lactic acid and Diabetes Mellitus studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

Excerpt	Relevance	Reference
"Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward."	7.85	Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017)
"Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear."	7.78	Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012)
" Lactic acidosis occurs in association with acute illness particularly in diabetes."	7.77	Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011)
" Glucose and lactic acid in vitreous humor and blood levels of acetone were found to be valuable indicators of antemortem hyperglycemia in diabetics."	7.69	The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. ( Jobin, F; Péclet, C; Picotte, P, 1994)
"The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years."	7.69	Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. ( Dailey, G; Gerich, JE; Nurjhan, N; Perriello, G; Stumvoll, M, 1995)
"Diabetes mellitus is a chronic metabolic illness responsible for a great number of deaths."	5.31	Glucose and lactate in vitreous humor compared with the determination of fructosamine for the postmortem diagnosis of diabetes mellitus. ( Conejero, J; García-Víllora, A; Luna, A; Maria Abenza, J; Martínez, P; Osuna, E; Pérez-Cárceles, M, 2001)
"The aim was to justify less restrictive use of metformin in stable chronic renal failure, because a literature review reveals metformin is associated with a significantly lower incidence of cardiovascular events and mortality compared with other hypoglycaemic agents, and metformin-associated lactic acidosis is rare and causation uncertain."	4.90	A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. ( Adam, WR; O'Brien, RC, 2014)
"Chronic metformin treatment mildly increases lactate level, but does not induce hyperlactatemia or lactic acidosis in acute illness on the first day of admission to an internal medicine ward."	3.85	Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. ( Doenyas-Barak, K; Golik, A; Koren, R; Koren, S; Zilberman-Itskovich, S, 2017)
"Lactic acidosis is a fatal adverse effect of metformin, but the risk factor remains unclear."	3.78	Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. ( Fujimoto, S; Hosokawa, M; Inagaki, N; Inui, K; Katsura, T; Masuda, S; Osawa, R; Toyama, K; Yonezawa, A, 2012)
" Lactic acidosis occurs in association with acute illness particularly in diabetes."	3.77	Diabetes, metformin and lactic acidosis. ( Harvey, JN; Scale, T, 2011)
"Metformin (MTF) is one of the most common oral agents used to treat diabetes mellitus."	3.77	Metformin intoxication requiring dialysis. ( Concepcion, L; Nguyen, HL, 2011)
"Maternally inherited diabetes and deafness (MIDD) and myoencephalopathy, lactic acidosis, stroke-like episodes (MELAS) syndromes are characterized by the same A3243G mutation of mitochondrial DNA (mtDNA)."	3.75	Brain anomalies in maternally inherited diabetes and deafness syndrome. ( Cozzone, PJ; Felician, O; Fromont, I; Lebail, B; Lefur, Y; Mancini, J; Nicoli, F; Paquis-Flucklinger, V; Valéro, R; Vialettes, B, 2009)
" This association is suggestive of the MIDD syndrome and the demonstration of metabolic abnormalities (raised serum lactic acid, abnormal lactate/pyruvate ratio) was compatible with a mitochondrial disease."	3.74	[Dilated cardiomyopathy, diabetes and deafness related to a mutation of mitochondrial DNA]. ( Charbonnier, B; Ferreira-Maldent, N; Guilmot, JL; Maillot, F; Quilliet, L, 2007)
" Glucose and lactic acid in vitreous humor and blood levels of acetone were found to be valuable indicators of antemortem hyperglycemia in diabetics."	3.69	The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. ( Jobin, F; Péclet, C; Picotte, P, 1994)
" Hyperglycemia-induced increases of plasma C-peptide concentrations were comparable to those in controls (p = NS)."	3.69	Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. ( Matthews, D; Petrides, AS; Schulze-Berge, D; Strohmeyer, G; Vogt, C, 1994)
"The metabolic effects and mechanism of action of metformin are still poorly understood, despite the fact that it has been used to treat patients with non-insulin-dependent diabetes mellitus (NIDDM) for more than 30 years."	3.69	Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. ( Dailey, G; Gerich, JE; Nurjhan, N; Perriello, G; Stumvoll, M, 1995)
"The effect of metformin on glucose metabolism was examined in eight obese (percent ideal body weight, 151 +/- 9%) and six lean (percent ideal body weight, 104 +/- 4%) noninsulin-dependent diabetic (NIDD) subjects before and after 3 months of metformin treatment (2."	3.68	Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. ( Barzilai, N; DeFronzo, RA; Simonson, DC, 1991)
"By central venous catheterization, 6 control persons, 7 patients with liver cirrhosis and 6 patients with diabetes mellitus were infused for 48 h with a 20% (w/v) mixture of glucose/xylitol (1:1)."	3.66	[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VI. Infusions of a glucose/xylitol mixture (1:1 ratio) over a 48-hour period]. ( Egberts, EH; Horbach, L; Malchow, H; Müller, PH; Prestele, H; Rittershofer, H; Schmülling, R, 1982)
"Persons with type II diabetes mellitus (DM), even without cardiovascular complications have a decreased maximal oxygen consumption (VO2 max) and submaximal oxygen consumption (VO2) during graded exercise compared with healthy controls."	2.69	Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. ( Bauer, TA; Brandenburg, SL; Eckel, RH; Hiatt, WR; Regensteiner, JG; Reusch, JE; Sippel, JM; Smith, S; Vogelsong, AM; Wolfel, EE, 1998)
"Defective GS activity in obese NIDDM patients is not secondary to hyperglycemia."	2.69	Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin. ( Beck-Nielsen, H; Damsbo, P; Hermann, LS; Hother-Nielsen, O; Vaag, A, 1998)
"Both cancer and diabetes have been associated with abnormal lactate metabolism and high level of lactate production is the key biological property of these diseases."	2.53	Lactate, a Neglected Factor for Diabetes and Cancer Interaction. ( Atefi, M; Dong, Y; Elshimali, Y; Liu, Y; Vadgama, JV; Wu, Y, 2016)
"Glycogen metabolism has important implications for the functioning of the brain, especially the cooperation between astrocytes and neurons."	2.52	Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. ( Baranowska-Bosiacka, I; Chlubek, D; Falkowska, A; Goschorska, M; Gutowska, I; Nowacki, P, 2015)
"Post mortem diagnosis of glucose metabolism disorders can be difficult and vague because of the lack of characteristic morphological findings."	2.47	Disorders of glucose metabolism-post mortem analyses in forensic cases: part I. ( Hess, C; Madea, B; Musshoff, F, 2011)
"Hyperlactatemia was associated with in-hospital mortality (Odds Ratio [OR] 1."	1.91	Association between elevated lactate and clinical outcomes in adults with diabetic ketoacidosis. ( Doola, R; Kumar, A; Laupland, KB; Ramanan, M; Shaikh, A; Tabah, A; Zahumensky, A, 2023)
"Sepsis is a leading cause of morbidity and mortality in hospitalized patients."	1.72	Machine learning models to predict in-hospital mortality in septic patients with diabetes. ( Dai, Z; Huang, D; Lei, J; Li, N; Liu, H; Qi, J; Sun, C; Zhou, K, 2022)
"We reviewed episodes of diabetic ketoacidosis from 79 diabetes patients (one episode per patient)."	1.72	Hyperlactatemia in diabetic ketoacidosis. ( Brooks, GA; Lazar, AA; Masharani, U; Strycker, LA; Wu, K, 2022)
"Respiratory failure was the most frequently observed complication (106 [67."	1.62	Identification of risk factors for in-hospital death of COVID - 19 pneumonia -- lessions from the early outbreak. ( Wang, Z, 2021)
"Conditions include Alzheimer's disease, atherosclerosis, diabetes mellitus, obesity, cancer, autoimmunity and psychosis, amongst others."	1.48	Optimise the microbial flora with milk and yoghurt to prevent disease. ( Morris, JA, 2018)
" Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice."	1.46	Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice. ( Abe, K; Egashira, K; Fukuda, K; Kamei, A; Kinjo, A; Kondo, T; Kozuka, C; Masuzaki, H; Morinaga, H; Nakano, K; Shimizu-Okabe, C; Takayama, C; Yasuoka, A, 2017)
"Using the adverse outcomes of cardiac arrest, ICU mortality, and ICU readmissions, a retrospective case-control study was performed using three demographic items (age, diabetes, and morbid obesity) and 24 EWD measured items, including vital signs, laboratory values, ventilator information, and other clinical information, to validate the EWD."	1.46	Validation of the Intensive Care Unit Early Warning Dashboard: Quality Improvement Utilizing a Retrospective Case-Control Evaluation. ( Davis, KL; Kavanaugh, MJ; Park, PJ; So, JD, 2017)
"Diabetes and cardiovascular diseases are major causes of morbidity and mortality worldwide, and are associated with changes in the human gut microbiota."	1.43	Comparative Fingerprinting of the Human Microbiota in Diabetes and Cardiovascular Disease. ( Pelinescu, D; Sarbu, I; Vamanu, E, 2016)
"Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal."	1.39	Assessment of Traub formula and ketone bodies in cause of death investigations. ( Keltanen, T; Lindroos, K; Palo, JU; Partanen, T; Sajantila, A; Valonen, T, 2013)
"Melatonin-induced increase in glucose and lactate synthesis was accompanied by an enhancement of alanine and glycerol consumption."	1.33	Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules. ( Bryla, J; Derlacz, RA; Jagielski, AK; Napierala, M; Poplawski, P, 2005)
"Mitochondrial disorders are generally not associated with a clear phenotype-genotype relationship, which complicates the understanding of the disease and genetic counseling."	1.33	Muscle phenotype and mutation load in 51 persons with the 3243A>G mitochondrial DNA mutation. ( Frederiksen, AL; Jeppesen, TD; Olsen, DB; Schwartz, M; Vissing, J; Wibrand, F, 2006)
"Glycerol release (GR) was used to assess the lipolytic rate and was highest in LW in the abdominal area [0 h: LW, 1."	1.31	Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa. ( Boyd, IH; Crowther, NJ; Gray, IP; Joffe, BI; Lönnroth, PN; Schlaphoff, GP; van der Merwe, MT, 2001)
"Diabetes mellitus is a chronic metabolic illness responsible for a great number of deaths."	1.31	Glucose and lactate in vitreous humor compared with the determination of fructosamine for the postmortem diagnosis of diabetes mellitus. ( Conejero, J; García-Víllora, A; Luna, A; Maria Abenza, J; Martínez, P; Osuna, E; Pérez-Cárceles, M, 2001)
"We studied seven obese subjects with type 2 diabetes and seven lean and seven obese control subjects (fasting plasma glucose levels, 7."	1.30	Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. ( Giacca, A; Groenewoud, Y; McClean, P; Tsui, E; Zinman, B, 1998)
"Thus, in NIDDM patients, fasting corrects the defect in glycogen storage without modifying the action of insulin on glucose uptake and improves beta-cell responsiveness, the latter two effects being opposite to those observed in nondiabetic subjects."	1.29	Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. ( Balasse, EO; Féry, F, 1994)
"When thiamine was added to cells kept under high glucose conditions, the number of surviving cells was significantly increased and the reduced cell proliferation appeared to be corrected."	1.29	Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions. ( Beltramo, E; Bena, E; La Selva, M; Molinatti, GM; Molinatti, PA; Pagnozzi, F; Porta, M, 1996)

