Page last updated: 2024-10-17

lactic acid and Depressive Disorder, Major

lactic acid has been researched along with Depressive Disorder, Major in 9 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's6 (66.67)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Wang, J1
Lu, T1
Gui, Y1
Zhang, X1
Cao, X1
Li, Y1
Li, C1
Liu, L1
Ding, Z1
Murack, M1
Messier, C1
Postaci, A1
Tiryaki, C1
Sacan, O1
Ornek, D1
Kalyoncu, M1
Dikmen, B1
Bradley, KA1
Mao, X2
Case, JA1
Kang, G1
Shungu, DC2
Gabbay, V1
Ernst, J1
Hock, A1
Henning, A1
Seifritz, E1
Boeker, H1
Grimm, S1
Carrard, A1
Elsayed, M1
Margineanu, M1
Boury-Jamot, B1
Fragnière, L1
Meylan, EM1
Petit, JM1
Fiumelli, H1
Magistretti, PJ1
Martin, JL1
Murrough, JW1
Collins, KA1
Kelly, C1
Andrade, G1
Nestadt, P1
Levine, SM1
Mathew, SJ1
Kubesch, S1
Bretschneider, V1
Freudenmann, R1
Weidenhammer, N1
Lehmann, M1
Spitzer, M1
Grön, G1
Mendhekar, DN1
Benuiwal, RP1
Puri, V1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Impacts of Yoga and Aerobic Exercise on Neuro-cognitive Function and Symptoms in Early Psychosis - A Single-blind Randomized Controlled Clinical Trial[NCT01207219]140 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Attention and Concentration

"measured by Letter Cancellation test Q score. The basic version of the task consists of six 52-character rows in which the target character is randomly interspersed approximately 18 times in each row. Subjects were asked to cancel the letter C and E as quickly as possible. The time to completion, number of error and omission items were recorded. A quality of search index (Q), developed by Geldmacher et al., was applied for the analysis. Q is the ratio of correct number to total number of targets multiplied by the ratio of correct number per second. Higher Q scores represent more efficient performance and better attention and concentration. Q scores could range from 0 (worst possible outcome) to 1 (best possible outcome)." (NCT01207219)
Timeframe: baseline and 12 weeks

,,
InterventionCorrect number per second (Mean)
Baseline12 weeks
Aerobic Exercise0.710.77
Waitlist Control Group0.740.73
Yoga Therapy0.760.84

Severity of Symptoms

PANSS total score is computed by summing the scores of positive, negative and general symptom subscores. The range of PANSS total score is from 30 to 210, range of PANSS positive and negative subscores is from 7 to 49, range of PANSS general symptoms subscore is from 16 to 112, with higher values representing worse outcome. CDS total score is computed by summing the scores of nine items of the scale. The range of CDS total score is from 0 to 27, with higher values representing worse outcome. (NCT01207219)
Timeframe: Baseline and 12 weeks

,,
Interventionunits on a scale (Mean)
PANSS total score-BaselinePANSS total score-12 weeksPANSS positive subscore-BaselinePANSS positive subscore-12 weeksPANSS negative subscore-BaselinePANSS negative subscore-12 weeksPANSS general symptoms-BaselinePANSS general symptoms-12 weeksCDS-BaselineCDS-12 weeks
Aerobic Exercise46.839.59.78.311.29.725.921.63.41.7
Waitlist Control Group45.449.09.810.011.212.624.526.43.74.3
Yoga Therapy46.937.49.98.411.08.726.020.33.61.7

Verbal Acquisition

Total number of corrected encoded words in the first three trials in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks

,,
Interventioncorrectly encoded words (Mean)
Baseline12 weeks
Aerobic Exercise22.028.8
Waitlist Control Group22.724.8
Yoga Therapy22.829.5

Verbal Retention

The total number of correctly recalled words after short-term (10 minutes) and long-term (30 minutes) delay in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks

,,
Interventioncorrectly recorded words (Mean)
Baseline12 weeks
Aerobic Exercise15.121.0
Waitlist Control Group14.516.6
Yoga Therapy14.919.4

Working Memory

measured by Digit Span backwards test. In this test, the subject was asked to recall a series of numbers in reverse order. The correctly recalled series were scored as 1, and the test contains 14 sequences of numbers. The range of working memory score is from 0 to 14, with higher values representing better outcome. (NCT01207219)
Timeframe: baseline and 12 weeks

,,
InterventionScores on a scale (Mean)
Baseline12 weeks
Aerobic Exercise6.89.4
Waitlist Control Group7.17.7
Yoga Therapy6.88.5

Trials

1 trial available for lactic acid and Depressive Disorder, Major

ArticleYear
Aerobic endurance exercise improves executive functions in depressed patients.
    The Journal of clinical psychiatry, 2003, Volume: 64, Issue:9

    Topics: Adult; Attention; Cognition Disorders; Depressive Disorder, Major; Discrimination Learning; Exercise

2003

Other Studies

8 other studies available for lactic acid and Depressive Disorder, Major

ArticleYear
HSPA12A controls cerebral lactate homeostasis to maintain hippocampal neurogenesis and mood stabilization.
    Translational psychiatry, 2023, 08-14, Volume: 13, Issue:1

    Topics: Affect; Animals; Depressive Disorder, Major; Glycogen Synthase Kinase 3 beta; Hippocampus; HSP70 Hea

2023
The impact of lactic acid and medium chain triglyceride on blood glucose, lactate and diurnal motor activity: A re-examination of a treatment of major depression using lactic acid.
    Physiology & behavior, 2019, 09-01, Volume: 208

    Topics: Animals; Blood Glucose; Circadian Rhythm; Depressive Disorder, Major; Dose-Response Relationship, Dr

2019
Rocuronium-sugammadex decreases the severity of post-electroconvulsive therapy agitation.
    The journal of ECT, 2013, Volume: 29, Issue:1

    Topics: Androstanols; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalography; gamma-C

2013
Increased ventricular cerebrospinal fluid lactate in depressed adolescents.
    European psychiatry : the journal of the Association of European Psychiatrists, 2016, Volume: 32

    Topics: Adolescent; Aspartic Acid; Cerebral Ventricles; Cerebrospinal Fluid; Choline; Creatine; Depressive D

2016
Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder.
    Molecular psychiatry, 2017, Volume: 22, Issue:1

    Topics: Adult; Aspartic Acid; Brain; Depressive Disorder, Major; Energy Metabolism; Female; Glucose; Gyrus C

2017
Peripheral administration of lactate produces antidepressant-like effects.
    Molecular psychiatry, 2018, Volume: 23, Issue:2

    Topics: Animals; Antidepressive Agents; Astrocytes; Depression; Depressive Disorder, Major; Disease Models,

2018
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.
    NMR in biomedicine, 2010, Volume: 23, Issue:6

    Topics: Adult; Cerebral Ventricles; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Female; gamma-Ami

2010
Parkinsonism and elevated lactic acid with sertraline.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:5

    Topics: Basal Ganglia; Depressive Disorder, Major; Female; Humans; Lactic Acid; Magnetic Resonance Imaging;

2005