lactic acid has been researched along with Dermatitis, Contact in 13 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Dermatitis, Contact: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Also, in spite of the variability in perceived responses to the recalled/imagined skin sensations, statistically significant dose-response and time-response patterns were observed in chemical (lactic acid and capsaicin) challenge studies." | 2.70 | Evaluation of a quantitative clinical method for assessment of sensory skin irritation. ( Perkins, MA; Robinson, MK, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oh, M | 1 |
| Lee, J | 1 |
| Kim, S | 1 |
| Cho, SA | 1 |
| Lee, E | 1 |
| Yeon, JH | 1 |
| He, QQ | 1 |
| Liu, W | 1 |
| Wang, XM | 1 |
| Li, L | 1 |
| Lai, W | 1 |
| Liang, H | 1 |
| Gao, XH | 1 |
| Shin, K | 1 |
| An, S | 1 |
| Adamides, AA | 1 |
| Rosenfeldt, FL | 1 |
| Winter, CD | 1 |
| Pratt, NM | 1 |
| Tippett, NJ | 1 |
| Lewis, PM | 1 |
| Bailey, MJ | 1 |
| Cooper, DJ | 1 |
| Rosenfeld, JV | 1 |
| Fisher, AA | 1 |
| Cramers, M | 1 |
| Thormann, J | 1 |
| Issachar, N | 1 |
| Gall, Y | 1 |
| Borell, MT | 1 |
| Poelman, MC | 1 |
| Berardesca, E | 1 |
| Distante, F | 1 |
| Vignoli, GP | 1 |
| Oresajo, C | 1 |
| Green, B | 1 |
| Berg, M | 1 |
| Lonne-Rahm, SB | 1 |
| Fischer, T | 1 |
| Coverly, J | 1 |
| Peters, L | 1 |
| Whittle, E | 1 |
| Basketter, DA | 1 |
| Seidenari, S | 1 |
| Francomano, M | 1 |
| Mantovani, L | 1 |
| Muizzuddin, N | 1 |
| Marenus, KD | 1 |
| Maes, DH | 1 |
| Robinson, MK | 1 |
| Perkins, MA | 1 |
| Lachapelle, JM | 1 |
| Leroy, B | 1 |
| Shehade, SA | 1 |
| Foulds, IS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determination of Sensitive Skin in a Mexican Population by Lactic Acid Testing and Its Analysis Through Biophysical Measures[NCT01591993] | Phase 4 | 260 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| A Single Center Clinical Study to Evaluate the Tolerance of an Acne Treatment in Sensitive Skin Subjects With Mild to Moderate Acne Vulgaris[NCT03128723] | 45 participants (Actual) | Interventional | 2017-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 14. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.02 |
Cutaneous Tolerance Scores: Burning/Stinging (assessing skin burning/stinging), from Baseline to Day 28. Scale range is 0-3 where 0 = no burning/stinging, 1 = mild burning/stinging, 2 = moderate burning/stinging, and 3 = severe burning/stinging. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 14. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.11 |
Cutaneous Tolerance Scores: Dryness/Scaling (assessing skin dryness), from Baseline to Day 28. Scale range is 0-3, where 0 = no dryness, 1 = mild dryness, 2 = moderate dryness, and 3 = severe dryness. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.14 |
Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 14. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Edema (assessing skin edema/swelling), from Baseline to Day 28. Scale range is 0-3 where 0 = no edema, 1 = mild edema, 2 = moderate edema, and 3 = severe edema. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 14. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.09 |
Cutaneous Tolerance Scores: Erythema (assessing skin redness), from Baseline to Day 28. Scale range is 0-3 where 0 = no redness, 1 = mild redness, 2 = moderate redness, and 3 = severe redness. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.07 |
Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 14. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.04 |
Cutaneous Tolerance Scores: Itching (assessing skin itching), from Baseline to Day 28. Scale range is 0-3 where 0 = no itching, 1 = mild itching, 2 = moderate itching, and 3 = severe itching. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | 0.00 |
Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 14. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 14
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.02 |
Cutaneous Tolerance Scores: Tightness/Dry Feeling (assessing skin tightness/dry feeling), from Baseline to Day 28. Scale range is 0-3 where 0 = no tightness/dry feeling, 1 = mild tightness/dry feeling, 2 = moderate tightness/dry feeling, and 3 = severe tightness/dry feeling. (NCT03128723)
Timeframe: Baseline to Day 28
| Intervention | Units on a scale (Mean) |
|---|---|
| Acne Mask | -0.05 |
3 trials available for lactic acid and Dermatitis, Contact
| Article | Year |
|---|---|
Alpha hydroxyacids modulate stratum corneum barrier function.
Topics: Adult; Dermatitis, Contact; Double-Blind Method; Epidermis; Gluconates; Glycolates; Humans; Hydroxy | 1997 |
Baseline biophysical parameters in subjects with sensitive skin.
Topics: Adult; Biophysical Phenomena; Biophysics; Dermatitis, Contact; Dermatitis, Irritant; Female; Galvani | 1998 |
Evaluation of a quantitative clinical method for assessment of sensory skin irritation.
Topics: Adult; Capsaicin; Dermatitis, Contact; Dose-Response Relationship, Drug; Female; Humans; Irritants; | 2001 |
10 other studies available for lactic acid and Dermatitis, Contact
| Article | Year |
|---|---|
Regional and seasonal differences in skin irritation and neurosensitivity in Chinese and South Korean women.
Topics: Adult; Capsaicin; China; Dermatitis, Contact; Female; Healthy Volunteers; Humans; Lactic Acid; Pain; | 2015 |
Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury.
Topics: Adolescent; Adult; Aged; Area Under Curve; Australia; Biomarkers; Brain; Brain Injuries; Dermatitis, | 2009 |
Irritant and toxic reactions to phenol in topical medications.
Topics: Adult; Aged; Candidiasis, Cutaneous; Dermatitis, Contact; Drug Combinations; Drug Eruptions; Eczema; | 1980 |
Skin reactions to a urea-containing cream.
Topics: Adolescent; Adult; Aged; Dermatitis, Contact; Dermatologic Agents; Drug Combinations; Drug Hypersens | 1981 |
pH measurements during lactic acid stinging test in normal and sensitive skin.
Topics: Adult; Case-Control Studies; Cosmetics; Dermatitis, Contact; Face; Female; Forearm; Humans; Hydrogen | 1997 |
Patients with visual display unit-related facial symptoms are stingers.
Topics: Adult; Computer Terminals; Dermatitis, Contact; Female; Humans; Irritants; Lactic Acid; Male; Occupa | 1998 |
Susceptibility to skin stinging, non-immunologic contact urticaria and acute skin irritation; is there a relationship?
Topics: Acrolein; Acute Disease; Administration, Topical; Adult; Anti-Inflammatory Agents; Antimutagenic Age | 1998 |
Factors defining sensitive skin and its treatment.
Topics: Adult; Balsams; Cosmetics; Dermatitis, Contact; Dermatologic Agents; Epidermis; Erythema; Exanthema; | 1998 |
Allergic contact dermatitis to colophony included in the formulation of flexible collodion BP, the vehicle of a salicylic and lactic acid wart paint.
Topics: Adult; Collodion; Dermatitis, Contact; Female; Humans; Lactates; Lactic Acid; Patch Tests; Pharmaceu | 1990 |
Allergic contact dermatitis to Brilliant Green.
Topics: Dermatitis, Contact; Drug Combinations; Drug Eruptions; Female; Humans; Lactates; Lactic Acid; Middl | 1986 |