lactic acid and Disease Exacerbation studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"Plasma albuterol was significantly correlated with serum lactate concentration after adjusting for asthma severity."	9.19	Albuterol administration is commonly associated with increases in serum lactate in patients with asthma treated for acute exacerbation of asthma. ( Aubuchon, K; Ferguson, I; House, SL; Johnson, K; Lewis, LM; Matsuda, K; Schneider, J, 2014)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	9.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4."	7.91	Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019)
"PLGA/chitosan nanospheres encapsulating metronidazole or PTB showed potential for modulating periodontitis progression."	7.88	Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018)
"Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)."	7.88	Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018)
"Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)."	7.85	Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017)
" Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus."	7.75	In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009)
"Type B lactic acidosis is rare among patients with malignant diseases."	7.71	Multiple myeloma associated with lactic acidosis. ( Burgess, R; Dainer, P; Fall, P; Hendricks, L; Jillella, A; Szerlip, HM; Ustun, C, 2002)
" However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin."	5.39	Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013)
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors."	5.37	Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011)
"Plasma albuterol was significantly correlated with serum lactate concentration after adjusting for asthma severity."	5.19	Albuterol administration is commonly associated with increases in serum lactate in patients with asthma treated for acute exacerbation of asthma. ( Aubuchon, K; Ferguson, I; House, SL; Johnson, K; Lewis, LM; Matsuda, K; Schneider, J, 2014)
"We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial."	5.13	Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008)
"We sought to measure the temporal evolution and spatial distribution of lesion macromolecules and small molecules (lactate, N-acetyl compounds, creatine, and choline) in stroke patients by using short echo time in vivo proton MR spectroscopy."	5.09	Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. ( Graham, GD; Hwang, JH; Prichard, JW; Rothman, DL, 2001)
" As S-adenosylhomocysteine (SAH) was shown to reflect tissue hypoxia, we compared the ability of SAH versus lactate to predict the progression of inflammatory and septic disease to septic organ dysfunction and death."	4.31	S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. ( Brohm, K; Centner, FS; Fuderer, T; Hahn, B; Jäger, E; Krebs, J; Lindner, HA; Mindt, S; Neumaier, M; Schneider-Lindner, V; Schoettler, JJ; Thiel, M, 2023)
"Gap acidosis except lactic acidosis developed and progressed during the CKD stage G5, while lactic acidosis developed in the CKD stages G1-4."	3.91	Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. ( Tanemoto, M, 2019)
"PLGA/chitosan nanospheres encapsulating metronidazole or PTB showed potential for modulating periodontitis progression."	3.88	Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018)
" c-MYC also regulates glutamine metabolism and drives progression of asymptomatic precursor plasma cell (PC) malignancies to symptomatic multiple myeloma (MM)."	3.88	Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies. ( Dutta, T; Ghosh, T; Gonsalves, WI; Hitosugi, T; Jevremovic, D; Kumar, SK; Nair, KS; Petterson, XM; Ramakrishnan, V; Sakrikar, D; Wellik, L, 2018)
"Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)."	3.88	Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018)
"Melatonin has a beneficial role in adult rat models of multiple sclerosis (MS)."	3.85	Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. ( Dokoohaki, S; Farhadi, N; Ghanbari, A; Ghareghani, M; Ghavamizadeh, M; Khodadoust, S; Parishani, M; Sadeghi, H; Zibara, K, 2017)
"In this study, blood redox potential (ORP) values (ΔORP value was adopted, as the quantitative index to reflect the overall redox status), plasma uric acid levels (important antioxidant, as antioxidant index), and the burn shock state-related indicators (lactic acid and hematocrit) of 48 burn patients were dynamically, quantitatively monitored during the early stage after injury."	3.81	The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. ( Han, C; Hu, H; Hu, X; Pan, X; Shao, H; Xu, J; Yu, C; Zhi, L, 2015)
" Here, we present data using in vivo magnetic resonance spectroscopy (MRS) optimized for the detection of glutamate to identify changes that evolve following kainic acid (KA)-induced status epilepticus."	3.75	In vivo glutamate decline associated with kainic acid-induced status epilepticus. ( Crawford, EL; Hsu, O; Mayer, D; Pfefferbaum, A; Rohlfing, T; Sullivan, EV; Vinco, S; Zahr, NM, 2009)
" We recently encountered a patient with a mysterious lactic acidosis."	3.73	Lactate in a laubenpieper. ( Claus, T; Derer, W; Elitok, S; Kettritz, R; Luft, FC; Pilz, B; Ruf, R; Schütt, H, 2005)
"Three unrelated, sporadic patients with muscle coenzyme Q10 (CoQ10) deficiency presented at 32, 29, and 6 years of age with proximal muscle weakness and elevated serum creatine kinase (CK) and lactate levels, but without myoglobinuria, ataxia, or seizures."	3.73	Coenzyme Q10 deficiency and isolated myopathy. ( DiMauro, S; Gempel, K; Horvath, R; Lochmüller, H; Müller-Höcker, J; Naini, A; Neuen-Jacob, E; Plöger, H; Pongratz, DE; Schneiderat, P; Schoser, BG, 2006)
" Primary central nervous system lymphoma (PCNSL) is a highly aggressive tumor responsive to high-dose methotrexate based regimens."	3.73	Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. ( Abrey, LE; DeAngelis, LM; Koutcher, JA; Lis, E; Panageas, KS; Raizer, JJ; Xu, S; Zakian, KL, 2005)
" Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination."	3.72	Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003)
"The mechanism of neurological disturbances in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is controversial."	3.72	Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. ( Abe, K; Fujita, N; Hikita, T; Sakoda, S; Tanaka, H; Yoshimura, H, 2004)
"Lactic acidosis and increased production of CO(2) are common in septic shock."	3.72	Increased tissue oxygen extraction and acidosis with progressive severity of sepsis. ( Chinkes, DL; Gore, DC; Hart, DW, 2003)
"Type B lactic acidosis is rare among patients with malignant diseases."	3.71	Multiple myeloma associated with lactic acidosis. ( Burgess, R; Dainer, P; Fall, P; Hendricks, L; Jillella, A; Szerlip, HM; Ustun, C, 2002)
"Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients."	2.75	A phase II study of an herbal decoction that includes Astragali radix for cancer-associated anorexia in patients with advanced cancer. ( Lee, JJ, 2010)
"Proliferating cancer cells have high energy demands, which is mainly obtained through glycolysis."	2.72	In Vivo Anticancer Activity of AZD3965: A Systematic Review. ( Afonso, J; Antunes, B; Baltazar, F; Batista, A; Pinto-Ribeiro, F; Silva, A, 2021)
"Cancer is the second most important cause of death and new therapy modalities continue to be developed and evolved."	2.66	Crucial players in glycolysis: Cancer progress. ( Abbaszadeh, Z; Biray Avcı, Ç; Çeşmeli, S, 2020)
"Sarcomas are rare and heterogeneous malignant tumors relatively resistant to radio- and chemotherapy."	2.66	Lactate in Sarcoma Microenvironment: Much More than just a Waste Product. ( Chiarugi, P; Leo, A; Pietrovito, L; Taddei, ML, 2020)
"Both cancer and diabetes have been associated with abnormal lactate metabolism and high level of lactate production is the key biological property of these diseases."	2.53	Lactate, a Neglected Factor for Diabetes and Cancer Interaction. ( Atefi, M; Dong, Y; Elshimali, Y; Liu, Y; Vadgama, JV; Wu, Y, 2016)
"Interaction between cancer cells and immune system critically affects development, progression and treatment of human malignancies."	2.50	"In vitro" 3D models of tumor-immune system interaction. ( Hirt, C; Iezzi, G; Martin, I; Mele, V; Mengus, C; Muraro, MG; Papadimitropoulos, A; Spagnoli, GC; Terracciano, L, 2014)
"Given its pleiotropic effects on cancer biology, PKM2 represents an attractive target for cancer therapy."	2.48	Emerging roles of PKM2 in cell metabolism and cancer progression. ( Luo, W; Semenza, GL, 2012)
"Sepsis is a dreaded complication in patients with postcardiotomy cardiogenic shock, especially ECMO-associated sepsis."	1.91	( Abdullatif, MT; Aboughanima, MA; Albabtain, MA; AlBarak, MM; Arafat, AA; Azar, B; Belghith, M; Elshoura, YA; Gross, I; Hashavya, S; Ohana Sarna Cahan, L; Osman, AA; Reif, S; Tantway, TM, 2023)
"Lip cyanosis is an important initial symptom in LS."	1.72	Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report. ( Cao, L; Feng, J; Huang, W; Men, L; Sun, R; Xu, J; Xu, M; Zhao, X, 2022)
"However, its role in breast cancer cell glucose metabolism was unclear."	1.62	Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021)
"Lung cancer is the leading cause of cancer death worldwide, and the carcinogens in tobacco smoke play a role in its progression and metastasis."	1.62	Cigarette smoke extract reduces FOXO3a promoting tumor progression and cell migration in lung cancer. ( Buscetta, M; Cipollina, C; Di Vincenzo, S; Ferraro, M; Pace, E; Sangiorgi, C, 2021)
"However, the function of SETD1A in gastric cancer (GC) progression and its role in GC metabolic reprogramming are still largely unknown."	1.56	Histone methyltransferase SETD1A interacts with HIF1α to enhance glycolysis and promote cancer progression in gastric cancer. ( Chai, H; Gu, Y; Wu, J; Xu, X; Yu, J, 2020)
"Gastric cancer is a major cause of mortality worldwide."	1.56	SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway. ( Awaleh Moumin, F; Cai, J; Chen, J; Chen, X; Jia, L; Xu, L, 2020)
"The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts."	1.51	Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. ( Chen, Y; Huang, C; Jiang, E; Liu, K; Liu, Q; Shang, Z; Shao, Z; Wang, H; Wang, L; Wang, M; Xu, Z; Yan, T; Zhou, X, 2019)
"Background Sepsis is the overwhelming host response to infection leading to shock and multiple organ dysfunction."	1.51	Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. ( Bauer, M; Bonios, MJ; de Lucia, C; Drosatos, K; Hoffman, M; Koch, WJ; Kyriazis, ID; Lucchese, AM; Piedepalumbo, M; Schulze, PC, 2019)
"Disease progression was identified using a composite endpoint of 28-day mortality, ICU admission and hospitalisation > 10 days."	1.51	The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. ( Amin, D; Beau, N; Bernardini, S; Bloos, F; Brandi, A; Callejo, CC; Chan, L; Claessens, YE; Cortes, N; Del Castillo, JG; Dryden, M; Hausfater, P; Kutz, A; Legramante, JM; Limper, M; Macchi, MA; Melander, O; Minieri, M; Mueller, B; Patka, P; Rood, PPM; Rosenqvist, M; Saeed, K; Schuetz, P; van der Does, Y; van Gorp, ECM; White, G; Wilson, DC; Yañez, MC, 2019)
"Leigh syndrome is a mitochondrial disease caused by respiratory chain deficiency, and there are no proven effective therapies."	1.48	Japanese Leigh syndrome case treated with EPI-743. ( Goto, T; Iai, M; Klein, MB; Kouga, T; Miller, G; Miyauchi, A; Murayama, K; Osaka, H; Shimbo, H; Takagi, M; Yamashita, S, 2018)
"Out of 410 severe sepsis admissions, 20 patients experienced early death."	1.46	Clinical predictors of early death from sepsis. ( Bowman, J; Guirgis, FW; Javed, A; Jones, AE; Puskarich, MA; Robinson, T; Sterling, SA, 2017)
"To investigate, in patients with Alzheimer's Disease (AD), the possible interplay linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) lactate concentration, to severity of AD neurodegenerative processes and impairment of cognitive abilities."	1.42	CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease. ( Liguori, C; Marciani, MG; Pierantozzi, M; Sancesario, G; Sancesario, GM; Stefani, A, 2015)
"Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance."	1.42	Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. ( Bhat, MK; Chaube, B; Malvi, P; Meena, AS; Mohammad, N; Singh, SV, 2015)
"We hypothesized that the progression of bladder cancer could be accompanied by changes in cells glycolytic profile."	1.42	The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism. ( Alves, MG; Conde, VR; Nunes, AR; Oliveira, PF; Pereira, JA; Ramalhosa, E; Rocha, CS; Silva, BM, 2015)
"Systemic arterial hypertension has been previously suggested to develop as a compensatory condition when central nervous perfusion/oxygenation is compromised."	1.42	Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. ( Ang, R; Gourine, AV; Hosford, PS; Karagiannis, A; Kasparov, S; Kasymov, V; Machhada, A; Marina, N; Mosienko, V; Paton, JF; Teschemacher, AG; Vihko, P, 2015)
"An altered metabolism during ovarian cancer progression allows for increased macromolecular synthesis and unrestrained growth."	1.40	Ovarian tumor-initiating cells display a flexible metabolism. ( Anderson, AS; Frisard, MI; Hulver, MW; Roberts, PC; Schmelz, EM, 2014)
""Cryptic shock" was defined as severe sepsis with a lactate level of 4 mmol/L or greater and normotension, "COS" was defined as initial CS that progressed to septic shock within 72 h, and "OS" was defined as septic shock on ED arrival."	1.40	Association between hemodynamic presentation and outcome in sepsis patients. ( Cha, WC; Hwang, SY; Jeon, K; Jeong, YK; Jo, IJ; Lee, TR; Shin, TG; Sim, MS; Song, KJ; Suh, GY, 2014)
"Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events."	1.40	Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014)
