lactic acid has been researched along with Encephalomyelitis, Subacute Necrotizing in 33 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis." | 7.67 | Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985) |
| " Other mitochondrial diseases are characterized by focal brain lesions, which is a core feature of MELAS syndrome (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes)." | 5.41 | Neuroimaging in mitochondrial disease. ( Distelmaier, F; Klopstock, T, 2023) |
| "A 6-month-old female infant with hypotonia and keto and lactic acidosis was diagnosed with lipoamide dehydrogenase (E3) deficiency." | 3.69 | Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate. ( Craigen, WJ, 1996) |
| "An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis." | 3.67 | Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985) |
| "Lip cyanosis is an important initial symptom in LS." | 1.72 | Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report. ( Cao, L; Feng, J; Huang, W; Men, L; Sun, R; Xu, J; Xu, M; Zhao, X, 2022) |
| "Leigh syndrome is a mitochondrial disease caused by respiratory chain deficiency, and there are no proven effective therapies." | 1.48 | Japanese Leigh syndrome case treated with EPI-743. ( Goto, T; Iai, M; Klein, MB; Kouga, T; Miller, G; Miyauchi, A; Murayama, K; Osaka, H; Shimbo, H; Takagi, M; Yamashita, S, 2018) |
| "Two cases with the diagnosis of Leigh syndrome was clear." | 1.42 | [Clinical characteristics and genetic analysis of two cases with Leigh syndrome with acute pulmonary hemorrhage as predominant manifestation]. ( Danqun, J; Jie, D; Kefei, H; Wenjia, T, 2015) |
| "Leigh syndrome is a rare, progressive encephalomyopathy that represents a spectrum of mitochondrial genetic diseases phenotypically distinct, but with neuroradiological and pathological uniform presentation." | 1.39 | Persistent hyperlactacidaemia: about a clinical case. ( Oliveira, AR; Ramos, J; Valente, R; Ventura, L, 2013) |
| "The prognosis for Leigh syndrome was poor during long-term follow-up." | 1.35 | Leigh syndrome: clinical and neuroimaging follow-up. ( Chen, CC; Chi, CS; Lee, HF; Lee, HJ; Tsai, CR, 2009) |
| "The major cause of PDHc deficiency is a defect in the E1alpha component." | 1.33 | A family with pyruvate dehydrogenase complex deficiency due to a novel C>T substitution at nucleotide position 407 in exon 4 of the X-linked Epsilon1alpha gene. ( Darin, N; De Meirleir, L; Eriksson, JE; Holmberg, E; Holme, E; Lissens, W; Tulinius, M; Wiklund, LM, 2005) |
| "In patients with acute respiratory failure under these circumstances, intravenous ketogenic emulsion therapy is worth consideration." | 1.30 | Adult leigh syndrome: treatment with intravenous soybean oil for acute central respiratory failure. ( Ichikawa, K; Kageyama, Y; Kumagai, R; Miyabayashi, S; Yasui, T, 1999) |
| "We studied a 17-year-old girl with subacute necrotizing encephalomyelopathy (Leigh syndrome)." | 1.27 | Subacute necrotizing encephalomyelopathy (Leigh syndrome) associated with disturbed oxidation of pyruvate, malate and 2-oxoglutarate in muscle and liver. ( Den Hartog, MR; Fischer, JC; Gabreëls, FJ; Janssen, AJ; Renier, WO; Ruitenbeek, W; Slooff, JL; Trijbels, JM; Van Erven, PM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (18.18) | 18.7374 |
| 1990's | 5 (15.15) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 8 (24.24) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Jean, J | 1 |
