lactic acid has been researched along with Disease Models, Animal in 1137 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 8.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 8.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 7.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 7.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| "Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear." | 7.85 | Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test. ( Chang, TW; Chen, EL; Chen, MH; Chen, TI; Chiang, YC; Jhang, YS; Lai, SC; Lin, CY; Lin, IH; Seenan, V; Shiung, J; Tseng, YW; Tzeng, YJ, 2017) |
| "To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration." | 7.81 | Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015) |
| " Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)." | 7.81 | Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 7.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "In this study, ifosfamide-loaded poly (lactic-co-glycolic acid) (PLGA)-dextran polymeric nanoparticles (PD/IFS) was developed and studied its anticancer efficacy against multiple osteosarcoma cancer cells." | 7.81 | Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma. ( Chen, B; Lin, XJ; Wang, LF; Yang, JZ; Zhang, YJ, 2015) |
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 7.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| " In this study, we have evaluated anti-asthmatic efficacy of inhalable montelukast-loaded large porous particulate formulations in ovalbumin-induced rat airway inflammation model that mimics asthma." | 7.80 | Aerosolized montelukast polymeric particles-an alternative to oral montelukast-alleviate symptoms of asthma in a rodent model. ( Ahsan, F; Gupta, N; Patel, B, 2014) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 7.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| " The aim of this study was to investigate the effects of hypothyroidism on leucine, mannose, glucose and lactate metabolism in rat cerebellar slices." | 7.79 | Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices. ( da Silveira, CK; de Assis, AM; Farina, M; Longoni, A; Müller, AP; Perry, ML; Souza, DO, 2013) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 7.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| " Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy." | 7.79 | The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013) |
| " Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 7.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
| "Cyclosporine A (CyA) is a useful immunosuppressive agent for steroid-dependent or steroid-refractory ulcerative colitis." | 7.77 | The effective therapy of cyclosporine A with drug delivery system in experimental colitis. ( Fukata, N; Fukui, T; Koyabu, M; Kusuda, T; Matsushita, M; Miyoshi, H; Nishio, A; Okazaki, K; Tabata, Y; Uchida, K, 2011) |
| "To investigate the therapeutic efficacy and optimal drug dose of an intravitreally implantable voriconazole (VCZ) drug delivery system (DDS) in experimental endophthalmitis of Aspergillus fumigatus." | 7.77 | Intravitreally implantable voriconazole delivery system for experimental fungal endophthalmitis. ( Dong, X; Min, X; Wu, X; Xie, L; Yang, L, 2011) |
| "To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model." | 7.77 | Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011) |
| "To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)." | 7.77 | Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011) |
| "We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability." | 7.76 | Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010) |
| "The results of our study showed that rats that had been administered oral carvedilol for several days were more resistant to CA induced by airway obstruction, and when CA did occur, were more likely to be resuscitated." | 7.76 | The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. ( Kurita, A; Taniguchi, T; Yamamoto, K, 2010) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 7.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "Polylactic acid (PLA) patch has proper steric configuration, sufficient mechanic strength, and flexibility, to investigate the blocking effect on the intra-discal inflammation after annulus puncture sticked by medical glue so as to seal the pinhole left after annulus puncture." | 7.76 | [A study on blocking effect of polylactic acid patch on intra-discal inflammation after annulus puncture]. ( Feng, G; Gong, Q; Huang, X; Li, T; Liu, H; Liu, L; Liu, X; Shi, R; Song, Y; Zhang, W; Zhao, X, 2010) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 7.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| "To evaluate the effects of methylene blue (MB) on refractory hemorrhagic shock." | 7.74 | [Effects of methylene blue on refractory hemorrhagic shock]. ( Wang, HL; Wang, Z; Yu, CH; Yu, XZ; Zhu, HD, 2008) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "This study was performed in order to assess the effects of olprinone, a phosphodiesterase III inhibitor, on hepatic oxygen delivery (DO2H), oxygen consumption (VO2H), and mitochondrial oxidation in the liver of a porcine endotoxemia model." | 7.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| " In this study, we evaluated the effects of intravenously administered poly(lactic acid) nanoparticles encapsulating betamethasone phosphate (BP-PLA NPs) on experimental autoimmune uveoretinitis (EAU) in Lewis rats." | 7.73 | Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate. ( Higaki, M; Ishihara, T; Kitahara, K; Kohno, H; Matsushima, M; Mizushima, Y; Saito, S; Sakai, T, 2006) |
| "We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))." | 7.73 | Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006) |
| " It was demonstrated that the intravitreal injection of the optimized CsA-PLGA-MS decreased significantly the severity of the inflammatory signs, cellular infiltrate, aqueous leukocyte counts, and protein levels in the eyes of experimental rabbits with uveitis, compared to other formulations." | 7.73 | Therapeutic and toxicological evaluations of cyclosporine a microspheres as a treatment vehicle for uveitis in rabbits. ( He, Y; Liu, YL; Ma, ZZ; Wang, JC; Zhang, Q; Zhu, XA, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 7.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "To evaluate the efficacy of sustained-release cis-4-hydroxyproline (CHP), a proline analog that inhibits collagen secretion, on experimental proliferative vitreoretinopathy (PVR) in rabbits." | 7.71 | Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits. ( Honda, Y; Kimura, H; Miyamoto, H; Ogura, Y; Tabata, Y; Yasukawa, T, 2002) |
| "The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF)." | 7.71 | Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. ( Blackburn, B; Chandler, MP; Morita, H; Roth, BA; Sabbah, HN; Stanley, WC; Suzuki, G; Wolff, A, 2002) |
| "We developed a calcium phosphate cement containing arbekacin sulfate and polylactic acid (CPC95AP) and examined its effects on bone strength by injecting the CPC95AP into the femoral medullary cavity in model rats with osteoporosis." | 7.71 | Mechanical properties of the femur after injection of calcium phosphate cement containing arbekacin sulfate and polylactic acid in a rat model of experimental osteoporosis. ( Ishii, Y; Tanaka, A, 2002) |
| "To establish the chemotherapeutic value of a depot drug preparation of isoniazid and pyrazinamide against experimental tuberculosis." | 7.70 | Chemotherapy of tuberculosis in mice using single implants of isoniazid and pyrazinamide. ( Gangadharam, PR; Geeta, N; Hsu, YY; Wise, DL, 1999) |
| "To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone." | 7.70 | Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 7.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 7.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To test the antiviral effect of ganciclovir released from biodegradable polymer microspheres in rabbit eyes inoculated with human cytomegalovirus (HCMV)." | 7.69 | Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus. ( Herrero-Vanrell, R; Refojo, MF; Veloso, AA; Zhu, Q, 1997) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 7.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| "To evaluate the biological effects of aluminum lactate therapy on nodular silicosis, we exposed the tracheal lobe of three groups of sheep containing eight sheep per group to either 11 mg of Al lactate in 100 ml saline (Al group), 100 mg of Minusil-5 in 100 ml saline (Si group), or 100 mg of Minusil-5 in 100 ml saline followed by 11 mg of Al lactate at monthly intervals 4 months after exposure (Si Al-treated group)." | 7.67 | Late aluminum therapy reduces the cellular activities of simple silicosis in the sheep model. ( Bégin, R; Geoffroy, M; Labbé, J; Martel, M; Massé, S; Sébastien, P, 1987) |
| "Metformin was administrated through daily intraperitoneal injection from postnatal day 35 for 4 weeks." | 7.11 | Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice. ( Chang, MY; Chou, LF; Hsu, SH; Hung, CC; Ong, ACM; Tian, YC; Tsai, CY; Yang, CW; Yang, HY, 2022) |
| "Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation." | 5.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 5.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Dimethilhydrazine was used to induce colorectal cancer in mice." | 5.46 | Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. ( Azevedo, V; Bermúdez-Humarán, LG; de Moreno de LeBlanc, A; Del Carmen, S; Langella, P; LeBlanc, JG; Levit, R, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "Conventional treatments of uveitis are not ideal because of the short period of therapeutic efficacy." | 5.40 | Evaluations of therapeutic efficacy of intravitreal injected polylactic-glycolic acid microspheres loaded with triamcinolone acetonide on a rabbit model of uveitis. ( Dai, W; He, B; Li, W; Liu, Y; Zhang, Q, 2014) |
| "The milrinone plasma level was significantly greater in group III than in the other groups (group I, 0 ng/mL; group II, 1." | 5.40 | Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction. ( Al Kindi, H; Nepotchatykh, O; Paul, A; Prakash, S; Schwertani, A; Shum-Tim, D; You, Z, 2014) |
| "Terlipressin (TP) is a vasopressin analogue used to reverse certain shock etiologies in some European countries." | 5.39 | Terlipressin with limited fluid resuscitation in a swine model of hemorrhage. ( Bielawski, A; DeVito, SS; Devlin, JJ; Gutierrez, MA; Henao, J; Johnson, AS; Kotora, J; Littlejohn, LF; Nowak, G, 2013) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 5.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Dermal fibrosis was histologically observed at day 7 after injection and remained present at day 21." | 5.35 | Mouse model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres. ( Ishikawa, O; Negishi, I; Shibusawa, Y; Tabata, Y, 2008) |
| "Streptomycin levels were maintained for 4 days in the plasma and for 7 days in the organs following a single oral administration of PLG nanoparticles." | 5.34 | Nanoparticle-based oral drug delivery system for an injectable antibiotic - streptomycin. Evaluation in a murine tuberculosis model. ( Khuller, GK; Pandey, R, 2007) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 5.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 5.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "In this study, we aim to verify whether swim training can improve lactate metabolism, NAD+ and NADH levels, as well as modify the activity of glycolytic and NADH shuttle enzymes and monocarboxylate transporters (MCTs) in skeletal muscle of amyotrophic lateral sclerosis (ALS) mice." | 4.12 | Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis. ( Antosiewicz, J; Cieminski, K; Dzik, KP; Flis, DJ; Kaczor, JJ; Wieckowski, MR; Ziolkowski, W, 2022) |
| "The authors design an animal model of neonatal sepsis to analyze the treatment of neonatal septic shock with Methylene Blue (MB) in a swine model." | 4.12 | Methylene Blue to Neonatal Septic Shock treatment in neonate pigs ( Albuquerque, AAS; de Castro, RSAP; Evora, PRB; Ferreira, CHF; Gonçalves-Ferri, WA; Oharomari, LK; Silva Lessa, DF, 2022) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 4.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| "Bosutinib as an adjunct therapy to a balanced transfusion strategy reduced resuscitation volume, improved shock reversal, and reduced vascular leak and organ injury in a rat polytrauma model." | 4.02 | Bosutinib reduces endothelial permeability and organ failure in a rat polytrauma transfusion model. ( Aman, J; Botros, L; Hollmann, MW; Juffermans, NP; Kers, J; Kleinveld, DJB; Maas, MAW, 2021) |
| " The present study is aimed at testing the hypothesis that resistant maltodextrin (RM), a soluble dietary fiber produced by starch debranching, alleviated dextran sulfate sodium- (DSS-) induced colitis in mice." | 3.96 | Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels. ( Han, D; Huang, S; Pang, J; Wang, J; Wang, S; Wu, Y; Wu, Z; Zhang, S, 2020) |
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 3.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| "The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA." | 3.88 | Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018) |
| "Therapeutic effects of continuous intravenous infusions of solvent-free low doses of resveratrol on organ injury and systemic consequences resulting from severe hemorrhagic shock in rats were studied." | 3.85 | Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. ( Kirsch, M; Müller, T; Petrat, F, 2017) |
| "Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear." | 3.85 | Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test. ( Chang, TW; Chen, EL; Chen, MH; Chen, TI; Chiang, YC; Jhang, YS; Lai, SC; Lin, CY; Lin, IH; Seenan, V; Shiung, J; Tseng, YW; Tzeng, YJ, 2017) |
| " Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies." | 3.81 | Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015) |
| "To develop thalidomide-loaded poly-lactide-co-glycolide implants and evaluate its in vivo release and biological activity against inflammation and angiogenesis after subcutaneous administration." | 3.81 | Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application. ( Andrade, SP; Batista, LF; da Nova Mussel, W; da Silva, GR; de Souza, PA; Fialho, SL; Pereira, BG; Serakides, R; Silva-Cunha, A, 2015) |
| "This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock." | 3.81 | Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock. ( Dong, Z; Huang, T; Li, Q, 2015) |
| " Inflammation and coagulation are closely associated pathological processes, therefore the potential effects of metformin on key steps in activation of the coagulation system were further investigated in endotoxic hepatitis induced by lipopolysaccharide/D‑galactosamine (LPS/D‑Gal)." | 3.81 | Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis. ( Ai, Q; Ao, JE; Duan, R; Ge, P; Gong, X; Lin, L; Zhang, L, 2015) |
| "The lithium-pilocarpine model of status epilepticus is a well-known animal model of temporal lobe epilepsy." | 3.81 | Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. ( Hillert, MH; Imran, I; Klein, J, 2015) |
| "In this study, ifosfamide-loaded poly (lactic-co-glycolic acid) (PLGA)-dextran polymeric nanoparticles (PD/IFS) was developed and studied its anticancer efficacy against multiple osteosarcoma cancer cells." | 3.81 | Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma. ( Chen, B; Lin, XJ; Wang, LF; Yang, JZ; Zhang, YJ, 2015) |
| " Pathological metabolic shift and subsequent lactic acid production are thought to play an important role in diverse painful states; however, their contribution to inflammation-driven pain is still to be comprehended." | 3.81 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. ( Go, Y; Harris, RA; Jeoung, NH; Jha, MK; Kook, H; Lee, IK; Lee, MG; Park, DH; Song, GJ; Suk, K, 2015) |
| " When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a nonglycolytic phenotype, characterized by a high ratio of oxygen consumption rate over glycolytic rate, negligible lactate production and efficient incorporation of glucose carbon(s) into cellular mass." | 3.80 | Beyond Warburg effect--dual metabolic nature of cancer cells. ( Dai, C; Ding, Z; Hu, D; Hu, X; Ji, B; Luo, Y; Pan, Q; Wu, H; Xie, J, 2014) |
| " In this study, we have evaluated anti-asthmatic efficacy of inhalable montelukast-loaded large porous particulate formulations in ovalbumin-induced rat airway inflammation model that mimics asthma." | 3.80 | Aerosolized montelukast polymeric particles-an alternative to oral montelukast-alleviate symptoms of asthma in a rodent model. ( Ahsan, F; Gupta, N; Patel, B, 2014) |
| "56 g/kg) could upgrade glucose (Glu), total amino acids (T-AA), ATP, Na(+)-K(+) -ATPase, superoxide dismutase (SOD) and catalase (CAT) of brain tissue and degrade lactic acid (LD), malondialdehyde (MDA) and water content of brain tissue in cerebral ischemia rat (P < 0." | 3.80 | [Effect of JTS caps. treating cerebral ischemia on metabolism and antioxidant system in cerebral ischemia rat]. ( Liu, YQ; Wang, RQ; Wang, ZW; Yan, CL; Zhao, B, 2014) |
| "Lactic acidosis occurs in a number of clinical conditions, e." | 3.80 | Lactic acidosis treatment by nanomole level of spermidine in an animal model. ( Mirkhani, H; Sahmeddini, MA; Sattarahmady, N; Sedigh-Ardekani, M, 2014) |
| " The aim of this study was to investigate the effects of hypothyroidism on leucine, mannose, glucose and lactate metabolism in rat cerebellar slices." | 3.79 | Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices. ( da Silveira, CK; de Assis, AM; Farina, M; Longoni, A; Müller, AP; Perry, ML; Souza, DO, 2013) |
| "Flutamide failed to show any benefit to resuscitation in a model of severe injury and was associated with increased acidosis, hemodilution, and liver injury compared with standard crystalloid resuscitation." | 3.79 | Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model. ( Hempel, J; Hoffer, Z; Martin, M; Satterly, SA; Stallings, JD; Wingerd, M, 2013) |
| "Lactic acidosis is a life-threatening complication of hemorrhagic shock." | 3.79 | Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats. ( Bai, XD; Fang, T; Hu, S; Liu, XQ; Wang, HB; Zhong, YX; Zhou, FQ, 2013) |
| " Our purposes were to study the efficacy of tranexamic acid (TXA) and prothrombin complex concentrate (PCC) on a traumatic coagulopathy with a severe native metabolic acidosis and compare the efficacy of PCC versus fresh frozen plasma (FFP) to reverse a dilutional coagulopathy." | 3.79 | The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis. ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013) |
| "PTCA-NC followed by local infusion of sirolimus nanoparticles was safe and efficacious to reduce neointima in this model, and this strategy may be a promising treatment for BMS ISR." | 3.79 | Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis. ( Attizzani, G; Balvedi, JA; Centeno, PR; Kosachenco, BG; Matte, BS; Nascimento, L; Raudales, JC; Yamamoto, GI; Zago, AC; Zago, AJ, 2013) |
| " Compared to normal controls, untreated burned animals showed decreased hemodynamic parameters, increased serum lactic acid, and severe myocardial inflammation." | 3.79 | Shaking stress aggravates burn-induced cardiovascular and renal disturbances in a rabbit model. ( Chen, YS; Hu, JY; Huang, YS; Lei, ZY; Luo, ZH; Ruan, J; Wang, G; Xiao, R; Zhang, BQ; Zhang, JP, 2013) |
| " Our aim was to use magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry to investigate the cerebral effects of the NHE inhibitor, methyl isobutyl amiloride (MIA) given after severe perinatal asphyxia in the piglet." | 3.79 | Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model. ( Bainbridge, A; Cady, E; Chandrasekaran, M; Cheong, J; Faulkner, S; Hristova, M; Iwata, O; Iwata, S; Kapetanakis, A; Kato, T; Raivich, G; Robertson, NJ, 2013) |
| "Under both normovolemia and hypovolemia, glucose levels in rats anesthetized with sevoflurane were significantly higher than those in rats anesthetized with propofol, and insulin levels in rats anesthetized with sevoflurane were significantly lower than those in rats anesthetized with propofol." | 3.78 | The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats. ( Kawamura, G; Kitamura, T; Sato, K; Yamada, Y, 2012) |
| " Reflexes disappeared, and atropine did not induce an increase in heart rate in the brain dead animals." | 3.78 | Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography. ( Andersen, G; Barklin, A; Hvas, CL; Nielsen, TK; Pedersen, M; Sørensen, JC; Tønnesen, E, 2012) |
| "The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates." | 3.78 | Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets. ( Bigam, DL; Cheung, PY; Lee, TF; Liu, JQ; Manouchehri, N; Yao, M, 2012) |
| "Cyclosporine A (CyA) is a useful immunosuppressive agent for steroid-dependent or steroid-refractory ulcerative colitis." | 3.77 | The effective therapy of cyclosporine A with drug delivery system in experimental colitis. ( Fukata, N; Fukui, T; Koyabu, M; Kusuda, T; Matsushita, M; Miyoshi, H; Nishio, A; Okazaki, K; Tabata, Y; Uchida, K, 2011) |
| " We investigated the effect of the LXRα agonist, T0901317, on lung inflammation in a rodent model of hemorrhagic shock." | 3.77 | Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway. ( Denenberg, A; Hake, PW; Lentsch, A; O'Connor, M; Piraino, G; Solan, PD; Zingarelli, B, 2011) |
| "To investigate the therapeutic efficacy and optimal drug dose of an intravitreally implantable voriconazole (VCZ) drug delivery system (DDS) in experimental endophthalmitis of Aspergillus fumigatus." | 3.77 | Intravitreally implantable voriconazole delivery system for experimental fungal endophthalmitis. ( Dong, X; Min, X; Wu, X; Xie, L; Yang, L, 2011) |
| "To investigate the effects of preventive enteral administration of ornithine alpha-ketoglutarate (OKG) in an ischemia-reperfusion rat model." | 3.77 | Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats. ( Garcia, JH; Gonçalves, ES; Guimarães, SB; Prado Neto, AX; Rabelo, CM; Vasconcelos, PR, 2011) |
| "To evaluate the effect of a biodegradable microfilm with sustained release of prednisolone acetate (PA) on postoperative wound healing after experimental glaucoma filtration surgery (GFS)." | 3.77 | Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery. ( Ang, M; Foo, S; Venkatraman, SS; Wong, TT; Yan, P; Zhen, M, 2011) |
| "We tested the hypothesis that reduced caloric intake during endotoxemia, as an experimental model for sepsis, further reduces arginine availability." | 3.76 | Reduced caloric intake during endotoxemia reduces arginine availability and metabolism. ( Bruins, MJ; Deutz, NE; Luiking, YC; Poeze, M, 2010) |
| "Lactic acidemia is one manifestation of the mitochondrial diseases caused by pathogenic mutant mitochondrial DNA (mtDNA)." | 3.76 | Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion. ( Hayashi, J; Nakada, K; Ogasawara, E, 2010) |
| " The effect of GBFY on colonic epithelial proliferation was investigated through loperamide (LPM)-induced constipation in rats." | 3.76 | Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. ( Choi, JH; Jeon, JR, 2010) |
| "The results of our study showed that rats that had been administered oral carvedilol for several days were more resistant to CA induced by airway obstruction, and when CA did occur, were more likely to be resuscitated." | 3.76 | The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. ( Kurita, A; Taniguchi, T; Yamamoto, K, 2010) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 3.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "Polylactic acid (PLA) patch has proper steric configuration, sufficient mechanic strength, and flexibility, to investigate the blocking effect on the intra-discal inflammation after annulus puncture sticked by medical glue so as to seal the pinhole left after annulus puncture." | 3.76 | [A study on blocking effect of polylactic acid patch on intra-discal inflammation after annulus puncture]. ( Feng, G; Gong, Q; Huang, X; Li, T; Liu, H; Liu, L; Liu, X; Shi, R; Song, Y; Zhang, W; Zhao, X, 2010) |
| " Brain tissue was collected following 20 minute cerebral ischemia and 240 minute reperfusion, and used to measure the levels of malondialdehyde (MDA), lactate, water content and the amounts of electrolytes, such as sodium (Na(+)), potassium (K(+)) and calcium (Ca(++))." | 3.75 | Initiation time of post-ischemic hypothermia on the therapeutic effect in cerebral ischemic injury. ( Mei, Y; Sun, S; Tong, E; Zhang, H; Zhang, J; Zhou, M, 2009) |
| "To explore the effect of ethyl pyruvate (EP) and alkaline phosphatase (ALP) on injuries of sepsis and the mechanism involved." | 3.75 | [Effects of ethyl pyruvate on injuries of sepsis in mice]. ( Deng, ZH; Lin, J; Ti, DD; Wang, LH; Xue, H; Yan, GT, 2009) |
| " At a target pressure of 40 mmHg, the initial blood pressure response to oxygen is the same, but it gradually decreases as the animal develops a lactic acidosis." | 3.74 | Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction. ( Atkins, JL; Johnson, KB; Pearce, FJ, 2007) |
| "Drug delivery systems containing gentamicin were studied as a treatment against experimental brucellosis in mice." | 3.74 | Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice. ( Blanco-Prieto, MJ; Campanero, MA; Gamazo, C; Lecaroz, MC; Salman, H, 2007) |
| " Taurine may have been released by the tissues as a protective mechanism against hypoxia-induced inflammation, or in an attempt to maintain osmotic balance." | 3.74 | Taurine as a marker for foetal wellbeing? ( de Boo, HA; Harding, JE, 2007) |
| "Long-term thiamine deficiency has been largely documented, whilst little is known about effects of short-term depletion/repletion periods on thiamine vitamers status." | 3.74 | Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model. ( Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA, 2007) |
| " In this study, hemodynamics, transmural high-energy phosphate (HEP), 2-deoxyglucose-6-phosphate (2-DGP) levels, and myocardial blood flow (MBF) were determined under basal conditions, during dobutamine infusion (DOB: 20 microg x kg(-1) x min(-1) iv), and during coronary stenosis + DOB + 2-deoxyglucose (2-DG) infusion." | 3.74 | Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia. ( Eijgelshoven, MH; Jameel, MN; Mansoor, A; Wang, X; Zhang, J, 2008) |
| "To evaluate the effects of methylene blue (MB) on refractory hemorrhagic shock." | 3.74 | [Effects of methylene blue on refractory hemorrhagic shock]. ( Wang, HL; Wang, Z; Yu, CH; Yu, XZ; Zhu, HD, 2008) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "This study was performed in order to assess the effects of olprinone, a phosphodiesterase III inhibitor, on hepatic oxygen delivery (DO2H), oxygen consumption (VO2H), and mitochondrial oxidation in the liver of a porcine endotoxemia model." | 3.73 | Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia. ( Hashiguchi, T; Isowaki, S; Kakihana, Y; Kaminosono, T; Kanmura, Y; Kawamae, H; Kuniyoshi, T; Nagata, E; Okayama, N; Tahara, M; Tobo, K, 2005) |
| " In this study, we evaluated the effects of intravenously administered poly(lactic acid) nanoparticles encapsulating betamethasone phosphate (BP-PLA NPs) on experimental autoimmune uveoretinitis (EAU) in Lewis rats." | 3.73 | Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate. ( Higaki, M; Ishihara, T; Kitahara, K; Kohno, H; Matsushima, M; Mizushima, Y; Saito, S; Sakai, T, 2006) |
| "We hypothesized that ephedrine and phenylephrine are equal with respect to uterine and placental haemodynamics and fetal acid-base status after exposure to maternal hypoxaemia and hypotension in a chronic sheep model of increased placental vascular resistance (R(UA))." | 3.73 | Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. ( Acharya, G; Alahuhta, S; Erkinaro, T; Kavasmaa, T; Mäkikallio, K; Päkkilä, M; Räsänen, J, 2006) |
| "Levosimendan improved oxygen transport and prevented the development of intramucosal acidosis in this experimental model of endotoxaemia." | 3.73 | Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study. ( Barán, M; Canales, HS; Dubin, A; Edul, VS; Estenssoro, E; Maskin, B; Murias, G; Pozo, MO; Sottile, JP, 2006) |
| " It was demonstrated that the intravitreal injection of the optimized CsA-PLGA-MS decreased significantly the severity of the inflammatory signs, cellular infiltrate, aqueous leukocyte counts, and protein levels in the eyes of experimental rabbits with uveitis, compared to other formulations." | 3.73 | Therapeutic and toxicological evaluations of cyclosporine a microspheres as a treatment vehicle for uveitis in rabbits. ( He, Y; Liu, YL; Ma, ZZ; Wang, JC; Zhang, Q; Zhu, XA, 2006) |
| "Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect." | 3.72 | Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin. ( Jonker, JW; Kato, Y; Kusuhara, H; Schinkel, AH; Sugiyama, Y; Wang, DS, 2003) |
| "To evaluate the efficacy of sustained-release cis-4-hydroxyproline (CHP), a proline analog that inhibits collagen secretion, on experimental proliferative vitreoretinopathy (PVR) in rabbits." | 3.71 | Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits. ( Honda, Y; Kimura, H; Miyamoto, H; Ogura, Y; Tabata, Y; Yasukawa, T, 2002) |
| "The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MVO2) and thus improves LV mechanical efficiency in dogs with heart failure (HF)." | 3.71 | Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure. ( Blackburn, B; Chandler, MP; Morita, H; Roth, BA; Sabbah, HN; Stanley, WC; Suzuki, G; Wolff, A, 2002) |
| " Hypoxia induced an immediate and significant elevation in the intraperitoneal lactate/pyruvate ratio to 446+/-137% of the baseline values, and glycerol subsequently increased during reoxygenation to 389+/-109%." | 3.71 | Intraperitoneal microdialysis for detection of splanchnic metabolic disorders. ( Bahlmann, L; Bruch, HP; Gliemroth, J; Heringlake, M; Klaus, S, 2002) |
| " We hypothesize that these abnormalities may limit cardiac resuscitation from ventricular fibrillation (VF) and investigated whether NHE-1 inhibition with the benzoylguanidine derivative cariporide could improve resuscitability, postresuscitation myocardial function, and short-term survival in isolated heart and intact rat models of VF." | 3.71 | Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide. ( Ayoub, IM; Gazmuri, RJ; Hoffner, E; Kolarova, JD, 2001) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "We developed a calcium phosphate cement containing arbekacin sulfate and polylactic acid (CPC95AP) and examined its effects on bone strength by injecting the CPC95AP into the femoral medullary cavity in model rats with osteoporosis." | 3.71 | Mechanical properties of the femur after injection of calcium phosphate cement containing arbekacin sulfate and polylactic acid in a rat model of experimental osteoporosis. ( Ishii, Y; Tanaka, A, 2002) |
| " The purpose of this investigation was to develop and characterize a biodegradable, implantable delivery system containing ciprofloxacin hydrochloride (HCl) for the localized treatment of osteomyelitis and to study the extent of drug penetration from the site of implantation into the bone." | 3.70 | In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants. ( Ramchandani, M; Robinson, D, 1998) |
| "To establish the chemotherapeutic value of a depot drug preparation of isoniazid and pyrazinamide against experimental tuberculosis." | 3.70 | Chemotherapy of tuberculosis in mice using single implants of isoniazid and pyrazinamide. ( Gangadharam, PR; Geeta, N; Hsu, YY; Wise, DL, 1999) |
| " Ischemia did not modify the effects of fluids or dobutamine on systemic hemodynamics and oxygen transport." | 3.70 | Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion. ( Alhava, E; Hartikainen, J; Heino, A; Koski, EM; Merasto, ME; Takala, J; Tenhunen, J, 2000) |
| "To compare the effects of a 12 h continuous infusion of iloprost, a stable prostacyclin analogue, on hepatic blood flow (Qliv), O2 exchange, and energy metabolism during a 24 h hyperdynamic, porcine endotoxemia with volume resuscitation alone." | 3.70 | Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost. ( Altherr, J; Brinkmann, A; Georgieff, M; Jauch, KW; Matejovic, M; Radermacher, P; Träger, K; Vlatten, A; Vogt, J; Wachter, U; Zülke, C, 2000) |
| "We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction." | 3.70 | N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction. ( Arai, M; Chen, XH; Fujiwara, H; Fujiwara, T; Hashimoto, K; Minatoguchi, S; Nishida, Y; Takemura, G; Uno, Y; Wang, N, 2000) |
| " Parallel to these changes, systemic lactic acidosis developed." | 3.69 | Detection of liver ischemia using microdialysis during experimental peritonitis in pigs. ( Haglund, U; Hillered, L; Rasmussen, I; Ungerstedt, U, 1994) |
| "The influence of pentoxifylline (PTX) on mortality and some important mediators was studied in a model of cecal perforation with fulminant intra-abdominal sepsis in rats." | 3.69 | Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats. ( Ekstrøm, P; Giercksky, KE; Lundblad, R, 1995) |
| "To test the antiviral effect of ganciclovir released from biodegradable polymer microspheres in rabbit eyes inoculated with human cytomegalovirus (HCMV)." | 3.69 | Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus. ( Herrero-Vanrell, R; Refojo, MF; Veloso, AA; Zhu, Q, 1997) |
| "The effects of dichloroacetate (DCA) on brain lactate, intracellular pH (pHi), phosphocreatine (PCr), and ATP during 60 min of complete cerebral ischemia and 2 h of reperfusion were investigated in rats by in vivo 1H and 31P magnetic resonance spectroscopy; brain lactate, water content, cations, and amino acids were measured in vitro after reperfusion." | 3.68 | Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. ( Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR, 1992) |
| "In this acute, nonresuscitated, canine hemorrhagic shock model, pentoxifylline did not act as a vasodilator, or have any significant effect on HR, cardiac output, oxygen transport, or lactic acidosis." | 3.68 | Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock. ( Amin, D; Benjamin, E; Fischer, E; Iberti, TJ; Jacobs, E; Klapholtz, A; Oropello, JM, 1991) |
| "To evaluate the biological effects of aluminum lactate therapy on nodular silicosis, we exposed the tracheal lobe of three groups of sheep containing eight sheep per group to either 11 mg of Al lactate in 100 ml saline (Al group), 100 mg of Minusil-5 in 100 ml saline (Si group), or 100 mg of Minusil-5 in 100 ml saline followed by 11 mg of Al lactate at monthly intervals 4 months after exposure (Si Al-treated group)." | 3.67 | Late aluminum therapy reduces the cellular activities of simple silicosis in the sheep model. ( Bégin, R; Geoffroy, M; Labbé, J; Martel, M; Massé, S; Sébastien, P, 1987) |
| "Metformin was administrated through daily intraperitoneal injection from postnatal day 35 for 4 weeks." | 3.11 | Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice. ( Chang, MY; Chou, LF; Hsu, SH; Hung, CC; Ong, ACM; Tian, YC; Tsai, CY; Yang, CW; Yang, HY, 2022) |
| "Group IV mice had the least acute lung injury, with no detectable interleukin-6 response." | 2.70 | Improved resuscitation minimizes respiratory dysfunction and blunts interleukin-6 and nuclear factor-kappa B activation after traumatic hemorrhage. ( Claridge, JA; Schulman, AM; Young, JS, 2002) |
| "Acetaminophen (APAP) is a commonly used and effective analgesic/antipyretic agent and relatively safe drug even in long-term treatment." | 2.52 | [Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity]. ( Kobayashi, A; Kondo, K; Sugai, S, 2015) |
| " The previously unstudied dose-response also was evaluated in our study." | 2.38 | Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. ( Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "Twelve pigs were subjected to hemorrhagic shock and 45 min of REBOA." | 1.91 | Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock. ( Ewer, N; Ford, R; Hoareau, GL; Johnson, MA; Neff, LP; Patel, N; Van Brocklin, MW; Vapniarsky, N; Williams, TK; Youngquist, ST, 2023) |
| "Stroke is the main cause of acquired disability in adults." | 1.91 | Pre-stroke exercise does not reduce atrophy in healthy young adult mice. ( Brox, C; Christiansen, CL; Doosje, HL; Geiseler, SJ; Liesz, A; Morland, C; Nguyen, TD; Phan, KD; Tartanoglu, C, 2023) |
| "In a mouse model of cardiac arrest, 100 mg/kg NAM administered IV immediately after cardiopulmonary resuscitation resulted in 100% survival at 4 h as compared to 50% in the saline group." | 1.91 | Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest. ( Gasior, FM; Justice, CN; Lee, C; Li, J; Lin, S; O'Donnell, JM; Vanden Hoek, TL; Wang, H; Zhu, X, 2023) |
| "Ischemia was induced by sequential arterial and venous occlusions of 45-minute duration, with two-hour reperfusion after each occlusion." | 1.72 | Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model. ( Haugaa, H; Horneland, R; Hødnebø, S; Kjøsen, G; Pischke, SE; Rydenfelt, K; Strand-Amundsen, R; Tønnessen, TI, 2022) |
| "Tamoxifen is an effective breast cancer therapy in postmenopausal women." | 1.72 | Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model. ( Bellozi, PMQ; Itinose, AM; Koerich, S; Marek, CB; Sandrini, F; Schneider, SCS; Silva, FC, 2022) |
| "Forced miR-342-3p expression in hepatoma cells showed significantly decreased cell proliferation, migration, and colony formation." | 1.62 | MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma. ( Balakrishnan, A; Daon, J; Goga, A; Hu, Q; Komoll, RM; Manns, MP; Olarewaju, O; Ott, M; Qin, R; Sharma, AD; Tsay, HC; von Döhlen, L; Xie, Y; Yuan, Q, 2021) |
| "Psoriasis is a chronic, inflammatory skin disease." | 1.62 | Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice. ( Chang, L; Fujita, Y; Hashimoto, K; Hashimoto, Y; Ishima, T; Matsue, H; Shinno-Hashimoto, H; Wei, Y, 2021) |
