lactic acid has been researched along with Compensatory Hyperinsulinemia in 45 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Food intake and body weight, circulating lactic acid, glucose, and insulin as well as fetal body weight and number were unaffected by the exercise protocol." | 3.70 | Aerobic exercise during pregnancy reverts maternal insulin resistance in rats. ( Herrera, E; Iglesias, MA; López-Luna, P; Muñoz, C, 1998) |
| "During hyperinsulinemia, interstitial concentrations of glucose in skeletal muscle decreased in response to ghrelin exposure [2." | 2.78 | Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects. ( Jørgensen, JO; Møller, N; Vestergaard, ET, 2013) |
| "Both cancer and diabetes have been associated with abnormal lactate metabolism and high level of lactate production is the key biological property of these diseases." | 2.53 | Lactate, a Neglected Factor for Diabetes and Cancer Interaction. ( Atefi, M; Dong, Y; Elshimali, Y; Liu, Y; Vadgama, JV; Wu, Y, 2016) |
| "Glucose tolerance and hyperinsulinemia improved (P < 0." | 1.43 | Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. ( Erkin-Cakmak, A; Gugliucci, A; Lustig, RH; Mulligan, K; Noworolski, SM; Schwarz, JM; Tai, VW; Wen, MJ, 2016) |
| "For this purpose, a condition of hyperinsulinemia/hypoglycaemia was obtained with an intraperitoneal (ip) injection of regular insulin (1." | 1.35 | Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia. ( Bazotte, RB; Curi, R; Felisberto-Junior, AM; Garcia, RF; Oliveira-Yamashita, F, 2009) |
| "the FGU response to hyperinsulinemia." | 1.35 | Effects of Intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals. ( Gudbjörnsdóttir, S; Jansson, PA; Lind, L; Lönnroth, P; Murdolo, G; Sjöstrand, M; Strindberg, L, 2008) |
| "We studied the effect of acute hyperinsulinemia on amino acid (AA) utilization and oxidation rates independent of insulin-enhanced glucose metabolism in fetal sheep." | 1.33 | Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus. ( Brown, LD; Hay, WW, 2006) |
| "Normoglycemic hyperinsulinemia caused no change in either retinal [3H]-radioactivity levels or [3H]-[R/VH] while decreasing retinal [14C]-radioactivity levels and retina to vitreous ratios of 14C-radioactivity levels." | 1.32 | Effects of insulin-induced acute hypoglycemia and normoglycemic hyperinsulinemia on the retinal uptake and ocular metabolism of glucose in rabbits. ( Amico, MC; Mattioli, F; Memoli, A; Muller, A; Romanelli, L; Savini, G, 2004) |
| "Because of the hyperinsulinemia and reduced NHGU, more glucose is utilized by peripheral tissues." | 1.31 | Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN. ( Chen, SS; Donmoyer, CM; Ejiofor, J; Hande, SA; Lacy, DB; McGuinness, OP, 2000) |
| "Ten patients with type 2 diabetes and ten healthy controls matched for sex, age, and body mass index were investigated." | 1.31 | Estimations of muscle interstitial insulin, glucose, and lactate in type 2 diabetic subjects. ( Holmäng, A; Lönnroth, P; Sjöstrand, M; Strindberg, L, 2000) |
| " This was associated with a 3 fold increase in insulin concentrations, even in the presence of adrenaline at a dosage which inhibits glucose-induced insulin release." | 1.30 | Glucose-lowering effect of BTS 67 582. ( Bailey, CJ; Page, T, 1997) |
| "The T-treated rats showed insulin resistance with both techniques, which was overcome with time and increasing insulin concentrations during the clamp measurements." | 1.30 | Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats. ( Björntorp, P; Eriksson, E; Holmäng, A; Niklasson, M; Nilsson, C, 1998) |
