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lactic acid and Demyelinating Diseases

lactic acid has been researched along with Demyelinating Diseases in 16 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.

Research Excerpts

ExcerptRelevanceReference
" Strongly elevated concentrations of myo-inositol in conjunction with normal or increased choline-containing compounds in all regions investigated point to astrocytosis and demyelination."3.72Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease. ( Brockmann, K; Dechent, P; Frahm, J; Hanefeld, F; Haupt, M; Meins, M; Sperner, J; Stephani, U, 2003)
"Oligodendroglial cell death and demyelination are hallmarks of neurotrauma and multiple sclerosis that cause axonal damage and functional impairments."1.48Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord. ( Alizadeh, A; Henrie, R; Karimi-Abdolrezaee, S; Kataria, H; Saboktakin Rizi, S; Santhosh, KT; Shahriary, GM; Thliveris, JA, 2018)
"Cuprizone induced demyelination in the corpus callosum and remyelination occurred after cuprizone treatment ceased."1.46Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation. ( Doi, T; Ichihara, Y; Nagao, M; Ogata, T; Ryu, Y; Sawada, Y, 2017)
"Additionally, demyelination regions of some MS patients had increased lactic acid content, suggesting the presence of ischemic events."1.40Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model. ( Arima, Y; Kamimura, D; Komai, Y; Mori, Y; Murakami, M; Nakatsuji, Y; Terayama, Y; Yoshioka, Y; Zhu, D, 2014)
"Animals with a lateral demyelination lesion showed a reduction in CD68+ macrophages when treated with hirudin-loaded PLGA/F-127 gels compared to control and heparin-treated animals."1.40Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion. ( Horner, PJ; Kim, TH; Mount, CW; Pun, SH; Sellers, DL, 2014)
"Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult."1.37Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011)
"Tumefactive demyelination (TD) is a relatively uncommon entity which mimics other focal intracranial lesions."1.37Conventional and advanced magnetic resonance imaging in tumefactive demyelination. ( Chatterjee, S; Kesavadas, C; Saini, J; Thomas, B, 2011)
"Despite regional variability of demyelination, proton magnetic resonance spectroscopy revealed a specific metabolic pattern in all patients, with only moderate reduction of N-acetylaspartate, normal or reduced choline-containing compounds, normal or enhanced myo-inositol and no detectable lactate, which differs from findings in progressive cerebral adrenoleukodystrophy which usually exhibits a severe reduction of N-acetylaspartate and marked increases of choline-containing compounds, myo-inositol, and lactate."1.29Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients. ( Frahm, J; Hanefeld, F; Hunneman, DH; Jost, W; Korenke, GC; Krasemann, E; Pouwels, PJ; Stoeckler, S, 1996)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's3 (18.75)18.2507
2000's4 (25.00)29.6817
2010's7 (43.75)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Jha, MK1
Ament, XH1
Yang, F1
Liu, Y1
Polydefkis, MJ1
Pellerin, L1
Morrison, BM1
Kataria, H1
Alizadeh, A1
Shahriary, GM1
Saboktakin Rizi, S1
Henrie, R1
Santhosh, KT1
Thliveris, JA1
Karimi-Abdolrezaee, S1
Mori, Y1
Murakami, M1
Arima, Y1
Zhu, D1
Terayama, Y1
Komai, Y1
Nakatsuji, Y1
Kamimura, D1
Yoshioka, Y1
Sellers, DL1
Kim, TH1
Mount, CW1
Pun, SH1
Horner, PJ1
Ichihara, Y1
Doi, T1
Ryu, Y1
Nagao, M1
Sawada, Y1
Ogata, T1
Takenaka, S1
Shinoda, J1
Asano, Y1
Aki, T1
Miwa, K1
Ito, T1
Yokoyama, K1
Iwama, T1
Saini, J1
Chatterjee, S1
Thomas, B1
Kesavadas, C1
Fünfschilling, U1
Supplie, LM1
Mahad, D1
Boretius, S1
Saab, AS1
Edgar, J1
Brinkmann, BG1
Kassmann, CM1
Tzvetanova, ID1
Möbius, W1
Diaz, F1
Meijer, D1
Suter, U1
Hamprecht, B1
Sereda, MW1
Moraes, CT1
Frahm, J3
Goebbels, S1
Nave, KA1
Gambini, A1
Falini, A1
Moiola, L1
Comi, G1
Scotti, G1
Brockmann, K1
Dechent, P1
Meins, M1
Haupt, M1
Sperner, J1
Stephani, U1
Hanefeld, F2
LOWENTHAL, A1
VAN SANDE, M1
KARCHER, D1
Cianfoni, A1
Niku, S1
Imbesi, SG1
Korenke, GC1
Pouwels, PJ1
Hunneman, DH1
Stoeckler, S1
Krasemann, E1
Jost, W1
Hedley-Whyte, ET1
Arnold, DL1
Matthews, PM1
Francis, GS1
O'Connor, J1
Antel, JP1
Marks, HG1
Caro, PA1
Wang, ZY1
Detre, JA1
Bogdan, AR1
Gusnard, DA1
Zimmerman, RA1