| "Endometriosis is a chronic hormonal inflammatory disease characterized by the presence of endometrial tissue outside the uterus." | 1.62 | HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression. ( Ren, C; Wang, Y; Xiu, J; Yang, T; Yu, Z, 2021) |
| "In a rat model of multiple injuries and hemorrhagic shock, early administration of EVs significantly reduced the elevation of lactate and creatinine and did not significantly enhance coagulopathy in rats with acute traumatic coagulopathy." | 1.62 | Extracellular vesicles derived from cardiosphere-derived cells as a potential antishock therapeutic. ( Atai, NA; Bynum, JA; Cap, AP; Chance, TC; Garcia-Marcano, J; Gould, SJ; Keesee, JD; Liu, B; Marban, LS; Moseley, JJ; Peck, KA; R-Borlado, L; Rathbone, CR; Salgado, CL; Wu, X, 2021) |
| "Hypovolemia was induced and maintained for 20 min by removal of 50% of the total blood volume; thereafter, the animals were retransfused." | 1.56 | Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model. ( Bischoff, SJ; Irintchev, A; Lehmann, T; Lemke, C; Nistor, M; Schiffner, R; Schmidt, M, 2020) |
| "Emodin was used as a potential therapeutic for ICH." | 1.56 | Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches. ( Cai, E; Lin, L; Liu, Y; Nie, B; Tian, Q; Wang, J; Xu, F; Yang, S; Zeng, P, 2020) |
| "Lactic acid levels were high immediately after ROSC in both groups, but were significantly lower in the 20 rpm group at 30 (3." | 1.56 | Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model. ( Arias, P; Domenech, B; Fernández, SN; Horcajo, D; López, J; López-Herce, J; Nocete, JP; Zamora, L, 2020) |
| "SLC1A3 was found to be overexpressed in gastric cancer, and this overexpression was associated with poor prognosis." | 1.56 | SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway. ( Awaleh Moumin, F; Cai, J; Chen, J; Chen, X; Jia, L; Xu, L, 2020) |
| "However, disc degeneration was found and gradually worsened in AL group after surgery." | 1.51 | Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion. ( Kurra, S; Niu, J; Shi, J; Wang, Z; Yang, H; Zhou, X, 2019) |
| "Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC)." | 1.51 | ( Cao, G; Li, J; Li, Z; Shen, H; Xie, P; Yue, Z; Zang, T; Zhang, S; Zhu, Y, 2019) |
| "Curcumin is a natural product with several anti-Alzheimer's disease (AD) neuroprotective properties." | 1.51 | Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease. ( Gan, SW; Huang, J; Huang, SQ; Jiang, XL; Li, Y; Lu, WT; Qiu, GP; Sun, SQ; Xu, J; Xu, SY; Zhuo, F, 2019) |
| "Treatment with carvedilol restored VMH lactate levels and improved the adrenaline (epinephrine) responses." | 1.51 | Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats. ( Chan, O; Farhat, R; Fisher, SJ; Knight, N; Sejling, AS; Su, G, 2019) |
| "Hemorrhagic shock was induced for 30 minutes while a leg compression device was applied." | 1.51 | Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury. ( Beyer, CA; Grayson, JK; Hoareau, GL; Kashtan, H; Ross, JD; Stewart, IJ; Walker, L; Wilson, C; Wishy, A, 2019) |
| "Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated." | 1.51 | Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification. ( Brown, AM; Evans, RD; Ransom, BR; Rich, LR; Smith, PA, 2019) |
| "Sepsis is a systemic inflammatory response syndrome resulting from infection." | 1.51 | MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway. ( Bai, YP; Li, J; Li, TM; Liu, L; Liu, XR; Tang, N; Wang, XB, 2019) |
| "Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction." | 1.51 | Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. ( Bauer, M; Bonios, MJ; de Lucia, C; Drosatos, K; Hoffman, M; Koch, WJ; Kyriazis, ID; Lucchese, AM; Piedepalumbo, M; Schulze, PC, 2019) |
| "Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation." | 1.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 1.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments." | 1.48 | Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord. ( Alizadeh, A; Henrie, R; Karimi-Abdolrezaee, S; Kataria, H; Saboktakin Rizi, S; Santhosh, KT; Shahriary, GM; Thliveris, JA, 2018) |
| " The present study investigated the impact of IAI combined with IAH on the intestinal mucosal barrier in a rabbit model." | 1.48 | Intra-abdominal infection combined with intra-abdominal hypertension aggravates the intestinal mucosal barrier dysfunction. ( Li, J; Li, Y; Ren, J; Wu, X, 2018) |
| "Bupivacaine is a commonly used local anesthetic in postoperative pain management." | 1.48 | Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. ( Dai, F; Hurwitz, O; LaMotte, RH; Ma, C; Shimada, SG; Tian, D; Wang, T; Zhou, J, 2018) |
| "Lactic acid concentration was measured in the RPE-choroid region." | 1.48 | Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization. ( Che, JH; Cho, CS; Chung, H; Jung, D; Kim, JH; Lee, K; Na, YR; Park, JH; Park, SW; Quan, H; Seok, SH; Song, J, 2018) |
| "Changes in vascular reactivity during endotoxic shock are organ-specific." | 1.48 | Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model. ( Chen, W; Li, T; Liu, LM; Zhang, ZS, 2018) |
| "Three breast cancer cell lines and immunocompetent and immunodeficient mice were used to evaluate the therapeutic effects of Rp plus ω-3 PUFA treatment." | 1.48 | Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death. ( Chen, W; Chen, YQ; Feng, N; He, Z; Jiang, X; Lin, G; Tong, Y; Wang, S; Yang, Q; Zhu, S, 2018) |
| "Status epilepticus was evoked in half of the sedentary and trained rats by a repetitive intraperitoneal injection of KA in low subconvulsive doses." | 1.46 | Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus. ( Andreev, GG; Georgiev, NG; Georgieva, KN; Hadjieva, MS; Shishmanova-Doseva, MS; Tchekalarova, JD; Terzieva, DD, 2017) |
| "Further, neonatal hypothyroidism affected germ cell proliferation with decreased expression of proliferating cell nuclear antigen (PCNA) and Cx43." | 1.46 | Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. ( Sarkar, D; Singh, SK, 2017) |
| "The rabbit annular defect model of disc degeneration appears suitable to investigate the effects of nerve ingrowth in relation to pain generation." | 1.46 | Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration. ( Fan, S; Wang, W; Wang, Z; Xin, L; Xu, W; Yu, F; Yu, L, 2017) |
| "The rats underwent 5 min of untreated asphyxial cardiac arrest and were resuscitated by ECLS for 30 min." | 1.46 | Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model. ( Chang, RW; Chen, YS; Luo, CM; Wang, CH; Yu, HY, 2017) |
| "We utilized a porcine cardiac arrest model to compare early sequential hypothermia (ESH) with delayed hypothermia (DH) and no hypothermia (NH) to investigate the different effects on cerebral function after resuscitation." | 1.46 | Comparison of early sequential hypothermia and delayed hypothermia on neurological function after resuscitation in a swine model. ( Li, CS; Li, J; Li, JB; Li, ZH; Wu, JY; Yuan, W; Zhao, YZ, 2017) |
| "During the 8th week, two wounds were created in the dorsum and collected 10 days later." | 1.46 | Exercise prior to, but not concomitant with, stress reverses stress-induced delayed skin wound healing. ( Martins, RL; Monte-Alto-Costa, A; Romana-Souza, B; Saguie, BO, 2017) |
| "Epilepsy is a chronic neurological disorder that affects approximately 50 million people worldwide." | 1.46 | Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. ( Becker, HM; Deitmer, JW; Forero-Quintero, LS, 2017) |
| "The therapy of inflammatory bowel diseases is still rather inefficient, and about 80% of patients require surgery at some stage." | 1.46 | Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model. ( Carreras, JJ; Draheim, C; Garrigues, TM; Giner, E; Giner, R; Hansen, S; Lehr, CM; Melero, A; Peris, JE; Recio, MC; Talens-Visconti, R, 2017) |
| "Colitis was induced on Day 35, the animals were sacrificed on Day 37." | 1.46 | Preparation and investigation of P28GST-loaded PLGA microparticles for immunomodulation of experimental colitis. ( Capron, M; Delbeke, M; Dendooven, A; Driss, V; Flament, MP; Karrout, Y; Priemel, PA; Siepmann, J; Thi, THH, 2017) |
| " This work marks the first report for controlled release of rhbFGF in combination with metal Mg, and suggests potential therapeutic usefulness of Mg-PLGA-rhbFGF for tissue ischemia." | 1.46 | A pro-angiogenic degradable Mg-poly(lactic-co-glycolic acid) implant combined with rhbFGF in a rat limb ischemia model. ( Bao, H; Liu, T; Lv, F, 2017) |
| "A rabbit hemorrhagic shock model was developed by bloodletting from the carotid artery." | 1.46 | Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock. ( Qiu, W; Shao, Z; Sun, J; Sun, W; Xu, H, 2017) |
| "Dimethilhydrazine was used to induce colorectal cancer in mice." | 1.46 | Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. ( Azevedo, V; Bermúdez-Humarán, LG; de Moreno de LeBlanc, A; Del Carmen, S; Langella, P; LeBlanc, JG; Levit, R, 2017) |
| "Among the types of vehicles for cancer vaccines, nanoparticles (NPs) are easier to produce with better scalability." | 1.46 | Nanotechnology-Based Cancer Vaccine. ( Alshamsan, A, 2017) |
| " In the low dosage range (<100μg), CAMP factor had no obvious toxicity in mice." | 1.46 | Development of a single-dose recombinant CAMP factor entrapping poly(lactide-co-glycolide) microspheres-based vaccine against Streptococcus agalactiae. ( Barkema, HW; Chen, L; De Buck, J; Han, B; Kastelic, JP; Liu, G; Shahid, M; Szenci, O; Yin, J, 2017) |
| " Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice." | 1.46 | Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice. ( Abe, K; Egashira, K; Fukuda, K; Kamei, A; Kinjo, A; Kondo, T; Kozuka, C; Masuzaki, H; Morinaga, H; Nakano, K; Shimizu-Okabe, C; Takayama, C; Yasuoka, A, 2017) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| " Whereas free thioridazine was highly toxic in both cells and zebrafish embryos, after encapsulation in nanoparticles no toxicity was detected." | 1.43 | Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish. ( Anes, E; Bogoeva, V; Fenaroli, F; Griffiths, G; Hildahl, J; Kalluru, R; Pires, D; Speth, M; Vibe, CB; Wilson, SR, 2016) |
| " Intravenously dosed tissue plasminogen activator (tPA) has been shown to rapidly lyse ILTs in acute stroke and myocardial infarctions." | 1.43 | Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix. ( Ramamurthi, A; Sivaraman, B; Sylvester, A, 2016) |
| "The percent stenosis degree of RPM-PLGA NPs group was significantly lower than that of the other three groups respectively (all P< 0." | 1.43 | [Efficacy and mechanism of local delivery of rapamycin and rapamycin-loaded poly(lactic-co-glycolic) acid nanoparticles on coronary restenosis of injury-stenosis model of minipigs]. ( Chen, LF; Cui, YL; Huang, CL; Miao, LF; She, MP; Song, CX; Yang, J; Yin, YP; Zeng, Y; Zhang, H; Zhu, WL, 2016) |
| "Left ventricular remodeling was ameliorated 28 days after IR, but the treatment did not affect inflammatory monocyte recruitment to the IR heart." | 1.43 | Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening. ( Egashira, K; Funamoto, D; Ikeda, G; Ishikita, A; Matoba, T; Nagaoka, K; Nakano, K; Nakano, Y; Sunagawa, K, 2016) |
| "Lactic acidosis was fully corrected and survival increased in group PR (50." | 1.43 | Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. ( Bai, XD; Guo, SJ; Hu, S; Hu, XH; Li, ZY; Liu, R; Wang, SM; Zhou, FQ, 2016) |
| "Treatments to reverse peanut allergy remain elusive." | 1.43 | Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. ( Caplan, MJ; Fahmy, TM; Li, XM; Sampson, HA; Siefert, A; Srivastava, KD, 2016) |
| "Intriguingly, sleep fragmentation, despite normal total sleep duration, has a similar cognitive impact, and in this paper we ask the question of whether it may also impair brain energy metabolism." | 1.43 | Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure. ( Baud, MO; Magistretti, PJ; Nguyen, A; Parafita, J; Petit, JM, 2016) |
| "Potassium cyanide (KCN) is an inhibitor of cytochrome C oxidase causing rapid death due to hypoxia." | 1.43 | Characterization of a Mouse Model of Oral Potassium Cyanide Intoxication. ( Gibbs, ST; Hong, P; Kobs, CL; Matthews, CM; Patton, KM; Sabourin, CL; Sabourin, PJ; Wakayama, EJ, 2016) |
| "Cerebral metabolic alterations during cardiac arrest, cardiopulmonary resuscitation (CPR) and extracorporeal cardiopulmonary life support (ECLS) are poorly explored." | 1.43 | Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial. ( Ettl, F; Herkner, H; Högler, S; Hosmann, A; Janata, A; Laggner, AN; Magnet, IA; Scherer, T; Schober, A; Sterz, F; Testori, C; Warenits, AM; Weihs, W; Zeitlinger, M, 2016) |
| "Cardiovascular protein therapeutics such as neuregulin (NRG1) and acidic-fibroblast growth factor (FGF1) requires new formulation strategies that allow for sustained bioavailability of the drug in the infarcted myocardium." | 1.43 | Catheter-based Intramyocardial Injection of FGF1 or NRG1-loaded MPs Improves Cardiac Function in a Preclinical Model of Ischemia-Reperfusion. ( Abizanda, G; Blanco-Prieto, MJ; de Yebenes, MG; Garbayo, E; Gavira, JJ; Lana, H; Pelacho, B; Prosper, F, 2016) |
| "Atorvastatin treatment resulted in a rise in both CK (2X) and myoglobin (6X) level with graded degrees of muscle necrosis." | 1.43 | Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model. ( Abdallah, D; El-Ganainy, SO; El-Khatib, AS; El-Mallah, A; Khattab, MM; Mohy El-Din, MM, 2016) |
| "McArdle disease is due to an absence of the enzyme muscle glycogen phosphorylase and results in significant physical impairment in humans." | 1.42 | Investigating sodium valproate as a treatment for McArdle disease in sheep. ( Creed, KE; Dunton, E; Howell, JM; Quinlivan, R; Sewry, C, 2015) |
| " In the present study, neuroprotective properties of creatylglycine ethyl ester fumarate (CrGEt) in rats with focal cerebral ischemia were explored in a wide dosage range (30-280 mg/kg, intravenous and intragastric)." | 1.42 | Neuroprotective activity of creatylglycine ethyl ester fumarate. ( Barygin, OI; Isaeva, AV; Korzhevskii, DE; Morozov, VA; Portsel, MN; Tihonov, DB; Veselkina, OS; Vlasov, TD, 2015) |
| "BxPC-3 pancreatic cancer cells were cultured under hypoxic conditions and treated with or without the nanoparticles." | 1.42 | PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo. ( Fang, W; Li, K; Li, L; Pan, X; Sun, Y; Zhao, Z; Zhu, Q; Zhu, Y; Zuo, J, 2015) |
| "Systemic arterial hypertension has been previously suggested to develop as a compensatory condition when central nervous perfusion/oxygenation is compromised." | 1.42 | Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. ( Ang, R; Gourine, AV; Hosford, PS; Karagiannis, A; Kasparov, S; Kasymov, V; Machhada, A; Marina, N; Mosienko, V; Paton, JF; Teschemacher, AG; Vihko, P, 2015) |
| "For other groups, severe sepsis was induced by CLP." | 1.42 | Shenfu injection alleviates intestine epithelial damage in septic rats. ( Chen, Z; Huang, L; Jiang, R; Lei, S; Wang, L; Wu, Y; Xia, G; Xing, X; Zhi, Y; Zhu, M, 2015) |
| "Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE)." | 1.42 | Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats. ( Lou, H; Shi, H; Sun, D; Xue, A; Zhang, B; Zhang, X, 2015) |
| "Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury." | 1.42 | Time- and dose-dependent severity of lung injury in a rat model of sepsis. ( Azamfirei, L; Cioc, AD; Copotoiu, SM; Cotoi, OS; Fodor, P; Fodor, RŞ; Georgescu, AM; Grigorescu, BL, 2015) |
| "Conventional treatments of uveitis are not ideal because of the short period of therapeutic efficacy." | 1.40 | Evaluations of therapeutic efficacy of intravitreal injected polylactic-glycolic acid microspheres loaded with triamcinolone acetonide on a rabbit model of uveitis. ( Dai, W; He, B; Li, W; Liu, Y; Zhang, Q, 2014) |
| "Pain is often associated with depression of behavior and mood, and relief of pain-related depression is a common goal of treatment." | 1.40 | Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. ( Banks, ML; Bowers, MS; Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Onvani, S; Rice, KC, 2014) |
| "Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events." | 1.40 | Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014) |
| "Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM)." | 1.40 | Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage. ( Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC, 2014) |
| " The osteogenic effect of simvastatin-loaded bone cement was in a critical sized defect in vivo to test the hypothesis the biologic response would be different depending on the dosage of simvastatin applied to bone cement." | 1.40 | The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria. ( Coelho, PG; Galli, S; Ichikawa, T; Jimbo, R; Kozai, Y; Naito, Y; Ozeki, T; Tagami, T; Terukina, T; Vandeweghe, S, 2014) |
| "When wild-type KISS1 metastasis suppressor is expressed, aerobic glycolysis decreases and oxidative phosphorylation predominates." | 1.40 | Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis. ( Ballinger, SW; Beck, BH; Denning, WL; Dhar, A; Diers, AR; Feeley, KP; Iwakuma, T; Landar, A; Liu, W; Nash, KT; Pounds, KM; Vaidya, KS; Welch, DR, 2014) |
| "An acetic acid (AA)-induced ulcerative colitis rat model was applied in the study." | 1.40 | The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. ( Jia, W; Lu, H; Ma, C; Qiu, M; Sun, W; Wu, H; Xin, X; Yang, Y; Zhao, A; Zhao, L; Zou, H, 2014) |
| "Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties." | 1.40 | pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease. ( Beloqui, A; Coco, R; des Rieux, A; Memvanga, PB; Préat, V; Ucakar, B, 2014) |
| "Intestinal ischemia-reperfusion injury is one of the main factors leading to multiple organ failure after resuscitation of prolonged hemorrhagic shock; however, the current conventional fluid resuscitation still cannot effectively reduce intestinal injury caused by prolonged hemorrhagic shock." | 1.40 | Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model. ( Chen, J; Jia, W; Luo, L; Xiao, J; Xiao, Y; Zhao, L, 2014) |
| "In our hypodynamic model of endotoxic shock, infusion of hypertonic sodium lactate improves hemodynamic and microvascular reactivity with a negative fluid balance and a better oxygenation." | 1.40 | Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock. ( Duburcq, T; Favory, R; Gmyr, V; Hubert, T; Jourdain, M; Maboudou, P; Mangalaboyi, J; Mathieu, D; Pattou, F; Quintane, L, 2014) |
| "The milrinone plasma level was significantly greater in group III than in the other groups (group I, 0 ng/mL; group II, 1." | 1.40 | Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction. ( Al Kindi, H; Nepotchatykh, O; Paul, A; Prakash, S; Schwertani, A; Shum-Tim, D; You, Z, 2014) |
| "Ischemic myalgia is a unique type of muscle pain in the patient population." | 1.40 | Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury. ( Hudgins, RC; Jankowski, MP; Queme, LF; Ross, JL; Shank, AT, 2014) |
| "Paclitaxel was encapsulated in particles coated with a layer of polydopamine and a subsequent layer of poly(ethylene glycol) (PEG)." | 1.40 | Dual-layer surface coating of PLGA-based nanoparticles provides slow-release drug delivery to achieve metronomic therapy in a paclitaxel-resistant murine ovarian cancer model. ( Amoozgar, Z; Brandstoetter, T; Goldberg, MS; Wallis, SS; Wang, L; Wilson, EM, 2014) |
| "D-Allose was intravenously injected before and after ischemia (200 mg/kg)." | 1.40 | The effects of D-allose on transient ischemic neuronal death and analysis of its mechanism. ( Itano, T; Keep, RF; Liu, Y; Nakamura, T; Shinomiya, A; Tamiya, T; Tokuda, M; Toyoshima, T, 2014) |
| " Polymeric porous particles of PGE1 produced the same effects at a reduced dosing frequency compared to plain PGE1 and caused minimal off-target effects on systemic hemodynamics." | 1.39 | Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. ( Ahsan, F; Gupta, N; Gupta, V; Komatsu, M; McMurtry, IF; Mehvar, R; Nozik-Grayck, E; Oka, M; Shaik, IH, 2013) |
| "Cardiac functional deterioration in dilated cardiomyopathy (DCM) is known to be reversed by intramyocardial up-regulation of multiple cardioprotective factors, whereas a prostacyclin analog, ONO1301, has been shown to paracrinally activate interstitial cells to release a variety of protective factors." | 1.39 | A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure. ( Daimon, T; Fukushima, S; Kawaguchi, N; Matsuura, N; Miyagawa, S; Nakatani, S; Okita, Y; Saito, A; Sakai, Y; Sawa, Y; Shiozaki, M; Shirasaka, T, 2013) |
| "Terlipressin (TP) is a vasopressin analogue used to reverse certain shock etiologies in some European countries." | 1.39 | Terlipressin with limited fluid resuscitation in a swine model of hemorrhage. ( Bielawski, A; DeVito, SS; Devlin, JJ; Gutierrez, MA; Henao, J; Johnson, AS; Kotora, J; Littlejohn, LF; Nowak, G, 2013) |
| "Mice were subjected to cardiac hypertrophy secondary to pressure-overload as a result of an abdominal aortic constriction (AAC)." | 1.39 | Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. ( Jaswal, JS; Lopaschuk, GD; Sankaralingam, S; Ussher, JR; Wagg, C; Zaugg, M; Zhang, L, 2013) |
| "In two chemically induced seizure models, mice with reduced tau protein had less severe seizures than control mice." | 1.39 | Antisense reduction of tau in adult mice protects against seizures. ( Bennett, CF; Chen, G; Cirrito, JR; DeVos, SL; Goncharoff, DK; Holtzman, DM; Kebodeaux, CS; Maloney, SE; Miller, TM; Rigo, F; Schuler, DR; Stewart, FR; Wozniak, DF; Yamada, K, 2013) |
| "This study showed that breast cancer cells tolerate and use lactate at clinically relevant concentrations in vitro (± glucose) and in vivo." | 1.39 | Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. ( Chi, JT; Dewhirst, MW; Kennedy, KM; Landon, CD; Pizzo, S; Ribeiro, A; Richardson, R; Scarbrough, PM; Schroeder, T; Sonveaux, P; Yuan, H, 2013) |
| " However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin." | 1.39 | Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013) |
| "Titanium anchors were implanted into the right tibia, followed by biomechanical tensile strength tests." | 1.39 | In vivo investigation of calcium phosphate coatings on Ti6-Al-4V alloy substrates using lactic acid - sodium lactate buffered synthetic body fluid. ( Aydin, I; Ceçen, B; Havitçioğlu, H; Pasinli, A; Yildiz, H; Yüksel, M, 2013) |
| " Therefore, to stimulate not only the soft tissues, but also the hard tissues, in this study EMD is combined with an injectable calcium phosphate cement (CaP; bone graft material)." | 1.39 | Regeneration of the periodontium using enamel matrix derivative in combination with an injectable bone cement. ( Bronckers, AL; Jansen, JA; Meijer, GJ; Oortgiesen, DA; Walboomers, XF, 2013) |
| "The rabbits were randomly divided into 3 groups: group A without any treatment, group B with single treatment of stilamin, and group C with treatment of saizen combined with stilamin." | 1.39 | Protective effects of saizen in combination with stilamin on intestinal mucosa of a rabbit model of severe acute pancreatitis. ( Li, B; Liu, H; Lu, Y; Xu, H; Yang, M; Yu, Y, 2013) |
| "Icaritin was homogenized into poly lactic-co-glycolic acid/tricalcium phosphate (PLGA/TCP) to form an icaritin-releasing porous composite scaffold (PLGA/TCP/icaritin) by fine-spinning technology." | 1.39 | Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair. ( Chen, SH; Fung, KP; He, K; Leng, Y; Leung, KS; Qin, L; Wang, XH; Wang, XL; Xie, XH; Yao, D; Yao, XS; Zhang, G, 2013) |
| "Glycine has been shown to participate in protection from hypoxia/reoxygenation injury." | 1.39 | Effects of glycine supplementation on myocardial damage and cardiac function after severe burn. ( Liang, GP; Lv, SJ; Peng, X; Wan, QX; Wang, L; Yan, H; Zhang, Y, 2013) |
| "Pain is associated with stimulation of some behaviors (eg, withdrawal reflexes) but depression of many other behaviors (eg, feeding, locomotion, positively reinforced operant behavior)." | 1.39 | Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats. ( Carroll, FI; Negus, SS; Rosenberg, MB, 2013) |
| "Cerebral infarction was induced by the injection of microspheres (MS) into the right internal carotid artery." | 1.38 | Changes in the lactate threshold during treadmill exercise after microsphere-induced infarction in rats. ( Himi, N; Koga, T; Kuniyasu, K; Takahashi, H, 2012) |
| "Colitis was induced by rectal instillation of trinitrobenzen sulfonic acid to male Wistar rats." | 1.38 | Biochemical and pathological evidences on the benefit of a new biodegradable nanoparticles of probiotic extract in murine colitis. ( Abdolghaffari, AH; Abdollahi, M; Atyabi, F; Baeeri, M; Baghaei, A; Dinarvand, R; Fazeli, MR; Jamalifar, H; Mahbod, M; Mahdaviani, P; Mohammadirad, A; Saadatzadeh, A, 2012) |
| " The purpose of this study was to investigate a novel treatment for TB meant to improve patient compliance by reducing drug dosage frequency." | 1.38 | Antimycobacterial activity of 2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan, entrapped in polymeric microparticles. ( Barata, LE; Bentley, MV; de Souza, AO; Minarini, PR; Silva, CL; Soares, EG, 2012) |
| "Severe acute pancreatitis was induced in the first 2 groups by injecting 5% sodium taurocholate into the pancreatic duct, and the investigation period was 12 hours." | 1.38 | Beneficial effect of hypertonic saline resuscitation in a porcine model of severe acute pancreatitis. ( Ding, WW; Ke, L; Li, JS; Li, N; Li, WQ; Ni, HB; Sun, JK; Tong, ZH, 2012) |
| " Thus, long-term administration of Shh is a potential valuable therapeutic intervention for SCI." | 1.38 | The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice. ( Banerjee, A; Charniga, C; Goderie, SK; Gooch, MR; Gracey, KD; Kane, RS; Lederman, P; Lowry, N; Punyani, S; Silver, J; Stern, JH; Temple, S, 2012) |
| "Intestinal ischemia is difficult to diagnose noninvasively." | 1.38 | Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons. ( Bahrami, S; Hölzenbein, T; Khadem, A; Kröpfl, A; Redl, H; Sobhian, B, 2012) |
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| " Our aim was to test whether polylactic acid-polyglycolic acid copolymer(PLGA)/collagen type I(CoI) microspheres combined with BMSCs could be used as injectable scaffolds to improve bone quality in osteoporotic female rats." | 1.38 | Improvement of intertrochanteric bone quality in osteoporotic female rats after injection of polylactic acid-polyglycolic acid copolymer/collagen type I microspheres combined with bone mesenchymal stem cells. ( Li, C; Liu, X; Shi, X; Sun, H; Yang, X; Yu, Z; Zhu, T, 2012) |
| "Cryptococcosis is a leading mycological cause of mortality among immunologically compromised individuals." | 1.38 | Vaccine potential of cytosolic proteins loaded fibrin microspheres of Cryptococcus neoformans in BALB/c mice. ( Chauhan, A; Jabeen, M; Khan, AA; Owais, M, 2012) |
| "Proximal Spinal Muscular Atrophy (SMA) is a debilitating neuromuscular disease and a leading inherited genetic cause of infant death." | 1.38 | Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression. ( Beltran, JA; Charney, R; Chomicova, O; Cirillo, K; El-Khodor, BF; Marino, T; Mushlin, R; Ramboz, S; Winberg, ML, 2012) |
| "Neuronal injury in pneumococcal meningitis is a consequence of microglial activation and direct toxicity by bacterial products and systemic inflammation." | 1.38 | Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis. ( Gerber, J; Nau, R; Redlich, S; Ribes, S; Schmidt, H; Tauber, SC, 2012) |
| "Maternal obesity was associated with a significant delay in precompaction cell cycle kinetics from the 1-cell stage." | 1.38 | Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst. ( Binder, NK; Gardner, DK; Mitchell, M, 2012) |
| "Titanium implants were planted into the tibias of the diabetic rats and into 10 normal rats." | 1.38 | Effects of local delivery of bFGF from PLGA microspheres on osseointegration around implants in diabetic rats. ( Deng, ZX; Li, DH; Liang, LH; Song, YL; Sun, DC; Yu, M; Zhou, W; Zhu, WZ; Zou, GK, 2012) |
| " The results of this study demonstrate a plausible novel anticonvulsant activity of β-carotene at a low dose of 2 mg/kg, with brain-targeted nanodelivery, thus increasing its bioavailability and stability." | 1.38 | Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles. ( Ahmed, B; Khan, M; Khan, RA; Yusuf, M, 2012) |
| "Despite treatment, this syndrome complicated the interpretation of blood glucose readings as a measure of islet graft function and resulted in death or the need for euthanasia in all seven animals." | 1.38 | A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis. ( Bottino, R; Cooper, DK; Dons, EM; Echeverri, GJ; Rigatti, LH; van der Windt, DJ; Wagner, R; Wijkstrom, M; Zhou, H, 2012) |
| "Recently, the clinical spectrum of dominant optic atrophy has been extended to frequent syndromic forms, exhibiting various degrees of neurological and muscle impairments frequently found in mitochondrial diseases." | 1.38 | The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. ( Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J, 2012) |
| "In dogs submitted to pressure-guided hemorrhagic shock and fixed-volume resuscitation, the smaller intravascular volume expansion from HHES solutions provides worse recovery of systemic oxygenation and gastric perfusion compared with LR and HES solutions despite its high volume expansion efficiency, which was limited by low infused volume." | 1.37 | The effects of 6% hydroxyethyl starch-hypertonic saline in resuscitation of dogs with hemorrhagic shock. ( Barros, JM; Braz, JR; Braz, LG; Carvalho, LR; Castiglia, YM; do Nascimento, P; Marinello, JL; Vane, LA, 2011) |
| "Cerebral arterial gas embolism is a risk in diving and occurs as a complication in surgery and interventional radiology." | 1.37 | Cerebral arterial gas embolism in swine. Comparison of two sites for air injection. ( Ghazi-Hosseini, E; Hollmann, MW; Stevens, MF; van Gulik, TM; van Hulst, RA; van Lienden, KP; Weenink, RP, 2011) |
| "Metabolic syndrome is a disease that today affects millions of people around the world." | 1.37 | Impact of early fructose intake on metabolic profile and aerobic capacity of rats. ( Botezelli, JD; Cambri, LT; Ghezzi, AC; Mello, MA; Ribeiro, C, 2011) |
| "Halothane was discontinued after the administration of 0." | 1.37 | Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. ( Becker, S; Burmester, S; Gerbershagen, MU; Kröner, L; Lenz, D; Schütte, JK; Starosse, A; Wappler, F, 2011) |
| "This experimental protocol of hemorrhagic shock and fluid resuscitation in Landrace-Large White swine may be useful for future study of hemorrhagic shock and acute lung injury." | 1.37 | A model of hemorrhagic shock and acute lung injury in Landrace-Large White Swine. ( Agrogiannis, GD; Balkamou, XA; Demestiha, TD; Pantazopoulos, IN; Rokas, GI; Skandalakis, PN; Stroumpoulis, KI; Troupis, GT; Xanthos, TT, 2011) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Under conditions of septic shock, an increase in lactate levels was found to be a sensitive marker of tissue metabolism disorder." | 1.37 | Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model. ( Hanyu, N; Hosoyama, A; Kawasaki, N; Kobayashi, K; Komatsu, H; Ohashi, H; Ohashi, M; Taira, Y; Wada, T, 2011) |
| "Obesity is a highly prevalent condition associated with several diseases." | 1.37 | Assessment of aerobic capacity during swimming exercise in ob/ob mice. ( Almeida, WS; Araújo, RC; Barros, CC; Campbell, CS; Cunha, VN; Lima, LC; R Cunha, R; Simões, HG, 2011) |
| " Hence, these microspheres may be potentially useful in the clinical setting with the need for further investigation for optimal dosing of TCP–PLGA microspheres." | 1.36 | Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis. ( Ahiskali, R; Cevher, E; Mülazimoğlu, L; Orhan, Z; Sensoy, D; Yildiz, A, 2010) |
| "We utilized a global cerebral ischemia model induced by arresting the heart with a combination of hypovolemia and intracardiac injections of a cold potassium chloride solution in order to study the potential therapeutic benefits of human mesenchymal stem cells (hMSCs) on global cerebral ischemia." | 1.36 | Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. ( Hamada, H; Harada, K; Honmou, O; Houkin, K; Kocsis, JD; Liu, H; Miyata, K; Suzuki, J; Zheng, W, 2010) |
| "This paper presents the pharmacokinetic of human growth hormone (hGH) implantable tablets tested on a human ovarian cancer mouse model." | 1.36 | Pharmacokinetics analysis of sustained release hGH biodegradable implantable tablets using a mouse model of human ovarian cancer. ( Dannies, P; Fariña, JB; Llabrés, M; Santoveña, A; Zhu, Y, 2010) |
| "In studies using orthotopic mouse bladder cancer, the tumor loads in R-837-treated mice were significantly lower than those in vehicle-treated or non-treated mice." | 1.36 | Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. ( Barberis, A; Carson, DA; Chan, M; Corr, M; Cottam, HB; Crain, B; Hayashi, T; Leoni, L; Maj, R, 2010) |
| "Heatstroke was induced by putting the animals in a folded heating pad of 42°C for 68 minutes controlled by circulating hot water." | 1.36 | Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury. ( Ching-Ping, C; Hsi-Hsing, Y; Juei-Tang, C; Lin, MT, 2010) |
| " The pharmacodynamic performances of the nanoparticles (NPs) were evaluated for brain targeting and memory improvement in scopolamine-induced amnesic mice using Morris Water Maze Test." | 1.36 | Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies. ( Chavhan, SS; Joshi, SA; Sawant, KK, 2010) |
| "Acute colitis was induced with dextran sulfate sodium (DSS) for 7 days following administration of phosphate buffered saline for 7 days (DSS-treated group, n = 5)." | 1.36 | 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model. ( Ahn, YT; Hong, YS; Huh, CS; Hwang, GS; Kim, DH; Lee, H; Lee, JH; Park, JC; Ryu, DH, 2010) |
| " At the dosage of 500 microg/mL, the viability of hepatoma Hep3B cells was approximately 2." | 1.36 | Antihepatocarcinoma activity of lactic acid bacteria fermented Panax notoginseng. ( Chiang, BH; Lin, YW; Mou, YC; Su, CC, 2010) |
| " Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "We evaluated the efficacy of diaphragmatic hernia repair in a rat model using a poly-lactic-co-glycolic acid (PLGA) mesh-collagen sponge hybrid scaffold, designed for in situ tissue engineering." | 1.35 | Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold: an experimental study in a rat model. ( Chen, G; Kaneko, M; Komuro, H; Saihara, R; Shinya, M; Urita, Y, 2008) |
| "Nutritional interventions for intrauterine growth restriction (IUGR) have raised concerns for fetal toxicity, the mechanisms of which are unknown." | 1.35 | Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. ( Barry, JS; Brown, LD; Hay, WW; Limesand, SW; Rozance, PJ, 2009) |
| "The high recurrence and lethality of ovarian cancer at advanced stages is problematic, especially due to the development of numerous micrometastases scattered throughout the abdominal cavity." | 1.35 | Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. ( Delie, F; Gurny, R; Lange, N; Zeisser-Labouèbe, M, 2009) |
| "Similarly, a trend for less kyphosis was evident in the fixed group (7." | 1.35 | Rigid fixation of the spinal column improves scaffold alignment and prevents scoliosis in the transected rat spinal cord. ( Ameenuddin, S; Chen, B; Currier, BL; Knight, A; Macura, SI; Mishra, PK; Rooney, GE; Schiefer, TK; Spinner, RJ; Vaishya, S; Windebank, AJ; Yaszemski, MJ, 2008) |
| "and results Left ventricular hypertrophy was induced surgically in Sprague-Dawley rats by inter-renal aortic constriction." | 1.35 | Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy. ( Akki, A; Seymour, AM, 2009) |
| "Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion." | 1.35 | Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. ( Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH, 2008) |
| "Although hydrocephalus is usually considered a disorder of periventricular white matter, disturbance of gray matter is probably also involved." | 1.35 | Gray matter metabolism in acute and chronic hydrocephalus. ( Eyjolfsson, EM; Kondziella, D; Risa, O; Saether, O; Sonnewald, U, 2009) |
| "Thoracoabdominal aortic aneurysm open surgery is accompanied by a significant incidence of renal failure due to renal ischemia." | 1.35 | Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach. ( Charalambopoulos, A; Giamarellos-Bourboulis, EJ; Kakisis, JD; Karatzas, GM; Karkaletsis, KG; Lazaris, AM; Liakakos, TD; Maheras, AN; Martikos, G; Patapis, P; Vasdekis, SN, 2009) |
| "Both lactic acid and morphine were equipotent in the stretching and ICSS procedures." | 1.35 | Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. ( Carlezon, WA; Negus, SS; Pereira Do Carmo, G; Stevenson, GW, 2009) |
| "Cardiac fibrosis was significantly reduced by ONO-1301-PLGA (p<0." | 1.35 | Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters. ( Akaike, M; Hirata, Y; Igarashi, T; Sakai, Y; Sata, M; Soeki, T, 2009) |
| "Repaglinide (RPG) is an oral hypoglycemic agent with excellent bioavailability (90-98%) and a short plasma half-life (2-6 h)." | 1.35 | Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus. ( Jain, S; Saraf, S, 2009) |
| "Atorvastatin calcium (AC) is a second-generation 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor approved for clinical use as a lipid lowering agent." | 1.35 | Oral nanoparticulate atorvastatin calcium is more efficient and safe in comparison to Lipicure in treating hyperlipidemia. ( Ankola, DD; Chandraiah, G; Kumar, MN; Meena, AK; Rao, PR; Ratnam, DV, 2008) |
| "Dermal fibrosis was histologically observed at day 7 after injection and remained present at day 21." | 1.35 | Mouse model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres. ( Ishikawa, O; Negishi, I; Shibusawa, Y; Tabata, Y, 2008) |
| "Rodent model of irreversible hemorrhagic shock was reproduced." | 1.35 | [Hemorrheological changes in irreversible hemorrhagic shock]. ( Su, LY; Wang, B; Wang, ZL; You, GX; Yu, L; Zhao, L; Zhou, H, 2008) |