| "Extreme hyperinsulinemia strongly reversed postabsorptive muscle's phenylalanine balance from a net release to an uptake (P < 0." | 1.30 | Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm. ( Barrett, EJ; Fryburg, DA; Hillier, TA; Jahn, LA, 1998) |
| "In summary, during physiological hyperinsulinemia 1) a blood flow increase was detected in the calf and forearm, but not in the studied muscles of these limbs; 2) the blood flow increased in the subcutaneous adipose tissue; and 3) the estimated arterial-interstitial glucose difference increased in both muscles studied and was larger in the forearm muscle than the arteriovenous glucose difference over the forearm." | 1.30 | Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis. ( Henriksson, J; Lind, L; Lithell, H; Millgård, J; Rosdahl, H; Ungerstedt, U, 1998) |
| "Glycerol release was lowered by metformin during the 3-h experiment (P<0." | 1.30 | Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study. ( Adler, G; Alt, A; Ditschuneit, HH; Flechtner-Mors, M; Jenkinson, CP, 1999) |
| "The principal response to hyperinsulinemia was a decrease in the recycling of OAA to lactate, because there was no significant change in the conversion of OAA to PEP." | 1.29 | Response of phosphoenolpyruvate cycle activity to fasting and to hyperinsulinemia in human subjects. ( Baba, H; Chinkes, D; Rosenblatt, J; Wolfe, RR; Zhang, XJ, 1996) |
| "It is concluded that hyperinsulinemia and, to a lesser extent, hyperglycemia stimulate glucose conversion into lactate in adipocytes." | 1.29 | Effects of hyperinsulinemia and hyperglycemia on lactate release and local blood flow in subcutaneous adipose tissue of healthy humans. ( Henry, S; Jéquier, E; Schneiter, P; Tappy, L, 1996) |
| "A 64-year-old female with McArdle's disease and non-insulin-dependent diabetes mellitus (NIDDM) is reported." | 1.29 | McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance. ( Amano, K; Ichikawa, Y; Kono, N; Maruyama, H; Nakamoto, S; Saruta, T; Takei, I; Yamauchi, A, 1996) |
| "Transient hyperinsulinemia has been incriminated as a contributing factor to endotoxin-induced hypoglycemia." | 1.27 | Persistent hyperinsulinemia due to induced euglycemia in awake endotoxic minipigs. ( Chandrasena, LG; Cleek, JL; Fettman, MJ; Hand, MS; Mason, RA; Phillips, RW, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.67) | 18.7374 |
| 1990's | 16 (35.56) | 18.2507 |
| 2000's | 19 (42.22) | 29.6817 |
| 2010's | 7 (15.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vestergaard, ET | 1 |
| Møller, N | 1 |
| Jørgensen, JO | 1 |
| Corvino, SB | 1 |
| Netto, AO | 1 |
| Sinzato, YK | 1 |
| Campos, KE | 1 |
| Calderon, IM | 1 |
| Rudge, MV | 1 |
| Volpato, GT | 1 |
| Zambrano, E | 1 |
| Damasceno, DC | 1 |
| Lustig, RH | 1 |
| Mulligan, K | 1 |
| Noworolski, SM | 1 |
| Tai, VW | 1 |
| Wen, MJ | 1 |
| Erkin-Cakmak, A | 1 |
| Gugliucci, A | 1 |
| Schwarz, JM | 1 |
| Wu, Y | 1 |
| Dong, Y | 1 |
| Atefi, M | 1 |
| Liu, Y | 1 |
| Elshimali, Y | 1 |
| Vadgama, JV | 1 |
| Oliveira-Yamashita, F | 1 |
| Garcia, RF | 1 |
| Felisberto-Junior, AM | 1 |
| Curi, R | 1 |
| Bazotte, RB | 1 |
| Mackenzie, R | 1 |
| Maxwell, N | 1 |
| Castle, P | 1 |
| Elliott, B | 1 |
| Brickley, G | 1 |
| Watt, P | 1 |
| Pullen, TJ | 1 |
| Sylow, L | 1 |
| Sun, G | 1 |
| Halestrap, AP | 1 |
| Richter, EA | 1 |
| Rutter, GA | 1 |
| Yates, DT | 1 |
