lactic acid has been researched along with Deficiency, Mental in 13 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Biochemically, beta-ketothiolase deficiency is characterized by intermittent ketoacidosis and urinary excretion of 2-methyl-acetoacetate (MAA), 2-methyl-3-hydroxybutyrate (MHB) and tiglylglycine (TG), whereas in MHBD deficiency only MHB and tiglylglycine accumulate." | 3.73 | Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats. ( da C Ferreira, G; Dalcin, KB; de Assis, DR; Filho, CS; Latini, A; Leipnitz, G; Maria, RC; Perry, ML; Ribeiro, CA; Rosa, RB; Schuck, PF; Wajner, M; Wannmacher, CM; Wyse, AT, 2005) |
| "Propionic acidemia is the result of a deficiency in propionyl-CoA carboxylase activity." | 1.48 | Autism spectrum disorders in propionic acidemia patients. ( Arnoux, JB; Barbier, V; Bonnefont, JP; Brassier, A; Canouï, P; de la Bâtie, CD; De Lonlay, P; Gobin, S; Guemann, AS; Habarou, F; Lacaille, F; Ottolenghi, C; Ouss, L; Pontoizeau, C; Roda, C; Valayannopoulos, V, 2018) |
| "Epilepsy was present in 19 patients." | 1.33 | Mitochondrial dysfunction in autism spectrum disorders: a population-based study. ( Ataíde, A; Borges, L; Diogo, L; Garcia, P; Grazina, M; Marques, C; Miguel, T; Oliveira, CR; Oliveira, G; Vicente, AM, 2005) |
| "At age 3(1/2) years she has profound mental retardation, spasticity, and grand mal and myoclonic seizures only partially controlled by anticonvulsants." | 1.30 | Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate. ( Ahmad, A; Artigas-Lopez, M; Kahler, SG; Kishnani, PS; Millington, DS; Pappu, AS; Steiner, R; Van Hove, JL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de la Bâtie, CD | 1 |
| Barbier, V | 1 |
| Roda, C | 1 |
| Brassier, A | 1 |
| Arnoux, JB | 1 |
| Valayannopoulos, V | 1 |
| Guemann, AS | 1 |
| Pontoizeau, C | 1 |
| Gobin, S | 1 |
| Habarou, F | 1 |
| Lacaille, F | 1 |
| Bonnefont, JP | 1 |
| Canouï, P | 1 |
| Ottolenghi, C | 1 |
| De Lonlay, P | 1 |
| Ouss, L | 1 |
| Vissing, J | 1 |
| Akman, HO | 1 |
| Aasly, J | 1 |
| Kahler, SG | 2 |
| Bacino, CA | 1 |
| DiMauro, S | 1 |
| Haller, RG | 1 |
| Cassandrini, D | 1 |
| Cilio, MR | 1 |
| Bianchi, M | 1 |
| Doimo, M | 1 |
| Balestri, M | 1 |
| Tessa, A | 1 |
| Rizza, T | 1 |
| Sartori, G | 1 |
| Meschini, MC | 1 |
| Nesti, C | 1 |
| Tozzi, G | 1 |
| Petruzzella, V | 1 |
| Piemonte, F | 1 |
| Bisceglia, L | 1 |
| Bruno, C | 1 |
| Dionisi-Vici, C | 1 |
| D'Amico, A | 1 |
| Fattori, F | 1 |
| Carrozzo, R | 1 |
| Salviati, L | 1 |
| Santorelli, FM | 1 |
| Bertini, E | 1 |
| ISRAELS, S | 1 |
| HAWORTH, JC | 1 |
| GOURLEY, B | 1 |
| FORD, JD | 1 |
| Overweg-Plandsoen, WC | 1 |
| Groener, JE | 1 |
| Wang, D | 1 |
| Onkenhout, W | 1 |
| Brouwer, OF | 1 |
| Bakker, HD | 1 |
| De Vivo, DC | 1 |
| PRESCOTT, BA | 1 |
| BOREK, E | 1 |
| Oliveira, G | 1 |
| Diogo, L | 1 |
| Grazina, M | 1 |
| Garcia, P | 1 |
| Ataíde, A | 1 |
| Marques, C | 1 |
| Miguel, T | 1 |
| Borges, L | 1 |
| Vicente, AM | 1 |
| Oliveira, CR | 1 |
| Rosa, RB | 1 |
| Schuck, PF | 1 |
| de Assis, DR | 1 |
| Latini, A | 1 |
| Dalcin, KB | 1 |
| Ribeiro, CA | 1 |
| da C Ferreira, G | 1 |
| Maria, RC | 1 |