| Christodoulou, E | 1 |
| Gai, X | 1 |
| Tamrazi, B | 1 |
| Vera, M | 1 |
| Mitchell, WG | 1 |
| Schmidt, RJ | 1 |
| Men, L | 1 |
| Feng, J | 1 |
| Huang, W | 1 |
| Xu, M | 1 |
| Zhao, X | 1 |
| Sun, R | 1 |
| Xu, J | 1 |
| Cao, L | 1 |
| Distelmaier, F | 1 |
| Klopstock, T | 1 |
| Galera-Monge, T | 1 |
| Zurita-Díaz, F | 1 |
| Canals, I | 1 |
| Hansen, MG | 1 |
| Rufián-Vázquez, L | 1 |
| Ehinger, JK | 1 |
| Elmér, E | 1 |
| Martin, MA | 1 |
| Garesse, R | 1 |
| Ahlenius, H | 1 |
| Gallardo, ME | 1 |
| Kouga, T | 1 |
| Takagi, M | 1 |
| Miyauchi, A | 1 |
| Shimbo, H | 1 |
| Iai, M | 1 |
| Yamashita, S | 1 |
| Murayama, K | 1 |
| Klein, MB | 1 |
| Miller, G | 1 |
| Goto, T | 1 |
| Osaka, H | 1 |
| Yu, XL | 1 |
| Yan, CZ | 1 |
| Ji, KQ | 1 |
| Lin, PF | 1 |
| Xu, XB | 1 |
| Dai, TJ | 1 |
| Li, W | 1 |
| Zhao, YY | 1 |
| Takahashi, Y | 1 |
| Kioka, H | 1 |
| Shintani, Y | 1 |
| Ohki, A | 1 |
| Takashima, S | 1 |
| Sakata, Y | 1 |
| Higuchi, T | 1 |
| Saito, S | 1 |
| Oliveira, AR | 1 |
| Valente, R | 1 |
| Ramos, J | 1 |
| Ventura, L | 1 |
| Ching, CK | 1 |
| Mak, CM | 1 |
| Au, KM | 1 |
| Chan, KY | 1 |
| Yuen, YP | 1 |
| Yau, EK | 1 |
| Ma, LC | 1 |
| Chow, HL | 1 |
| Chan, AY | 1 |
| Danqun, J | 1 |
| Jie, D | 1 |
| Wenjia, T | 1 |
| Kefei, H | 1 |
| Haginoya, K | 1 |
| Miyabayashi, S | 3 |
| Kikuchi, M | 1 |
| Kojima, A | 1 |
| Yamamoto, K | 1 |
| Omura, K | 1 |
| Uematsu, M | 1 |
| Hino-Fukuyo, N | 1 |
| Tanaka, S | 1 |
| Tsuchiya, S | 1 |
| Lee, HF | 1 |
| Tsai, CR | 1 |
| Chi, CS | 1 |
| Lee, HJ | 1 |
| Chen, CC | 1 |
| Lagrue, E | 1 |
| Abert, B | 1 |
| Nadal, L | 1 |
| Tabone, L | 1 |
| Bodard, S | 1 |
| Medja, F | 1 |
| Lombes, A | 2 |
| Chalon, S | 1 |
| Castelnau, P | 1 |
| Koga, Y | 1 |
| Povalko, N | 1 |
| Katayama, K | 1 |
| Kakimoto, N | 1 |
| Matsuishi, T | 1 |
| Naito, E | 2 |
| Tanaka, M | 1 |
| Collins, D | 1 |
| Angles, JM | 1 |
| Christodoulou, J | 1 |
| Spielman, D | 1 |
| Lindsay, SA | 1 |
| Boyd, J | 1 |
| Krockenberger, MB | 1 |
| Dey, R | 1 |
| Aral, B | 1 |
| Abitbol, M | 1 |
| Marsac, C | 2 |
| Crimi, M | 1 |
| Papadimitriou, A | 1 |
| Galbiati, S | 1 |
| Palamidou, P | 1 |
| Fortunato, F | 1 |
| Bordoni, A | 1 |
| Papandreou, U | 1 |
| Papadimitriou, D | 1 |
| Hadjigeorgiou, GM | 1 |
| Drogari, E | 1 |
| Bresolin, N | 1 |
| Comi, GP | 1 |
| Tulinius, M | 1 |
| Darin, N | 1 |
| Wiklund, LM | 1 |
| Holmberg, E | 1 |
| Eriksson, JE | 1 |
| Lissens, W | 1 |
| De Meirleir, L | 1 |
| Holme, E | 1 |
| Morava, E | 1 |
| Rodenburg, RJ | 1 |
| Hol, F | 1 |
| de Vries, M | 1 |
| Janssen, A | 1 |
| van den Heuvel, L | 1 |
| Nijtmans, L | 1 |
| Smeitink, J | 1 |
| Kruse, B | 1 |
| Hanefeld, F | 1 |
| Holzbach, U | 1 |
| Wilichowski, E | 1 |
| Christen, HJ | 1 |
| Merboldt, KD | 1 |
| Hänicke, W | 1 |
| Frahm, J | 1 |
| Morris, SA | 1 |
| Harbord, MG | 1 |
| Craigen, WJ | 1 |
| Kumagai, R | 1 |
| Ichikawa, K | 1 |
| Yasui, T | 1 |
| Kageyama, Y | 1 |
| Di Rocco, M | 1 |
| Lamba, LD | 1 |
| Minniti, G | 1 |
| Caruso, U | 1 |
| Ueno, M | 1 |
| Oka, A | 1 |
| Maegaki, Y | 1 |
| Toyoshima, M | 1 |
| Fujiwaki, T | 1 |
| Takeshita, K | 1 |
| Nonaka, I | 1 |
| Detre, JA | 1 |
| Wang, ZY | 1 |
| Bogdan, AR | 1 |
| Gusnard, DA | 1 |
| Bay, CA | 1 |
| Bingham, PM | 1 |
| Zimmerman, RA | 1 |
| Ogier, H | 1 |
| Scholte, HR | 1 |
| Poll-The, BT | 1 |
| Fardeau, M | 1 |
| Alcardi, J | 1 |
