Page last updated: 2024-10-17

lactic acid and Emesis

lactic acid has been researched along with Emesis in 15 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Gastric beriberi is a rare presentation of TD that can lead to severe GI symptoms and lactic acidosis."8.12Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi. ( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
"Gastric beriberi is a rare presentation of TD that can lead to severe GI symptoms and lactic acidosis."4.12Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi. ( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
" His blood gas analysis showed a metabolic acidosis caused by renal failure and lactic acidosis combined with a hypochloraemic alkalosis."3.73[A mixed acid-base disorder revealing a cystic dystrophy of aberrant pancreatic tissue]. ( Bedock, B; Dumaine, A; Gauclère, V; Legrand, E; Proust, P; Rozière, A; Tayssir, A, 2006)
"Manifestations suggestive of migraine were present in each child."2.40Mitochondrial disease and cyclic vomiting syndrome. ( Boles, RG; Williams, JC, 1999)
" Adverse events included rising serum lactate (30."1.39Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy. ( Mancl, EE; Muzevich, KM, 2013)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's3 (20.00)29.6817
2010's7 (46.67)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Nisar, S1
Tanvir, M1
Ganie, MA1
Kareem, O1
Muzaffer, U1
Wani, IA1
Nuzzo, A1
Joly, F1
Ronot, M1
Castier, Y1
Huguet, A1
Paugam-Burtz, C1
Cazals-Hatem, D1
Tran-Dinh, A1
Becq, A1
Panis, Y1
Bouhnik, Y1
Maggiori, L1
Corcos, O1
Parente, CS1
Sandland-Taylor, LE1
Akhtar, W1
Kalantar-Zadeh, K1
Uppot, RN1
Lewandrowski, KB1
Baur, DA1
Schroer, AB1
Luden, ND1
Womack, CJ1
Smyth, SA1
Saunders, MJ1
Thanachartwet, V1
Oer-Areemitr, N1
Chamnanchanunt, S1
Sahassananda, D1
Jittmittraphap, A1
Suwannakudt, P1
Desakorn, V1
Wattanathum, A1
Beharrysingh, R1
McDaniel, JL1
Abdel Hak, A1
Voore, N1
Abandeh, FI1
Young, DS1
Miller, ES1
Bhatia, K1
Mancl, EE1
Muzevich, KM1
Zouaoui, K1
Dulaurent, S1
Gaulier, JM1
Moesch, C1
Lachâtre, G1
Lichterfeld, M1
Fischer, HP1
Spengler, U1
Rockstroh, JK1
Dumaine, A1
Tayssir, A1
Gauclère, V1
Proust, P1
Legrand, E1
Rozière, A1
Bedock, B1
McTague, JA1
Forney, R1
Boles, RG1
Williams, JC1
Strachan, J1
McLellan, A1
Kirkpatrick, M1
Hume, R1
Mechan, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]Phase 2140 participants (Actual)Interventional2018-02-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Sequential Organ Failure Assessment (SOFA) Score

Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization

Interventionscore on a scale (Mean)
Treatment Arm2.9
Placebo Arm1.93

Hospital Length of Stay

Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.

InterventionDays (Mean)
Treatment Arm11.5
Placebo Arm11

Hospital Mortality

In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm11
Placebo Arm13

ICU Length of Stay

Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.

Interventiondays (Mean)
Treatment Arm4.76
Placebo Arm4.66

ICU Mortality

ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm6
Placebo Arm10

Procalcitonin (PCT) Clearance

PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization

InterventionPercent (Mean)
Treatment Arm63
Placebo Arm58

Time to Vasopressor Independence (Hours)

Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.

Interventionhours (Mean)
HAT Treatment27
Comparator53

Ventilator Free Days

Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization

InterventionDays (Mean)
Treatment Arm22
Placebo Arm22.4

Reviews

2 reviews available for lactic acid and Emesis

ArticleYear
Jamaican vomiting sickness in Toledo, Ohio.
    Annals of emergency medicine, 1994, Volume: 23, Issue:5

    Topics: Adipates; Adult; Chromatography, Gas; Emergency Service, Hospital; Female; Fluid Therapy; Fruit; Hum

