Page last updated: 2024-10-17

lactic acid and Cryptogenic Fibrosing Alveolitis

lactic acid has been researched along with Cryptogenic Fibrosing Alveolitis in 10 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Lactic acid and LDH5 were significantly elevated in IPF lung tissue compared with controls."5.38Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β. ( Dahanayake, T; Grant, G; Honnons, S; Hu, JZ; Isern, NG; Jones, C; Kottmann, RM; Kulkarni, AA; Lyda, E; Nathan, SD; Phipps, RP; Salibi, R; Sime, PJ; Smolnycki, KA, 2012)
"Radiation-induced lung injury (RILI) is a consequence of therapeutic thoracic irradiation (TR) for many cancers, and there are no FDA-approved curative strategies."1.91Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury. ( Allegood, JC; Camus, SV; Cowart, LA; Freeberg, MAT; Jackson, PD; Liu, J; Pierre-Louis Odoom, J; Sanchez Rosado, RM; Silvey, S; Sime, PJ; Szomju, BB; Thatcher, TH; Toft, R; Weiss, E, 2023)
"Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival."1.46Spermidine-mediated poly(lactic- ( Ding, J; Li, D; Li, G; Li, J; Tang, J; Wang, L; Zhang, H, 2017)
"Lactic acid and LDH5 were significantly elevated in IPF lung tissue compared with controls."1.38Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β. ( Dahanayake, T; Grant, G; Honnons, S; Hu, JZ; Isern, NG; Jones, C; Kottmann, RM; Kulkarni, AA; Lyda, E; Nathan, SD; Phipps, RP; Salibi, R; Sime, PJ; Smolnycki, KA, 2012)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (60.00)24.3611
2020's4 (40.00)2.80

Authors

AuthorsStudies
Newton, DA1
Lottes, RG1
Ryan, RM1
Spyropoulos, DD1
Baatz, JE1
Yang, L1
Gilbertsen, A1
Xia, H1
Benyumov, A1
Smith, K1
Herrera, J1
Racila, E1
Bitterman, PB1
Henke, CA1
Pierre-Louis Odoom, J1
Freeberg, MAT1
Camus, SV1
Toft, R1
Szomju, BB1
Sanchez Rosado, RM1
Jackson, PD1
Allegood, JC1
Silvey, S1
Liu, J1
Cowart, LA1
Weiss, E1
Thatcher, TH1
Sime, PJ2
Nho, RS1
Rice, C1
Prasad, J1
Bone, H1
Farkas, L1
Rojas, M1
Horowitz, JC1
Tang, J1
Li, J1
Li, G1
Zhang, H1
Wang, L1
Li, D1
Ding, J1
Kottmann, R1
Phipps, R1
Sime, P1
Worlitzsch, D1
Meyer, KC1
Döring, G1
O'Dwyer, DN1
Ashley, SL1
Moore, BB1
Kottmann, RM1
Kulkarni, AA1
Smolnycki, KA1
Lyda, E1
Dahanayake, T1
Salibi, R1
Honnons, S1
Jones, C1
Isern, NG1
Hu, JZ1
Nathan, SD1
Grant, G1
Phipps, RP1
Tuder, RM1
Lara, AR1
Thannickal, VJ1

Reviews

1 review available for lactic acid and Cryptogenic Fibrosing Alveolitis

ArticleYear
Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis.
    American journal of physiology. Lung cellular and molecular physiology, 2016, Sep-01, Volume: 311, Issue:3

    Topics: Animals; Autophagy; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Immunity, Innate; Intercellu

2016

Other Studies

9 other studies available for lactic acid and Cryptogenic Fibrosing Alveolitis

ArticleYear
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
    Respiratory research, 2021, Oct-28, Volume: 22, Issue:1

    Topics: A549 Cells; Alveolar Epithelial Cells; Case-Control Studies; Energy Metabolism; Humans; Idiopathic P

2021
Hypoxia enhances IPF mesenchymal progenitor cell fibrogenicity via the lactate/GPR81/HIF1α pathway.
    JCI insight, 2023, 02-22, Volume: 8, Issue:4

    Topics: Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Lactic Acid; Mesenchymal Stem Cells; Signal Transduc

2023
Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury.
    American journal of physiology. Lung cellular and molecular physiology, 2023, 06-01, Volume: 324, Issue:6

    Topics: Biomarkers; Breath Tests; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Lung; Lung Injury; Lun

2023
Persistent hypoxia promotes myofibroblast differentiation via GPR-81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis fibroblasts.
    Physiological reports, 2023, Volume: 11, Issue:17

    Topics: Fibroblasts; Humans; Hypoxia; Idiopathic Pulmonary Fibrosis; Isoenzymes; L-Lactate Dehydrogenase; La

2023
Spermidine-mediated poly(lactic-
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Coumarins; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Idiopathic Pulmon

2017
Reply: from idiopathic pulmonary fibrosis to cystic fibrosis: got lactate?
    American journal of respiratory and critical care medicine, 2013, Jul-01, Volume: 188, Issue:1

    Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transformi

2013
Lactate levels in airways of patients with cystic fibrosis and idiopathic pulmonary fibrosis.
    American journal of respiratory and critical care medicine, 2013, Jul-01, Volume: 188, Issue:1

    Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transformi

2013
Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β.
    American journal of respiratory and critical care medicine, 2012, Oct-15, Volume: 186, Issue:8

    Topics: Case-Control Studies; Cell Differentiation; Gene Expression Regulation, Enzymologic; Humans; Hydroge

2012
Lactate, a novel trigger of transforming growth factor-β activation in idiopathic pulmonary fibrosis.
    American journal of respiratory and critical care medicine, 2012, Oct-15, Volume: 186, Issue:8

    Topics: Cell Differentiation; Humans; Idiopathic Pulmonary Fibrosis; Lactic Acid; Myofibroblasts; Transformi

2012