| Vignes, B | 1 |
| Niaudet, P | 1 |
| Saudubray, JM | 1 |
| Ito, T | 1 |
| Narisawa, K | 1 |
| Iinuma, K | 1 |
| Tada, K | 1 |
| Stansbie, D | 1 |
| Wallace, SJ | 1 |
| Ohama, E | 1 |
| Ikuta, F | 1 |
| Nakamura, N | 1 |
| Van Erven, PM | 1 |
| Gabreëls, FJ | 1 |
| Ruitenbeek, W | 1 |
| Den Hartog, MR | 1 |
| Fischer, JC | 1 |
| Renier, WO | 1 |
| Trijbels, JM | 1 |
| Slooff, JL | 1 |
| Janssen, AJ | 1 |
| Kluitmann, G | 1 |
| Braumann, HG | 1 |
| Kratz, HW | 1 |
| Liersch, R | 1 |
| Langes, K | 1 |
| Seitz, RJ | 1 |
| Frenzel, H | 1 |
4 reviews available for lactic acid and Encephalomyelitis, Subacute Necrotizing
| Article | Year |
|---|---|
Neuroimaging in mitochondrial disease.
Topics: Brain; Humans; Lactic Acid; Leigh Disease; Magnetic Resonance Imaging; MELAS Syndrome; Mitochondrial | 2023 |
[Complex II (succinate-ubiquinone reductase) deficiency].
Topics: Electron Transport; Electron Transport Complex II; Genes, Recessive; Humans; Lactic Acid; Leigh Dise | 2001 |
Disorders of the pyruvate dehydrogenase complex.
Topics: Acetyl Coenzyme A; Acetyltransferases; Acidosis; Brain; Carbon Dioxide; Child; Child, Preschool; Coe | 1986 |
Mitochondrial abnormalities in choroid plexus of Leigh disease.
Topics: Brain Diseases, Metabolic; Child; Child, Preschool; Choroid Plexus; Female; Humans; Infant; Lactates | 1988 |
29 other studies available for lactic acid and Encephalomyelitis, Subacute Necrotizing
| Article | Year |
|---|---|
m.3685T > C is a novel mitochondrial DNA variant that causes Leigh syndrome.
Topics: DNA, Mitochondrial; Female; Humans; Lactic Acid; Leigh Disease; Mitochondrial Diseases; Mutation; Se | 2022 |
Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report.
Topics: Child; Cyanosis; Disease Progression; Electron Transport Complex I; Humans; Infant; Infant, Newborn; | 2022 |
Mitochondrial Dysfunction and Calcium Dysregulation in Leigh Syndrome Induced Pluripotent Stem Cell Derived Neurons.
Topics: Blotting, Western; Calcium; Cell Proliferation; Cells, Cultured; Electrophysiology; Fluorescent Anti | 2020 |
Japanese Leigh syndrome case treated with EPI-743.
Topics: Antioxidants; Brain; Child, Preschool; Disease Progression; Electron Transport Complex I; Female; Hu | 2018 |
Clinical, Neuroimaging, and Pathological Analyses of 13 Chinese Leigh Syndrome Patients with Mitochondrial DNA Mutations.
Topics: Child; Child, Preschool; Creatine Kinase; Cytochrome-c Oxidase Deficiency; DNA, Mitochondrial; Fasti | 2018 |
Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy.
Topics: Alleles; Animals; Biomarkers; Brain; Disease Models, Animal; Disease Progression; Electron Transport | 2019 |
Persistent hyperlactacidaemia: about a clinical case.
Topics: Brain; Humans; Infant; Lactic Acid; Leigh Disease; Male; Pyruvate Dehydrogenase Complex Deficiency D | 2013 |
A patient with congenital hyperlactataemia and Leigh syndrome: an uncommon mitochondrial variant.
Topics: Acidosis, Lactic; DNA, Mitochondrial; Female; Humans; Infant; Lactic Acid; Leigh Disease; Pyruvic Ac | 2013 |
[Clinical characteristics and genetic analysis of two cases with Leigh syndrome with acute pulmonary hemorrhage as predominant manifestation].
Topics: Brain; Carnitine; DNA, Mitochondrial; Female; Genetic Testing; Hemorrhage; Humans; Infant; Lactic Ac | 2015 |
Efficacy of idebenone for respiratory failure in a patient with Leigh syndrome: a long-term follow-up study.