Research

Studies (134)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Concentration of Metformin in Adipose Tissue

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (32.09)	18.7374
1990's	20 (14.93)	18.2507
2000's	23 (17.16)	29.6817
2010's	38 (28.36)	24.3611
2020's	10 (7.46)	2.80

Authors	Studies
Masharani, U	1
Strycker, LA	1
Lazar, AA	1
Wu, K	1
Brooks, GA	1
Watha, K	1
Davenport, A	1
Tangvoraphonkchai, K	1
Qi, J	3
Lei, J	3
Li, N	3
Huang, D	3
Liu, H	3
Zhou, K	3
Dai, Z	3
Sun, C	3
Yu, H	1
Li, Y	1
Pan, Y	1
Wang, H	1
Wang, W	1
Ren, X	1
Yuan, H	1
Lv, Z	1
Zuo, Y	1
Liu, Z	1
Lin, W	1
Yao, Q	1
Kumar, A	1
Doola, R	1
Zahumensky, A	1
Shaikh, A	1
Tabah, A	1
Laupland, KB	1
Ramanan, M	1
Fitzgerald, O	1
Perez-Concha, O	1
Gallego-Luxan, B	1
Rudd, L	1
Jorm, L	1
Ogura, A	1
Tsurumi, A	1
Que, YA	1
Almpani, M	1
Zheng, H	1
Tompkins, RG	1
Ryan, CM	1
Rahme, LG	1
Luo, E	1
Wang, D	1
Yan, G	1
Qiao, Y	1
Zhu, B	1
Liu, B	1
Hou, J	1
Tang, C	1
Wang, K	1
Qiu, Z	1
Liu, J	1
Fan, T	1
Liu, C	1
Tian, P	1
Wang, Y	2
Ni, Z	1
Zhang, S	1
Luo, J	1
Liu, D	1
Li, W	1
Wang, Z	2
Eseberri, I	1
Laurens, C	1
Miranda, J	1
Louche, K	1
Lasa, A	1
Moro, C	1
Portillo, MP	1
Koren, S	1
Zilberman-Itskovich, S	1
Koren, R	1
Doenyas-Barak, K	1
Golik, A	1
Jeong, HS	1
Lee, TH	1
Bang, CH	1
Kim, JH	1
Hong, SJ	1
Morris, JA	1
Hankir, MK	1
Klingenspor, M	1
Zhu, Y	1
Ma, WQ	1
Han, XQ	1
Wang, X	2
Liu, NF	1
González-Lao, E	1
Corte, Z	1
Simón, M	1
Ricós, C	1
Coskun, A	1
Braga, F	1
Aarsand, AK	1
Carobene, A	1
Bartlett, WA	1
Boned, B	1
Asland, B	1
Díaz-Garzón, J	1
Marqués-García, F	1
Minchinela, J	1
Perich, C	1
Fernández-Calle, P	1
Roraas, T	1
Fernández-Fernández, P	1
Jonker, N	1
Sandberg, S	1
Lee, BH	1
Hsu, WH	1
Hsu, YW	1
Pan, TM	1
Seaquist, ER	1
Öz, G	1
Matsushita, K	1
Williams, EK	1
Mongraw-Chaffin, ML	1
Coresh, J	1
Schmidt, MI	1
Brancati, FL	1
Hoogeveen, RC	1
Ballantyne, CM	1
Young, JH	1
Keltanen, T	1
Sajantila, A	1
Palo, JU	1
Partanen, T	1
Valonen, T	1
Lindroos, K	1
Hosseininasab, S	1
Pashaei-Asl, R	1
Khandaghi, AA	1
Nasrabadi, HT	1
Nejati-Koshki, K	1
Akbarzadeh, A	1
Joo, SW	1
Hanifehpour, Y	1
Davaran, S	1
Adam, WR	1
O'Brien, RC	1
Adeva-Andany, M	1
López-Ojén, M	1
Funcasta-Calderón, R	1
Ameneiros-Rodríguez, E	1
Donapetry-García, C	1
Vila-Altesor, M	1
Rodríguez-Seijas, J	1
Dias, TR	1
Alves, MG	1
Silva, BM	1
Oliveira, PF	1
Takayama, T	2
Kuwabara, T	1
Maeda, T	2
Noge, I	3
Kitagawa, Y	3
Inoue, K	2
Todoroki, K	3
Min, JZ	3
Toyo'oka, T	3
Sng, MK	1
Foo, S	1
Chong, HC	1
Lee, WL	1
Tang, MB	1
Ng, KW	1
Luo, B	1
Choong, C	1
Wong, MT	1
Tong, BM	1
Chiba, S	1
Loo, SC	1
Zhu, P	1
Tan, NS	1
Falkowska, A	1
Gutowska, I	1
Goschorska, M	1
Nowacki, P	1
Chlubek, D	1
Baranowska-Bosiacka, I	1
Numako, M	1
Mizuno, H	1
Carati, D	1
Zizza, A	1
Guido, M	1
De Donno, A	1
Stefanizzi, R	1
Serra, R	1
Romano, I	1
Ouedraogo, C	1
Megha, M	1
Tinelli, A	1
Miyamoto, S	1
Hsu, CC	1
Hamm, G	1
Darshi, M	1
Diamond-Stanic, M	1
Declèves, AE	1
Slater, L	1
Pennathur, S	1
Stauber, J	1
Dorrestein, PC	1
Sharma, K	1
Kavanaugh, MJ	1
So, JD	1
Park, PJ	1
Davis, KL	1
Vamanu, E	1
Pelinescu, D	1
Sarbu, I	1
Wu, Y	1
Dong, Y	1
Atefi, M	1
Liu, Y	1
Elshimali, Y	1
Vadgama, JV	1
van den Nouland, DP	1
Brouwers, MC	1
Stassen, PM	1
Kozuka, C	1
Shimizu-Okabe, C	1
Takayama, C	1
Nakano, K	1
Morinaga, H	1
Kinjo, A	1
Fukuda, K	1
Kamei, A	1
Yasuoka, A	1
Kondo, T	1
Abe, K	1
Egashira, K	1
Masuzaki, H	1
Sola-Penna, M	1
Talasniemi, JP	1
Pennanen, S	1
Savolainen, H	1
Niskanen, L	1
Liesivuori, J	1
Basarkar, A	1
Singh, J	1
Fromont, I	1
Nicoli, F	1
Valéro, R	1
Felician, O	1
Lebail, B	1
Lefur, Y	1
Mancini, J	1
Paquis-Flucklinger, V	1
Cozzone, PJ	1
Vialettes, B	1
Titov, VN	1
Dmitriev, LF	1
Krylin, VA	1
Dmitriev, VA	1
Hess, C	2
Musshoff, F	2
Madea, B	2
ROOT, HF	1
STOTZ, E	1
CARPENTER, TM	1
Scale, T	1
Harvey, JN	1
Kim, H	1
Park, H	1
Lee, J	1
Kim, TH	1
Lee, ES	1
Oh, KT	1
Lee, KC	1
Youn, YS	1
Cózar-Bernal, MJ	1
Holgado, MA	1
Arias, JL	1
Muñoz-Rubio, I	1
Martín-Banderas, L	1
Alvarez-Fuentes, J	1
Fernández-Arévalo, M	1
Jelen, S	1
Wacker, S	1
Aponte-Santamaría, C	1
Skott, M	1
Rojek, A	1
Johanson, U	1
Kjellbom, P	1
Nielsen, S	1
de Groot, BL	1
Rützler, M	1
Nguyen, HL	1
Concepcion, L	1
Toyama, K	1
Yonezawa, A	1
Masuda, S	1
Osawa, R	1
Hosokawa, M	1
Fujimoto, S	2
Inagaki, N	2
Inui, K	1
Katsura, T	1
Shimizu, I	1
Ishikawa, E	1
Fukuda, T	1
Okazaki, S	1
Stratmann, B	1
Quester, W	1
Tschoepe, D	1
Tsutsui, H	1
Mochizuki, T	1
Sasaki, M	1
Sato, Y	1
Nishi, Y	1
Mukai, E	1
Yamano, G	1
Sato, H	1
Tahara, Y	1
Ogura, K	1
Nagashima, K	1
Noda, M	1
Yamashita, S	1
Takahashi, N	1
Eto, K	1
Shen, LM	1
Izumi, K	1
Daniel, S	1
Tsubamoto, Y	1
Nemoto, T	1
Iino, M	1
Kasai, H	1
Sharp, GW	1
Kadowaki, T	1
Totani, M	1
Hasegawa, H	1
Fukushima, T	1
Lee, JA	1
Tsukamoto, K	1
Moriya, K	1
Ono, Y	1
Imai, K	1
Marshall, J	1
Jennings, P	1
Scott, A	1
Fluck, RJ	1
McIntyre, CW	1
MONTENERO, P	1
BOLDRINI, R	1
DUMM, ME	1
MILLER, M	1
CRAIG, JW	1
MACKENZIE, MS	1
DRUCKER, WR	1
CAMMARN, MW	1
WOODWARD, H	1
CATTANEO, R	2
PELOCCHINO, AM	2
PRINOTTI, C	2
BOERO, P	1
SAN LORENZO, G	1
FACCHINI, G	1
DI SALVO, C	3
FERSINI, C	1
RIPA, R	1
SBRIGHI, V	1
ANDERSON, J	1
MAZZA, R	1
DE MEUTTER, RC	1
SHREEVE, WW	3
EWY, GA	1
PABICO, RC	1
MAHER, JF	1
MINTZ, DH	1
GHOSE, A	1
SHIGETS, Y	1
SCHWARTZ, IL	1
DEMEUTTER, RC	1
MENGIS, CL	1
DEBRY, G	1
LAURENT, J	1
MILLER, HI	1
ISSEKUTZ, B	1
RODAHL, K	1
PAUL, P	1
POLOSA, P	1
Lee, PY	2
Li, Z	1
Huang, L	2
FELTS, JM	1
CHAIKOFF, IL	1
OSBORN, MJ	1
Leegsma-Vogt, G	1
Rhemrev-Boom, MM	1
Tiessen, RG	1
Venema, K	1
Korf, J	1
Derlacz, RA	1
Poplawski, P	1
Napierala, M	1
Jagielski, AK	1
Bryla, J	1
Smith, CE	1
Styn, NR	1
Kalhan, S	1
Pinchak, AC	1
Gill, IS	1
Kramer, RP	1
Sidhu, T	1
Shiraishi, K	1
Motegi, S	1
Nagaoka, R	1
Ogasawara, F	1
Saito, T	1
Watanabe, M	1
Matsuzaki, S	1
Jeppesen, TD	1
Schwartz, M	1
Frederiksen, AL	1
Wibrand, F	1
Olsen, DB	1
Vissing, J	1
Cobain, E	1
Huard, J	1
Ferreira-Maldent, N	1
Maillot, F	1
Quilliet, L	1
Guilmot, JL	1
Charbonnier, B	1
Bocharnikova, NV	1
Pagano, G	1
Tagliaferro, V	1
Carta, Q	1
Caselle, MT	1
Bozzo, C	1
Vitelli, F	1
Trovati, M	1
Cocuzza, E	1
Hanson, RL	1
Ho, RS	1
Wiseberg, JJ	1
Simpson, R	1
Younathan, ES	1
Blair, JB	1
Goodkin, DA	1
Krishna, GG	1
Narins, RG	1
Nosadini, R	1
Noy, GA	1
Nattrass, M	2
Alberti, KG	3
Johnston, DG	1
Home, PD	1
Orskov, H	1
Martin, MJ	1
Robbins, DC	1
Bergenstal, R	1
LaGrange, B	1
Rubenstein, AH	1
Möricke, R	1
Niederstrasser, A	1
Caruso, M	1
Zinman, B	3
Marliss, EB	2
Hanna, AK	1
Minuk, HL	1
Vranic, M	2
Passariello, N	1
Fici, F	1
Giugliano, D	1
Ceriello, A	1
Dello Russo, P	1
Sgambato, S	1
Sheppard, MC	1
Burrin, J	1
Karamanos, BG	1
Christacopoulos, PD	1
Andriotis, AT	1
Tountas, CD	1
Komninos, ZD	1
Egberts, EH	1
Rittershofer, H	1
Müller, PH	1
Schmülling, R	1
Prestele, H	1
Horbach, L	1
Malchow, H	1
Lager, I	1
Smith, U	1
Dall'Aglio, E	1
Zavaroni, I	1
Alpi, O	1
Coscelli, C	1
Butturini, U	1
Hollmann, W	1
Dufaux, B	1
Rost, R	1
Burrin, JM	1
Worth, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Glycemic Control Assessed by Continuous Glucose Monitoring in Hemodialyzed Patients With Diabetes Mellitus Treated Via the Basal-Bolus Detemir-Aspart Insulin Regimen: A Pilot Study[NCT01828970]	Phase 4	38 participants (Actual)	Interventional	2010-01-31	Completed
Metformin Pharmacology in Human Cancers[NCT03477162]	Early Phase 1	18 participants (Actual)	Interventional	2018-05-15	Terminated (stopped due to Enrollment was closed as efforts had become more challenging, and the lab indicated that they were able to obtain their primary objective with the number that had already been enrolled.)
Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224]	Phase 2/Phase 3	90 participants (Anticipated)	Interventional	2018-07-07	Recruiting
Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.[NCT01589445]	Phase 4	77 participants (Actual)	Interventional	2008-11-30	Completed
Gastric Tolerability and Pharmacokinetics of an Extended Release Metformin and an Immediate Release Metformin[NCT00941239]	Phase 1	24 participants (Actual)	Interventional	2007-01-31	Completed
Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.[NCT04626089]	Phase 2	0 participants (Actual)	Interventional	2021-02-28	Withdrawn (stopped due to Administrative decision of the company)
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (T1D)--Insulin Clamp Ancillary Study for Assessment of Insulin Resistance[NCT02045290]	Phase 3	37 participants (Actual)	Interventional	2014-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

To determine the concentration of metformin in adipose tissue. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Plasma.

