Page last updated: 2024-10-17

lactic acid and Dermatoses

lactic acid has been researched along with Dermatoses in 39 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"In order to investigate the efficacy of anthralin ( Anthraderm ) in the treatment of warts a randomized controlled trial was carried out in 72 patients."5.05Wart treatment with anthralin. ( Brandrup, F; Flindt-Hansen, H; Tikjøb, G, 1984)
" OBJECTIVE To review the use of injectable PLLA, specifically regarding optimal injection technique that can reduce adverse events (AEs) and enhance out comes."2.44Minimizing adverse events associated with poly-L-lactic acid injection. ( Narins, RS, 2008)
"Vancomycin was linked to the injectable hydrogel via the reversible Schiff's base reaction, and VEGF were encapsulated into PLGA microspheres."1.48Tunable sequential drug delivery system based on chitosan/hyaluronic acid hydrogels and PLGA microspheres for management of non-healing infected wounds. ( Chen, G; Huang, J; Li, Z; Liu, Y; Ren, J; Wang, G; Wu, X, 2018)
"Polylactic acid (PLA) is an agent that is injected with the aim of enhancing the host's own collagen deposition."1.34Adverse reactions to polylactic acid injections in the periorbital area. ( Apikian, M; Goodman, GJ; Roberts, S, 2007)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19908 (20.51)18.7374
1990's6 (15.38)18.2507
2000's9 (23.08)29.6817
2010's11 (28.21)24.3611
2020's5 (12.82)2.80

Authors

AuthorsStudies
Corazza, M1
Guarneri, F1
Montesi, L1
Toni, G1
Donelli, I1
Borghi, A1
Zhou, LD1
Lu, YN1
Liu, Q1
Shi, XM1
Tian, J1
Liu, M1
Yu, W1
Fang, Y1
Zhou, H1
Liang, Y1
Huang, C1
Liu, H1
Zhao, G1
Jiang, WC1
Zhang, H1
Xu, Y2
Jiang, C1
Liu, W1
Tan, Y1
Zheng, Y1
Liang, H1
Li, Z2
Tang, M1
Song, L1
Huang, J1
Ren, J1
Chen, G1
Liu, Y1
Wang, G1
Wu, X1
Lee, KC1
Wambier, CG1
Soon, SL1
Sterling, JB1
Landau, M1
Rullan, P1
Brody, HJ1
Daines, SM1
Williams, EF1
Salam, A1
Dadzie, OE1
Galadari, H1
Chiang, WL1
Lin, TT1
Sureshbabu, R1
Chia, WT1
Hsiao, HC1
Liu, HY1
Yang, CM1
Sung, HW1
Zhu, X1
Zeng, X1
Zhang, X1
Cao, W1
Wang, Y1
Chen, H1
Wang, T1
Tsai, HI1
Zhang, R1
Chang, D1
He, S1
Mei, L1
Shi, X1
Ehnis-Pérez, A1
Torres-Álvarez, B1
Cortés-García, D1
Hernández-Blanco, D1
Fuentes-Ahumada, C1
Castanedo-Cázares, JP1
Narins, RS1
Cohen, JL1
Rancan, F1
Papakostas, D1
Hadam, S1
Hackbarth, S1
Delair, T1
Primard, C1
Verrier, B1
Sterry, W1
Blume-Peytavi, U1
Vogt, A1
WOHNLICH, H1
Davis, JA1
Visscher, MO1
Wickett, RR1
Hoath, SB1
STERN, EC1
Sadick, NS1
Coutanceau, C1
Sibaud, V1
Merial-Kieny, C1
Shirali, AC1
Look, M1
Du, W1
Kassis, E1
Stout-Delgado, HW1
Fahmy, TM1
Goldstein, DR1
Mohr, B1
Fernandez, MP1
Krejci-Manwaring, J1
LEBENGLIK, M1
KAMINSKY, A1
Godfried, MH1
Boer, K1
Beuger, S1
Scherpbier, HJ1
Kuijpers, TW1
Hodzic-Avdagic, N1
Stege, H1
Hilton, S1
Sarbia, M1
Ruzicka, T1
Bruch-Gerharz, D1
Apikian, M1
Roberts, S1
Goodman, GJ1
COCA, AF1
Pons-Guiraud, A1
Rongioletti, F1
Flindt-Hansen, H1
Tikjøb, G1
Brandrup, F1
Kanno, T1
Maekawa, M1
Berg, M1
Lonne-Rahm, SB1
Fischer, T1
Coverly, J1
Peters, L1
Whittle, E1
Basketter, DA1
Burmeister, JE1
Fox, LK1
Hillers, JK1
Hancock, DD1
Muizzuddin, N1
Marenus, KD1
Maes, DH1
Takken, W1
Lachapelle, JM1
Leroy, B1
Van Scott, EJ1
Yu, RJ1
Baden, HP1
Mayron, R1
Grimwood, RE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
6 Month Double-Blind Randomized Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Small Particle Hyaluronic Acid to Treat Acne Scars Located on the Cheeks and Forehead[NCT02955381]26 participants (Actual)Interventional2017-03-28Terminated (stopped due to Liquidation of Research Department)
A Single Center Clinical Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris[NCT03128723]45 participants (Actual)Interventional2017-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cutaneous Tolerance Scores: Burning/Stinging

Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 14. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.02

Cutaneous Tolerance Scores: Burning/Stinging

Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 28. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Dryness/Scaling

Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 14. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.11

Cutaneous Tolerance Scores: Dryness/Scaling

Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 28. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.14

Cutaneous Tolerance Scores: Edema

Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 14. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Edema

Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 28. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Erythema

Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 14. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.09

Cutaneous Tolerance Scores: Erythema

Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 28. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.07

Cutaneous Tolerance Scores: Itching

Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 14. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask0.04

Cutaneous Tolerance Scores: Itching

Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 28. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask0.00

Cutaneous Tolerance Scores: Tightness/Dry

Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 14. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 14

InterventionUnits on a scale (Mean)
Acne Mask-0.02

Cutaneous Tolerance Scores: Tightness/Dry Feeling

Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 28. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 28

InterventionUnits on a scale (Mean)
Acne Mask-0.05

Reviews

4 reviews available for lactic acid and Dermatoses

ArticleYear
Basic chemical peeling: Superficial and medium-depth peels.
    Journal of the American Academy of Dermatology, 2019, Volume: 81, Issue:2

    Topics: Caustics; Chemexfoliation; Drug Combinations; Ethanol; Glycolates; Humans; Keratolytic Agents; Lacti

2019
Chemical peeling in ethnic skin: an update.
    The British journal of dermatology, 2013, Volume: 169 Suppl 3

    Topics: Caustics; Chemexfoliation; Combined Modality Therapy; Humans; Keratolytic Agents; Lactic Acid; Medic

2013
Minimizing adverse events associated with poly-L-lactic acid injection.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2008, Volume: 34 Suppl 1

    Topics: Cellulose; Cosmetic Techniques; Drug Compounding; Face; Female; Granuloma, Foreign-Body; HIV-Associa

2008
Understanding, avoiding, and managing dermal filler complications.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2008, Volume: 34 Suppl 1

    Topics: Animals; Biocompatible Materials; Cattle; Collagen; Cosmetic Techniques; Durapatite; Female; Foreign

2008

Trials

2 trials available for lactic acid and Dermatoses

ArticleYear
Efficacy and safety of a new topical keratolytic treatment for localized hyperkeratosis in adults.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:12

    Topics: Administration, Topical; Adult; Double-Blind Method; Drug Delivery Systems; Drug Tolerance; Europe;

2010
Wart treatment with anthralin.
    Acta dermato-venereologica, 1984, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Anthracenes; Anthralin; Child; Clinical Trials as Topic; Copper; Drug Combination

1984

Other Studies

33 other studies available for lactic acid and Dermatoses

ArticleYear
Proposal of a self-assessment questionnaire for the diagnosis of sensitive skin.
    Journal of cosmetic dermatology, 2022, Volume: 21, Issue:6

    Topics: Adult; Cross-Sectional Studies; Humans; Lactic Acid; Reproducibility of Results; Self-Assessment; Sk

2022
Modulation of TRPV1 function by Citrus reticulata (tangerine) fruit extract for the treatment of sensitive skin.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:4

    Topics: Capsaicin; Citrus; Fruit; Humans; Lactic Acid; Pain; Plant Extracts; Skin Diseases; TRPV Cation Chan

2023
Pyruvate and lactate based hydrogel film inhibits UV radiation-induced skin inflammation and oxidative stress.
    International journal of pharmaceutics, 2023, Mar-05, Volume: 634