Topics: Adolescent; Brain Stem; Evoked Potentials, Auditory, Brain Stem; Follow-Up Studies; Humans; Lactic A | 2009 |
Leigh syndrome: clinical and neuroimaging follow-up.
Topics: Adolescent; Brain; Female; Follow-Up Studies; Humans; Infant; Lactic Acid; Leigh Disease; Magnetic R | 2009 |
MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Basal Ganglia Diseases; Diseas | 2009 |
Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene.
Topics: Alanine; Cells, Cultured; Child, Preschool; Dichloroacetic Acid; Electroencephalography; Fibroblasts | 2012 |
Severe subacute necrotizing encephalopathy (Leigh-like syndrome) in American Staffordshire bull terrier dogs.
Topics: Animals; Brain Stem; Dog Diseases; Dogs; Lactic Acid; Leigh Disease; Pyruvic Acid | 2013 |
Pyruvate dehydrogenase deficiency as a result of splice-site mutations in the PDX1 gene.
Topics: Amino Acid Sequence; Base Sequence; Humans; Lactic Acid; Leigh Disease; Molecular Sequence Data; Mut | 2002 |
A new mitochondrial DNA mutation in ND3 gene causing severe Leigh syndrome with early lethality.
Topics: Amino Acid Sequence; Animals; Brain; DNA, Mitochondrial; Electron Transport; Electron Transport Comp | 2004 |
A family with pyruvate dehydrogenase complex deficiency due to a novel C>T substitution at nucleotide position 407 in exon 4 of the X-linked Epsilon1alpha gene.
Topics: Amino Acid Substitution; Brain; Carnitine; Child, Preschool; Exons; Humans; Infant; Lactic Acid; Lei | 2005 |
Clinical and biochemical characteristics in patients with a high mutant load of the mitochondrial T8993G/C mutations.
Topics: Adenosine Triphosphate; Alanine; Basal Ganglia Diseases; Child; Child, Preschool; DNA, Mitochondrial | 2006 |
Proton spectroscopy in patients with Leigh's disease and mitochondrial enzyme deficiency.
Topics: Brain Chemistry; Humans; Infant; Lactates; Lactic Acid; Leigh Disease; Magnetic Resonance Spectrosco | 1994 |
Infant onset subacute necrotizing encephalomyelopathy (Leigh's disease)
Topics: Apnea; Blindness; Female; Humans; Infant; Lactates; Lactic Acid; Leigh Disease; Male; Seizures | 1993 |
Leigh disease with deficiency of lipoamide dehydrogenase: treatment failure with dichloroacetate.
Topics: Acidosis, Lactic; Amino Acids, Branched-Chain; Child, Preschool; Dichloroacetic Acid; Dihydrolipoami | 1996 |
Adult leigh syndrome: treatment with intravenous soybean oil for acute central respiratory failure.
Topics: Acute Disease; Adult; Diet; Fat Emulsions, Intravenous; Female; Humans; Injections, Intravenous; Ket | 1999 |
Outcome of thiamine treatment in a child with Leigh disease due to thiamine-responsive pyruvate dehydrogenase deficiency.
Topics: Child; Diagnosis, Differential; Dose-Response Relationship, Drug; Fibroblasts; Follow-Up Studies; Hu | 2000 |
[Mitochondrial DNA T to G mutation 8993 in Leigh encephalopathy and organic aciduria].
Topics: DNA, Mitochondrial; Female; Humans; Infant; Ketoglutaric Acids; Lactic Acid; Leigh Disease; Magnetic | 2001 |
Regional variation in brain lactate in Leigh syndrome by localized 1H magnetic resonance spectroscopy.
Topics: Brain; Female; Humans; Hydrogen; Infant; Lactates; Lactic Acid; Leigh Disease; Magnetic Resonance Im | 1991 |
de Toni-Fanconi-Debré syndrome with Leigh syndrome revealing severe muscle cytochrome c oxidase deficiency.
Topics: Brain Diseases, Metabolic; Child, Preschool; Cytochrome-c Oxidase Deficiency; Fanconi Syndrome; Fema | 1988 |
Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy.
Topics: Acidosis; Adolescent; Brain Diseases, Metabolic; Carboxy-Lyases; Cells, Cultured; Child; Child, Pres | 1985 |
Subacute necrotizing encephalomyelopathy (Leigh syndrome) associated with disturbed oxidation of pyruvate, malate and 2-oxoglutarate in muscle and liver.
Topics: Adolescent; Brain; Brain Diseases, Metabolic; Enzymes; Female; Humans; Ketoglutaric Acids; Lactates; | 1985 |
[Acute course of Leigh syndrome with hypertrophic cardiomyopathy in a female infant].
Topics: Acidosis; Amino Acids; Brain Diseases, Metabolic; Cardiac Tamponade; Cardiomyopathy, Hypertrophic; D | 1985 |