"We identified 423 patients with severe sepsis and electronically recorded continuous hemodynamic data in the prospective observational FINNAKI study."	1.39	Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. ( Hautamäki, R; Hovilehto, S; Inkinen, O; Karlsson, S; Kaukonen, KM; Korhonen, AM; Kuitunen, A; Laru-Sompa, R; Pettilä, V; Poukkanen, M; Uusaro, A; Vaara, ST; Wilkman, E, 2013)
"Cardiac hypertrophy is accompanied by significant alterations in energy metabolism."	1.39	Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. ( Jaswal, JS; Lopaschuk, GD; Sankaralingam, S; Ussher, JR; Wagg, C; Zaugg, M; Zhang, L, 2013)
" However, low peroral bioavailability is a major limiting factor for the success of clinical utilization of curcumin."	1.39	Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. ( Balakrishna, N; Grama, CN; Kumar, MN; Patil, MA; Raghu, G; Reddy, GB; Suryanarayana, P, 2013)
" Polymeric porous particles of PGE1 produced the same effects at a reduced dosing frequency compared to plain PGE1 and caused minimal off-target effects on systemic hemodynamics."	1.39	Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. ( Ahsan, F; Gupta, N; Gupta, V; Komatsu, M; McMurtry, IF; Mehvar, R; Nozik-Grayck, E; Oka, M; Shaik, IH, 2013)
"Proximal Spinal Muscular Atrophy (SMA) is a debilitating neuromuscular disease and a leading inherited genetic cause of infant death."	1.38	Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression. ( Beltran, JA; Charney, R; Chomicova, O; Cirillo, K; El-Khodor, BF; Marino, T; Mushlin, R; Ramboz, S; Winberg, ML, 2012)
"Recently, the clinical spectrum of dominant optic atrophy has been extended to frequent syndromic forms, exhibiting various degrees of neurological and muscle impairments frequently found in mitochondrial diseases."	1.38	The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. ( Angebault, C; Bielicki, G; Boddaert, N; Brabet, P; Cazevieille, C; Chaix, B; Delettre, C; Gueguen, N; Hamel, CP; Lenaers, G; Mausset-Bonnefont, AL; Puel, JL; Renou, JP; Reynier, P; Rigau, V; Sarzi, E; Seveno, M; Wang, J, 2012)
" Changes in mineral distribution effected by F were most pronounced in MeC lesions, with remineralization/mineral redeposition in the original lesion body at the expense of sound enamel beyond the original lesion in a dose-response manner."	1.38	Effect of fluoride, lesion baseline severity and mineral distribution on lesion progression. ( Butler, A; Hara, AT; Lippert, F; Lynch, RJ, 2012)
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors."	1.37	Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011)
"Five LB species were identified from carious dentine: L."	1.36	Diversity of Lactobacillus species in deep carious lesions of primary molars. ( Callaway, A; Kneist, S; Rupf, S; Schmidt, F; Thiede, B; Wicht, M; Willershausen, B, 2010)
"During septic shock, muscle produces lactate and pyruvate by way of an exaggerated Na(+), K(+)-ATPase-stimulated aerobic glycolysis associated with epinephrine stimulation."	1.36	Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patients. ( Gerard, A; Gibot, S; Levy, B; Perez, P, 2010)
"Diabetic retinopathy is one of the most common complications in diabetes mellitus due to persistent hyperglycaemia."	1.35	Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy. ( Baidya, KP; Bandyopadhyay, R; Bhaduri, G; Bhattacharya, B; Mondal, LK, 2008)
"Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion."	1.35	Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. ( Baik, SK; Chang, KH; Cho, BM; Choi, SH; Kim, DH; Kim, HJ; Kim, YW; Lee, JW; Lee, SH, 2008)
"He was diagnosed as having familial hemophagocytic lymphohistiocytosis and treated with the HLH 2004 protocol."	1.35	Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis. ( Gibikote, S; Kumar, S; Moses, PD; Puliyel, MM; Rose, W, 2009)
"The pathomechanisms of transient global amnesia (TGA) remain enigmatic."	1.35	Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia. ( Alfke, K; Bartsch, T; Deuschl, G; Jansen, O; Rohr, A; Wolff, S, 2008)
"Fifty patients of type 2 diabetes mellitus of 10-12 years duration, without retinopathy, constituted the study group."	1.33	Relation between increased anaerobic glycolysis and visual acuity in long-standing type 2 diabetes mellitus without retinopathy. ( Baidya, KP; Bhaduri, G; Bhattacharya, B; Giri, A; Mondal, LK, 2006)
"Two weeks after induction of hydrocephalus the taurine concentration was decreased, whereas the concentration of [1,2-13C]lactate was increased in the cerebrum and that of [1,2-13C]GABA in the brainstem."	1.32	Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. ( Brinker, T; Kondziella, D; Lüdemann, W; Qu, H; Sletvold, O; Sonnewald, U, 2003)
"Whole gut washout for acute pancreatitis appears effective to ameliorate the prognostic factors in blood and this modality may be a promising treatment method in acute pancreatitis."	1.31	Whole gut washout ameliorates the progression of acute experimental pancreatitis. ( Aksoy, F; Ozer, S; Vatansev, C; Yol, S, 2000)
"Although there seems to be a gene dosage effect in MERRF, we found no absolute relationship between the relative proportion of mutant genomes in blood and clinical severity."	1.30	Gene dosage effect in one family with myoclonic epilepsy and ragged-red fibers (MERRF). ( Arenas, J; Arpa, J; Barreiro, P; Campos, Y; Cruz-Martínez, A; Gutiérrez-Molina, M; Lacasa, T; López-Pajares, R; Martin-Casanueva, MA; Morales, MC; Pérez-Conde, MC; Tatay, J, 1997)
"Progressive graded hypoxemia was induced by decreasing fractional inspiratory oxygen concentration (FIO2) from 1."	1.30	Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. ( Blanco, CE; Maertzdorf, WJ; van der Hoeven, MA, 1997)
"Osteomyelitis is generally treated by the systemic administration of antibiotics and continuous irrigation after curettage of the lesion, and bone graft is performed secondarily to treat any bone defect."	1.30	Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis. ( Ishii, Y; Sasaki, S, 1999)
"Free carnitine levels were progressively decreased at 3 w (74% of control values) and at 6 w (57% of control values)."	1.29	Cardiac energy metabolism at several stages of adriamycin-induced heart failure in rats. ( Ishii, Y; Kawasaki, N; Lee, JD; Shimizu, H; Ueda, T, 1996)
"Aluminium aerosol treatment of silicosis after radiographic recognition of disease and the end of exposure did not alter the disease process."	1.29	Further information on aluminium inhalation in silicosis. ( Bégin, R; Dufresne, A; Massé, S, 1995)

Research

Studies (176)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Change of FEV1 (Forced Expiratory Volume in 1 Second) Expressed as Percent of Predicted After Two Doses of Albuterol (5 mg Each) and Ipratropium (0.5 mg Each) When Compared to FEV1 at Hour 2 After the Start of the Infusion of MN-221 or Placebo.

