Compounds > lactic acid
Page last updated: 2024-10-17

lactic acid and Deficiency, Thiamine

lactic acid has been researched along with Deficiency, Thiamine in 30 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Hypophosphatemia may be a useful biomarker to identify thiamine deficiency in critically ill enterally-fed patients."9.41A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). ( Ali Abdelhamid, Y; Bellomo, R; Byrne, KM; Clancy, A; Collie, JT; Deane, AM; Douglas, JS; Fetterplace, K; Finnis, ME; Fujii, T; Greaves, R; Jiang, A; Maiden, MJ; Nichol, A; Plummer, MP; Russo, G; Tascone, B; Udy, AA; Yanase, F; Young, M, 2021)
"Gastric beriberi is a rare presentation of TD that can lead to severe GI symptoms and lactic acidosis."8.12Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi. ( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
"Thiamine functions as an important cofactor in aerobic metabolism and thiamine deficiency can contribute to lactic acidosis."7.80The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. ( Berg, K; Donnino, MW; Gautam, S; Giberson, T; Graver, A; Liu, X; Moskowitz, A; Uber, A, 2014)
"A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage."7.80Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014)
"An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN)."7.72Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. ( Calvillo, M; Caruso, U; Dufour, C; Minniti, G; Schiaffino, MC; Svahn, J, 2003)
"Two patients aged 37 and 44 years developed life-threatening lactic acidosis following abdominal surgery and a period of about 3 weeks of total parenteral nutrition."7.68[Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition]. ( Asskali, F; Behne, M; Kessler, P; Klein, G; Lorenz, M; Probst, S; Steuer, A, 1991)
"Two patients, both with short bowel syndrome, presented with severe D-lactic acidosis associated with subacute small bowel obstruction and bizarre neurological signs."7.68D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms. ( Hudson, M; Mowat, NA; Pocknee, R, 1990)
"Hypophosphatemia may be a useful biomarker to identify thiamine deficiency in critically ill enterally-fed patients."5.41A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). ( Ali Abdelhamid, Y; Bellomo, R; Byrne, KM; Clancy, A; Collie, JT; Deane, AM; Douglas, JS; Fetterplace, K; Finnis, ME; Fujii, T; Greaves, R; Jiang, A; Maiden, MJ; Nichol, A; Plummer, MP; Russo, G; Tascone, B; Udy, AA; Yanase, F; Young, M, 2021)
"Gastric beriberi is a rare presentation of TD that can lead to severe GI symptoms and lactic acidosis."4.12Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi. ( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
"Thiamine functions as an important cofactor in aerobic metabolism and thiamine deficiency can contribute to lactic acidosis."3.80The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. ( Berg, K; Donnino, MW; Gautam, S; Giberson, T; Graver, A; Liu, X; Moskowitz, A; Uber, A, 2014)
"A 16-year-old perioperative paediatric patient presented with refractory lactic acidosis and multiorgan failure due to thiamine-deficient total parenteral nutrition during a recent national multivitamin shortage."3.80Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition. ( Hartman, G; Mowbray, C; Pageler, N; Ramsi, M, 2014)
" In conclusion, no thiamine deficiency was noted in patients with normal anion gap, but thiamine deficiency was not uncommon in patients with a wide anion gap, regardless of lactic acidosis."3.74A preliminary study of thiamine status in northeastern Thai children with acute diarrhea. ( Boonsiri, P; Panthongviriyakul, C; Tangrassameeprasert, R; Yongvanit, P, 2007)
"Long-term thiamine deficiency has been largely documented, whilst little is known about effects of short-term depletion/repletion periods on thiamine vitamers status."3.74Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model. ( Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA, 2007)
"An 11-month-old girl with B-cell leukemia/lymphoma developed profound lethargy due to severe lactic acidosis during chemotherapy and total parenteral nutrition (TPN)."3.72Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy. ( Calvillo, M; Caruso, U; Dufour, C; Minniti, G; Schiaffino, MC; Svahn, J, 2003)
"Two patients aged 37 and 44 years developed life-threatening lactic acidosis following abdominal surgery and a period of about 3 weeks of total parenteral nutrition."3.68[Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition]. ( Asskali, F; Behne, M; Kessler, P; Klein, G; Lorenz, M; Probst, S; Steuer, A, 1991)
"Two patients, both with short bowel syndrome, presented with severe D-lactic acidosis associated with subacute small bowel obstruction and bizarre neurological signs."3.68D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms. ( Hudson, M; Mowat, NA; Pocknee, R, 1990)
"Adult patients with septic shock and elevated (> 3 mmol/L) lactate between 2010 and 2014."2.82Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study. ( Andersen, LW; Berg, KM; Chase, M; Cocchi, MN; Donnino, MW; Giberson, T; Moskowitz, A; Ngo, L; Smithline, H; Tidswell, M; Wolfe, R, 2016)
"Pyrithiamine treatment in low thiamine medium (M199) for 7 days caused cytotoxic effects on RBE4 cells at all concentrations (10-50 microg/ml)."1.30Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells. ( Abbott, NJ; Aleshaiker, A; Rist, RJ; Romero, IA, 1997)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19907 (23.33)18.7374
1990's5 (16.67)18.2507
2000's4 (13.33)29.6817
2010's9 (30.00)24.3611
2020's5 (16.67)2.80