    Topics: Dihydroxyphenylalanine; Humans; Hydrogels; Inflammation; Lactic Acid; Oxidative Stress; Pyruvic Acid

2023
Cutaneous vessel features of sensitive skin and its underlying functions.
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2020, Volume: 26, Issue:3

    Topics: Adult; Capsaicin; Case-Control Studies; China; Female; Humans; Lactic Acid; Male; Microvascular Dens

2020
Skin microbiome in sensitive skin: The decrease of Staphylococcus epidermidis seems to be related to female lactic acid sting test sensitive skin.
    Journal of dermatological science, 2020, Volume: 97, Issue:3

    Topics: Cosmetics; DNA, Bacterial; Female; Humans; Hyperesthesia; Lactic Acid; Microbiota; RNA, Ribosomal, 1

2020
Tunable sequential drug delivery system based on chitosan/hyaluronic acid hydrogels and PLGA microspheres for management of non-healing infected wounds.
    Materials science & engineering. C, Materials for biological applications, 2018, Aug-01, Volume: 89

    Topics: Animals; Bacteria; Biocompatible Materials; Cell Proliferation; Chitosan; Cytokines; Drug Carriers;

2018
Complications associated with injectable soft-tissue fillers: a 5-year retrospective review.
    JAMA facial plastic surgery, 2013, Volume: 15, Issue:3

    Topics: Adult; Aged; Biocompatible Materials; Cosmetic Techniques; Durapatite; Female; Follow-Up Studies; Hu

2013
A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Feb-10, Volume: 199

    Topics: Abscess; Animals; Anti-Bacterial Agents; Drug Delivery Systems; Hot Temperature; Infrared Rays; Inje

2015
The effects of quercetin-loaded PLGA-TPGS nanoparticles on ultraviolet B-induced skin damages in vivo.
    Nanomedicine : nanotechnology, biology, and medicine, 2016, Volume: 12, Issue:3

    Topics: Animals; Antioxidants; Cell Line; Drug Carriers; Female; Humans; Keratinocytes; Lactic Acid; Mice; N

2016
Relationship between transient receptor potential vanilloid-1 expression and the intensity of sensitive skin symptoms.
    Journal of cosmetic dermatology, 2016, Volume: 15, Issue:3

    Topics: Adult; Female; Gene Expression; Humans; Hyperesthesia; Lactic Acid; Male; Middle Aged; RNA, Messenge

2016
Investigation of polylactic acid (PLA) nanoparticles as drug delivery systems for local dermatotherapy.
    Pharmaceutical research, 2009, Volume: 26, Issue:8

    Topics: Dermatologic Agents; Drug Delivery Systems; Humans; Lactic Acid; Nanoparticles; Polyesters; Polymers

2009
Mix with lactic acid lactate buffer to treat inflammatory dermatoses.
    Medizinische Klinik, 1946, Volume: 41, Issue:18

    Topics: Humans; Lactates; Lactic Acid; Skin Diseases

1946
Role of TNF-α polymorphism -308 in neurosensory irritation.
    International journal of cosmetic science, 2011, Volume: 33, Issue:2

    Topics: Adult; DNA; Dose-Response Relationship, Drug; Female; Genotype; Humans; Lactic Acid; Male; Middle Ag

2011
Topical application of lactic acid in the treatment and prevention of certain disorders of the skin.
    The Urologic and cutaneous review, 1946, Volume: 50

    Topics: Humans; Lactic Acid; Skin; Skin Diseases

1946
Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011, Volume: 11, Issue:12

    Topics: Animals; Antibiotics, Antineoplastic; B7-H1 Antigen; Cells, Cultured; Combined Modality Therapy; Den

2011
Eruptive keratoacanthomas after Jessners and trichloroacetic acid peel for actinic keratosis.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013, Volume: 39, Issue:2

    Topics: Chemexfoliation; Drug Combinations; Ethanol; Humans; Keratoacanthoma; Keratosis, Actinic; Lactic Aci

2013
[Dextro-rotarory lactic acid and racemic lactic acid in the treatment of psoriasis and parakeratotic dermatosis].
    Revista de la Asociacion Medica Argentina, 1961, Volume: 75

    Topics: Dermatology; Lactates; Lactic Acid; Psoriasis; Skin Diseases

1961
A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother.
    European journal of pediatrics, 2005, Volume: 164, Issue:3

