lactic acid has been researched along with Conus Medullaris Syndrome in 5 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okon, EB | 1 |
| Streijger, F | 1 |
| Lee, JH | 1 |
| Anderson, LM | 1 |
| Russell, AK | 1 |
| Kwon, BK | 1 |
| Nagashima, H | 1 |
| Morio, Y | 1 |
| Meshitsuka, S | 1 |
| Yamane, K | 1 |
| Nanjo, Y | 1 |
| Teshima, R | 1 |
| Söderlund, CH | 1 |
| Pointillart, V | 1 |
| Pedram, M | 1 |
| Andrault, G | 1 |
| Vital, JM | 1 |
| Zhang, Y | 1 |
| Hillered, L | 2 |
| Olsson, Y | 2 |
| Holtz, A | 2 |
| Farooque, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)[NCT02182843] | 81 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Radiographic fusion was assessed at each operated level using the Bridwell fusion grading system:~Grade I (definite) - Fused with remodeling and trabeculae~Grade II (probable) - Graft intact, not fully remodeled and incorporated through, no lucencies~Grade III (probably not) - Graft intact, but definite lucency at the top or bottom of the graft~Grade IV (no) - Definitely not fused, with resorption of bone graft or collapse.~Radiographic success was defined as grade 1 or 2 fusion at every operated level at 24 months" (NCT02182843)
Timeframe: 24 Months
| Intervention | Participants (Count of Participants) |
|---|---|
| Cellentra VCBM | 35 |
Neck Disability Index (NDI) is a patient-completed, condition-specific functional status questionnaire including pain, personal care, lifting, reading, headaches, concentration, work, driving, sleeping and recreation. Each of the 10 items is scored from 0 - 5, with a maximum score of 50. The obtained score is multiplied by 2 to produce a percentage score. A higher score indicates more patient-rated disability (0 points or 0% means : no activity limitations , 50 points or 100% means complete activity limitation). The minimal clinically important difference or change (MCID / MCIC) is described as the smallest difference or change that patients perceive as beneficial. In patients with cervical radiculopathy the MCID is 7 points of change ( 14%). In order to demonstrate improvement in status, the NDI would need to be reduced by at least 14%. (NCT02182843)
Timeframe: 12 months after device implantation
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Baseline | 12 months | Mean Change in NDI | |
| Cellentra VCBM | 52.1 | 28.5 | 24.0 |
1 trial available for lactic acid and Conus Medullaris Syndrome
| Article | Year |
|---|---|
Radiolucent cage for cervical vertebral reconstruction: a prospective study of 17 cases with 2-year minimum follow-up.
Topics: Adult; Aged; Aged, 80 and over; Biocompatible Materials; Biomechanical Phenomena; Bone Transplantati | 2004 |
4 other studies available for lactic acid and Conus Medullaris Syndrome
| Article | Year |
|---|---|
Intraparenchymal microdialysis after acute spinal cord injury reveals differential metabolic responses to contusive versus compressive mechanisms of injury.
Topics: Animals; Blood Pressure; Energy Metabolism; Female; Glucose; Heart Rate; Ischemia; Lactic Acid; Micr | 2013 |
High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy.
Topics: Acetic Acid; Adult; Aged; Aged, 80 and over; Alanine; Cervical Vertebrae; Citric Acid; Female; Gluta | 2010 |
Time course of energy perturbation after compression trauma to the spinal cord: an experimental study in the rat using microdialysis.
Topics: Analysis of Variance; Animals; Dialysis; Energy Metabolism; Hypoxanthine; Hypoxanthines; Inosine; La | 1993 |
Effects of moderate hypothermia on extracellular lactic acid and amino acids after severe compression injury of rat spinal cord.
Topics: Acidosis, Lactic; Amino Acids; Animals; Excitatory Amino Acids; Extracellular Space; Hypothermia, In | 1997 |