lactic acid has been researched along with Cystic Fibrosis in 32 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " DoE was employed for optimization of ciprofloxacin loaded PLGA NPs for pulmonary delivery against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lungs." | 7.83 | Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach. ( Günday Türeli, N; Schneider, M; Türeli, AE, 2016) |
| " In this work, poly lactic-co-glycolic acid (PLGA) nanoparticles encapsulating curcumin were synthesized and used to treat two different CF mouse strains in an effort to correct the defects associated with CF by improving bioavailability of the compound, which has previously been a challenge in treatment with curcumin." | 5.36 | Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. ( Caplan, MJ; Caputo, C; Cartiera, MS; Egan, ME; Ferreira, EC; Saltzman, WM, 2010) |
| " DoE was employed for optimization of ciprofloxacin loaded PLGA NPs for pulmonary delivery against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lungs." | 3.83 | Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach. ( Günday Türeli, N; Schneider, M; Türeli, AE, 2016) |
| "Symptom scores of perceived breathlessness and muscle effort were recorded using Borg scales." | 2.71 | Symptoms, lactate and exercise limitation at peak cycle ergometry in adults with cystic fibrosis. ( Dodd, ME; Moorcroft, AJ; Morris, J; Webb, AK, 2005) |
| " In this work, poly lactic-co-glycolic acid (PLGA) nanoparticles encapsulating curcumin were synthesized and used to treat two different CF mouse strains in an effort to correct the defects associated with CF by improving bioavailability of the compound, which has previously been a challenge in treatment with curcumin." | 1.36 | Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. ( Caplan, MJ; Caputo, C; Cartiera, MS; Egan, ME; Ferreira, EC; Saltzman, WM, 2010) |
| " This may be minimized by the use of slow-release gene transfer preparations with more prolonged expression and longer dosing intervals for the patient." | 1.32 | Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo. ( Alton, EW; Geddes, DM; Stern, M; Ulrich, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 16 (50.00) | 24.3611 |
| 2020's | 6 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Jensen, PØ | 3 |
| Nielsen, BU | 2 |
| Kolpen, M | 2 |
| Pressler, T | 2 |
| Faurholt-Jepsen, D | 2 |
| Mathiesen, IHM | 2 |
| Sabra, W | 1 |
| Wang, W | 1 |
| Goepfert, C | 1 |
| Zeng, AP | 1 |
| Asensio-Grau, A | 1 |
| Calvo-Lerma, J | 1 |
| Ferriz-Jordán, M | 1 |
| García-Hernández, J | 1 |
| Heredia, A | 1 |
| Andrés, A | 1 |
| Katzenstein, T | 1 |
| Ritz, C | 1 |
| López-Neyra, A | 1 |
| Suárez, L | 1 |
| Muñoz, M | 1 |
| de Blas, A | 1 |
| Ruiz de Valbuena, M | 1 |
| Garriga, M | 1 |
| Calvo, J | 1 |
| Ribes, C | 1 |
| Girón Moreno, R | 1 |
| Máiz, L | 1 |
| González, D | 1 |
| Bousoño, C | 1 |
| Manzanares, J | 1 |
| Pastor, Ó | 1 |
| Martínez-Botas, J | 1 |
| Del Campo, R | 1 |
| Cantón, R | 1 |
| Roy, G | 1 |
| Menacho, M | 1 |
| Arroyo, D | 1 |
| Zamora, J | 1 |
