lactic acid has been researched along with Complex IV Deficiency in 22 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis." | 7.67 | Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985) |
| "Three bedouin children with mitochondrial myopathy due to cytochrome c oxidase deficiency presented with progressive muscle weakness, failure to thrive, proximal renal tubular acidosis, and lactic acidemia leading to death." | 3.68 | Autosomal recessive lethal infantile cytochrome C oxidase deficiency. ( Aladjem, M; Barash, V; Barr, J; DiMauro, S; Eshel, G; Fried, K; Gutman, A; Lahat, E, 1991) |
| " Patients with mitochondrial encephalopathy with lactic acidosis and stroke-like episodes demonstrated only minor changes in redox state and in the behavior of the mitochondrial respiratory chain." | 3.68 | The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia. ( Capaldi, R; Chow, W; Glerum, DM; Lightowlers, R; Petrova-Benedict, R; Robinson, BH, 1990) |
| "An enzymatic study of cultured skin fibroblasts was made in 28 patients with lactic acidosis." | 3.67 | Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy. ( Iinuma, K; Ito, T; Miyabayashi, S; Narisawa, K; Tada, K, 1985) |
| "Alexander disease is a neurodegenerative disorder characterized by macrocephaly and progressive demyelination with frontal lobe preponderance." | 1.33 | Early mitochondrial dysfunction in an infant with Alexander disease. ( Cáceres-Marzal, C; Fernández, S; Galán, E; Vaquerizo, J, 2006) |
| "Focal COX deficiency was found in 14 (93%) of 15 patients and in nine (60%) of 15 controls." | 1.31 | Impaired redox status and cytochrome c oxidase deficiency in patients with polymyalgia rheumatica. ( Authier, FJ; Chariot, P; Chevalier, X; Drogou, I; Gherardi, R; Yerroum, M, 2001) |
| "Here, we report on cytochrome c oxidase deficiency in the liver but not in the skeletal muscle of a 5-month-old girl who presented hepatic failure in early infancy." | 1.29 | Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure. ( Cerrone, R; Chretien, D; Edery, P; Fabre, M; Gérard, B; Munnich, A; Rabier, D; Rambaud, C; Rötig, A; Saudubray, JM, 1994) |
| "Amniocytes with an established cytochrome c oxidase deficiency were also investigated." | 1.28 | Prenatal diagnosis of systemic disorders of the respiratory chain in cultured amniocytes and chorionic villus fibroblasts by studying the formation of lactate and pyruvate from glucose. ( Bakkeren, JA; Feller, N; Ruitenbeek, W; Ruiter, J; Sengers, RC; Trijbels, JM; Wanders, RJ; Wijburg, FA, 1992) |
| "The presentation and clinical course of cytochrome c oxidase deficiency are highly variable and the diagnosis of cytochrome c oxidase deficiency should be considered in all patients with lactic acidosis or subacute necrotizing encephalomyelopathy." | 1.28 | Variable presentation of cytochrome c oxidase deficiency. ( Cunniff, C; Keppler, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 12 (54.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yu, XL | 1 |
| Yan, CZ | 1 |
| Ji, KQ | 1 |
| Lin, PF | 1 |
| Xu, XB | 1 |
| Dai, TJ | 1 |
| Li, W | 1 |
| Zhao, YY | 1 |
| Szklarczyk, R | 1 |