Authors

AuthorsStudies
Nisar, S1
Tanvir, M1
Ganie, MA1
Kareem, O1
Muzaffer, U1
Wani, IA1
Chehayeb, RJ1
Ilagan-Ying, YC1
Sankey, C1
Wardi, G1
Brice, J1
Correia, M1
Liu, D1
Self, M1
Tainter, C1
Song, JH1
Jung, DI1
Deane, AM1
Jiang, A1
Tascone, B1
Clancy, A1
Finnis, ME1
Collie, JT1
Greaves, R1
Byrne, KM1
Fujii, T1
Douglas, JS1
Nichol, A1
Udy, AA1
Young, M1
Russo, G1
Fetterplace, K1
Maiden, MJ1
Plummer, MP1
Yanase, F1
Bellomo, R1
Ali Abdelhamid, Y1
Souki, FG1
Ghaffaripour, S1
Martinez-Lu, K1
Mahmoudi, H1
Ricci, Z1
Romagnoli, S1
Zera, K1
Zastre, J1
Patel, JJ1
Bergl, P1
Moskowitz, A2
Graver, A1
Giberson, T2
Berg, K1
Liu, X1
Uber, A1
Gautam, S1
Donnino, MW2
Sweet, RL1
Zastre, JA1
Ramsi, M1
Mowbray, C1
Hartman, G1
Pageler, N1
Andersen, LW1
Chase, M1
Berg, KM1
Tidswell, M1
Wolfe, R1
Smithline, H1
Ngo, L1
Cocchi, MN1
Boonsiri, P1
Tangrassameeprasert, R1
Panthongviriyakul, C1
Yongvanit, P1
Jankowska-Kulawy, A1
Bielarczyk, H1
Pawełczyk, T1
Wróblewska, M1
Szutowicz, A1
Jones, JH1
De Angeli, E1
Svahn, J1
Schiaffino, MC1
Caruso, U1
Calvillo, M1
Minniti, G1
Dufour, C1
Ham, D1
Karska-Wysocki, B1
Batifoulier, F1
Verny, MA1
Besson, C1
Chanliaud, E1
Rémésy, C1
Demigné, C1
Gorbach, ZV1
Maglysh, SS1
Ostrovskiĭ, IuM1
Schwartau, M2
Doehn, M2
Jürgens, P1
Lubek, BM1
Mainwood, GW1
McCandless, DW1
Munujos, P1
Coll-Cantí, J1
Beleta, J1
González-Sastre, F1
Gella, FJ1
Romero, IA1
Rist, RJ1
Aleshaiker, A1
Abbott, NJ1
Lange, R1
Erhard, J1
Eigler, FW1
Roll, C1
Klein, G1
Probst, S1
Kessler, P1
Behne, M1
Asskali, F1
Steuer, A1
Lorenz, M1
Hudson, M1
Pocknee, R1
Mowat, NA1
van der Beek, EJ1
van Dokkum, W1
Schrijver, J1
Wedel, M1
Gaillard, AW1
Wesstra, A1
van de Weerd, H1
Hermus, RJ1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718]80 participants (Anticipated)Observational2023-09-30Not yet recruiting
The Thiamine Administration After Cardiac Surgery Trial[NCT04641104]Phase 4200 participants (Actual)Interventional2020-11-20Completed
Thiamine as a Renal Protective Agent in Septic Shock: A Randomized, Controlled Study[NCT03550794]Phase 295 participants (Actual)Interventional2018-09-04Completed
Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock[NCT03380507]Phase 2/Phase 3106 participants (Actual)Interventional2018-03-17Terminated (stopped due to The research is no longer funded and terminated due to futility)
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]Phase 2140 participants (Actual)Interventional2018-02-05Completed
Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555]Phase 2/Phase 3205 participants (Actual)Interventional2018-02-09Completed
Combination Therapy of Vitamin C and Thiamine for Septic Shock: Multi-center, Double-blinded, Randomized, Controlled Study[NCT03756220]Phase 2116 participants (Actual)Interventional2018-12-01Completed
A Randomized, Double Blind, Placebo-Controlled Study to Investigate the Effects of Vitamin C, Hydrocortisone and Thiamine on the Outcome of Patients With Severe Sepsis and Septic Shock[NCT03335124]Phase 45 participants (Actual)Interventional2017-09-26Terminated (stopped due to Due to insufficient recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Lactate Level