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (6.25)	18.2507
2000's	49 (27.84)	29.6817
2010's	88 (50.00)	24.3611
2020's	28 (15.91)	2.80

Authors	Studies
Silva, A	1
Antunes, B	1
Batista, A	1
Pinto-Ribeiro, F	1
Baltazar, F	2
Afonso, J	1
Wongkittichote, P	1
Magistrati, M	1
Shimony, JS	1
Smyser, CD	1
Fatemi, SA	1
Fine, AS	1
Bellacchio, E	1
Dallabona, C	1
Shinawi, M	1
Men, L	1
Feng, J	1
Huang, W	1
Xu, M	2
Zhao, X	1
Sun, R	1
Xu, J	2
Cao, L	1
Tantway, TM	1
Arafat, AA	1
Albabtain, MA	1
Belghith, M	1
Osman, AA	1
Aboughanima, MA	1
Abdullatif, MT	1
Elshoura, YA	1
AlBarak, MM	1
Azar, B	1
Hashavya, S	1
Ohana Sarna Cahan, L	1
Reif, S	1
Gross, I	1
Centner, FS	1
Schoettler, JJ	1
Brohm, K	1
Mindt, S	1
Jäger, E	1
Hahn, B	1
Fuderer, T	1
Lindner, HA	1
Schneider-Lindner, V	1
Krebs, J	1
Neumaier, M	1
Thiel, M	1
El-Kenawi, A	1
Gatenbee, C	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
A Prospective Long-term Observational Study in Patients With Monoclonal Gammopathy of Undetermined Significance[NCT05539079]		2,000 participants (Anticipated)	Observational	2023-09-06	Recruiting
ADAPTED: Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department[NCT03992794]		684 participants (Actual)	Observational [Patient Registry]	2018-03-15	Completed
A Phase II, Randomized, Modified Single-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of MN-221 When Administered Intravenously as an Adjunct to Standard Therapy to Adults With an Acute Exacerbation of Asthma[NCT00683449]	Phase 2	29 participants (Actual)	Interventional	2008-06-30	Terminated (stopped due to Data from Dose Groups 1,2 and other MN-221 studies resulted in the determination of a more appropriate dosing scheme for MN-221 in subjects with asthma.)
The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies[NCT05145049]		110 participants (Actual)	Observational [Patient Registry]	2021-11-01	Completed
Nutritional Assessment in Patients Affected by Mitochondrial Cytopathy[NCT02375438]		26 participants (Actual)	Observational	2014-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The primary efficacy summary was change from Baseline in FEV1 (percent predicted), at Hour 2. Baseline was defined as FEV1 (percent predicted) after two doses of albuterol (5 mg each) and ipratropium (0.5 mg each) and FEV1 (percent predicted) FEV1 at Hour 2 was defined as the FEV1 (percent predicted) at 2 hours after the start of the infusion of MN-221 or placebo. Change from Baseline in FEV1 (percent predicted), was summarized by treatment group at Hour 2. (NCT00683449)
Timeframe: Baseline and Hour 2

FEV1 (L) The Forced Expiratory Volume in One Second as Measured in Liters Per Second.

Intervention	FEV1 (percent of predicted) (Mean)
240 μg MN-221 i.v. (Intravenous) Infusion for 15 Minutes	16.57
MN-221 Placebo i.v. Infusion	3.88
1,000-1,080 μg MN-221 i.v.	3.03
450 μg MN-221 i.v. for 15 Minutes	4.27
1,995 μg MN-221 i.v. Over 15 Minutes and 25 Minutes	-0.82

FEV1 (L) was determined over time using a spirometer. Measure the mean change in FEV1 (L) from Baseline. (NCT00683449)
Timeframe: Baseline to Hour 2

Hospital Admission Rate During Visit 1

Intervention	liters per second (Mean)
MN-221 at 16.0 μg/Min for 15 Min (Total 240 μg)	0.60
Placebo Administered Intravenously	0.10
450 μg MN-221 Given i.v.	0.12
1,000-1,080 μg MN-221 Given i.v. for 15 Minutes	0.10
1,995 MN-221 Administered i.v. for 15 Minutes and 25 Minutes	-0.02

After a patient in the emergency department (ED) presents with an acute exacerbation of asthma, the hospital proceeds with SOC procedures for this condition. Despite treatment in the ED, it is sometimes necessary to admit the patient into the hospital. In the study described here, the rate of hospital admissions was recorded. (NCT00683449)
Timeframe: Hour -1.5 through Hour 5

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"In vitro" 3D models of tumor-immune system interaction. Advanced drug delivery reviews, 2014, Dec-15, Volume: 79-80 Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Cytokines; Disease Progression	2014
Lactate, a Neglected Factor for Diabetes and Cancer Interaction. Mediators of inflammation, 2016, Volume: 2016 Topics: Animals; Cell Line, Tumor; Diabetes Complications; Diabetes Mellitus; Disease Progression; Humans; H	2016
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A phase II study of an herbal decoction that includes Astragali radix for cancer-associated anorexia in patients with advanced cancer. Integrative cancer therapies, 2010, Volume: 9, Issue:1 Topics: Aged; Anorexia; Astragalus Plant; Body Weight; Cytokines; Disease Progression; Drugs, Chinese Herbal	2010
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study. Stroke, 2003, Volume: 34, Issue:7 Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffu	2003
Spectroscopic assessment of alterations in macromolecule and small-molecule metabolites in human brain after stroke. Stroke, 2001, Dec-01, Volume: 32, Issue:12 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Choline; Creatine; Disease Progression; Female;	2001

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Functional analysis of missense DARS2 variants in siblings with leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Molecular genetics and metabolism, 2022, Volume: 136, Issue:4 Topics: Adolescent; Adult; Aspartate-tRNA Ligase; Ataxia; Brain Stem; Disease Progression; Humans; Lactic Ac	2022
Lip cyanosis as the first symptom of Leigh syndrome associated with mitochondrial complex I deficiency due to a compound heterozygous NDUFS1 mutation: A case report. Medicine, 2022, Aug-26, Volume: 101, Issue:34 Topics: Child; Cyanosis; Disease Progression; Electron Transport Complex I; Humans; Infant; Infant, Newborn;	2022
The International journal of artificial organs, 2023, Volume: 46, Issue:3 Topics: Bronchiolitis; Cardiac Surgical Procedures; Disease Progression; Extracorporeal Membrane Oxygenation	2023
S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. International journal of molecular sciences, 2023, Aug-09, Volume: 24, Issue:16 Topics: Critical Illness; Disease Progression; Humans; Hypoxia; Lactic Acid; Multiple Organ Failure; Oxygen;	2023
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. British journal of cancer, 2019, Volume: 121, Issue:7 Topics: Animals; Bicarbonates; Cell Line, Tumor; Computer Simulation; Cytokines; Disease Progression; Extrac	2019
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production. Cell biology international, 2020, Volume: 44, Issue:2 Topics: Adolescent; Adult; Aldehyde Oxidoreductases; Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms;	2020
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Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells. Oncotarget, 2017, Apr-11, Volume: 8, Issue:15 Topics: Aerobiosis; Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Progression; G	2017
Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Scientific reports, 2017, 06-27, Volume: 7, Issue:1 Topics: Acriflavine; Animals; Basigin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Disease	2017
Clinical predictors of early death from sepsis. Journal of critical care, 2017, Volume: 42 Topics: Adult; Aged; Disease Progression; Emergency Service, Hospital; Female; Hospitalization; Humans; Lact	2017
JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression. BMC cancer, 2017, Jul-11, Volume: 17, Issue:1 Topics: Adenosine Triphosphate; Adult; Aged; Biomarkers; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Pr	2017
Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. Journal of periodontal research, 2018, Volume: 53, Issue:1 Topics: Animals; Anti-Infective Agents; Chitosan; Disease Models, Animal; Disease Progression; Lactic Acid;	2018