| Macko, AR | 1 |
| Chen, X | 1 |
| Green, AS | 1 |
| Kelly, AC | 1 |
| Anderson, MJ | 1 |
| Fowden, AL | 1 |
| Limesand, SW | 1 |
| Romanelli, L | 1 |
| Amico, MC | 1 |
| Mattioli, F | 1 |
| Memoli, A | 1 |
| Savini, G | 1 |
| Muller, A | 1 |
| Brown, LD | 1 |
| Hay, WW | 2 |
| van Wezel, HB | 1 |
| Zuurbier, CJ | 1 |
| de Jonge, E | 1 |
| van Dam, EW | 1 |
| van Dijk, J | 1 |
| Endert, E | 1 |
| de Mol, BA | 1 |
| Fliers, E | 1 |
| Gonsolin, D | 1 |
| Couturier, K | 1 |
| Garait, B | 1 |
| Rondel, S | 1 |
| Novel-Chaté, V | 1 |
| Peltier, S | 1 |
| Faure, P | 1 |
| Gachon, P | 1 |
| Boirie, Y | 1 |
| Keriel, C | 1 |
| Favier, R | 1 |
| Pepe, S | 1 |
| Demaison, L | 1 |
| Leverve, X | 1 |
| Wallace, JM | 1 |
| Milne, JS | 1 |
| Aitken, RP | 1 |
| Eggleston, EM | 1 |
| Jahn, LA | 2 |
| Barrett, EJ | 2 |
| Moore, MC | 2 |
| Dicostanzo, CA | 1 |
| Smith, MS | 1 |
| Farmer, B | 1 |
| Rodewald, TD | 1 |
| Neal, DW | 2 |
| Williams, PE | 1 |
| Cherrington, AD | 2 |
| Murdolo, G | 1 |
| Sjöstrand, M | 2 |
| Strindberg, L | 2 |
| Gudbjörnsdóttir, S | 1 |
| Lind, L | 2 |
| Lönnroth, P | 2 |
| Jansson, PA | 2 |
| Hand, MS | 1 |
| Fettman, MJ | 1 |
| Chandrasena, LG | 1 |
| Cleek, JL | 1 |
| Mason, RA | 1 |
| Phillips, RW | 1 |
| Adeleye, GA | 1 |
| Al-Jibouri, LM | 1 |
| Furman, BL | 1 |
| Parratt, JR | 1 |
| Paquot, N | 1 |
| Schneiter, P | 2 |
| Cayeux, MC | 1 |
| Chiolero, R | 1 |
| Temler, E | 1 |
| Jequier, E | 2 |
| Tappy, L | 2 |
| Wolfe, RR | 1 |
| Chinkes, D | 1 |
| Baba, H | 1 |
| Rosenblatt, J | 1 |
| Zhang, XJ | 1 |
| Henry, S | 1 |
| Yamauchi, A | 1 |
| Amano, K | 1 |
| Ichikawa, Y | 1 |
| Nakamoto, S | 1 |
| Takei, I | 1 |
| Maruyama, H | 1 |
| Kono, N | 1 |
| Saruta, T | 1 |
| Marmy-Conus, N | 1 |
| Fabris, S | 1 |
| Proietto, J | 1 |
| Hargreaves, M | 1 |
| Page, T | 1 |
| Bailey, CJ | 1 |
| Nilsson, C | 1 |
| Niklasson, M | 1 |
| Eriksson, E | 1 |
| Björntorp, P | 1 |
| Holmäng, A | 2 |
| Magnan, C | 1 |
| Laury, MC | 1 |
| Adnot, P | 1 |
| Doaré, L | 1 |
| Boucontet, L | 1 |
| Kergoat, M | 1 |
| Pénicaud, L | 1 |
| Ktorza, A | 1 |
| Gilbert, M | 1 |
| Sato, T | 1 |
| Magata, K | 1 |
| Koga, N | 1 |
| Mitsumoto, Y | 1 |
| Hillier, TA | 1 |
| Fryburg, DA | 1 |
| Rosdahl, H | 1 |
| Millgård, J | 1 |
| Lithell, H | 1 |
| Ungerstedt, U | 1 |
| Henriksson, J | 1 |
| López-Luna, P | 1 |
| Iglesias, MA | 1 |
| Muñoz, C | 1 |
| Herrera, E | 1 |
| Ellmerer, M | 1 |
| Schaupp, L | 1 |
| Sendlhofer, G | 1 |
| Wutte, A | 1 |
| Brunner, GA | 1 |
| Trajanoski, Z | 1 |
| Skrabal, F | 1 |
| Wach, P | 1 |
| Pieber, TR | 1 |
| Lewis, GF | 1 |
| Carpentier, A | 1 |
| Bilinski, D | 1 |
| Giacca, A | 1 |
| Vranic, M | 1 |
| de L Costello, AM | 1 |
| Pal, DK | 1 |
| Manandhar, DS | 1 |
| Rajbhandari, S | 1 |
| Land, JM | 1 |
| Patel, N | 1 |
| Flechtner-Mors, M | 1 |
| Ditschuneit, HH | 1 |
| Jenkinson, CP | 1 |
| Alt, A | 1 |
| Adler, G | 1 |
| Kusano, S | 1 |
| Abe, H | 1 |
| Donmoyer, CM | 1 |
| Chen, SS | 1 |
| Hande, SA | 1 |
| Lacy, DB | 1 |
| Ejiofor, J | 1 |
| McGuinness, OP | 1 |
| Ebeling, P | 1 |
| Tuominen, JA | 1 |
| Laipio, ML | 1 |
| Virtanen, MA | 1 |
| Koivisto, E | 1 |
| Koivisto, VA | 1 |
| Sandqvist, MM | 1 |
| Eriksson, JW | 1 |
| Greer, F | 1 |
| Hudson, R | 1 |
| Ross, R | 1 |
| Graham, T | 1 |
| Shiota, M | 1 |
| Galassetti, P | 1 |
| Monohan, M | 1 |
| Shulman, GI | 1 |
| Hoffman, RP | 1 |
| Sinkey, CA | 1 |
| Dopp, JM | 1 |
| Phillips, BG | 1 |
| Keller, U | 1 |
| Turkalj, I | 1 |
| Laager, R | 1 |
| Bloesch, D | 1 |