Change in lactate level between enrollment and 72 hours after enrollment (NCT03550794)
Timeframe: From time of enrollment until 72 hours after enrollment

Interventionmmol/L (Median)
Thiamine1.65
Placebo1.95

Change in the Sequential Organ Failure Assessment Score

Change in Sequential Organ Failure Assessment Score (SOFA) score between enrollment and 72 hours after enrollment. SOFA scores are reported on a scale between 0-24, with 0 representing best outcome and 24 representing worst outcome. (NCT03550794)
Timeframe: Time of enrollment until 72 hours after enrollment

Interventionunits on a scale (Mean)
Thiamine8.09
Placebo9.61

ICU Free Days

Days alive and free of the ICU through day 28 (NCT03550794)
Timeframe: From date of enrollment until 28 days after enrollment

Interventiondays (Median)
Thiamine22.5
Placebo0.0

In-hospital Mortality

Length of hospital stay truncated at 60 days (NCT03550794)
Timeframe: From date of enrollment until discharge from the hospital or date of death, whichever comes first, up to 60 days after enrollment

InterventionParticipants (Count of Participants)
Thiamine15
Placebo25

Kidney Injury Biomarker

Change in creatinine over time (NCT03550794)
Timeframe: Enrollment to 72-hours

Interventionmg/dL (Mean)
Thiamine2.24
Placebo2.79

Number of Participants Experiences Acute Renal Failure

Acute renal failure as defined by the KDIGO (Kidney Disease Improving Global Outcomes) AKI (Acute Kidney Injury) criteria. In brief, a patient can meet these criteria if their serum creatinine increases (for example, serum creatinine increases to 1.5x or higher of baseline serum creatinine, or if it crosses 4mg/dL), or if renal replacement therapy is initiated, or if urine output decreases (for example, <0.5ml/kg/hour for 6-12 hours) or if patient becomes anuric (no urine production). (NCT03550794)
Timeframe: From date of enrollment until day of discharge from the index ICU admission or date of death, whichever comes first up until 60 days post-enrollment

InterventionParticipants (Count of Participants)
Thiamine23
Placebo34

Number of Participants Receiving Renal Replacement Therapy

Number of participants who received renal replacement therapy in thiamine and placebo groups. (NCT03550794)
Timeframe: From date of enrollment until discharge from the intensive care unit (ICU) or date of death, whichever comes first, up to 60 days after enrollment

InterventionParticipants (Count of Participants)
Thiamine6
Placebo10

Number of Participants With Delirium on Day 3

Number of Participants with Delirium on Day 3 after enrollment (NCT03550794)
Timeframe: Day 3 after enrollment

InterventionParticipants (Count of Participants)
Thiamine25
Placebo30

Novel Biomarkers of Renal Injury

KIM-1, NGAL, Cystatin-C at 24-hours after enrollment (NCT03550794)
Timeframe: 24 hours after enrollment

,
Interventionpg/mL (Median)
KIM-1NGALCystatin
Placebo793.91558285.02183175.4
Thiamine763.11067898.21689158.2

Change in Sequential Organ Failure Assessment (SOFA) Score

Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization

Interventionscore on a scale (Mean)
Treatment Arm2.9
Placebo Arm1.93

Hospital Length of Stay

Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.

InterventionDays (Mean)
Treatment Arm11.5
Placebo Arm11

Hospital Mortality

In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm11
Placebo Arm13

ICU Length of Stay

Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.

Interventiondays (Mean)
Treatment Arm4.76
Placebo Arm4.66

ICU Mortality

ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm6
Placebo Arm10

Procalcitonin (PCT) Clearance

PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization

InterventionPercent (Mean)
Treatment Arm63
Placebo Arm58

Time to Vasopressor Independence (Hours)

Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.

