lactic acid has been researched along with Colorectal Neoplasms in 89 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 9.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC) owing to its potent anticancer effects." | 8.31 | 5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy. ( Bae, J; Hee Lee, E; Kim, H; Kim, J; Kim, MS; Kwak, D; Lee, J; Phyu Hlaing, S; Ryong Moon, H; Saparbayeva, A; Yoo, JW; Yoon, IS, 2023) |
| " An immunometabolic strategy for treating colorectal cancer liver metastases using the shikonin-loaded, hyaluronic acid-modified mesoporous polydopamine nanoparticles (SHK@HA-MPDA) via glycolysis inhibition, anticancer immunity activation, and EMT reversal." | 8.31 | Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. ( Chen, G; He, Y; Hou, J; Huang, Y; Lin, F; Long, L; Peng, T; Wang, R; Xiong, W; Xu, Q, 2023) |
| "To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors." | 8.02 | Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer. ( Gong, ZC; Kang, X; Liu, D; Liu, XL; Qian, J; Sheng, J; Wang, LT; Wang, W; Wu, HH; Wu, J; Xu, W; Ye, LJ; Zhang, YN; Zhao, J; Zheng, W, 2021) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 8.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| "Sorafenib has been recently used for the treatment of patients with advanced colorectal cancer (CRC) and is recognized for its therapeutic value." | 7.96 | Combination Antitumor Effect of Sorafenib via Calcium-Dependent Deactivation of Focal Adhesion Kinase Targeting Colorectal Cancer Cells. ( Jeong, KY; Kim, HM; Park, M; Sim, JJ, 2020) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 7.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| " In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 7.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
| "Lactic acid has been directly linked to the massive proliferation of cancerous cells since the glycolytic pathway provides cancerous cells with not only ATP, but also biosynthetic intermediates for rapid growth and proliferation." | 7.01 | Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment? ( Bence, RL; Bodnar, I; Budán, F; Kaposztas, Z; Macharia, JM; Varjas, T; Zand, A, 2023) |
| "69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC." | 6.87 | Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer. ( Dai, J; Peng, J; Wang, W; Wei, Y; Xia, L; Xu, H; Zhou, F, 2018) |
| " To achieve better bioavailability of antitumor drugs that were loaded in RBCm-NPs, the functionalization of coated RBCm with specific targeting ability is essential." | 5.48 | Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment. ( Hua, D; Huang, J; Liu, B; Qian, H; Qian, X; Sha, H; Yu, L; Zhang, H; Zhang, Z, 2018) |
| "Dimethilhydrazine was used to induce colorectal cancer in mice." | 5.46 | Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. ( Azevedo, V; Bermúdez-Humarán, LG; de Moreno de LeBlanc, A; Del Carmen, S; Langella, P; LeBlanc, JG; Levit, R, 2017) |
| "An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia." | 5.43 | 2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro. ( Fei, Q; Li, J; Sun, Y; Wang, F; Zhang, C; Zhang, D; Zhu, C, 2016) |
| "The role of MCTs in the survival of colorectal cancer (CRC) cells is scarce and poorly understood." | 5.42 | Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells. ( Amorim, R; Baltazar, F; Miranda-Gonçalves, V; Moyer, MP; Pereira, H; Pinheiro, C; Preto, A, 2015) |
| "Fluorouracil (FU) is a cornerstone of colorectal cancer treatment; however, it has clinical and subclinical influence on the heart." | 5.14 | Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle. ( Hasbak, P; Jensen, SA; Mortensen, J; Sørensen, JB, 2010) |
