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lactic acid and Encephalopathy, Hepatic

lactic acid has been researched along with Encephalopathy, Hepatic in 43 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)."8.31The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023)
"Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure."7.73Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006)
"Hyperammonemia is a consistent finding in many metabolic disorders."5.31The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000)
"This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)."4.31The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023)
"To identify laboratory diagnostic indicators of hepatic encephalopathy (HE), the present study established a HE diagnostic model to explore the diagnostic value of serum homocysteine, lactic acid, procalcitonin, and bile acid levels in HE identification."4.12Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model. ( Chen, F; Li, F; Li, J; Mao, C; Qu, Y; Tian, S; Wang, Y; Zhang, W, 2022)
"Increased brain lactate, and not glutamine, is a primary player in the pathogenesis of brain edema in CLD."3.80Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. ( Bosoi, CR; Huynh, J; Marin, H; Parent-Robitaille, C; Rose, CF; Tremblay, M; Zwingmann, C, 2014)
"Data were collected early after admission and again at the time of onset of grade 3-4 hepatic encephalopathy from acetaminophen-induced fulminant hepatic failure."3.73Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. ( Larsen, FS; Schmidt, LE, 2006)
"Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure."2.50Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014)
" In a separate dose-response experiment cortex from healthy rats was incubated for 120 min in ammonium acetate in concentrations up to 80 mM prior to respirometry."1.46Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. ( Bjerring, PN; Larsen, FS; Witt, AM, 2017)
"We investigated the association between hepatic encephalopathy (HE) scores, abnormal EEG or neuroimaging, and short-term outcome."1.40EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. ( Alonso, E; Goldstein, J; Grimason, M; Hussain, E; Smith, CM; Wainwright, MS; Whitington, PF, 2014)
"Patients with acute liver failure have a disturbed amino acid metabolism and a compromised oxidative metabolism in the brain."1.38The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure. ( Bjerring, PN; Clemmesen, JO; Frederiksen, HJ; Hauerberg, J; Larsen, FS; Nielsen, HB, 2012)
" The quantity of red blood cell infusion, blood loss and the dosage of noradrenalin in encephalopathy group were significantly larger compared with non-encephalopathy group."1.37[Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation]. ( Cai, J; Hei, ZQ; Shen, N; Sun, HY, 2011)
"Fulminant hepatic encephalopathy has a high mortality."1.33Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006)
"Hyperammonemia is a consistent finding in many metabolic disorders."1.31The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro. ( Geraminegad, P; Haghighat, N; McCandless, DW, 2000)
"Patients with severe acute alcoholic hepatitis develop multiple organ failure which is associated with production of inflammatory cytokines and a poor prognosis."1.30Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT. ( Ellis, AJ; Hughes, RD; Langley, PG; Nicholl, D; O'Grady, JG; Wendon, JA; Williams, R, 1999)
"Loss of righting reflex (precoma stage of PSE) was accompanied by 2-3 fold increased CSF lactate and onset of coma by 4-fold increases of lactate (p less than 0."1.28Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy. ( Butterworth, RF; Giguère, JF; Therrien, G, 1991)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19904 (9.30)18.7374
1990's13 (30.23)18.2507
2000's9 (20.93)29.6817
2010's12 (27.91)24.3611
2020's5 (11.63)2.80