| "Severe fetal growth restriction (FGR) is often associated with hypoxia." | 1.34 | Development and mechanisms of fetal hypoxia in severe fetal growth restriction. ( Battaglia, FC; de Vrijer, B; Galan, HL; Meschia, G; Regnault, TR; Wilkening, RB, 2007) |
| "Rabbits whose cerebral vasospasm were 50% or over 50% (n=7) and NSS is lesser than 3 were termed as groups 2, and rabbits whose cerebral vasospasm were 50% or above 50% (n=7) and NSS is greater than 3 were termed groups 3." | 1.34 | Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status. ( Ak, A; Cengiz, SL; Karaköse, S; Ustün, ME, 2007) |
| " The fatigue task altered the dose-response relationship to intramuscular acidic saline injections." | 1.34 | Muscle fatigue increases the probability of developing hyperalgesia in mice. ( Lisi, TL; Moore, SA; Sluka, KA; Yokoyama, T, 2007) |
| "We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP)." | 1.34 | Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure. ( Belanger, M; Davies, NA; Jalan, R; Nedredal, GI; Revhaug, A; Rose, C; Sen, S; Ytrebø, LM, 2007) |
| "Additionally, the lipid content in pancreatic cancer was higher than that in chronic pancreatitis." | 1.34 | Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis. ( Chen, Q; Deng, H; Fang, F; He, X; Lu, J; Spraul, M; Yu, Y, 2007) |
| "Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction." | 1.34 | Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction. ( Andrews, PL; Brooks, HF; Davies, DC; Moss, RF; Osabutey, CK, 2007) |
| "Streptomycin levels were maintained for 4 days in the plasma and for 7 days in the organs following a single oral administration of PLG nanoparticles." | 1.34 | Nanoparticle-based oral drug delivery system for an injectable antibiotic - streptomycin. Evaluation in a murine tuberculosis model. ( Khuller, GK; Pandey, R, 2007) |
| "In this model of hemorrhagic shock, hypertonic HBOC-201- resuscitated pigs had significantly reduced SVR and PVR, as well as mean pulmonary artery pressure (MPAP) and increased cardiac output." | 1.34 | Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201. ( Brown, R; Huerta, S; Minei, JP; Rivera-Chavez, FA; York, GB, 2007) |
| "A model of rat with severe hemorrhagic shock and active bleeding was established in 32 Sprague-Dawley rats." | 1.34 | Experimental study of controlled fluid resuscitation in the treatment of severe and uncontrolled hemorrhagic shock. ( Bao, DG; Cai, XJ; Gu, LH; Huang, WD; Lu, YQ; Wang, Q, 2007) |
| "D-mannose is an essential monosaccharide constituent of glycoproteins and glycolipids." | 1.33 | Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration. ( Asano, N; Miwa, I; Mizutani, T; Nakajima, H; Taguchi, T; Yabuuchi, M; Yamashita, E, 2005) |
| "Heatstroke is characterized by hyperthermia, vasoplegic shock, and cerebral ischemia and hypoxia." | 1.33 | Resuscitation from experimental heatstroke by hyperbaric oxygen therapy. ( Gao, CJ; Li, WX; Lin, MT; Niu, KC; Tsai, HM, 2005) |
| "Hemorrhagic shock was induced in five male domestic pigs." | 1.33 | Increases in both buccal and sublingual partial pressure of carbon dioxide reflect decreases of tissue blood flows in a porcine model during hemorrhagic shock. ( Castillo, C; Csapozi, P; Pellis, T; Sun, S; Tang, W; Weil, MH, 2005) |
| "Transient (2 hours) middle cerebral artery occlusion (MCAO) was performed in eight macaque monkeys." | 1.33 | Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates. ( Enblad, P; Frykholm, P; Hillered, L; Långström, B; Persson, L; Valtysson, J, 2005) |
| "Hemorrhagic shock is a common cause of death in emergency rooms." | 1.33 | The physiological changes of cumulative hemorrhagic shock in conscious rats. ( Chang, FM; Chao, YF; Harn, HJ; Lai, HL; Lee, RP; Liao, KW; Peng, TC, 2006) |
| "Neonatal anoxia was induced by placing 2-day-old rat pups into a glass chamber with 100% N(2) atmosphere, T=36." | 1.33 | Selected biochemical variables in a model of neonatal anoxia in rats. ( Dubovický, M; Mach, M; Navarová, J; Schmidtová, M; Ujházy, E, 2006) |
| "To introduce an animal model of hepatocellular carcinoma (HCC) in ACI-rats, and to evaluate the therapeutic effects of Poly-lactide-co-glycolide (Plcg) -microspheres in the transarterial chemoembolization (TACE) in this model, as well the value of this model in the experiments of interventional therapy." | 1.32 | Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma. ( Claussen, C; Eul, T; Graepler, F; Huppert, P; Pereira, P; Qian, J; Truebenbach, J; Wiemann, G, 2003) |
| "Two weeks after induction of hydrocephalus the taurine concentration was decreased, whereas the concentration of [1,2-13C]lactate was increased in the cerebrum and that of [1,2-13C]GABA in the brainstem." | 1.32 | Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. ( Brinker, T; Kondziella, D; Lüdemann, W; Qu, H; Sletvold, O; Sonnewald, U, 2003) |
| "Echocardiography demonstrated that right ventricular dysfunction occurred in the absence of recruitment." | 1.32 | Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. ( Ackerley, C; Duggan, M; Engelberts, D; Kavanagh, BP; McCaul, CL; McNamara, PJ, 2003) |
| "Myocardial infarction was induced by occlusion of major branches of the left anterior descending coronary artery for 60 min followed by 120 min of reperfusion in 26 sheep." | 1.32 | Left ventricular support by catheter-mounted axial flow pump reduces infarct size. ( Flameng, W; Leunens, V; Meyns, B; Stolinski, J; Verbeken, E, 2003) |
| "Stress hyperglycemia is frequent in critically ill patients." | 1.32 | Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. ( Coopmans, W; Giulietti, AP; Mathieu, C; Michalaki, M; Van den Berghe, G; Van Herck, E; Weekers, F, 2003) |
| "Coronary flow reserve in the same brain death model was assessed by changes in coronary flow and resistance induced by administering a vasodilator directly into the coronary artery in another eight dogs." | 1.32 | Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart. ( Imasaka, K; Kajihara, N; Masuda, M; Morita, S; Nishimura, Y; Oishi, Y; Yasui, H, 2003) |
| "SCA3 or Machado-Joseph disease (MJD) is the commonest dominant inherited ataxia disease, with pathological phenotypes apparent with a CAG triplet repeat length of 61-84." | 1.32 | Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. ( Cemal, CK; Griffin, JL; Pook, MA, 2004) |
| "Patients with septic shock commonly have myocardial dysfunction associated with lactic acid production and troponin I release." | 1.32 | Effects of intraaortic balloon augmentation in a porcine model of endotoxemic shock. ( Engoren, M; Habib, RH, 2004) |
| "Osteomyelitis was established in 40 New Zealand White rabbits using Staphylococcus aureus." | 1.32 | Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model. ( Ambrose, CG; Clyburn, TA; Gogola, GR; Gulati, P; Joseph, J; Louden, K; Mikos, AG; Wright, J, 2004) |
| "D-xylose content was increased at I/R1 and I/RL groups (both P<0." | 1.32 | [Change in intestinal function in sepsis in rat]. ( Hu, S; Jiang, XG; Jin, H; Li, JY; Lu, Y; Sheng, ZY; Sun, D, 2004) |
| "Focal cerebral ischemia was induced by occlusion of the unilateral common carotid artery and the middle cerebral artery for 60 minutes followed by 180 minutes of reperfusion." | 1.32 | Microdialysis analyzer and flame atomic absorption spectrometry in the determination of blood glucose, lactate and magnesium in gerbils subjected to cerebral ischemia/reperfusion. ( Cheng, FC; Huang, YL; Lee, JB; Lin, MC; Liu, HW; Yang, DY, 2004) |
| "Since the moribund hypodynamic phase of septic shock has primarily been studied in small animal models, the objective of this study was to investigate the usefulness of infusing Salmonella typhosa endotoxin at incrementing doses to establish an ovine model of hypodynamic endotoxaemia." | 1.32 | New approach to an ovine model of hypodynamic endotoxaemia. ( Bone, HG; Booke, M; Daudel, F; Sander, J; Stubbe, H; Van Aken, H; Westphal, M, 2004) |
| "This method was applied in MCF7 human breast cancer implanted in the mammary gland of female CD1-NU mice and was further employed to assess tumor response to hormonal manipulation with the antiestrogen tamoxifen." | 1.31 | Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS. ( Degani, H; Margalit, R; Rivenzon-Segal, D, 2002) |
| "Lactic acidosis is an important complication of septic shock." | 1.31 | Blood pH level modulates organ metabolism of lactate in septic shock in dogs. ( Bautista, E; Bose, D; Chrusch, C; Duke, K; Jacobs, HK; Light, RB; Mink, SN, 2002) |
| "AIDS-related Kaposi's sarcoma (AIDS-KS), the most prevalent HIV-associated malignancy, is a debilitating, potentially fatal disease." | 1.31 | Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts. ( Kang, J; Mallery, SR; Ness, GM; Pei, P; Schwendeman, SP; Zhu, G, 2000) |
| "Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied." | 1.31 | Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2001) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 1.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| "The aim of the current study was to assess the effects of epinephrine in a pig model of hypothermic cardiac arrest followed by closed-chest cardiopulmonary resuscitation combined with active rewarming, simulating the clinical management of an arrested hypothermic patient in a hospital without cardiopulmonary bypass facilities." | 1.31 | Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming. ( Kornberger, E; Krismer, AC; Lindner, KH; Mair, P; Mayr, VD; Rackwitz, KS; Schwarz, B; Wenzel, V, 2001) |
| "The mean occlusion time until cardiac arrest was 14." | 1.31 | Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs. ( Hellström-Westas, L; Hernandez-Andrade, E; Ley, D; Lingman, G; Marsal, K; Ohlsson, T; Oskarsson, G; Pesonen, E; Sandell, A; Strand, SE; Thorngren-Jerneck, K; Werner, O, 2001) |
| " Two different in vivo studies were performed, the first to find the dosage level of dexamethasone that effectively would suppress the acute inflammatory reaction and the second to show how effective the dexamethasone delivered by PLGA microspheres was in suppressing chronic inflammatory response to an implant." | 1.31 | In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices. ( Burgess, DJ; Hickey, T; Kreutzer, D; Moussy, F, 2002) |
| "Glycerol was progressively released during prolonged ischemia." | 1.31 | Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis. ( Bäckström, T; Franco-Cereceda, A; Liska, J; Lockowandt, U; Sylven, C, 2002) |
| " coli dosage (1 x 10(10) E." | 1.30 | Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis. ( Burchardi, H; Goldmann, K; Götze, O; Höpken, U; Mathes, C; Mohr, M; Oppermann, M; Siever, S, 1998) |
| "This quantitative model of hemorrhagic shock showed that tissue oxygenation parameters can be used to monitor the progression from the decompensated phase of hemorrhagic shock to irreversibility." | 1.30 | Utility of clinical parameters of tissue oxygenation in a quantitative model of irreversible hemorrhagic shock. ( Billiar, TR; Harbrecht, BG; Kelly, E; Marshall, HM; Peitzman, AB; Shah, NS; Udekwu, AO, 1998) |
| "In case of fatal hydrocephalus, high lactate levels were observed throughout the whole brain." | 1.30 | In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus. ( Braun, KP; de Graaf, RA; Gooskens, RH; Nicolay, K; Tulleken, KA; Vandertop, WP, 1998) |
| "Osteomyelitis is generally treated by the systemic administration of antibiotics and continuous irrigation after curettage of the lesion, and bone graft is performed secondarily to treat any bone defect." | 1.30 | Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis. ( Ishii, Y; Sasaki, S, 1999) |
| "Pretreatment with diazoxide (10 mg." | 1.29 | Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats. ( Ichihara, K; Nakai, T, 1994) |
| "To observe the influence of prolonged cardiac arrest times on neurologic outcome and heart resuscitability, using a resuscitation model with cardiopulmonary bypass in the rabbit, and to determine whether the changes in the plasma concentrations of lactate and lipoperoxide correlate with the severity of global brain ischemia." | 1.29 | Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits. ( Ogata, H; Xu, X, 1994) |
| "We conclude that brain death leads to early impaired left ventricular contractility, which could be responsible for the changes observed in aerobic to anaerobic metabolism in response to rapid volume infusion." | 1.29 | Changes in hemodynamic and metabolic parameters following induced brain death in the pig. ( Boulange, M; Burlet, C; Burtin, P; Carteaux, JP; el Abassi, K; Jaboin, Y; Mertes, PM; Pinelli, G; Villemot, JP, 1994) |
| "The lactic acid value was significantly higher in peritoneal fluid than in plasma in patients who were found to have hollow viscus perforation, gangrenous intestine, peritonitis, or intra-abdominal abscess." | 1.29 | Peritoneal fluid lactic acid and diagnostic dilemmas in acute abdominal disease. ( DeLaurier, GA; Ivey, RK; Johnson, RH, 1994) |
| "Prolonged hemorrhagic shock is characterized by the progression from hyperglycemia to hypoglycemia and failure to respond to standard methods of resuscitation." | 1.29 | Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock. ( Drourr, N; Geller, ER; Higgins, LD; Maitra, SR, 1993) |
| "Gravity-induced loss of consciousness (G-LOC) is known to have occurred in pilots since the early 1920's." | 1.29 | Acceleration-induced effects on baboon blood chemistry. ( Barber, J; Shahed, AR; Werchan, PM, 1993) |
| "Flunarizine is a class IV calcium channel blocker which increases oxygen delivery to hypoxic regions in solid tumours, exerting a radiosensitising effect in vivo in animal tumour models." | 1.29 | The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. ( Coffey, BE; Dewhirst, MW; Hochmuth, RM; Kavanagh, BD; Needham, D, 1993) |
| "Inflammation was induced by the placement of a catheter in the carotid artery." | 1.29 | Potentiation of decreased pyruvate dehydrogenase activity by inflammatory stimuli in sepsis. ( Martin, LF; Vary, TC, 1993) |
| "Lactic acid was found in lower concentrations in Fe, Cu, Cu + F, Cu + Fe and F + Fe groups than in the other groups." | 1.29 | Effects of copper, iron and fluoride co-crystallized with sugar on caries development and acid formation in deslivated rats. ( Bowen, WH; Pearson, SK; Rosalen, PL, 1996) |
| "Ibuprofen pretreatment increases arterial pressure and reduces mortality in endotoxic dogs." | 1.28 | Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment. ( Pinsky, MR, 1992) |
| " Because higher doses of DCA may be more effective, the main objective of our study was to examine the dose-response of brain tissue lactate to DCA." | 1.28 | Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. ( Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "Models of post-ischemic acute renal failure were prepared in rats." | 1.27 | [Effect of adenosine triphosphate-magnesium chloride administration for post-ischemic acute renal failure (I)]. ( Arao, S; Asahi, T; Handa, T; Kawazoe, S; Nakazawa, T; Shimizu, K; Shiraishi, M; Tanaka, S, 1983) |
| "Postischemic acute renal failure was induced by 1 hr of clamping of the renal vasculature." | 1.27 | Metabolic studies of postischemic acute renal failure in the rat. ( Cowley, RA; Kahng, MW; Trifillis, AL; Trump, BF, 1984) |
| "It is well established that septic shock is caused by Gram-negative endotoxemia, and is characterized by hyperdynamic state being observed in the early stage of shock." | 1.27 | [Hyperdynamic state induced by continuous infusion of E. coli endotoxin in dogs]. ( Wu, TT, 1985) |
| " Chronic administration of lithium was found to prevent the development of hyperreactivity to mild footshock, while chronic electroconvulsive shock effected a return toward normal behavior." | 1.26 | A pharmacologically pertinent animal model of mania. ( Petty, F; Sherman, AD, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (2.20) | 18.7374 |
| 1990's | 128 (11.26) | 18.2507 |
| 2000's | 338 (29.73) | 29.6817 |
| 2010's | 560 (49.25) | 24.3611 |
| 2020's | 86 (7.56) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Wang, Y | 13 |
| Peng, Y | 1 |
| Zhang, C | 3 |
| Zhou, X | 2 |
| Sugiura, T | 1 |
| Okumura, K | 1 |
| Matsumoto, J | 1 |
| Sakaguchi, M | 1 |
| Komori, T | 1 |
| Ogi, T | 1 |
| Inoue, D | 1 |
| Koda, W | 1 |
| Kobayashi, S | 1 |
| Gabata, T | 1 |
| Sun, S | 4 |
| Xu, X | 6 |
| Liang, L | 1 |
| Wang, X | 10 |
| Bai, X | 1 |
| Zhu, L | 1 |
| He, Q | 1 |
| Liang, H | 4 |
| Xin, X | 2 |
| Wang, L | 13 |
| Lou, C | 1 |
| Cao, X | 1 |
| Chen, X | 5 |
| Li, B | 3 |
| Wang, B | 3 |
| Zhao, J | 5 |
| Chang, MY | 1 |
| Tsai, CY | 1 |
| Chou, LF | 1 |
| Hsu, SH | 1 |
| Yang, HY | 1 |
| Hung, CC | 1 |
| Tian, YC | 1 |
| Ong, ACM | 1 |
| Yang, CW | 1 |
| Jones, AK | 1 |
| Wang, D | 4 |
| Goldstrohm, DA | 1 |
| Brown, LD | 2 |
| Rozance, PJ | 2 |
| Limesand, SW | 2 |
| Wesolowski, SR | 1 |
| Mohamed, AB | 1 |
| Rémond, D | 1 |
| Gual-Grau, A | 1 |
| Bernalier-Donnadille, A | 1 |
| Capel, F | 1 |
| Michalski, MC | 1 |
| Laugerette, F | 1 |
| Cohade, B | 1 |
| Hafnaoui, N | 1 |
| Béchet, D | 1 |
| Coudy-Gandilhon, C | 1 |
| Gueugneau, M | 1 |
| Salles, J | 1 |
| Migné, C | 1 |
| Dardevet, D | 1 |
| David, J | 1 |
| Polakof, S | 1 |
| Savary-Auzeloux, I | 1 |
| Gao, L | 3 |
| Xu, QH | 1 |
| Ma, LN | 1 |
| Luo, J | 1 |
| Muyayalo, KP | 1 |
| Wang, LL | 2 |
| Huang, DH | 1 |
| Xiao, XJ | 1 |
| Cheng, SB | 1 |
| Mor, G | 1 |
| Liao, AH | 1 |
| Hao, Q | 1 |
| Huang, Z | 1 |
| Li, Q | 6 |
| Liu, D | 2 |
| Wang, P | 4 |
| Wang, K | 3 |
| Li, J | 18 |
| Cao, W | 1 |
| Deng, W | 1 |
| Wu, K | 1 |
| Su, R | 2 |
| Liu, Z | 7 |
| Vadgama, J | 1 |
| Wu, Y | 4 |
| Li, M | 2 |
| Wang, S | 7 |
| Liu, X | 8 |
| Sheng, Z | 2 |
| Zhang, J | 12 |
| Zhang, Z | 8 |
| Wiwatchaitawee, K | 1 |
| Ebeid, K | 1 |
| Quarterman, JC | 1 |
| Naguib, Y | 1 |
| Ali, MY | 1 |
| Oliva, C | 1 |
| Griguer, C | 1 |
| Salem, AK | 2 |
| Nelson, TS | 2 |
| Simpson, C | 1 |
| Dyka, F | 1 |
| Dinculescu, A | 1 |
| Smith, WC | 1 |
| Kumagai, S | 1 |
| Koyama, S | 1 |
| Itahashi, K | 1 |
| Tanegashima, T | 1 |
| Lin, YT | 1 |
| Togashi, Y | 1 |
| Kamada, T | 1 |
| Irie, T | 1 |
| Okumura, G | 1 |
| Kono, H | 1 |
| Ito, D | 1 |
| Fujii, R | 1 |
| Watanabe, S | 2 |
| Sai, A | 1 |
| Fukuoka, S | 1 |
| Sugiyama, E | 1 |
| Watanabe, G | 1 |
| Owari, T | 1 |
| Nishinakamura, H | 1 |
| Sugiyama, D | 1 |
| Maeda, Y | 1 |
| Kawazoe, A | 1 |
| Yukami, H | 1 |
| Chida, K | 1 |
| Ohara, Y | 1 |
| Yoshida, T | 1 |
| Shinno, Y | 1 |
| Takeyasu, Y | 1 |
| Shirasawa, M | 1 |
| Nakama, K | 1 |
| Aokage, K | 1 |
| Suzuki, J | 2 |
| Ishii, G | 1 |
| Kuwata, T | 1 |
| Sakamoto, N | 1 |
| Kawazu, M | 1 |
| Ueno, T | 1 |
| Mori, T | 1 |
| Yamazaki, N | 1 |
| Tsuboi, M | 1 |
| Yatabe, Y | 1 |
| Kinoshita, T | 1 |
| Doi, T | 1 |
| Shitara, K | 1 |
| Mano, H | 1 |
| Nishikawa, H | 1 |
| Rydenfelt, K | 1 |
| Strand-Amundsen, R | 1 |
| Horneland, R | 1 |
| Hødnebø, S | 1 |
| Kjøsen, G | 1 |
| Pischke, SE | 2 |
| Tønnessen, TI | 2 |
| Haugaa, H | 2 |
| Koerich, S | 1 |
| Silva, FC | 1 |
| Itinose, AM | 1 |
| Bellozi, PMQ | 1 |
| Sandrini, F | 1 |
| Schneider, SCS | 1 |
| Marek, CB | 1 |
| Ghareghani, M | 2 |
| Farhadi, Z | 1 |
| Rivest, S | 1 |
| Zibara, K | 1 |
| Li, VL | 1 |
| He, Y | 2 |
| Contrepois, K | 1 |
| Liu, H | 7 |
| Kim, JT | 2 |
| Wiggenhorn, AL | 1 |
| Tanzo, JT | 1 |
| Tung, AS | 1 |
| Lyu, X | 1 |
| Zushin, PH | 1 |
| Jansen, RS | 1 |
| Michael, B | 1 |
| Loh, KY | 1 |
| Yang, AC | 1 |
| Carl, CS | 1 |
| Voldstedlund, CT | 1 |
| Wei, W | 1 |
| Terrell, SM | 1 |
| Moeller, BC | 1 |
| Arthur, RM | 1 |
| Wallis, GA | 1 |
| van de Wetering, K | 1 |
| Stahl, A | 1 |
| Kiens, B | 1 |
| Richter, EA | 1 |
| Banik, SM | 1 |
| Snyder, MP | 1 |
| Xu, Y | 5 |
| Long, JZ | 1 |
| Kale, A | 1 |
| Joshi, D | 1 |
| Menon, I | 1 |
| Bagwe, P | 1 |
| Patil, S | 1 |
| Vijayanand, S | 1 |
| Braz Gomes, K | 1 |
| D'Souza, M | 1 |
| Cieminski, K | 1 |
| Flis, DJ | 1 |
| Dzik, KP | 1 |
| Kaczor, JJ | 1 |
| Wieckowski, MR | 1 |
| Antosiewicz, J | 1 |
| Ziolkowski, W | 1 |
| Zhou, HC | 1 |
| Yu, WW | 1 |
| Yan, XY | 1 |
| Liang, XQ | 1 |
| Ma, XF | 1 |
| Long, JP | 1 |
| Du, XY | 1 |
| Mao, HY | 1 |
| Liu, HB | 1 |
| Sun, J | 4 |
| Feng, M | 1 |
| Zou, H | 4 |
| Mao, Y | 1 |
| Yu, W | 4 |
| Gonçalves-Ferri, WA | 3 |
| Albuquerque, AAS | 3 |
| de Castro, RSAP | 3 |
| Ferreira, CHF | 3 |
| Oharomari, LK | 3 |
| Silva Lessa, DF | 3 |
| Evora, PRB | 3 |
| Tian, YM | 1 |
| Hu, S | 4 |
| Zhang, HP | 3 |
| Meng, XX | 1 |
| Zhong, YX | 2 |
| Du, MH | 1 |
| Ding, Y | 2 |
| Patel, N | 1 |
| Johnson, MA | 2 |
| Vapniarsky, N | 1 |
| Van Brocklin, MW | 1 |
| Williams, TK | 2 |
| Youngquist, ST | 1 |
| Ford, R | 1 |
| Ewer, N | 1 |
| Neff, LP | 2 |
| Hoareau, GL | 3 |
| Song, R | 1 |
| Chai, T | 1 |
| Liu, J | 5 |
| Chu, A | 1 |
| Sun, C | 2 |
| Zhao, Y | 5 |
| Gao, J | 2 |
| Li, C | 5 |
| Song, G | 1 |
| Shan, Y | 1 |
| Geiseler, SJ | 1 |
| Phan, KD | 1 |
| Brox, C | 1 |
| Nguyen, TD | 1 |
| Tartanoglu, C | 1 |
| Doosje, HL | 1 |
| Christiansen, CL | 1 |
| Liesz, A | 1 |
| Morland, C | 1 |
| Downing, G | 1 |
| Olsen, KF | 1 |
| Sawyer, TK | 1 |
| Cone, RD | 1 |
| Schwendeman, SP | 3 |
| Song, EJ | 1 |
| Lee, ES | 1 |
| Kim, YI | 1 |
| Shin, DU | 1 |
| Eom, JE | 1 |
| Shin, HS | 1 |
| Lee, SY | 1 |
| Nam, YD | 1 |
| Zhu, X | 1 |
| Wang, H | 3 |
| Gasior, FM | 1 |
| Lee, C | 1 |
| Lin, S | 1 |
| Justice, CN | 1 |
| O'Donnell, JM | 1 |
| Vanden Hoek, TL | 1 |
| Montrazi, ET | 1 |
| Sasson, K | 2 |
| Agemy, L | 2 |
| Peters, DC | 1 |
| Brenner, O | 1 |
| Scherz, A | 2 |
| Frydman, L | 4 |
| Dommerholt, J | 1 |
| Hooks, T | 1 |
| Chou, LW | 1 |
| Finnegan, M | 1 |
| Xu, J | 5 |
| Ma, X | 3 |
| Yu, K | 4 |
| Wang, R | 2 |
| Liu, R | 2 |
| Gao, H | 1 |
| Wang, C | 2 |
| Shi, J | 3 |
| Wang, Z | 9 |
| Kurra, S | 1 |
| Niu, J | 1 |
| Yang, H | 1 |
| Yuan, Y | 2 |
| Sun, L | 1 |
| Chen, J | 5 |
| Jia, M | 1 |
| Zou, Y | 1 |
| Sa, H | 1 |
| Cai, Y | 2 |
| Guo, Y | 1 |
| Li, H | 5 |
| Ma, K | 1 |
| Ding, C | 1 |
| Wu, Z | 4 |
| You, H | 1 |
| Ge, H | 1 |
| Zheng, S | 1 |
| Lin, Y | 3 |
| Wu, X | 4 |
| Lin, Z | 2 |
| Kang, D | 1 |
| Ayres, JS | 1 |
| Ye, Z | 1 |
| Wu, C | 1 |
| Zhang, N | 3 |
| Du, L | 1 |
| Cao, Q | 1 |
| Huang, X | 2 |
| Tang, J | 2 |
| Wang, Q | 5 |
| Li, F | 1 |
| Zhou, C | 2 |
| Xu, Q | 3 |
| Xiong, X | 1 |
| Kijlstra, A | 1 |
| Qin, N | 1 |
| Yang, P | 1 |
| Chen, SM | 2 |
| Lin, CE | 2 |
| Chen, HH | 1 |
| Cheng, YF | 1 |
| Cheng, HW | 1 |
| Imai, K | 1 |
| Sun, X | 3 |
| Gao, Y | 3 |
| Ding, Z | 2 |
| Yang, Y | 4 |
| Sun, Q | 2 |
| Yang, X | 6 |
| Ge, W | 1 |
| Cheng, R | 2 |
| Fang, H | 1 |
| Gong, C | 1 |
| Fu, J | 1 |
| Bi, H | 1 |
| Cheng, Y | 1 |
| Liu, Y | 11 |
| Tang, Y | 2 |
| Niu, Y | 1 |
| Nie, Q | 1 |
| Dong, L | 1 |
| Liu, SF | 1 |
| Song, W | 1 |
| Wu, G | 1 |
| Song, D | 1 |
| Brown, TP | 1 |
| Bhattacharjee, P | 2 |
| Ramachandran, S | 2 |
| Sivaprakasam, S | 1 |
| Ristic, B | 1 |
| Sikder, MOF | 1 |
| Ganapathy, V | 3 |
| Schiffner, R | 1 |
| Bischoff, SJ | 1 |
| Lehmann, T | 1 |
| Irintchev, A | 1 |
| Nistor, M | 1 |
| Lemke, C | 1 |
| Schmidt, M | 1 |
| Sadeghi, M | 1 |
| Dogan, EM | 1 |
| Karlsson, C | 1 |
| Jansson, K | 3 |
| Seilitz, J | 1 |
| Skoog, P | 3 |
| Hörer, TM | 3 |
| Nilsson, KF | 3 |
| Roumes, H | 2 |
| Dumont, U | 2 |
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| Mazuel, L | 1 |
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| Hyacinthe, JN | 1 |
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| Beydoun, R | 1 |
| Yarmush, M | 1 |
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| Shan, B | 1 |
| Ai, Z | 1 |
| Zeng, S | 1 |
| Song, Y | 4 |
| Song, J | 3 |
| Zeng, Q | 1 |
| Liao, Z | 1 |
| Wang, T | 2 |
| Huang, C | 1 |
| Su, D | 1 |
| Yang, S | 5 |
| Cai, E | 1 |
| Lin, L | 3 |
| Zeng, P | 1 |
| Nie, B | 1 |
| Xu, F | 2 |
| Tian, Q | 1 |
| Wang, J | 6 |
| Prudhomme, T | 1 |
| Kervella, D | 1 |
| Ogbemudia, AE | 1 |
| Gauttier, V | 1 |
| Renaudin, K | 1 |
| Mesnard, B | 1 |
| Minault, D | 1 |
| Hervouet, J | 1 |
| Le Bas-Bernardet, S | 1 |
| Cantarovich, D | 1 |
| Karam, G | 1 |
| Blancho, G | 1 |
| Branchereau, J | 1 |
| Zhai, X | 1 |
| Li, L | 4 |
| Sun, Y | 5 |
| Zhang, X | 7 |
| Xue, Y | 1 |
| Lv, J | 2 |
| Li, S | 2 |
| Yan, W | 1 |
| Yin, S | 2 |
| Xiao, Z | 1 |
| Masjedi, A | 1 |
| Ahmadi, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Potential Role of Melatonin in Subjects With Relapsing Multiple Sclerosis (MS)[NCT03498131] | Early Phase 1 | 30 participants (Actual) | Interventional | 2018-05-09 | Completed | ||
| An Open-label, Multi-center, Phase 1b Study to Investigate the Safety and Tolerability of SLC-0111 (WBI-5111) in Combination With Gemcitabine in Metastatic Pancreatic Ductal Adenocarcinoma Subjects Positive for Carbonic Anhydrase IX[NCT03450018] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2019-01-10 | Recruiting | ||
| Prevention of Clostridium Difficile-associated Diarrhea by Daily Intake of Kefir[NCT02707198] | Phase 2 | 2 participants (Actual) | Interventional | 2015-11-30 | Terminated (stopped due to Study was not feasible to complete at study site) | ||
| Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies: A Non- Inferiority Randomized Clinical Trial[NCT05018130] | 44 participants (Anticipated) | Interventional | 2021-11-01 | Recruiting | |||
| The Infant MiND Study: An Examination of Infants' Microbiome, Nutrition, and Development Study.[NCT03229863] | 102 participants (Actual) | Interventional | 2017-04-18 | Active, not recruiting | |||
| Optimising the Duration of Cooling Therapy in Mild Neonatal Encephalopathy[NCT03409770] | 140 participants (Anticipated) | Interventional | 2019-10-10 | Active, not recruiting | |||
| A Phase II Pilot Study to Explore Treatment With Sodium Valproate in Adults With McArdle Disease (Glycogen Storage Disorder Type V, GSDV)[NCT03112889] | Phase 2 | 8 participants (Anticipated) | Interventional | 2015-01-31 | Completed | ||
| Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers[NCT05697406] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| A Phase 1 Ascending-dose Study to Assess the Safety and Tolerability and Imaging Potential of Hyperpolarized Pyruvate (13C) Injection in Subjects With Prostate Cancer[NCT01229618] | Phase 1 | 31 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Phase II Clinical Trial to Study the Feasibility and Safety of the Expanded Autologous Mesenchymal Stem Cells Use Derived From Adipose Tissue (ASC) for the Local Feminine Stress Urinary Incontinence[NCT01804153] | Phase 1/Phase 2 | 10 participants (Anticipated) | Interventional | 2012-09-30 | Recruiting | ||
| SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid[NCT03954210] | 200 participants (Anticipated) | Interventional | 2019-08-27 | Recruiting | |||
| Dietary Supplement N-acetylcysteine (NAC) as a Novel Complementary Medicine to Improve Cognitive Disfunction in Schizophrenia[NCT01885338] | Phase 1 | 26 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest[NCT06071910] | 20 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | |||
| The Global cVAD Study[NCT04136392] | 20,000 participants (Anticipated) | Observational [Patient Registry] | 2017-07-14 | Active, not recruiting | |||
| Determining the Factors That Affects Emergency Department Visits of Hyperglycemic Patients in 30 Days.[NCT04665128] | 120 participants (Anticipated) | Observational | 2020-12-15 | Recruiting | |||
| A National, Prospective, Randomized, Multicenter, Controlled Head-to-Head Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute in Filling of Contained Bone Defects[NCT00841152] | 120 participants (Actual) | Observational | 2009-03-31 | Completed | |||
| EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock[NCT04134624] | 215 participants (Actual) | Interventional | 2019-09-11 | Terminated (stopped due to Recruitment for this study was halted in February 2020 due to the COVID-19 pandemic. The study team was unable to continue enrollment due to decreased volumes (and the fact that COVID-19 mimics some of the signs and symptoms of severe sepsis)) | |||
| Clinical and Angiographic Evaluation of Paclitaxel Eluting, Non-Polymeric, Nanoporous Carbon-Carbon Coated, Cobalt-Chromium Stent[NCT00428662] | 200 participants | Interventional | 2007-01-31 | Recruiting | |||
| The Effect of Standardizing the Definition and Approach to a Clinically Significant Cardiopulmonary Event in Infants Less Than 30 Weeks on Length of Stay[NCT03414671] | 160 participants (Actual) | Observational | 2018-06-01 | Completed | |||
| [NCT01085149] | 20 participants (Anticipated) | Interventional | 2010-05-31 | Not yet recruiting | |||
| Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops: Prospective Double-Blind Randomized Study[NCT01850979] | Phase 4 | 24 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| Use of Hypertonic Versus Isotonic Solutions in Off Pump Coronary Artery Bypass Graft Surgery Targeting the Left Marginal Branch[NCT01463917] | Phase 4 | 20 participants (Anticipated) | Interventional | 2011-09-30 | Recruiting | ||
| Evaluation of Injectable Beta- Tricalcium Phosphate as an Occlusive Barrier Membrane in Treatment of Grade ii Furcation Involvement (Clinical and Radiographic Study)[NCT04443972] | 14 participants (Actual) | Interventional | 2018-04-12 | Completed | |||
| Peritoneal/Serum Lactate Ratio in Relaparotomy[NCT01161849] | 60 participants (Anticipated) | Observational | 2010-08-31 | Completed | |||
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
14 reviews available for lactic acid and Disease Models, Animal
| Article | Year |
|---|---|
Immunometabolism of infections.
Topics: Animals; Arenaviridae Infections; Caenorhabditis elegans; CD8-Positive T-Lymphocytes; Disease Models | 2020 |
Quantitative Assessment of Blood Lactate in Shock: Measure of Hypoxia or Beneficial Energy Source.
Topics: Animals; Critical Illness; Disease Models, Animal; Dogs; Humans; Hypoxia; Lactic Acid; Liver; Models | 2020 |
Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; Endophenotypes; Female; Humans; Hydrogen-Io | 2018 |
Models of attention-deficit hyperactivity disorder.
Topics: Animals; Astrocytes; Attention; Attention Deficit Disorder with Hyperactivity; Decision Making; Dise | 2019 |
Tolerance strategies employing antigen-coupled apoptotic cells and carboxylated PLG nanoparticles for the treatment of type 1 diabetes.
Topics: Animals; Apoptosis; Autoantigens; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Immune | 2012 |
Biomaterial scaffolds used for the regeneration of spinal cord injury (SCI).
Topics: Alginates; Animals; Apoptosis; Axons; Biocompatible Materials; Chitosan; Collagen; Disease Models, A | 2014 |
Magnetic resonance spectroscopy biomarkers in term perinatal asphyxial encephalopathy: from neuropathological correlates to future clinical applications.
Topics: Animals; Animals, Newborn; Aspartic Acid; Asphyxia Neonatorum; Biomarkers; Choline; Creatine; Diseas | 2014 |
[Investigation of Predisposition Biomarkers to Identify Risk Factors for Drug-induced Liver Injury in Humans: Analyses of Endogenous Metabolites in an Animal Model Mimicking Human Responders to APAP-induced Hepatotoxicity].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induc | 2015 |
Concerning the importance of changes in hemorheological parameters caused by acid-base and blood gas alterations in experimental surgical models.
Topics: Acid-Base Equilibrium; Animals; Disease Models, Animal; Erythrocyte Deformability; Gases; Hemorheolo | 2012 |
Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Disease Models, Animal; Dogs; Humans; Hypovolemia; Hypoxia | 2005 |
Poly-L-lactic acid: an overview.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Clinical Trials as Topic; Cosmetic Techniques | 2006 |
[Anxiety, panic and the hypothalamic-pituitary-adrenal axis].
Topics: Adrenocorticotropic Hormone; Animals; Carbon Dioxide; Disease Models, Animal; Humans; Hypothalamo-Hy | 2007 |
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
Psychobiology of anxiety and anxiety disorders.
Topics: Animals; Anxiety; Anxiety Disorders; Blood Platelets; Caffeine; Carbolines; Carbon Dioxide; Cats; Di | 1985 |
6 trials available for lactic acid and Disease Models, Animal
| Article | Year |
|---|---|
Metformin induces lactate accumulation and accelerates renal cyst progression in Pkd1-deficient mice.
Topics: Animals; Cysts; Disease Models, Animal; Female; Kidney; Lactic Acid; Male; Metformin; Mice; Mice, Tr | 2022 |
Improved resuscitation minimizes respiratory dysfunction and blunts interleukin-6 and nuclear factor-kappa B activation after traumatic hemorrhage.
Topics: Airway Resistance; Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Cardiopulmonary Resuscitat | 2002 |
Treatment of septic shock with a protease inhibitor in a canine model: a prospective, randomized, controlled trial.
Topics: Adult; Animals; Blood Glucose; Colony Count, Microbial; Disease Models, Animal; Dogs; Dose-Response | 1993 |
Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transpla | 1999 |
[Evaluation of the biocompatibility of grafts for bone defects].
Topics: Alveolar Ridge Augmentation; Alveolectomy; Alveoloplasty; Animals; Biocompatible Materials; Bone Res | 1999 |
Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study.
Topics: Animals; Antineoplastic Agents; Arginine; Cachexia; Diet; Dietary Supplements; Disease Models, Anima | 2000 |
1117 other studies available for lactic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Astrocyte-neuron lactate transport in the ACC contributes to the occurrence of long-lasting inflammatory pain in male mice.
Topics: Animals; Arabinose; Astrocytes; Cell Communication; Chronic Pain; Disease Models, Animal; Freund's A | 2021 |
Predicting intestinal viability by consecutive photoacoustic monitoring of oxygenation recovery after reperfusion in acute mesenteric ischemia in rats.
Topics: Animals; Biomarkers; Diagnostic Imaging; Disease Models, Animal; Ileum; Intestines; Lactic Acid; Mes | 2021 |
Lactic Acid-Producing Probiotic
Topics: Animals; Caspase 1; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Dysbiosis; Fatty | 2021 |
Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep.
Topics: Adipose Tissue; Animals; Disease Models, Animal; Female; Fetal Growth Retardation; Fetal Hypoxia; Fe | 2022 |
A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs.
Topics: Adipose Tissue; Amino Acids; Animals; Bread; Dietary Fiber; Dietary Supplements; Disease Models, Ani | 2021 |
Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.
Topics: Abortion, Spontaneous; Adult; Animals; Cell Differentiation; Disease Models, Animal; Female; Humans; | 2022 |
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea | 2022 |
Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model.
Topics: Animals; Blood Glucose; Cadmium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease | 2022 |
Surface Modification of Nanoparticles Enhances Drug Delivery to the Brain and Improves Survival in a Glioblastoma Multiforme Murine Model.
Topics: Animals; Brain; Cell Line, Tumor; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Glio | 2022 |
A Modified Arrestin1 Increases Lactate Production in the Retina and Slows Retinal Degeneration.
Topics: Animals; Arrestins; Disease Models, Animal; Electroretinography; Glucose; Lactic Acid; Mice; Mice, I | 2022 |
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments.
Topics: Animals; Biomarkers, Tumor; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Fl | 2022 |
Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model.
Topics: Animals; Area Under Curve; Carbon Dioxide; Disease Models, Animal; Ischemia; Lactic Acid; Microdialy | 2022 |
Alteration in glucose metabolism in the brain associated with tamoxifen treatment: Study in postmenopausal animal model.
Topics: Animals; Disease Models, Animal; Female; Glucose; Hippocampus; Humans; Hyperglycemia; Lactic Acid; P | 2022 |
PDK4 Inhibition Ameliorates Melatonin Therapy by Modulating Cerebral Metabolism and Remyelination in an EAE Demyelinating Mouse Model of Multiple Sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Lactic Acid; Melatonin | 2022 |
An exercise-inducible metabolite that suppresses feeding and obesity.
Topics: Adiposity; Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Energy M | 2022 |
Novel microparticulate Zika vaccine induces a significant immune response in a preclinical murine model after intramuscular administration.
Topics: Adjuvants, Immunologic; Animals; Disease Models, Animal; Immunity; Lactic Acid; Mice; Polyglycolic A | 2022 |
Swim Training Affects on Muscle Lactate Metabolism, Nicotinamide Adenine Dinucleotides Concentration, and the Activity of NADH Shuttle Enzymes in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Adenine; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Lactic Acid; Malate Dehydro | 2022 |
Lactate-driven macrophage polarization in the inflammatory microenvironment alleviates intestinal inflammation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; L | 2022 |
Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Proliferation; Cholan | 2023 |
Methylene Blue to Neonatal Septic Shock treatment in neonate pigs
Topics: Animals; Disease Models, Animal; Lactic Acid; Male; Methylene Blue; Neonatal Sepsis; Sepsis; Shock, | 2022 |
Methylene Blue to Neonatal Septic Shock treatment in neonate pigs
Topics: Animals; Disease Models, Animal; Lactic Acid; Male; Methylene Blue; Neonatal Sepsis; Sepsis; Shock, | 2022 |
Methylene Blue to Neonatal Septic Shock treatment in neonate pigs
Topics: Animals; Disease Models, Animal; Lactic Acid; Male; Methylene Blue; Neonatal Sepsis; Sepsis; Shock, | 2022 |
Methylene Blue to Neonatal Septic Shock treatment in neonate pigs
Topics: Animals; Disease Models, Animal; Lactic Acid; Male; Methylene Blue; Neonatal Sepsis; Sepsis; Shock, | 2022 |
Study on an Animal Model of Seawater Immersion Injury Following Hemorrhagic Shock.