| Soriano, JB | 1 |
| Lamas, A | 1 |
| Massip-Copiz, MM | 2 |
| Valdivieso, ÁG | 2 |
| Clauzure, M | 2 |
| Mori, C | 2 |
| Asensio, CJA | 2 |
| Aguilar, MÁ | 1 |
| Santa-Coloma, TA | 2 |
| Günday Türeli, N | 2 |
| Torge, A | 1 |
| Juntke, J | 1 |
| Schwarz, BC | 1 |
| Schneider-Daum, N | 1 |
| Türeli, AE | 2 |
| Lehr, CM | 1 |
| Schneider, M | 2 |
| Phan, J | 1 |
| Gallagher, T | 2 |
| Oliver, A | 1 |
| England, WE | 1 |
| Whiteson, K | 1 |
| Gao, B | 1 |
| Zhang, Y | 2 |
| Elbadawi-Sidhu, M | 1 |
| Lai, Z | 1 |
| Fiehn, O | 1 |
| Whiteson, KL | 1 |
| Wang, Y | 1 |
| Xiao, D | 1 |
| Liu, Q | 1 |
| Hu, C | 1 |
| Sun, J | 1 |
| Yang, C | 1 |
| Xu, P | 1 |
| Ma, C | 1 |
| Gao, C | 1 |
| Cancio, CE | 1 |
| Wu, X | 1 |
| Siehnel, RJ | 1 |
| Garudathri, J | 1 |
| Staudinger, BJ | 1 |
| Hisert, KB | 1 |
| Ozer, EA | 1 |
| Hauser, AR | 1 |
| Eng, JK | 1 |
| Manoil, C | 1 |
| Singh, PK | 1 |
| Bruce, JE | 1 |
| Osman, R | 1 |
| Al Jamal, KT | 1 |
| Kan, PL | 1 |
| Awad, G | 1 |
| Mortada, N | 1 |
| El-Shamy, AE | 1 |
| Alpar, O | 1 |
| Kolate, A | 1 |
| Kore, G | 1 |
| Lesimple, P | 1 |
| Baradia, D | 1 |
| Patil, S | 1 |
| Hanrahan, JW | 1 |
| Misra, A | 1 |
| McNeer, NA | 1 |
| Anandalingam, K | 1 |
| Fields, RJ | 1 |
| Caputo, C | 2 |
| Kopic, S | 1 |
| Gupta, A | 1 |
| Quijano, E | 1 |
| Polikoff, L | 1 |
| Kong, Y | 1 |
| Bahal, R | 1 |
| Geibel, JP | 1 |
| Glazer, PM | 1 |
| Saltzman, WM | 2 |
| Egan, ME | 2 |
| Greguš, M | 1 |
| Foret, F | 1 |
| Kindlová, D | 1 |
| Pokojová, E | 1 |
| Plutinský, M | 1 |
| Doubková, M | 1 |
| Merta, Z | 1 |
| Binková, I | 1 |
| Skřičková, J | 1 |
| Kubáň, P | 1 |
| Zang, X | 1 |
| Monge, ME | 1 |
| McCarty, NA | 1 |
| Stecenko, AA | 1 |
| Fernández, FM | 1 |
| Cartiera, MS | 1 |
| Ferreira, EC | 1 |
| Caplan, MJ | 1 |
| Bensel, T | 1 |
| Stotz, M | 1 |
| Borneff-Lipp, M | 1 |
| Wollschläger, B | 1 |
| Wienke, A | 1 |
| Taccetti, G | 1 |
| Campana, S | 1 |
| Meyer, KC | 1 |
| Lechner, U | 1 |
| Ulrich, M | 1 |
| Döring, G | 1 |
| Worlitzsch, D | 1 |
| Stevens, D | 1 |
| Oades, PJ | 1 |
| Armstrong, N | 1 |
| Williams, CA | 1 |
| Felten, ML | 1 |
| Sinaceur, M | 1 |
| Treilhaud, M | 1 |
| Roze, H | 1 |
| Mornex, JF | 1 |
| Pottecher, J | 1 |
| Journois, D | 1 |
| Fischler, M | 1 |
| Stern, M | 1 |
| Ulrich, K | 1 |
| Geddes, DM | 1 |
| Alton, EW | 1 |
| Moorcroft, AJ | 1 |
| Dodd, ME | 1 |
| Morris, J | 1 |
| Webb, AK | 1 |
| Ionescu, AA | 1 |
| Mickleborough, TD | 1 |
| Bolton, CE | 1 |
| Lindley, MR | 1 |
| Nixon, LS | 1 |
| Dunseath, G | 1 |
| Luzio, S | 1 |
| Owens, DR | 1 |
| Shale, DJ | 1 |
| Bardón, A | 1 |
| Ceder, O | 1 |
| Kollberg, H | 1 |
| Martin, D | 1 |
| Day, J | 1 |
| Ward, G | 1 |
| Carter, E | 1 |
| Chesrown, S | 1 |
| McLoughlin, P | 2 |
| McKeogh, D | 1 |
| Byrne, P | 1 |
| Finlay, G | 1 |
| Hayes, J | 1 |
| FitzGerald, MX | 2 |
| Thin, AG | 1 |
| Linnane, SJ | 1 |
| McKone, EF | 1 |
| Freaney, R | 1 |
| Gallagher, CG | 1 |
| Tantisira, KG | 1 |
| Systrom, DM | 1 |
| Ginns, LC | 1 |
| Bijman, J | 1 |
| Quinton, PM | 1 |
| Fellmann, N | 1 |
| Labbe, A | 1 |
