lactic acid has been researched along with Encephalomyopathies, Mitochondrial in 32 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this research was to report results on long-term administration of dichloroacetate in 36 children with congenital lactic acidosis who participated previously in a controlled trial of this drug." | 9.13 | Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. ( Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E, 2008) |
| "The purpose of this research was to report results on long-term administration of dichloroacetate in 36 children with congenital lactic acidosis who participated previously in a controlled trial of this drug." | 5.13 | Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate. ( Carney, PR; Gilbert, LR; Neiberger, RE; Shuster, JJ; Stacpoole, PW; Theriaque, DW; Valenstein, E, 2008) |
| " Among them, there were 19 cases of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), 2 cases of encephalopathies which could not be classified into any specific type, 2 cases of floppy infants, one case of Kearns-Sayer syndrome (KSS) and one case of mitochondrial entero-myopathy." | 3.73 | [Phenotype heterogeneity associated with mitochondrial DNA A3243G mutation]. ( Niu, SL; Pei, P; Qi, Y; Wang, ZX; Xu, YF; Yang, YL; Yuan, Y; Zhang, Y, 2005) |
| "Characteristics of myoclonic epilepsy associated with ragged-red fibers include myoclonic epilepsy, generalized epilepsy, hearing loss, exercise intolerance, lactic acidosis, and ragged-red fibers." | 1.35 | Myoclonic epilepsy with ragged-red fibers without increased lactate levels. ( Kimura, S; Kosuge, H; Nakamura, K; Nomura, K; Ozasa, S, 2009) |
| "Five females with mitochondrial encephalomyopathies were treated for 3 to 7 years with a xanthine oxidase inhibitor (allopurinol, oral route, 20 mg/kg/day, in 2 or 3 doses daily)." | 1.33 | Treatment of mitochondrial encephalomyopathies with a xanthine oxidase inhibitor. ( Blanco-Barca, MO; Camiña, F; Castro-Gago, M; Eirís-Puñal, J; Gómez-Lado, C; Novo-Rodríguez, MI; Rodríguez-Segade, S, 2006) |
| "Mitochondrial diseases are a group of inherited disorders caused by a derangement of mitochondrial respiration." | 1.32 | Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease. ( Barker, PB; Crawford, TO; Lin, DD, 2003) |
| "The mitochondrial encephalomyopathies are chronic progressive disorders affecting predominantly the neuromuscular system." | 1.32 | Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies. ( Hanefeld, FA; Hobbiebrunken, E; Komura, K; Wilichowski, EK, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (46.88) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Baheerathan, A | 1 |
| Pitceathly, RD | 1 |
| Curtis, C | 1 |
| Davies, NW | 1 |
| Li, X | 1 |
| Peng, B | 1 |
| Hou, C | 1 |
| Li, J | 1 |
| Zeng, Y | 1 |
| Wu, W | 1 |
| Liao, Y | 1 |
| Tian, Y | 1 |
| Chen, WX | 1 |
| Toi, T | 1 |
| Nomura, Y | 1 |
| Kishino, A | 1 |
| Shigihara, S | 1 |
| Oshima, T | 1 |
| Ishikawa, H | 1 |
| Kamei, S | 1 |
| Miyazaki, H | 1 |
| Nogueira, C | 1 |
| Marques, JS | 1 |
| Nesti, C | 1 |
| Azevedo, L | 1 |
| Di Lullo, M | 1 |
| Meschini, MC | 1 |
| Orlacchio, A | 1 |
| Santorelli, FM | 1 |
| Vilarinho, L | 1 |
| Kimura, S | 1 |
| Ozasa, S | 1 |
| Nakamura, K | 1 |
| Nomura, K | 1 |
| Kosuge, H | 1 |