Topics: Animals; Disease Models, Animal; Hemorrhage; Lactic Acid; Male; Rats; Rats, Sprague-Dawley; Resuscit | 2023 |
Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.
Topics: Animals; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Hemorrhage; Lactic Acid | 2023 |
Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cullin Proteins; Disease Models, Animal; Female; Glyc | 2023 |
MILD THERAPEUTIC HYPOTHERMIA REDUCES ISCHEMIA-REPERFUSION INJURY AFTER ZONE 1 REBOA IN A SWINE HEMORRHAGIC SHOCK MODEL.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Hypothermia; Hypothermia, Induced; Lactic | 2023 |
Pre-stroke exercise does not reduce atrophy in healthy young adult mice.
Topics: Animals; Atrophy; Brain; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Lactic | 2023 |
Aqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment.
Topics: alpha-MSH; Animals; Body Weight; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; | 2023 |
Gut microbial change after administration of
Topics: Animals; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Lactic Acid; Lacticaseibaci | 2023 |
Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Heart Arrest; Lactic Acid; Mice; Myocytes, | 2023 |
High-sensitivity deuterium metabolic MRI differentiates acute pancreatitis from pancreatic cancers in murine models.
Topics: Acute Disease; Animals; Deuterium; Disease Models, Animal; Humans; Lactic Acid; Magnetic Resonance I | 2023 |
Myofascial pain and treatment: Editorial.
Topics: Acupuncture Therapy; Animals; Chronic Pain; Disease Models, Animal; Dry Needling; Female; Glucose; G | 2019 |
Lactate up-regulates the expression of PD-L1 in kidney and causes immunosuppression in septic Acute Renal Injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; B7-H1 Antigen; Disease Models, Animal; Epithelial Cells; Im | 2021 |
Increased lactic acid content associated with extracellular matrix depletion in a porcine disc degeneration induced by superficial annular lesion.
Topics: Animals; Disease Models, Animal; Extracellular Matrix; Female; Intervertebral Disc; Intervertebral D | 2019 |
Identification of a new
Topics: Alternative Splicing; Animals; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferat | 2019 |
CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Disease Progressi | 2019 |
Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease.
Topics: Adrenal Cortex Hormones; Adult; Animals; Biodiversity; Butyrates; Disease Models, Animal; DNA, Bacte | 2020 |
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Topics: Animals; Aristolochic Acids; Chromatography, High Pressure Liquid; Disease Models, Animal; Female; F | 2020 |
Soluble beta-glucan salecan improves vaginal infection of Candida albicans in mice.
Topics: Animals; Antifungal Agents; beta-Glucans; Candida albicans; Candidiasis, Vulvovaginal; Colony Count, | 2020 |
Evaluation of 2 Rat Models for Sepsis Developed by Improved Cecal Ligation/Puncture or Feces Intraperitoneal-Injection.
Topics: Animals; Cecum; Disease Models, Animal; Feces; Injections, Intraperitoneal; Interleukin-6; Intestine | 2020 |
Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch.
Topics: Animals; Asthma; Bronchoconstrictor Agents; Cells, Cultured; Disease Models, Animal; Female; Glycoly | 2020 |
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment.
Topics: Animals; Antigen-Presenting Cells; Breast Neoplasms; Cell Proliferation; Cyclic AMP; Dendritic Cells | 2020 |
Altered Cerebral Blood Flow and Potential Neuroprotective Effect of Human Relaxin-2 (Serelaxin) During Hypoxia or Severe Hypovolemia in a Sheep Model.
Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Disease Models, Animal; Hypovolemia; Hypoxi | 2020 |
Total resuscitative endovascular balloon occlusion of the aorta causes inflammatory activation and organ damage within 30 minutes of occlusion in normovolemic pigs.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Female; Hemodyna | 2020 |
Neuroprotective role of lactate in rat neonatal hypoxia-ischemia.
Topics: Animals; Disease Models, Animal; Female; Humans; Hypoxia-Ischemia, Brain; Lactic Acid; Rats; Rats, W | 2021 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Plasma Metabolomic Changes in Mice With Time-restricted Feeding-attenuated Spontaneous Metastasis of Lewis Lung Carcinoma.
Topics: alpha-Tocopherol; Animals; Carcinoma, Lewis Lung; Cholestanol; Cholesterol; Diet, High-Fat; Disease | 2020 |
Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets.
Topics: Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain; Diffusion Magnetic Resonance Imaging; D | 2021 |
Stress gates an astrocytic energy reservoir to impair synaptic plasticity.
Topics: Adaptation, Psychological; Animals; Astrocytes; Disease Models, Animal; Energy Metabolism; Female; G | 2020 |
Adenosine, Lidocaine, and Magnesium Support a High Flow, Hypotensive, Vasodilatory State With Improved Oxygen Delivery and Cerebral Protection in a Pig Model of Noncompressible Hemorrhage.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Disease Models, Animal; Drug Administration Schedule; Dr | 2020 |
Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Diabetes Mellitus, Type 2; Diabetic Retinopat | 2020 |
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content.
Topics: Animals; Bicarbonates; Cytokines; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; L | 2020 |
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Gastrointestinal | 2020 |
Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Emodin; Lactic Acid; Magnetic Resonance Spectr | 2020 |
Total Pancreatectomy and Pancreatic Allotransplant in a Porcine Experimental Model.
Topics: Animals; Biomarkers; Blood Glucose; Blood Platelets; C-Peptide; Diabetes Mellitus, Type 1; Disease M | 2020 |
L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Lactic Acid; Male; Neuronal Plast | 2020 |
Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy.
Topics: Adenosine A2 Receptor Antagonists; Animals; Breast Neoplasms; Cancer Vaccines; CD8-Positive T-Lympho | 2020 |
In vivo [U-
Topics: Animals; Blood Glucose; Carbon Isotopes; Citric Acid Cycle; Disease Models, Animal; Energy Metabolis | 2020 |
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Disease Models, Animal; Endothelium, Vascular; Female; Huma | 2020 |
Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Alzheimer Disease; Animals; Anticonvulsants; Atropine; Dis | 2020 |
Pulmonary pyruvate metabolism as an index of inflammation and injury in a rat model of acute respiratory distress syndrome.
Topics: Animals; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Intercellular Adhesion M | 2020 |
Temporally Altered miRNA Expression in a Piglet Model of Hypoxic Ischemic Brain Injury.
Topics: Animals; Animals, Newborn; Biomarkers; Bone Morphogenetic Protein Receptors, Type II; Brain; Brain I | 2020 |
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Disease | 2021 |
Dietary Fermented Soy Extract and Oligo-Lactic Acid Alleviate Chronic Kidney Disease in Mice via Inhibition of Inflammation and Modulation of Gut Microbiota.
Topics: Adenine; Animals; Biomarkers; Cecum; Clostridium; Cystatin C; Cytokines; Dietary Supplements; Diseas | 2020 |
Enhancing effect of fumaric acid on transdermal penetration of loxoprofen sodium.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Mo | 2020 |
Effect of ventilation rate on recovery after cardiac arrest in a pediatric animal model.
Topics: Animals; Arterial Pressure; Asphyxia; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Lactic A | 2020 |
Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Disease Models, Animal; Female; Hypoxia; Hypoxia-I | 2020 |
Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer.
Topics: Animals; Disease Models, Animal; Humans; Immunosuppression Therapy; Lactic Acid; Mice; Myeloid-Deriv | 2020 |
Glucagon-like peptide 2 attenuates intestinal mucosal barrier injury through the MLCK/pMLC signaling pathway in a piglet model.
Topics: Amine Oxidase (Copper-Containing); Animals; Cell Line; Cell Shape; Cell Survival; Cytokines; Disease | 2021 |
Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels.
Topics: Animals; Butyric Acid; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Fe | 2020 |
SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Survival; Cell Transf | 2020 |
[Neuroprotective role of lactate in neonatal hypoxia-ischemia].
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Energy Metabolism; Humans; Hypoxia-Ischemi | 2020 |
Organic Selenium Reaches the Central Nervous System and Downmodulates Local Inflammation: A Complementary Therapy for Multiple Sclerosis?
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Disease Models, Animal; Encephalomyelitis | 2020 |
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model.
Topics: Acetates; Animals; Azoxymethane; Bifidobacterium; Blood Glucose; Body Weight; Butyrates; Carcinogene | 2021 |
SIRT3 (Sirtuin-3) Prevents Ang II (Angiotensin II)-Induced Macrophage Metabolic Switch Improving Perivascular Adipose Tissue Function.
Topics: Acetylation; Adipose Tissue, Brown; Angiotensin II; Animals; Cell Plasticity; Disease Models, Animal | 2021 |
Exhaustive endurance exercise activates brain glycogen breakdown and lactate production more than insulin-induced hypoglycemia.
Topics: Animals; Blood Glucose; Brain; Cyclic AMP; Disease Models, Animal; Glycogen; Hypoglycemia; Insulin; | 2021 |
Pathophysiologic Mechanisms of Hypothermia-Induced Pancreatic Injury in a Rat Model of Body Surface Cooling.
Topics: Amylases; Animals; Apoptosis; Biomarkers; Cytokines; Disease Models, Animal; Hypothermia, Induced; I | 2021 |
Evaluation of the nephrotoxicity and safety of low-dose aristolochic acid, extending to the use of Xixin (Asurum), by determination of methylglyoxal and d-lactate.
Topics: Animals; Aristolochic Acids; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fibros | 2021 |
Bosutinib reduces endothelial permeability and organ failure in a rat polytrauma transfusion model.
Topics: Aniline Compounds; Animals; Blood Transfusion; Disease Models, Animal; Endothelium, Vascular; Lactic | 2021 |
Time-dependent influence of infliximab on hemodynamic responses and cardiac injuries of isoproterenol-induced myocardial infarction in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Disease Models, Animal; Heart Injuries | 2021 |
Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice.
Topics: Animals; Dermatitis; Disease Models, Animal; Female; Gastrointestinal Microbiome; Imiquimod; Lactic | 2021 |
Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats.
Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Electromagnetic Fields; Energy | 2021 |
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression.
Topics: Aminopyridines; Animals; Blotting, Western; Cell Count; Cell Line; Cell Movement; Cell Proliferation | 2021 |
Extracellular vesicles derived from cardiosphere-derived cells as a potential antishock therapeutic.
Topics: Animals; Blood Glucose; Creatinine; Disease Models, Animal; Extracellular Vesicles; Flow Cytometry; | 2021 |
Deuterium MRSI characterizations of glucose metabolism in orthotopic pancreatic cancer mouse models.
Topics: Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deuterium; Disease Models, | 2021 |
Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney.
Topics: Alanine; Animals; Bicarbonates; Disease Models, Animal; Enzyme Activation; Glucose; Glycolysis; Hema | 2021 |
Combatting ischemia reperfusion injury from resuscitative endovascular balloon occlusion of the aorta using adenosine, lidocaine and magnesium: A pilot study.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Aorta; Balloon Occlusion; Disease Models, Animal; Drug | 2021 |
Enhanced Glycolytic Metabolism Contributes to Cardiac Dysfunction in Polymicrobial Sepsis.
Topics: Animals; Cardiomyopathies; Cytokines; Deoxyglucose; Disease Models, Animal; Glycolysis; Heart; Hexok | 2017 |
Association between Brain and Kidney Near-Infrared Spectroscopy and Early Postresuscitation Mortality in Asphyxiated Newborn Piglets.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Brain; Cardiac Output; Cardiopulmona | 2017 |
Effect of Training at Lactate Threshold Intensity on Maximal Time to Exhaustion, Depression and Anxiety Behaviour of Spontaneously Hypertensive Rats after Kainate-Induced Status Epilepticus.
Topics: Animals; Anxiety; Behavior, Animal; Comorbidity; Depression; Disease Models, Animal; Essential Hyper | 2017 |
PLGA-based dual targeted nanoparticles enhance miRNA transfection efficiency in hepatic carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Models, Animal; Dynamic Light Scatteri | 2017 |
Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Proliferation; Curcumin; Cytokines; Delayed | 2018 |
Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest.
Topics: Animals; Antioxidants; Biomarkers; Brain; Cardiopulmonary Bypass; Circulatory Arrest, Deep Hypotherm | 2017 |
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.
Topics: Animals; Astrocytes; Cell Communication; Cerebral Cortex; Coculture Techniques; CREB-Binding Protein | 2017 |
Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43.
Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Cell Proliferation; Connexin 43; Di | 2017 |
Metabolic Characterization of Myocardial Infarction Using GC-MS-Based Tissue Metabolomics.
Topics: Animals; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutamine; Lac | 2017 |
ASIATIC ACID INFLUENCES GLUCOSE HOMEOSTASIS IN
Topics: Animals; Disease Models, Animal; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Lactic Acid; | 2016 |
Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis.
Topics: Animals; Blood Gas Analysis; C-Reactive Protein; Cohort Studies; Disease Models, Animal; Hemodynamic | 2017 |
Effects of annulus defects and implantation of poly(lactic-co-glycolic acid) (PLGA)/fibrin gel scaffolds on nerves ingrowth in a rabbit model of annular injury disc degeneration.
Topics: Animals; Disease Models, Animal; Fibrin; Gels; Intervertebral Disc Degeneration; Lactic Acid; Polygl | 2017 |
Investigation of the pathophysiology of cardiopulmonary bypass using rodent extracorporeal life support model.
Topics: Animals; Asphyxia; Biomarkers; Cardiopulmonary Bypass; Carrier Proteins; Disease Models, Animal; Ext | 2017 |
Comparison of early sequential hypothermia and delayed hypothermia on neurological function after resuscitation in a swine model.
Topics: Animals; Brain; Cardiopulmonary Resuscitation; Disease Models, Animal; Dopamine; Frontal Lobe; Gluco | 2017 |
Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Coculture Techniq | 2017 |
Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats.
Topics: Animals; Blindness; Delayed-Action Preparations; Disease Models, Animal; Electroretinography; Lactic | 2017 |
The effects of acute renal denervation on kidney perfusion and metabolism in experimental septic shock.
Topics: Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Female; Kidney Cortex; Lactic Acid | 2017 |
Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.
Topics: A549 Cells; Acute Lung Injury; Alveolar Epithelial Cells; Animals; Anti-Inflammatory Agents, Non-Ste | 2017 |
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Cell Line, Tumor; Disease Models, Animal; Energy Metabo | 2017 |
Exercise prior to, but not concomitant with, stress reverses stress-induced delayed skin wound healing.
Topics: Animals; Behavior, Animal; Cell Differentiation; Collagen; Cytokines; Disease Models, Animal; Granul | 2017 |
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression.
Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease | 2017 |
Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury.
Topics: Animals; Cell Differentiation; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; D | 2017 |
Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters.
Topics: 3-Hydroxybutyric Acid; Animals; Astrocytes; Brain; Diet, Ketogenic; Disease Models, Animal; Epilepsy | 2017 |
Targeted delivery of Cyclosporine A by polymeric nanocarriers improves the therapy of inflammatory bowel disease in a relevant mouse model.
Topics: Administration, Oral; Animals; Biological Availability; Colon; Cyclosporine; Disease Models, Animal; | 2017 |
The Metabolopathy of Tissue Injury, Hemorrhagic Shock, and Resuscitation in a Rat Model.
Topics: Animals; Disease Models, Animal; Glycolysis; Hyperglycemia; Lactic Acid; Male; Metabolomics; Rats; R | 2018 |
Hyperpolarized
Topics: Animals; Carbon Isotopes; Cuprizone; Disease Models, Animal; Female; Lactic Acid; Magnetic Resonance | 2017 |
Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide.
Topics: Animals; Anti-Infective Agents; Chitosan; Disease Models, Animal; Disease Progression; Lactic Acid; | 2018 |
Enhancement of ocular efficacy of aceclofenac using biodegradable PLGA nanoparticles: formulation and characterization.
Topics: Administration, Ophthalmic; Animals; Arachidonic Acid; Calorimetry, Differential Scanning; Chemistry | 2017 |
Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2017 |
Evaluation of the Toxicity of Intravitreally Injected PLGA Microspheres and Rods in Monkeys and Rabbits: Effects of Depot Size on Inflammatory Response.
Topics: Animals; Biocompatible Materials; Cytokines; Disease Models, Animal; Drug Delivery Systems; Foreign- | 2017 |
Diet-induced obesity accelerates blood lactate accumulation of rats in response to incremental exercise to maximum.
Topics: Adaptation, Physiological; Animals; Biomarkers; Diet, High-Fat; Disease Models, Animal; Energy Metab | 2017 |
Polymeric nanoparticles of siRNA prepared by a double-emulsion solvent-diffusion technique: Physicochemical properties, toxicity, biodistribution and efficacy in a mammary carcinoma mice model.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Diffusion; Disease Models, Animal; Emulsi | 2017 |
Pretreatment with fish oil attenuates heart ischaemia consequences in rats.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dietary Supplements; Disease Models, Animal; | 2017 |
Metabolic assessment of a migraine model using relaxation-enhanced
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; Lactic Acid; Magnetic Resonance Imaging; Ma | 2018 |
Preparation and investigation of P28GST-loaded PLGA microparticles for immunomodulation of experimental colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Delivery Systems; Drug Liberation; Female; Glutathion | 2017 |
Therapeutic treatment with scFv-PLGA nanoparticles decreases pulmonary fungal load in a murine model of paracoccidioidomycosis.
Topics: Animals; Antibodies, Fungal; Antigens, Fungal; Colony Count, Microbial; Cytokines; Dendritic Cells; | 2018 |
A pro-angiogenic degradable Mg-poly(lactic-co-glycolic acid) implant combined with rhbFGF in a rat limb ischemia model.
Topics: Animals; Biodegradable Plastics; Disease Models, Animal; Drug Implants; Fibroblast Growth Factor 2; | 2017 |
Lactate Metabolism in Human Lung Tumors.
Topics: Animals; Blood Chemical Analysis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Citric Acid Cycl | 2017 |
Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.
Topics: Animals; Astrocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expressi | 2017 |
Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells.
Topics: Animals; Apoptosis; Biomarkers; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Ce | 2017 |
The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Topics: Animals; Bone Cements; Bone Density; Bone Diseases, Metabolic; Bone Regeneration; Compressive Streng | 2018 |
High-fat diet reduces the hippocampal content level of lactate which is correlated with the expression of glial glutamate transporters.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Ami | 2018 |
Systemic Inflammatory Response and Multiple Organ Dysfunctions Following Crush Injury: a New Experimental Model in Rabbits.
Topics: Animals; Biomarkers; Body Temperature Regulation; Body Weight; Carbon Dioxide; Crush Injuries; Cytok | 2018 |
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph | 2018 |
IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Cells, Cultured; Cohort Studies; Disease Models, Animal | 2018 |
All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, Animal; Gas Chromatograph | 2018 |
Cryptdin-2 predicts intestinal injury during heatstroke in mice.
Topics: alpha-Defensins; Amine Oxidase (Copper-Containing); Animals; Defensins; Disease Models, Animal; Gene | 2018 |
Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Lactic Acid; Rabbits; Random Allocation | 2017 |
Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered nano-shielding of pancreatic islets to enhance xenograft survival in a diabetic mouse model.
Topics: Animals; Coated Materials, Biocompatible; Collagen; Diabetes Mellitus, Experimental; Dihydroxyphenyl | 2018 |
Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord.
Topics: Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Demyelinating Diseases; Disease Models, | 2018 |
Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.
Topics: Abietanes; Animals; Blood Glucose; Blood Urea Nitrogen; Disease Models, Animal; Dose-Response Relati | 2017 |
Online
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Disease Models, Animal; Female; Glioma; Lactic Acid | 2018 |
Intra-abdominal infection combined with intra-abdominal hypertension aggravates the intestinal mucosal barrier dysfunction.
Topics: Amine Oxidase (Copper-Containing); Animals; Dextrans; Disease Models, Animal; Fluorescein-5-isothioc | 2018 |
A fatal and metabolic experimental hemorrhagic shock in immature swine.
Topics: Animals; Biomarkers; Control Groups; Disease Models, Animal; Endpoint Determination; Hemodynamics; H | 2017 |
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice.
Topics: Anesthetics, Local; Animals; Bupivacaine; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Lac | 2018 |
GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Female; Homeostasis; Lactic Acid; Macrophages; | 2018 |
Buckberg's blood cardioplegia for protection of adult and senile myocardium in a rat in vitro model of acute myocardial infarction.
Topics: Analysis of Variance; Animals; Aorta; Cardioplegic Solutions; Constriction; Coronary Vessels; Diseas | 2018 |
Placental physiology monitored by hyperpolarized dynamic
Topics: Animals; Bicarbonates; Carbon Isotopes; Disease Models, Animal; Female; Humans; Lactic Acid; Magneti | 2018 |
TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells.
Topics: ADAMTS5 Protein; Aerobiosis; Animals; Cell Hypoxia; Disease Models, Animal; Gene Expression Regulati | 2018 |
Blood cardioplegia for cardiac surgery in acute myocardial infarction: rat experiments with two widely used solutions.
Topics: Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Disease Models, Animal; Heart Arrest, | 2018 |
Target and untargeted GC-MS based metabolomic study of mouse optic nerve and its potential in the study of neurological visual diseases.
Topics: Animals; Biomarkers; Disease Models, Animal; Eye; Female; Gas Chromatography-Mass Spectrometry; Lact | 2018 |
Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.
Topics: Acute Lung Injury; Animals; Biomarkers; Carbon Isotopes; Disease Models, Animal; Gene Expression; Hu | 2018 |
Cerebral Metabolic Changes Related to Oxidative Metabolism in a Model of Bacterial Meningitis Induced by Lipopolysaccharide.
Topics: Animals; Cerebrum; Disease Models, Animal; Female; Lactic Acid; Lipopolysaccharides; Meningitis, Bac | 2018 |
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Brain Mapping; Carbon Radioisotopes; Contrast Media | 2018 |
Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.
Topics: Animals; Cell Line; Corpus Striatum; Disease Models, Animal; Female; Glucose Transporter Type 3; Hum | 2018 |
Activated Α7nachr Improves Postoperative Cognitive Dysfunction and Intestinal Injury Induced by Cardiopulmonary Bypass in Rats: Inhibition of the Proinflammatory Response Through the Th17 Immune Response.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; bcl-2-Associated X Protein; Brain; Cardiopulmonary | 2018 |
Differences in peritoneal response after exposure to low-GDP bicarbonate/lactate-buffered dialysis solution compared to conventional dialysis solution in a uremic mouse model.
Topics: Actins; Animals; Bicarbonates; Buffers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chemokine | 2018 |
Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo.
Topics: Animals; Disease Models, Animal; Disease Progression; Heterografts; Humans; Image Enhancement; Lacti | 2019 |
Sirolimus-coated, poly(L-lactic acid)-modified polypropylene mesh with minimal intra-peritoneal adhesion formation in a rat model.
Topics: Abdominal Wall; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Female; Lactic Acid; Lapa | 2018 |
Development of fluorometholone-loaded PLGA nanoparticles for treatment of inflammatory disorders of anterior and posterior segments of the eye.
Topics: Administration, Ophthalmic; Animals; Anti-Inflammatory Agents; Biological Availability; Chickens; Ch | 2018 |
Biospectroscopic Imaging Provides Evidence of Hippocampal Zn Deficiency and Decreased Lipid Unsaturation in an Accelerated Aging Mouse Model.
Topics: Aging; Animals; CA3 Region, Hippocampal; Corpus Callosum; Dementia; Disease Models, Animal; Fatty Ac | 2018 |
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Dextran Sulfate; Diet; Dis | 2019 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Gene Ex | 2018 |
Effect of electroacupuncture at ST36 on the intestinal mucosal mechanical barrier and expression of occludin in a rat model of sepsis.
Topics: Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Humans; Intestinal Mucosa; | 2018 |
Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction.
Topics: Acetic Acid; Alanine; Analysis of Variance; Animals; Biomarkers; Citric Acid; Creatinine; Disease Mo | 2018 |
Lactic Acid Upregulates VEGF Expression in Macrophages and Facilitates Choroidal Neovascularization.
Topics: Animals; Cells, Cultured; Choroid; Choroidal Neovascularization; Disease Models, Animal; Enzyme-Link | 2018 |
Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model.
Topics: Acetylcholine; Animals; Celiac Artery; Disease Models, Animal; Endothelin A Receptor Antagonists; En | 2018 |
Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tum | 2018 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H | 2018 |
Endovascular variable aortic control (EVAC) versus resuscitative endovascular balloon occlusion of the aorta (REBOA) in a swine model of hemorrhage and ischemia reperfusion injury.
Topics: Animals; Aorta; Balloon Occlusion; Disease Models, Animal; Endovascular Procedures; Female; Hemodyna | 2018 |
Aortic branch vessel flow during resuscitative endovascular balloon occlusion of the aorta.
Topics: Animals; Aorta; Arteries; Balloon Occlusion; Blood Flow Velocity; Disease Models, Animal; Endovascul | 2019 |
Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2019 |
Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Lactic Acid; Mice; | 2018 |
Biodegradable Nanoparticles Containing Mechanism Based Peptide Inhibitors Reduce Polyglutamine Aggregation in Cell Models and Alleviate Motor Symptoms in a Drosophila Model of Huntington's Disease.
Topics: Animals; Blood-Brain Barrier; Brain; Cell Aggregation; Disease Models, Animal; Drosophila; Huntingto | 2019 |
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions.
Topics: Acriflavine; Active Transport, Cell Nucleus; Animals; Anti-Infective Agents, Local; Basic Helix-Loop | 2019 |
Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet.
Topics: Animals; Blood-Brain Barrier; Brain; Carbon Isotopes; Cognitive Dysfunction; Diet, High-Fat; Disease | 2018 |
Carvedilol prevents counterregulatory failure and impaired hypoglycaemia awareness in non-diabetic recurrently hypoglycaemic rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Blood Glucose; Body Weight; Carvedilol; Catheteriza | 2019 |
Extracorporeal potassium binding for the management of hyperkalemia in an anephric model of crush injury.
Topics: Animals; Crush Injuries; Disease Models, Animal; Extracorporeal Circulation; Female; Hyperkalemia; K | 2019 |
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.
Topics: Animals; Antidepressive Agents; Anxiety; Avoidance Learning; Behavior, Animal; Benzamides; Depressio | 2019 |
Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy.
Topics: Alleles; Animals; Biomarkers; Brain; Disease Models, Animal; Disease Progression; Electron Transport | 2019 |
Hyperpolarized MRI for Studying Tumor Metabolism.
Topics: Animals; Biomarkers; Data Analysis; Disease Models, Animal; Energy Metabolism; Humans; Kinetics; Lac | 2019 |
Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.
Topics: Animals; Axons; Disease Models, Animal; Evoked Potentials; Glucose; Hydrogen-Ion Concentration; Hypo | 2019 |
Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis.
Topics: Animals; Aorta; Aorta, Thoracic; Asparagine; Atherosclerosis; Biomarkers; Cholesterol; Cholesterol, | 2019 |
Cardiopulmonary resuscitation ameliorates myocardial mitochondrial dysfunction in a cardiac arrest rat model.
Topics: Animals; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardiography; Energy Metaboli | 2020 |
MicroRNA-140 inhibits skeletal muscle glycolysis and atrophy in endotoxin-induced sepsis in mice via the WNT signaling pathway.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; beta Catenin; Cells, Cultured; Cytokines; Disease | 2019 |
Dexmedetomidine attenuates myocardial ischemia/reperfusion injury through regulating lactate signaling cascade in mice.
Topics: Animals; Caspase 3; Caspase 9; Coronary Vessels; Cytochromes c; Dexmedetomidine; Disease Models, Ani | 2019 |
A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation.
Topics: Animals; Disease Models, Animal; Electrocardiography; Heart Transplantation; Hydrogen-Ion Concentrat | 2019 |
Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.
Topics: Animals; Biomarkers; Cardiac Output; Cardiomyopathies; Cytokines; Disease Models, Animal; Disease Pr | 2019 |
Gender differences in response to abdominal compartment syndrome in rats.
Topics: Abdomen; Adult; Animals; Arterial Pressure; Disease Models, Animal; Female; Humans; Intra-Abdominal | 2019 |
High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypoxia; Ki | 2019 |
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cluster Analysis; Colonic Neoplasms; Disease Models, Anim | 2013 |
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models | 2013 |
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.
Topics: Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Anim | 2013 |
Physiologic tolerance of descending thoracic aortic balloon occlusion in a swine model of hemorrhagic shock.
Topics: Animals; Aorta, Thoracic; Balloon Occlusion; Blood Pressure; Blood Transfusion; Disease Models, Anim | 2013 |
Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Amyloid beta-Peptides; Animals; Behavior, Ani | 2013 |
Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices.
Topics: Animals; Carbon Dioxide; Cerebellum; Disease Models, Animal; Female; Glucose; Hypothyroidism; Lactat | 2013 |
Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency.
Topics: Administration, Inhalation; Alprostadil; Animals; Delayed-Action Preparations; Disease Models, Anima | 2013 |
Target blood pressure for hypotensive resuscitation.
Topics: Animals; Cytokines; Disease Models, Animal; Fluid Therapy; Hematocrit; Hypotension; Isotonic Solutio | 2013 |
Effect of exercise associated with stem cell transplantation on ventricular function in rats after acute myocardial infarction.
Topics: Analysis of Variance; Animals; Bone Marrow Transplantation; Collagen; Disease Models, Animal; Lactic | 2012 |
Cavo-pulmonary anastomosis associated with left ventricular in comparison with biventricular circulatory support in acute heart failure.
Topics: Animals; Cytokines; Disease Models, Animal; Heart Bypass, Right; Heart Failure; Heart Ventricles; He | 2012 |
Biodegradation and heart retention of polymeric microparticles in a rat model of myocardial ischemia.
Topics: Animals; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Emulsions; Feasibility Studie | 2013 |
A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure.
Topics: Animals; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Cardiovascula | 2013 |
Protective effect of a mixture of kefir-isolated lactic acid bacteria and yeasts in a hamster model of Clostridium difficile infection.
Topics: Administration, Oral; Animals; Bacterial Toxins; Cecum; Clostridioides difficile; Cricetinae; Cultur | 2013 |
A decoy oligonucleotide to NF-κB delivered through inhalable particles prevents LPS-induced rat airway inflammation.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Interleukin-6; Lactic Acid; Lipopolysac | 2013 |
Terlipressin with limited fluid resuscitation in a swine model of hemorrhage.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Fluid Therapy; Heart Rate; Hemorrhage; Lactic Ac | 2013 |
Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity.
Topics: 1-Naphthylamine; Animals; Apoptosis Regulatory Proteins; Boronic Acids; C-Reactive Protein; Cytokine | 2013 |
The biological performance of injectable calcium phosphate/PLGA cement in osteoporotic rats.
Topics: Animals; Bone Cements; Bone Regeneration; Bone Substitutes; Calcium Phosphates; Disease Models, Anim | 2013 |
[Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect].
Topics: Adenosine Triphosphate; Age Factors; Animals; Cell Membrane; Citrate (si)-Synthase; Disease Models, | 2013 |
Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia.
Topics: Animals; Cell Proliferation; Coronary Vessels; Disease Models, Animal; Female; Human Umbilical Vein | 2013 |
Multi-ligand poly(L-lactic-co-glycolic acid) nanoparticles inhibit activation of endothelial cells.
Topics: Animals; Anti-Inflammatory Agents; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis | 2013 |
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diabetes Mellitus, Ex | 2013 |
Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies.
Topics: Animals; Antioxidants; Cell Respiration; Disease Models, Animal; Drosophila melanogaster; Glycogen; | 2013 |
VEGF-releasing biodegradable nanospheres administered by craniotomy: a novel therapeutic approach in the APP/Ps1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloidogenic Proteins; Animals; Behavior, Animal; Cell Survival; Cells, Cultured | 2013 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Evaluation of poly(lactic-co-glycolic acid) plate and screw system for bone fixation.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Plates; Bone Screws; Disease Models, Ani | 2013 |
3D CMR mapping of metabolism by hyperpolarized 13C-pyruvate in ischemia-reperfusion.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; Feasibility Studies; Image Inte | 2013 |
Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model.
Topics: Acidosis; Androgen Antagonists; Animals; Crystalloid Solutions; Cyclodextrins; Disease Models, Anima | 2013 |
The PLGA implant as an antimitotic delivery system after experimental trabeculectomy.
Topics: Animals; Antimitotic Agents; Coated Materials, Biocompatible; Conjunctiva; Disease Models, Animal; D | 2013 |
Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism.
Topics: Amine Oxidase (Copper-Containing); Animals; Biomarkers; Bone Marrow Transplantation; Cells, Cultured | 2013 |
Effect of Hypotensive Resuscitation with a Novel Combination of Fluids in a Rabbit Model of Uncontrolled Hemorrhagic Shock.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Fluid Therapy; Hemodynamics; Hy | 2013 |
Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.
Topics: Adenosine Triphosphate; Animals; Aorta, Abdominal; Arterial Pressure; Blood Glucose; Cardiomegaly; D | 2013 |
Evaluations of therapeutic efficacy of intravitreal injected polylactic-glycolic acid microspheres loaded with triamcinolone acetonide on a rabbit model of uveitis.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Carriers; Glyc | 2014 |
Subchronic perinatal asphyxia in rats: embryo-foetal assessment of a new model of oxidative stress during critical period of development.
Topics: Animals; Asphyxia Neonatorum; Disease Models, Animal; Female; Glucose; Lactic Acid; Oxidative Stress | 2013 |
Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model.
Topics: Administration, Oral; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning | 2014 |
Exercise training at MLSS decreases weight gain and increases aerobic capacity in obese Zucker rats.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Female; Lactic Acid; Male; Obesity; Oxygen Consum | 2014 |
Antisense reduction of tau in adult mice protects against seizures.
Topics: Age Factors; Animals; Anticonvulsants; Central Nervous System; Convulsants; Disease Models, Animal; | 2013 |
Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury.
Topics: Alginates; Animals; Disease Models, Animal; Female; Gait; Glial Cell Line-Derived Neurotrophic Facto | 2013 |
The angiogenic effect of ONO-1301, a novel long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA, in a murine sponge model.
Topics: Administration, Topical; Angiogenesis Inducing Agents; Animals; Chemistry, Pharmaceutical; Delayed-A | 2014 |
Comparison and characterization of multiple biomaterial conduits for peripheral nerve repair.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Electrophysiological Phenomena; Female; La | 2013 |
Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model.
Topics: Alginates; Animals; Apoptosis; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; G | 2013 |
Therapeutic potential of biodegradable microparticles containing Punica granatum L. (pomegranate) in murine model of asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, | 2013 |
Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids.
Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Depression; Disease Models, Animal; Dopamine; Gene E | 2014 |
α1-Syntrophin-deficient mice exhibit impaired muscle force recovery after osmotic shock.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; In Vitro Techniques; Lactic Acid; Membran | 2014 |
Pyruvate Ringer's solution corrects lactic acidosis and prolongs survival during hemorrhagic shock in rats.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Arterial Pressure; Carbon Dioxide; Disease Models, | 2013 |
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
Topics: Adult; Aged; Alanine; Animals; Breast Neoplasms; Cell Death; Cell Hypoxia; Cell Line, Tumor; Coumari | 2013 |
The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage.
Topics: Adipose Tissue; Aldehyde Dehydrogenase 1 Family; Animals; Cell Culture Techniques; Cell Proliferatio | 2013 |
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.
Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis | 2014 |
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model.
Topics: Aldehyde Reductase; Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; B | 2013 |
PD98059-impregnated functional PLGA scaffold for direct tissue engineering promotes chondrogenesis and prevents hypertrophy from mesenchymal stem cells.
Topics: Adult; Animals; Chondrogenesis; Collagen; Disease Models, Animal; Flavonoids; Humans; Hypertrophy; I | 2014 |
Combination of chondroitinase ABC, glial cell line-derived neurotrophic factor and Nogo A antibody delayed-release microspheres promotes the functional recovery of spinal cord injury.
Topics: Animals; Antibodies; Chondroitin ABC Lyase; Delayed-Action Preparations; Disease Models, Animal; Dru | 2013 |
[Pharmacological postconditioning with lactic acid and low dose edaravone could attenuate myocardial reperfusion injury through mitochondrial pathway].
Topics: Animals; Antipyrine; Apoptosis; Cytochromes c; Disease Models, Animal; Edaravone; Ischemic Postcondi | 2013 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Di | 2014 |
Surveillance of intra-abdominal pressure and intestinal barrier function in a rat model of acute necrotizing pancreatitis and its potential early therapeutic window.
Topics: Amine Oxidase (Copper-Containing); Amylases; Animals; Cholagogues and Choleretics; Disease Models, A | 2013 |
Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention.
Topics: Adaptation, Physiological; Aging; Alzheimer Disease; Animals; Astrocytes; Biological Transport, Acti | 2013 |
The effects of tranexamic acid and prothrombin complex concentrate on the coagulopathy of trauma: an in vitro analysis of the impact of severe acidosis.
Topics: Acidosis; Animals; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Factors; | 2013 |
Liver hydrolysate assists in the recovery from physical fatigue in a mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; En | 2013 |
Extended release local anesthetic agents in a postoperative arthritic pain model.
Topics: Anesthetics; Anesthetics, Local; Animals; Bupivacaine; Castor Oil; Chemistry, Pharmaceutical; Delaye | 2014 |
Low-molecular-weight heparin (LMWH)-loaded large porous PEG-PLGA particles for the treatment of asthma.
Topics: Administration, Inhalation; Airway Remodeling; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Age | 2014 |
Nanopatterned muscle cell patches for enhanced myogenesis and dystrophin expression in a mouse model of muscular dystrophy.
Topics: Animals; Disease Models, Animal; Dystrophin; Lactic Acid; Male; Mice; Microscopy, Atomic Force; Musc | 2014 |
The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria.
Topics: Animals; Bone and Bones; Bone Cements; Capsules; Disease Models, Animal; Emulsions; Lactic Acid; Mic | 2014 |
Early deficits in glycolysis are specific to striatal neurons from a rat model of huntington disease.
Topics: Animals; Cell Respiration; Corpus Striatum; Disease Models, Animal; Extracellular Space; Glucose; Gl | 2013 |
Effects of releasing recombinant human growth and differentiation factor-5 from poly(lactic-co-glycolic acid) microspheres for repair of the rat degenerated intervertebral disc.
Topics: Aggrecans; Animals; Biocompatible Materials; Collagen; Delayed-Action Preparations; Disease Models, | 2014 |
Altered gut microbiota and activity in a murine model of autism spectrum disorders.
