannino, C | 1 |
| Hovda, DA | 1 |
| McArthur, DL | 1 |
| Van Horn, JD | 1 |
| Wright, MJ | 1 |
| Gupta, D | 1 |
| Singla, R | 1 |
| Mazzeo, AT | 1 |
| Schnieder, EB | 1 |
| Tandon, V | 1 |
| Kale, SS | 1 |
| Mahapatra, AK | 1 |
| Zeiler, FA | 1 |
| Thelin, EP | 1 |
| Hutchinson, PJA | 1 |
| Carteron, L | 1 |
| Solari, D | 1 |
| Patet, C | 2 |
| Miroz, JP | 1 |
| Bloch, J | 2 |
| Daniel, RT | 1 |
| Hirt, L | 1 |
| Eckert, P | 1 |
| Magistretti, PJ | 3 |
| Oddo, M | 4 |
| Zhou, T | 1 |
| Kalanuria, A | 1 |
| Lozano, A | 1 |
| Franchi, F | 1 |
| Seastres, RJ | 1 |
| Lheureux, O | 1 |
| Badenes, R | 1 |
| Scolletta, S | 1 |
| Vincent, JL | 1 |
| Ronne-Engström, E | 1 |
| Sala, N | 1 |
| Suys, T | 2 |
| Zerlauth, JB | 2 |
| Marques-Vidal, P | 1 |
| Feihl, F | 1 |
| Messerer, M | 1 |
| Levivier, M | 1 |
| Meuli, R | 2 |
| Pellerin, L | 1 |
| Nordström, CH | 2 |
| Nielsen, TH | 1 |
| Schalén, W | 1 |
| Reinstrup, P | 1 |
| Ungerstedt, U | 1 |
| Khalin, I | 1 |
| Alyautdin, R | 1 |
| Wong, TW | 1 |
| Gnanou, J | 1 |
| Kocherga, G | 1 |
| Kreuter, J | 1 |
| Balança, B | 1 |
| Meiller, A | 1 |
| Bezin, L | 1 |
| Dreier, JP | 1 |
| Marinesco, S | 1 |
| Lieutaud, T | 1 |
| Dienel, GA | 1 |
| Rothman, DL | 1 |
| Dekker, SE | 1 |
| de Vries, HM | 1 |
| Lubbers, WD | 1 |
| van de Ven, PM | 1 |
| Toor, EJ | 1 |
| Bloemers, FW | 1 |
| Geeraedts, LMG | 1 |
| Schober, P | 1 |
| Boer, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury[NCT01573507] | 42 participants (Actual) | Interventional | 2012-03-31 | Completed | |||
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for lactic acid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Lactate infusion as therapeutical intervention: a scoping review.
Topics: Adult; Brain Injuries, Traumatic; Child; Humans; Hypoglycemia; Lactic Acid; Sodium Lactate; Waste Pr | 2022 |
The potential of point-of-care diagnostics to optimise prehospital trauma triage: a systematic review of literature.
Topics: Brain Injuries, Traumatic; Emergency Medical Services; Humans; Lactic Acid; Point-of-Care Systems; P | 2023 |
Brain Protection after Anoxic Brain Injury: Is Lactate Supplementation Helpful?
Topics: Acidosis; Animals; Brain Injuries, Traumatic; Cell Death; Cerebrovascular Circulation; Energy Metabo | 2021 |
A systematic review of cerebral microdialysis and outcomes in TBI: relationships to patient functional outcome, neurophysiologic measures, and tissue outcome.
Topics: Brain Chemistry; Brain Injuries, Traumatic; Glasgow Outcome Scale; Glucose; Glutamic Acid; Humans; L | 2017 |
Cerebral Microdialysis in Neurocritical Care.
Topics: Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Glucose; Humans; Lactic Acid; Microdialysis; | 2018 |
2 trials available for lactic acid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain.
Topics: Adult; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Frontal Lobe; Glucose; Humans; I | 2014 |
Improvement of Neuroenergetics by Hypertonic Lactate Therapy in Patients with Traumatic Brain Injury Is Dependent on Baseline Cerebral Lactate/Pyruvate Ratio.
Topics: Adult; Blood Glucose; Brain Injuries, Traumatic; Energy Metabolism; Female; Humans; Imaging, Three-D | 2016 |
25 other studies available for lactic acid and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Characterising the dynamics of cerebral metabolic dysfunction following traumatic brain injury: A microdialysis study in 619 patients.