Intervention	ng/g (Median)
Metformin	70

To determine the concentration of metformin in plasma. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Tumor-adjacent Normal Tissue

Intervention	ng/mL (Median)
Metformin	450

To determine the concentration of metformin in tumor-adjacent normal tissue. (NCT03477162)
Timeframe: Within 7 days from surgery

Concentration of Metformin in Whole Blood.

Intervention	ng/g (Median)
Metformin	749

To determine the concentration of metformin in whole blood. (NCT03477162)
Timeframe: Within 7 days from surgery

Lung Tumor Tissue Concentration of Metformin

Intervention	ng/mL (Median)
Metformin	514

To determine the intra-tumor concentrations of metformin, with a standard deviation ≤25% of the mean, in patients with solid tumors of thoracic origin administered metformin extended release. (NCT03477162)
Timeframe: Within 7 days from surgery

Comparison of Changes in Fasting Serum Glucose (FSG)With Pioglitazone and Metformin

Intervention	ng/g (Median)
Metformin	1290

Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin. (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Fasting Serum Insulin (FSI)With Pioglitazone and Metformin

Intervention	mmol/l (Mean)
	Baseline FSG	3rd Month FSG
Metformin ( 002 Group)	6.2	6.5
Pioglitazone (001 Group)	6.9	5.4

Comparison of Changes in Glycosylated Hemoglobin (HbA1c)With Pioglitazone and Metformin

Intervention	μU/ml (Mean)
	Baseline FSI	3rd month FSI
Metformin ( 002 Group)	13.0	13.9
Pioglitazone (001 Group)	16.2	12.3

Comparison of Changes in HOMA Percent B and HOMA Percent S With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HbA1c	3rd month HbA1c
Metformin ( 002 Group)	7.8	7.0
Pioglitazone (001 Group)	7.3	6.7

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostatic Model Assessment of Beta cell function(HOMA percent B) Analysis 2: Homeostatic Model Assessment of Insulin Sensitivity (Homa percent S)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Insulin Levels (HOMA IR,QUICKI) With Pioglitazone and Metformin

Intervention	percentage (Mean)
	Baseline HOMA percent beta cells function	3rd month HOMA percent beta cells function	Baseline HOMA percent sensitivity	3rd month HOMA percent sensitivity
Metformin ( 002 Group)	109.3	116.0	76.2	67.2
Pioglitazone (001 Group)	118.9	132.3	51.1	69.3

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1: Homeostasis Model Assessment Insulin Resistance(HOMA IR) Analysis 2: Quantitative Insulin sensitivity Check Index(QUICKI)" (NCT01589445)
Timeframe: 3 months for each drug

Comparison of Changes in Lipid Profiles With Pioglitazone and Metformin

Intervention	Score on a scale ( SI unit) (Mean)
	Baseline QUICKI	3rd month QUICKI	Baseline HOMA IR	3rd month HOMA IR
Metformin ( 002 Group)	0.57	0.54	3.7	4.3
Pioglitazone (001 Group)	0.52	0.59	5.1	2.9

"Response rate was defined by ≥10% decrease of FSG or/and ≥1% decrease of HbA1c from the baseline values after 3 months treatment.48 responded to pioglitazone and 32 responded to metformin.~Analysis 1:Total Cholesterol(TC) Analysis 2:Triglyceride(TG) Analysis 3:High Density Lipoprotein(HDL) Analysis 4:Low Density Lipoprotein(LDL)" (NCT01589445)
Timeframe: 3 months for each drug

Intervention	mg/dl (Mean)
	Baseline TC	3rd month TC	Baseline TG	3rd month TG	Baseline HDL	3rd month HDL	Baseline LDL	3rd month LDL
Metformin (002 Group)	193.0	177.0	166.0	175.0	34.4	34.7	125.6	112.0
Pioglitazone (001 Group)	182.0	178	183	195	33	33.2	112.8	105.5

Article	Year
Brown adipocyte glucose metabolism: a heated subject. EMBO reports, 2018, Volume: 19, Issue:9 Topics: Adipose Tissue, Brown; Animals; Diabetes Mellitus; Drug Discovery; Glucose; Glycolysis; Humans; Lact	2018
Systematic review of the biological variation data for diabetes related analytes. Clinica chimica acta; international journal of clinical chemistry, 2019, Volume: 488 Topics: Adiponectin; Blood Glucose; C-Peptide; Diabetes Mellitus; Fructosamine; Glycated Hemoglobin; Humans;	2019
A justification for less restrictive guidelines on the use of metformin in stable chronic renal failure. Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:9 Topics: Acidosis, Lactic; Diabetes Mellitus; Drug Administration Schedule; Drug Overdose; Glomerular Filtrat	2014
Comprehensive review on lactate metabolism in human health. Mitochondrion, 2014, Volume: 17 Topics: Alanine; Carbon Dioxide; Diabetes Mellitus; Glucose; Humans; Lactic Acid; Metabolic Networks and Pat	2014
Sperm glucose transport and metabolism in diabetic individuals. Molecular and cellular endocrinology, 2014, Volume: 396, Issue:1-2 Topics: Biological Transport; Citric Acid Cycle; Diabetes Mellitus; Fertility; Gene Expression Regulation; G	2014
Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. International journal of molecular sciences, 2015, Oct-29, Volume: 16, Issue:11 Topics: Animals; Astrocytes; Biological Transport; Brain; Cerebrovascular Circulation; Citric Acid Cycle; Di	2015
Lactate, a Neglected Factor for Diabetes and Cancer Interaction. Mediators of inflammation, 2016, Volume: 2016 Topics: Animals; Cell Line, Tumor; Diabetes Complications; Diabetes Mellitus; Disease Progression; Humans; H	2016
Metabolic regulation by lactate. IUBMB life, 2008, Volume: 60, Issue:9 Topics: Blood Glucose; Diabetes Mellitus; Energy Metabolism; Exercise; Homeostasis; Humans; Insulin; Lactic	2008
Disorders of glucose metabolism-post mortem analyses in forensic cases: part I. International journal of legal medicine, 2011, Volume: 125, Issue:2 Topics: Blood Proteins; Diabetes Mellitus; Diabetic Ketoacidosis; Forensic Pathology; Fructosamine; Glucose;	2011
[Lactate . pyruvate]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8 Topics: Acidosis, Lactic; Biomarkers; Diabetes Mellitus; Humans; Lactic Acid; Neoplasms; Pyruvic Acid	2002
The potential of biosensor technology in clinical monitoring and experimental research. Bio-medical materials and engineering, 2004, Volume: 14, Issue:4 Topics: Biosensing Techniques; Biotechnology; Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus; Equ	2004