CSF profile in primary progressive multiple sclerosis: Re-exploring the basics. PloS one, 2017, Volume: 12, Issue:8 Topics: Adult; Biomarkers; Disease Progression; Female; Humans; Immunoglobulin G; Lactic Acid; Male; Middle	2017
Japanese Leigh syndrome case treated with EPI-743. Brain & development, 2018, Volume: 40, Issue:2 Topics: Antioxidants; Brain; Child, Preschool; Disease Progression; Electron Transport Complex I; Female; Hu	2018
Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies. JCI insight, 2018, 01-11, Volume: 3, Issue:1 Topics: Biomarkers, Tumor; Cell Line, Tumor; Citric Acid Cycle; Disease Progression; DNA-Binding Proteins; G	2018
Increased blood lactate is prevalent and identifies poor prognosis in patients with acute heart failure without overt peripheral hypoperfusion. European journal of heart failure, 2018, Volume: 20, Issue:6 Topics: Acute Disease; Aged; Biomarkers; Disease Progression; Female; Heart Failure; Humans; Lactic Acid; Ma	2018
Muscular endurance and progression rates of early-stage invasive ductal carcinoma: A pilot study. The breast journal, 2018, Volume: 24, Issue:5 Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Case-Control Studies; Disease Progression;	2018
Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Molecular imaging and biology, 2019, Volume: 21, Issue:1 Topics: Animals; Disease Models, Animal; Disease Progression; Heterografts; Humans; Image Enhancement; Lacti	2019
The Preseptic Period and Inflammatory Markers in the Prediction of the Course of Sepsis. Medical science monitor : international medical journal of experimental and clinical research, 2018, May-27, Volume: 24 Topics: Bacteria; Biomarkers; Bronchoalveolar Lavage Fluid; Calcitonin; Case-Control Studies; Demography; Di	2018
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. The British journal of nutrition, 2018, Volume: 120, Issue:2 Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto	2018
Serum Lactate Levels as a Prognostic Predictor of Septic Shock in Emergency Department Patients with Systemic Inflammatory Response Syndrome (SIRS) at Songklanagarind Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2016, Volume: 99, Issue:8 Topics: Aged; Biomarkers; Disease Progression; Emergency Service, Hospital; Female; Humans; Lactic Acid; Mal	2016
Age-adjusted CSF β2-microglobulin and lactate are increased and ACE is decreased in patients with multiple sclerosis, but only lactate correlates with clinical disease duration and severity. Journal of neuroimmunology, 2018, 10-15, Volume: 323 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; beta 2-Microglobulin; Biomarkers; Cohort St	2018
ATM deficiency promotes progression of CRPC by enhancing Warburg effect. Endocrine-related cancer, 2019, 01-01, Volume: 26, Issue:1 Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cell Proliferation; Disease Progr	2019
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions. Journal of immunology (Baltimore, Md. : 1950), 2019, 01-15, Volume: 202, Issue:2 Topics: Acriflavine; Active Transport, Cell Nucleus; Animals; Anti-Infective Agents, Local; Basic Helix-Loop	2019
A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures. Magnetic resonance in medicine, 2019, Volume: 81, Issue:5 Topics: Animals; Bioreactors; Cell Line, Tumor; Cell Survival; Collagen; Contrast Media; Diffusion; Disease	2019
Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy. Magnetic resonance imaging, 2019, Volume: 58 Topics: Alleles; Animals; Biomarkers; Brain; Disease Models, Animal; Disease Progression; Electron Transport	2019
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:4 Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Caveolin 1; Cell Line, Tumor; Cocu	2019
The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study. Critical care (London, England), 2019, Feb-08, Volume: 23, Issue:1 Topics: Adolescent; Adrenomedullin; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; C-Reactive	2019
Gap acidosis except lactic acidosis develops and progresses during chronic kidney disease stage G5. Clinical and experimental nephrology, 2019, Volume: 23, Issue:8 Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Lactic; Aged; Aged, 80 and over; Biomarkers; Disease Prog	2019
Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. Journal of the American Heart Association, 2019, 05-21, Volume: 8, Issue:10 Topics: Animals; Biomarkers; Cardiac Output; Cardiomyopathies; Cytokines; Disease Models, Animal; Disease Pr	2019
Inhaled PLGA particles of prostaglandin E₁ ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Molecular pharmaceutics, 2013, May-06, Volume: 10, Issue:5 Topics: Administration, Inhalation; Alprostadil; Animals; Delayed-Action Preparations; Disease Models, Anima	2013
Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Experimental cell research, 2013, Jun-10, Volume: 319, Issue:10 Topics: Animals; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Respiration; Cholesterol; Citrate (si	2013
Impaired information-processing speed and working memory in leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) and DARS2 mutations: a report of three adult patients. Journal of neurology, 2013, Volume: 260, Issue:8 Topics: Adolescent; Age of Onset; Aspartate-tRNA Ligase; Brain Stem; Child; Cognition; Disease Progression;	2013
Ischemic stroke penumbra and extracorporeal ozone treatment. The neuroradiology journal, 2013, Volume: 26, Issue:3 Topics: Adenosine Triphosphate; Apoptosis; Brain Edema; Disabled Persons; Disease Progression; Glutathione R	2013
Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circulation. Heart failure, 2013, Sep-01, Volume: 6, Issue:5 Topics: Adenosine Triphosphate; Animals; Aorta, Abdominal; Arterial Pressure; Blood Glucose; Cardiomegaly; D	2013
Generalized acanthosis nigricans without systemic disease associated. Dermatology online journal, 2013, Sep-14, Volume: 19, Issue:9 Topics: Acanthosis Nigricans; Adolescent; Dermatologic Agents; Disease Progression; Drug Therapy, Combinatio	2013
Magnetic resonance imaging spectroscopy in pediatric atypical teratoid rhabdoid tumors of the brain. Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:6 Topics: Brain; Brain Neoplasms; Child, Preschool; Choline; Chromosomal Proteins, Non-Histone; Creatine; Diag	2014
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. International immunology, 2014, Volume: 26, Issue:2 Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis	2014
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PloS one, 2013, Volume: 8, Issue:10 Topics: Aldehyde Reductase; Animals; Antioxidants; Biocompatible Materials; Biodegradation, Environmental; B	2013
Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. Critical care (London, England), 2013, Dec-13, Volume: 17, Issue:6 Topics: Acute Kidney Injury; Blood Pressure; Disease Progression; Dobutamine; Furosemide; Hemodynamics; Huma	2013
Excitotoxicity and metabolic changes in association with infarct progression. Stroke, 2014, Volume: 45, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Infarction; Disease Progression; Female; Glucose; Gl	2014
The noninvasive carbon dioxide gradient (NICO2G) during hemorrhagic shock. Shock (Augusta, Ga.), 2014, Volume: 42, Issue:1 Topics: Animals; Biomarkers; Blood Gas Monitoring, Transcutaneous; Breath Tests; Capnography; Carbon Dioxide	2014
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation. ACS nano, 2014, May-27, Volume: 8, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; C	2014