| Schulte-Mattler, WJ | 1 |
| Müller, T | 1 |
| Deschauer, M | 1 |
| Gellerich, FN | 1 |
| Iaizzo, PA | 1 |
| Zierz, S | 1 |
| Lin, DD | 1 |
| Crawford, TO | 1 |
| Barker, PB | 1 |
| Komura, K | 1 |
| Hobbiebrunken, E | 1 |
| Wilichowski, EK | 1 |
| Hanefeld, FA | 1 |
| Zhang, Y | 1 |
| Wang, ZX | 1 |
| Niu, SL | 1 |
| Xu, YF | 1 |
| Pei, P | 1 |
| Yuan, Y | 1 |
| Yang, YL | 1 |
| Qi, Y | 1 |
| Sperl, W | 1 |
| Jesina, P | 1 |
| Zeman, J | 1 |
| Mayr, JA | 1 |
| Demeirleir, L | 1 |
| VanCoster, R | 1 |
| Pícková, A | 1 |
| Hansíková, H | 1 |
| Houst'ková, H | 1 |
| Krejcík, Z | 1 |
| Koch, J | 1 |
| Smet, J | 1 |
| Muss, W | 1 |
| Holme, E | 1 |
| Houstek, J | 1 |
| Castro-Gago, M | 2 |
| Blanco-Barca, MO | 1 |
| Novo-Rodríguez, MI | 2 |
| Gómez-Lado, C | 1 |
| Camiña, F | 1 |
| Eirís-Puñal, J | 2 |
| Rodríguez-Segade, S | 1 |
| Walia, A | 1 |
| Thapa, BR | 1 |
| Kim, V | 1 |
| Bianchi, MC | 1 |
| Sgandurra, G | 1 |
| Tosetti, M | 1 |
| Battini, R | 1 |
| Cioni, G | 1 |
| José da Rocha, A | 1 |
| Túlio Braga, F | 1 |
| Carlos Martins Maia, A | 1 |
| Jorge da Silva, C | 1 |
| Toyama, C | 1 |
| Pereira Pinto Gama, H | 1 |
| Kok, F | 1 |
| Rodrigues Gomes, H | 1 |
| Stacpoole, PW | 1 |
| Gilbert, LR | 1 |
| Neiberger, RE | 1 |
| Carney, PR | 1 |
| Valenstein, E | 1 |
| Theriaque, DW | 1 |
| Shuster, JJ | 1 |
| Jackson, MJ | 1 |
| Schaefer, JA | 1 |
| Johnson, MA | 1 |
| Morris, AA | 1 |
| Turnbull, DM | 1 |
| Bindoff, LA | 1 |
| Agsteribbe, E | 1 |
| Huckriede, A | 1 |
| Veenhuis, M | 1 |
| Ruiters, MH | 1 |
| Niezen-Koning, KE | 1 |
| Skjeldal, OH | 1 |
| Skullerud, K | 1 |
| Gupta, RS | 1 |
| Hallberg, R | 1 |
| van Diggelen, OP | 1 |
| Ozawa, M | 1 |
| Goto, Y | 1 |
| Sakuta, R | 1 |
| Tanno, Y | 1 |
| Tsuji, S | 1 |
| Nonaka, I | 1 |
| Lincke, CR | 1 |
| van den Bogert, C | 1 |
| Nijtmans, LG | 1 |
| Wanders, RJ | 2 |
| Tamminga, P | 1 |
| Barth, PG | 1 |
| Chen, RS | 1 |
| Huang, CC | 1 |
| Chu, NS | 1 |
| Dionisi-Vici, C | 1 |
| Ruitenbeek, W | 1 |
| Fariello, G | 1 |
| Bentlage, H | 1 |
| Schägger, H | 1 |
| Bosman, C | 1 |
| Piantadosi, C | 1 |
| Sabetta, G | 1 |
| Bertini, E | 1 |
| Schmidt, M | 1 |
| Kunkel, M | 1 |
| Schuff-Werner, P | 1 |
| Naumann, M | 1 |
| Reichmann, H | 1 |
| Reimers, CD | 1 |
| Bowen, J | 1 |
| Richards, T | 1 |
| Maravilla, K | 1 |
| Argov, Z | 1 |
| Boitier, E | 1 |
| Degoul, F | 1 |
| Desguerre, I | 1 |
| Charpentier, C | 1 |
| François, D | 1 |
| Ponsot, G | 1 |
| Diry, M | 1 |
| Rustin, P | 1 |
| Marsac, C | 1 |
| Haas, RH | 1 |
| Barshop, BA | 1 |
| Artuch, R | 1 |
| Vilaseca, MA | 1 |
| Pineda, M | 1 |
| Sperfeld, A | 1 |
| Vietzke, G | 1 |
| Kleber, FX | 1 |
| Ludolph, AC | 1 |
| DiMauro, S | 1 |
| Bonilla, E | 1 |
| De Vivo, DC | 1 |
| Siciliano, G | 1 |
| Mancuso, M | 1 |
| Pasquali, L | 1 |
| Manca, ML | 1 |
| Tessa, A | 1 |
| Iudice, A | 1 |
| Imataka, G | 1 |
| Yamanouchi, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.[NCT05753228] | 90 participants (Anticipated) | Interventional | 2022-12-09 | Recruiting | |||
| Phase 3 Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:[NCT02616484] | Phase 3 | 34 participants (Actual) | Interventional | 2020-07-14 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for lactic acid and Encephalomyopathies, Mitochondrial
| Article | Year |
|---|---|
CSF lactate.