Article	Year
Safety, efficacy, and tolerability of differential treatment to prevent and treat vaginal dryness and vulvovaginitis in diabetic women. Clinical and experimental obstetrics & gynecology, 2016, Volume: 43, Issue:2 Topics: Administration, Intravaginal; Adult; Candidiasis, Vulvovaginal; Diabetes Complications; Diabetes Mel	2016
Intraoperative glucose control in diabetic and nondiabetic patients during cardiac surgery. Journal of cardiothoracic and vascular anesthesia, 2005, Volume: 19, Issue:2 Topics: Aged; Aged, 80 and over; Biomarkers; Blood Glucose; C-Peptide; Cardiac Surgical Procedures; Cardiopu	2005
Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes. Diabetologia, 1983, Volume: 24, Issue:5 Topics: Adult; Blood Glucose; Diabetes Mellitus; Female; Humans; Insulin; Insulin Infusion Systems; Lactates	1983
Beta-adrenoceptor blockade and recovery from hypoglycaemia in diabetic subjects: normalization after lactate and glycerol infusions. Clinical science (London, England : 1979), 1982, Volume: 62, Issue:2 Topics: Adult; Blood Glucose; Diabetes Mellitus; Epinephrine; Female; Gluconeogenesis; Glycerol; Growth Horm	1982
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind	1995
The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation. Diabetologia, 1998, Volume: 41, Issue:5 Topics: Adult; C-Peptide; Coenzymes; Deafness; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropat	1998
Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 85, Issue:1 Topics: Adult; Autonomic Nervous System; Body Composition; Densitometry; Diabetes Mellitus; Diabetes Mellitu	1998
Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin. Diabetes care, 1998, Volume: 21, Issue:9 Topics: Adult; Blood Glucose; Body Weight; Calorimetry, Indirect; Diabetes Mellitus; Diabetes Mellitus, Type	1998