Topics: Acetic Acid; Animals; Butyric Acid; Child Development Disorders, Pervasive; Disease Models, Animal; | 2014 |
Metastasis suppressor KISS1 seems to reverse the Warburg effect by enhancing mitochondrial biogenesis.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Extracellular Space; Female; Gene Expression; Glu | 2014 |
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di | 2014 |
A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells.
Topics: Adipose Tissue; Animals; Biocompatible Materials; Cell Differentiation; Disease Models, Animal; Grow | 2014 |
Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma.
Topics: Adjuvants, Immunologic; Animals; Arecaceae; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, | 2013 |
Hindbrain lactostasis regulates hypothalamic AMPK activity and metabolic neurotransmitter mRNA and protein responses to hypoglycemia.
Topics: Adrenergic Neurons; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Energy Metabolis | 2014 |
Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kit(w-Sh) murine model.
Topics: Animals; Biocompatible Materials; Cell Count; Disease Models, Animal; Fibrosis; Foreign Bodies; Fore | 2014 |
MARCOing monocytes for elimination.
Topics: Animals; Cell Death; Disease Models, Animal; Humans; Lactic Acid; Mice; Microspheres; Monocytes; Myo | 2014 |
PLGA-nanoparticle mediated delivery of anti-OX40 monoclonal antibody enhances anti-tumor cytotoxic T cell responses.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Proliferation; Cells, Cultured; Clinical T | 2014 |
In vivo investigation of calcium phosphate coatings on Ti6-Al-4V alloy substrates using lactic acid - sodium lactate buffered synthetic body fluid.
Topics: Alloys; Animals; Biocompatible Materials; Body Fluids; Bone Substitutes; Calcium Phosphates; Coated | 2013 |
Study on preparation of fibrinogen-loaded poly (L-lactic) acid nano-fabrics and its haemostatic performance in swine traumatic haemorrhage models.
Topics: Animals; Disease Models, Animal; Fibrinogen; Hemostatics; Humans; Lactic Acid; Microscopy, Electron, | 2014 |
Intraperitoneal metabolic consequences of supraceliac aortic balloon occlusion in an experimental animal study using microdialysis.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Follow-Up Studies; Glucose; Hemodynamics; Lacti | 2014 |
Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cattle; Cell Differentiation; Collagen; Di | 2014 |
Abdominal hypertension and decompression: the effect on peritoneal metabolism in an experimental porcine study.
Topics: Animals; Blood Pressure; Decompression, Surgical; Disease Models, Animal; Female; Glucose; Hemodynam | 2014 |
The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action.
Topics: Acetic Acid; Amine Oxidase (Copper-Containing); Animals; Astragalus propinquus; Colitis, Ulcerative; | 2014 |
Role of HGF-loaded nanoparticles in treating rat acute hepatic failure.
Topics: Animals; Biomarkers; Cells, Cultured; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparatio | 2013 |
Characterization of lactate utilization and its implication on the physiology of Haemophilus influenzae.
Topics: Animals; Blood Bactericidal Activity; Disease Models, Animal; Energy Metabolism; Gene Deletion; Gene | 2014 |
Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in mouse models of inflammatory bowel diseases.
Topics: Animals; Anti-Inflammatory Agents; Budesonide; Cytokines; Disease Models, Animal; Drug Carriers; Dru | 2014 |
Mesenteric lymph drainage alleviates acute kidney injury induced by hemorrhagic shock without resuscitation.
Topics: 2,3-Diphosphoglycerate; Acute Kidney Injury; Animals; Biomarkers; Disease Models, Animal; Drainage; | 2014 |
Intranasal delivery of nanoparticles encapsulating BPI3V proteins induces an early humoral immune response in mice.
Topics: Administration, Intranasal; Animals; Antibodies, Viral; Cattle; Cattle Diseases; Disease Models, Ani | 2014 |
Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel.
Topics: Animals; Bone Morphogenetic Proteins; Bone Regeneration; Bone Substitutes; Cells, Cultured; Delayed- | 2014 |
Cardioprotective activity of placental growth factor in a rat model of acute myocardial infarction: nanoparticle-based delivery versus direct myocardial injection.
Topics: Animals; Cardiotonic Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, | 2014 |
Development of a new nanofiber scaffold for use with stem cells in a third degree burn animal model.
Topics: Animals; Burns; Disease Models, Animal; Lactic Acid; Mesenchymal Stem Cells; Mice; Nanofibers; Polye | 2014 |
Improved antitumor activity and reduced cardiotoxicity of epirubicin using hepatocyte-targeted nanoparticles combined with tocotrienols against hepatocellular carcinoma in mice.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; C | 2014 |
Beyond Warburg effect--dual metabolic nature of cancer cells.
Topics: Acidosis, Lactic; Animals; Biological Transport; Cell Line, Tumor; Cell Proliferation; Disease Model | 2014 |
Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate.
Topics: Analysis of Variance; Animals; Bleomycin; Carbon Isotopes; Disease Models, Animal; Inflammation; Lac | 2014 |
Coating of electrospun poly(lactic-co-glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model.
Topics: Animals; Bone and Bones; Bone Regeneration; Ceramics; Disease Models, Animal; Lactic Acid; Nanofiber | 2014 |
Changes in intestinal microflora in rats with acute respiratory distress syndrome.
Topics: Acute Lung Injury; Amine Oxidase (Copper-Containing); Animals; Biodiversity; Disease Models, Animal; | 2014 |
Aerosolized montelukast polymeric particles-an alternative to oral montelukast-alleviate symptoms of asthma in a rodent model.
Topics: Acetates; Aerosols; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveola | 2014 |
Biphasic changes in fetal heart rate variability in preterm fetal sheep developing hypotension after acute on chronic lipopolysaccharide exposure.
Topics: Animals; Arterial Pressure; Biomarkers; Blood Gas Analysis; Blood Glucose; Bradycardia; Circadian Rh | 2014 |
Acceleration of aneurysm healing by P(DLLA-co-TMC)-coated coils enabling the controlled release of vascular endothelial growth factor.
Topics: Aneurysm; Animals; Carotid Artery, Common; Cell Proliferation; Coated Materials, Biocompatible; Dise | 2014 |
Development of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergy.
Topics: Adjuvants, Immunologic; Animals; Antigens, Dermatophagoides; Bronchial Hyperreactivity; Chemistry, P | 2014 |
pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Line; Colitis; Colon; Curcumin; Dextran Sulfat | 2014 |
[Effect of JTS caps. treating cerebral ischemia on metabolism and antioxidant system in cerebral ischemia rat].
Topics: Amino Acids; Animals; Antioxidants; Brain; Brain Ischemia; Catalase; Disease Models, Animal; Drugs, | 2014 |
[Effects of Shenqi preparation on anti-fatigue and anti-oxidant functions in mice].
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Disease Models, Animal; Drugs, Chinese Herbal; Fatigue; | 2014 |
Utilization of extracorporeal membrane oxygenation alleviates intestinal ischemia-reperfusion injury in prolonged hemorrhagic shock animal model.
Topics: Animals; Blood Pressure; Claudin-1; Disease Models, Animal; Extracorporeal Membrane Oxygenation; Int | 2014 |
Brain susceptibility weighted imaging signal changes in acute hemorrhagic anemia: an experimental study using a rabbit model.
Topics: Anemia; Animals; Bloodletting; Brain; Disease Models, Animal; Erythrocyte Count; Hematocrit; Hemoglo | 2014 |
Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma.
Topics: Animals; Burns; Disease Models, Animal; Ghrelin; Lactic Acid; Male; Muscle, Skeletal; Protein Serine | 2014 |
Detecting brain injury in neonatal hypoxic ischemic encephalopathy: closing the gap between experimental and clinical research.
Topics: Analysis of Variance; Animals; Animals, Newborn; Blood Pressure; Brain Injuries; Disease Models, Ani | 2014 |
Neuroprotective Effect of Transplanted Neural Precursors Embedded on PLA/CS Scaffold in an Animal Model of Multiple Sclerosis.
Topics: Animals; Axons; Cell Differentiation; Cell- and Tissue-Based Therapy; Disease Models, Animal; Lactic | 2015 |
17α-Ethynylestradiol-3-sulfate treatment of severe blood loss in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Et | 2015 |
Effects of pyruvate-enriched peritoneal dialysis solution on intestinal barrier in peritoneal resuscitation from hemorrhagic shock in rats.
Topics: Animals; Blood Pressure; Cell Adhesion Molecules; Dialysis Solutions; Disease Models, Animal; Intest | 2015 |
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury.
Topics: Analysis of Variance; Animals; Brain Concussion; Brain Edema; Disease Models, Animal; Lactic Acid; M | 2014 |
Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock.
Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Fluid Therapy; Hemodynamics; Hydrogen-Ion Co | 2014 |
Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction.
Topics: Alendronate; Angiogenesis Inducing Agents; Animals; Becaplermin; Biocompatible Materials; Bone and B | 2014 |
A novel design biodegradable stent for use in congenital heart disease: mid-term results in rabbit descending aorta.
Topics: Absorbable Implants; Animals; Aorta, Thoracic; Aortic Diseases; Aortography; Arterial Occlusive Dise | 2015 |
Dicer mediating the expression of miR-143 and miR-155 regulates hexokinase II associated cellular response to hypoxia.
Topics: Animals; Apoptosis; Biological Transport; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Gl | 2014 |
Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Cell Adhesion Molecules; Chemistry, Pharmaceutical; Chr | 2014 |
Effect of rhubarb pre-treatment on intestinal microcirculation in septic rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Dobutamine; Endothelial Cells; | 2014 |
Lactic acidosis treatment by nanomole level of spermidine in an animal model.
Topics: Acidosis, Lactic; Animals; Disease Models, Animal; Hydrogen-Ion Concentration; Lactic Acid; Male; Ra | 2014 |
Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Ischemia; Lactic Acid; Magnetic Fields; Magnetic | 2014 |
Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Disease Models, Animal; Forelimb; Ganglia, Spina | 2014 |
Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Brain Neoplasms; Disease Mo | 2014 |
Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood.
Topics: Animals; Bacteremia; Blood; Disease Models, Animal; Female; Fermentation; Gene Deletion; L-Lactate D | 2014 |
Dual-layer surface coating of PLGA-based nanoparticles provides slow-release drug delivery to achieve metronomic therapy in a paclitaxel-resistant murine ovarian cancer model.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Delayed-Ac | 2014 |
Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Delayed-Ac | 2014 |
A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume.
Topics: Animals; Biological Transport; Blood Pressure; Blood Substitutes; Blood Volume; Carbon Dioxide; Carb | 2015 |
The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse.
Topics: Animals; Brain Ischemia; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Gliosis; Hum | 2014 |
Effects of intraosseous erythropoietin during hemorrhagic shock in swine.
Topics: Animals; Cytokines; Disease Models, Animal; Erythropoietin; Heart; Hemodynamics; Infusions, Intraoss | 2014 |
Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity.
Topics: Animals; Antibiotics, Antineoplastic; Biodiversity; Diabetes Mellitus, Experimental; Diabetes Mellit | 2015 |
Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: in vitro intracellular activity and in vivo efficacy in a Guinea pig model of tuberculosis.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Drug Carriers; Female; Guinea Pigs; Humans; | 2014 |
The effects of D-allose on transient ischemic neuronal death and analysis of its mechanism.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Cerebral Cortex; Deoxyguanosine; Disease | 2014 |
Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.
Topics: Animals; Capillary Permeability; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; | 2015 |
Investigating sodium valproate as a treatment for McArdle disease in sheep.
Topics: Animals; Aspartate Aminotransferases; Calcium; Creatine Kinase; Disease Models, Animal; Drug Adminis | 2015 |
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cells, C | 2015 |
Sustained intravitreal delivery of connexin43 mimetic peptide by poly(D,L-lactide-co-glycolide) acid micro- and nanoparticles--Closing the gap in retinal ischaemia.
Topics: Animals; Connexin 43; Delayed-Action Preparations; Disease Models, Animal; Down-Regulation; Drug Car | 2015 |
Isoflavone and protein constituents of lactic acid-fermented soy milk combine to prevent dyslipidemia in rats fed a high cholesterol diet.
Topics: Animals; Biomarkers; Cholesterol, Dietary; Cultured Milk Products; Diet, High-Fat; Disease Models, A | 2014 |
Comparison of Noninvasive pH and Blood Lactate as Predictors of Mortality in a Swine Hemorrhagic Shock with Restricted Volume Resuscitation Model.
Topics: Animals; Area Under Curve; Disease Models, Animal; Hemorrhage; Hydrogen-Ion Concentration; Lactic Ac | 2015 |
Drug-loaded PLGA-mPEG microparticles as treatment for atopic dermatitis-like skin lesions in BALB/c mice model.
Topics: Administration, Topical; Animals; Benzimidazoles; Delayed-Action Preparations; Dermatitis, Atopic; D | 2015 |
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.
Topics: Animals; Antigens; CD4-Positive T-Lymphocytes; Disease Models, Animal; Encephalomyelitis, Autoimmune | 2015 |
Preparation and evaluation of a novel biodegradable long-acting intravitreal implant containing ligustrazine for the treatment of proliferative vitreoretinopathy.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Delayed-Action Preparations; Disease Models, | 2015 |
Neuroprotective activity of creatylglycine ethyl ester fumarate.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Behavior, Animal; Brain; Cell Survival; Creatine Kina | 2015 |
Development of porous PLGA/PEI1.8k biodegradable microspheres for the delivery of mesenchymal stem cells (MSCs).
Topics: Animals; Cell Adhesion; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Survival; Cells | 2015 |
Hemorrhagic hypotension-induced hypersensitivity of vagal pulmonary C-fibers to chemical stimulation and lung inflation in anesthetized rats.
Topics: Action Potentials; Animals; Arterial Pressure; Chemoreceptor Cells; Disease Models, Animal; Hemorrha | 2015 |
Preparation of an injectable depot system for long-term delivery of alendronate and evaluation of its anti-osteoporotic effect in an ovariectomized rat model.
Topics: Alendronate; Animals; Bone Density; Bone Density Conservation Agents; Chemistry, Pharmaceutical; Del | 2015 |
In a rat model of panic, corticotropin responses to dorsal periaqueductal gray stimulation depend on physical exertion.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; Disease Models, Animal; Elec | 2015 |
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; | 2015 |
Changes in lactate content and monocarboxylate transporter 2 expression in Aβ₂₅₋₃₅-treated rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition Disorders; Disease Mod | 2015 |
Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization.
Topics: Animals; beta Catenin; Cell Movement; Cell Proliferation; Cells, Cultured; Cornea; Corneal Neovascul | 2015 |
PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferati | 2015 |
Liver-targeted cyclosporine A-encapsulated poly (lactic-co-glycolic) acid nanoparticles inhibit hepatitis C virus replication.
Topics: Animals; Antiviral Agents; Cyclosporine; Disease Models, Animal; Hepacivirus; Hepatitis C; Lactic Ac | 2015 |
Epicardial delivery of VEGF and cardiac stem cells guided by 3-dimensional PLLA mat enhancing cardiac regeneration and angiogenesis in acute myocardial infarction.
Topics: Angiogenesis Inducing Agents; Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cell | 2015 |
Influence of bone marrow-derived mesenchymal stem cells pre-implantation differentiation approach on periodontal regeneration in vivo.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Caproates; Cell Culture Tech | 2015 |
Polymeric electrospun scaffolds: neuregulin encapsulation and biocompatibility studies in a model of myocardial ischemia.
Topics: Animals; Biocompatible Materials; Cell Polarity; Disease Models, Animal; Female; Lactic Acid; Macrop | 2015 |
Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Stem; Disease Models, Animal; Disease Progres | 2015 |
Enhanced engraftment and repairing ability of human adipose-derived stem cells, conveyed by pharmacologically active microcarriers continuously releasing HGF and IGF-1, in healing myocardial infarction in rats.
Topics: Adipose Tissue; Animals; Arrhythmias, Cardiac; Biomimetic Materials; Disease Models, Animal; Drug Ca | 2015 |
Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model.
Topics: Analysis of Variance; Animals; Biocompatible Materials; Brain Injuries; Caspase 3; Caspase 9; Curcum | 2015 |
Comparison of Shenfu Injection () and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest.
Topics: Animals; Cardiac Output; Cardiopulmonary Resuscitation; Catecholamines; Disease Models, Animal; Drug | 2016 |
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
Topics: Amides; Animals; Choroidal Neovascularization; Disease Models, Animal; Drug Carriers; Female; I-kapp | 2015 |
Brain glucose metabolism in an animal model of depression.
Topics: Administration, Oral; Animals; Brain; Depression; Disease Models, Animal; Female; Glucose; Glucoseph | 2015 |
Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Fibrosarcoma; Hypoxia; Lactic Acid; Magnetic Reson | 2015 |
Respiratory deficits in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Cell Count; Corpus Striatum; Disease Models, Animal; Hydrogen-Ion Concen | 2015 |
Glycolytic dependency of high-level nitric oxide resistance and virulence in Staphylococcus aureus.
Topics: Animals; Disease Models, Animal; Drug Tolerance; Female; Fermentation; Glycolysis; Lactic Acid; Mice | 2015 |
Is microdialysis useful for early detection of acute rejection after kidney transplantation?
Topics: Acute Disease; Animals; Biomarkers; Disease Models, Animal; Early Diagnosis; Glucose; Glycerol; Graf | 2015 |
Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.
Topics: Animals; Antigen Presentation; Breast Neoplasms; Cancer Vaccines; Cell Transformation, Neoplastic; D | 2015 |
The influence of extracorporeal membrane oxygenation therapy on intestinal mucosal barrier in a porcine model for post-traumatic acute respiratory distress syndrome.
Topics: Animals; Disease Models, Animal; Extracorporeal Membrane Oxygenation; Fatty Acid-Binding Proteins; F | 2015 |
Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Lactic Acid; Male; Physical Conditioning, A | 2015 |
Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats.
Topics: Animals; Apoptosis; Caspase 8; Disease Models, Animal; Female; Hydrogen; Ischemic Postconditioning; | 2015 |
Development of thalidomide-loaded biodegradable devices and evaluation of the effect on inhibition of inflammation and angiogenesis after subcutaneous application.
Topics: Acetylglucosaminidase; Animals; Biocompatible Materials; Calorimetry, Differential Scanning; Disease | 2015 |
Extensive regeneration of the stomach using bioabsorbable polymer sheets.
Topics: Absorbable Implants; Animals; Caproates; Disease Models, Animal; Female; Gastrectomy; Guided Tissue | 2015 |
5-HT1A receptors of the nucleus tractus solitarii facilitate sympathetic recovery following hypotensive hemorrhage in rats.
Topics: Animals; Baroreflex; Blood Pressure; Blood Volume; Disease Models, Animal; Hemorrhage; Hypotension; | 2015 |
Age-dependent neuromuscular impairment in prion protein knockout mice.
Topics: Action Potentials; Adenosine Triphosphatases; Aging; Animals; Citrate (si)-Synthase; Disease Models, | 2016 |
Experimental evidence that bioenergetics disruption is not mainly involved in the brain injury of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases; Brain Diseases, Metabolic; Cerebral C | 2015 |
Hextend-perfluorocarbon cocktail inhibits mean arterial pressure response in a rabbit shock model.
Topics: Acidosis, Lactic; Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Drug Evaluatio | 2015 |
3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury.
Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Line; Disease Models, Animal; Electron Transport Comple | 2015 |
The effect of AZD2171- or sTRAIL/Apo2L-loaded polylactic-co-glycolic acid microspheres on a subcutaneous glioblastoma model.
Topics: Animals; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, Animal; Glioblastoma; Glycol | 2015 |
Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
Topics: Animals; Biomarkers; Disease Models, Animal; Fluid Therapy; Hemodynamics; Inflammation Mediators; In | 2015 |
Histologic and Histometric Analysis of Bone Repair at the Site of Mandibular Body Osteotomy and at the Bone-Screw Interface After Using a Biodegradable 2.0-mm Internal Fixation System.
Topics: Absorbable Implants; Animals; Bone Plates; Bone Screws; Disease Models, Animal; Dogs; Fracture Fixat | 2015 |
Drag-reducing polymers increase exercise tolerance in an ischemic hind-limb rat model.
Topics: Animals; Biomarkers; Cardiovascular Agents; Creatine Kinase; Disease Models, Animal; Exercise Tolera | 2016 |
Comparison of Malated Ringer's with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats.
Topics: Acidosis; Animals; Crystalloid Solutions; Disease Models, Animal; Humans; Isotonic Solutions; Lactic | 2015 |
Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation.
Topics: Animals; Anti-Bacterial Agents; Cytokines; Disease Models, Animal; Female; Humans; Hypersensitivity; | 2015 |
TNFR1 Regulates Ovarian Cancer Cell Tumorigenicity Through PIK3CB-p110Beta.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Class I Phosphatidylinositol 3-Kinases; | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec | 2015 |
Injectable PLGA microspheres encapsulating WKYMVM peptide for neovascularization.
Topics: Animals; Aorta; Cell Movement; Cell Proliferation; Disease Models, Animal; Emulsions; Gene Expressio | 2015 |
Vaccine potential of plasma bead-based dual antigen delivery system against experimental murine candidiasis.
Topics: Animals; Antigen-Presenting Cells; Antigens, Fungal; Biocompatible Materials; Biopolymers; Candida; | 2015 |
Metformin suppresses intrahepatic coagulation activation in mice with lipopolysaccharide/D‑galactosamine‑induced fulminant hepatitis.
Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Disease Models, Animal; Erythropoietin; Galact | 2015 |
Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats.
Topics: Administration, Cutaneous; Alginates; Animals; Bandages; Burns; Chemistry, Pharmaceutical; Cicatrix; | 2015 |
Reconstruction of Segmental Stability of Goat Cervical Spine with Poly (D, L-lactic acid) Cage.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Biomechanical Phenomena; Bone Transplantation | 2015 |
Shenfu injection alleviates intestine epithelial damage in septic rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Disease Models, Animal; Dose-Response Relationship, Drug | 2015 |
Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain.
Topics: Animals; Brain; Choline; Convulsants; Disease Models, Animal; Electrochemistry; Electron Transport C | 2015 |
Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals.
Topics: Animals; Blood Vessels; Cell Differentiation; Cell Proliferation; Coculture Techniques; Disease Mode | 2016 |
Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.
Topics: Animals; Apoptosis; Area Under Curve; Biotransformation; Blood-Brain Barrier; Brain; Brain Injuries; | 2015 |
Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma.
Topics: Aconitine; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Dichloroaceti | 2015 |
Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Bone Neoplasms; Caspase 3; Cell Line, Tumor; | 2015 |
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Edema; Gene Expression Regulation; Hyperalgesia; I | 2015 |
Enhanced Hippocampal Neurogenesis in APP/Ps1 Mouse Model of Alzheimer's Disease After Implantation of VEGF-loaded PLGA Nanospheres.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biodegradable Plastics; Cell Proliferati | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Tracking the in vivo release of bioactive NRG from PLGA and PEG-PLGA microparticles in infarcted hearts.
Topics: Animals; Biological Availability; Biotinylation; Cardiovascular Agents; Delayed-Action Preparations; | 2015 |
Two highly adhesive lactic acid bacteria strains are protective in zebrafish infected with Aeromonas hydrophila by evocation of gut mucosal immunity.
Topics: Aeromonas hydrophila; Animals; Bacterial Adhesion; Disease Models, Animal; Gram-Negative Bacterial I | 2016 |
Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish.
Topics: Animals; Antitubercular Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Therapy | 2016 |
Glucose Oxidation Is Critical for CD4+ T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cells, Cultured; Deoxyglucose; Dichloroacetic Aci | 2016 |
Activation of α2 adrenoceptor attenuates lipopolysaccharide-induced hepatic injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Alanine Transaminase; | 2015 |
Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix.
Topics: Animals; Aortic Aneurysm, Abdominal; Delayed-Action Preparations; Disease Models, Animal; Elasticity | 2016 |
Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Aspartic Acid; Biomarkers; Brain Mapping; Disease | 2016 |
Biliary tract external drainage protects against intestinal barrier injury in hemorrhagic shock rats.
Topics: Animals; Biliary Tract Surgical Procedures; Biomarkers; Blotting, Western; Claudin-1; Disease Models | 2015 |
Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Argon; Aspartic Acid; Asphyxia Neonatorum; Blood Chemical Analysis; Blood | 2016 |
Development of zolmitriptan loaded PLGA/poloxamer nanoparticles for migraine using quality by design approach.
Topics: Animals; Brain; Calorimetry, Differential Scanning; Disease Models, Animal; Drug Carriers; Drug Deli | 2016 |
Time- and dose-dependent severity of lung injury in a rat model of sepsis.
Topics: Alanine Transaminase; Animals; Arteries; Aspartate Aminotransferases; Blood Gas Analysis; Blood Urea | 2015 |
Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections.
Topics: Animals; Anti-Bacterial Agents; Antirheumatic Agents; Auranofin; Biofilms; Disease Models, Animal; D | 2016 |
[Efficacy and mechanism of local delivery of rapamycin and rapamycin-loaded poly(lactic-co-glycolic) acid nanoparticles on coronary restenosis of injury-stenosis model of minipigs].
Topics: Animals; Constriction, Pathologic; Disease Models, Animal; Lactic Acid; Nanoparticles; Polyglycolic | 2016 |
Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo A Biomarker for LDH Activity.
Topics: Adult; Animals; Biomarkers; Disease Models, Animal; Humans; L-Lactate Dehydrogenase; Lactic Acid; Ly | 2016 |
Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth.
Topics: Animals; Diet; Dietary Sucrose; Disease Models, Animal; Drosophila; Female; Lactic Acid; Male; Mitoc | 2016 |
Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice.
Topics: Administration, Intravenous; Angiotensin II; Animals; Apolipoproteins E; Atherosclerosis; Brachiocep | 2016 |
Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening.
Topics: Animals; bcl-2-Associated X Protein; Cardiotonic Agents; Cells, Cultured; Cyclosporine; Cytochromes | 2016 |
Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model.
Topics: Aggrecans; Animals; Biocompatible Materials; Collagen Type I; Collagen Type II; Disease Models, Anim | 2016 |
A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein.
Topics: Animals; Bacteria; Biofilms; Dental Implants; Disease Models, Animal; DNA-Binding Proteins; Escheric | 2017 |
Gelatin-poly(lactic-co-glycolic acid) scaffolds with oriented pore channel architecture - From in vitro to in vivo testing.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Collagen Type II; Disease Models, Anim | 2016 |
Determination of anti-tuberculosis drug concentration and distribution from sustained release microspheres in the vertebrae of a spinal tuberculosis rabbit model.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Drug Delivery Systems; Durapatite; Female; I | 2017 |
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injury.
Topics: Angioplasty, Balloon; Animals; Aorta; Cardiovascular Agents; Carotid Artery Diseases; Cell Movement; | 2017 |
Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model.
Topics: Administration, Intravaginal; Animals; Anti-HIV Agents; Disease Models, Animal; Emulsifying Agents; | 2016 |
Transplantation of bone marrow-derived mesenchymal stem cells expressing elastin alleviates pelvic floor dysfunction.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Collagen; Disease Models, Animal; Drug Compounding | 2016 |
Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antibody Formation; CD4-Positive T-Lymphocyt | 2016 |
Intestinal Conditioning After Cardiac Arrest: The Use of Normothermic Extracorporeal Membrane Oxygenation in the Non-Heart-Beating Animal Model.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Body Temperature; Disease Models, Animal; Energy Metabol | 2016 |
Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs.
Topics: Animals; Bicarbonates; Burns; Capillary Permeability; Disease Models, Animal; Dogs; Fluid Therapy; F | 2016 |
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy.
Topics: Allergens; Animals; Arachis; Cytokines; Desensitization, Immunologic; Disease Models, Animal; Female | 2016 |
Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure.
Topics: Animals; Brain; Deoxyglucose; Disease Models, Animal; Electroencephalography; Energy Metabolism; Exp | 2016 |
Hepatic glycogen can regulate hypoglycemic counterregulation via a liver-brain axis.
Topics: Animals; Blood Glucose; Brain; Diabetes Mellitus, Type 1; Disease Models, Animal; Dogs; Female; Fruc | 2016 |
Isolation of lactic acid bacteria from swine milk and characterization of potential probiotic strains with antagonistic effects against swine-associated gastrointestinal pathogens.
Topics: Animals; Disease Models, Animal; Drug Resistance, Bacterial; Gastrointestinal Tract; Hemolysin Prote | 2016 |
Characterization of a Mouse Model of Oral Potassium Cyanide Intoxication.
Topics: Animals; Biomarkers; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acid-B | 2016 |
Low-flow lower body perfusion for spinal protection in a frozen elephant trunk simulation model.
Topics: Animals; Aorta, Thoracic; Blood Vessel Prosthesis Implantation; Cardiopulmonary Bypass; Cerebrospina | 2016 |
Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats - A Pilot Trial.
Topics: Animals; Biomarkers; Blood Pressure; CA1 Region, Hippocampal; Cardiopulmonary Resuscitation; Cerebra | 2016 |
Catheter-based Intramyocardial Injection of FGF1 or NRG1-loaded MPs Improves Cardiac Function in a Preclinical Model of Ischemia-Reperfusion.
Topics: Administration, Cutaneous; Animals; Cell Line; Disease Models, Animal; Female; Fibroblast Growth Fac | 2016 |
Vascular smooth muscle desensitization in rabbit epigastric and mesenteric arteries during hemorrhagic shock.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Disease Models, | 2016 |
Targeted Polymeric Nanoparticles for Brain Delivery of High Molecular Weight Molecules in Lysosomal Storage Disorders.
Topics: Albumins; Animals; Blood-Brain Barrier; Disease Models, Animal; Drug Carriers; Enzyme Replacement Th | 2016 |
Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI.
Topics: Algorithms; Animals; Carbon Isotopes; Computer Simulation; Disease Models, Animal; Image Processing, | 2016 |
Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect.
Topics: Animals; Biocompatible Materials; Bone Regeneration; Cell Movement; Disease Models, Animal; Durapati | 2016 |
Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model.
Topics: Adenosine Triphosphate; Animals; Atorvastatin; Creatine Kinase; Disease Models, Animal; Hydroxymethy | 2016 |
Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner.
Topics: Animals; Antioxidants; Dinoprost; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty A | 2016 |
Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.
Topics: Administration, Intravenous; Animals; Biphenyl Compounds; Cardiotonic Agents; Disease Models, Animal | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptoth | 2016 |
Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; An | 2016 |
A Translational Study of a New Therapeutic Approach for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduces Ischemia-Reperfusion Injury in a Preclinical Porcine Model.
Topics: Anesthesia; Animals; Blood Pressure; Cardiotonic Agents; Cell Death; Cells, Cultured; Consciousness; | 2016 |
In situ lactate dehydrogenase activity: a novel renal cortical imaging biomarker of tubular injury?
Topics: Acute Kidney Injury; Alanine; Animals; Bicarbonates; Biomarkers; Carbon Isotopes; Disease Models, An | 2017 |
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Biomarkers; C9orf72 Protein; Cell Communication; | 2016 |
Addition of Sodium Pyruvate to Stored Red Blood Cells Attenuates Liver Injury in a Murine Transfusion Model.
Topics: Animals; Blood Preservation; Blood Transfusion; Disease Models, Animal; Erythrocytes; Hemoglobins; H | 2016 |
Peripheral administration of lactate produces antidepressant-like effects.
Topics: Animals; Antidepressive Agents; Astrocytes; Depression; Depressive Disorder, Major; Disease Models, | 2018 |
Immunomodulatory Effects of Different Lactic Acid Bacteria on Allergic Response and Its Relationship with In Vitro Properties.
Topics: Allergens; Animals; Disease Models, Animal; Food Microbiology; Hypersensitivity; In Vitro Techniques | 2016 |
Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study.
Topics: Animals; Brain; Disease Models, Animal; Glucose; Head Injuries, Penetrating; Hypoxia; Lactic Acid; M | 2016 |
Multifunctional SPIO/DOX-loaded A54 Homing Peptide Functionalized Dextran-g-PLGA Micelles for Tumor Therapy and MR Imaging.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Contrast Media; Disease | 2016 |
Development of near zero-order release PLGA-based microspheres of a novel antipsychotic.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Chemistry, Pharmaceutical; Delayed-Action Prepa | 2017 |
MicroRNA-29 facilitates transplantation of bone marrow-derived mesenchymal stem cells to alleviate pelvic floor dysfunction by repressing elastin.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Disease Models, Animal; Elastin; Fibroblas | 2016 |
Attenuation of experimental autoimmune neuritis with locally administered lovastatin-encapsulating poly(lactic-co-glycolic) acid nanoparticles.
Topics: Animals; Capsules; Disease Models, Animal; Glycols; Guillain-Barre Syndrome; Lactic Acid; Lovastatin | 2017 |
Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma.
Topics: Acrylates; Animals; Caffeic Acids; Cell Line, Tumor; Coumaric Acids; Disease Models, Animal; Emboliz | 2017 |
Methylprednisolone improves lactate metabolism through reduction of elevated serum lactate in rat model of multiple sclerosis.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experiment | 2016 |
Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Colorectal Neoplasms; Disease Models, Animal | 2017 |
Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model.
Topics: Animals; Biomechanical Phenomena; Cartilage, Articular; Disease Models, Animal; Extracellular Matrix | 2017 |
Effect of an MG132-Sustained Drug Delivery Capsular Ring on the Inhibition of Posterior Capsule Opacification in a Rabbit Model.
Topics: Animals; Capsule Opacification; Disease Models, Animal; Drug Delivery Systems; Lactic Acid; Leupepti | 2017 |
Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy.
Topics: Animals; Biocompatible Materials; Cornea; Disease Models, Animal; Eye Infections, Viral; Flow Cytome | 2017 |
Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy.
Topics: Animals; Cholesterol; Coculture Techniques; Disease Models, Animal; Drug Delivery Systems; Drug Libe | 2017 |
Nanotechnology-Based Cancer Vaccine.
Topics: Animals; Cancer Vaccines; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy; Lactic Aci | 2017 |
Development of a single-dose recombinant CAMP factor entrapping poly(lactide-co-glycolide) microspheres-based vaccine against Streptococcus agalactiae.
Topics: Animals; Bacterial Load; Bacterial Proteins; Cattle; Cattle Diseases; China; Disease Models, Animal; | 2017 |
Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Disease Models, A | 2017 |
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study.
Topics: Animals; Brain; Disease Models, Animal; Female; Gene Expression; Glucose; Glycerol; Immunohistochemi | 2017 |
Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing.
Topics: Animals; Antibodies, Blocking; Biocompatible Materials; Chemokine CCL2; Disease Models, Animal; Embo | 2017 |
Lactate profiles as a resuscitation assessment tool in a rat model of battlefield hemorrhage resuscitation.
Topics: Animals; Disease Models, Animal; Hemoglobins; Hydroxyethyl Starch Derivatives; Lactic Acid; Male; Ra | 2008 |
Hypothermia reduces cytotoxic edema and metabolic alterations during the acute phase of massive SAH: a diffusion-weighted imaging and spectroscopy study in rats.
Topics: Acute Disease; Animals; Aspartic Acid; Body Temperature; Brain; Brain Edema; Cerebral Cortex; Creati | 2008 |
Evaluation of diaphragmatic hernia repair using PLGA mesh-collagen sponge hybrid scaffold: an experimental study in a rat model.
Topics: Animals; Collagen; Disease Models, Animal; Female; Hernia, Diaphragmatic; Lactic Acid; Polyglycolic | 2008 |
Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia.
Topics: Animals; Arachidonic Acids; Biopterins; Disease Models, Animal; Endocannabinoids; Endotoxemia; Hemod | 2008 |
Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction.
Topics: Acidosis; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Disease Models, Animal; Down-Regulati | 2009 |
A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Brain; Brain Chemistry; Choline; Creatine; | 2008 |
Bone regeneration of critical calvarial defect in goat model by PLGA/TCP/rhBMP-2 scaffolds prepared by low-temperature rapid-prototyping technology.
Topics: Animals; Biocompatible Materials; Biomedical Engineering; Bone Diseases; Bone Morphogenetic Protein | 2008 |
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Evoked Potentials, Somatosensor | 2008 |
Comparison of active and passive coronary perfusion in off-pump coronary artery bypass grafting.
Topics: Animals; Coronary Artery Bypass, Off-Pump; Coronary Circulation; Coronary Stenosis; Disease Models, | 2008 |
Matrix-guided cartilage regeneration in chondral defects.
Topics: Absorbable Implants; Animals; Arthroplasty, Subchondral; Cartilage, Articular; Chondrocytes; Collage | 2009 |
Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.
Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Energy Metabolism; Erythropoietin; G | 2008 |
Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study.
Topics: Animals; Animals, Newborn; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Disease Models, | 2009 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding.
Topics: Animals; Bioprosthesis; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Carotid Arter | 2008 |
Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Delivery Systems; Endoscopy; Female; Fluorescence | 2009 |
Rigid fixation of the spinal column improves scaffold alignment and prevents scoliosis in the transected rat spinal cord.
Topics: Animals; Barium Sulfate; Contrast Media; Disease Models, Animal; Female; Glycolates; Imaging, Three- | 2008 |
Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy.
Topics: Acyl-CoA Dehydrogenase; Animals; CD36 Antigens; Diabetes Mellitus, Type 2; Dietary Fats; Disease Mod | 2009 |
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.
Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Dise | 2008 |
Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model.
Topics: Angiogenesis Inhibitors; Animals; Delayed-Action Preparations; Disease Models, Animal; Endostatins; | 2009 |
The neointimal response to stents eluting tacrolimus from a degradable coating depends on the balance between polymer degradation and drug release.
Topics: Angioplasty, Balloon, Coronary; Animals; Coated Materials, Biocompatible; Coronary Vessels; Disease | 2008 |
Engineering angiogenesis following spinal cord injury: a coculture of neural progenitor and endothelial cells in a degradable polymer implant leads to an increase in vessel density and formation of the blood-spinal cord barrier.
Topics: Absorbable Implants; Animals; Blood Vessels; Blood-Brain Barrier; Cells, Cultured; Coculture Techniq | 2009 |
[The role of hypoxic syndrome in pathogenesis of experimental stress-lesions].
Topics: Animals; Biomarkers; Disease Models, Animal; Hypoxia; Lactic Acid; Male; Oxygen; Pain; Pain Manageme | 2008 |
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Topics: Animals; Behavior, Animal; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Choline; Corpus Striatum; | 2009 |
Effective GDNF brain delivery using microspheres--a promising strategy for Parkinson's disease.
Topics: Animals; Brain; Cell Differentiation; Corpus Striatum; Disease Models, Animal; Drug Carriers; Drug D | 2009 |
Gray matter metabolism in acute and chronic hydrocephalus.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Brain Mapping; Creatine; Disea | 2009 |
FK506 induces changes in muscle properties and promotes metabosensitive nerve fiber regeneration.
Topics: Animals; Disease Models, Animal; Growth Cones; Immunosuppressive Agents; Lactic Acid; Male; Muscle F | 2009 |
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Topics: ADAM Proteins; Animals; Carpus, Animal; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; | 2009 |
[The role of alimentary magnesium deficiency in development of nephrolithiasis and its correction with magnesium salts in rats].