| Gachon, AM | 1 |
| Coudert, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Eficacy of Long-term Suplementation With Docosahexaenoic Acid on Pulmonary, Sistemic and Intestinal Inflammation in Patients With Cystic Fibrosis[NCT01783613] | 96 participants (Actual) | Interventional | 2011-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for lactic acid and Cystic Fibrosis
| Article | Year |
|---|---|
Long-term docosahexaenoic acid (DHA) supplementation in cystic fibrosis patients: a randomized, multi-center, double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cystic Fibrosis; Cytokines; Docosahexaenoic | 2020 |
Exercise metabolism during moderate-intensity exercise in children with cystic fibrosis following heavy-intensity exercise.
Topics: Adolescent; Cardiovascular System; Child; Cystic Fibrosis; Exercise; Exercise Test; Exercise Toleran | 2011 |
Symptoms, lactate and exercise limitation at peak cycle ergometry in adults with cystic fibrosis.
Topics: Adult; Cystic Fibrosis; Dyspnea; Exercise Test; Exercise Tolerance; Female; Humans; Lactic Acid; Lun | 2005 |
Effects of breathing a normoxic helium mixture on exercise tolerance of patients with cystic fibrosis.
Topics: Adolescent; Adult; Cystic Fibrosis; Drug Combinations; Exercise Test; Exercise Tolerance; Female; He | 1994 |
28 other studies available for lactic acid and Cystic Fibrosis
| Article | Year |
|---|---|
Increased sputum lactate during oral glucose tolerance test in cystic fibrosis.
Topics: Blood Glucose; Cystic Fibrosis; Glucose; Glucose Tolerance Test; Humans; Inflammation; Lactic Acid; | 2022 |
Food web and metabolic interactions of the lung inhabitants Streptococcus pneumoniae and Pseudomonas aeruginosa.
Topics: Acetoin; Ammonia; Biofilms; Cystic Fibrosis; Food Chain; Glucose; Humans; Lactic Acid; Lung; Oxygen; | 2022 |
Effect of
Topics: Child; Cystic Fibrosis; Dysbiosis; Faecalibacterium; Fatty Acids; Humans; Lactic Acid; Lactobacillac | 2023 |
Neutrophil count in sputum is associated with increased sputum glucose and sputum L-lactate in cystic fibrosis.
Topics: Adult; Aged; Anti-Bacterial Agents; Biomarkers; Blood Glucose; Cystic Fibrosis; Female; Glucose; Gly | 2020 |
Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells.
Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; ErbB Recepto | 2021 |
Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections.
Topics: Animals; Cell Line; Ciprofloxacin; Cystic Fibrosis; Drug Carriers; Horses; Humans; Lactic Acid; Mucu | 2017 |
Fermentation products in the cystic fibrosis airways induce aggregation and dormancy-associated expression profiles in a CF clinical isolate of Pseudomonas aeruginosa.
Topics: Bacterial Proteins; Biofilms; Butylene Glycols; Cystic Fibrosis; Fermentation; Humans; Lactic Acid; | 2018 |
Tracking Polymicrobial Metabolism in Cystic Fibrosis Airways:
Topics: Acetates; Carbon Radioisotopes; Coinfection; Culture Media; Cystic Fibrosis; Glutamic Acid; Humans; | 2018 |
Two NAD-independent l-lactate dehydrogenases drive l-lactate utilization in Pseudomonas aeruginosa PAO1.
