lactic acid has been researched along with Diabetic Retinopathy in 17 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary aim of these experiments was to assess in vitro effects of hyperglycemia (30 mmol/l glucose) and hypoxia (Po(2) = 36 torr) of 2-h duration, separately and in combination, on cytosolic and mitochondrial free NADH (NADHc and NADHm, respectively) in retinas from normal rats." | 3.72 | Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. ( Ido, Y; Kilo, C; Nyengaard, JR; Williamson, JR, 2004) |
| "Diabetic retinopathy is one of the most common complications in diabetes mellitus due to persistent hyperglycaemia." | 1.35 | Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy. ( Baidya, KP; Bandyopadhyay, R; Bhaduri, G; Bhattacharya, B; Mondal, LK, 2008) |
| "Fifty patients of type 2 diabetes mellitus of 10-12 years duration, without retinopathy, constituted the study group." | 1.33 | Relation between increased anaerobic glycolysis and visual acuity in long-standing type 2 diabetes mellitus without retinopathy. ( Baidya, KP; Bhaduri, G; Bhattacharya, B; Giri, A; Mondal, LK, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Mieno, H | 1 |
| Marunaka, Y | 1 |
| Inaba, T | 1 |
| Kojima, K | 1 |
| Yoneda, K | 1 |
| Nagata, K | 1 |
| Sotozono, C | 1 |
| Rajala, A | 1 |
| Soni, K | 1 |
| Rajala, RVS | 1 |
| Mondal, LK | 3 |
| Bhaduri, G | 3 |
| Bhattacharya, B | 4 |
| Simsek, IB | 1 |
| Artunay, O | 1 |
| Baidya, KP | 2 |
| Bandyopadhyay, R | 1 |
| Barba, I | 1 |
| Garcia-Ramírez, M | 1 |
| Hernández, C | 1 |
| Alonso, MA | 1 |
| Masmiquel, L | 1 |
| García-Dorado, D | 1 |
| Simó, R | 1 |
| Santiago, AR | 1 |
| Garrido, MJ | 1 |
| Cristóvão, AJ | 1 |
| Duarte, JM | 1 |
| Carvalho, RA | 1 |
| Ambrósio, AF | 1 |
| Choudhuri, S | 1 |
| Mandal, LK | 1 |
| Paine, SK | 1 |
| Sen, A | 1 |
| Dutta, D | 1 |
| Chowdhury, IH | 1 |
| Mukherjee, A | 1 |
| Saha, A | 1 |
| Bhadhuri, G | 1 |
| Nyengaard, JR | 1 |
| Ido, Y | 1 |
| Kilo, C | 1 |
| Williamson, JR | 1 |
| Amrite, AC | 1 |
| Ayalasomayajula, SP | 1 |
| Cheruvu, NP | 1 |
| Kompella, UB | 1 |
| Giri, A | 1 |
| Diederen, RM | 1 |
| Starnes, CA | 1 |
| Berkowitz, BA | 1 |
| Winkler, BS | 1 |
| Klemen, UM | 1 |
| McLellan, AC | 1 |
| Thornalley, PJ | 1 |
| Benn, J | 1 |
| Sonksen, PH | 1 |
| Suzuki, S | 1 |
| Hinokio, Y | 1 |
| Ohtomo, M | 1 |
| Hirai, M | 1 |
| Hirai, A | 1 |
| Chiba, M | 1 |
| Kasuga, S | 1 |
| Satoh, Y | 1 |
| Akai, H | 1 |
| Toyota, T | 1 |
| Miceli, MV | 1 |
| Newsome, DA | 1 |
| Gräfenstein, K | 1 |
| Duchna, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| A Novel Non-Invasive In Vivo Imaging System to Measure Retinal Metabolism[NCT00385333] | Phase 2 | 28 participants (Actual) | Interventional | 2006-09-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for lactic acid and Diabetic Retinopathy
| Article | Year |
|---|---|
The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation.
Topics: Adult; C-Peptide; Coenzymes; Deafness; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropat | 1998 |
16 other studies available for lactic acid and Diabetic Retinopathy
| Article | Year |
|---|---|
pH balance and lactic acid increase in the vitreous body of diabetes mellitus patients.
Topics: Aged; Blood Gas Analysis; Calcium; Carbon Dioxide; Cross-Sectional Studies; Diabetes Mellitus, Type | 2019 |
Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy.
Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 6; Diabetes Mellitus, Type 2; Diabetic Retinopat | 2020 |
Biochemical scenario behind initiation of diabetic retinopathy in type 2 diabetes mellitus.
Topics: Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retin | 2018 |
Evaluation of Biochemical Composition of Vitreous of Eyes of Diabetic Patients Using Proton Magnetic Resonance Spectroscopy.
Topics: Adult; Biomarkers; Creatine; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Fluorescein An | 2017 |
Alteration of timing of secretion of vascular endothelial growth factors is responsible for progression of diabetic retinopathy.
Topics: Anaerobic Threshold; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disea | 2008 |
Metabolic fingerprints of proliferative diabetic retinopathy: an 1H-NMR-based metabonomic approach using vitreous humor.
Topics: Adult; Ascorbic Acid; Carbon Isotopes; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Gala | 2010 |
Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.
Topics: Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glucose | 2010 |
Role of hyperglycemia-mediated erythrocyte redox state alteration in the development of diabetic retinopathy.
Topics: Blood Glucose; Blood Pressure; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Retinopa | 2013 |
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy.
Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito | 2004 |
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy.
Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito | 2004 |
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy.
Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito | 2004 |
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy.
Topics: Animals; Cell Hypoxia; Cornea; Diabetic Retinopathy; Glucose; Hyperglycemia; Lactic Acid; Male; Mito | 2004 |
Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage.
Topics: Animals; Blood-Retinal Barrier; Capillary Permeability; Celecoxib; Cell Culture Techniques; Cyclooxy | 2006 |
Relation between increased anaerobic glycolysis and visual acuity in long-standing type 2 diabetes mellitus without retinopathy.
Topics: Anaerobic Threshold; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Disease Progression; Follow-Up | 2006 |
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Cell Culture Techniques; Diabetes Mellitus, Exp | 2006 |
[Electron microscopic and chemical studies on the pathologically altered vitreous body].
Topics: Diabetic Retinopathy; Eye Proteins; Glycogen; Humans; In Vitro Techniques; Lactates; Lactic Acid; Ma | 1984 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Cultured retinal pigment epithelium cells from donors with type I diabetes show an altered insulin response.
Topics: Cell Division; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Endocytosis; Glucos | 1991 |
[Relation between glycohemoglobin, hypoxia parameters and diabetic microangiopathy].
Topics: 2,3-Diphosphoglycerate; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabetic Re | 1985 |