Article	Year
Hyperlactatemia in diabetic ketoacidosis. Diabetic medicine : a journal of the British Diabetic Association, 2022, Volume: 39, Issue:4 Topics: 3-Hydroxybutyric Acid; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Hyperglycemi	2022
Changes in blood glucose and lactate concentrations with hemodialysis. Artificial organs, 2022, Volume: 46, Issue:1 Topics: Aged; Blood Glucose; Diabetes Mellitus; Female; Glucose; Hemodialysis Solutions; Humans; Hypoglycemi	2022
Machine learning models to predict in-hospital mortality in septic patients with diabetes. Frontiers in endocrinology, 2022, Volume: 13 Topics: Bayes Theorem; Diabetes Mellitus; Hospital Mortality; Humans; Lactic Acid; Machine Learning; Sepsis	2022
Machine learning models to predict in-hospital mortality in septic patients with diabetes. Frontiers in endocrinology, 2022, Volume: 13 Topics: Bayes Theorem; Diabetes Mellitus; Hospital Mortality; Humans; Lactic Acid; Machine Learning; Sepsis	2022
Machine learning models to predict in-hospital mortality in septic patients with diabetes. Frontiers in endocrinology, 2022, Volume: 13 Topics: Bayes Theorem; Diabetes Mellitus; Hospital Mortality; Humans; Lactic Acid; Machine Learning; Sepsis	2022
Machine learning models to predict in-hospital mortality in septic patients with diabetes. Frontiers in endocrinology, 2022, Volume: 13 Topics: Bayes Theorem; Diabetes Mellitus; Hospital Mortality; Humans; Lactic Acid; Machine Learning; Sepsis	2022
Multifunctional porous poly (L-lactic acid) nanofiber membranes with enhanced anti-inflammation, angiogenesis and antibacterial properties for diabetic wound healing. Journal of nanobiotechnology, 2023, Mar-27, Volume: 21, Issue:1 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Chitosan; Diabetes Mellitus; Humans; Lactic Acid; N	2023
Association between elevated lactate and clinical outcomes in adults with diabetic ketoacidosis. Journal of critical care, 2023, Volume: 78 Topics: Adult; Cohort Studies; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Hyperlactatemia; Intensive	2023
The relationship between hyperglycaemia on admission and patient outcome is modified by hyperlactatemia and diabetic status: a retrospective analysis of the eICU collaborative research database. Scientific reports, 2023, 09-21, Volume: 13, Issue:1 Topics: Blood Glucose; Diabetes Mellitus; Humans; Hyperglycemia; Hyperlactatemia; Lactic Acid; Retrospective	2023
Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients. Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:8 Topics: Adult; Age Factors; Area Under Curve; Body Surface Area; Burns; Comorbidity; Debridement; Diabetes M	2019
The NF-κB/miR-425-5p/MCT4 axis: A novel insight into diabetes-induced endothelial dysfunction. Molecular and cellular endocrinology, 2020, 01-15, Volume: 500 Topics: Cell Survival; Diabetes Mellitus; Down-Regulation; Glucose; Human Umbilical Vein Endothelial Cells;	2020
Analysis of the clinical characteristics of 77 COVID-19 deaths. Scientific reports, 2020, 10-02, Volume: 10, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; C-Reactive Protein; Cause of Death; China; Comorbidity; Corona	2020
Identification of risk factors for in-hospital death of COVID - 19 pneumonia -- lessions from the early outbreak. BMC infectious diseases, 2021, Jan-25, Volume: 21, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antivira	2021
Effects of Physiological Doses of Resveratrol and Quercetin on Glucose Metabolism in Primary Myotubes. International journal of molecular sciences, 2021, Jan-30, Volume: 22, Issue:3 Topics: Adult; AMP-Activated Protein Kinases; Diabetes Mellitus; Drug Evaluation, Preclinical; Fatty Acids;	2021
Metformin Does Not Induce Hyperlactatemia in Patients Admitted to Internal Medicine Ward. The Israel Medical Association journal : IMAJ, 2017, Volume: 19, Issue:5 Topics: Acidosis, Lactic; Contraindications, Drug; Diabetes Mellitus; Hospitalization; Humans; Hyperlactatem	2017
Risk factors and outcomes of sepsis-induced myocardial dysfunction and stress-induced cardiomyopathy in sepsis or septic shock: A comparative retrospective study. Medicine, 2018, Volume: 97, Issue:13 Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Comorbidity; Cytokines; Diabetes Mellitus; Echocar	2018
Optimise the microbial flora with milk and yoghurt to prevent disease. Medical hypotheses, 2018, Volume: 114 Topics: Alzheimer Disease; Animals; Autoimmunity; Bacteria; Bifidobacterium; Cattle; Diabetes Mellitus; Ferm	2018
Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism. Scientific reports, 2018, 09-13, Volume: 8, Issue:1 Topics: Animals; Core Binding Factor Alpha 1 Subunit; Diabetes Mellitus; Gene Expression Regulation; Glucose	2018
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. Free radical biology & medicine, 2013, Volume: 60 Topics: Animals; Antioxidants; Diabetes Mellitus; Diketopiperazines; Glucose; Glycation End Products, Advanc	2013
Diabetes: Does lactate sustain brain metabolism during hypoglycaemia? Nature reviews. Endocrinology, 2013, Volume: 9, Issue:7 Topics: Animals; Brain; Diabetes Mellitus; Glucose; Humans; Hypoglycemia; Lactates; Lactic Acid; Rats	2013
The association of plasma lactate with incident cardiovascular outcomes: the ARIC Study. American journal of epidemiology, 2013, Aug-01, Volume: 178, Issue:3 Topics: Alcohol Drinking; Biomarkers; Community-Based Participatory Research; Comorbidity; Coronary Disease;	2013
Assessment of Traub formula and ketone bodies in cause of death investigations. International journal of legal medicine, 2013, Volume: 127, Issue:6 Topics: 3-Hydroxybutyric Acid; Acetoacetates; Acetone; Alcoholism; Algorithms; Autopsy; Biomarkers; Blood Gl	2013
Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery. Chemical biology & drug design, 2014, Volume: 84, Issue:3 Topics: Administration, Oral; Diabetes Mellitus; Drug Carriers; Humans; Hydrogen-Ion Concentration; Insulin;	2014
Profiling of chiral and achiral carboxylic acid metabolomics: synthesis and evaluation of triazine-type chiral derivatization reagents for carboxylic acids by LC-ESI-MS/MS and the application to saliva of healthy volunteers and diabetic patients. Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:3 Topics: Adult; Carboxylic Acids; Chromatography, Liquid; Chromatography, Reverse-Phase; Diabetes Mellitus; F	2015
Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. Journal of controlled release : official journal of the Controlled Release Society, 2015, Jan-10, Volume: 197 Topics: Animals; Catalase; Cells, Cultured; Collagen; Delayed-Action Preparations; Diabetes Mellitus; Drug D	2015
Dried Saliva Spot (DSS) as a Convenient and Reliable Sampling for Bioanalysis: An Application for the Diagnosis of Diabetes Mellitus. Analytical chemistry, 2016, Jan-05, Volume: 88, Issue:1 Topics: Chromatography, High Pressure Liquid; Desiccation; Diabetes Mellitus; Glycated Hemoglobin; Humans; L	2016
Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator. EBioMedicine, 2016, Volume: 7 Topics: Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cell Line;	2016
Validation of the Intensive Care Unit Early Warning Dashboard: Quality Improvement Utilizing a Retrospective Case-Control Evaluation. Telemedicine journal and e-health : the official journal of the American Telemedicine Association, 2017, Volume: 23, Issue:2 Topics: Age Factors; Aged; Algorithms; Case-Control Studies; Decision Support Systems, Clinical; Diabetes Me	2017
Comparative Fingerprinting of the Human Microbiota in Diabetes and Cardiovascular Disease. Journal of medicinal food, 2016, Volume: 19, Issue:12 Topics: Bacterial Load; Bifidobacterium; Cardiovascular Diseases; Clostridium; Diabetes Mellitus; DNA Finger	2016
