lactic acid has been researched along with Drug Overdose in 28 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury." | 8.31 | Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 7.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| " Laboratory findings showed hypokalemia, hypophosphatemia, and lactic acidosis." | 7.78 | Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone. ( Hantson, P; Manara, A; Thys, F; Vanpee, D, 2012) |
| "This case report of metaproterenol toxicity was associated with hypokalemia, hyperglycemia and hyperlactatemia." | 7.71 | Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia. ( Barnewolt, BA; Bey, TA; Walter, FG, 2001) |
| "The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain." | 4.90 | A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014) |
| "When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury." | 4.31 | Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| " The primary outcomes were: (1) hyperlactatemia, defined as a lactate concentration ≥ 2 mmol/L at any point during hospital admission and, (2) metformin associated lactic acidosis (MALA), defined as a lactate concentration ≥ 5 mmol/L and pH <7." | 3.91 | Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. ( Hoffman, RS; Manini, AF; Taub, ES, 2019) |
| " Hemodialysis appears to be a beneficial therapeutic option in cases of massive acetaminophen ingestion with coma and lactic acidosis." | 3.83 | Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. ( Ghannoum, M; Gosselin, S; Grunbaum, AM; Kazim, S; Villeneuve, E, 2016) |
| " Laboratory findings showed hypokalemia, hypophosphatemia, and lactic acidosis." | 3.78 | Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone. ( Hantson, P; Manara, A; Thys, F; Vanpee, D, 2012) |
| "This case report of metaproterenol toxicity was associated with hypokalemia, hyperglycemia and hyperlactatemia." | 3.71 | Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia. ( Barnewolt, BA; Bey, TA; Walter, FG, 2001) |
| " The principal findings included metabolic acidosis accompanied by an increase in the plasma anion gap that was not caused by L -lactic acidosis, hyperkalemia, and the abrupt onset of hypotension." | 3.71 | Citric acid ingestion: a life-threatening cause of metabolic acidosis. ( DeMars, CS; Halperin, ML; Himmelfarb, J; Hollister, K; Tomassoni, A, 2001) |
| "Metformin is known to cause potentially fatal metabolic acidosis with an increased lactate level in both overdose and therapeutic use." | 2.45 | Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. ( Abramson, J; Dell'Aglio, DM; Kazzi, Z; Morgan, BW; Perino, LJ; Schwartz, MD, 2009) |
| "Respiratory depression was measured using plethysmography." | 1.39 | Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone. ( Morris, ME; Morse, BL, 2013) |
| "Pediatric medication dosing and administration, faced with inherent challenges of dose to body weight adjustment and variable delivery vehicles, may lead to inadvertent errors effectively resulting in overdose." | 1.37 | Zidovudine (AZT) overdose in a healthy newborn receiving postnatal prophylaxis. ( Esteban-Cruciani, N; Hoffman, RS; Lee, S; Livshits, Z; Nelson, LS, 2011) |
| "Since the onset of the influenza A (H1N1) pandemic, AHRs have gained considerable popularity among the general public." | 1.36 | Severe alcohol hand rub overdose inducing coma, watch after H1N1 pandemic. ( Bedos, JP; Ben Mokhtar, H; Bruneel, F; Charbonnier, M; Guezennec, P; Henry-Lagarrigue, M; Legriel, S; Merrer, J; Palette, C; Troche, G; Yehia, A, 2010) |