| Bilz, S | 1 |
| Lundgren, F | 1 |
| Edén, E | 1 |
| Arfvidsson, B | 1 |
| Lundholm, K | 1 |
| Dhananjaya Naidu, M | 1 |
| Ravindran, K | 1 |
| Swami, KS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Local Metabolic Effects of Ghrelin: A Clinical Microdialysis Study[NCT01595373] | Early Phase 1 | 10 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
| Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome[NCT04575844] | Phase 4 | 80 participants (Anticipated) | Interventional | 2020-11-01 | Recruiting | ||
| Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome[NCT02633488] | 19 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)[NCT03883412] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-02-28 | Recruiting | ||
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans[NCT02490124] | 7 participants (Actual) | Observational | 2014-12-31 | Completed | |||
| The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes[NCT03174288] | 32 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Influence of Treatment With Olanzapine or Ziprasidone on Transcapillary Glucose Transport in Human Skeletal Muscle[NCT00297960] | Phase 4 | 0 participants | Interventional | 2005-04-30 | Completed | ||
| New Electrophoretic Approaches in Studies of Obesity and Diabetes[NCT03189732] | 10 participants (Actual) | Interventional | 2015-10-01 | Completed | |||
| Does Combined Caffeine and Carbohydrate Ingestion Counter the Exercise-mediated Fall in Glycaemia in Individuals With Type 1 Diabetes on Insulin Degludec? The DE-CAF Study[NCT04671043] | 21 participants (Actual) | Interventional | 2022-02-04 | Completed | |||
| An Acute Randomized Dose-finding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Carbohydrate Metabolism: The Fructose and Allulose Catalytic Effects (FACE) Study[NCT02459834] | 50 participants (Actual) | Interventional | 2015-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
brachial artery ultrasonography % flow-mediated dilatation (FMD) for assessing endothelial function before and after an insulin clamp to assess insulin's effect on the vasculature (NCT02633488)
Timeframe: before and after 12 weeks on placebo or metformin
| Intervention | percentage of artery dilation (Mean) |
|---|---|
| Pre and Post Placebo 12 Weeks | 6.1 |
| Pre and Post Metformin 12 Weeks | 6.2 |
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
1 review available for lactic acid and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
Topics: Animals; Cell Line, Tumor; Diabetes Complications; Diabetes Mellitus; Disease Progression; Humans; H | 2016 |
7 trials available for lactic acid and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects.
Topics: Adipose Tissue; Administration, Oral; Blood Glucose; Extracellular Fluid; Fatty Acids, Nonesterified | 2013 |
Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes.
Topics: Algorithms; Blood Glucose; Cross-Over Studies; Deuterium; Diabetes Mellitus, Type 2; Exercise; Gluco | 2012 |
Differential effects of a perioperative hyperinsulinemic normoglycemic clamp on the neurohumoral stress response during coronary artery surgery.
Topics: Adrenocorticotropic Hormone; Aged; Blood Glucose; Coronary Artery Bypass; Female; Humans; Hydrocorti | 2006 |
Preexercise glucose ingestion and glucose kinetics during exercise.
Topics: Adult; Blood Glucose; Exercise; Fatty Acids, Nonesterified; Glucose; Hormones; Humans; Hyperinsulini | 1996 |
Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans.