1994
Mitochondrial disease and cyclic vomiting syndrome.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:8 Suppl

    Topics: Adolescent; Adult; Child; Child, Preschool; DNA Mutational Analysis; DNA, Mitochondrial; Female; Hum

1999

Trials

1 trial available for lactic acid and Emesis

ArticleYear
Glucose-fructose enhances performance versus isocaloric, but not moderate, glucose.
    Medicine and science in sports and exercise, 2014, Volume: 46, Issue:9

    Topics: Administration, Oral; Adult; Athletic Performance; Bicycling; Blood Glucose; Colic; Dizziness; Doubl

2014

Other Studies

12 other studies available for lactic acid and Emesis

ArticleYear
Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi.
    Nutrition (Burbank, Los Angeles County, Calif.), 2022, Volume: 102

    Topics: Adult; Aged; Beriberi; Gastrointestinal Diseases; Humans; Lactic Acid; Middle Aged; Nausea; Thiamine

2022
Normal Lactate and Unenhanced CT-Scan Result in Delayed Diagnosis of Acute Mesenteric Ischemia.
    The American journal of gastroenterology, 2020, Volume: 115, Issue:11

    Topics: Abdominal Pain; Acute Disease; Adult; Anastomosis, Surgical; Chronic Disease; Cohort Studies; Colon;

2020
Diagnostic challenge: an atypical presentation of infective endocarditis.
    BMJ case reports, 2021, Jan-25, Volume: 14, Issue:1

    Topics: Bacteremia; Blood Culture; C-Reactive Protein; Diagnosis, Differential; Diarrhea; Dysentery; Early W

2021
Case records of the Massachusetts General Hospital. Case 23-2013. A 54-year-old woman with abdominal pain, vomiting, and confusion.
    The New England journal of medicine, 2013, Jul-25, Volume: 369, Issue:4

    Topics: Abdominal Pain; Acidosis, Lactic; Confusion; Diabetes Mellitus, Type 2; Diagnosis, Differential; Fem

2013
Identification of clinical factors associated with severe dengue among Thai adults: a prospective study.
    BMC infectious diseases, 2015, Oct-14, Volume: 15

    Topics: Adolescent; Adult; Age Factors; Child; Dengue Virus; Female; Hemorrhage; Humans; Lactic Acid; Logist

2015
A Break in the Wall: Stercoral Colitis.
    The American journal of medicine, 2016, Volume: 129, Issue:5

    Topics: Abdomen; Aged; Cervical Cord; Colitis; Confusion; Fatal Outcome; Fecal Impaction; Female; Hospice Ca

2016
Fever and Malaise in an Infant.
    The Journal of emergency medicine, 2017, Volume: 53, Issue:2

    Topics: Anti-Bacterial Agents; Antimalarials; Babesiosis; Clindamycin; Diagnosis, Differential; Doxycycline;

2017
Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy.
    JPEN. Journal of parenteral and enteral nutrition, 2013, Volume: 37, Issue:5

    Topics: Administration, Intravenous; Adult; Aged; Critical Illness; Dose-Response Relationship, Drug; Entera

2013
Determination of glyphosate and AMPA in blood and urine from humans: about 13 cases of acute intoxication.
    Forensic science international, 2013, Mar-10, Volume: 226, Issue:1-3

    Topics: Accidents; Acidosis; Adult; Aged; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Chro

2013
[Fatty liver and increased serum lactate in a woman with HIV].
    Deutsche medizinische Wochenschrift (1946), 2003, Jan-17, Volume: 128, Issue:3

    Topics: Abdominal Pain; Antiretroviral Therapy, Highly Active; Biopsy; Fatty Liver; Female; Hepatomegaly; HI

2003
[A mixed acid-base disorder revealing a cystic dystrophy of aberrant pancreatic tissue].
    Annales francaises d'anesthesie et de reanimation, 2006, Volume: 25, Issue:2

    Topics: Acid-Base Imbalance; Acidosis; Acute Kidney Injury; Adult; Alkalosis; Blood Chemical Analysis; Blood

2006
Ketoacidosis: an unusual presentation of MELAS.
    Journal of inherited metabolic disease, 2001, Volume: 24, Issue:3

    Topics: Blood Glucose; C-Reactive Protein; Cerebral Infarction; Child; Creatinine; Humans; Ketosis; Lactic A

2001