| " A toxic dose of acetaminophen (800 mg/kg body weight intraperitoneally) induced severe abnormality in all basic parameters with apparent toxicity in liver (enlargement of hepatocytes, loss of cytoplasmic content with disruption in the hepatic plates and sinusoidal dilation) and renal tissue (glomerular damage with congestion of tubules)." | 1.35 | Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats. ( Raghavendran, HR; Srinivasan, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 17 (60.71) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Shastry, S | 1 |
| Manoochehri, O | 1 |
| Richardson, LD | 1 |
| Manini, AF | 4 |
| Trebach, J | 1 |
| Mohan, S | 1 |
| Gnirke, M | 1 |
| Su, MK | 1 |
| Gosselin, S | 2 |
| Hoffman, RS | 5 |
| Hughes, BW | 1 |
| Gray, LA | 1 |
| Bradberry, SM | 1 |
| Sandilands, EA | 1 |
| Thanacoody, RH | 1 |
| Coulson, JM | 1 |
| Goonoo, MS | 1 |
| Morris, R | 1 |
| Raithatha, A | 1 |
| Creagh, F | 1 |
| Young, S | 1 |
| O'Driscoll, R | 1 |
| Antony, M | 1 |
| Whyte, I | 1 |
| Cheung, R | 1 |
| Vlahov, D | 2 |
| Taub, ES | 1 |
| Morse, BL | 3 |
| Morris, ME | 4 |
| Senthilkumaran, S | 1 |
| Shah, S | 1 |
| Menezes, RG | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Vijay, N | 2 |
| Adam, WR | 1 |
| O'Brien, RC | 1 |
| Rothberger, GD | 1 |
| Desai, AK | 1 |
| Sharif, S | 1 |
| Chawla, SA | 1 |
| Shirazian, S | 1 |
| Ghannoum, M | 1 |
| Kazim, S | 1 |
| Grunbaum, AM | 1 |
| Villeneuve, E | 1 |
| Raghavendran, HR | 1 |
| Srinivasan, P | 1 |
| Dell'Aglio, DM | 1 |
| Perino, LJ | 1 |
| Kazzi, Z | 1 |
| Abramson, J | 1 |
| Schwartz, MD | 1 |
| Morgan, BW | 1 |
| Hiller, DB | 1 |
| Gregorio, GD | 1 |
| Ripper, R | 1 |
| Kelly, K | 1 |
| Massad, M | 1 |
| Edelman, L | 1 |
| Edelman, G | 1 |
| Feinstein, DL | 1 |
| Weinberg, GL | 1 |
| Henry-Lagarrigue, M | 1 |
| Charbonnier, M | 1 |
| Bruneel, F | 1 |
| Legriel, S | 1 |
| Troche, G | 1 |
| Ben Mokhtar, H | 1 |
| Yehia, A | 1 |
| Guezennec, P | 1 |
| Merrer, J | 1 |
| Palette, C | 1 |
| Bedos, JP | 1 |
| Kjelland, CB | 1 |
| Djogovic, D | 1 |
| Kumar, A | 1 |
| Olsen, D | 1 |
| Zein, JG | 1 |
| Wallace, DJ | 1 |
| Kinasewitz, G | 1 |
| Toubia, N | 1 |
| Kakoulas, C | 1 |
| Livshits, Z | 1 |
| Lee, S | 1 |
| Nelson, LS | 1 |
| Esteban-Cruciani, N | 1 |
| Manara, A | 1 |
| Hantson, P | 1 |
| Vanpee, D | 1 |
| Thys, F | 1 |
| Roiko, SA | 1 |
| Felmlee, MA | 1 |
| Karlovsek, MZ | 1 |
| Heaney, D | 1 |
| Majid, A | 1 |
| Junor, B | 1 |
| Barnewolt, BA | 1 |
| Walter, FG | 1 |
| Bey, TA | 1 |
| DeMars, CS | 1 |
| Hollister, K | 1 |
| Tomassoni, A | 1 |
| Himmelfarb, J | 1 |
| Halperin, ML | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lactic acid and Drug Overdose
| Article | Year |
|---|---|
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure.
Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat | 2014 |
Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.
Topics: Acidosis, Lactic; Acute Disease; Adult; Drug Overdose; Female; Humans; Hydrogen-Ion Concentration; H | 2009 |
The role of serum lactate in the acute care setting.
Topics: Acidosis, Lactic; Adult; Aged; Antiretroviral Therapy, Highly Active; Biomarkers; Critical Care; Dru | 2010 |
25 other studies available for lactic acid and Drug Overdose
| Article | Year |
|---|---|
Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.
Topics: Adult; Cardiotoxicity; Cocaine; Drug Overdose; Emergency Service, Hospital; Ethanol; Heart Arrest; H | 2023 |
Retrospective evaluation of management guidelines for extracorporeal treatment of metformin poisoning.
Topics: Drug Overdose; Humans; Lactic Acid; Metformin; Renal Dialysis; Retrospective Studies | 2023 |
Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis.