Topics: Adult; Biomarkers; Brain Diseases; Central Nervous System Infections; Enterovirus; Female; Humans; L | 2020 |
Brain magnetic resonance in the diagnostic evaluation of mitochondrial encephalopathies.
Topics: Brain; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mitochondri | 2007 |
Lactate detection by MRS in mitochondrial encephalopathy: optimization of technical parameters.
Topics: Brain Diseases, Metabolic, Inborn; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Mitochondri | 2008 |
Functional evaluation techniques in mitochondrial disorders.
Topics: Evaluation Studies as Topic; Exercise Test; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Mi | 1998 |
[Mitochondrial encephalomyopathies starting in childhood and adolescence].
Topics: Adolescent; Child; DNA, Mitochondrial; Humans; Infant; Lactic Acid; Male; Mitochondrial Encephalomyo | 1998 |
[Coenzyme Q10 deficiency].
Topics: Coenzymes; Diagnosis, Differential; Humans; Lactic Acid; Mitochondria; Mitochondrial Diseases; Mitoc | 2002 |
2 trials available for lactic acid and Encephalomyopathies, Mitochondrial
| Article | Year |
|---|---|
Evaluation of long-term treatment of children with congenital lactic acidosis with dichloroacetate.
Topics: Acidosis, Lactic; Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dichloroacetic A | 2008 |
Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind, crossover study.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Coenzymes; Cross-Over Studies; Double-Blind Met | 1997 |
24 other studies available for lactic acid and Encephalomyopathies, Mitochondrial
| Article | Year |
|---|---|
Novel compound heterozygous TARS2 variants in a Chinese family with mitochondrial encephalomyopathy: a case report.
Topics: Asian People; Developmental Disabilities; Epilepsy; Family; Gene Expression; Heterozygote; High-Thro | 2020 |
Repeated Attacks of Dizziness Caused by a Rare Mitochondrial Encephalomyopathy.
Topics: Administration, Oral; Adult; Biopsy; Caloric Tests; Diagnosis, Differential; Dizziness; Female; Huma | 2018 |
Identification of maternal uniparental isodisomy of chromosome 10 in a patient with mitochondrial DNA depletion syndrome.
Topics: Brain; Chromosome Aberrations; Chromosomes, Human, Pair 10; DNA, Mitochondrial; Humans; Intestinal P | 2013 |
Myoclonic epilepsy with ragged-red fibers without increased lactate levels.
Topics: Adolescent; Anticonvulsants; Diagnosis, Differential; DNA Mutational Analysis; DNA, Mitochondrial; E | 2009 |
Increased metabolic muscle fatigue is caused by some but not all mitochondrial mutations.
Topics: Action Potentials; Adolescent; Adult; Enzymes; Female; Humans; Lactic Acid; Male; Middle Aged; Mitoc | 2003 |
Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease.
Topics: Adolescent; Adult; Brain; Brain Diseases, Metabolic, Inborn; Child; Child, Preschool; Female; Fourie | 2003 |
Effectiveness of creatine monohydrate in mitochondrial encephalomyopathies.