Authors

AuthorsStudies
Chen, F1
Li, J1
Zhang, W1
Mao, C1
Wang, Y3
Qu, Y1
Tian, S1
Li, F1
Liu, XF2
Lu, JJ2
Li, Y3
Yang, XY2
Qiang, JW2
Li, H1
Su, HB1
Wang, YG1
Yan, LL1
Peng, YH1
Li, C1
Liu, XY1
Hu, JH1
Ning, P1
Guan, CD1
Simicic, D1
Rackayova, V1
Braissant, O1
Toso, C1
Oldani, G1
Sessa, D1
McLin, VA1
Cudalbu, C1
Chavarria, L1
Cordoba, J1
Oria, M1
Jalan, R1
Hussain, E1
Grimason, M1
Goldstein, J1
Smith, CM1
Alonso, E1
Whitington, PF1
Wainwright, MS1
Bosoi, CR2
Zwingmann, C2
Marin, H1
Parent-Robitaille, C1
Huynh, J1
Tremblay, M1
Rose, CF3
Hertz, L1
Song, D1
Peng, L1
Chen, Y1
Witt, AM1
Larsen, FS4
Bjerring, PN2
Mei, L1
Qiang, J1
Ju, S1
Zhao, S1
Bengmark, S1
Cai, J1
Sun, HY1
Shen, N1
Hei, ZQ1
Rama Rao, KV1
Norenberg, MD1
Hauerberg, J1
Frederiksen, HJ1
Nielsen, HB1
Clemmesen, JO2
Chatauret, N2
Leibfritz, D1
Butterworth, RF3
Schmidt, LE1
Hutchinson, PJ1
Gimson, A1
Al-Rawi, PG1
O'Connell, MT1
Czosnyka, M1
Menon, DK1
Waring, MA1
Sun, J3
Woodman, K3
Mears, DC3
Johnston, B3
Jung, SE1
Horvat, M3
Koutalistras, N3
Watson, KJ2
Sheil, AG3
Waring, M2
Wang, LS1
Nyberg, SL2
Cerra, FB1
Gruetter, R2
Watson, J1
Wang, L1
Weisdorf, SA1
Rajanayagan, V1
Terpstra, M1
Merkle, H1
Truwit, CL1
Garwood, M1
Uğurbil, K1
Ellis, AJ1
Hughes, RD1
Nicholl, D1
Langley, PG1
Wendon, JA1
O'Grady, JG1
Williams, R1
Li, M1
Walsh, TS1
McLellan, S1
Mackenzie, SJ1
Lee, A1
Haghighat, N1
McCandless, DW1
Geraminegad, P1
Høy, CE1
Kondrup, J1
Ott, P1
Blüml, S1
Moreno, A1
Hwang, JH1
Ross, BD1
Rose, C1
Therrien, G2
de Graaf, AA1
Deutz, NE1
Bosman, DK2
Chamuleau, RA2
de Haan, JG1
Bovee, WM2
van Dijk, JE1
Giguère, JF1
Davenport, A1
Davison, AM1
Will, EJ1
Höring, E1
Kubin, S1
von Gaisberg, U1
Yao, H1
Sadoshima, S1
Fujii, K1
Kusuda, K1
Ishitsuka, T1
Tamaki, K1
Fujishima, M1
Zhou, MX1
Chang, TM1
Kleinberger, G1
Gregersen, N1

Reviews

7 reviews available for lactic acid and Encephalopathy, Hepatic

ArticleYear
Magnetic resonance of the brain in chronic and acute liver failure.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl

2014
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
    Metabolic brain disease, 2014, Volume: 29, Issue:4

    Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Precl

2014
Multifactorial Effects on Different Types of Brain Cells Contribute to Ammonia Toxicity.
    Neurochemical research, 2017, Volume: 42, Issue:3

    Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Energy Metabolism; Glutamine; Hepatic Encephalopath

2017
Bio-ecological control of chronic liver disease and encephalopathy.
    Metabolic brain disease, 2009, Volume: 24, Issue:1

    Topics: Dietary Proteins; Feeding Behavior; Food, Formulated; Hepatic Encephalopathy; Humans; Inflammation;

2009
Increase brain lactate in hepatic encephalopathy: cause or consequence?
    Neurochemistry international, 2010, Volume: 57, Issue:4

    Topics: Animals; Biological Transport, Active; Brain Chemistry; Brain Edema; Energy Metabolism; Hepatic Ence

2010
Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy.
    Neurochemistry international, 2012, Volume: 60, Issue:7

    Topics: Acute Disease; Ammonia; Brain; Chronic Disease; Citric Acid Cycle; Energy Metabolism; Glycolysis; He

2012
The acyl-CoA dehydrogenation deficiencies. Recent advances in the enzymic characterization and understanding of the metabolic and pathophysiological disturbances in patients with acyl-CoA dehydrogenation deficiencies.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1985, Volume: 174

    Topics: Acidosis; Acyl Coenzyme A; Acyl-CoA Dehydrogenase, Long-Chain; Ammonia; Carboxylic Acids; Chemical P

1985

Other Studies

36 other studies available for lactic acid and Encephalopathy, Hepatic

ArticleYear
Risk Factor Analysis of Hepatic Encephalopathy and the Establishment of Diagnostic Model.
    BioMed research international, 2022, Volume: 2022

