lactic acid has been researched along with Diabetic Nephropathies in 18 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 9.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 7.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 7.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| " However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis." | 5.22 | Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease. ( Rahman, F; Tuba, S, 2022) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 3.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "The reported incidence of metformin associated lactic acidosis (MALA) in type 2 diabetes mellitus (DM) is 3-9 cases per 100,000 patient-years." | 3.77 | Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements. ( Doorenbos, CJ; van Berlo-van de Laar, IR; Vermeij, CG, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Grochowalska, K | 1 |
| Pikul, P | 1 |
| Piwkowska, A | 1 |
| Rahman, F | 1 |
| Tuba, S | 1 |
| Azushima, K | 1 |
| Kovalik, JP | 1 |
| Yamaji, T | 1 |
| Ching, J | 1 |
| Chng, TW | 1 |
| Guo, J | 1 |
| Liu, JJ | 1 |
| Nguyen, M | 1 |
| Sakban, RB | 1 |
| George, SE | 1 |
| Tan, PH | 1 |
| Lim, SC | 2 |
| Gurley, SB | 1 |
| Coffman, TM | 1 |
| Gosmanova, EO | 1 |
| Shahzad, SR | 1 |
| Sumida, K | 1 |
| Kovesdy, CP | 1 |
| Gosmanov, AR | 1 |
| Nørlinger, TS | 1 |
| Nielsen, PM | 1 |
| Qi, H | 1 |
| Mikkelsen, E | 1 |
| Hansen, K | 1 |
| Schmidt, NH | 1 |
| Pedersen, M | 2 |
| Agger, P | 1 |
| Palm, F | 2 |
| Laustsen, C | 2 |
| Connelly, PJ | 1 |
| Lonergan, M | 1 |
| Soto-Pedre, E | 1 |
| Donnelly, L | 1 |
| Zhou, K | 1 |
| Pearson, ER | 1 |
| Lycke, S | 1 |
| Østergaard, JA | 1 |
| Bibby, BM | 1 |
| Nørregaard, R | 1 |
| Flyvbjerg, A | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Varol, U | 1 |
| Varol, Y | 1 |
| Yaprak, M | 1 |
| Uzum, A | 1 |
| Cirit, M | 1 |
| Chou, CK | 1 |
| Lee, YT | 1 |
| Chen, SM | 1 |
| Hsieh, CW | 1 |
| Huang, TC | 1 |
| Li, YC | 1 |
| Lee, JA | 1 |
| Kurz, B | 1 |
| Müller, GA | 1 |
| van Berlo-van de Laar, IR | 1 |
| Vermeij, CG | 1 |
| Doorenbos, CJ | 1 |
| Lim, VC | 1 |
| Sum, CF | 1 |
| Chan, ES | 1 |
| Yeoh, LY | 1 |
| Lee, YM | 1 |
| Mäkinen, VP | 1 |
| Soininen, P | 1 |
| Forsblom, C | 1 |
| Parkkonen, M | 1 |
| Ingman, P | 1 |
| Kaski, K | 1 |
| Groop, PH | 1 |
| Ala-Korpela, M | 1 |
| Bazzato, G | 1 |
| Coli, U | 1 |
| Landini, S | 1 |
| Fracasso, A | 1 |
| Morachiello, P | 1 |
| Righetto, F | 1 |
| Scanferla, F | 1 |
| Onesti, G | 1 |
| McLellan, AC | 1 |
| Thornalley, PJ | 1 |
| Benn, J | 1 |
| Sonksen, PH | 1 |
| Suzuki, S | 1 |
| Hinokio, Y | 1 |
| Ohtomo, M | 1 |
| Hirai, M | 1 |
| Hirai, A | 1 |
| Chiba, M | 1 |
| Kasuga, S | 1 |
| Satoh, Y | 1 |
| Akai, H | 1 |
| Toyota, T | 1 |
| Lindgren, L | 1 |
| Tikkanen, I | 1 |
| Reissell, E | 1 |
| Kirvelä, M | 1 |
| Orko, R | 1 |
| Salmela, K | 1 |
| Ahonen, J | 1 |
| Adrogué, HJ | 1 |
3 reviews available for lactic acid and Diabetic Nephropathies
| Article | Year |
|---|---|
Insights into the regulation of podocyte and glomerular function by lactate and its metabolic sensor G-protein-coupled receptor 81.
Topics: Diabetic Nephropathies; Humans; Lactic Acid; Podocytes; Proteinuria; Receptors, G-Protein-Coupled | 2022 |
Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease.
Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Hypoglycemic Agents; La | 2022 |
Glucose homeostasis and the kidney.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Glucose; Glycogen; | 1992 |
1 trial available for lactic acid and Diabetic Nephropathies
| Article | Year |
|---|---|
The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation.
Topics: Adult; C-Peptide; Coenzymes; Deafness; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropat | 1998 |
14 other studies available for lactic acid and Diabetic Nephropathies
| Article | Year |
|---|---|
Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Di | 2023 |
Metformin is associated with increase in lactate level in elderly patients with type 2 diabetes and CKD stage 3: A case-control study.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neph | 2020 |
Hyperbaric oxygen therapy reduces renal lactate production.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Hyperbaric Oxygenation; Ki | 2017 |
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Melli | 2017 |
High altitude may alter oxygen availability and renal metabolism in diabetics as measured by hyperpolarized [1-(13)C]pyruvate magnetic resonance imaging.
Topics: Alanine; Altitude; Altitude Sickness; Animals; Atmospheric Pressure; Bicarbonates; Blood Glucose; Di | 2014 |
Association between hyperlactatemia and occult cardiac failure in diabetic patients on maintenance hemodialysis.
Topics: Aged; Bicarbonates; Blood Gas Analysis; Diabetic Nephropathies; Echocardiography; Female; Heart Fail | 2014 |
Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria.
Topics: Adult; Aged; Albuminuria; Biomarkers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Hum | 2015 |
[Acute abdominal pain in a 70-year-old patient on hemodialysis].
Topics: Abdominal Pain; Aged; Colectomy; Colon; Diabetic Nephropathies; Diagnosis, Differential; Foreign Bod | 2009 |
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.
Topics: Acidosis, Lactic; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Early | 2011 |
Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.
Topics: Acidosis, Lactic; Asia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; | 2007 |
1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death.
Topics: Acetates; Adult; Albuminuria; Antihypertensive Agents; Apolipoproteins B; Biomarkers; Cholesterol; C | 2008 |
Xylitol as osmotic agent in CAPD: an alternative to glucose for uremic diabetic patients?
Topics: Adult; Diabetic Nephropathies; Female; Humans; Insulin; Lactates; Lactic Acid; Lipids; Male; Middle | 1982 |
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications.
Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi | 1994 |
Alpha-human-ANP response to preanesthetic volume expansion and subsequent renal transplantation in diabetic and nondiabetic uremic patients.
Topics: Adult; Atrial Natriuretic Factor; Blood Volume; Diabetic Nephropathies; Female; Humans; Kidney Trans | 1992 |