Topics: Adolescent; Adult; Child; Creatine; Exercise Test; Female; Humans; Lactic Acid; Male; MELAS Syndrome | 2003 |
[Phenotype heterogeneity associated with mitochondrial DNA A3243G mutation].
Topics: Adolescent; Adult; Child; Child, Preschool; DNA, Mitochondrial; Female; Humans; Infant; Kearns-Sayre | 2005 |
Deficiency of mitochondrial ATP synthase of nuclear genetic origin.
Topics: Adenosine Triphosphate; Adolescent; Age of Onset; Cardiomyopathy, Hypertrophic, Familial; Cell Nucle | 2006 |
Treatment of mitochondrial encephalomyopathies with a xanthine oxidase inhibitor.
Topics: Adenine Nucleotides; Allopurinol; Child; Child, Preschool; Drug Administration Schedule; Energy Meta | 2006 |
Mitochondrial neuro-gastrointestinal encephalopathy syndrome.
Topics: Biopsy; Child; Diagnosis, Differential; Gastrointestinal Diseases; Humans; Intestinal Pseudo-Obstruc | 2006 |
Presentation and clinical investigation of mitochondrial respiratory chain disease. A study of 51 patients.
Topics: Adolescent; Adult; Alanine; Brain; Child; Creatine Kinase; DNA, Mitochondrial; Electroencephalograph | 1995 |
A fatal, systemic mitochondrial disease with decreased mitochondrial enzyme activities, abnormal ultrastructure of the mitochondria and deficiency of heat shock protein 60.
Topics: Cells, Cultured; Female; Fibroblasts; Glucose; Heat-Shock Proteins; Humans; Infant, Newborn; Lactate | 1993 |
The 8,344 mutation in mitochondrial DNA: a comparison between the proportion of mutant DNA and clinico-pathologic findings.
Topics: Adolescent; Adult; Base Sequence; Child; Child, Preschool; DNA Mutational Analysis; DNA, Mitochondri | 1995 |
Cerebellar hypoplasia in respiratory chain dysfunction.
Topics: Cerebellum; Consanguinity; Cytochrome-c Oxidase Deficiency; Fatal Outcome; Female; Humans; Infant, N | 1996 |
New familial mitochondrial encephalopathy with macrocephaly, cardiomyopathy, and complex I deficiency.
Topics: Cardiomyopathies; Electrophoresis, Gel, Two-Dimensional; Family Health; Fatal Outcome; Fibroblasts; | 1997 |
[Standardized aerobic walking on the treadmill by healthy probands and patients with mitochondrial and non-mitochondrial myopathies].
Topics: Adult; Energy Metabolism; Exercise Test; Female; Humans; Lactic Acid; Male; Middle Aged; Mitochondri | 1997 |
MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA.
Topics: Adult; Amino Acid Substitution; Aspartic Acid; Basal Ganglia; Base Sequence; Brain; Cerebral Cortex; | 1998 |
A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency.
Topics: Cerebellar Ataxia; Child, Preschool; Coenzymes; Electron Transport; Epilepsy; Humans; Kinetics; Lact | 1998 |
Diet change in the management of metabolic encephalomyopathies.
Topics: Adolescent; Adult; Child; Dietary Carbohydrates; Fasting; Fructose; Glucose Tolerance Test; Humans; | 1998 |
Biochemical monitoring of the treatment in paediatric patients with mitochondrial disease.
Topics: Adolescent; Alanine; Ascorbic Acid; Carnitine; Child; Child, Preschool; Erythrocytes; Female; Humans | 1998 |
[Spiroergometry in diagnosis of mitochondrial diseases].
Topics: Adolescent; Adult; Anaerobic Threshold; Diagnosis, Differential; Exercise Test; Female; Humans; Lact | 1999 |
Does the patient have a mitochondrial encephalomyopathy?
Topics: Diagnosis, Differential; DNA Mutational Analysis; DNA, Mitochondrial; Electron Transport; Humans; La | 1999 |
Abnormal levels of human mitochondrial transcription factor A in skeletal muscle in mitochondrial encephalomyopathies.
Topics: Adult; Aged; DNA Mutational Analysis; DNA-Binding Proteins; DNA, Mitochondrial; Energy Metabolism; F | 2000 |