| "5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for colorectal cancer (CRC) owing to its potent anticancer effects." | 4.31 | 5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy. ( Bae, J; Hee Lee, E; Kim, H; Kim, J; Kim, MS; Kwak, D; Lee, J; Phyu Hlaing, S; Ryong Moon, H; Saparbayeva, A; Yoo, JW; Yoon, IS, 2023) |
| " An immunometabolic strategy for treating colorectal cancer liver metastases using the shikonin-loaded, hyaluronic acid-modified mesoporous polydopamine nanoparticles (SHK@HA-MPDA) via glycolysis inhibition, anticancer immunity activation, and EMT reversal." | 4.31 | Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery. ( Chen, G; He, Y; Hou, J; Huang, Y; Lin, F; Long, L; Peng, T; Wang, R; Xiong, W; Xu, Q, 2023) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 4.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| "To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors." | 4.02 | Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer. ( Gong, ZC; Kang, X; Liu, D; Liu, XL; Qian, J; Sheng, J; Wang, LT; Wang, W; Wu, HH; Wu, J; Xu, W; Ye, LJ; Zhang, YN; Zhao, J; Zheng, W, 2021) |
| "Sorafenib has been recently used for the treatment of patients with advanced colorectal cancer (CRC) and is recognized for its therapeutic value." | 3.96 | Combination Antitumor Effect of Sorafenib via Calcium-Dependent Deactivation of Focal Adhesion Kinase Targeting Colorectal Cancer Cells. ( Jeong, KY; Kim, HM; Park, M; Sim, JJ, 2020) |
| "Phytic acid (PA) has been demonstrated to have a potent anticarcinogenic activity against colorectal cancer (CRC)." | 3.88 | Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model. ( Chen, C; Cheng, L; Li, X; Liu, C; Song, Y; Yang, F, 2018) |
| " Correlation of findings with duration of hepatic pedicle clamping, postoperative markers of hepatocellular necrosis and function (aminotransferases, arterial lactate, international normalized ratio, bilirubin), and morbidity." | 3.83 | Mitochondrial bioenergetics and posthepatectomy liver dysfunction. ( Alexandrino, H; Castro E Sousa, F; Martins, MA; Palmeira, CM; Rolo, AP; Teodoro, JS; Tralhão, JG; Varela, AT, 2016) |
| " In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells." | 3.80 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. ( Duan, W; Li, L; Li, Q; Lin, J; Liu, K; Shigdar, S; Xiang, D; Yang, W, 2014) |
| "Lactic acid has been directly linked to the massive proliferation of cancerous cells since the glycolytic pathway provides cancerous cells with not only ATP, but also biosynthetic intermediates for rapid growth and proliferation." | 3.01 | Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment? ( Bence, RL; Bodnar, I; Budán, F; Kaposztas, Z; Macharia, JM; Varjas, T; Zand, A, 2023) |
| "69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC." | 2.87 | Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer. ( Dai, J; Peng, J; Wang, W; Wei, Y; Xia, L; Xu, H; Zhou, F, 2018) |
| "Colorectal cancer is a clinical condition whose treatment often involves intestinal resection." | 2.80 | Markers of Perioperative Bowel Complications in Colorectal Surgery Patients. ( Havel, E; Hyšpler, R; Kaška, M; Plíšková, L; Tichá, A; Zadák, Z; Žaloudková, L, 2015) |
| "Totally 90 inpatients with confirmed colorectal cancer by pathological diagnosis were recruited as subjects in this study." | 2.80 | [Effects of Couplet Medicines (Astragalus Membranaceus and Jiaozhen) on Intestinal Barrier in Postoperative Colorectal Cancer Patients]. ( Chen, XP; Huang, JP; Jiang, XW; Wang, QZ, 2015) |