Topics: Animals; Aspartic Acid; Disease Models, Animal; Lactic Acid; Magnesium Compounds; Magnesium Deficien | 2008 |
Assessment of a new experimental model of isolated right ventricular failure.
Topics: Animals; Disease Models, Animal; Dogs; Echocardiography; Ethanol; Heart; Heart Failure; Hemodynamics | 2009 |
MPTP intoxication in mice: a useful model of Leigh syndrome to study mitochondrial diseases in childhood.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Basal Ganglia; Basal Ganglia Diseases; Diseas | 2009 |
Therapeutic neovascularization by nanotechnology-mediated cell-selective delivery of pitavastatin into the vascular endothelium.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Animals; Cells, Cultured; Disease Models, Animal; | 2009 |
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase.
Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease | 2009 |
Designing a three-dimensional expanded polytetrafluoroethylene-poly(lactic-co-glycolic acid) scaffold for tissue engineering.
Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cell Adhesion; Cell Moveme | 2009 |
Development of animal model for calcified chronic total occlusion.
Topics: Animals; Apatites; Arterial Occlusive Diseases; Calcinosis; Chronic Disease; Coated Materials, Bioco | 2009 |
Protective effect of remote ischemic preconditioning in renal ischemia/reperfusion injury, in a model of thoracoabdominal aorta approach.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Disease Models, An | 2009 |
Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia.
Topics: Animals; Constriction; Disease Models, Animal; Female; Intestine, Small; Ischemia; Lactic Acid; Malo | 2009 |
Evaluation of a novel slow-release paclitaxel-eluting stent with a bioabsorbable polymeric surface coating.
Topics: Animals; Antineoplastic Agents, Phytogenic; Coated Materials, Biocompatible; Coronary Disease; Coron | 2008 |
Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord.
Topics: Animals; Asphyxia; Biomarkers; Blood Flow Velocity; Blood Pressure; Brain; Carbon Dioxide; Cerebrova | 2009 |
Hematological responses of the grey carpet shark (Chiloscyllium punctatum) and the epaulette shark (Hemiscyllium ocellatum) to anoxia and re-oxygenation.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Disease Models, Animal; Erythrocyte Count; Hemato | 2009 |
Oligonucleotide decoy to NF-kappaB slowly released from PLGA microspheres reduces chronic inflammation in rat.
Topics: Animals; Blotting, Western; Chronic Disease; Disease Models, Animal; Drug Carriers; Electrophoretic | 2009 |
Treatment outcomes of ligature-induced recession in the dog model using guided tissue regeneration or coronally positioned flap procedures.
Topics: Absorbable Implants; Alveolar Bone Loss; Alveolar Process; Animals; Bicuspid; Biopsy; Bone Regenerat | 2009 |
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects.
Topics: Animals; Bone Regeneration; Bone Substitutes; Cartilage, Articular; Disease Models, Animal; Fracture | 2010 |
Biodegradable microspherical implants containing teicoplanin for the treatment of methicillin-resistant Staphylococcus aureus osteomyelitis.
Topics: Absorbable Implants; Analysis of Variance; Animals; Anti-Bacterial Agents; Disease Models, Animal; D | 2010 |
Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Biophysics; Conditioning, Opera | 2009 |
Local sustained release of prostaglandin E1 induces neovascularization in murine hindlimb ischemia.
Topics: Alprostadil; Animals; Blood Vessels; Delayed-Action Preparations; Disease Models, Animal; Dose-Respo | 2009 |
Degradable PLGA scaffolds with basic fibroblast growth factor: experimental studies in myocardial revascularization.
Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Coronary Circulation; Coronary Stenosis; | 2009 |
Neuromuscular recovery pattern after medial collateral ligament disruption in rats.
Topics: Animals; Disease Models, Animal; Female; Femoral Nerve; Hindlimb; Knee Injuries; Knee Joint; Lactic | 2009 |
Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cell Adhesion Molecules, Neuronal; Child; Child | 2010 |
Initiation time of post-ischemic hypothermia on the therapeutic effect in cerebral ischemic injury.
Topics: Animals; Brain; Brain Ischemia; Chi-Square Distribution; Disease Models, Animal; Electrolytes; Hypot | 2009 |
Generation of mice with a conditional allele for G6pc.
Topics: Alleles; Animals; Blood Glucose; Cholesterol; Disease Models, Animal; DNA Primers; Gene Components; | 2009 |
How do poly lactide-co-glycolide microspheres for prostaglandin E1 operate in ischemic tissue? Local sustained release of prostaglandin E1 induces neovascularization in murine hindlimb ischemia.
Topics: Alprostadil; Animals; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Relationshi | 2009 |
Selective cerebral perfusion: real-time evidence of brain oxygen and energy metabolism preservation.
Topics: Animals; Animals, Newborn; Cardiopulmonary Bypass; Cerebrovascular Circulation; Circulatory Arrest, | 2009 |
Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.
Topics: Animals; Cell Line; Disease Models, Animal; Humans; I-kappa B Proteins; Indomethacin; Intestinal Dis | 2009 |
Effect of oxygen affinity on systemic perfusion and brain tissue oxygen tension after extreme hemodilution with hemoglobin-starch conjugates in rats.
Topics: Analysis of Variance; Anemia; Animals; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, | 2009 |
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
Topics: Animals; Body Weight; Cell Count; Disease Models, Animal; Ectodysplasins; Encephalitis; Infarction, | 2009 |
Effect of vagus nerve stimulation on thermal injury in rats.
Topics: Animals; Blood Pressure; Burns; Carbon Dioxide; Disease Models, Animal; Heart Rate; Interleukin-6; L | 2010 |
A dual-emissive-materials design concept enables tumour hypoxia imaging.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neopla | 2009 |
Neuroprotective role of lactate after cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Hippo | 2009 |
Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus.
Topics: Animals; Cell Line; Cervix Uteri; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Hyd | 2009 |
[Effects of ethyl pyruvate on injuries of sepsis in mice].
Topics: Alkaline Phosphatase; Animals; Disease Models, Animal; Intestines; Lactic Acid; Lung; Male; Mice; Py | 2009 |
Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer.
Topics: Animals; Biomarkers, Tumor; Carbon Isotopes; Diagnosis, Computer-Assisted; Disease Models, Animal; H | 2010 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; | 2010 |
1H-nuclear magnetic resonance spectroscopy-based metabolic assessment in a rat model of obesity induced by a high-fat diet.
Topics: Acetoacetates; Acetone; Animals; Betaine; Citric Acid; Dietary Fats; Disease Models, Animal; Glycine | 2009 |
Inotropic support during experimental endotoxemic shock: part I. The effects of levosimendan on splanchnic perfusion.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy | 2009 |
Inotropic support during experimental endotoxemic shock: part II. A comparison of levosimendan with dobutamine.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy | 2009 |
The protective effect of oxygenated perfluorocarbons (PFCs) on intestinal ischemia reperfusion injury (I/R) in rabbits.
Topics: Animals; Cell Survival; Cytoprotection; Disease Models, Animal; Fluorocarbons; Infusions, Parenteral | 2010 |
Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model.
Topics: Animals; Asthma; Betamethasone; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Delivery | 2009 |
Combination pharmacotherapy in the treatment of experimental cardiac arrest.
Topics: Adrenergic beta-Agonists; Animals; Atenolol; Cardiotonic Agents; Disease Models, Animal; Drug Therap | 2009 |
Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model.
Topics: Animals; Brachytherapy; Disease Models, Animal; Drug Carriers; Holmium; Humans; Lactic Acid; Liver; | 2010 |
Thioredoxin binding protein-2 inhibits excessive fetal hypoglycemia during maternal starvation by suppressing insulin secretion in mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Carrier Proteins; Disease Models | 2010 |
Asymmetric IgG antibodies induced by different immunotherapies in a murine model of allergy.
Topics: Animals; Cells, Cultured; Chromatography, Affinity; Desensitization, Immunologic; Disease Models, An | 2009 |
Relationship between fluorescence loss of QLF and depth of demineralization in an enamel erosion model.
Topics: Analysis of Variance; Animals; Cattle; Dental Caries; Dental Caries Activity Tests; Dental Enamel; D | 2009 |
Temporal and spatial CGRP innervation in recombinant human bone morphogenetic protein induced spinal fusion in rabbits.
Topics: Animals; Bone Morphogenetic Protein 1; Bone Regeneration; Calcitonin Gene-Related Peptide; Cartilage | 2009 |
A biodegradable scaffold for the treatment of a diaphyseal bone defect of the tibia.
Topics: Absorbable Implants; Animals; Bone Substitutes; Bone Transplantation; Calcium Phosphates; Disease Mo | 2010 |
Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.
Topics: Animals; Cardiomyopathy, Dilated; Cricetinae; Delayed-Action Preparations; Disease Models, Animal; D | 2009 |
Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia.
Topics: Analysis of Variance; Animals; Bone Marrow Cells; Brain Ischemia; Brain-Derived Neurotrophic Factor; | 2010 |
Rabbit retinal neovascularization induced by latex angiogenic-derived fraction: an experimental model.
Topics: Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Drug Carriers; Female; Fluorescein An | 2010 |
Multiple therapeutic effects of adjunctive baicalin therapy in experimental bacterial meningitis.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Blood Pressure; Brain Edema; Cere | 2010 |
Pharmacokinetics analysis of sustained release hGH biodegradable implantable tablets using a mouse model of human ovarian cancer.
Topics: Animals; Cell Proliferation; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Dru | 2010 |
Fetal cerebral energy metabolism and electrocardiogram during experimental umbilical cord occlusion and resuscitation.
Topics: Animals; Brain; Brain Chemistry; Cardiopulmonary Resuscitation; Disease Models, Animal; Electrocardi | 2010 |
A rabbit model for efficacy evaluation of endovascular coil materials.
Topics: Angiography, Digital Subtraction; Animals; Carotid Artery Diseases; Carotid Artery, Common; Cerebral | 2009 |
Protective effect of glutamine-enriched early enteral nutrition on intestinal mucosal barrier injury after liver transplantation in rats.
Topics: Animals; Bacterial Translocation; Biomarkers; Biopsy, Needle; Blotting, Western; Disease Models, Ani | 2010 |
(-)-Hinokinin-loaded poly(D,-lactide-co-glycolide) microparticles for Chagas disease.
Topics: 4-Butyrolactone; Animals; Antiprotozoal Agents; Benzodioxoles; Chagas Disease; Delayed-Action Prepar | 2010 |
Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis.
Topics: Animals; Anti-Infective Agents; Delayed-Action Preparations; Disease Models, Animal; Dose-Response R | 2010 |
Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study.
Topics: Analysis of Variance; Animals; Apoptosis; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Creatini | 2010 |
Reduced caloric intake during endotoxemia reduces arginine availability and metabolism.
Topics: Animals; Arginine; Disease Models, Animal; Endotoxemia; Endotoxins; Energy Intake; Escherichia coli; | 2010 |
[Reconstruction of osteochondral defects with a stem cell-based cartilage-polymer construct in a small animal model].
Topics: Animals; Bone and Bones; Bone Regeneration; Cell Differentiation; Chondrocytes; Chondrogenesis; Dise | 2010 |
In vivo cyclic loading as a potent stimulatory signal for bone formation inside tissue engineering scaffold.
Topics: Animals; Biomechanical Phenomena; Bone Diseases; Bone Regeneration; Bone Substitutes; Calcium Phosph | 2010 |
Metabolic markers obtained by microdialysis can detect secondary intestinal ischemia: an experimental study of ischemia in porcine intestinal segments.
Topics: Animals; Biomarkers; Disease Models, Animal; Glucose; Intestine, Small; Ischemia; Lactic Acid; Mesen | 2010 |
Electrospun synthetic polymer scaffold for cartilage repair without cultured cells in an animal model.
Topics: Absorbable Implants; Animals; Cartilage, Articular; Disease Models, Animal; Electrochemistry; Femur; | 2010 |
Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2010 |
Hypothermic protection in an acute hypoxia model in rats: Acid-base and oxidant/antioxidant profiles.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Antioxidants; Arteries; Disease Models, Animal; Glutathion | 2010 |
Bone repair by cell-seeded 3D-bioplotted composite scaffolds made of collagen treated tricalciumphosphate or tricalciumphosphate-chitosan-collagen hydrogel or PLGA in ovine critical-sized calvarial defects.
Topics: Absorbable Implants; Animals; Bone Regeneration; Calcium Phosphates; Chitosan; Collagen; Disease Mod | 2010 |
Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth.
Topics: Animals; Aorta; Biocompatible Materials; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2010 |
Exogenous modulation of intrinsic optic nerve neuroprotective activity.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Ciliary Neurotrophic Factor; Disease Mode | 2010 |
Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adjuvants, Immunologic; Administration, Intravesical; Aminoquinol | 2010 |
Hypoxia preconditioning by cobalt chloride enhances endurance performance and protects skeletal muscles from exercise-induced oxidative damage in rats.
Topics: Animals; Antioxidants; Cell Hypoxia; Cobalt; Creatine Kinase, MM Form; Cytoprotection; Disease Model | 2010 |
Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.
Topics: Acidosis; Ammonium Chloride; Animals; Blotting, Western; Disease Models, Animal; Gene Expression Reg | 2010 |
Inhibition of acute lung inflammation and injury is a target of brain cooling after heatstroke injury.
Topics: Acute Lung Injury; Animals; Body Temperature Regulation; Brain; Bronchoalveolar Lavage Fluid; Cytoki | 2010 |
Tracheal defect repair using a PLGA-collagen hybrid scaffold reinforced by a copolymer stent with bFGF-impregnated gelatin hydrogel.
Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Cartilage; Collagen; Disease Models, Anim | 2010 |
Evaluation of an injectable rhGDF-5/PLGA construct for minimally invasive periodontal regenerative procedures: a histological study in the dog.
Topics: Absorbable Implants; Alveolar Bone Loss; Animals; Biocompatible Materials; Disease Models, Animal; D | 2010 |
Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion.
Topics: Acidosis, Lactic; Animals; Behavior, Animal; Cell Respiration; Dichloroacetic Acid; Disease Models, | 2010 |
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiati | 2010 |
Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain.
Topics: Analysis of Variance; Animals; Brain; Cold Temperature; Disease Models, Animal; Energy Metabolism; G | 2010 |
Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model.
Topics: Animals; Biocompatible Materials; Collagen; Disease Models, Animal; Drug Combinations; Lactic Acid; | 2010 |
[Effect of sustained release of recombinant rat insulin-like growth factor-1 from poly (lactide-CO-glycolide ) microspheres on bone formation in the peri-implant areas in Goto-Kakizaki rats with type 2 diabetes].
Topics: Animals; Delayed-Action Preparations; Dental Implants; Diabetes Mellitus, Experimental; Diabetes Mel | 2010 |
Long-term neuroprotective effect of postischemic hypothermia in a neonatal rat model of severe hypoxic ischemic encephalopathy: a comparative study on the duration and depth of hypothermia.
Topics: Animals; Animals, Newborn; Body Temperature Regulation; Brain; Diffusion Magnetic Resonance Imaging; | 2010 |
Evaluation of cerebral metabolism by ¹H-magnetic resonance spectroscopy for 4°C saline-induced therapeutic hypothermia in pig model of cardiac arrest.
Topics: Animals; Brain; Cardiac Output; Disease Models, Animal; Female; Heart Arrest; Heart Rate; Hemodynami | 2011 |
Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model.
Topics: Animals; Biocompatible Materials; Cell Movement; Disease Models, Animal; Dogs; Feasibility Studies; | 2010 |
Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies.
Topics: Amnesia; Animals; Biological Transport; Brain; Delayed-Action Preparations; Disease Models, Animal; | 2010 |
Repair of the canine vertebral lamina with a combination of autologous micromorselized bone and poly-lactic acid gel after a total laminectomy.
Topics: Animals; Bone Cements; Bone Transplantation; Disease Models, Animal; Dogs; Female; Humans; Lactic Ac | 2010 |
Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model.
Topics: Animals; Capillaries; Coronary Vessels; Delayed-Action Preparations; Disease Models, Animal; Drug Ca | 2010 |
Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Blood Substitutes; Disease Models, Animal; Dose-Respons | 2011 |
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation Mediators; Lactic Acid; Magn | 2010 |
Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats.
Topics: Animals; Bacteria; Bifidobacterium; Cell Proliferation; Colon; Constipation; Dietary Fiber; Disease | 2010 |
Severe, short-term food restriction improves cardiac function following ischemia/reperfusion in perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Caloric Restriction; Creatine Kinase; D | 2010 |
Antihepatocarcinoma activity of lactic acid bacteria fermented Panax notoginseng.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bacteria; Cell Line, Tumor; Disease Models, Animal; Drug | 2010 |
Venous obstruction and cerebral perfusion during experimental cardiopulmonary bypass.
Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Cardiopulmonary Bypass; Cent | 2010 |
The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction.
Topics: Administration, Oral; Adrenergic Antagonists; Airway Obstruction; Animals; Biomarkers; Blood Glucose | 2010 |
Aerobic capacity of rats recovered from fetal malnutrition with a fructose-rich diet.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Body Weight; Diet, | 2010 |
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion.
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia; | 2010 |
The effective therapy of cyclosporine A with drug delivery system in experimental colitis.
Topics: Administration, Oral; Animals; Biocompatible Materials; Cell Line; Colitis; Cyclosporine; Cytokines; | 2011 |
Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
The effects of 6% hydroxyethyl starch-hypertonic saline in resuscitation of dogs with hemorrhagic shock.
Topics: Acid-Base Equilibrium; Animals; Blood Pressure; Blood Volume; Carbon Dioxide; Disease Models, Animal | 2011 |
Nanofibrous channels: a potential alternative to nerve grafting.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Guided Tissue Regeneration; Lactic Acid; M | 2010 |
High-intensity physical exercise disrupts implicit memory in mice: involvement of the striatal glutathione antioxidant system and intracellular signaling.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; E | 2010 |
A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms.
Topics: Animals; Aorta; Aortic Aneurysm; Biocompatible Materials; Chemokines; Coculture Techniques; Delayed- | 2010 |
Repaglinide-loaded long-circulating biodegradable nanoparticles: rational approach for the management of type 2 diabetes mellitus.
Topics: Administration, Oral; Animals; Blood Glucose; Carbamates; Chemistry, Pharmaceutical; Delayed-Action | 2009 |
Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.
Topics: Animals; Bicarbonates; Chemokine CCL2; Chemokine CCL3; Cholesterol; Disease Models, Animal; Hydrocar | 2011 |
Effects of fluid resuscitation with hypertonic saline dextrane or Ringer's acetate after nonhemorrhagic shock caused by pulmonary contusion.
Topics: Acute Lung Injury; Animals; Blood Pressure; Contusions; Dextrans; Disease Models, Animal; Extravascu | 2010 |
An implantable biochip to influence patient outcomes following trauma-induced hemorrhage.
Topics: Animals; Biosensing Techniques; Disease Models, Animal; Enzymes, Immobilized; Glucose; Glucose Oxida | 2011 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
[A study on blocking effect of polylactic acid patch on intra-discal inflammation after annulus puncture].
Topics: Animals; Discitis; Disease Models, Animal; Female; Inflammation; Interleukin-1beta; Intervertebral D | 2010 |
Periurethral injection of autologous adipose-derived stem cells with controlled-release nerve growth factor for the treatment of stress urinary incontinence in a rat model.
Topics: Adipose Tissue; Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Delayed-Action Preparat | 2011 |
Cerebral arterial gas embolism in swine. Comparison of two sites for air injection.
Topics: Air; Animals; Brain; Cerebral Arterial Diseases; Disease Models, Animal; Embolism, Air; Intracranial | 2011 |
Neuromuscular recovery after medial collateral ligament disruption and eccentric rehabilitation program.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Female; H-Reflex; Hindlimb; Knee Injuries; La | 2011 |
Detection of myocardial ischaemia using surface microdialysis on the beating heart.
Topics: Animals; Biomarkers; Disease Models, Animal; Energy Metabolism; Female; Glucose; Glycerol; Lactic Ac | 2011 |
Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Astrocytes; Behavi | 2011 |
Development of complete thoracic spinal cord transection model in rats for delayed transplantation of stem cells.
Topics: Animals; Disease Models, Animal; Lactic Acid; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid C | 2011 |
Immunization against leishmaniasis by PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and CpG-ODN.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Cytokines; Disease Models, Animal; Drug Carr | 2011 |
Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Basal Metabolism; Body Temperature; Cerebral Arteries; Cerebral Cortex; C | 2011 |
A subunit vaccine based on biodegradable microspheres carrying rHsp65 protein and KLK protects BALB/c mice against tuberculosis infection.
Topics: Adjuvants, Immunologic; Animals; Bacterial Proteins; Chaperonin 60; Disease Models, Animal; Drug Del | 2010 |
Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant.
Topics: Animals; CD8-Positive T-Lymphocytes; Disease Models, Animal; Freund's Adjuvant; Immunotherapy; Lacti | 2011 |
Impact of early fructose intake on metabolic profile and aerobic capacity of rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weights and Measures; Dietary Carbohydrates; Disease Mo | 2011 |
Stable mixed acidemia in anesthetized pigs--a model for research on biocompatibility of hemofilters under a deteriorated acid-base balance.
Topics: Acidosis; Animals; Disease Models, Animal; Hemofiltration; Hydrochloric Acid; Lactic Acid; Male; Mat | 2011 |
NEL-like molecule-1-modified bone marrow mesenchymal stem cells/poly lactic-co-glycolic acid composite improves repair of large osteochondral defects in mandibular condyle.
Topics: Animals; Cartilage, Articular; Collagen Type II; Disease Models, Animal; Goats; Immunohistochemistry | 2011 |
Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cardiac Output; Creatinine; Disease Models, Anima | 2011 |
Rat sciatic nerve repair with a poly-lactic-co-glycolic acid scaffold and nerve growth factor releasing microspheres.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Female; Lactic Acid; Microspheres; Nerve G | 2011 |
Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy.
Topics: Animals; Arthritis, Experimental; Biomarkers; Carbon Isotopes; Contrast Media; Disease Models, Anima | 2011 |
Pharmacological evaluation of Potentilla alba L. in mice: adaptogenic and central nervous system effects.
Topics: Adaptation, Psychological; Animals; Anti-Anxiety Agents; Behavior, Animal; Blood Glucose; Body Weigh | 2011 |
Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.
Topics: Acetaminophen; Amino Acids; Animals; Biomarkers; Citric Acid Cycle; Disease Models, Animal; Gluconeo | 2011 |
Magnesium does not influence the clinical course of succinylcholine-induced malignant hyperthermia.
Topics: Animals; Biomarkers; Carbon Dioxide; Disease Models, Animal; Energy Metabolism; Hemodynamics; Hydrog | 2011 |
Changes in the lactate threshold during treadmill exercise after microsphere-induced infarction in rats.
Topics: Anaerobic Threshold; Animals; Behavior, Animal; Carotid Artery, Internal; Cerebral Infarction; Disea | 2012 |
Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2.
Topics: Animals; Bone Diseases; Bone Morphogenetic Protein 2; Bone Regeneration; Collagen; Disease Models, A | 2011 |
Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs.
Topics: Animals; Biomarkers; Chemistry, Pharmaceutical; Dantrolene; Disease Models, Animal; Halothane; Hemod | 2011 |
The impact of deep and moderate body temperatures on end-organ function during hypothermic circulatory arrest.
Topics: Animals; Biomarkers; Body Temperature; Carbon Dioxide; Cardiopulmonary Bypass; Cerebrovascular Circu | 2011 |
Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; | 2011 |
A model of hemorrhagic shock and acute lung injury in Landrace-Large White Swine.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Heart Rate; Hemoglobins; Hydrogen-Ion Concentrat | 2011 |
Comparison of long-acting bevacizumab formulations in the treatment of choroidal neovascularization in a rat model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz | 2011 |
Rabbit rubeosis iridis induced by intravitreal latex-derived angiogenic fraction.
Topics: Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Disease Progression; Drug Carriers; F | 2011 |
Intravitreally implantable voriconazole delivery system for experimental fungal endophthalmitis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Deliv | 2011 |
Novel technique of overlaying a poly-L: -lactic acid nanosheet for adhesion prophylaxis and fixation of intraperitoneal onlay polypropylene mesh in a rabbit model.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Hernia, Abdominal; Lactic Acid; Polyesters | 2011 |
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
Topics: Animals; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Female; Gene Deletion; Gen | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Transplantation of artificial neural construct partly improved spinal tissue repair and functional recovery in rats with spinal cord transection.
Topics: Animals; Animals, Newborn; Biotin; Cell Count; Cells, Cultured; Dextrans; Disease Models, Animal; Di | 2011 |
Enhanced efficacy of sirolimus-eluting bioabsorbable magnesium alloy stents in the prevention of restenosis.
Topics: Alloys; Angioplasty; Animals; Aorta, Abdominal; Aortic Diseases; Arterial Occlusive Diseases; Cardio | 2011 |
Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Combinations; D | 2011 |
Using microdialysis for early detection of vascular thrombosis after kidney transplantation in an experimental porcine model.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Blood Glucose; Disease Models, Animal; Ea | 2012 |
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Topics: Animals; Antineoplastic Agents; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Coumaric Ac | 2011 |
Microdialysis detection of lactate in subcutaneous tissue as a reliable indicator of tissue metabolic disorders in an animal sepsis model.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Lactic Acid; Lipopolysaccharides; Male; Microdi | 2011 |
Biochemical and pathological evidences on the benefit of a new biodegradable nanoparticles of probiotic extract in murine colitis.
Topics: Animals; Chitosan; Colitis; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relation | 2012 |
An effective novel delivery strategy of rasagiline for Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Brain; Delayed-Action Preparations; Disease Models, Animal; Fluorodeo | 2011 |
Antimycobacterial activity of 2-phenoxy-1-phenylethanone, a synthetic analogue of neolignan, entrapped in polymeric microparticles.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Disease Models, Animal; Drug Carriers; Drug | 2012 |
Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.
Topics: Animals; Blood Urea Nitrogen; Cell Proliferation; Disease Models, Animal; Drugs, Chinese Herbal; Fat | 2012 |
Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata.
Topics: Adenosine Triphosphate; Alkanes; Altitude Sickness; Animals; Blood Glucose; Brain; Ca(2+) Mg(2+)-ATP | 2011 |
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; | 2011 |
Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress.
Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Brain; Chelating Agents; Disease Models, Animal; | 2011 |
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; As | 2011 |
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
Topics: Acetylcysteine; Alanine; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Free Radic | 2012 |
Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Evoked Po | 2011 |
PLA/ β-TCP complex tubes: the mechanical properties and applications of artificial bone.
Topics: Animals; Bone Regeneration; Bone Substitutes; Calcium Phosphates; Cell Line, Tumor; Cell Survival; C | 2012 |
Effect of short-term ornithine alpha-ketoglutarate pretreatment on intestinal ischemia-reperfusion in rats.
Topics: Animals; Calcium Carbonate; Disease Models, Animal; Intestinal Diseases; Intestine, Small; Ischemia; | 2011 |
Preconditioning with L-alanyl-L-glutamine in a Mongolian gerbil model of acute cerebral ischemia/reperfusion injury.
Topics: Animals; Blood Glucose; Brain Ischemia; Dipeptides; Disease Models, Animal; Gerbillinae; Ischemic Pr | 2011 |
Electroacupuncture stimulation using different frequencies (10 and 100 Hz) changes the energy metabolism in induced hyperglycemic rats.
Topics: Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Energy Metabolism; Hypergly | 2011 |
Cerebral metabolism after early decompression craniotomy following controlled cortical impact injury in rats.
Topics: Animals; Brain Injuries; Cerebral Cortex; Craniotomy; Decompression, Surgical; Disease Models, Anima | 2011 |
Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery.
Topics: Animals; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Endophthalmitis; Female | 2011 |
Beneficial effect of hypertonic saline resuscitation in a porcine model of severe acute pancreatitis.
Topics: Acute Disease; Animals; Biomarkers; Creatinine; Disease Models, Animal; Enzymes; Female; Hemodynamic | 2012 |
Assessment of aerobic capacity during swimming exercise in ob/ob mice.
Topics: Animals; Disease Models, Animal; Exercise Therapy; Humans; Lactic Acid; Male; Mice; Mice, Inbred C57 | 2011 |
Bone screws have advantages in repair of experimental osteochondral fragments.
Topics: Animals; Biomechanical Phenomena; Bone Regeneration; Bone Screws; Cartilage, Articular; Cattle; Dise | 2012 |
Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug S | 2011 |
The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Glucose; Blood Pressure; Disease M | 2012 |
Biodegradable nanoparticles mimicking platelet binding as a targeted and controlled drug delivery system.
Topics: Adhesiveness; Animals; Carotid Artery Injuries; Cells, Cultured; Chemistry, Pharmaceutical; Computer | 2012 |
Locally infused gene containg nanoparticles to inhibit rabbit intimal hyperplasia.
Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Injuries; Chemokine CCL2; Disease Mo | 2011 |
Cerebrospinal fluid biochemistry reflects effects of therapeutic hypothermia after cardiac arrest in a porcine model.
Topics: Animals; Body Temperature; Disease Models, Animal; Glucose; Glutamic Acid; Glycerol; Heart Arrest; H | 2012 |
[Neuroprotector effect of human recombinant erythropoietin sorbed on polymer nanoparticles studied on model of intracerebral post-traumatic hematoma (hemorrhagic stroke)].
Topics: Adsorption; Amnesia; Animals; Cerebral Hemorrhage; Disease Models, Animal; Enbucrilate; Erythropoiet | 2011 |
The effect of long-term release of Shh from implanted biodegradable microspheres on recovery from spinal cord injury in mice.
Topics: Animals; Astrocytes; Biodegradation, Environmental; Cell Proliferation; Delayed-Action Preparations; | 2012 |
Bioevaluation study of 32P-CP-PLLA particle brachytherapy in a rabbit VX2 lung tumor model.
Topics: Animals; Brachytherapy; Disease Models, Animal; Fluorodeoxyglucose F18; Lactic Acid; Lung Neoplasms; | 2012 |
Increased circulating D-lactate levels predict risk of mortality after hemorrhage and surgical trauma in baboons.
Topics: Animals; Colon; Disease Models, Animal; Humans; Ischemia; Lactic Acid; Male; Papio ursinus; Risk Fac | 2012 |
Surface microdialysis sampling: a new approach described in a liver ischaemia model.
Topics: Animals; Disease Models, Animal; Energy Metabolism; Female; Glucose; Glycerol; Ischemia; Lactic Acid | 2012 |
Ischaemic preconditioning reduces myocardial calcium overload in coronary-occluded pig hearts shown by continuous in vivo assessment using microdialysis.
Topics: Animals; Biomarkers; Calcium; Calcium Ionophores; Calcium Radioisotopes; Cells, Cultured; Coronary O | 2012 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
[Effects of acetoacetate extract of Radix Aconite on hepatic contents of LA, LDH, PA, Gn and ATPase activities in deficient cold model rats].
Topics: Acetoacetates; Adenosine Triphosphatases; Animals; Disease Models, Animal; Diterpenes; Drugs, Chines | 2011 |
Novel diagnostics of metabolic dysfunction detected in breath and plasma by selective isotope-assisted labeling.
Topics: Aluminum Oxide; Animals; Blood Glucose; Breath Tests; Carbon Isotopes; Disease Models, Animal; Drug | 2012 |
Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage.
Topics: Animals; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; G | 2012 |
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Delayed-Action Preparations; Disease Models, Anima | 2012 |
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography.
Topics: Animals; Arterial Pressure; Atropine; Blood Gas Analysis; Brain Death; Cardiac Output; Cerebral Angi | 2012 |
Rapid-prototyped PLGA/β-TCP/hydroxyapatite nanocomposite scaffolds in a rabbit femoral defect model.
Topics: Animals; Bone Regeneration; Bone Substitutes; Calcium Phosphates; Disease Models, Animal; Durapatite | 2012 |
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
Topics: Animals; Autonomic Nervous System; Blood Pressure; Catecholamines; Cytokines; Disease Models, Animal | 2012 |
Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study.
Topics: Ammonia; Animals; Bilirubin; Biomarkers; Cerebrovascular Circulation; Disease Models, Animal; Equipm | 2012 |
Oxygen breathing affects 3'-deoxy-3'-18F-fluorothymidine uptake in mouse models of arthritis and cancer.
Topics: Anesthesia; Animals; Ankle; Arthritis; Artifacts; Biological Transport; Carbon Dioxide; Cell Line, T | 2012 |
Improvement of intertrochanteric bone quality in osteoporotic female rats after injection of polylactic acid-polyglycolic acid copolymer/collagen type I microspheres combined with bone mesenchymal stem cells.
Topics: Animals; Bone Density; Bone Marrow Cells; Coated Materials, Biocompatible; Collagen Type I; Disease | 2012 |
Regeneration of the periodontium using enamel matrix derivative in combination with an injectable bone cement.
Topics: Alveolar Bone Loss; Animals; Bone Cements; Bone Regeneration; Bone Substitutes; Calcium Phosphates; | 2013 |
Vaccine potential of cytosolic proteins loaded fibrin microspheres of Cryptococcus neoformans in BALB/c mice.
Topics: Animals; Antigens, Fungal; Cryptococcosis; Cryptococcus neoformans; Cytokines; Cytosol; Disease Mode | 2012 |
Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis.
Topics: Acrylic Resins; Animals; Cardiac Catheters; Cardiovascular Agents; Chemistry, Pharmaceutical; Corona | 2013 |
One-step articular cartilage repair: combination of in situ bone marrow stem cells with cell-free poly(L-lactic-co-glycolic acid) scaffold in a rabbit model.
Topics: Animals; Arthroplasty, Subchondral; Bone Marrow Cells; Cartilage, Articular; Cell Differentiation; C | 2012 |
Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels.
Topics: Animals; Anti-Allergic Agents; Caco-2 Cells; Cell Line; Dermatitis, Atopic; Disease Models, Animal; | 2012 |
Early detection of subclinical organ dysfunction by microdialysis of the rectus abdominis muscle in a porcine model of critical intra-abdominal hypertension.
Topics: Animals; Disease Models, Animal; Intra-Abdominal Hypertension; Lactic Acid; Male; Microdialysis; Pyr | 2012 |
Protective effects of saizen in combination with stilamin on intestinal mucosa of a rabbit model of severe acute pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Biomarkers; Caspase 3; Cytoprotection; Disease Models, Animal; Dr | 2013 |
Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Computer Simulation; Dichloroacetic Acid | 2012 |
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Brain Neoplasms; Cell Cycle Che | 2013 |
Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Ceftriaxone; Cells, Cultured; Dentate Gyrus; | 2012 |
Infusing sodium bicarbonate suppresses hydrogen peroxide accumulation and superoxide dismutase activity in hypoxic-reoxygenated newborn piglets.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Animals, Newborn; Blood Gas Analysis; Catalase; Cerebral C | 2012 |
Parental diet-induced obesity leads to retarded early mouse embryo development and altered carbohydrate utilisation by the blastocyst.
Topics: Adiposity; Animals; Blastocyst; Carbohydrate Metabolism; Cell Cycle; Diet, High-Fat; Disease Models, | 2012 |
Oligodendroglia metabolically support axons and contribute to neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Cell Line; Cell Survival; Disease Models, Animal; Dow | 2012 |
Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair.
Topics: Animals; Bone Marrow Cells; Calcium Phosphates; Cells, Cultured; Disease Models, Animal; Femoral Fra | 2013 |
Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCs.
Topics: Animals; Apoptosis; Biocompatible Materials; Cell Survival; Cells, Cultured; Delayed-Action Preparat | 2012 |
Effects of local delivery of bFGF from PLGA microspheres on osseointegration around implants in diabetic rats.
Topics: Animals; Biocompatible Materials; Dental Implants; Dental Materials; Diabetes Mellitus, Experimental | 2012 |
Novel modification of an artificial placenta: pumpless arteriovenous extracorporeal life support in a premature lamb model.
Topics: Animals; Arterial Pressure; Artificial Organs; Disease Models, Animal; Dopamine; Equipment Design; E | 2012 |
Development and preclinical evaluation of a biodegradable ventricular septal defect occluder.
Topics: Absorbable Implants; Animals; Cardiac Catheterization; Disease Models, Animal; Dogs; Feasibility Stu | 2013 |
Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antioxidants; beta Carotene; Brain; Calorimetry, Dif | 2012 |
A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids.
Topics: Acyltransferases; Administration, Oral; Alginates; Animals; Blindness; Delayed-Action Preparations; | 2012 |
Identification of a lactate-quinone oxidoreductase in Staphylococcus aureus that is essential for virulence.
Topics: Animals; Bacterial Proteins; Disease Models, Animal; Genes, Bacterial; Host-Pathogen Interactions; H | 2011 |
Metabolomic markers for intestinal ischemia in a mouse model.
Topics: Animals; Biomarkers; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Intestines; Ische | 2012 |
Reliable porcine coronary model of chronic total occlusion using copper wire stents and bioabsorbable levo-polylactic acid polymer.
Topics: Animals; Biocompatible Materials; Chronic Disease; Copper; Coronary Occlusion; Coronary Vessels; Dis | 2012 |
Hepatic and abdominal carbon dioxide measurements detect and distinguish hepatic artery occlusion and portal vein occlusion in pigs.
Topics: Animals; Arterial Occlusive Diseases; Biomarkers; Blood Gas Analysis; Carbon Dioxide; Constriction, | 2012 |
Ligament regeneration using an absorbable stent-shaped poly-L-lactic acid scaffold in a rabbit model.
Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Collagen Type I; Disease Models, Animal; | 2012 |
Comparison of early fibrovascular proliferation according to orbital implant in orbital floor fracture reconstruction.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Disease Models, Animal; Fibroblast Growth Fac | 2012 |
Effects of glutamine treatment on myocardial damage and cardiac function in rats after severe burn injury.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Aspartate Aminotransferases; Biomarkers; Burn | 2012 |
Controlled release of rasagiline mesylate promotes neuroprotection in a rotenone-induced advanced model of Parkinson's disease.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Line, Tumor; Delayed-Action Preparations; Disease Models, | 2012 |
Introduction of a high-throughput double-stent animal model for the evaluation of biodegradable vascular stents.
Topics: Absorbable Implants; Animals; Aorta, Abdominal; Blood Vessel Prosthesis; Blood Vessel Prosthesis Imp | 2012 |
[In vivo degradable properties of a novel injectable calcium phosphate cement containing poly lactic-co-glycolic acid].
Topics: Animals; Biocompatible Materials; Bone Cements; Calcium Phosphates; Disease Models, Animal; Female; | 2012 |
[Neuroprotective effect of recombinant human erythropoietin-loaded poly(lactic-co-glycolic) acid nanoparticles in rats with intracerebral posttraumatic hematoma].
Topics: Amnesia; Animals; Avoidance Learning; Cerebral Hemorrhage, Traumatic; Disease Models, Animal; Drug C | 2012 |
Effects of glycine supplementation on myocardial damage and cardiac function after severe burn.
Topics: Adenosine Triphosphate; Alanine; Analysis of Variance; Animals; Aspartate Aminotransferases; Biomark | 2013 |
Shaking stress aggravates burn-induced cardiovascular and renal disturbances in a rabbit model.
Topics: Animals; Blood Urea Nitrogen; Burns; Cardiovascular Diseases; Creatinine; Disease Models, Animal; Fl | 2013 |
Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats.