Interventionhours (Mean)
HAT Treatment27
Comparator53

Ventilator Free Days

Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization

InterventionDays (Mean)
Treatment Arm22
Placebo Arm22.4

30-day Mortality

Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids35
Placebo29

Hospital Disposition: Survivors Discharged Home

Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids34
Placebo35

Hospital Mortality

Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids28
Placebo23

ICU Free Days

Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids22
Placebo21

Intensive Care Unit (ICU) Mortality

ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids23
Placebo20

Number of Participants With Delirium

"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids31
Placebo35

Renal Failure

"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids32
Placebo27

Shock Free Days

Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids5
Placebo4

Ventilator Free Days

Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids6
Placebo6

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours

,
InterventionUnits on a scale (Mean)
Enrollment SOFA score72 hour SOFA score
Placebo9.25.1
Vitamin C, Vitamin B1, Corticosteroids9.14.4

Reviews

1 review available for lactic acid and Deficiency, Thiamine

ArticleYear
Demystifying Lactate in the Emergency Department.
    Annals of emergency medicine, 2020, Volume: 75, Issue:2

    Topics: Acidosis, Lactic; Emergency Service, Hospital; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Seps

2020

Trials

3 trials available for lactic acid and Deficiency, Thiamine

ArticleYear
A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial).
    Clinical nutrition (Edinburgh, Scotland), 2021, Volume: 40, Issue:8

    Topics: Administration, Intravenous; Adult; Aged; Biomarkers; Critical Illness; Enteral Nutrition; Female; H

2021
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study.
    Critical care medicine, 2016, Volume: 44, Issue:2

    Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pilot

2016
Thiamin, riboflavin, and vitamins B-6 and C: impact of combined restricted intake on functional performance in man.
    The American journal of clinical nutrition, 1988, Volume: 48, Issue:6

    Topics: Adult; Ascorbic Acid Deficiency; Body Composition; Double-Blind Method; Humans; Lactates; Lactic Aci

1988

Other Studies

26 other studies available for lactic acid and Deficiency, Thiamine

ArticleYear
Clinical profile of patients presenting with thiamine-responsive upper-gastrointestinal upset: A pointer toward gastric beriberi.
    Nutrition (Burbank, Los Angeles County, Calif.), 2022, Volume: 102

    Topics: Adult; Aged; Beriberi; Gastrointestinal Diseases; Humans; Lactic Acid; Middle Aged; Nausea; Thiamine

2022
Addressing Cognitive Biases in Interpreting an Elevated Lactate in a Patient with Type 1 Diabetes and Thiamine Deficiency.
    Journal of general internal medicine, 2023, Volume: 38, Issue:6

    Topics: Beriberi; Bias; Cognition; COVID-19; Diabetes Mellitus, Type 1; Female; Humans; Lactic Acid; Pandemi

2023
Thiamine deficiency in a dog associated with exclusive consumption of boiled sweet potato (Ipomoea batatas): Serial changes in clinical findings, magnetic resonance imaging findings and blood lactate and thiamine concentrations.
    Veterinary medicine and science, 2021, Volume: 7, Issue:1

    Topics: Animal Feed; Animals; Dog Diseases; Dogs; Ipomoea batatas; Lactic Acid; Magnetic Resonance Imaging;

2021
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation.
    Journal of clinical anesthesia, 2018, Volume: 44

    Topics: Acidosis, Lactic; Blood Glucose; Hemofiltration; Humans; Hyperglycemia; Insulin; Kidney Failure, Chr

2018
The 11th pitfall: thiamine deficiency.
    Intensive care medicine, 2018, Volume: 44, Issue:9

    Topics: Humans; Lactic Acid; Sepsis; Thiamine Deficiency

2018
Stabilization of the hypoxia-inducible transcription Factor-1 alpha (HIF-1α) in thiamine deficiency is mediated by pyruvate accumulation.
    Toxicology and applied pharmacology, 2018, 09-15, Volume: 355

    Topics: Animals; Astrocytes; Enzyme Inhibitors; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Ac

2018
Thiamine and Difficulties in Differentiating Type A From B Lactic Acidosis.
    Critical care medicine, 2019, Volume: 47, Issue:5

    Topics: Acidosis, Lactic; Humans; Lactic Acid; Shock, Septic; Thiamine; Thiamine Deficiency

2019
The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis.
    Journal of critical care, 2014, Volume: 29, Issue:1

    Topics: Acidosis, Lactic; Adult; Comorbidity; Diabetic Ketoacidosis; Female; Humans; Lactic Acid; Male; Midd

2014
HIF1-α-mediated gene expression induced by vitamin B1 deficiency.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2013, Volume: 83, Issue:3

    Topics: Cell Hypoxia; Cell Nucleus; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Lactic Acid;

2013
Severe lactic acidosis and multiorgan failure due to thiamine deficiency during total parenteral nutrition.
    BMJ case reports, 2014, Jun-03, Volume: 2014

    Topics: Acidosis, Lactic; Adolescent; Diagnosis, Differential; Humans; Hydrogen-Ion Concentration; Lactic Ac