| "Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC)." | 1.51 | ( Cao, G; Li, J; Li, Z; Shen, H; Xie, P; Yue, Z; Zang, T; Zhang, S; Zhu, Y, 2019) |
| "Colorectal cancer is the third most common malignancy worldwide, with 1." | 1.51 | Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis. ( Almuaili, D; Geoghegan, J; Hand, F; Harmon, C; Hoti, E; Houlihan, DD; Lynch, L; Mentor, K; O'Farrelly, C; Robinson, MW, 2019) |
| "Malignant tumors, such as colorectal cancer (CRC), are heterogeneous diseases characterized by distinct metabolic phenotypes." | 1.48 | Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. ( Ammar, N; Arlt, A; Diehl, K; Dinges, LA; Helm, O; Plundrich, D; Röcken, C; Schäfer, H; Sebens, S, 2018) |
| " The in vivo study revealed significant enhancement in DTX bioavailability from CS-decorated PLGA NPs with more than 4-fold increase in AUC compared to DTX solution." | 1.48 | Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability. ( Alomrani, AH; Ashour, AE; Badran, MM; Harisa, GI; Kumar, A; Yassin, AE, 2018) |
| " To achieve better bioavailability of antitumor drugs that were loaded in RBCm-NPs, the functionalization of coated RBCm with specific targeting ability is essential." | 1.48 | Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment. ( Hua, D; Huang, J; Liu, B; Qian, H; Qian, X; Sha, H; Yu, L; Zhang, H; Zhang, Z, 2018) |
| "The prognosis of colorectal cancer (CRC) is seriously affected by high intestinal mucosal permeability accompanied by increasing tumor load." | 1.48 | Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets. ( Li, TM; Liu, B; Wang, GX; Wu, YY; Zang, LQ, 2018) |
| "Dimethilhydrazine was used to induce colorectal cancer in mice." | 1.46 | Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model. ( Azevedo, V; Bermúdez-Humarán, LG; de Moreno de LeBlanc, A; Del Carmen, S; Langella, P; LeBlanc, JG; Levit, R, 2017) |
| "An increased risk of colorectal cancer is related to the development of metabolic syndromes including hyperglycemia, and hyperinsulinemia." | 1.43 | 2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro. ( Fei, Q; Li, J; Sun, Y; Wang, F; Zhang, C; Zhang, D; Zhu, C, 2016) |
| "Forty-two patients with gastric or colorectal cancer underwent chemotherapy, including FAM or FOLFOX4 regimens." | 1.42 | Biomarkers for assessing mucosal barrier dysfunction induced by chemotherapy: Identifying a rapid and simple biomarker. ( Kong, W; Li, Y; Liu, F; Ni, X; Ping, X; Shen, J; Wang, J; Yu, B, 2015) |
| "The role of MCTs in the survival of colorectal cancer (CRC) cells is scarce and poorly understood." | 1.42 | Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells. ( Amorim, R; Baltazar, F; Miranda-Gonçalves, V; Moyer, MP; Pereira, H; Pinheiro, C; Preto, A, 2015) |
| "We reported that colorectal cancer express higher levels of LDHA compared with adjacent normal tissue." | 1.42 | Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer. ( Fang, C; Hao, J; Liu, A; Wang, H; Wang, J; Wang, Z, 2015) |
| "Under normoxia, the three colorectal cancer cell lines present high rates of lactate production and can be seen as "Warburg" like cancer cells independently of substrate availability, since such profile was dominant at both high and low glucose media contents." | 1.40 | Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis. ( Abrantes, AM; Botelho, MF; Carvalho, RA; Casalta-Lopes, J; Grazina, MM; Mendes, C; Pires, S; Simões, M; Tavares, LC, 2014) |