Topics: Administration, Oral; Adult; C-Peptide; Caffeine; Calorimetry; Double-Blind Method; Fatty Acids, Non | 2001 |
Systemic and local adrenergic regulation of muscle glucose utilization during hypoglycemia in healthy subjects.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Arteries; Blood Flow Velocity; Blo | 2002 |
Effects of medium- and long-chain fatty acids on whole body leucine and glucose kinetics in man.
Topics: Adult; C-Peptide; Carbon Isotopes; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Glucose; Gluco | 2002 |
37 other studies available for lactic acid and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Intrauterine Growth Restricted Rats Exercised at Pregnancy: Maternal-Fetal Repercussions.
Topics: Acidosis, Lactic; Animals; Biomarkers; Birth Weight; Blood Glucose; Diabetes Mellitus, Experimental; | 2015 |
Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome.
Topics: Absorptiometry, Photon; Adiposity; Adolescent; Black or African American; Blood Pressure; Body Weigh | 2016 |
Evidence that L-glutamine is better than L-alanine as gluconeogenic substrate in perfused liver of weaned fasted rats submitted to short-term insulin-induced hypoglycaemia.
Topics: Alanine; Animals; Fasting; Gluconeogenesis; Glucose; Glutamine; Glycerol; Hyperinsulinism; Hypoglyce | 2009 |
Overexpression of monocarboxylate transporter-1 (SLC16A1) in mouse pancreatic β-cells leads to relative hyperinsulinism during exercise.
Topics: Animals; Blood Glucose; Doxycycline; Female; Hyperinsulinism; Insulin; Insulin Secretion; Insulin-Se | 2012 |
Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep.
Topics: Adrenal Glands; Animals; Blood Glucose; Chromaffin Cells; Epinephrine; Female; Fetus; Hyperinsulinis | 2012 |
Effects of insulin-induced acute hypoglycemia and normoglycemic hyperinsulinemia on the retinal uptake and ocular metabolism of glucose in rabbits.
Topics: Animals; Biotransformation; Blood Glucose; Choroid; Deoxyglucose; Eye; Glucose; Glucose Clamp Techni | 2004 |
Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus.
Topics: Algorithms; Amino Acids; Amino Acids, Branched-Chain; Animals; Blood Gas Analysis; Blood Glucose; Fe | 2006 |
High dietary sucrose triggers hyperinsulinemia, increases myocardial beta-oxidation, reduces glycolytic flux and delays post-ischemic contractile recovery.
Topics: Animals; Blood Glucose; Body Weight; Dietary Sucrose; Glycolysis; Hyperinsulinism; In Vitro Techniqu | 2007 |
Sensitivity to metabolic signals in late-gestation growth-restricted fetuses from rapidly growing adolescent sheep.
Topics: Adiposity; Animals; Body Weight; Female; Fetal Growth Retardation; Fetus; Glucose; Glucose Clamp Tec | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.
Topics: Adult; Biological Transport; Blood Glucose; Brachial Artery; Forearm; Humans; Hyperinsulinism; Infus | 2007 |
Hepatic portal venous delivery of a nitric oxide synthase inhibitor enhances net hepatic glucose uptake.
Topics: Animals; Blood Glucose; Carbon; Catheterization; Dogs; Dose-Response Relationship, Drug; Enzyme Inhi | 2008 |
Effects of Intrabrachial metacholine infusion on muscle capillary recruitment and forearm glucose uptake during physiological hyperinsulinemia in obese, insulin-resistant individuals.
Topics: Adult; Brachial Artery; Capillaries; Forearm; Glucose; Humans; Hyperinsulinism; Insulin; Insulin Res | 2008 |
Persistent hyperinsulinemia due to induced euglycemia in awake endotoxic minipigs.
Topics: Acid-Base Equilibrium; Animals; Blood Glucose; Blood Pressure; Blood Proteins; Endotoxins; Escherich | 1984 |
Exdotoxin-induced metabolic changes in the conscious, unrestrained rat: hypoglycemia and elevated blood lactate concentrations without hyperinsulinemia.
Topics: Animals; Blood Glucose; Endotoxins; Hyperinsulinism; Hypoglycemia; Insulin; Lactates; Lactic Acid; M | 1981 |
Effects of infused sodium lactate on glucose and energy metabolism in healthy humans.
Topics: Analysis of Variance; Basal Metabolism; Bicarbonates; Blood Glucose; Energy Metabolism; Female; Huma | 1995 |
Response of phosphoenolpyruvate cycle activity to fasting and to hyperinsulinemia in human subjects.