    Topics: Adipose Tissue; Antiretroviral Therapy, Highly Active; Arginine; Asphyxia; Brain; Cardiomegaly; Card

2005
[Granuloma development after wrinkle injection with polylactate].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2005, Volume: 56, Issue:4

    Topics: Cosmetic Techniques; Female; Granuloma; Humans; Injections, Subcutaneous; Lactic Acid; Middle Aged;

2005
Adverse reactions to polylactic acid injections in the periorbital area.
    Journal of cosmetic dermatology, 2007, Volume: 6, Issue:2

    Topics: Cellulose; Cosmetic Techniques; Dermatologic Agents; Face; Female; Granuloma, Foreign-Body; Humans;

2007
The factor L. casei in the therapy of certain dermatological syndromes; Folic acid (transl.).
    Jornada medica, 1948, Volume: 2, Issue:18

    Topics: Bacteria; Lactic Acid; Lactobacillus; Skin Diseases

1948
[Classification of the fillers available in France].
    Annales de dermatologie et de venereologie, 2008, Volume: 135, Issue:1 Pt 2

    Topics: Absorbable Implants; Biocompatible Materials; Cosmetic Techniques; France; Granuloma; Humans; Hyalur

2008
[Granulomatous reactions from aesthetic dermal micro-implants].
    Annales de dermatologie et de venereologie, 2008, Volume: 135, Issue:1 Pt 2

    Topics: Absorbable Implants; Acrylates; Biocompatible Materials; Collagen; Cosmetic Techniques; Dimethylpoly

2008
Lactate dehydrogenase M-subunit deficiencies: clinical features, metabolic background, and genetic heterogeneities.
    Muscle & nerve. Supplement, 1995, Volume: 3

    Topics: Adolescent; Adult; Base Sequence; DNA; Exercise; Female; Glyceraldehyde-3-Phosphate Dehydrogenases;

1995
Patients with visual display unit-related facial symptoms are stingers.
    Acta dermato-venereologica, 1998, Volume: 78, Issue:1

    Topics: Adult; Computer Terminals; Dermatitis, Contact; Female; Humans; Irritants; Lactic Acid; Male; Occupa

1998
Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?
    Contact dermatitis, 1998, Volume: 38, Issue:2

    Topics: Acrolein; Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents; Antimutagenic Age

1998
Effects of premilking and postmilking teat disinfectants on teat skin condition.
    Journal of dairy science, 1998, Volume: 81, Issue:7

    Topics: Animals; Body Water; Cattle; Cattle Diseases; Chlorides; Disinfectants; Epidermis; Female; Iodine; L

1998
Factors defining sensitive skin and its treatment.
    American journal of contact dermatitis : official journal of the American Contact Dermatitis Society, 1998, Volume: 9, Issue:3

    Topics: Adult; Balsams; Cosmetics; Dermatitis, Contact; Dermatologic Agents; Epidermis; Erythema; Exanthema;

1998
Malaria mosquitoes favor the human skin and not expired air.
    International journal of dermatology, 2000, Volume: 39, Issue:3

    Topics: Animals; Anopheles; Humans; Insect Bites and Stings; Lactic Acid; Malaria; Odorants; Skin; Skin Dise

2000
Allergic contact dermatitis to colophony included in the formulation of flexible collodion BP, the vehicle of a salicylic and lactic acid wart paint.
    Dermatologic clinics, 1990, Volume: 8, Issue:1

    Topics: Adult; Collodion; Dermatitis, Contact; Female; Humans; Lactates; Lactic Acid; Patch Tests; Pharmaceu

1990
Alpha hydroxy acids: procedures for use in clinical practice.
    Cutis, 1989, Volume: 43, Issue:3

    Topics: Acne Vulgaris; Administration, Topical; Glycolates; Humans; Ichthyosis; Keratosis; Lactates; Lactic

1989
Management of fingertip cracking with Epilyt.
    Journal of the American Academy of Dermatology, 1989, Volume: 20, Issue:6

    Topics: Butylated Hydroxytoluene; Drug Combinations; Fingers; Humans; Lactates; Lactic Acid; Propylene Glyco

1989
Familial occurrence of eruptive vellus hair cysts.
    Pediatric dermatology, 1988, Volume: 5, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Age Factors; Biopsy; Child; Child, Preschool; Diagnosis, Diff

1988