| "Micro- and nanoparticle formulations are widely used to improve the bioavailability of low solubility drugs." | 1.40 | Docetaxel load biodegradable porous microspheres for the treatment of colorectal peritoneal carcinomatosis. ( Fan, R; Guo, G; Han, B; Luo, Y; Peng, X; Wang, Y; Wu, M; Zheng, Y; Zhou, L, 2014) |
| "MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting the PDHX, which inhibits the conversion of pyruvate to acetyl coenzyme A in the citric acid cycle." | 1.40 | MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells. ( Chen, B; Jin, X; Liang, S; Liu, J; Liu, Y; Lu, W; Xia, Z; Xu, N; Yuan, Q; Zhao, X, 2014) |
| "In addition, we established a colorectal cancer model, and detected CD147 expression in vivo." | 1.39 | Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo. ( Deng, Q; Gao, T; He, B; Li, R; Pan, Y; Song, G; Sun, H; Wang, S; Xu, Y, 2013) |
| "Representative colorectal cancer and non-cancerous cell lines were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase." | 1.36 | Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. ( Hughes, TA; Jayne, DG; Madhok, BM; Perry, SL; Yeluri, S, 2010) |
| "Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of their KRAS or BRAF genes, we found that GLUT1, encoding glucose transporter-1, was one of three genes consistently up-regulated in cells with KRAS or BRAF mutations." | 1.35 | Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. ( Angenendt, P; Cheong, I; Diaz, LA; Kinzler, KW; Lengauer, C; Markowitz, S; Pagliarini, R; Papadopoulos, N; Rago, C; Rajagopalan, H; Schmidt, K; Velculescu, VE; Vogelstein, B; Willson, JK; Yun, J; Zhou, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.12) | 18.7374 |
| 1990's | 3 (3.37) | 18.2507 |
| 2000's | 6 (6.74) | 29.6817 |
| 2010's | 57 (64.04) | 24.3611 |
| 2020's | 22 (24.72) | 2.80 |
| Authors | Studies |
|---|---|
| Ni, X | 2 |
| Feng, Y | 1 |
| Fu, X | 1 |
| Karoon Kiani, F | 1 |
| Izadi, S | 1 |
| Ansari Dezfouli, E | 1 |
| Ebrahimi, F | 1 |
| Mohammadi, M | 1 |
| Chalajour, H | 1 |
| Mortazavi Bulus, M | 1 |
| Nasr Esfahani, M | 1 |
| Karpisheh, V | 1 |
| Mahmoud Salehi Khesht, A | 1 |
| Abbaszadeh-Goudarzi, K | 1 |
| Soleimani, A | 1 |
| Gholizadeh Navashenaq, J | 1 |
| Ahmadi, M | 1 |
| Hassannia, H | 1 |
| Hojjat-Farsangi, M | 1 |
| Shahmohammadi Farid, S | 1 |
| Hashemi, V | 1 |
| Jadidi-Niaragh, F | 1 |
| Xiong, B | 1 |
| Xie, Z | 1 |
| Song, F | 1 |
| Chen, H | 1 |
| Wang, X | 3 |
| Jin, Z | 1 |
| Han, T | 1 |
| Li, Y | 3 |
| Zhang, D | 3 |
| Liu, S | 4 |
| Zhao, H | 2 |
| Hu, Y | 3 |
| Yan, C | 2 |
| Mi, Y | 1 |
| Li, X | 6 |
| Tao, D | 2 |
| Qin, J | 2 |
| Zhu, D | 1 |
| Jiang, Y | 1 |
| Cao, H | 1 |
| Yang, J | 2 |
| Shu, Y | 1 |
| Feng, H | 1 |
| Yang, X | 2 |
| Sun, X | 2 |
| Shao, M | 1 |
| Lee, J | 2 |
| Bae, J | 2 |
| Kwak, D | 2 |
| Kim, H | 2 |
| Kim, J | 2 |
| Phyu Hlaing, S | 2 |
| Saparbayeva, A | 2 |
| Hee Lee, E | 2 |
| Yoon, IS | 2 |
| Kim, MS | 2 |
| Ryong Moon, H | 2 |
| Yoo, JW | 2 |
| Gao, S | 1 |
| Zhang, X | 5 |
| Bai, W | 1 |
| Wang, J | 3 |
| Jiang, B | 2 |
| Liu, H | 1 |
| Liang, Z | 1 |
| Cheng, S | 1 |
| Huang, L | 1 |
| Li, W | 2 |
| Zhou, C | 1 |
| Zheng, X | 1 |
| Li, S | 1 |
| Zeng, Z | 1 |
| Kang, L | 1 |
| Gao, X | 2 |
| Zhou, S | 2 |
| Qin, Z | 1 |
| Li, D | 2 |
| Zhu, Y | 2 |
| Ma, D | 1 |
| Macharia, JM | 1 |
| Kaposztas, Z | 1 |
| Varjas, T | 1 |
| Budán, F | 1 |
| Zand, A | 1 |
| Bodnar, I | 1 |
| Bence, RL | 1 |
| Tong, Z | 1 |
| Shi, S | 1 |
| Hou, T | 1 |
| Gao, G | 1 |
| Shan, Y | 1 |
| Zhang, C | 2 |
| Sun, Q | 1 |
| Wu, J | 2 |
| Zhu, G | 1 |
| Li, T | 1 |
| Zhu, X | 1 |
| Ni, B | 1 |