    Topics: Bile Acids and Salts; Factor Analysis, Statistical; Hepatic Encephalopathy; Homocysteine; Humans; La

2022
Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy.
    Metabolic brain disease, 2023, Volume: 38, Issue:5

    Topics: Animals; Arginine; Aspartic Acid; Brain; Glutamic Acid; Glycine; Hepatic Encephalopathy; Iron; Lacti

2023
[Analysis of the clinical predictive value of lactate on the prognosis of patients with acute-on-chronic liver failure combined with infection].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2023, Mar-20, Volume: 31, Issue:3

    Topics: Acute-On-Chronic Liver Failure; Bilirubin; Hepatic Encephalopathy; Humans; Lactic Acid; Prognosis; R

2023
Neurometabolic changes in a rat pup model of type C hepatic encephalopathy depend on age at liver disease onset.
    Metabolic brain disease, 2023, Volume: 38, Issue:6

    Topics: Adult; Animals; Brain; Child; Glutamine; Hepatic Encephalopathy; Humans; Lactic Acid; Liver Diseases

2023
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut

2023
Brain lactate in hepatic encephalopathy: friend or foe?
    Journal of hepatology, 2014, Volume: 60, Issue:3

    Topics: Animals; Brain; Brain Edema; Hepatic Encephalopathy; Lactic Acid; Liver Diseases; Male

2014
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure.
    Journal of pediatric gastroenterology and nutrition, 2014, Volume: 58, Issue:4

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Electroencephalography;

2014
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.
    Journal of hepatology, 2014, Volume: 60, Issue:3

    Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Glutamine; Hepatic Encephalopathy; Lactic Aci

2014
Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity.
    Metabolic brain disease, 2017, Volume: 32, Issue:2

    Topics: Animals; Biosensing Techniques; Brain Chemistry; Cerebral Cortex; Citric Acid Cycle; Encephalitis; H

2017
Magnetic Resonance Spectroscopy for Evaluating Portal-Systemic Encephalopathy in Patients with Chronic Hepatic Schistosomiasis Japonicum.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:12

    Topics: Aged; Aged, 80 and over; Ammonia; Brain; Chronic Disease; Female; Globus Pallidus; Glutamine; Hepati

2016
[Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation].
    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2011, Volume: 23, Issue:7

    Topics: Adult; Blood Glucose; Brain; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Liver Transplantat

2011
The effect of fractionated plasma separation and adsorption on cerebral amino acid metabolism and oxidative metabolism during acute liver failure.
    Journal of hepatology, 2012, Volume: 57, Issue:4

    Topics: Adult; Amino Acids; Cerebrum; Dialysis Solutions; Extracorporeal Circulation; Female; Glutamine; Hep

2012
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:2

    Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa

2003
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure.
    Critical care medicine, 2006, Volume: 34, Issue:2

    Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Child; Female; Hepatic Encephalopa

2006
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
    Neurocritical care, 2006, Volume: 5, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra

2006
Microdialysis in the management of hepatic encephalopathy.
    Neurocritical care, 2006, Volume: 5, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro

2006
Metabolic aspects of cultured hepatocytes for use in a bioartificial liver support system.
    Transplantation proceedings, 1995, Volume: 27, Issue:6

    Topics: Ammonia; Animals; Artificial Organs; Blood Proteins; Capsules; Cells, Cultured; Culture Media; Fibri

1995
Preclinical trial of a bioartificial liver support system in a porcine fulminant hepatic failure model.
    The Australian and New Zealand journal of surgery, 1996, Volume: 66, Issue:8

    Topics: Amino Acids; Ammonia; Animals; Artificial Organs; Extracorporeal Circulation; Fibrinogen; Hepatic En

1996
Brain lactate by magnetic resonance spectroscopy during fulminant hepatic failure in the dog.
    Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1998, Volume: 4, Issue:2

    Topics: Animals; Biomarkers; Brain; Dogs; Dose-Response Relationship, Drug; Feasibility Studies; Galactosami

1998
Positive biochemical effects of a bioartificial liver support system (BALSS) in a porcine fulminant hepatic failure (FHF) model.
    The International journal of artificial organs, 1998, Volume: 21, Issue:1

    Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Bioreactors; Cell Adhesion; Cells, Cultured;

1998
Resolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1998, Volume: 135, Issue:1

    Topics: Adult; Amino Acids; Animals; Brain Chemistry; Dogs; Hepatic Encephalopathy; Humans; Image Processing

1998
Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT.
    The International journal of artificial organs, 1999, Volume: 22, Issue:1

    Topics: Acute Disease; Adult; Ammonia; Biocompatible Materials; Blood Coagulation; Cytokines; Female; Hepati

1999
[Liver support effect of experimental extracorporeal bioartificial liver].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 1999, Volume: 7, Issue:1

    Topics: Animals; Cells, Cultured; Dogs; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Liver, Artifici

1999
Hyperlactatemia and pulmonary lactate production in patients with fulminant hepatic failure.
    Chest, 1999, Volume: 116, Issue:2

    Topics: Critical Illness; Female; Hepatic Encephalopathy; Humans; Lactic Acid; Lung; Male; Prospective Studi

1999
The effect of ammonium chloride on metabolism of primary neurons and neuroblastoma cells in vitro.
    Metabolic brain disease, 2000, Volume: 15, Issue:2

    Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Brain; Cell Death; Energy Metabolism; Female; Fe

2000
Splanchnic metabolism of fuel substrates in acute liver failure.
    Journal of hepatology, 2000, Volume: 33, Issue:6

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acute Kidney Injury; Adult; Blood Glucose; Female; Hepatic Enc

2000
1-(13)C glucose magnetic resonance spectroscopy of pediatric and adult brain disorders.
    NMR in biomedicine, 2001, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Canavan Disease; Carbon Isotopes; Chi

2001
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
    Metabolic brain disease, 2001, Volume: 16, Issue:1-2

    Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce

2001
The use of in vivo proton NMR to study the effects of hyperammonemia in the rat cerebral cortex.
    NMR in biomedicine, 1991, Volume: 4, Issue:1

    Topics: Ammonia; Animals; Cerebral Cortex; Choline; Glutamates; Glutamic Acid; Glutamine; Hepatic Encephalop

1991
A localized in vivo detection method for lactate using zero quantum coherence techniques.
    Magnetic resonance in medicine, 1991, Volume: 22, Issue:2

    Topics: Animals; Brain; Hepatic Encephalopathy; In Vitro Techniques; Lactates; Lactic Acid; Magnetic Resonan

1991
Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy.
    Metabolic brain disease, 1991, Volume: 6, Issue:4

    Topics: Animals; Coma; Energy Metabolism; Hepatic Encephalopathy; Lactates; Lactic Acid; Male; Postural Bala

1991
The prognostic use of a lactate infusion in patients with severe hepatorenal failure.
    Renal failure, 1991, Volume: 13, Issue:2-3

    Topics: Adult; Aged; Female; Hemofiltration; Hepatic Encephalopathy; Humans; Kidney Failure, Chronic; Lactat

1991
[Spontaneous bacterial peritonitis: studies of the incidence and clinical and laboratory chemical parameters].
    Zeitschrift fur Gastroenterologie, 1990, Volume: 28, Issue:7

    Topics: Ascitic Fluid; Bacterial Infections; Bacteriological Techniques; Blood Glucose; Blood Proteins; Chol

1990
Cerebrospinal fluid lactate in patients with hepatic encephalopathy.
    European neurology, 1987, Volume: 27, Issue:3

    Topics: Acid-Base Equilibrium; Brain; Carbon Dioxide; Female; Glycolysis; Hepatic Encephalopathy; Humans; La

1987
Effects of polylactic acid microcapsules containing prostaglandin E2 on the survival rates of grade II coma galactosamine induced fulminant hepatic failure rats.
    Biomaterials, artificial cells, and artificial organs, 1987, Volume: 15, Issue:3

    Topics: Animals; Capsules; Delayed-Action Preparations; Dinoprostone; Galactosamine; Hepatic Encephalopathy;

1987
[Assessment of liver function by metabolic parameters].
    Klinische Anasthesiologie und Intensivtherapie, 1987, Volume: 34

    Topics: Amino Acids; Blood Glucose; Blood Proteins; Critical Care; Energy Metabolism; Hepatic Encephalopathy

1987