Topics: Bacterial Proteins; Culture Media; Cystic Fibrosis; Flavoproteins; Humans; L-Lactate Dehydrogenase; | 2018 |
Impairment of CFTR activity in cultured epithelial cells upregulates the expression and activity of LDH resulting in lactic acid hypersecretion.
Topics: Animals; Anthracenes; Caco-2 Cells; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regul | 2019 |
In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients.
Topics: Adult; Anti-Bacterial Agents; Bacterial Proteins; Carbon; Cystic Fibrosis; Female; Glyoxylates; Huma | 2019 |
Inhalable DNase I microparticles engineered with biologically active excipients.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Administration, Inhalation; Aerosols; Animals; Chitosan; Cystic | 2013 |
Polymer assisted entrapment of netilmicin in PLGA nanoparticles for sustained antibacterial activity.
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Humans; Lactic Acid; Nanoparticles; Netilmicin; P | 2015 |
Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium.
Topics: Animals; Cell Line; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; | 2015 |
Monitoring the ionic content of exhaled breath condensate in various respiratory diseases by capillary electrophoresis with contactless conductivity detection.
Topics: Acetates; Adult; Aged; Ammonium Compounds; Asthma; Breath Tests; Butyrates; Calcium; Chlorides; Crow | 2015 |
Optimization of ciprofloxacin complex loaded PLGA nanoparticles for pulmonary treatment of cystic fibrosis infections: Design of experiments approach.
Topics: Anti-Bacterial Agents; Biofilms; Chemistry, Pharmaceutical; Ciprofloxacin; Cystic Fibrosis; Drug Car | 2016 |
Feasibility of Early Detection of Cystic Fibrosis Acute Pulmonary Exacerbations by Exhaled Breath Condensate Metabolomics: A Pilot Study.
Topics: Adolescent; Adult; Biomarkers; Breath Tests; Chromatography, Liquid; Cyclohexanes; Cystic Fibrosis; | 2017 |
Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin.
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport, Active; Curcumin; Cyst | 2010 |
Lactate in cystic fibrosis sputum.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteria; Child; Chromatography, Gas; Comparative Ef | 2011 |
Factors associated with early graft dysfunction in cystic fibrosis patients receiving primary bilateral lung transplantation.
Topics: Adult; Anesthesia, General; Biomarkers; Cystic Fibrosis; Female; Humans; Lactic Acid; Lung; Lung Tra | 2012 |
Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo.
Topics: Animals; Animals, Newborn; beta-Galactosidase; Biocompatible Materials; COS Cells; Cystic Fibrosis; | 2003 |
The systemic inflammatory response to exercise in adults with cystic fibrosis.
Topics: Adult; Anaerobic Threshold; Cystic Fibrosis; Exercise; Female; Forced Expiratory Volume; Humans; Inf | 2006 |
Cystic fibrosis-like changes in saliva of healthy persons subjected to anaerobic exercise.
Topics: Adolescent; Adult; Aerobiosis; Anaerobiosis; Calcium; Child; Child, Preschool; Cystic Fibrosis; Hete | 1983 |
Assessment of fitness in patients with cystic fibrosis and mild lung disease.
Topics: Adult; Analysis of Variance; Cystic Fibrosis; Humans; Lactic Acid; Lung Diseases; Male; Physical Fit | 1997 |
Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis.
Topics: Adult; Cystic Fibrosis; Female; Humans; Lactic Acid; Male; Pulmonary Gas Exchange; Reproducibility o | 2002 |
An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation.
Topics: Adult; Anaerobic Threshold; Boston; Cystic Fibrosis; Female; Follow-Up Studies; Forced Expiratory Vo | 2002 |
Lactate and bicarbonate uptake in the sweat duct of cystic fibrosis and normal subjects.
Topics: Bicarbonates; Chlorides; Cystic Fibrosis; Humans; Hydrogen-Ion Concentration; Lactates; Lactic Acid; | 1987 |
Thermal sweat lactate in cystic fibrosis and in normal children.
Topics: Child; Child, Preschool; Chlorides; Cystic Fibrosis; Energy Metabolism; Hot Temperature; Humans; Inf | 1985 |