| Xu, B | 1 |
| Ma, X | 2 |
| Li, J | 5 |
| Long, L | 1 |
| Xiong, W | 1 |
| Lin, F | 1 |
| Hou, J | 1 |
| Chen, G | 1 |
| Peng, T | 1 |
| He, Y | 1 |
| Wang, R | 2 |
| Xu, Q | 1 |
| Huang, Y | 1 |
| Guo, Y | 2 |
| Liu, J | 2 |
| Guo, F | 1 |
| Du, L | 1 |
| Yang, Y | 1 |
| Ma, Y | 2 |
| Babl, N | 1 |
| Decking, SM | 1 |
| Voll, F | 1 |
| Althammer, M | 1 |
| Sala-Hojman, A | 1 |
| Ferretti, R | 1 |
| Korf, C | 1 |
| Schmidl, C | 1 |
| Schmidleithner, L | 1 |
| Nerb, B | 1 |
| Matos, C | 1 |
| Koehl, GE | 1 |
| Siska, P | 1 |
| Bruss, C | 1 |
| Kellermeier, F | 1 |
| Dettmer, K | 1 |
| Oefner, PJ | 1 |
| Wichland, M | 1 |
| Ugele, I | 1 |
| Bohr, C | 1 |
| Herr, W | 1 |
| Ramaswamy, S | 1 |
| Heinrich, T | 1 |
| Herhaus, C | 1 |
| Kreutz, M | 1 |
| Renner, K | 1 |
| Mu, L | 1 |
| Huang, K | 1 |
| Li, Q | 2 |
| Ferreira-Lazarte, A | 1 |
| Fernández, J | 1 |
| Gallego-Lobillo, P | 1 |
| Villar, CJ | 1 |
| Lombó, F | 1 |
| Moreno, FJ | 1 |
| Villamiel, M | 1 |
| Jeong, KY | 1 |
| Park, M | 1 |
| Sim, JJ | 1 |
| Kim, HM | 2 |
| Tu, CE | 1 |
| Zhou, P | 1 |
| Guo, X | 1 |
| Gu, C | 1 |
| Zhang, Y | 1 |
| Li, A | 1 |
| Qian, J | 1 |
| Gong, ZC | 1 |
| Zhang, YN | 1 |
| Wu, HH | 1 |
| Zhao, J | 1 |
| Wang, LT | 1 |
| Ye, LJ | 1 |
| Liu, D | 1 |
| Wang, W | 2 |
| Kang, X | 1 |
| Sheng, J | 1 |
| Xu, W | 1 |
| Liu, XL | 1 |
| Zheng, W | 1 |
| Gulmez, S | 1 |
| Senger, AS | 1 |
| Uzun, O | 1 |
| Keklikkiran, ZZ | 1 |
| Bozkurt, H | 1 |
| Omeroglu, S | 1 |
| Polat, E | 1 |
| Duman, M | 1 |
| Ban, HS | 1 |
| Kim, BK | 1 |
| Lee, H | 1 |
| Harmalkar, D | 1 |
| Nam, M | 1 |
| Park, SK | 1 |
| Lee, K | 2 |
| Park, JT | 1 |
| Kim, I | 1 |
| Hwang, GS | 1 |
| Won, M | 1 |
| Xiao, Z | 1 |
| Ai, F | 1 |
| Liu, F | 2 |
| Chen, X | 1 |
| Cao, K | 1 |
| Ren, W | 1 |
| Shu, P | 1 |
| Diehl, K | 1 |
| Dinges, LA | 1 |
| Helm, O | 1 |
| Ammar, N | 1 |
| Plundrich, D | 1 |
| Arlt, A | 1 |
| Röcken, C | 1 |
| Sebens, S | 1 |
| Schäfer, H | 1 |
| Sahin, A | 1 |
| Spiroux, F | 1 |
| Guedon, I | 1 |
| Arslan, FB | 1 |
| Sarcan, ET | 1 |
| Ozkan, T | 1 |
| Colak, N | 1 |
| Yuksel, S | 1 |
| Ozdemir, S | 1 |
| Ozdemir, B | 1 |
| Akbas, S | 1 |
| Ultav, G | 1 |
| Aktas, Y | 1 |
| Capan, Y | 1 |
| Fritsche-Guenther, R | 1 |
| Zasada, C | 1 |
| Mastrobuoni, G | 1 |
| Royla, N | 1 |
| Rainer, R | 1 |
| Roßner, F | 1 |
| Pietzke, M | 1 |
| Klipp, E | 1 |
| Sers, C | 1 |
| Kempa, S | 1 |
| Zhang, S | 1 |
| Xie, P | 1 |
| Zang, T | 1 |
| Shen, H | 1 |
| Cao, G | 1 |
| Yue, Z | 1 |
| Li, Z | 1 |
| Liu, C | 2 |
| Chen, C | 1 |
| Yang, F | 1 |
| Cheng, L | 1 |
| Song, Y | 1 |
| Wu, F | 1 |
| Gao, P | 1 |
| Wu, W | 1 |
| Wang, Z | 3 |
| Di, J | 1 |
| Su, X | 1 |
| Badran, MM | 1 |
| Alomrani, AH | 1 |
| Harisa, GI | 1 |
| Ashour, AE | 1 |
| Kumar, A | 1 |
| Yassin, AE | 1 |
| Lee, SH | 1 |
| McIntyre, D | 1 |
| Honess, D | 1 |
| Hulikova, A | 1 |
| Pacheco-Torres, J | 1 |
| Cerdán, S | 1 |
| Swietach, P | 1 |
| Harris, AL | 2 |
| Griffiths, JR | 2 |
| Zhang, Z | 2 |
| Qian, H | 2 |
| Huang, J | 1 |
| Sha, H | 1 |
| Zhang, H | 1 |
| Yu, L | 2 |
| Liu, B | 3 |
| Hua, D | 1 |
| Qian, X | 2 |
| Wu, YY | 1 |
| Li, TM | 1 |
| Zang, LQ | 1 |
| Wang, GX | 1 |
| Gendler, S | 1 |
| Shmilovich, H | 1 |
| Aranovich, D | 1 |
| Nadler, R | 1 |
| Kashtan, H | 1 |
| Stein, M | 1 |
| Harmon, C | 1 |
| Robinson, MW | 1 |
| Hand, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for lactic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Targeted lactate dehydrogenase genes silencing in probiotic lactic acid bacteria: A possible paradigm shift in colorectal cancer treatment?