Topics: Absorbable Implants; Animals; Anticonvulsants; Disease Models, Animal; Drug Delivery Systems; Electr | 2013 |
Correlation of arterial fetal base deficit and lactate changes with severity of variable heart rate decelerations in the near-term ovine fetus.
Topics: Acidosis; Animals; Disease Models, Animal; Female; Fetal Hypoxia; Fetal Monitoring; Fetus; Heart Rat | 2013 |
A syndrome of severe hypoglycemia and acidosis in young immunosuppressed diabetic monkeys and pigs-association with sepsis.
Topics: Acidosis; Animals; Bacteria; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2012 |
Newly designed bioabsorbable substitute for the treatment of diaphragmatic defects.
Topics: Absorbable Implants; Animals; Caproates; Diaphragm; Disease Models, Animal; Hernia, Diaphragmatic; H | 2013 |
Methyl-isobutyl amiloride reduces brain Lac/NAA, cell death and microglial activation in a perinatal asphyxia model.
Topics: Amiloride; Animals; Aspartic Acid; Asphyxia; Brain; Cell Death; Disease Models, Animal; Hypoxia-Isch | 2013 |
Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models.
Topics: Age Factors; Animals; Animals, Newborn; Biotin; Chronic Disease; Dextrans; Disease Models, Animal; E | 2013 |
Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats.
Topics: Animals; Antiparkinson Agents; Benserazide; Blotting, Western; Delayed-Action Preparations; Disease | 2012 |
Assessment of maximal lactate steady state during treadmill exercise in SHR.
Topics: Animals; Biomarkers; Disease Models, Animal; Exercise Therapy; Female; Hypertension; Lactic Acid; Mu | 2012 |
Survivorship of implanted bone marrow-derived mesenchymal stem cells in acute rotator cuff tear.
Topics: Animals; Cell Survival; Collagen Type I; Collagen Type II; Disease Models, Animal; Guided Tissue Reg | 2013 |
Methylene blue protects liver oxidative capacity after gut ischaemia-reperfusion in the rat.
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Biomarkers; Cytoprotection; D | 2013 |
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.
Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution | 2012 |
Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis.
Topics: Alginates; Animals; Apoptosis; Disease Models, Animal; Drug Carriers; Drug Combinations; Femoral Art | 2013 |
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia.
Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin | 2013 |
A new drug delivery system inhibits uveitis in an animal model after cataract surgery.
Topics: Animals; Anti-Inflammatory Agents; Biocompatible Materials; Cataract Extraction; Cyclosporine; Disea | 2013 |
Effects of monoamine reuptake inhibitors in assays of acute pain-stimulated and pain-depressed behavior in rats.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Biophysics; Conditioning, Operant; Depression; | 2013 |
A 24-h pneumoperitoneum leads to multiple organ impairment in a porcine model.
Topics: Alkaline Phosphatase; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Compartment | 2002 |
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Carbon Isotopes; Carbon Radioisotopes; Carb | 2002 |
Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Chromatography, High Pressure Liquid; Delayed | 2002 |
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.
Topics: Acetanilides; Animals; Cardiotonic Agents; Chronic Disease; Coronary Circulation; Disease Models, An | 2002 |
Cerebral physiological and biochemical changes during vasogenic brain oedema induced by intrathecal injection of bacterial lipopolysaccharides in piglets.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Escherichia coli; Glucose; Inflammation; Intrac | 2002 |
Effect of intra-aortic occlusion balloon in external thoracic compressions during CPR in pigs.
Topics: Animals; Blood Gas Analysis; Breath Tests; Capnography; Carbon Dioxide; Cardiac Output; Cardiopulmon | 2002 |
Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS.
Topics: Animals; Biomarkers; Breast Neoplasms; Carbon Isotopes; Disease Models, Animal; Female; Glucose; Gly | 2002 |
Compartmentalized bone regeneration of cranial defects with biodegradable barriers--effects of calcium sodium phosphate surface coatings on LactoSorb.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Diseases; Bone Regeneration; Calcium Pho | 2002 |
Blood pH level modulates organ metabolism of lactate in septic shock in dogs.
Topics: Animals; Bacteremia; Blood Gas Analysis; Disease Models, Animal; Dogs; Escherichia coli Infections; | 2002 |
Low-dose ethanol alters the cardiovascular, metabolic, and respiratory compensation for severe blood loss.
Topics: Alcoholic Intoxication; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Disease Models, Anim | 2002 |
Variable effects of short chain fatty acids and lactic acid in inducing intestinal mucosal injury in newborn rats.
Topics: Acetic Acid; Animals; Animals, Newborn; Butyric Acid; Colon; Disease Models, Animal; Dose-Response R | 2002 |
Tissue welding with biodegradable polymer films-demonstration of acute strength reinforcement in vivo.
Topics: Animals; Biocompatible Materials; Dermatologic Surgical Procedures; Disease Models, Animal; In Vitro | 2002 |
Intraperitoneal microdialysis for detection of splanchnic metabolic disorders.
Topics: Animals; Ascitic Fluid; Cryoprotective Agents; Disease Models, Animal; Extracellular Space; Gastroin | 2002 |
Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock.
Topics: Animals; Cytokines; Disease Models, Animal; Isotonic Solutions; Lactic Acid; Lipopolysaccharides; Ma | 2002 |
[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells].
Topics: Adenocarcinoma; Animals; Cell Cycle; Cell Division; Disease Models, Animal; DNA, Antisense; Humans; | 2002 |
Application of poly-lactide-co-glycolide-microspheres in the transarterial chemoembolization in an animal model of hepatocellular carcinoma.
Topics: Animals; Antibiotics, Antineoplastic; Arteries; Carcinoma, Hepatocellular; Chemoembolization, Therap | 2003 |
Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Fatty Acids, Nonesterified; Glycogen; Glycoly | 2003 |
Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest.
Topics: Adaptation, Physiological; Adrenergic beta-Agonists; Animals; Blood Flow Velocity; Blood Pressure; C | 2003 |
Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Hexosyltransferases; Lactic Aci | 2003 |
Effects of epinephrine and norepinephrine on hemodynamics, oxidative metabolism, and organ energetics in endotoxemic rats.
Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Gas Analysis; Diseas | 2003 |
Preliminary biocompatibility experiment of polymer films for laser-assisted tissue welding.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Female; Lactic Acid; Laser Coagulation; Ma | 2003 |
Enhanced peripheral nerve regeneration elicited by cell-mediated events delivered via a bioresorbable PLGA guide.
Topics: Animals; Biocompatible Materials; Cell Movement; Disease Models, Animal; Female; Immunohistochemistr | 2003 |
Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus.
Topics: Acetates; Animals; Astrocytes; Biomarkers; Brain Stem; Carbon Isotopes; Disease Models, Animal; Dise | 2003 |
Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin.
Topics: Acidosis, Lactic; Animals; Biguanides; Disease Models, Animal; DNA-Binding Proteins; Hepatocytes; Ho | 2003 |
Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs.
Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium; Creatine Kinase; Creatine Kinase, MB Form; Diseas | 2003 |
Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs.
Topics: Animals; Blood Gas Analysis; Capillary Leak Syndrome; Disease Models, Animal; Echocardiography; Func | 2003 |
Left ventricular support by catheter-mounted axial flow pump reduces infarct size.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Cardiac Surgical Procedures; Disease Mo | 2003 |
PLGA microspheres for oral osteopenia treatment: preliminary "in vitro"/"in vivo" evaluation.
Topics: Animals; Bone Remodeling; Disease Models, Animal; Drug Carriers; Drug Compounding; Female; Injection | 2003 |
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Topics: Animals; Behavior, Animal; Corpus Striatum; Creatine; Disease Models, Animal; Dizocilpine Maleate; D | 2003 |
Do rapid systemic changes of brain temperature have an influence on the brain?
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Cerebrovascular Circulation; Disease Models, Anim | 2003 |
Experimental study of LY333328 (oritavancin), alone and in combination, in therapy of cephalosporin-resistant pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Ceftriaxone; Cephalosporin | 2003 |
Resuscitation with a novel hemoglobin-based oxygen carrier in a Swine model of uncontrolled perioperative hemorrhage.
Topics: Animals; Blood Cell Count; Blood Loss, Surgical; Disease Models, Animal; Electroencephalography; Hem | 2003 |
Intraperitoneal microdialysis (IPM): a new technique for monitoring intestinal ischemia studied in a porcine model.
Topics: Animals; Catheterization; Disease Models, Animal; Female; Glucose; Glycerol; Intestinal Mucosa; Inte | 2003 |
Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.
Topics: Amino Acids; Animals; Brain Edema; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral | 2003 |
Effects of sustained post-traumatic shock and initial fluid resuscitation on extravascular lung water content and pulmonary vascular pressures in a porcine model of shock.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Extravascular Lung Water; Female; F | 2003 |
Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function.
Topics: Age Factors; Animals; Biological Transport; Biomarkers; Disease Models, Animal; Female; Glucose-6-Ph | 2003 |
Attempt to establish an experimental animal model of moyamoya disease using immuno-embolic material--histological changes of the arterial wall resulting from immunological reaction in cats.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Carotid Arteries; Carotid Artery | 2003 |
Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Erythrocytes; Free Radical Scavengers; Infusion | 2003 |
Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep.
Topics: Animals; Asphyxia; Blood Gas Analysis; Body Temperature; Brain; Calorimetry; Cell Count; Cerebrovasc | 2003 |
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness.
Topics: Alloxan; Animals; Blood Gas Analysis; Blood Glucose; Body Weight; Burns; Critical Illness; Diabetes | 2003 |
Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart.
Topics: Animals; Brain Death; Coronary Circulation; Disease Models, Animal; Dogs; Hemodynamics; Lactic Acid; | 2003 |
Restoration of sarcoplasmic reticulum protein level by thyroid hormone contributes to partial improvement of myocardial function, but not to glucose metabolism in an early failing heart.
Topics: Animals; Calcium-Transporting ATPases; Cells, Cultured; Disease Models, Animal; Disease Progression; | 2003 |
The effects of dichloroacetate in a rabbit model of acute hind-limb ischemia and reperfusion.
Topics: Animals; Dichloroacetic Acid; Disease Models, Animal; Female; Hindlimb; Ischemia; Lactic Acid; Muscl | 2003 |
Subchondral bone reaction associated with chondral defect and attempted cartilage repair in goats.
Topics: Animals; Arthroscopy; Biocompatible Materials; Bioprosthesis; Biopsy; Caproates; Cartilage Diseases; | 2004 |
Defect repair in the rat mandible with bone morphogenic protein 5 and prostaglandin E1.
Topics: Alprostadil; Animals; Biocompatible Materials; Bone Morphogenetic Protein 5; Bone Morphogenetic Prot | 2003 |
Antihyperalgesic effect of simultaneously released hydromorphone and bupivacaine from polymer fibers in the rat chronic constriction injury model.
Topics: Analgesics, Opioid; Animals; Bupivacaine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2003 |
Scleral plug of biodegradable polymers containing tacrolimus (FK506) for experimental uveitis.
Topics: Absorbable Implants; Animals; Antigens, Bacterial; Aqueous Humor; Biocompatible Materials; Cell Coun | 2003 |
Periocular injection of microspheres containing PKC412 inhibits choroidal neovascularization in a porcine model.
Topics: Animals; Biocompatible Materials; Biological Availability; Bruch Membrane; Choroid; Choroidal Neovas | 2003 |
Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3.
Topics: Animals; Ataxin-3; Brain; Cerebellum; Choline; Disease Models, Animal; gamma-Aminobutyric Acid; Gluc | 2004 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
Experimental evaluation of the influence of complete artificial circulation on renal circulation and tissue metabolism -comparative study of pulsatile vs nonpulsatile circulation.
Topics: Analysis of Variance; Animals; beta 2-Microglobulin; Blood Urea Nitrogen; Creatinine; Disease Models | 2003 |
Effects of intraaortic balloon augmentation in a porcine model of endotoxemic shock.
Topics: Animals; Disease Models, Animal; Female; Intra-Aortic Balloon Pumping; Lactic Acid; Male; Prospectiv | 2004 |
Preincubation of tissue engineered constructs enhances donor cell retention.
Topics: Animals; Cartilage, Articular; Cell Count; Cell Culture Techniques; Cell Survival; Chondrocytes; Dis | 2004 |
Metabolism of 13C-enriched D-fructose in hepatocytes from Goto-Kakizaki rats.
Topics: Alanine; Animals; Buffers; Carbon Isotopes; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Mode | 2004 |
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
Topics: Animals; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Guanidines; Huntingt | 2004 |
Mild hypothermia protects the spinal cord from ischemic injury in a chronic porcine model.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Evoked Potentials, Motor; Female; Hypothermia, Ind | 2004 |
Effect of amino acid mixture on the isolated ischemic heart.
Topics: Adenosine Triphosphate; Administration, Oral; Amino Acids, Essential; Animals; Creatine Kinase; Diet | 2004 |
A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI.
Topics: Animals; Animals, Newborn; Aspartic Acid; Basal Ganglia; Cerebral Cortex; Cerebrovascular Circulatio | 2004 |
Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Cefazolin; Disease Models, Animal; Drug Car | 2004 |
Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets.
Topics: Animals; Animals, Newborn; Asphyxia; Blood Pressure; Carbon Dioxide; Cerebral Cortex; Cerebrovascula | 2004 |
Enhancement of bone volume in guided bone augmentation by cell transplants derived from periosteum: an experimental study in rabbit calvarium bone.
Topics: Alkaline Phosphatase; Animals; Biocompatible Materials; Bone Diseases; Bone Regeneration; Calcificat | 2004 |
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.
Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode | 2004 |
Effects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma.
Topics: Adjuvants, Anesthesia; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Glucos | 2004 |
[Change in intestinal function in sepsis in rat].
Topics: Amine Oxidase (Copper-Containing); Animals; Disease Models, Animal; Intestines; Ischemia; Lactic Aci | 2004 |
Potentiation by amino acid of the therapeutic effect of highly purified vitamin B2 in mice with lipopolysaccharide-induced shock.
Topics: Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Escherichia coli; Glucos | 2004 |
[Effects of acidic fibroblast growth factor on intestinal mucosal damage due to ischemia/reperfusion].
Topics: Animals; Disease Models, Animal; Fibroblast Growth Factor 1; Intestinal Mucosa; Lactic Acid; Random | 2004 |
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, A | 2004 |
Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Blood-Br | 2004 |
Functional magnetic ventilation in dogs.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Carbon Dioxide; Cervical Vertebrae; Disease Model | 2004 |
Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results.
Topics: Animals; Computer Simulation; Coronary Circulation; Disease Models, Animal; Energy Metabolism; Glyco | 2004 |
Interaction with antigen-specific T cells regulates expression of the lactate transporter MCT1 in primary rat astrocytes: specific link between immunity and homeostasis.
Topics: Adoptive Transfer; Animals; Antibodies; Antigen-Presenting Cells; Antigens, CD; Astrocytes; Basigin; | 2005 |
Microdialysis analyzer and flame atomic absorption spectrometry in the determination of blood glucose, lactate and magnesium in gerbils subjected to cerebral ischemia/reperfusion.
Topics: Animals; Area Under Curve; Blood Glucose; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Disease | 2004 |
New approach to an ovine model of hypodynamic endotoxaemia.
Topics: Animals; Bacterial Toxins; Body Temperature; Carbon Dioxide; Cardiac Output; Disease Models, Animal; | 2004 |
An in-vivo model to interrogate the transition from acute to chronic inflammation.
Topics: Absorbable Implants; Acute Disease; Animals; Calcium Phosphates; Chronic Disease; Coated Materials, | 2004 |
Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration.
Topics: Administration, Oral; Alanine; Animals; Arabinose; Blood Glucose; Chlorogenic Acid; Diabetes Mellitu | 2005 |
Poly-ADP-ribose polymerase inhibition reduces mesenteric injury after cardiopulmonary bypass.
Topics: Acetylcholine; Animals; Cardiopulmonary Bypass; Creatine Kinase; Disease Models, Animal; Dogs; Endot | 2004 |
On-line monitoring of striatum glucose and lactate in the endothelin-1 rat model of transient focal cerebral ischemia using microdialysis and flow-injection analysis with biosensors.
Topics: Animals; Biosensing Techniques; Cerebral Infarction; Cerebrovascular Circulation; Corpus Striatum; D | 2004 |
Trimetazidine protects isolated rat hearts against ischemia-reperfusion injury in an experimental timing-dependent manner.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Drug Administration Schedule; In Vitro Techniqu | 2005 |
[Protective effects of modified recombinant human acidic fibroblast growth factor on small intestine after ischemia/reperfusion injury in rats].
Topics: Animals; Apoptosis; Disease Models, Animal; Epithelial Cells; Fibroblast Growth Factor 1; Humans; In | 2005 |
In vivo experimental study on bone regeneration in critical bone defects using an injectable biodegradable PLA/PGA copolymer.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Diseases; Bone Regeneration; Bone Substi | 2005 |
Preventing intra-abdominal adhesions with polylactic acid film: an animal study.
Topics: Abdomen; Animals; Biocompatible Materials; Cecum; Disease Models, Animal; Female; Lactic Acid; Membr | 2005 |
[Protective effects of acidic fibroblast growth factor on intestinal ischemia/reperfusion in rats].
Topics: Animals; Disease Models, Animal; Fibroblast Growth Factor 1; Humans; Intestines; Lactic Acid; Male; | 2005 |
Subcutaneous gas tensions closely track ileal mucosal gas tensions in a model of endotoxaemia without anaerobism.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Il | 2005 |
[The research of assembling animal models of keloid employing the method of tissue engineering].
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Female; Fibroblasts; Humans; Keloid; Lactic | 2005 |
The haemodynamic and metabolic effects of epinephrine in experimental hyperdynamic septic shock.
Topics: Animals; Disease Models, Animal; Epinephrine; Escherichia coli Infections; Female; Hemodynamics; Inf | 2005 |
Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis.
Topics: Animals; Blood Glucose; Brain Ischemia; Cats; Cortical Spreading Depression; Disease Models, Animal; | 2005 |
Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Bone Cements; Ciprofloxacin; Coated Materials, Biocompatible; Diseas | 2005 |
[Protection of rat heart myocardium with a selective Na(+)/H(+) exchange inhibitor and ischemic preconditioning].
Topics: Adenosine Triphosphate; Animals; Cation Transport Proteins; Disease Models, Animal; Guanidines; Inje | 2005 |
Polyglycolic acid/poly-L-lactic acid copolymer use in laryngotracheal reconstruction: a rabbit model.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Cartilage; Disease Models, Animal; Female; Gl | 2005 |
New generation of hemoglobin-based oxygen carriers evaluated for oxygenation of critically ischemic hamster flap tissue.
Topics: Animals; Blood Substitutes; Carbohydrate Metabolism; Cattle; Cricetinae; Critical Illness; Disease M | 2005 |
Resuscitation from experimental heatstroke by hyperbaric oxygen therapy.
Topics: Animals; Biomarkers; Brain Diseases; Disease Models, Animal; Glutamic Acid; Glycerol; Heat Stroke; H | 2005 |
Effects of hyperbaric treatment in cerebral air embolism on intracranial pressure, brain oxygenation, and brain glucose metabolism in the pig.
Topics: Animals; Brain; Brain Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Electroenc | 2005 |
Increases in both buccal and sublingual partial pressure of carbon dioxide reflect decreases of tissue blood flows in a porcine model during hemorrhagic shock.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Cheek; Disease Models, Animal; Kidney; Lact | 2005 |
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy.
Topics: Alanine; Amino Acids; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Carbon Radioisotopes; | 2005 |
Effects of cocaine in an experimental model of traumatic brain injury.
Topics: Animals; Blood Pressure; Brain Injuries; Cardiac Output; Cerebrovascular Circulation; Cocaine-Relate | 2005 |
Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Bone Morphogenetic Protein 2; Bone | 2005 |
An experimental animal model of fulminant hepatic failure in pigs.
Topics: Acidosis; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Blood Glucose; Blood Urea Nitrog | 2005 |
Concurrent monitoring of cerebral electrophysiology and metabolism after traumatic brain injury: an experimental and clinical study.
Topics: Action Potentials; Adult; Animals; Brain Diseases, Metabolic; Brain Injuries; Cerebral Cortex; Disea | 2005 |
[Polymeric nanoparticles with therapeutic gene for gene therapy: I. Preparation and in vivo gene transfer study].
Topics: Animals; Disease Models, Animal; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Lactic | 2005 |
Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb.
Topics: Actins; Animals; Biocompatible Materials; Capillaries; Disease Models, Animal; Drug Carriers; Hindli | 2005 |
Relationship between cerebral blood flow and oxygen metabolism, and extracellular glucose and lactate concentrations during middle cerebral artery occlusion and reperfusion: a microdialysis and positron emission tomography study in nonhuman primates.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Extracellular Space; Glucose; Infarcti | 2005 |
Pharmacological study of BRS, a new bicarbonated Ringer's solution, in haemorrhagic shock dogs.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Do | 2005 |
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury.
Topics: Age Factors; Aging; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Energy Metabol | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Upregulation of pentose phosphate pathway and preservation of tricarboxylic acid cycle flux after experimental brain injury.
Topics: Animals; Brain Injuries; Citric Acid Cycle; Disease Models, Animal; Glucose; Glutamic Acid; Glutamin | 2005 |
Short-chain fatty acid induces intestinal mucosal injury in newborn rats and down-regulates intestinal trefoil factor gene expression in vivo and in vitro.
Topics: Animals; Animals, Newborn; Butyrates; Colon; Disease Models, Animal; DNA; Dose-Response Relationship | 2005 |
Effects of olprinone on hepatosplanchnic circulation and mitochondrial oxidation in a porcine model of endotoxemia.
Topics: Animals; Disease Models, Animal; Electron Transport Complex IV; Endotoxemia; Endotoxins; Hemoglobins | 2005 |
Improved biocompatibility of bicarbonate/lactate-buffered PDF is not related to pH.
Topics: Animals; Bicarbonates; Buffers; Dialysis Solutions; Disease Models, Animal; Hydrogen-Ion Concentrati | 2006 |
The effect of ethanol on uncontrolled hemorrhage in a rodent model.
Topics: Alcoholic Intoxication; Animals; Blood Pressure; Disease Models, Animal; Ethanol; Heart Rate; Hemorr | 2005 |
[Experimental study on nerve conduit coated with chitin and filled with a guide-fiber].
Topics: Absorbable Implants; Animals; Biocompatible Materials; Chitin; Disease Models, Animal; Female; Guide | 2005 |
[Histological evaluation of poly (dextrogyr-levogyr) lactide acid-triiodothyronine in sciatic nerve defect of rat].
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Female; Lactic Acid; Male; Nerve Regenerat | 2005 |
Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Betamethasone; Choroid; Delayed-Action Prepa | 2006 |
The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels.
Topics: Animals; Anti-Bacterial Agents; Cardiac Output; Disease Models, Animal; Escherichia coli Infections; | 2006 |
Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Animals; Disease Models, Animal; Ephedrine; Female; H | 2006 |
Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructose-Bisphosphatase; Gluconeogenesis | 2006 |
The physiological changes of cumulative hemorrhagic shock in conscious rats.
Topics: Anesthesia; Animals; Blood Pressure; Consciousness; Cytokines; Disease Models, Animal; Heart Rate; I | 2006 |
Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study.
Topics: Acidosis; Animals; Disease Models, Animal; Endotoxemia; Escherichia coli Infections; Hemodynamics; H | 2006 |
24-hour pretreatment with delta opioid enhances survival from hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Ischemic Preconditioning; Lactic Acid; | 2006 |
Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal drug delivery system of all-trans retinoic acid.
Topics: Absorbable Implants; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Del | 2006 |
[Influence of glucose-insulin-potassium on the levels of inflammatory cytokines and prognosis of MODS in the scalded rats].
Topics: Animals; Blood Glucose; Burns; Cytokines; Disease Models, Animal; Glucose; Insulin; Lactic Acid; Mul | 2005 |
Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: comparison with control hydrophobic one.
Topics: Animals; Biocompatible Materials; Disease Models, Animal; Hydrogen-Ion Concentration; Lactic Acid; M | 2006 |
A novel paclitaxel-eluting porous carbon-carbon nanoparticle coated, nonpolymeric cobalt-chromium stent: evaluation in a porcine model.
Topics: Analysis of Variance; Animals; Carbon; Chromium; Coated Materials, Biocompatible; Cobalt; Coronary A | 2006 |
Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Hydrogen-Ion Concentration; Lactic Acid; Ma | 2006 |
Therapeutic and toxicological evaluations of cyclosporine a microspheres as a treatment vehicle for uveitis in rabbits.
Topics: Animals; Aqueous Humor; Biocompatible Materials; Cyclosporine; Disease Models, Animal; Drug Carriers | 2006 |
Polytetrafluoroethylene/polylactide-co-glycolide laminate containing dexamethasone allows delayed adjustable strabismus surgery in a rabbit model.
Topics: Animals; Anti-Inflammatory Agents; Delayed-Action Preparations; Dexamethasone; Disease Models, Anima | 2006 |
Early difference in apoptosis of intestinal mucosa of rats with severe uncontrolled hemorrhagic shock after three fluid resuscitation methods.
Topics: Animals; Apoptosis; Blood Pressure; Disease Models, Animal; Flow Cytometry; Fluid Therapy; In Situ N | 2006 |
Resuscitation of severe but brief haemorrhagic shock with PFC in rabbits restores skeletal muscle oxygen delivery and does not alter skeletal muscle metabolism.
Topics: Animals; Blood Pressure; Blood Substitutes; Disease Models, Animal; Fluorocarbons; Hyperoxia; Lactic | 2006 |
Changes in diffusion parameters, energy-related metabolites and glutamate in the rat cortex after transient hypoxia/ischemia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Energy Metabolism; Extracellular Space; Glucose; G | 2006 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
Fructose-1,6-bisphosphate supports cerebral energy metabolism in pigs after ischemic brain injury caused by experimental particle embolization.
Topics: Animals; Brain; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal | 2006 |
Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care.
Topics: Animals; Blood Pressure; Blood Substitutes; Body Temperature; Cattle; Disease Models, Animal; Female | 2006 |
Vitamin A palmitate and aciclovir biodegradable microspheres for intraocular sustained release.
Topics: Acyclovir; Administration, Topical; Animals; Antiviral Agents; Biocompatible Materials; Calorimetry, | 2006 |
Brain metabolism and extracellular space diffusion parameters during and after transient global hypoxia in the rat cortex.
Topics: Animals; Cerebral Cortex; Diffusion; Disease Models, Animal; Down-Regulation; Energy Metabolism; Ext | 2007 |
Development and mechanisms of fetal hypoxia in severe fetal growth restriction.
Topics: Animals; Blood Glucose; Body Temperature; Disease Models, Animal; Female; Fetal Blood; Fetal Growth | 2007 |
Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiac Output; Disease Models, A | 2006 |
Synovial fluid metabolites in osteonecrosis.
Topics: Animals; Biomarkers; Bone Transplantation; Combined Modality Therapy; Disease Models, Animal; Dogs; | 2007 |
Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.
Topics: Adenosine Triphosphate; Animals; Brain; Creatine; Disease Models, Animal; Female; Fetal Hypoxia; Glu | 2006 |
Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction.
Topics: Acidosis, Lactic; Administration, Inhalation; Animals; Blood Pressure; Carbon Dioxide; Cardiovascula | 2007 |
Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Aspartate Aminotransferases; Cytochrom | 2007 |
Negative mesenteric effects of lung recruitment maneuvers in oleic acid lung injury are transient and short lasting.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Cardiac O | 2007 |
Evaluation of particulate systems supporting tumor cell fractions in a preventive vaccination against intracranial rat glioma.
Topics: Animals; Antigens, Neoplasm; Biocompatible Materials; Brain Neoplasms; Cancer Vaccines; Cell Fractio | 2006 |
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Brain; Cerebrovascular Circulation; Dis | 2007 |
Selected biochemical variables in a model of neonatal anoxia in rats.
Topics: Acetylglucosaminidase; Animals; Animals, Newborn; Biomarkers; Brain Chemistry; Disease Models, Anima | 2006 |
Lactate extraction and myocardial damage after countershock at different energy levels.
Topics: Anesthetics, Inhalation; Animals; Cardiomyopathies; Differential Threshold; Disease Models, Animal; | 1988 |
Unveiling gender differences in demand ischemia: a study in a rat model of genetic hypertension.
Topics: Animals; Coronary Circulation; Diastole; Disease Models, Animal; Disease Susceptibility; Female; Hyp | 2007 |
Magnetic resonance lactate and lipid signals in rat brain after middle cerebral artery occlusion model.
Topics: Animals; Azo Compounds; Brain; Cerebral Infarction; Disease Models, Animal; Female; Infarction, Midd | 2007 |
Long-lasting bioresorbable poly(lactic acid) (PLA94) mesh: a new approach for soft tissue reinforcement based on an experimental pilot study.
Topics: Abdominal Wall; Absorbable Implants; Animals; Collagen; Disease Models, Animal; Female; Lactic Acid; | 2007 |
Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected mice.
Topics: Animals; Anti-Bacterial Agents; Brucella melitensis; Brucellosis; Disease Models, Animal; Drug Carri | 2007 |
Effects of sequential changes from conventional ventilation to high-frequency oscillatory ventilation at increasing mean airway pressures in an ovine model of combined lung and head injury.
Topics: Analysis of Variance; Animals; Blood Flow Velocity; Carbon Dioxide; Cerebral Infarction; Cerebrovasc | 2007 |
Repair of full-thickness cartilage defects with cells of different origin in a rabbit model.
Topics: Animals; Cartilage, Articular; Cell Transplantation; Cells, Cultured; Chondrocytes; Cord Blood Stem | 2007 |
Association of increased myocardial contractility and elevated end-diastolic wall tension with short-term myocardial ischemia: a pressure-volume analysis.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Gas Analysis; Blood Pressure; | 2007 |
Repair of osteochondral defects with a new porous synthetic polymer scaffold.
Topics: Absorbable Implants; Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Lactic Aci | 2007 |
Taurine as a marker for foetal wellbeing?
Topics: Amino Acids; Animals; Biomarkers; Disease Models, Animal; Female; Fetal Death; Fetal Development; Fe | 2007 |
Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle.
Topics: Animals; Cell Line; Cell Shape; Cell Survival; Disease Models, Animal; Glucose; Hydrogen-Ion Concent | 2007 |
Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone, administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs.
Topics: Analysis of Variance; Animals; Biomarkers; Blood Pressure; Calcium Channel Blockers; Cardiac Output; | 2007 |
Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Blood Glucose; Disease Models, Animal; Hypot | 2007 |
A protective allergy vaccine based on CpG- and protamine-containing PLGA microparticles.
Topics: Adjuvants, Immunologic; Allergens; Anaphylaxis; Animals; Bee Venoms; Chemistry, Pharmaceutical; Dese | 2007 |
Timing of return to normal activities after orbital floor fracture repair.
Topics: Animals; Compressive Strength; Disease Models, Animal; Female; Fracture Fixation; Fracture Healing; | 2007 |
Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage.
Topics: Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Isotonic Solutions; Lactic Acid; Male; | 2007 |
Repair of porcine articular cartilage defect with a biphasic osteochondral composite.
Topics: Animals; Biocompatible Materials; Calcification, Physiologic; Calcium Phosphates; Cartilage, Articul | 2007 |
Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status.
Topics: Animals; Basilar Artery; Biomarkers; Cisterna Magna; Disease Models, Animal; Lactic Acid; Male; Nerv | 2007 |
Neurochemical monitoring using intracerebral microdialysis during systemic haemorrhage.
Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Disease Models, Animal; Energy Metabol | 2007 |
Lactate and glycerol released to the intestinal lumen reflect mucosal injury and permeability changes caused by strangulation obstruction.
Topics: Animals; Cell Membrane Permeability; Disease Models, Animal; Glycerol; Intestinal Mucosa; Intestinal | 2007 |
Muscle fatigue increases the probability of developing hyperalgesia in mice.
Topics: Animals; Carbon Dioxide; Cumulative Trauma Disorders; Disease Models, Animal; Dose-Response Relation | 2007 |
Evaluating tissue perfusion using labelled water indicator microdialysis in a rat model of haemorrhagic shock.
Topics: Animals; Blood Pressure; Disease Models, Animal; Lactic Acid; Liver; Male; Microdialysis; Muscle, Sk | 2007 |
The novel hemoglobin-based oxygen carrier HRC 101 improves survival in murine sickle cell disease.
Topics: Albumins; Anemia, Sickle Cell; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blood Substitut | 2007 |
ICVTS on-line discussion A. Further testing is warranted to detect more subtle degrees...
Topics: Anaerobic Threshold; Animals; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Artery Diseas | 2007 |
Effect of T. chebula on mitochondrial alterations in experimental myocardial injury.
Topics: Animals; Cytochromes; Disease Models, Animal; Lactic Acid; Male; Microscopy, Electron, Transmission; | 2007 |
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model.
Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidne | 2007 |
Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
Topics: Ammonia; Animals; Brain Chemistry; Disease Models, Animal; Extracellular Space; Female; Glutamic Aci | 2007 |
Rescue of SCID murine ischemic hindlimbs with pH-modified rhbFGF/poly(DL-lactic-co-glycolic acid) implants.
Topics: Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Drug Carriers; Fibroblast Growth Fact | 2007 |
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid | 2007 |
Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high-resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis.
Topics: Animals; Choline; Chronic Disease; Diagnosis, Differential; Disease Models, Animal; Lactic Acid; Lip | 2007 |
Prenatal cord clamping in newborn Macaca nemestrina: a model of perinatal asphyxia.
Topics: Animals; Animals, Newborn; Asphyxia; Brain; Disease Models, Animal; Electroencephalography; Erythrop | 2007 |
In vitro and in vivo demonstration of risperidone implants in mice.
Topics: Animals; Behavior, Animal; Biocompatible Materials; Disease Models, Animal; Drug Delivery Systems; D | 2008 |
The effect of simvastatin on remodelling of the alveolar bone following tooth extraction.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Biocompatible Materials; Bone Density; Bone Remodelin | 2008 |
Caecal ligation and puncture in the rat mimics the pathophysiological changes in human sepsis and causes multi-organ dysfunction.
Topics: Animals; Blood Glucose; Body Temperature; Body Weight; Cecum; Disease Models, Animal; Eating; Humans | 2007 |
[Research about schwann cells and PLGA implanted to rat transected spinal cord].
Topics: Animals; Cells, Cultured; Disease Models, Animal; Evoked Potentials, Motor; Female; Immunohistochemi | 2007 |
In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Glioblastoma; Humans; Lactic A | 2008 |
The control of hepatic glycogen metabolism in an in vitro model of sepsis.
Topics: Adenylate Kinase; Animals; Cytokines; Disease Models, Animal; Glucose; Glucose-6-Phosphate; Glycogen | 2008 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Nanoparticle-based oral drug delivery system for an injectable antibiotic - streptomycin. Evaluation in a murine tuberculosis model.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Delivery Systems; | 2007 |
Resuscitation from hemorrhagic shock comparing standard hemoglobin-based oxygen carrier (HBOC)-201 versus 7.5% hypertonic HBOC-201.
Topics: Animals; Biomarkers; Blood Substitutes; Disease Models, Animal; Dose-Response Relationship, Drug; He | 2007 |
Inhibitory efficacy of intravitreal dexamethasone acetate-loaded PLGA nanoparticles on choroidal neovascularization in a laser-induced rat model.
Topics: Animals; Choroidal Neovascularization; Chromatography, High Pressure Liquid; Delayed-Action Preparat | 2007 |
Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance.
Topics: Acidosis; Acute Disease; Animals; Blood Pressure; Cardiac Output; Central Venous Pressure; Chronic D | 2008 |
[Study on repair of critical calvarial defects with nano-hydroxyapatite/collagen/polylactic acid material compounded recombinant human bone morphogenetic protein 2 in rabbits].
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantati | 2007 |
Experimental study of controlled fluid resuscitation in the treatment of severe and uncontrolled hemorrhagic shock.
Topics: Animals; Apoptosis; Blood Pressure; Disease Models, Animal; Fluid Therapy; Hematocrit; Hemoglobins; | 2007 |
Effects of the TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats.
Topics: Animals; Cytokines; Disease Models, Animal; Lactic Acid; Lipid Peroxidation; Male; Membrane Glycopro | 2008 |
1H NMR-based metabolomic analysis of liver, serum, and brain following ethanol administration in rats.
Topics: Alanine; Alcoholic Intoxication; Animals; Antioxidants; Brain; Butylated Hydroxytoluene; Central Ner | 2008 |
In vitro degradation and in vivo biocompatibility of poly(lactic acid) mesh for soft tissue reinforcement in vaginal surgery.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Disease Models, Animal; Female; Herniorrhaphy | 2008 |
Drainage and antireflux characteristics of a biodegradable self-reinforced, self-expanding X-ray-positive poly-L,D-lactide spiral partial ureteral stent: an experimental study.
Topics: Absorbable Implants; Animals; Disease Models, Animal; Dogs; Lactic Acid; Membranes, Artificial; Poly | 2007 |
Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism.
Topics: Animals; Disease Models, Animal; Heart Transplantation; Hypothermia, Induced; Lactic Acid; Magnetic | 2008 |
Oral nanoparticulate atorvastatin calcium is more efficient and safe in comparison to Lipicure in treating hyperlipidemia.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Atorvastatin; Blood Glucose; Cholesterol; D | 2008 |
Administration of milrinone before ischemia, in the presence of beta-blockade, to treat metabolic impairment and myocardial stunning in pigs.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Coronary S | 2008 |
Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Glucose; Body Temperature; Carbon Dioxide; | 2008 |
Mouse model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres.
Topics: Animals; Bleomycin; Chemokine CCL2; Collagen; Collagen Type I; Collagen Type I, alpha 1 Chain; Conne | 2008 |
Preliminary study of the effect of FK506 nanospheric-suspension eye drops on rejection of penetrating keratoplasty.
Topics: Animals; Cornea; Dexamethasone; Disease Models, Animal; Female; Graft Rejection; Graft Survival; Imm | 2008 |
[Hemorrheological changes in irreversible hemorrhagic shock].
Topics: Animals; Blood Viscosity; Disease Models, Animal; Erythrocyte Aggregation; Erythrocyte Deformability | 2008 |
Bone generation in the reconstruction of a critical size calvarial defect in an experimental model.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Diseases; Bone Matrix; Bone Morphogeneti | 2008 |
Neuroprotective effect of deep hypothermic circulatory arrest with low priming volume: study in a rabbit model.
Topics: Animals; Blood Volume; Brain Ischemia; Chromatography, High Pressure Liquid; Circulatory Arrest, Dee | 2008 |
Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Calcium; Cardiotonic Agents; Disease Models, Animal; Fem | 2008 |
The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects.
Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Bone Marrow Cells; Cartilage, Articular; | 2009 |
Polymer-hydroxyapatite composite versus polymer interference screws in anterior cruciate ligament reconstruction in a large animal model.
Topics: Animals; Anterior Cruciate Ligament; Biocompatible Materials; Bone Screws; Disease Models, Animal; D | 2008 |
Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Stenosis; Disease Models, Animal; Do | 2008 |
ECG and heart rate variability changes in preterm and near-term fetal lamb following LPS exposure.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Disease Models, Animal; Electrocardiography; Female; Fet | 2008 |
Effect of different biomedical membranes on alkali-burned cornea.