Association between hemodynamic presentation and outcome in sepsis patients. Shock (Augusta, Ga.), 2014, Volume: 42, Issue:3 Topics: Aged; Biomarkers; Blood Pressure; Chi-Square Distribution; Disease Progression; Emergency Service, H	2014
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry, 2015, Volume: 86, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition Disorders;	2015
Serum lactate as a potential biomarker of malignancy in primary adult brain tumours. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:1 Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Craniotomy; Disease Progression; Female; Glycolysis; Human	2015
Ovarian tumor-initiating cells display a flexible metabolism. Experimental cell research, 2014, Oct-15, Volume: 328, Issue:1 Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Disease	2014
A new aortic injury score predicts early rupture more accurately than clinical assessment. Journal of vascular surgery, 2015, Volume: 61, Issue:2 Topics: Adult; Aged; Aorta, Thoracic; Aortic Rupture; Aortography; Area Under Curve; Biomarkers; Decision Su	2015
Oxidized low-density lipoprotein stimulates macrophage 18F-FDG uptake via hypoxia-inducible factor-1α activation through Nox2-dependent reactive oxygen species generation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:10 Topics: Animals; Cell Line; Cell Membrane; Disease Progression; Fluorodeoxyglucose F18; Glucose Transporter	2014
Real-time assessment of ¹³C metabolism reveals an early lactate increase in the brain of rats with acute liver failure. NMR in biomedicine, 2015, Volume: 28, Issue:1 Topics: Alanine; Animals; Brain; Carbon; Carbon Isotopes; Computer Systems; Disease Progression; Lactic Acid	2015
Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity. Microbiology (Reading, England), 2015, Volume: 161, Issue:Pt 1 Topics: Animals; Antibiotics, Antineoplastic; Biodiversity; Diabetes Mellitus, Experimental; Diabetes Mellit	2015
The characteristics and correlation between the ischemia-reperfusion and changes of redox status in the early stage of severe burns. The American journal of emergency medicine, 2015, Volume: 33, Issue:3 Topics: Adult; Burns; Case-Control Studies; Cohort Studies; Disease Progression; Hematocrit; Humans; Hypoxia	2015
Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979), 2015, Volume: 65, Issue:4 Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Stem; Disease Models, Animal; Disease Progres	2015
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy. The Journal of pathology, 2015, Volume: 236, Issue:4 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Progression; Drug Desi	2015
The progression from a lower to a higher invasive stage of bladder cancer is associated with severe alterations in glucose and pyruvate metabolism. Experimental cell research, 2015, Jul-01, Volume: 335, Issue:1 Topics: Alanine; Alanine Transaminase; Cell Line, Tumor; Disease Progression; Glucose; Glucose Transporter T	2015
The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration, 2015, Volume: 16, Issue:7-8 Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Case-Control Studies; Citric Acid; Cohort Studies;	2015
Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. Oncotarget, 2015, Nov-10, Volume: 6, Issue:35 Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin	2015
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells. Lab on a chip, 2016, Jan-07, Volume: 16, Issue:1 Topics: Antineoplastic Agents; Biomechanical Phenomena; Breast Neoplasms; Cell Line, Tumor; Cell Proliferati	2016
Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression. Chinese medical journal, 2016, Jan-05, Volume: 129, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Analysis of Variance; Disease Progression; Female; Humans; Kap	2016
Derivation and Validation of Predictive Factors for Clinical Deterioration after Admission in Emergency Department Patients Presenting with Abnormal Vital Signs Without Shock. The western journal of emergency medicine, 2015, Volume: 16, Issue:7 Topics: Aged; Bicarbonates; Chronic Disease; Disease Progression; Emergency Service, Hospital; Health Status	2015
Pioglitazone-Incorporated Nanoparticles Prevent Plaque Destabilization and Rupture by Regulating Monocyte/Macrophage Differentiation in ApoE-/- Mice. Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:3 Topics: Administration, Intravenous; Angiotensin II; Animals; Apolipoproteins E; Atherosclerosis; Brachiocep	2016
Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression. Journal of neuroinflammation, 2016, Feb-10, Volume: 13 Topics: Adult; Case-Control Studies; Disability Evaluation; Disease Progression; Female; Humans; Lactic Acid	2016
Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure. European journal of heart failure, 2016, Volume: 18, Issue:7 Topics: Acute Disease; Aged; Aged, 80 and over; Anemia; Cause of Death; Cohort Studies; Disease Progression;	2016
Feasibility of induced metabolic bioluminescence imaging in advanced ovarian cancer patients: first results of a pilot study. Journal of cancer research and clinical oncology, 2016, Volume: 142, Issue:9 Topics: Aged; Aged, 80 and over; Carcinoma, Ovarian Epithelial; Disease Progression; Energy Metabolism; Feas	2016
Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases. Muscle & nerve, 2017, Volume: 55, Issue:4 Topics: Adult; Aged; Creatine Kinase; Disease Progression; DNA, Mitochondrial; Enzyme-Linked Immunosorbent A	2017
Melatonin exacerbates acute experimental autoimmune encephalomyelitis by enhancing the serum levels of lactate: A potential biomarker of multiple sclerosis progression. Clinical and experimental pharmacology & physiology, 2017, Volume: 44, Issue:1 Topics: Animals; Biomarkers; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Lacti	2017
In vivo imaging of the progression of acute lung injury using hyperpolarized [1- Magnetic resonance in medicine, 2017, Volume: 78, Issue:6 Topics: Acute Lung Injury; Animals; Carbon Isotopes; Disease Progression; Hydrochloric Acid; Image Processin	2017
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature. British journal of cancer, 2017, Mar-14, Volume: 116, Issue:6 Topics: Cell Proliferation; Disease Progression; Energy Metabolism; Game Theory; Glycolysis; Humans; Hydroge	2017
The cerebrospinal fluid lactate is decreased in early stages of multiple sclerosis. Puerto Rico health sciences journal, 2008, Volume: 27, Issue:2 Topics: Adult; Aged; Disease Progression; Female; Humans; Lactic Acid; Male; Middle Aged; Multiple Sclerosis	2008
Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. Journal of the neurological sciences, 2008, Dec-15, Volume: 275, Issue:1-2 Topics: Adult; Analysis of Variance; Disease Progression; Female; Fructose; Glucose; Humans; Lactic Acid; Ma	2008
Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy. Journal of the Indian Medical Association, 2008, Volume: 106, Issue:8 Topics: Anaerobic Threshold; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disea	2008
Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome. Metabolic syndrome and related disorders, 2009, Volume: 7, Issue:1 Topics: Adolescent; Adult; Aged; APACHE; Bicarbonates; Blood Glucose; Critical Illness; Disease Progression;	2009
Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats. Acta radiologica (Stockholm, Sweden : 1987), 2008, Volume: 49, Issue:10 Topics: Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models, Animal; Dise	2008
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study. Neurology, 2008, Dec-09, Volume: 71, Issue:24 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel	2008