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department. BMJ open, 2017, 01-30, Volume: 7, Issue:1 Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospit	2017
Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice. Drug delivery, 2017, Volume: 24, Issue:1 Topics: Administration, Oral; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus; Disease Models, A	2017
Analytical investigation: assay of D-lactate in diabetic plasma and urine. Clinical biochemistry, 2008, Volume: 41, Issue:13 Topics: Adult; Aged; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Middle Aged; Stereoisomerism	2008
Poly (lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice. Pharmaceutical research, 2009, Volume: 26, Issue:1 Topics: Animals; Autoimmune Diseases; Blood Glucose; Buffers; Diabetes Mellitus; Drug Delivery Systems; Exci	2009
Brain anomalies in maternally inherited diabetes and deafness syndrome. Journal of neurology, 2009, Volume: 256, Issue:10 Topics: Adult; Aged; Brain; Cerebellar Ataxia; Cognition Disorders; Deafness; Diabetes Mellitus; Diabetes Me	2009
[Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)]. Klinicheskaia laboratornaia diagnostika, 2010, Issue:3 Topics: Animals; Cytosol; Diabetes Mellitus; Diabetic Ketoacidosis; Energy Metabolism; Fatty Acids; Gluconeo	2010
The respiratory quotient and blood pyruvate and lactate responses after oral ingestion of glucose and fructose in diabetes mellitus with and without insulin. The American journal of the medical sciences, 1946, Volume: 211 Topics: Diabetes Mellitus; Diet; Fructose; Glucose; Humans; Insulin; Lactates; Lactic Acid; Pyruvates; Pyruv	1946
Diabetes, metformin and lactic acidosis. Clinical endocrinology, 2011, Volume: 74, Issue:2 Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged	2011
Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes. Biomaterials, 2011, Volume: 32, Issue:6 Topics: Adsorption; Animals; Diabetes Mellitus; Exenatide; Hydrophobic and Hydrophilic Interactions; Hypogly	2011
Insulin-loaded PLGA microparticles: flow focusing versus double emulsion/solvent evaporation. Journal of microencapsulation, 2011, Volume: 28, Issue:5 Topics: Diabetes Mellitus; Drug Carriers; Emulsions; Humans; Insulin; Lactic Acid; Methods; Microspheres; Po	2011
Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. The Journal of biological chemistry, 2011, Dec-30, Volume: 286, Issue:52 Topics: Animals; Aquaporins; CHO Cells; Cricetinae; Cricetulus; Cryoprotective Agents; Diabetes Mellitus; Gl	2011
Metformin intoxication requiring dialysis. Hemodialysis international. International Symposium on Home Hemodialysis, 2011, Volume: 15 Suppl 1 Topics: Acidosis, Lactic; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Metformin; Middle Aged; Rena	2011
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis. British journal of pharmacology, 2012, Volume: 166, Issue:3 Topics: Acidosis, Lactic; Animals; Diabetes Mellitus; Dose-Response Relationship, Drug; HEK293 Cells; Homozy	2012
[Blood glucose, urinary glucose, blood ketone bodies, urine ketone bodies, blood lactic acid, and blood pyruvic acid]. Nihon rinsho. Japanese journal of clinical medicine, 2012, Volume: 70 Suppl 3 Topics: Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Glycosuria; Humans; Ketone Bodies;	2012
Clinical and forensic examinations of glycaemic marker methylglyoxal by means of high performance liquid chromatography-tandem mass spectrometry. International journal of legal medicine, 2013, Volume: 127, Issue:2 Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, Liquid; Diabetes Mellitus; Diabetic Coma; F	2013
Simultaneous determination of DL-lactic acid and DL-3-hydroxybutyric acid enantiomers in saliva of diabetes mellitus patients by high-throughput LC-ESI-MS/MS. Analytical and bioanalytical chemistry, 2012, Volume: 404, Issue:6-7 Topics: 3-Hydroxybutyric Acid; Adult; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus; Female;	2012
Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction. Diabetes, 2013, Volume: 62, Issue:6 Topics: Adenosine Triphosphate; Animals; Azoles; Cells, Cultured; Cyclic N-Oxides; Diabetes Mellitus; Glucok	2013
Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription. The Journal of biological chemistry, 2002, Nov-01, Volume: 277, Issue:44 Topics: Anaerobiosis; Animals; Calcium; Cell Count; Cells, Cultured; Diabetes Mellitus; DNA, Mitochondrial;	2002
Determination of serum D-lactic and L-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization. Analytical and bioanalytical chemistry, 2003, Volume: 377, Issue:5 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus; Fluorescent Dyes; Humans; Lact	2003
Glycemic control in diabetic CAPD patients assessed by continuous glucose monitoring system (CGMS). Kidney international, 2003, Volume: 64, Issue:4 Topics: Adult; Aged; Bicarbonates; Blood Glucose; Buffers; Creatinine; Diabetes Mellitus; Dialysis Solutions	2003
[Study of simultaneous curves of glucose pyruvic acid and lactic acid in blood after second intravenous administration of glucose in normal and diabetic subjects]. Minerva medica, 1953, Nov-10, Volume: 44, Issue:90 Topics: Administration, Intravenous; Blood; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Humans; Lact	1953
Glucose utilization and lactate production by leucocytes of patients with diabetes mellitus. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1957, Volume: 95, Issue:3 Topics: Diabetes Mellitus; Glucose; Humans; Lactates; Lactic Acid; Leukocytes	1957
Studies of the effect of intravenous tolbutamide on pyruvic and lactic acid concentrations in peripheral venous blood in normal and diabetic subjects, and on splanchnic metabolism of fructose and glucose. Annals of the New York Academy of Sciences, 1957, Jul-10, Volume: 71, Issue:1 Topics: Blood Glucose; Diabetes Mellitus; Fructose; Glucose; Humans; Hypoglycemic Agents; Lactic Acid; Pyruv	1957
[Changes of certain metabolic aspects (pyruvic acid, lactic acid, ketone bodies, lipids) in diabetics treated with hypoglycemic sulfonamides]. Minerva medica, 1957, Jul-07, Volume: 48, Issue:54 Topics: Diabetes Mellitus; Humans; Hypoglycemic Agents; Ketone Bodies; Lactic Acid; Lipids; Pyruvates; Pyruv	1957
[Ketonemia, pyruvemia and lacticemia in diabetics treated with carbutamide]. Minerva medica, 1958, Apr-18, Volume: 49, Issue:31 Topics: Carbutamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Ketone Bodies; Ketosis; Lactic Acid; Py	1958
[Research on the blood pyruvic acid and lactic acid levels in diabetics treated with carbutamide and tolbutamide]. Endocrinologia e scienza della costituzione, 1958, Volume: 25, Issue:1 Topics: Carbutamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactic Acid; Pyruvates; Pyruvic Acid; R	1958
[Behavior of blood sugar, blood pyruvate and blood lactic acid after oral glucose loading in 30 elderly diabetics]. Giornale di gerontologia, 1959, Volume: 7 Topics: Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus; Glucose Tolerance Test; Humans; Lactates;	1959
[Behavior of the blood sugar, blood pyruvate and blood lactic acid after insulin loading in a group of 10 elderly diabetics]. Giornale di gerontologia, 1959, Volume: 7 Topics: Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus; Glucose Tolerance Test; Humans; Insulin;	1959
[The action of DOCA on the arteriovenous blood glyco-pyruvico-alcohol-lactic acid pathway in diabetics]. L' Arcispedale S. Anna di Ferrara, 1962, Volume: 15 Topics: Desoxycorticosterone Acetate; Diabetes Mellitus; Ethanol; Lactates; Lactic Acid; Pyruvates	1962
Pyruvate and lactate excretion in patients with diabetes mellitus and benign glycosuria. Lancet (London, England), 1963, Aug-10, Volume: 2, Issue:7302 Topics: Diabetes Mellitus; Glycosuria; Humans; Lactates; Lactic Acid; Pyruvates; Pyruvic Acid	1963