| Leipnitz, G | 1 |
| Perry, ML | 1 |
| Filho, CS | 1 |
| Wyse, AT | 1 |
| Wannmacher, CM | 1 |
| Wajner, M | 1 |
| Cheung, PY | 1 |
| Chui, N | 1 |
| Joffe, AR | 1 |
| Rebeyka, IM | 1 |
| Robertson, CM | 1 |
| Tsuchiyama, A | 1 |
| Oyanagi, K | 1 |
| Sogawa, H | 1 |
| Nakao, T | 1 |
| Ogawa, K | 1 |
| Fujita, S | 1 |
| Ahmad, A | 1 |
| Kishnani, PS | 1 |
| Artigas-Lopez, M | 1 |
| Pappu, AS | 1 |
| Steiner, R | 1 |
| Millington, DS | 1 |
| Van Hove, JL | 1 |
| Haas, RH | 1 |
| Rice, MA | 1 |
| Trauner, DA | 1 |
| Merritt, TA | 1 |
| Kobayashi, M | 1 |
| Morishita, H | 1 |
| Sugiyama, N | 1 |
| Yokochi, K | 1 |
| Nakano, M | 1 |
| Wada, Y | 1 |
| Hotta, Y | 1 |
| Terauchi, A | 1 |
| Nonaka, I | 1 |
13 other studies available for lactic acid and Deficiency, Mental
| Article | Year |
|---|---|
Autism spectrum disorders in propionic acidemia patients.
Topics: Adolescent; Adult; Autism Spectrum Disorder; Child; Child, Preschool; Female; Humans; Intellectual D | 2018 |
Level of residual enzyme activity modulates the phenotype in phosphoglycerate kinase deficiency.
Topics: Ergometry; Exercise Test; Exercise Tolerance; Genetic Diseases, X-Linked; Humans; Intellectual Disab | 2018 |
Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients.
Topics: Arginine-tRNA Ligase; Cerebellum; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infan | 2013 |
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism | 1964 |
GLUT-1 deficiency without epilepsy--an exceptional case.
Topics: Ataxia; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Child; DNA; DNA Mutational Analysis; | 2003 |
Studies on oligophrenia phenylpyruvica; microbiological determination of L- and D-phenylalanine and of phenyl lactic acid.
Topics: Acids; Body Fluids; Intellectual Disability; Lactic Acid; Phenylalanine; Phenylketonurias; Urine | 1949 |
Mitochondrial dysfunction in autism spectrum disorders: a population-based study.
Topics: Adolescent; Autistic Disorder; Child; Comorbidity; Cross-Sectional Studies; Epilepsy; Female; Humans | 2005 |
Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetates; Acetoacetates; Acetyl-CoA C-Acyltransferase; Acidosis; A | 2005 |
Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months.
Topics: Biomarkers; Blindness; Cardiac Surgical Procedures; Cerebral Palsy; Child Development; Cohort Studie | 2005 |
Normal activities of hepatic pyruvate dehydrogenase and pyruvate carboxylase in Leigh's syndrome.
Topics: Brain; Brain Stem; Central Nervous System Diseases; Encephalomalacia; Humans; Infant; Intellectual D | 1983 |
Treatment of pyruvate carboxylase deficiency with high doses of citrate and aspartate.
Topics: Amino Acids; Aspartic Acid; Child, Preschool; Citric Acid; Dose-Response Relationship, Drug; Female; | 1999 |
Therapeutic effects of a ketogenic diet in Rett syndrome.
Topics: Ammonia; Blood Glucose; Child; Child, Preschool; Dietary Fats; Electroencephalography; Energy Intake | 1986 |
Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome and NADH-CoQ reductase deficiency.
Topics: Acidosis; Adolescent; Cerebrovascular Disorders; Child, Preschool; Humans; Intellectual Disability; | 1986 |