lactic acid has been researched along with Depressive Disorder, Major in 9 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (22.22) | 29.6817 |
2010's | 6 (66.67) | 24.3611 |
2020's | 1 (11.11) | 2.80 |
Authors | Studies |
---|---|
Wang, J | 1 |
Lu, T | 1 |
Gui, Y | 1 |
Zhang, X | 1 |
Cao, X | 1 |
Li, Y | 1 |
Li, C | 1 |
Liu, L | 1 |
Ding, Z | 1 |
Murack, M | 1 |
Messier, C | 1 |
Postaci, A | 1 |
Tiryaki, C | 1 |
Sacan, O | 1 |
Ornek, D | 1 |
Kalyoncu, M | 1 |
Dikmen, B | 1 |
Bradley, KA | 1 |
Mao, X | 2 |
Case, JA | 1 |
Kang, G | 1 |
Shungu, DC | 2 |
Gabbay, V | 1 |
Ernst, J | 1 |
Hock, A | 1 |
Henning, A | 1 |
Seifritz, E | 1 |
Boeker, H | 1 |
Grimm, S | 1 |
Carrard, A | 1 |
Elsayed, M | 1 |
Margineanu, M | 1 |
Boury-Jamot, B | 1 |
Fragnière, L | 1 |
Meylan, EM | 1 |
Petit, JM | 1 |
Fiumelli, H | 1 |
Magistretti, PJ | 1 |
Martin, JL | 1 |
Murrough, JW | 1 |
Collins, KA | 1 |
Kelly, C | 1 |
Andrade, G | 1 |
Nestadt, P | 1 |
Levine, SM | 1 |
Mathew, SJ | 1 |
Kubesch, S | 1 |
Bretschneider, V | 1 |
Freudenmann, R | 1 |
Weidenhammer, N | 1 |
Lehmann, M | 1 |
Spitzer, M | 1 |
Grön, G | 1 |
Mendhekar, DN | 1 |
Benuiwal, RP | 1 |
Puri, V | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Impacts of Yoga and Aerobic Exercise on Neuro-cognitive Function and Symptoms in Early Psychosis - A Single-blind Randomized Controlled Clinical Trial[NCT01207219] | 140 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"measured by Letter Cancellation test Q score. The basic version of the task consists of six 52-character rows in which the target character is randomly interspersed approximately 18 times in each row. Subjects were asked to cancel the letter C and E as quickly as possible. The time to completion, number of error and omission items were recorded. A quality of search index (Q), developed by Geldmacher et al., was applied for the analysis. Q is the ratio of correct number to total number of targets multiplied by the ratio of correct number per second. Higher Q scores represent more efficient performance and better attention and concentration. Q scores could range from 0 (worst possible outcome) to 1 (best possible outcome)." (NCT01207219)
Timeframe: baseline and 12 weeks
Intervention | Correct number per second (Mean) | |
---|---|---|
Baseline | 12 weeks | |
Aerobic Exercise | 0.71 | 0.77 |
Waitlist Control Group | 0.74 | 0.73 |
Yoga Therapy | 0.76 | 0.84 |
PANSS total score is computed by summing the scores of positive, negative and general symptom subscores. The range of PANSS total score is from 30 to 210, range of PANSS positive and negative subscores is from 7 to 49, range of PANSS general symptoms subscore is from 16 to 112, with higher values representing worse outcome. CDS total score is computed by summing the scores of nine items of the scale. The range of CDS total score is from 0 to 27, with higher values representing worse outcome. (NCT01207219)
Timeframe: Baseline and 12 weeks
Intervention | units on a scale (Mean) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
PANSS total score-Baseline | PANSS total score-12 weeks | PANSS positive subscore-Baseline | PANSS positive subscore-12 weeks | PANSS negative subscore-Baseline | PANSS negative subscore-12 weeks | PANSS general symptoms-Baseline | PANSS general symptoms-12 weeks | CDS-Baseline | CDS-12 weeks | |
Aerobic Exercise | 46.8 | 39.5 | 9.7 | 8.3 | 11.2 | 9.7 | 25.9 | 21.6 | 3.4 | 1.7 |
Waitlist Control Group | 45.4 | 49.0 | 9.8 | 10.0 | 11.2 | 12.6 | 24.5 | 26.4 | 3.7 | 4.3 |
Yoga Therapy | 46.9 | 37.4 | 9.9 | 8.4 | 11.0 | 8.7 | 26.0 | 20.3 | 3.6 | 1.7 |
Total number of corrected encoded words in the first three trials in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks
Intervention | correctly encoded words (Mean) | |
---|---|---|
Baseline | 12 weeks | |
Aerobic Exercise | 22.0 | 28.8 |
Waitlist Control Group | 22.7 | 24.8 |
Yoga Therapy | 22.8 | 29.5 |
The total number of correctly recalled words after short-term (10 minutes) and long-term (30 minutes) delay in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks
Intervention | correctly recorded words (Mean) | |
---|---|---|
Baseline | 12 weeks | |
Aerobic Exercise | 15.1 | 21.0 |
Waitlist Control Group | 14.5 | 16.6 |
Yoga Therapy | 14.9 | 19.4 |
measured by Digit Span backwards test. In this test, the subject was asked to recall a series of numbers in reverse order. The correctly recalled series were scored as 1, and the test contains 14 sequences of numbers. The range of working memory score is from 0 to 14, with higher values representing better outcome. (NCT01207219)
Timeframe: baseline and 12 weeks
Intervention | Scores on a scale (Mean) | |
---|---|---|
Baseline | 12 weeks | |
Aerobic Exercise | 6.8 | 9.4 |
Waitlist Control Group | 7.1 | 7.7 |
Yoga Therapy | 6.8 | 8.5 |
1 trial available for lactic acid and Depressive Disorder, Major
Article | Year |
---|---|
Aerobic endurance exercise improves executive functions in depressed patients.
Topics: Adult; Attention; Cognition Disorders; Depressive Disorder, Major; Discrimination Learning; Exercise | 2003 |
8 other studies available for lactic acid and Depressive Disorder, Major
Article | Year |
---|---|
HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
Topics: Affect; Animals; Depressive Disorder, Major; Glycogen Synthase Kinase 3 beta; Hippocampus; HSP70 Hea | 2023 |
The impact of lactic acid and medium chain triglyceride on blood glucose, lactate and diurnal motor activity: A re-examination of a treatment of major depression using lactic acid.
Topics: Animals; Blood Glucose; Circadian Rhythm; Depressive Disorder, Major; Dose-Response Relationship, Dr | 2019 |
Rocuronium-sugammadex decreases the severity of post-electroconvulsive therapy agitation.
Topics: Androstanols; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalography; gamma-C | 2013 |
Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
Topics: Adolescent; Aspartic Acid; Cerebral Ventricles; Cerebrospinal Fluid; Choline; Creatine; Depressive D | 2016 |
Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder.
Topics: Adult; Aspartic Acid; Brain; Depressive Disorder, Major; Energy Metabolism; Female; Glucose; Gyrus C | 2017 |
Peripheral administration of lactate produces antidepressant-like effects.
Topics: Animals; Antidepressive Agents; Astrocytes; Depression; Depressive Disorder, Major; Disease Models, | 2018 |
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.
Topics: Adult; Cerebral Ventricles; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Female; gamma-Ami | 2010 |
Parkinsonism and elevated lactic acid with sertraline.
Topics: Basal Ganglia; Depressive Disorder, Major; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; | 2005 |