Conversion of DL-lactate-2-C14 or -3-C14 or pyruvate-2-C14 to blood glucose in humans: effects of diabetes, insulin, tolbutamide, and glucose load. The Journal of clinical investigation, 1963, Volume: 42 Topics: Blood Glucose; Diabetes Mellitus; Glucose; Humans; Insulin; Lactates; Lactic Acid; Pyruvates; Pyruvi	1963
LACTATE ACIDOSIS ASSOCIATED WITH PHENFORMIN THERAPY AND LOCALIZED TISSUE HYPOXIA. REPORT OF A CASE TREATED BY HEMODIALYSIS. Annals of internal medicine, 1963, Volume: 59 Topics: Acidosis; Black People; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Ischemia; Kidney; Kidneys,	1963
INCORPORATION OF TRITIUM INTO HUMAN PLASMA TRIGLYCERIDES FROM GLUCOSE-1-H3 AND LACTIC ACID-2-H3. Nature, 1964, Feb-15, Volume: 201 Topics: Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Glucose; Glycerides; Humans; Hydrogen; Lactates;	1964
PATHWAYS OF CARBOHYDRATE FORMATION IN MAN. III. DISTRIBUTION LABELING OF BLOOD GLUCOSE BY DL-LACTATE-2-14C OR PYRUVATE-2-14C IN DIABETIC AND NONDIABETIC SUBJECTS. The Journal of biological chemistry, 1964, Volume: 239 Topics: Blood; Blood Glucose; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus; Drug Therapy; Glu	1964
LACTIC ACID ACIDEMIA AND PHENFORMIN. Rocky Mountain medical journal, 1964, Volume: 61 Topics: Acidosis; Acidosis, Lactic; Blood; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Lactates; Lacti	1964
[STUDY OF FASTING BLOOD LACTIC ACID IN DIABETICS TREATED WITH N-N-DIMETHYLBIGUANIDE]. Le Diabete, 1964, Volume: 12 Topics: Adolescent; Biomedical Research; Blood; Child; Diabetes Mellitus; Drug Therapy; Fasting; Geriatrics;	1964
EFFECT OF LACTIC ACID ON PLASMA FREE FATTY ACIDS IN PANCREATECTOMIZED DOGS. The American journal of physiology, 1964, Volume: 207 Topics: Acetylcholine; Animals; Blood; Diabetes Mellitus; Dogs; Fatty Acids; Fatty Acids, Nonesterified; Glu	1964
[Behavior of blood sugar, blood pyruvate and blood lactic acid after oral sulfanylurea loading in 34 diabetics]. Giornale di gerontologia, 1959, Volume: 7 Topics: Blood Glucose; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Lactic Acid; Pyruvates; Pyr	1959
Thermosensitive hydrogel as a Tgf-beta1 gene delivery vehicle enhances diabetic wound healing. Pharmaceutical research, 2003, Volume: 20, Issue:12 Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Division; Diabetes Complications; Diabetes Mellitu	2003
Insulin and the fate of lactate in the diabetic liver. The Journal of biological chemistry, 1951, Volume: 191, Issue:2 Topics: Acetates; Diabetes Mellitus; Fibrin; Humans; Insulin; Lactates; Lactic Acid; Liver	1951
Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules. Journal of pineal research, 2005, Volume: 38, Issue:3 Topics: Alanine; Animals; Diabetes Mellitus; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycerol; In	2005
Study of energy metabolism of skeletal muscles in alcoholic liver disease--expired gas analysis during exercise. Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:12 Suppl Topics: Adult; Aerobiosis; Anaerobic Threshold; Diabetes Complications; Diabetes Mellitus; Energy Metabolism	2005
Muscle phenotype and mutation load in 51 persons with the 3243A>G mitochondrial DNA mutation. Archives of neurology, 2006, Volume: 63, Issue:12 Topics: Adolescent; Adult; Aged; Anaerobic Threshold; Diabetes Mellitus; DNA, Mitochondrial; Female; Genetic	2006
Thermosensitive hydrogel PEG-PLGA-PEG enhances engraftment of muscle-derived stem cells and promotes healing in diabetic wound. Molecular therapy : the journal of the American Society of Gene Therapy, 2007, Volume: 15, Issue:6 Topics: Animals; Cell Differentiation; Cells, Cultured; Collagen; Dermatologic Surgical Procedures; Diabetes	2007
[Dilated cardiomyopathy, diabetes and deafness related to a mutation of mitochondrial DNA]. Archives des maladies du coeur et des vaisseaux, 2007, Volume: 100, Issue:2 Topics: Cardiomyopathy, Dilated; Deafness; Diabetes Mellitus; DNA, Mitochondrial; Female; Humans; Lactic Aci	2007
[Experience with a super GL analyzer]. Klinicheskaia laboratornaia diagnostika, 2007, Issue:4 Topics: Blood Chemical Analysis; Blood Glucose; Diabetes Mellitus; Female; Humans; Lactic Acid; Male; Retros	2007
Inhibition of gluconeogenesis and glycogenolysis by 2,5-anhydro-D-mannitol. The Journal of biological chemistry, 1984, Jan-10, Volume: 259, Issue:1 Topics: Animals; Blood Glucose; Diabetes Mellitus; Gluconeogenesis; Lactates; Lactic Acid; Liver; Liver Glyc	1984
The role of the anion gap in detecting and managing mixed metabolic acid-base disorders. Clinics in endocrinology and metabolism, 1984, Volume: 13, Issue:2 Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Alkalosis; Alkalosis, Respiratory; Anti-Bacter	1984
The metabolic and hormonal response to acute normoglycaemia in type 1 (insulin-dependent) diabetes: studies with a glucose controlled insulin infusion system (artificial endocrine pancreas). Diabetologia, 1982, Volume: 23, Issue:3 Topics: Adult; Alanine; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucagon; Glyc	1982
Absence of exercise-induced hypoglycaemia in type i (insulin-dependent) diabetic patients during maintenance of normoglycaemia by short-term, open-loop insulin infusion. Diabetologia, 1982, Volume: 23, Issue:4 Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucagon	1982
[The positive inotropic effect of intravenous glucose or insulin-glucose administrations in metabolically healthy probands and in insulin-dependent diabetics]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1982, Sep-01, Volume: 37, Issue:17 Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Fatty Acids,	1982
Exercise in diabetic man: glucose turnover and free insulin responses after glycemic normalization with intravenous insulin. Canadian journal of physiology and pharmacology, 1982, Volume: 60, Issue:10 Topics: Adult; Blood Glucose; Diabetes Mellitus; Humans; Infusions, Parenteral; Insulin; Lactates; Lactic Ac	1982
Effects of pyridoxine alpha-ketoglutarate on blood glucose and lactate in type I and II diabetics. International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:5 Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus; Female; Hemoglobin A; Humans; Lactates; Lactic	1983
The effect of diet on intermediary metabolite concentrations in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 1983, Volume: 24, Issue:5 Topics: 3-Hydroxybutyric Acid; Adult; Aged; Alanine; Diabetes Mellitus; Female; Glycerol; Humans; Hydroxybut	1983
Metabolic and cardiac effects of mild exercise in non-insulin diabetes. Current problems in clinical biochemistry, 1982, Volume: 11 Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Electrocardiography; Heart Rate; Humans; Insulin; Lac	1982
Peripheral insulinaemia and the glucoregulatory response to exercise in diabetic man. Current problems in clinical biochemistry, 1982, Volume: 11 Topics: Blood Glucose; Diabetes Mellitus; Humans; Insulin; Lactates; Lactic Acid; Obesity; Physical Exertion	1982
[Carbohydrate infusion in internal diseases. A comparative study in metabolically healthy, liver diseased and diabetic patients. VI. Infusions of a glucose/xylitol mixture (1:1 ratio) over a 48-hour period]. Infusionstherapie und klinische Ernahrung, 1982, Volume: 9, Issue:2 Topics: Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose; Glucose Solution, Hypertonic;	1982
The effect of pyridoxine-alpha-ketoglutarate (PAK) on exercise-induced increase of blood lactate in patients with type I diabetes. International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:3 Topics: Adolescent; Adult; Aged; Diabetes Mellitus; Double-Blind Method; Female; Humans; Lactates; Lactic Ac	1982
