lactic acid has been researched along with Down Syndrome in 8 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Significant correlations with maternal preeclampsia and fetal open spina bifida were also observed." | 1.29 | Metabolic profiling of amniotic fluid by proton nuclear magnetic resonance spectroscopy: correlation with fetal maturation and other clinical variables. ( Bock, JL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leti, T | 1 |
| Guinot, M | 1 |
| Favre-Juvin, A | 1 |
| Bricout, VA | 1 |
| Aguiar, AS | 1 |
| Tuon, T | 1 |
| Albuquerque, MM | 1 |
| Rocha, GS | 1 |
| Speck, AE | 1 |
| Araújo, JC | 1 |
| Dafré, AL | 1 |
| Prediger, RD | 1 |
| Pinho, RA | 1 |
| Novikov, VD | 1 |
| Valova, TA | 1 |
| Iasakova, NT | 1 |
| Belan, IB | 1 |
| HARTMANN, AF | 1 |
| WOHLTMANN, HJ | 1 |
| PURKERSON, ML | 1 |
| WESLEY, ME | 1 |
| Bock, JL | 1 |
| Vicente Villa, MA | 1 |
| Rueda Muñoz, A | 1 |
| González-Enseñat, MA | 1 |
| Corretger Rauet, J | 1 |
| Medina, M | 1 |
| Palou Aymerich, J | 1 |
| Yao, FS | 1 |
| Caserta, MT | 1 |
| Wyrwicz, AM | 1 |
| Eberhard, Y | 1 |
| Eterradossi, J | 1 |
| Therminarias, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| SLEEP APNEA SYNDROME AND TRISOMY 21 : Exploration of the Predictive Factors in the Population With Trisomy 21[NCT03445962] | 40 participants (Actual) | Observational | 2017-11-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for lactic acid and Down Syndrome
| Article | Year |
|---|---|
Difference of catecholamine responses to exercise in men with trisomy 21, with or without chronotropic incompetence.
Topics: Cardiovascular Diseases; Down Syndrome; Epinephrine; Exercise; Exercise Test; Heart Rate; Humans; In | 2015 |
The exercise redox paradigm in the Down's syndrome: improvements in motor function and increases in blood oxidative status in young adults.
Topics: Adult; Antioxidants; Biomarkers; Brain; Brain Diseases, Metabolic, Inborn; Catalase; Down Syndrome; | 2008 |
[Morphological and functional characteristics of lymphocytes of mothers of children with Down syndrome].
Topics: Adult; Cell Nucleus; Child; Chromatin; Coloring Agents; Cytoplasm; Down Syndrome; Female; Glyceropho | 2000 |
Lactate metabolism. Studies of a child with a serious congenital deviation.
Topics: Acidosis; Child; Disease; Down Syndrome; Humans; Infant; Lactates; Lactic Acid; Medical Records; Res | 1962 |
Metabolic profiling of amniotic fluid by proton nuclear magnetic resonance spectroscopy: correlation with fetal maturation and other clinical variables.
Topics: Amino Acids; Amniotic Fluid; Choline; Creatinine; Down Syndrome; Embryonic and Fetal Development; Fe | 1994 |
[Perforant elastosis serpiginosa associated with Down's syndrome. Report of 2 cases].
Topics: Adolescent; Anti-Inflammatory Agents; Biopsy; Child; Down Syndrome; Elastic Tissue; Female; Humans; | 1998 |
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Ani | 2000 |
Biochemical changes and catecholamine responses in Down's syndrome adolescents in relation to incremental maximal exercise.
Topics: Adolescent; Blood Glucose; Down Syndrome; Energy Metabolism; Epinephrine; Exercise; Exercise Test; F | 1991 |