Topics: Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Lactic Acid; Metformin; Poisons; Retro | 2023 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
Massive eucalyptus oil overdose.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidotes; Charcoal; Citalopram; Coma; Drug Overdos | 2017 |
Prognostic Utility of Initial Lactate in Patients With Acute Drug Overdose: A Validation Cohort.
Topics: Adult; Cohort Studies; Drug Overdose; Emergency Service, Hospital; Female; Hospital Mortality; Hospi | 2018 |
Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose.
Topics: Acetaminophen; Acidosis, Lactic; Analgesics, Non-Narcotic; Case-Control Studies; Drug Overdose; Emer | 2019 |
Toxicokinetics/Toxicodynamics of γ-hydroxybutyrate-ethanol intoxication: evaluation of potential treatment strategies.
Topics: Animals; Central Nervous System Depressants; Conscious Sedation; Drug Overdose; Ethanol; GABA-B Rece | 2013 |
Salmeterol and lactic acidosis: clinical and educational aspects.
Topics: Acidosis, Lactic; Albuterol; Androstadienes; Asthma; Drug Overdose; Female; Humans; Intention; Lacti | 2014 |
Mechanistic modeling of monocarboxylate transporter-mediated toxicokinetic/toxicodynamic interactions between γ-hydroxybutyrate and L-lactate.
Topics: Anesthetics, Intravenous; Animals; Computer Simulation; Dose-Response Relationship, Drug; Drug Overd | 2014 |
The Case | Elevated lactate and osmolar gap after levothyroxine overdose.
Topics: Acidosis; Adult; Calcium Oxalate; Delirium; Drug Overdose; Ethylene Glycol; Female; Humans; Lactic A | 2015 |
Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Adolescent; Coma; Drug Overdose; Emergency Service, | 2016 |
Effect of crude sulphated polysaccharide from brown algae against acetaminophen-induced toxicity in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Blood Glucose; Cell Death; Drug Overdose; Globulin | 2008 |
Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Drug Overdose; Electro | 2009 |
Severe alcohol hand rub overdose inducing coma, watch after H1N1 pandemic.
Topics: Adult; Alcoholic Intoxication; Coma; Cross Infection; Disease Outbreaks; Disinfectants; Drug Overdos | 2010 |
Utility of serum lactate to predict drug-overdose fatality.
Topics: Adult; Aged; Carbon Dioxide; Case-Control Studies; Drug Overdose; Emergency Service, Hospital; Femal | 2010 |
Early anion gap metabolic acidosis in acetaminophen overdose.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis, Lactic; Adult; Analgesics, Non-Narcotic; Analysis of | 2010 |
Zidovudine (AZT) overdose in a healthy newborn receiving postnatal prophylaxis.
Topics: Acidosis; Alanine Transaminase; Anti-HIV Agents; Drug Overdose; HIV Infections; Humans; Infant, Newb | 2011 |
Lactic acidosis following intentional overdose by inhalation of salmeterol and fluticasone.
Topics: Acidosis, Lactic; Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Albut | 2012 |
Brain extracellular γ-hydroxybutyrate concentrations are decreased by L-lactate in rats: role in the treatment of overdoses.
Topics: Animals; Brain; Cell Line; Drug Overdose; Humans; Hypnotics and Sedatives; Lactic Acid; Male; Mannit | 2013 |
Effects of monocarboxylate transporter inhibition on the oral toxicokinetics/toxicodynamics of γ-hydroxybutyrate and γ-butyrolactone.
Topics: 4-Butyrolactone; Absorption; Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug O | 2013 |
Diagnostic values of combined glucose and lactate values in cerebrospinal fluid and vitreous humour--our experiences.
Topics: Cerebrospinal Fluid; Drug Overdose; Forensic Medicine; Glucose; Glycated Hemoglobin; Humans; Hypogly | 2004 |
Bicarbonate haemodialysis as a treatment of metformin overdose.
Topics: Acidosis, Lactic; Adult; Bicarbonates; Buffers; Drug Overdose; Humans; Hypoglycemic Agents; Lactic A | 1997 |
Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia.
Topics: Adolescent; Adrenergic beta-Agonists; Bronchodilator Agents; Drug Overdose; Female; Humans; Hypergly | 2001 |
Citric acid ingestion: a life-threatening cause of metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Calcium; Calcium Chloride; Citric Acid; Critical Care; Drug | 2001 |