Topics: Animals; Burns, Chemical; Chitosan; Collagen; Corneal Diseases; Disease Models, Animal; Epithelium, | 2008 |
Decreases in myocardial glucose and increases in pyruvate but not ischaemia are observed during porcine endotoxaemia.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Endotoxemia; Glucose; Lactic Acid; M | 2008 |
Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Fluid Therapy; Hemodynamics; Hydrazones; Lactic | 2008 |
Reproducibility of an animal model simulating complex combat-related injury in a multiple-institution format.
Topics: Acidosis; Animals; Blood Gas Analysis; Disease Models, Animal; Femoral Fractures; Hematocrit; Hemody | 2009 |
[Effects of methylene blue on refractory hemorrhagic shock].
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Interleukin-6; Interleukin-8; Lactic Acid; | 2008 |
Protective effects and role of endotoxin in experimental septicemia.
Topics: Animals; Bacteriological Techniques; Blood Glucose; Cecum; Disease Models, Animal; Endotoxins; Esche | 1984 |
Metabolism and transport of L-glutamine and L-alanine by renal tubules of chickens.
Topics: Acidosis, Respiratory; Alanine; Alkalosis, Respiratory; Animals; Biological Transport; Carbon Dioxid | 1983 |
Metabolic studies of HgCl2-induced acute renal failure in the rat.
Topics: Acute Kidney Injury; Adenine Nucleotides; Animals; Creatinine; Disease Models, Animal; Dithiothreito | 1981 |
A pharmacologically pertinent animal model of mania.
Topics: Affective Disorders, Psychotic; Animals; Bipolar Disorder; Disease Models, Animal; Electroshock; Hum | 1981 |
[Effect of adenosine triphosphate-magnesium chloride administration for post-ischemic acute renal failure (I)].
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Disease Models, Animal; Electrolytes; Energy M | 1983 |
Metabolic studies of postischemic acute renal failure in the rat.
Topics: Acute Kidney Injury; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine | 1984 |
Transmural changes in porcine and canine hearts after circumflex artery occlusion.
Topics: Adenosine Triphosphate; Animals; Arterial Occlusive Diseases; Coronary Circulation; Coronary Vessels | 1984 |
Effect of fluoride on growth and acid production by Streptococcus mutans in dental plaque.
Topics: Acetates; Acetic Acid; Animals; Dental Plaque; Disease Models, Animal; Fluorides; Formates; Germ-Fre | 1984 |
High energy phosphate depletion in a model of defective muscle glycolysis.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Fructosediphosphates; Glycogen; Glycolysis; | 1983 |
Metabolic studies of glycerol-induced acute renal failure in the rat.
Topics: Acute Kidney Injury; Adenine Nucleotides; Animals; Creatinine; Dihydroxyacetone; Disease Models, Ani | 1981 |
Effects of spiraprilat, an angiotensin-converting enzyme inhibitor, on anesthetized dogs in a new model of acute left ventricular failure.
Topics: Adenosine Triphosphate; Anesthesia; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressur | 1993 |
L-arginine improves resting cardiac transmembrane potential after burn injury.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Burns; Disease Models, Animal; Heart; L | 1994 |
Mechanisms of myocardial hypercarbic acidosis during cardiac arrest.
Topics: Acidosis; Animals; Blood Flow Velocity; Carbon Dioxide; Coronary Circulation; Disease Models, Animal | 1995 |
Dynamics of myocardial metabolism in the preconditioned porcine heart studied using continuous microdialysis.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Chromatography, High Pressure Liquid; Disease Models, | 1995 |
Concentrations of catecholamines in transplanted hearts after extracorporeal perfusion and cold storage.
Topics: Animals; Cold Temperature; Disease Models, Animal; Heart Transplantation; Lactates; Lactic Acid; Mal | 1995 |
Isochloremic hypertonic solutions for severe hemorrhage.
Topics: Acetates; Acetic Acid; Animals; Blood Gas Analysis; Blood Proteins; Blood Volume; Chlorides; Dextran | 1993 |
Effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein (rBPI23) on cerebrospinal fluid inflammation induced by endotoxin.
Topics: Animals; Antimicrobial Cationic Peptides; Blood Proteins; Cerebrospinal Fluid; Disease Models, Anima | 1995 |
Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia.
Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Gerbillinae; Hippocampus; Lact | 1994 |
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; C | 1994 |
Detection of liver ischemia using microdialysis during experimental peritonitis in pigs.
Topics: Acidosis, Lactic; Animals; Disease Models, Animal; Extracellular Space; Female; Hypoxanthine; Hypoxa | 1994 |
Glucose, lactate, insulin, and somatostatin responses to endotoxin in developing rats.
Topics: Age Factors; Animals; Bacterial Toxins; Blood Glucose; Disease Models, Animal; Endotoxins; Female; H | 1994 |
Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in rats.
Topics: Abdomen; Animals; Cecal Diseases; Disease Models, Animal; Endothelins; Endotoxins; Interleukin-6; In | 1995 |
Effects of diazoxide on norepinephrine-induced vasocontraction and ischemic myocardium in rats.
Topics: Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Diazoxide; Disease Models, Animal; Dose-Res | 1994 |
Degradation kinetics of biodegradable DL-polylactic acid biodegradable implants depending on the site of implantation.
Topics: Animals; Biodegradation, Environmental; Bone Plates; Bone Screws; Disease Models, Animal; Elasticity | 1994 |
Protection from reperfusion-induced arrhythmias by polyethylene glycol 600.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Disease Mod | 1993 |
Effect of poly DL-lactide--co-glycolide implants and xenogeneic bone matrix-derived growth factors on calvarial bone repair in the rabbit.
Topics: Animals; Biocompatible Materials; Bone and Bones; Bone Matrix; Bone Morphogenetic Proteins; Bone Reg | 1994 |
Role of aspirin in modulating myocardial ischemic reperfusion injury.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Aspirin; Blood Pressure; Creatinine; Disease | 1994 |
Evaluation of human bone morphogenetic protein 2 in a canine spinal fusion model.
Topics: Animals; Biocompatible Materials; Bone Morphogenetic Proteins; Disease Models, Animal; Dogs; Growth | 1994 |
Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits.
Topics: Analysis of Variance; Animals; Brain Ischemia; Cardiopulmonary Bypass; Disease Models, Animal; Femal | 1994 |
Regional levels of lactate and norepinephrine after experimental brain injury.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Freezing; | 1994 |
Changes in hemodynamic and metabolic parameters following induced brain death in the pig.
Topics: Animals; Atrial Natriuretic Factor; Brain; Brain Death; Disease Models, Animal; Hemodynamics; Lactat | 1994 |
The relationship of base deficit to lactate in porcine hemorrhagic shock and resuscitation.
Topics: Acidosis; Animals; Disease Models, Animal; Hemodynamics; Lactates; Lactic Acid; Oxygen; Oxygen Consu | 1994 |
Peritoneal fluid lactic acid and diagnostic dilemmas in acute abdominal disease.
Topics: Abdomen, Acute; Abscess; Animals; Ascitic Fluid; Diagnosis, Differential; Disease Models, Animal; Do | 1994 |
Establishing a resuscitation model in rabbits with closed-thoracic cardiopulmonary by-pass.
Topics: Animals; Cardiopulmonary Bypass; Disease Models, Animal; Electroencephalography; Female; Heart Arres | 1994 |
Diltiazem preserves hepatic gluconeogenesis following hemorrhagic shock.
Topics: Animals; Diltiazem; Disease Models, Animal; Gluconeogenesis; Glucose; Isotonic Solutions; Lactates; | 1993 |
Insulin is a superior antidote for cardiovascular toxicity induced by verapamil in the anesthetized canine.
Topics: Anesthesia; Animals; Antidotes; Blood Glucose; Cardiovascular Diseases; Disease Models, Animal; Dogs | 1993 |
Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Brain; Brain Edema; Carbon Dioxide; Co | 1994 |
Sustained delivery of retinoic acid from microspheres of biodegradable polymer in PVR.
Topics: Animals; Biocompatible Materials; Biodegradation, Environmental; Delayed-Action Preparations; Diseas | 1993 |
Acceleration-induced effects on baboon blood chemistry.
Topics: Acceleration; Animals; Blood Glucose; Brain; Carbon Dioxide; Creatine Kinase; Disease Models, Animal | 1993 |
Effects of sodium lactate infusion on cisternal lactate and carbon dioxide levels.
Topics: Animals; Carbon Dioxide; Cerebrospinal Fluid; Cisterna Magna; Disease Models, Animal; Haplorhini; Hu | 1993 |
Substrate-induced changes in the lipid content of ischemic and reperfused myocardium. Its relation to hemodynamic recovery.
Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycerol; Heart; Lactates; Lactic Acid; Male; | 1993 |
Progression of hearing loss in experimental pneumococcal meningitis: correlation with cerebrospinal fluid cytochemistry.
Topics: Animals; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Cochlea; Disease Models, Animal; Ear, In | 1993 |
The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.
Topics: Animals; Blood Viscosity; Cell Count; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Erythro | 1993 |
Potentiation of decreased pyruvate dehydrogenase activity by inflammatory stimuli in sepsis.
Topics: Animals; Bacteremia; Bacterial Infections; Catheters, Indwelling; Disease Models, Animal; Inflammati | 1993 |
Intramyocardial hypercarbic acidosis during cardiac arrest and resuscitation.
Topics: Acidosis, Respiratory; Animals; Carbon Dioxide; Disease Models, Animal; Heart Arrest; Hemodynamics; | 1993 |
High-impact poly(L/D-lactide) for fracture fixation: in vitro degradation and animal pilot study.
Topics: Animals; Biodegradation, Environmental; Bone Plates; Bone Screws; Caprolactam; Disease Models, Anima | 1995 |
A sustained release bacterial inoculum infusion model of intra-abdominal infection in conscious rats: bacteriology, metabolism, and histopathology.
Topics: Animals; Blood Glucose; Body Temperature; Body Weight; Disease Models, Animal; Humans; Lactic Acid; | 1996 |
Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep.
Topics: Animals; Asphyxia Neonatorum; Blood Gas Analysis; Blood Pressure; Carboxylic Acids; Disease Models, | 1996 |
Acid-base disturbances in the rabbit during experimental hepatic parasitosis.
Topics: Acid-Base Imbalance; Animals; Bicarbonates; Blood Gas Monitoring, Transcutaneous; Coccidiosis; Disea | 1996 |
Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats.
Topics: Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus; Diabetes Mellitus, Type 2; D | 1996 |
Gram-negative shock in rats depends on the presence of capsulated bacteria and is modified by laparotomy.
Topics: Animals; Antigens, Bacterial; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; | 1996 |
Low-dose inotropic stimulation during left ventricular ischaemia does not worsen post-ischaemic dysfunction.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dobutamine; Female; Heart Rate; Lactic Acid; My | 1996 |
The burst phenomenon, an animal model simulating the long-term tissue response on PLLA interlocking nails.
Topics: Animals; Bone and Bones; Bone Nails; Disease Models, Animal; Female; Femur; Fracture Fixation; Lacti | 1996 |
Temporal changes in proton MRS metabolites after kainic acid-induced seizures in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cell Count; Choline; Creatinine; Dipeptides; Disease Models, Animal; | 1997 |
Effects of copper, iron and fluoride co-crystallized with sugar on caries development and acid formation in deslivated rats.
Topics: Acetates; Acids; Animals; Butyrates; Cariogenic Agents; Cariostatic Agents; Colony Count, Microbial; | 1996 |
Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus.
Topics: Animals; Antigens, Viral; Biocompatible Materials; Biodegradation, Environmental; Cytomegalovirus; C | 1997 |
Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model.
Topics: Animals; Biocompatible Materials; Constriction, Pathologic; Coronary Disease; Coronary Vessels; Dexa | 1997 |
Ischemia/reperfusion injury in the rat colon.
Topics: 6-Ketoprostaglandin F1 alpha; Aerobiosis; Aminosalicylic Acids; Anaerobiosis; Animals; Antioxidants; | 1997 |
Renal circulation and cellular metabolism during left ventricular assisted circulation: comparison study of pulsatile and nonpulsatile assists.
Topics: Animals; beta 2-Microglobulin; Blood Pressure; Blood Urea Nitrogen; Creatinine; Disease Models, Anim | 1997 |
Trovafloxacin delays the antibiotic-induced inflammatory response in experimental pneumococcal meningitis.
Topics: Adult; Animals; Anti-Infective Agents; Ceftriaxone; Cephalosporins; Disease Models, Animal; Fluoroqu | 1997 |
Lack of any additional benefit in combining aspirin with iloprost in a canine model of myocardial reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Aspirin; Blood Pressure; Cyclooxygenase Inhib | 1997 |
Treatment of osteomyelitis with a biodegradable antibiotic implant.
Topics: Animals; Anti-Bacterial Agents; Biodegradation, Environmental; Disease Models, Animal; Drug Delivery | 1997 |
Direct measurement of energy metabolism in the isolated working rat heart.
Topics: Animals; Disease Models, Animal; Energy Metabolism; Glucose; Glycolysis; Heart; Lactic Acid; Myocard | 1997 |
In situ detection of myocardial infarction in pig by measurements of aspartate aminotransferase (ASAT) activity in the interstitial fluid.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Biomarkers; Chromatography, High Pressure Liquid; | 1997 |
Antibiotic-loaded plaster of Paris implants coated with poly lactide-co-glycolide as a controlled release delivery system for the treatment of bone infections.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Biodegradation, Environmental; Calcium Sulf | 1997 |
Inhibition of nitric oxide synthesis aggravates myocardial ischemia in hemorrhagic shock in constant pressure model.
Topics: Adenosine Triphosphate; Animals; Aorta; Catecholamines; Disease Models, Animal; Dogs; Enzyme Inhibit | 1998 |
Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models.
Topics: Abdomen; Animals; Cellulose, Oxidized; Disease Models, Animal; Female; Intestinal Diseases; Lactic A | 1998 |
Positive biochemical effects of a bioartificial liver support system (BALSS) in a porcine fulminant hepatic failure (FHF) model.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Animals; Bioreactors; Cell Adhesion; Cells, Cultured; | 1998 |
Lipid peroxidation products and antioxidant capacity in portal venous and systemic arterial plasma during gradual intestinal ischemia and reperfusion in pigs.
Topics: Animals; Antioxidants; Disease Models, Animal; Female; Hemodynamics; Hydrogen-Ion Concentration; Int | 1998 |
Treatment with growth hormone and insulin-like growth factor-1 in septicemia: effects on carbohydrate metabolism.
Topics: Alanine; Animals; Bacteremia; Blood Glucose; Calorimetry, Indirect; Carbohydrate Metabolism; Disease | 1998 |
Markers of cellular dysoxia during orthotopic liver transplantation in pigs.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Biomarkers; Carnitine; Cell Hypoxia; Cytosol; Disease | 1998 |
Effects of anti-C5a monoclonal antibodies on oxygen use in a porcine model of severe sepsis.
Topics: Animals; Antibodies, Monoclonal; Bacteremia; Blood Pressure; Complement C5a; Disease Models, Animal; | 1998 |
Defect of an early event of glucose metabolism in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a non-insulin-dependent diabetes mellitus (NIDDM) model.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose-6-Phosphate; Glycogen S | 1998 |
Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat.
Topics: Analysis of Variance; Animals; Biomarkers; Brain Injuries; Disease Models, Animal; Disease Progressi | 1998 |
Systemic and regional pCO2 gradients as markers of intestinal ischaemia.
Topics: Acidosis, Lactic; Acidosis, Respiratory; Animals; Biomarkers; Carbon Dioxide; Disease Models, Animal | 1998 |
Hypothermia increases the threshold for ischemic preconditioning.
Topics: Animals; Body Temperature; Coronary Circulation; Disease Models, Animal; Glycogen; Hypothermia, Indu | 1998 |
In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants.
Topics: Animals; Anti-Infective Agents; Biocompatible Materials; Capsules; Ciprofloxacin; Disease Models, An | 1998 |
Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model.
Topics: Angioplasty, Balloon; Animals; Arteries; Biocompatible Materials; Biodegradation, Environmental; Chr | 1998 |
Prevention of retrosternal adhesion formation in a rabbit model using bioresorbable films of polyethylene glycol and polylactic acid.
Topics: Animals; Disease Models, Animal; Female; Lactic Acid; Materials Testing; Membranes, Artificial; Peri | 1998 |
Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury.
Topics: Acetylcarnitine; Animals; Dichloroacetic Acid; Disease Models, Animal; Energy Metabolism; Fatty Acid | 1998 |
Liver as a focus of impaired oxygenation and cytokine production in a porcine model of endotoxicosis.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Escherichia coli Infections; Hemodynamics; Inte | 1998 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |
Utility of clinical parameters of tissue oxygenation in a quantitative model of irreversible hemorrhagic shock.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Lactic Acid; Male; Oxygen; Rats; Rats, Sprague- | 1998 |
In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus.
Topics: Acute Disease; Analysis of Variance; Animals; Brain; Brain Edema; Brain Ischemia; Chronic Disease; D | 1998 |
Chemo-embolization of experimental liver metastases. Part I: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy.
Topics: Animals; Biocompatible Materials; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; | 1998 |
Fixation of osteotomies using bioabsorbable screws in the canine femur.
Topics: Absorbable Implants; Animals; Biocompatible Materials; Bone Screws; Disease Models, Animal; Dogs; Fe | 1998 |
Degradation of and intraosseous reactions to biodegradable poly-L-lactide screws: a study in minipigs.
Topics: Absorbable Implants; Animals; Biodegradation, Environmental; Bone and Bones; Bone Screws; Delayed-Ac | 1998 |
Surgical procedure affects physiological parameters in rat myocardial ischemia: need for mechanical ventilation.
Topics: Animals; Arteries; Blood Pressure; Disease Models, Animal; Electrocardiography; Electrolytes; Female | 1999 |
Controlled resuscitation for uncontrolled hemorrhagic shock.
Topics: Animals; Aorta; Disease Models, Animal; Fluid Therapy; Hematocrit; Hydroxyethyl Starch Derivatives; | 1999 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |
Two-compartment model for determination of glycolytic rates of solid tumors by in vivo 13C NMR spectroscopy.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Female; Fibrosarcoma; Glucose; Glycolysis; Lactic | 1998 |
Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cardiomegaly; Carrier Proteins; Disease Models, Anima | 1999 |
Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals. Generalized spectral localization by imaging.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Disorders; Disease Models, Animal; Filtration; Gerbi | 1999 |
Effects of hypoxia-ischemia and inhibition of nitric oxide synthase on cerebral energy metabolism in newborn piglets.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Anima | 1999 |
Simulated airplane flight increases plasma lactate in fetal rabbits.
Topics: Acidosis, Lactic; Aerospace Medicine; Altitude; Animals; Disease Models, Animal; Female; Fetal Hypox | 1999 |
Quinupristin/dalfopristin attenuates the inflammatory response and reduces the concentration of neuron-specific enolase in the cerebrospinal fluid of rabbits with experimental Streptococcus pneumoniae meningitis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cerebrospinal Fluid Proteins; Disease Models, Animal; I | 1999 |
Chemotherapy of tuberculosis in mice using single implants of isoniazid and pyrazinamide.
Topics: Administration, Oral; Analysis of Variance; Animals; Antitubercular Agents; Biocompatible Materials; | 1999 |
Influence of rewarming conditions after hypothermia in gerbils with transient forebrain ischemia.
Topics: Animals; Cerebrovascular Circulation; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hot Temper | 1999 |
Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Cerebral Cortex; Coloring Agents; Disease Models | 1999 |
Use of a polyglycolide lactide cement plug restrictor in total hip arthroplasty.
Topics: Animals; Arthroplasty, Replacement, Hip; Biocompatible Materials; Bone Cements; Cadaver; Compressive | 1999 |
A mechanism for shock following stomach rupture in the newborn.
Topics: Animals; Animals, Newborn; Blood Glucose; Disease Models, Animal; Endotoxins; Lactic Acid; Rats; Rat | 1999 |
Transmyocardial laser revascularisation has no beneficial effect on high energy phosphates and lactate content during acute myocardial ischaemia in pigs.
Topics: Acute Disease; Animals; Biopsy; Chromatography, High Pressure Liquid; Coloring Agents; Disease Model | 1999 |
Transventricular non-transmural laser treatment of hypoperfused porcine myocardium acutely reduces left ventricular contractile function.
Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Gas Analysis; Coronary Circulation; Coronary Dise | 1999 |
Efficacy of subconjunctival cyclosporin-containing microspheres on keratoplasty rejection in the rabbit.
Topics: Animals; Aqueous Humor; Biocompatible Materials; Conjunctiva; Cornea; Corneal Transplantation; Cyclo | 1999 |
Reduction of meningeal macrophages does not decrease migration of granulocytes into the CSF and brain parenchyma in experimental pneumococcal meningitis.
Topics: Analgesics, Non-Narcotic; Animals; Carboxylic Ester Hydrolases; Cell Count; Cell Movement; Cerebrosp | 1999 |
Bioabsorbable suture anchor (co-polymer 85/15 D,L lactide/glycolide) implanted in bone: correlation of physical/mechanical properties, magnetic resonance imaging, and histological response.
Topics: Absorbable Implants; Animals; Biomechanical Phenomena; Bone and Bones; Disease Models, Animal; Dogs; | 1999 |
Differential alterations in systemic and regional oxygen delivery and consumption during the early and late stages of sepsis.
Topics: Animals; Cardiac Output; Cecum; Cell Hypoxia; Disease Models, Animal; Intestine, Small; Kidney; Lact | 1999 |
Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis.
Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Apatites; Bone Cements; Bone Marrow; Bone T | 1999 |
Modulation of systemic hemodynamics by exogenous L-arginine in normal and bacteremic sheep.
Topics: Acidosis; Animals; Arginine; Bacteremia; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; | 1999 |
Postictal in situ MRS brain lactate in the rat kindling model.
Topics: Animals; Aspartic Acid; Brain Mapping; Creatine; Disease Models, Animal; Electroencephalography; Epi | 1999 |
What governs skeletal muscle VO2max? New evidence.
Topics: Anaerobic Threshold; Analysis of Variance; Animals; Diffusion; Disease Models, Animal; Dogs; Exercis | 2000 |
Effects of RGP lens extended wear on glucose-lactate metabolism and stromal swelling in the rabbit cornea.
Topics: Adenosine Triphosphate; Animals; Aqueous Humor; Biomarkers; Contact Lenses, Extended-Wear; Corneal E | 2000 |
Norepinephrine vs nitric oxide synthase inhibition in endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Female; Hepatic Artery; Lactic Acid | 1999 |
Accuracy of mucosal pH and mucosal-arterial carbon dioxide tension for detecting mesenteric hypoperfusion in acute canine endotoxemia.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Disease Models, Animal; Dogs; Endotoxemia; Escherichia | 2000 |
Hepatic and splanchnic oxygen consumption during acute hypoxemic hypoxia in anesthetized pigs.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hemodynamics; Hypoxia; Lactic Acid; L | 2000 |
Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Cyclic GMP; Disease Models, Anim | 2000 |
Microdialysis of the spinal cord during thoracic aortic cross-clamping in a porcine model.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Glucose; Glutamic Acid; Lactic Acid; Microdialysis | 2000 |
Intestinal metabolism after ischemia-reperfusion.
Topics: Amino Acids; Analysis of Variance; Animals; Disease Models, Animal; Glucose; Intestine, Small; Ische | 2000 |
Use of internal bioabsorbable PLGA "finger-type" stents in a rabbit tracheal reconstruction model.
Topics: Animals; Biocompatible Materials; Biomechanical Phenomena; Disease Models, Animal; Fascia; Lactic Ac | 2000 |
Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hosts.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cattle; Delayed-Action Preparations; Disease Models, An | 2000 |
Energy metabolism in graded perinatal asphyxia of the rat.
Topics: Adenine Nucleotides; Animals; Animals, Newborn; Asphyxia; Blood Gas Analysis; Brain; Chromatography, | 2000 |
Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion.
Topics: Animals; Carbon Dioxide; Cardiotonic Agents; Combined Modality Therapy; Disease Models, Animal; Dobu | 2000 |
Hepatic O2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: effects of iloprost.
Topics: Animals; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Ener | 2000 |
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease | 2001 |
In vitro inhibition of enamel demineralization by a polymerizable amphiphilic film.
Topics: Acrylates; Animals; Cariostatic Agents; Cattle; Dental Enamel; Dimethylpolysiloxanes; Disease Models | 2000 |
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Ani | 2000 |
The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage.
Topics: Animals; Axons; Blood Pressure; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cardiac Outpu | 2001 |
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
Topics: Animals; Basilar Artery; Caspase Inhibitors; Caspases; Cerebrospinal Fluid; Disease Models, Animal; | 2001 |
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock.
Topics: Animals; Blood Gas Analysis; Canavanine; Disease Models, Animal; Dogs; Endothelin-1; Enzyme Inhibito | 2001 |
Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia.
Topics: Acidosis, Lactic; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dogs; D | 2001 |
Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables.
Topics: Animals; Antihypertensive Agents; Blood Gas Analysis; Cats; Constriction, Pathologic; Disease Models | 2001 |
Ocular blood flow and retinal metabolism in abyssinian cats with hereditary retinal degeneration.
Topics: Animals; Blood Flow Velocity; Blood Glucose; Cardiovascular Agents; Cats; Choroid; Disease Models, A | 2001 |
Carboxyhemoglobin and lactate levels do not correlate in critically ill patients.
Topics: Animals; Biomarkers; Blood Gas Analysis; Carboxyhemoglobin; Critical Illness; Disease Models, Animal | 1999 |
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Dialysis Solutions; Disease Models, Animal | 2001 |
Effects of nicotinamide, an inhibitor of PARS activity, on gut and liver O2 exchange and energy metabolism during hyperdynamic porcine endotoxemia.
Topics: Animals; Blood Gas Analysis; Blood Pressure; Cardiac Output; Disease Models, Animal; Drug Evaluation | 2001 |
TNF-alpha increases sensitivity to LPS in chronically catheterized rats.
Topics: Animals; Catheterization; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Infus | 2001 |
Further studies on the effects of topical lactate on amino acid efflux from the ischemic rat cortex.
Topics: Administration, Topical; Amino Acids; Animals; Brain Ischemia; Cardiovascular Physiological Phenomen | 2001 |
17beta-Estradiol reduces cortical lesion size in the glutamate excitotoxicity model by enhancing extracellular lactate: a new neuroprotective pathway.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Estradiol; Ex | 2001 |
Chemotherapy of Mycobacterium tuberculosis infections in mice with a combination of isoniazid and rifampicin entrapped in Poly (DL-lactide-co-glycolide) microparticles.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Capsules; Disease Models, Animal; Drug | 2001 |
Increased ileal-mucosal-arterial PCO2 gap is associated with impaired villus microcirculation in endotoxic pigs.
Topics: Animals; Blood Gas Analysis; Carbon Dioxide; Disease Models, Animal; Endotoxemia; Escherichia coli I | 2001 |
Metabolic and hemodynamic effects of CO2 pneumoperitoneum in a controlled hemorrhage model.
Topics: Analysis of Variance; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Hemodynamics; | 2001 |
Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits.
Topics: 1-Deoxynojirimycin; Animals; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors; G | 2001 |
Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiopulmonary Resuscitation; Disease Models, Anim | 2001 |
7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain Diseases; Cerebral Cortex; Cerebrospinal Fluid; Dise | 2001 |
A pig hemorrhagic shock model: oxygen debt and metabolic acidemia as indicators of severity.
Topics: Animals; Disease Models, Animal; Female; Lactic Acid; Oxygen; Predictive Value of Tests; Probability | 2001 |
Histoprotective effect of antihypoxant olifen during experimental acute pancreatitis.
Topics: Amylases; Animals; Antioxidants; Cats; Disease Models, Animal; Lactic Acid; Oxidative Stress; Pancre | 2001 |
Marked anemic hypoxia deteriorates cerebral hemodynamics and brain metabolism during massive intracerebral hemorrhage.
Topics: Anemia; Animals; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Mo | 2001 |
Evaluation of poly-L-lactic acid and polyglycolic acid resorbable stents for repair of tracheomalacia in a porcine model.
Topics: Absorbable Implants; Animals; Cartilage Diseases; Disease Models, Animal; Lactic Acid; Polyesters; P | 2001 |
Sodium pyruvate is better than sodium chloride as a resuscitation solution in a rodent model of profound hemorrhagic shock.
Topics: Animals; Blood Glucose; Cardiotonic Agents; Disease Models, Animal; Lactic Acid; Male; Pyruvic Acid; | 2001 |
Effects of epinephrine in a pig model of hypothermic cardiac arrest and closed-chest cardiopulmonary resuscitation combined with active rewarming.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Body Temperature; Cardiopulmonary Resuscitation; | 2001 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |
Investigation of skeletal muscle denervation and reinnervation using magnetic resonance spectroscopy.
Topics: Action Potentials; Analysis of Variance; Animals; Choline; Disease Models, Animal; Electromyography; | 2001 |
Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs.
Topics: Acidosis; Animals; Animals, Newborn; Asphyxia Neonatorum; Blood Pressure; Cerebral Cortex; Cerebrova | 2001 |
N(omega) -nitro-L-arginine methyl ester (L-NAME) attenuates the acute inflammatory responses and brain injury during the early phase of experimental Escherichia coli meningitis in the newborn piglet.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain Chemistry; Disease Models, Animal; Enzyme Inhibitors | 2001 |
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction.
Topics: 1-Deoxynojirimycin; Adenosine Triphosphate; Animals; Blood Flow Velocity; Disease Models, Animal; En | 2000 |
Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats.
Topics: Animals; Biomarkers; Burns; Disease Models, Animal; Intestines; Ischemia; Kinetics; Lactic Acid; Lip | 2001 |
Cardiac energetics in congestive heart failure.
Topics: Animals; Carbohydrate Metabolism; Disease Models, Animal; Energy Metabolism; Glycolysis; Heart Failu | 2002 |
Metabolism of D-[3-3H]glucose, D-[5-3H]glucose, D-[U-14C]glucose, D-[1-14C]glucose and D-[6-14C]glucose in pancreatic islets in an animal model of type-2 diabetes.
Topics: Animals; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glycolysi | 2002 |
Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms.
Topics: Absorbable Implants; Aneurysm; Angiography; Animals; Biocompatible Materials; Blood Vessel Prosthesi | 2002 |
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Biocompatible Materials; Catt | 2002 |
Lactate accumulation rather than ATP depletion predicts ischemic myocardial necrosis: implications for the development of lethal myocardial injury.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Lactic Acid; Myocardial Ischemia; Myocardiu | 2002 |
In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices.
Topics: Animals; Anti-Inflammatory Agents; Biosensing Techniques; Delayed-Action Preparations; Dexamethasone | 2002 |
Effects of locally-delivered human macrophage products and estrogen on murine inflammatory bone resorption.
Topics: Analysis of Variance; Animals; Bone Resorption; Cell Count; Disease Models, Animal; Down-Regulation; | 2002 |
Monitoring of porcine myocardial ischemia and reperfusion by intravasal microdialysis.
Topics: Animals; Biomarkers; Blood Glucose; Disease Models, Animal; Female; Glutamic Acid; Glycerol; Hemodyn | 2002 |
Increasing P(50) does not improve DO(2CRIT) or systemic VO(2) in severe anemia.
Topics: Acid-Base Equilibrium; Anemia; Aniline Compounds; Animals; Antisickling Agents; Arteries; Blood Volu | 2002 |
Mechanical properties of the femur after injection of calcium phosphate cement containing arbekacin sulfate and polylactic acid in a rat model of experimental osteoporosis.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Biocompatible Materials; Bone Cements; Calcium Phos | 2002 |
Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Carrier Proteins; Citrate (si)-Synthase; Diabetes M | 2002 |
Chronic hypoxia: a model for cyanotic congenital heart defects.
Topics: Adenosine Triphosphate; Animals; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Disease Models, | 2002 |
Evaluation of a new ultrasound contrast agent (AI-700) using two-dimensional and three-dimensional imaging during acute ischemia.
Topics: Animals; Contrast Media; Disease Models, Animal; Dogs; Echocardiography, Three-Dimensional; Fluoroca | 2002 |
Neuroscientists begin to piece together more parts of Huntington's disease puzzle.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Chemistry; Dise | 1992 |
A narrow range, medium molecular weight pentastarch reduces structural organ damage in a hyperdynamic porcine model of sepsis.
Topics: Biopsy; Blood Flow Velocity; Blood Gas Analysis; Disease Models, Animal; Drug Evaluation, Preclinica | 1992 |
The effect of hyperglycemia on acid-base and sympathoadrenal responses in the hypoxemic fetal monkey.
Topics: Acid-Base Equilibrium; Adrenal Glands; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Catec | 1992 |
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Anima | 1992 |
Glucose-associated alterations in ischemic brain metabolism of neonatal piglets.
Topics: Adenosine Triphosphate; Age Factors; Animals; Animals, Newborn; Blood Glucose; Blood-Brain Barrier; | 1992 |
Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment.
Topics: Acidosis; Animals; Disease Models, Animal; Dogs; Hemodynamics; Ibuprofen; Lactates; Lactic Acid; Oxy | 1992 |
Increased plasma concentrations of hyaluronan after major thermal injury in the rat.
Topics: Animals; Burns; Disease Models, Animal; Female; Hyaluronic Acid; Lactates; Lactic Acid; Molecular We | 1992 |
The isolated perfused rat liver as an experimental model.
Topics: Albumins; Amino Acids; Ammonia; Animals; Biological Availability; Disease Models, Animal; Evaluation | 1992 |
[Improving effect of the synthetic protease inhibitor E-3123 on experimental DIC in dogs].
Topics: Animals; Blood Coagulation Tests; Disease Models, Animal; Disseminated Intravascular Coagulation; Do | 1992 |
[Evaluation of the effectiveness of infusion solutions based on electron-microscopic studies].
Topics: Animals; Dextrans; Disease Models, Animal; Drug Evaluation, Preclinical; Lactates; Lactic Acid; Live | 1990 |
A new model of focal brain ischemia based on the intracerebral injection of endothelin-1.
Topics: Animals; Brain Chemistry; Brain Ischemia; Corpus Striatum; Densitometry; Disease Models, Animal; Dop | 1991 |
Experimental sinusitis in rabbits induced by aerobic and anaerobic bacteria: models for research in sinusitis.
Topics: Animals; Bacteroides fragilis; Bacteroides Infections; Blood Flow Velocity; Disease Models, Animal; | 1991 |
Hepatic vascular exclusion as a model for complete and stable hepatic ischemia in dogs.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Indocyanine Green; Ischemia; Ketone Bodies; L | 1991 |
Effects of pentoxifylline on hemodynamics, oxygen transport, and tissue metabolism in experimental, severe hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Hemodynami | 1991 |
Studies of myocardial protection in the immature heart. III. Models of ischemic and hypoxic/ischemic injury in the immature puppy heart.
Topics: Adenosine Triphosphate; Amino Acids, Dicarboxylic; Animals; Carboxylic Acids; Coronary Circulation; | 1991 |
[Comparative evaluation of the effects of crystalloid solutions containing sodium lactate and sodium succinate on the hemodynamic indicators in different types of hemorrhage].
Topics: Animals; Crystalloid Solutions; Disease Models, Animal; Female; Hemodynamics; Hemorrhage; Isotonic S | 1991 |
In search of missing links in otology. II. Development of an implantable middle ear drug delivery system: initial studies of sustained ampicillin release for the treatment of otitis media.
Topics: Administration, Topical; Ampicillin; Animals; Biodegradation, Environmental; Chinchilla; Delayed-Act | 1991 |
Use of animals in research on panic disorder.
Topics: Animal Testing Alternatives; Animal Welfare; Animals; Anxiety Disorders; Disease Models, Animal; Hap | 1990 |
Buffer agents do not reverse intramyocardial acidosis during cardiac resuscitation.
Topics: Acidosis; Animals; Bicarbonates; Blood; Buffers; Carbon Dioxide; Carbonates; Disease Models, Animal; | 1990 |
[Proton and phosphorus-31 nuclear magnetic resonance spectroscopy in experimental cerebral infarction in rats].
Topics: Animals; Brain; Cerebral Infarction; Disease Models, Animal; Energy Metabolism; Lactates; Lactic Aci | 1990 |
Glucoregulatory, hormonal, and metabolic responses to endotoxicosis or cecal ligation and puncture sepsis in the rat: a direct comparison.
Topics: Animals; Blood Glucose; Cecum; Disease Models, Animal; Glucagon; Insulin; Kinetics; Lactates; Lactic | 1990 |
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. II. Analysis of brain metabolism using 31P- and 1H-nuclear magnetic resonance spectroscopy].
Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Energy Metabolism; Lactates; Lactic Acid; Magne | 1990 |
Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels.
Topics: Animals; Azo Compounds; Azoxymethane; Calcium; Calcium, Dietary; Colonic Neoplasms; Dietary Fats; Di | 1990 |
Lipidperoxidation in a canine model of hypovolemic-traumatic shock.
Topics: Aldehydes; Animals; Disease Models, Animal; Dogs; Free Radicals; Hydrogen Peroxide; Hypoxanthine; Hy | 1989 |
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexo | 1986 |
[Effects of S-adenosyl-L-methionine on experimental cerebral ischemia].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Cyclic AMP; Disea | 1985 |
Late aluminum therapy reduces the cellular activities of simple silicosis in the sheep model.
Topics: Aluminum; Animals; Collagen; Disease Models, Animal; Lactates; Lactic Acid; Lung; Sheep; Silicon Dio | 1987 |
Hyperlactataemia, hyperkalemia and heart block in acute iron overload: the fatal role of the hepatic iron-incorporation rate in rats on ferric citrate infusions.
Topics: Animals; Disease Models, Animal; Electrocardiography; Ferric Compounds; Heart Block; Heart Conductio | 1988 |
Effect of recirculation on the recovery of cerebral metabolism after experimental cerebral ischemia in male and female spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cerebrov | 1988 |
Thick brain slices model the ischemic penumbra.
Topics: Animals; Body Water; Brain; Brain Ischemia; Deoxyglucose; Disease Models, Animal; Histological Techn | 1988 |
A nonhuman primate model of panic disorder.
Topics: Agoraphobia; Animals; Arousal; Disease Models, Animal; Fear; Female; Lactates; Lactic Acid; Macaca; | 1988 |
Renal, cerebral, and pulmonary effects of hypertonic resuscitation in a porcine model of hemorrhagic shock.
Topics: Animals; Blood Pressure; Brain; Cardiac Output; Creatinine; Disease Models, Animal; Female; Hemodyna | 1988 |
Consequences of perturbations of fetal fuels in ovine pregnancy.
Topics: Animals; Blood Glucose; Disease Models, Animal; Female; Fetal Blood; Fetal Hypoxia; Fetus; Glucose; | 1985 |
[Hyperdynamic state induced by continuous infusion of E. coli endotoxin in dogs].
Topics: Amino Acids; Animals; Blood Glucose; Catecholamines; Disease Models, Animal; Dogs; Endotoxins; Esche | 1985 |