Minimally invasive combined treatment for Parry-Romberg syndrome. Aesthetic plastic surgery, 2009, Volume: 33, Issue:3 Topics: Combined Modality Therapy; Disease Progression; Facial Hemiatrophy; Female; Freeze Drying; Humans; I	2009
Prolonged neurologic course of familial hemophagocytic lymphohistiocytosis. Pediatric neurology, 2009, Volume: 41, Issue:3 Topics: Aspartic Acid; Bone Marrow; Brain; Child; Choline; Diagnosis, Differential; Disease Progression; Fat	2009
In vivo glutamate decline associated with kainic acid-induced status epilepticus. Brain research, 2009, Dec-01, Volume: 1300 Topics: Analysis of Variance; Animals; Aspartic Acid; Disease Progression; Glutamic Acid; Hippocampus; Image	2009
Increased muscle-to-serum lactate gradient predicts progression towards septic shock in septic patients. Intensive care medicine, 2010, Volume: 36, Issue:10 Topics: Adolescent; Adult; Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Disease Progres	2010
Metabolic signatures of malignant progression in prostate epithelial cells. The international journal of biochemistry & cell biology, 2011, Volume: 43, Issue:7 Topics: Amino Acids; Animals; Biomarkers, Tumor; Cell Line; Choline; Disease Progression; Epithelial Cells;	2011
Diversity of Lactobacillus species in deep carious lesions of primary molars. European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2010, Volume: 11, Issue:4 Topics: Bacterial Load; Calcium Hydroxide; Child; Dental Caries; Dental Cavity Preparation; Dental Pulp Capp	2010
Detecting and treating sepsis in the emergency department. Journal of emergency nursing, 2011, Volume: 37, Issue:1 Topics: Anti-Bacterial Agents; Disease Progression; Early Diagnosis; Emergency Nursing; Emergency Service, H	2011
Rabbit rubeosis iridis induced by intravitreal latex-derived angiogenic fraction. Current eye research, 2011, Volume: 36, Issue:9 Topics: Angiogenesis Inducing Agents; Animals; Disease Models, Animal; Disease Progression; Drug Carriers; F	2011
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer, 2011, Jul-01, Volume: 117, Issue:13 Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol	2011
Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 9 Topics: Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured;	2011
Cancer: Sacrifice for survival. Nature, 2011, Dec-07, Volume: 480, Issue:7376 Topics: Anaerobiosis; Cell Respiration; Cell Survival; Disease Progression; Glycolysis; Humans; Lactic Acid;	2011
Role of active nitrogen molecules in progression of septic shock. Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:3 Topics: Adult; APACHE; Creatinine; Critical Care; Critical Illness; Disease Progression; Enzyme-Linked Immun	2012
Effect of fluoride, lesion baseline severity and mineral distribution on lesion progression. Caries research, 2012, Volume: 46, Issue:1 Topics: Acetic Acid; Animals; Apatites; Calcium Fluoride; Calcium Phosphates; Carboxymethylcellulose Sodium;	2012
Predicting factors associated with clinical deterioration of sepsis patients with intermediate levels of serum lactate. Shock (Augusta, Ga.), 2012, Volume: 38, Issue:3 Topics: Aged; Disease Progression; Female; Humans; Kaplan-Meier Estimate; Lactic Acid; Male; Middle Aged; Re	2012
Prediction of death in the SMNΔ7 mouse model of spinal muscular atrophy: insight into disease stage and progression. Journal of neuroscience methods, 2012, Aug-15, Volume: 209, Issue:2 Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Computer Simulation; Dichloroacetic Acid	2012
The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse. Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 12 Topics: Acoustic Stimulation; Age Factors; Aging, Premature; Animals; Aspartic Acid; Chi-Square Distribution	2012
Fetal sheep left ventricle is more sensitive than right ventricle to progressively worsening hypoxemia and acidemia. European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 167, Issue:2 Topics: Acidosis; Animals; Animals, Inbred Strains; Disease Models, Animal; Disease Progression; Female; Fin	2013
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis. Environmental health perspectives, 2002, Volume: 110 Suppl 5 Topics: Animals; Cell Cycle Proteins; Cell Hypoxia; Cell Transformation, Neoplastic; Disease Progression; DN	2002
Multiple myeloma associated with lactic acidosis. Leukemia & lymphoma, 2002, Volume: 43, Issue:12 Topics: Acidosis, Lactic; Disease Progression; Humans; Immunoglobulin G; Immunoglobulin kappa-Chains; Lactic	2002
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. Journal of neurology, 2003, Volume: 250, Issue:3 Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr	2003
Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. Journal of neurochemistry, 2003, Volume: 85, Issue:1 Topics: Acetates; Animals; Astrocytes; Biomarkers; Brain Stem; Carbon Isotopes; Disease Models, Animal; Dise	2003
Increased tissue oxygen extraction and acidosis with progressive severity of sepsis. The Journal of surgical research, 2003, Jun-01, Volume: 112, Issue:1 Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Carbon Dioxide; Disease Progression; Heart	2003
Restoration of sarcoplasmic reticulum protein level by thyroid hormone contributes to partial improvement of myocardial function, but not to glucose metabolism in an early failing heart. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2003, Volume: 24, Issue:4 Topics: Animals; Calcium-Transporting ATPases; Cells, Cultured; Disease Models, Animal; Disease Progression;	2003
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging. Radiology, 2003, Volume: 229, Issue:2 Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Co	2003
Alexander disease with serial MRS and a new mutation in the glial fibrillary acidic protein gene. Neurology, 2003, Oct-14, Volume: 61, Issue:7 Topics: Acidosis, Respiratory; Alexander Disease; Basal Ganglia; Choline; Creatine; Disease Progression; DNA	2003
Prevalence and progression of mitochondrial diseases: a study of 50 patients. Muscle & nerve, 2003, Volume: 28, Issue:6 Topics: Adolescent; Adult; Age of Onset; Aged; Disease Progression; DNA, Mitochondrial; Electromyography; Ep	2003
Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. Neuroradiology, 2004, Volume: 46, Issue:2 Topics: Adolescent; Adult; Cerebral Cortex; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; D	2004
Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology, 2004, Apr-13, Volume: 62, Issue:7 Topics: Adolescent; Aspartic Acid; Brain; Brain Diseases; Calcinosis; Central Nervous System Cysts; Child; C	2004
3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. Journal of neurochemistry, 2004, Volume: 89, Issue:5 Topics: Acute Disease; Animals; Behavior, Animal; Body Weight; Brain; Choline; Chronic Disease; Disease Mode	2004
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma. Journal of neurosurgery, 2004, Volume: 101, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor	2004
Proton magnetic resonance spectroscopy in immunocompetent patients with primary central nervous system lymphoma. Journal of neuro-oncology, 2005, Volume: 71, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Aspartic Acid; Central Nervous Syst	2005
Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. International journal of radiation oncology, biology, physics, 2005, May-01, Volume: 62, Issue:1 Topics: Aspartic Acid; Brain Stem Neoplasms; Child; Child, Preschool; Choline; Creatine; Disease Progression	2005
Lactate in a laubenpieper. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:12 Topics: Acidosis, Lactic; Beriberi; Biomarkers; Diagnosis, Differential; Disease Progression; Humans; Lactic	2005