Some practical aspects of physical training and exercise testing in diabetes. Current problems in clinical biochemistry, 1982, Volume: 11 Topics: Diabetes Mellitus; Heart Function Tests; Humans; Lactates; Lactic Acid; Physical Education and Train	1982
Simple filter paper method for home monitoring of blood glucose, lactate, and 3-hydroxybutyrate. Annals of clinical biochemistry, 1981, Volume: 18, Issue:Pt 4 Topics: 3-Hydroxybutyric Acid; Blood Glucose; Blood Specimen Collection; Diabetes Mellitus; Humans; Hydroxyb	1981
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. The New England journal of medicine, 1995, Aug-31, Volume: 333, Issue:9 Topics: Blood Glucose; Body Composition; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Fe	1995
Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM. Diabetes, 1994, Volume: 43, Issue:12 Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting;	1994
Glyoxalase system in clinical diabetes mellitus and correlation with diabetic complications. Clinical science (London, England : 1979), 1994, Volume: 87, Issue:1 Topics: Adult; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathi	1994
Pathogenesis of glucose intolerance and diabetes mellitus in cirrhosis. Hepatology (Baltimore, Md.), 1994, Volume: 19, Issue:3 Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Female; Glucose; Glucose Clamp Technique;	1994
The use of vitreous humor levels of glucose, lactic acid and blood levels of acetone to establish antemortem hyperglycemia in diabetics. Forensic science international, 1994, Volume: 65, Issue:1 Topics: Acetone; Adolescent; Adult; Aged; Aged, 80 and over; Autopsy; Child; Child, Preschool; Death, Sudden	1994
Glucose resistance contributes to diabetes mellitus in cirrhosis. Hepatology (Baltimore, Md.), 1993, Volume: 18, Issue:2 Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Complications; Diabetes Mellitus; Drug Resistance; F	1993
Metabolic and endocrine effects of interleukin-1 in obese, diabetic Zucker fa/fa rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1996, Volume: 104, Issue:4 Topics: Animals; Blood Glucose; Cholesterol; Corticosterone; Diabetes Mellitus; Diabetes Mellitus, Type 2; D	1996
Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose conditions. Diabetologia, 1996, Volume: 39, Issue:11 Topics: Animals; Cattle; Cell Count; Cell Division; Cells, Cultured; Diabetes Mellitus; Endothelium; Endothe	1996
Commercial biosensors for medical application. EXS, 1997, Volume: 81 Topics: Biosensing Techniques; Blood Glucose; Clinical Laboratory Techniques; Diabetes Mellitus; Enzymes, Im	1997
Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes, 1998, Volume: 47, Issue:11 Topics: Adult; Alanine; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Exercise; Fe	1998
Consequences of metformin intoxication. Diabetes care, 1998, Volume: 21, Issue:11 Topics: Adolescent; Adult; Blood Glucose; Creatinine; Diabetes Complications; Diabetes Mellitus; Female; Hum	1998
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis. Biochemistry and molecular biology international, 1998, Volume: 46, Issue:3 Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An	1998
How can hemodialysis-associated hypotension and dialysis-induced symptoms be explained and controlled--particularly in diabetic and arteriosclerotic patients? Clinical nephrology, 2000, Volume: 53, Issue:1 Suppl Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Electroencephalography; Humans; Hypoten	2000
Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. Journal of controlled release : official journal of the Controlled Release Society, 2000, Jul-03, Volume: 67, Issue:2-3 Topics: Animals; Carbonates; Delayed-Action Preparations; Diabetes Mellitus; Drug Compounding; Female; Insul	2000
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro. Journal of biochemistry, 2001, Volume: 129, Issue:4 Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans;	2001
Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa. The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:7 Topics: Adipose Tissue; Adult; Black People; Body Composition; C-Peptide; Diabetes Mellitus; Diabetes Mellit	2001
Glucose and lactate in vitreous humor compared with the determination of fructosamine for the postmortem diagnosis of diabetes mellitus. The American journal of forensic medicine and pathology, 2001, Volume: 22, Issue:3 Topics: Adult; Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus; Female; Forensic Anthropology; Fru	2001
Glucose kinetics and splanchnic uptake following mixed meal ingestion in cirrhotic-diabetic subjects. Diabetes, nutrition & metabolism, 2001, Volume: 14, Issue:6 Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Dietary Carbohydrates; Fatty Acids,	2001
Clinical aspects of mitochondrial disorders. Journal of inherited metabolic disease, 1992, Volume: 15, Issue:4 Topics: Child, Preschool; Coma; Diabetes Mellitus; DNA, Mitochondrial; Dwarfism; Female; Heart Diseases; Hum	1992
Postprandial thermogenesis at rest and postexercise before and after physical training in lean, obese, and mildly diabetic men. Metabolism: clinical and experimental, 1992, Volume: 41, Issue:8 Topics: Adult; Analysis of Variance; Blood Glucose; Body Temperature Regulation; Diabetes Mellitus; Diabetes	1992
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. The Journal of clinical endocrinology and metabolism, 1991, Volume: 73, Issue:6 Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fasting; Female; Glucose;	1991
Lactate generation following glucose ingestion: relation to obesity, carbohydrate tolerance and insulin sensitivity. International journal of obesity, 1990, Volume: 14, Issue:10 Topics: Adult; Blood Glucose; Body Mass Index; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Carbohy	1990
[Significance of lactate analysis in clinical tests]. Nihon rinsho. Japanese journal of clinical medicine, 1989, Volume: 48 Suppl Topics: Acidosis, Lactic; Diabetes Mellitus; Heart Diseases; Humans; Lactates; Lactic Acid; Liver Diseases;	1989
Pancreatic alpha- and beta-cell function and metabolic changes during oral L-alanine and glucose administration: comparative studies between normal, diabetic and cirrhotic subjects. Nagoya journal of medical science, 1989, Volume: 51, Issue:1-4 Topics: Administration, Oral; Adult; Alanine; Blood Glucose; Diabetes Mellitus; Female; Glucose; Glucose Tol	1989
Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma. Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:3 Topics: Brain Damage, Chronic; Diabetes Mellitus; Diabetic Coma; Diabetic Neuropathies; Female; Humans; Hypo	1989
[Post-fructose increase in the blood level of lactic acid in various pathologic conditions]. Polskie Archiwum Medycyny Wewnetrznej, 1987, Volume: 77, Issue:6 Topics: Aged; Bronchitis; Chronic Disease; Diabetes Mellitus; Female; Fructose; Humans; Infusions, Intraveno	1987
[Glucose, lactic acid and pyruvic acid levels of the blood and cerebrospinal fluid in patients with diabetes mellitus and cerebral infarction]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 1987, Jul-15, Volume: 40, Issue:14 Topics: Aged; Blood Glucose; Cerebral Infarction; Diabetes Mellitus; Female; Glucose; Humans; Lactates; Lact	1987
[Biochemical measurements of glucose metabolism in relation to cause of death and postmortem effects]. Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 1986, Volume: 96, Issue:3 Topics: Acetone; Blood Glucose; Diabetes Mellitus; Diabetic Coma; Glycated Hemoglobin; Hemorrhage; Humans; L	1986
Effects of fructose feeding on lipid parameters in obese and lean, diabetic and nondiabetic Zucker rats. The Journal of nutrition, 1985, Volume: 115, Issue:10 Topics: Animals; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dietary Carbo	1985

lactic acid and Diabetes Mellitus