Other Studies

16 other studies available for lactic acid and Demyelinating Diseases

ArticleYear
Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy.
    Experimental neurology, 2020, Volume: 333

    Topics: Animals; Axons; Behavior, Animal; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic

2020
Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord.
    Glia, 2018, Volume: 66, Issue:3

    Topics: Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Demyelinating Diseases; Disease Models,

2018
Early pathological alterations of lower lumbar cords detected by ultrahigh-field MRI in a mouse multiple sclerosis model.
    International immunology, 2014, Volume: 26, Issue:2

    Topics: Angiography; Animals; Blood Vessels; Blood-Brain Barrier; Cell Movement; Demyelinating Diseases; Dis

2014
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.
    Biomaterials, 2014, Volume: 35, Issue:31

    Topics: Animals; Antithrombins; Delayed-Action Preparations; Demyelinating Diseases; Fibrinolytic Agents; He

2014
Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation.
    Journal of cellular physiology, 2017, Volume: 232, Issue:5

    Topics: Animals; Arabinose; Cell Cycle; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Co

2017
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
    Brain tumor pathology, 2011, Volume: 28, Issue:3

    Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe

2011
Conventional and advanced magnetic resonance imaging in tumefactive demyelination.
    Acta radiologica (Stockholm, Sweden : 1987), 2011, Dec-01, Volume: 52, Issue:10

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Mapping; Child; Choline; Contrast Media; Demyelinatin

2011
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity.
    Nature, 2012, Apr-29, Volume: 485, Issue:7399

    Topics: Action Potentials; Alkyl and Aryl Transferases; Animals; Axons; Brain; Cell Respiration; Cell Surviv

2012
Marchiafava-Bignami disease: longitudinal MR imaging and MR spectroscopy study.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:2

    Topics: Alcohol-Related Disorders; Atrophy; Choline; Corpus Callosum; Creatine; Demyelinating Diseases; Huma

2003
Cerebral proton magnetic resonance spectroscopy in infantile Alexander disease.
    Journal of neurology, 2003, Volume: 250, Issue:3

    Topics: Alexander Disease; Aspartic Acid; Brain; Child; Child, Preschool; Demyelinating Diseases; Disease Pr

2003
[Increase of the concentration of dehydrogenase of lactic acid and malic acid in the white substance in demyelinizing diseases].
    Acta neurologica et psychiatrica Belgica, 1961, Volume: 61

    Topics: Demyelinating Diseases; Humans; Lactic Acid; Malates; Multiple Sclerosis; Nervous System; Oxidoreduc

1961
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
    AJNR. American journal of neuroradiology, 2007, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases;

2007
Arrested cerebral adrenoleukodystrophy: a clinical and proton magnetic resonance spectroscopy study in three patients.
    Pediatric neurology, 1996, Volume: 15, Issue:2

    Topics: Aspartic Acid; Brain; Brain Diseases, Metabolic; Child; Choline; Demyelinating Diseases; Female; Hum

1996
Leukoencephalopathy and raised brain lactate from heroin vapor inhalation.
    Neurology, 2000, May-23, Volume: 54, Issue:10

    Topics: Administration, Inhalation; Brain; Demyelinating Diseases; Heroin; Heroin Dependence; Humans; Hypoxi

2000
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
    Annals of neurology, 1992, Volume: 31, Issue:3

    Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De

1992
Use of computed tomography, magnetic resonance imaging, and localized 1H magnetic resonance spectroscopy in Canavan's disease: a case report.
    Annals of neurology, 1991, Volume: 30, Issue:1

    Topics: Amidohydrolases; Amino Acid Metabolism, Inborn Errors; Aspartic Acid; Brain Diseases, Metabolic; Chi

1991