2014
A preliminary study of thiamine status in northeastern Thai children with acute diarrhea.
    The Southeast Asian journal of tropical medicine and public health, 2007, Volume: 38, Issue:6

    Topics: Acidosis, Lactic; Acute Disease; Case-Control Studies; Child; Child, Preschool; Diarrhea; Female; Hu

2007
Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain.
    Journal of neurochemistry, 2010, Volume: 115, Issue:2

    Topics: Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Citric Acid; Ketoglutarate Dehydrogenase Complex;

2010
Thiamine deficiency and the in vivo oxidation of lactate and pyruvate labeled with carbon.
    The Journal of nutrition, 1960, Volume: 70

    Topics: Carbon; Lactates; Lactic Acid; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Thiamine; Thiamine Defi

1960
Severe lactic acidosis due to thiamine deficiency in a patient with B-cell leukemia/lymphoma on total parenteral nutrition during high-dose methotrexate therapy.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:12

    Topics: Acidosis, Lactic; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Lactic Acid; Leukemi

2003
Energy and glucose pathways in thiamine deficient primary rat brain microvascular endothelial cells.
    General physiology and biophysics, 2005, Volume: 24, Issue:4

    Topics: Animals; Brain; Cells, Cultured; Endothelial Cells; Energy Metabolism; Glucose; Lactic Acid; Microci

2005
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:1

    Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidne

2007
[Peculiarities of carbohydrate metabolism in the rat liver due to the limited accessibility of thiamine].
    Biokhimiia (Moscow, Russia), 1983, Volume: 48, Issue:11

    Topics: Adenine Nucleotides; Animals; Carbohydrate Metabolism; Cyclic AMP; L-Lactate Dehydrogenase; Lactates

1983
[Animal experiment studies of chronic thiamine deficiency. Changes in carbohydrate and amino acid metabolism under resting and load conditions].
    Zeitschrift fur Ernahrungswissenschaft, 1984, Volume: 23, Issue:3

    Topics: Amino Acids; Animals; Bicarbonates; Carbohydrates; Carbon Dioxide; Hydrogen-Ion Concentration; Lacta

1984
Lactate and pyruvate production in isolated thiamine-deficient rat diaphragm strips.
    Canadian journal of physiology and pharmacology, 1984, Volume: 62, Issue:3

    Topics: Animals; Diaphragm; Fatigue; Glucose; Glycolysis; Hydrogen; Hypoxia; In Vitro Techniques; Lactates;

1984
Energy metabolism in the lateral vestibular nucleus in pyrithiamin-induced thiamin deficiency.
    Annals of the New York Academy of Sciences, 1982, Volume: 378

    Topics: Adenosine Triphosphate; Animals; Diet; Energy Metabolism; Female; Glucose; Glycogen; Lactates; Lacti

1982
[Metabolic acidosis caused by thiamine-deficiency (author's transl)].
    Der Anaesthesist, 1981, Volume: 30, Issue:9

    Topics: Acidosis; Animals; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Physical Exertion; Rats;

1981
Brain pyruvate oxidation in experimental thiamin-deficiency encephalopathy.
    Clinica chimica acta; international journal of clinical chemistry, 1996, Nov-15, Volume: 255, Issue:1

    Topics: Alcohol Amnestic Disorder; Animals; Brain; Brain Chemistry; Female; Hypothalamus; Ketoglutarate Dehy

1996
Metabolic and permeability changes caused by thiamine deficiency in immortalized rat brain microvessel endothelial cells.
    Brain research, 1997, May-09, Volume: 756, Issue:1-2

    Topics: Actins; Animals; Antimetabolites; Blood Vessels; Capillary Permeability; Cell Line, Transformed; Cyt

1997
Lactic acidosis from thiamine deficiency during parenteral nutrition in a two-year-old boy.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 1992, Volume: 2, Issue:4

    Topics: Acidosis, Lactic; Child, Preschool; Humans; Intestinal Atresia; Jejunum; Lactates; Lactic Acid; Male

1992
[Thiamine deficiency as a cause of life threatening lactic acidosis in total parenteral nutrition].
    Klinische Wochenschrift, 1991, Volume: 69 Suppl 26

    Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Cholecystectomy; Choledochostomy; Colostomy; Critica

1991
D-lactic acidosis in short bowel syndrome--an examination of possible mechanisms.
    The Quarterly journal of medicine, 1990, Volume: 74, Issue:274

    Topics: Acidosis, Lactic; Adult; Blood Glucose; Female; Humans; Isomerism; Lactates; Lactic Acid; Malabsorpt

1990