Long-term follow-up of neonatal mitochondrial cytopathies: a study of 57 patients. Pediatrics, 2005, Volume: 116, Issue:5 Topics: Child, Preschool; Disease Progression; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; I	2005
Coenzyme Q10 deficiency and isolated myopathy. Neurology, 2006, Jan-24, Volume: 66, Issue:2 Topics: Adult; Coenzymes; Creatine Kinase; Delivery, Obstetric; Disease Progression; Electron Transport Comp	2006
A case of Melas (A3243G) on chronic dichloroacetate treatment. European neurology, 2006, Volume: 55, Issue:1 Topics: Adolescent; Brain Ischemia; Dichloroacetic Acid; Disease Progression; DNA Mutational Analysis; Domin	2006
Relation between increased anaerobic glycolysis and visual acuity in long-standing type 2 diabetes mellitus without retinopathy. Indian journal of ophthalmology, 2006, Volume: 54, Issue:1 Topics: Anaerobic Threshold; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Follow-Up	2006
Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis. Journal of child neurology, 2006, Volume: 21, Issue:2 Topics: Adolescent; Antiviral Agents; Artifacts; Aspartic Acid; Choline; Disease Progression; Dominance, Cer	2006
Increased lactate levels impair the coagulation system--a potential contributing factor to progressive hemorrhage after traumatic brain injury. Journal of neurosurgical anesthesiology, 2006, Volume: 18, Issue:3 Topics: Acidosis; Blood Coagulation; Brain Injuries; Buffers; Cerebral Hemorrhage, Traumatic; Disease Progre	2006
Nanoencapsulation of usnic acid: An attempt to improve antitumour activity and reduce hepatotoxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2006, Volume: 64, Issue:2 Topics: Animals; Benzofurans; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Disease Progression;	2006
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. Neurosurgical focus, 2000, Volume: 8, Issue:1 Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran	2000
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction. Stroke, 2007, Volume: 38, Issue:1 Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol	2007
Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats. Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 23, Issue:2-3 Topics: Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Brain; Cerebrovascular Circulation; Dis	2007
Familial, adult onset form of leukoencephalopathy with brain stem and spinal cord involvement: inconstant high brain lactate and very slow disease progression. European neurology, 2007, Volume: 58, Issue:1 Topics: Adult; Brain Chemistry; Brain Diseases; Brain Stem; Disease Progression; Family Health; Female; Huma	2007
Surgical algorithm for management of HIV lipodystrophy. Plastic and reconstructive surgery, 2007, Volume: 120, Issue:7 Topics: Adipose Tissue; Adult; Algorithms; Back; Cellulose; Disease Progression; Face; Gynecomastia; HIV-Ass	2007
Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia. Neurology, 2008, Mar-25, Volume: 70, Issue:13 Topics: Aged; Amnesia, Transient Global; Biomarkers; Diffusion Magnetic Resonance Imaging; Disease Progressi	2008
Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats. Journal of neurotrauma, 2008, Volume: 25, Issue:6 Topics: Aging; Alanine; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Injuries; Cell Respiration; C	2008
Further information on aluminium inhalation in silicosis. Occupational and environmental medicine, 1995, Volume: 52, Issue:11 Topics: Administration, Inhalation; Animals; Disease Progression; Lactates; Lactic Acid; Sheep; Silicosis	1995
Cardiac energy metabolism at several stages of adriamycin-induced heart failure in rats. International journal of cardiology, 1996, Volume: 55, Issue:3 Topics: Adenosine Triphosphate; Alanine; Animals; Cardiac Output, Low; Carnitine; Chromatography, High Press	1996
[Kallikrein-kinin indices and biological composition of exhaled condensate in acute bronchitis patients with varying disease course]. Klinicheskaia meditsina, 1996, Volume: 74, Issue:7 Topics: Acute Disease; Acute-Phase Proteins; Adolescent; Adult; Bronchitis; Disease Progression; Female; Hum	1996
Gene dosage effect in one family with myoclonic epilepsy and ragged-red fibers (MERRF). Acta neurologica Scandinavica, 1997, Volume: 96, Issue:2 Topics: Adult; Age of Onset; Creatine Kinase; Disease Progression; DNA, Mitochondrial; Female; Gene Dosage;	1997
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. Journal of neurosurgery, 1997, Volume: 87, Issue:4 Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas	1997
Mixed venous oxygen saturation and biochemical parameters of hypoxia during progressive hypoxemia in 10- to 14-day-old piglets. Pediatric research, 1997, Volume: 42, Issue:6 Topics: Animals; Disease Progression; Hypoxia; Lactic Acid; Linear Models; Oxygen; Pyruvic Acid; Swine; Vein	1997
Mitochondrial myopathy with atypical subacute presentation. Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:3 Topics: Acute Disease; Adult; Biopsy; Disease Progression; Electromyography; Female; Humans; Lactic Acid; Mi	1998
Hyperlactatemia during acute severe asthma. Intensive care medicine, 1998, Volume: 24, Issue:4 Topics: Acidosis, Lactic; Acute Disease; Adult; Arteries; Asthma; Blood Gas Analysis; Disease Progression; F	1998
Involvement of reactive oxygen species in membrane phospholipid breakdown and energy perturbation after traumatic brain injury in the rat. Journal of neurotrauma, 1998, Volume: 15, Issue:7 Topics: Analysis of Variance; Animals; Biomarkers; Brain Injuries; Disease Models, Animal; Disease Progressi	1998
Severity of experimental brain injury on lactate and free fatty acid accumulation and Evans blue extravasation in the rat cortex and hippocampus. Journal of neurotrauma, 1999, Volume: 16, Issue:6 Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Cerebral Cortex; Coloring Agents; Disease Models	1999
Apatite cement containing antibiotics: efficacy in treating experimental osteomyelitis. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 1999, Volume: 4, Issue:5 Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Apatites; Bone Cements; Bone Marrow; Bone T	1999
Whole gut washout ameliorates the progression of acute experimental pancreatitis. American journal of surgery, 2000, Volume: 180, Issue:2 Topics: Acute Disease; Alanine Transaminase; Amylases; Animals; Bicarbonates; Blood Glucose; Calcium; Diseas	2000
Low molecular weight chitosan prevents the progression of low dose streptozotocin-induced slowly progressive diabetes mellitus in mice. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:12 Topics: Administration, Oral; Animals; Blood Glucose; Chitin; Chitosan; Diabetes Mellitus, Experimental; Dis	2000
The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage. Journal of neurotrauma, 2001, Volume: 18, Issue:1 Topics: Animals; Axons; Blood Pressure; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cardiac Outpu	2001
Ocular blood flow and retinal metabolism in abyssinian cats with hereditary retinal degeneration. Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:5 Topics: Animals; Blood Flow Velocity; Blood Glucose; Cardiovascular Agents; Cats; Choroid; Disease Models, A	2001
Hepatic transport of gluconeogenic substrates during tumor growth in the rat. Cancer investigation, 2001, Volume: 19, Issue:3 Topics: Alanine; Animals; Diffusion; Disease Progression; Female; Glucose; Glycerol; Kinetics; Lactic Acid;	2001
Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: a novel treatment strategy for induction of oral tolerance. Arthritis and rheumatism, 2002, Volume: 46, Issue:4 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmunity; Biocompatible Materials; Catt	2002

lactic acid and Disease Exacerbation