Topics: Fasting; Humans; Hyperinsulinism; Lactic Acid; Male; Models, Biological; Oxaloacetates; Phosphoenolp | 1996 |
Effects of hyperinsulinemia and hyperglycemia on lactate release and local blood flow in subcutaneous adipose tissue of healthy humans.
Topics: Adipose Tissue; Administration, Oral; Adult; Drinking; Glucose; Glucose Clamp Technique; Humans; Hyp | 1996 |
McArdle's disease with non-insulin-dependent diabetes mellitus: the beneficial effects of hyperglycemia and hyperinsulinemia for exercise intolerance.
Topics: Biopsy; Blood Glucose; Cerebral Infarction; Creatine Kinase; Diabetes Mellitus, Type 2; Eating; Exer | 1996 |
Glucose-lowering effect of BTS 67 582.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Glucose Tolerance Test; Guanidines; Hyperglycemia | 1997 |
Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Blood Glucose; Corticosterone; Fatty Acids, No | 1998 |
Hormonal counterregulation failure in rats is related to previous hyperglycaemia-hyperinsulinaemia.
Topics: Animals; Blood Glucose; Body Weight; Catecholamines; Eating; Female; Glucagon; Glycerol; Hyperglycem | 1998 |
Defect of an early event of glucose metabolism in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a non-insulin-dependent diabetes mellitus (NIDDM) model.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucose-6-Phosphate; Glycogen S | 1998 |
Extreme hyperinsulinemia unmasks insulin's effect to stimulate protein synthesis in the human forearm.
Topics: Adult; Blood Flow Velocity; Female; Forearm; Glucose; Humans; Hyperinsulinism; Insulin; Kinetics; La | 1998 |
Effect of physiological hyperinsulinemia on blood flow and interstitial glucose concentration in human skeletal muscle and adipose tissue studied by microdialysis.
Topics: Adipose Tissue; Adult; Female; Forearm; Glucose; Glycerol; Humans; Hyperinsulinism; Insulin; Lactic | 1998 |
Aerobic exercise during pregnancy reverts maternal insulin resistance in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Eating; Female; Fetus; Glucose Clamp Tech | 1998 |
Lactate metabolism of subcutaneous adipose tissue studied by open flow microperfusion.
Topics: Adipose Tissue; Adult; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Lactic Acid; | 1998 |
Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans.
Topics: Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Glucose; Hormones; Humans; Hyperinsulin | 1999 |
Neonatal hypoglycaemia in Nepal 2. Availability of alternative fuels.
Topics: Age Factors; Blood Glucose; Cross-Sectional Studies; Energy Metabolism; Fatty Acids, Nonesterified; | 2000 |
Metformin inhibits catecholamine-stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study.
Topics: Adipose Tissue; Adult; Body Mass Index; Electric Impedance; Epinephrine; Female; Glycerol; Humans; H | 1999 |
Antidiabetic activity of white skinned sweet potato (Ipomoea batatas L.) in obese Zucker fatty rats.
Topics: Animals; Blood Glucose; Chromans; Fatty Acids, Nonesterified; Glucose Tolerance Test; Hyperinsulinis | 2000 |
Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN.
Topics: Animals; Blood Glucose; Catheterization; Dogs; Dose-Response Relationship, Drug; Energy Metabolism; | 2000 |
Estimations of muscle interstitial insulin, glucose, and lactate in type 2 diabetic subjects.
Topics: Adult; Arteries; Blood Flow Velocity; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Ext | 2000 |
Carbohydrate depletion has profound effects on the muscle amino acid and glucose metabolism during hyperinsulinaemia.
Topics: Adult; Alanine; Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Carbohydrates; Dietary Carb | 2001 |
Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes.
Topics: Abdomen; Adipocytes; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Glucose Clamp | 2001 |
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Topics: Alanine; Animals; Blood Glucose; Dogs; Duodenum; Fructose; Glucagon; Gluconeogenesis; Glucose; Glyce | 2002 |
Insulin time-dependent effects on the leg exchange of glucose and amino acids in man.
Topics: Amino Acids; Fatty Acids, Nonesterified; Glucose; Glycerol; Humans; Hyperinsulinism; Insulin; Kineti | 1991 |
Acute and chronic effects of insulin on lactate dehydrogenase (LDH) activity in tissues of albino rat (Wistar strain).
Topics: Animals; Hyperinsulinism; Insulin; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Male; Pyruvates; | 1988 |