lactic acid has been researched along with Demyelinating Diseases in 16 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination." | 3.72 | Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003) |
| "Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments." | 1.48 | Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord. ( Alizadeh, A; Henrie, R; Karimi-Abdolrezaee, S; Kataria, H; Saboktakin Rizi, S; Santhosh, KT; Shahriary, GM; Thliveris, JA, 2018) |
| "Cuprizone induced demyelination in the corpus callosum and remyelination occurred after cuprizone treatment ceased." | 1.46 | Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation. ( Doi, T; Ichihara, Y; Nagao, M; Ogata, T; Ryu, Y; Sawada, Y, 2017) |
| "Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events." | 1.40 | Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014) |
| "Animals with a lateral demyelination lesion showed a reduction in CD68+ macrophages when treated with hirudin-loaded PLGA/F-127 gels compared to control and heparin-treated animals." | 1.40 | Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion. ( Horner, PJ; Kim, TH; Mount, CW; Pun, SH; Sellers, DL, 2014) |
| "Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult." | 1.37 | Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011) |
| "Tumefactive demyelination (TD) is a relatively uncommon entity which mimics other focal intracranial lesions." | 1.37 | Conventional and advanced magnetic resonance imaging in tumefactive demyelination. ( Chatterjee, S; Kesavadas, C; Saini, J; Thomas, B, 2011) |
| "Despite regional variability of demyelination, proton magnetic resonance spectroscopy revealed a specific metabolic pattern in all patients, with only moderate reduction of N-acetylaspartate, normal or reduced choline-containing compounds, normal or enhanced myo-inositol and no detectable lactate, which differs from findings in progressive cerebral adrenoleukodystrophy which usually exhibits a severe reduction of N-acetylaspartate and marked increases of choline-containing compounds, myo-inositol, and lactate." | 1.29 | Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients. ( Frahm, J; Hanefeld, F; Hunneman, DH; Jost, W; Korenke, GC; Krasemann, E; Pouwels, PJ; Stoeckler, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Jha, MK | 1 |
| Ament, XH | 1 |
| Yang, F | 1 |
| Liu, Y | 1 |
| Polydefkis, MJ | 1 |
| Pellerin, L | 1 |
| Morrison, BM | 1 |
| Kataria, H | 1 |
| Alizadeh, A | 1 |
| Shahriary, GM | 1 |
| Saboktakin Rizi, S | 1 |
| Henrie, R | 1 |
| Santhosh, KT | 1 |
| Thliveris, JA | 1 |
| Karimi-Abdolrezaee, S | 1 |
| Mori, Y | 1 |
| Murakami, M | 1 |
| Arima, Y | 1 |
| Zhu, D | 1 |
| Terayama, Y | 1 |
| Komai, Y | 1 |
| Nakatsuji, Y | 1 |
| Kamimura, D | 1 |
| Yoshioka, Y | 1 |
| Sellers, DL | 1 |
| Kim, TH | 1 |
| Mount, CW | 1 |
| Pun, SH | 1 |
| Horner, PJ | 1 |
| Ichihara, Y | 1 |
| Doi, T | 1 |
| Ryu, Y | 1 |
| Nagao, M | 1 |
| Sawada, Y | 1 |
| Ogata, T | 1 |
| Takenaka, S | 1 |
| Shinoda, J | 1 |
| Asano, Y | 1 |
| Aki, T | 1 |
| Miwa, K | 1 |
| Ito, T | 1 |
| Yokoyama, K | 1 |
| Iwama, T | 1 |
| Saini, J | 1 |
| Chatterjee, S | 1 |
| Thomas, B | 1 |
| Kesavadas, C | 1 |
| Fünfschilling, U | 1 |
| Supplie, LM | 1 |
| Mahad, D | 1 |
| Boretius, S | 1 |
| Saab, AS | 1 |
| Edgar, J | 1 |
| Brinkmann, BG | 1 |
| Kassmann, CM | 1 |
| Tzvetanova, ID | 1 |
| Möbius, W | 1 |
| Diaz, F | 1 |
| Meijer, D | 1 |
| Suter, U | 1 |
| Hamprecht, B | 1 |
| Sereda, MW | 1 |
| Moraes, CT | 1 |
| Frahm, J | 3 |
| Goebbels, S | 1 |
| Nave, KA | 1 |
| Gambini, A | 1 |
| Falini, A | 1 |
| Moiola, L | 1 |
| Comi, G | 1 |
| Scotti, G | 1 |
| Brockmann, K | 1 |
| Dechent, P | 1 |
| Meins, M | 1 |
| Haupt, M | 1 |
| Sperner, J | 1 |
| Stephani, U | 1 |
| Hanefeld, F | 2 |
| LOWENTHAL, A | 1 |
| VAN SANDE, M | 1 |
| KARCHER, D | 1 |
| Cianfoni, A | 1 |
| Niku, S | 1 |
| Imbesi, SG | 1 |
| Korenke, GC | 1 |
| Pouwels, PJ | 1 |
| Hunneman, DH | 1 |
| Stoeckler, S | 1 |
| Krasemann, E | 1 |
| Jost, W | 1 |
| Hedley-Whyte, ET | 1 |
| Arnold, DL | 1 |
| Matthews, PM | 1 |
| Francis, GS | 1 |
| O'Connor, J | 1 |
| Antel, JP | 1 |
| Marks, HG | 1 |
| Caro, PA | 1 |
| Wang, ZY | 1 |
| Detre, JA | 1 |
| Bogdan, AR | 1 |
| Gusnard, DA | 1 |
| Zimmerman, RA | 1 |
16 other studies available for lactic acid and Demyelinating Diseases
| Article | Year |
|---|---|
Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy.
Topics: Animals; Axons; Behavior, Animal; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic | 2020 |
Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord.
Topics: Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Demyelinating Diseases; Disease Models, | 2018 |
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.
Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis | 2014 |
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.
Topics: Animals; Antithrombins; Delayed-Action Preparations; Demyelinating Diseases; Fibrinolytic Agents; He | 2014 |
Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation.
Topics: Animals; Arabinose; Cell Cycle; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Co | 2017 |
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe | 2011 |
Conventional and advanced magnetic resonance imaging in tumefactive demyelination.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinatin | 2011 |
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
Topics: Action Potentials; Alkyl and Aryl Transferases; Animals; Axons; Brain; Cell Respiration; Cell Surviv | 2012 |
Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
Topics: Alcohol-Related Disorders; Atrophy; Choline; Corpus Callosum; Creatine; Demyelinating Diseases; Huma | 2003 |
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr | 2003 |
[Increase of the concentration of dehydrogenase of lactic acid and malic acid in the white substance in demyelinizing diseases].
Topics: Demyelinating Diseases; Humans; Lactic Acid; Malates; Multiple Sclerosis; Nervous System; Oxidoreduc | 1961 |
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; | 2007 |
Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients.
Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic; Child; Choline; Demyelinating Diseases; Female; Hum | 1996 |
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation.
Topics: Administration, Inhalation; Brain; Demyelinating Diseases; Heroin; Heroin Dependence; Humans; Hypoxi | 2000 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in Canavan's disease: a case report.
Topics: Amidohydrolases; Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain Diseases, Metabolic; Chi | 1991 |