| Wanschers, BF | 1 |
| Nijtmans, LG | 2 |
| Rodenburg, RJ | 1 |
| Zschocke, J | 1 |
| Dikow, N | 1 |
| van den Brand, MA | 1 |
| Hendriks-Franssen, MG | 1 |
| Gilissen, C | 1 |
| Veltman, JA | 1 |
| Nooteboom, M | 1 |
| Koopman, WJ | 1 |
| Willems, PH | 1 |
| Smeitink, JA | 2 |
| Huynen, MA | 1 |
| van den Heuvel, LP | 1 |
| Cáceres-Marzal, C | 1 |
| Vaquerizo, J | 1 |
| Galán, E | 1 |
| Fernández, S | 1 |
| Narisawa, K | 2 |
| Miyabayashi, S | 2 |
| Tada, K | 2 |
| Edery, P | 1 |
| Gérard, B | 1 |
| Chretien, D | 1 |
| Rötig, A | 1 |
| Cerrone, R | 1 |
| Rabier, D | 1 |
| Rambaud, C | 1 |
| Fabre, M | 1 |
| Saudubray, JM | 2 |
| Munnich, A | 1 |
| Robinson, BH | 2 |
| Bakker, HD | 1 |
| Van den Bogert, C | 2 |
| Drewes, JG | 1 |
| Barth, PG | 2 |
| Scholte, HR | 3 |
| Wanders, RJ | 4 |
| Ruitenbeek, W | 4 |
| Lincke, CR | 1 |
| Tamminga, P | 1 |
| Rubio-Gozalbo, ME | 1 |
| Ter Laak, H | 1 |
| Mullaart, RA | 1 |
| Schuelke, M | 1 |
| Mariman, EC | 1 |
| Sengers, RC | 3 |
| Gabreëls, FJ | 1 |
| Rizzo, C | 1 |
| Bertini, E | 1 |
| Piemonte, F | 1 |
| Leuzzi, V | 1 |
| Sabetta, G | 1 |
| Federici, G | 1 |
| Luchetti, A | 1 |
| Dionisi-Vici, C | 1 |
| Murakami, N | 1 |
| Sakuta, R | 1 |
| Chariot, P | 1 |
| Chevalier, X | 1 |
| Yerroum, M | 1 |
| Drogou, I | 1 |
| Authier, FJ | 1 |
| Gherardi, R | 1 |
| Wijburg, FA | 2 |
| Ruiter, J | 1 |
| Trijbels, JM | 2 |
| Bakkeren, JA | 1 |
| Feller, N | 2 |
| Keppler, K | 1 |
| Cunniff, C | 1 |
| Beyenburg, S | 1 |
| von Wersebe, O | 1 |
| Zierz, S | 1 |
| Lutz, R | 1 |
| Garnica, A | 1 |
| Shires, A | 1 |
| Freneaux, E | 1 |
| De Vivo, D | 1 |
| Neuhoff, P | 1 |
| Rhead, WJ | 1 |
| Eshel, G | 1 |
| Lahat, E | 1 |
| Fried, K | 1 |
| Barr, J | 1 |
| Barash, V | 1 |
| Gutman, A | 1 |
| DiMauro, S | 1 |
| Aladjem, M | 1 |
| Przyrembel, H | 1 |
| Glerum, DM | 1 |
| Chow, W | 1 |
| Petrova-Benedict, R | 1 |
| Lightowlers, R | 1 |
| Capaldi, R | 1 |
| Ogier, H | 1 |
| Lombes, A | 1 |
| Poll-The, BT | 1 |
| Fardeau, M | 1 |
| Alcardi, J | 1 |
| Vignes, B | 1 |
| Niaudet, P | 1 |
| Ito, T | 1 |
| Iinuma, K | 1 |
| Yokochi, K | 1 |
2 reviews available for lactic acid and Complex IV Deficiency
| Article | Year |
|---|---|
Lacticacidemia.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Animals; Binding Sites; Carrier Proteins; Cytochrome | 1993 |
[Pure mitochondrial myopathy].
Topics: Child; Cytochrome-c Oxidase Deficiency; Electron Transport Complex I; Electron Transport Complex II; | 2001 |
20 other studies available for lactic acid and Complex IV Deficiency
| Article | Year |
|---|---|
Clinical, Neuroimaging, and Pathological Analyses of 13 Chinese Leigh Syndrome Patients with Mitochondrial DNA Mutations.
Topics: Child; Child, Preschool; Creatine Kinase; Cytochrome-c Oxidase Deficiency; DNA, Mitochondrial; Fasti | 2018 |
A mutation in the FAM36A gene, the human ortholog of COX20, impairs cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia.
Topics: Abnormalities, Multiple; Amino Acid Sequence; Animals; Ataxia; Base Sequence; Cells, Cultured; Child | 2013 |
Early mitochondrial dysfunction in an infant with Alexander disease.