Topics: Adult; Arterial Pressure; Brain; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Glucose; Hum | 2021 |
Commentary: Lactate, the Astrocyte-Neuron Lactate Shuttle, and Neuroprotection in Traumatic Brain Injury.
Topics: Astrocytes; Brain; Brain Injuries, Traumatic; Humans; Lactic Acid; Neurons; Neuroprotection | 2022 |
Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level.
Topics: Animals; Brain Injuries, Traumatic; Chalcones; Cyclooxygenase 2; Humans; Lactic Acid; Polyethylene G | 2022 |
To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Choline; Coma; Creatinine; Diffusion Tensor Imaging; Huma | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: a retrospective study.
Topics: Brain Injuries, Traumatic; Glasgow Coma Scale; Humans; Lactic Acid; Prognosis; Retrospective Studies | 2022 |
The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury.
Topics: Abbreviated Injury Scale; Blood Transfusion; Brain Injuries, Traumatic; Humans; Lactic Acid; Retrosp | 2023 |
Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.
Topics: Brain Injuries, Traumatic; Canada; Chromatography, Liquid; Glasgow Outcome Scale; Humans; Lactic Aci | 2023 |
Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Energy Metabolism; Femal | 2020 |
L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Lactic Acid; Male; Neuronal Plast | 2020 |
Targeting higher levels of lactate in the post-injury period following traumatic brain injury.
Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Female; Humans; Lactic Acid; Male; Middle Aged; Pyruvi | 2020 |
Arterial lactate in traumatic brain injury - Relation to intracranial pressure dynamics, cerebral energy metabolism and clinical outcome.
Topics: Adult; Age Factors; Arteries; Biomarkers; Brain Injuries, Traumatic; Cerebrovascular Circulation; En | 2020 |
Hypertonic Sodium Lactate to Alleviate Functional Deficits Following Diffuse Traumatic Brain Injury: An Osmotic or a Lactate-Related Effect?
Topics: Animals; Brain Injuries, Traumatic; Hypertonic Solutions; Lactic Acid; Rats; Saline Solution, Hypert | 2021 |
Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair.
Topics: Animals; Brain Injuries, Traumatic; Lactic Acid; Neurites; Neuronal Outgrowth; Rats; Tissue Scaffold | 2020 |
The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Intracranial Hypertension; Intracranial Pressure; L | 2021 |
Lactate supplementation in severe traumatic brain injured adults by primed constant infusion of sodium L-lactate.
Topics: Adult; Aged; Blood Glucose; Brain; Brain Injuries, Traumatic; Energy Metabolism; Female; Humans; Inf | 2018 |
Acute glucose and lactate metabolism are associated with cognitive recovery following traumatic brain injury.
Topics: Adult; Brain Injuries, Traumatic; Cognition; Energy Metabolism; Frontal Lobe; Glasgow Coma Scale; Gl | 2018 |
Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: A microdialysis study.
Topics: Brain Injuries, Traumatic; Cerebrovascular Circulation; Decompressive Craniectomy; Female; Glasgow O | 2017 |
Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury.
Topics: Adult; Blood Glucose; Brain Injuries, Traumatic; Female; Frontal Lobe; Glasgow Coma Scale; Humans; I | 2018 |
Glucose and Lactate Concentrations in Cerebrospinal Fluid After Traumatic Brain Injury.
Topics: Adult; Aged; Brain; Brain Injuries, Traumatic; Female; Glucose; Humans; Lactic Acid; Male; Middle Ag | 2020 |
High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury.
Topics: Adult; Arterial Pressure; Blood Glucose; Blood Pressure; Brain; Brain Injuries, Traumatic; Cerebrova | 2019 |
Biochemical indications of cerebral ischaemia and mitochondrial dysfunction in severe brain trauma analysed with regard to type of lesion.
Topics: Adult; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Infarction; Energy Metabolism; Female; Gl | 2016 |
Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Brain-Derived Neurotrophic Factor; C | 2016 |
Altered hypermetabolic response to cortical spreading depolarizations after traumatic brain injury in rats.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cerebrovascular Circulation; Cortical Spreading Depressio | 2017 |
Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients.
Topics: Brain; Brain Injuries, Traumatic; Critical Care; Energy Metabolism; Glucose; Humans; Lactic Acid; Mi | 2016 |
Lactate clearance metrics are not superior to initial lactate in predicting mortality in trauma.
Topics: Adult; Biomarkers; Brain Injuries, Traumatic; Female; Glasgow Coma Scale; Humans; Lactic Acid; Male; | 2017 |