Topics: Alexander Disease; Biopsy; Brain; Cytochrome-c Oxidase Deficiency; Diagnosis, Differential; Female; | 2006 |
[Congenital lactic acidemia].
Topics: Acidosis; Brain Diseases, Metabolic; Child; Cytochrome-c Oxidase Deficiency; Humans; Infant; Lactate | 1983 |
Liver cytochrome c oxidase deficiency in a case of neonatal-onset hepatic failure.
Topics: Cytochrome-c Oxidase Deficiency; Female; Humans; Infant; Lactates; Lactic Acid; Liver; Liver Failure | 1994 |
Progressive generalized brain atrophy and infantile spasms associated with cytochrome c oxidase deficiency.
Topics: Acidosis; Atrophy; Brain; Cytochrome-c Oxidase Deficiency; Humans; Infant, Newborn; Lactates; Lactic | 1996 |
Cerebellar hypoplasia in respiratory chain dysfunction.
Topics: Cerebellum; Consanguinity; Cytochrome-c Oxidase Deficiency; Fatal Outcome; Female; Humans; Infant, N | 1996 |
Spinal muscular atrophy-like picture, cardiomyopathy, and cytochrome c oxidase deficiency.
Topics: Blotting, Western; Cardiomegaly; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Huma | 1999 |
Oxidative abnormalities in Menkes disease.
Topics: Cells, Cultured; Ceruloplasmin; Copper; Cytochrome-c Oxidase Deficiency; Fibroblasts; Histidine; Hum | 2000 |
Impaired redox status and cytochrome c oxidase deficiency in patients with polymyalgia rheumatica.
Topics: Aged; Aged, 80 and over; Biopsy; Case-Control Studies; Cytochrome-c Oxidase Deficiency; Female; Huma | 2001 |
Prenatal diagnosis of systemic disorders of the respiratory chain in cultured amniocytes and chorionic villus fibroblasts by studying the formation of lactate and pyruvate from glucose.
Topics: Amnion; Cells, Cultured; Chorionic Villi; Cytochrome-c Oxidase Deficiency; Female; Fibroblasts; Gluc | 1992 |
Variable presentation of cytochrome c oxidase deficiency.
Topics: Cytochrome-c Oxidase Deficiency; Female; Humans; Infant, Newborn; Lactates; Lactic Acid; Male; Metab | 1992 |
[Delayed manifestation of mitochondrial myopathy--complex I and IV deficiency of the mitochondrial respiratory chain with progressive paresis].
Topics: Biopsy; Cytochrome-c Oxidase Deficiency; Electromyography; Humans; Lactates; Lactic Acid; Male; Midd | 1991 |
An atypical case of cytochrome c oxidase deficiency with biochemical heterogeneity in fibroblasts.
Topics: Cells, Cultured; Child, Preschool; Cytochrome-c Oxidase Deficiency; Electrophoresis, Polyacrylamide | 1991 |
Autosomal recessive lethal infantile cytochrome C oxidase deficiency.
Topics: Acidosis, Renal Tubular; Child, Preschool; Consanguinity; Cytochrome-c Oxidase Deficiency; Electron | 1991 |
Detection of respiratory chain dysfunction by measuring lactate and pyruvate production in cultured fibroblasts.
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Child, Preschool; Cytochrome-c Oxidase Defici | 1990 |
The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia.
Topics: Acidosis, Lactic; Brain Diseases; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Hum | 1990 |
de Toni-Fanconi-Debré syndrome with Leigh syndrome revealing severe muscle cytochrome c oxidase deficiency.
Topics: Brain Diseases, Metabolic; Child, Preschool; Cytochrome-c Oxidase Deficiency; Fanconi Syndrome; Fema | 1988 |
Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy.
Topics: Acidosis; Adolescent; Brain Diseases, Metabolic; Carboxy-Lyases; Cells, Cultured; Child; Child, Pres | 1985 |
[Neurological approach to mitochondrial abnormalities].
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Cytochrome-c Oxidase Deficiency; Female; Humans | 1987 |