Topics: Colorectal Neoplasms; Glycolysis; Humans; L-Lactate Dehydrogenase; Lactic Acid; Probiotics; Tumor Mi | 2023 |
Lactate-related metabolic reprogramming and immune regulation in colorectal cancer.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glycolysis; Humans; Lactic Ac | 2022 |
Emerging roles of lactic acid bacteria in protection against colorectal cancer.
Topics: Animals; Antioxidants; Apoptosis; Colorectal Neoplasms; DNA Damage; Epigenesis, Genetic; Gene Expres | 2014 |
5 trials available for lactic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Prognostic Significance of Serum Lactic Acid, Lactate Dehydrogenase, and Albumin Levels in Patients with Metastatic Colorectal Cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; L-Lactate Dehydrogenase; L | 2018 |
[Effects of Couplet Medicines (Astragalus Membranaceus and Jiaozhen) on Intestinal Barrier in Postoperative Colorectal Cancer Patients].
Topics: Amine Oxidase (Copper-Containing); Antineoplastic Combined Chemotherapy Protocols; Astragalus propin | 2015 |
Markers of Perioperative Bowel Complications in Colorectal Surgery Patients.
Topics: Aged; Anastomotic Leak; Biomarkers; Citrulline; Colorectal Neoplasms; DNA, Bacterial; Fatty Acid-Bin | 2015 |
Fluorouracil induces myocardial ischemia with increases of plasma brain natriuretic peptide and lactic acid but without dysfunction of left ventricle.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherap | 2010 |
Changes of interleukin-6 and related factors as well as gastric intramucosal pH during colorectal and orthopaedic surgical procedures.
Topics: Adult; Aged; C-Reactive Protein; Colorectal Neoplasms; Female; Gastric Acidity Determination; Gastri | 2006 |
81 other studies available for lactic acid and Colorectal Neoplasms
| Article | Year |
|---|---|
Role of salt‑inducible kinase 2 in the malignant behavior and glycolysis of colorectal cancer cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Enzyme Activation; Gene E | 2021 |
Simultaneous silencing of the A2aR and PD-1 immune checkpoints by siRNA-loaded nanoparticles enhances the immunotherapeutic potential of dendritic cell vaccine in tumor experimental models.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Chitosan; Colorectal Neoplasms; Combined M | 2022 |
DDR1 promotes LoVo cell proliferation by regulating energy metabolism.
Topics: Bromodeoxyuridine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Diamid | 2022 |
Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation.
Topics: Cell Line; Colorectal Neoplasms; Humans; Hypoxia; Lactic Acid; Neoplastic Stem Cells; Oxidative Phos | 2022 |
Lactate: A regulator of immune microenvironment and a clinical prognosis indicator in colorectal cancer.
Topics: Colorectal Neoplasms; Humans; Lactic Acid; Neovascularization, Pathologic; Prognosis; Tumor Microenv | 2022 |
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy.
Topics: Animals; Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Conc | 2023 |
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy.
Topics: Animals; Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Conc | 2023 |
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy.
Topics: Animals; Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Conc | 2023 |
5-Fluorouracil crystal-incorporated, pH-responsive, and release-modulating PLGA/Eudragit FS hybrid microparticles for local colorectal cancer-targeted chemotherapy.
Topics: Animals; Colorectal Neoplasms; Drug Carriers; Drug Delivery Systems; Fluorouracil; Hydrogen-Ion Conc | 2023 |
Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/β-Catenin Signal Pathway.
Topics: Animals; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; HMGB3 Protein; Hu | 2023 |
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T-Cells to Activation-Induced Cell Death in Colorectal Cancer.
Topics: CD8-Positive T-Lymphocytes; Cell Death; Colorectal Neoplasms; Humans; Immune Evasion; Lactic Acid; P | 2023 |
Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colorecta | 2023 |
Development of lactate-related gene signature and prediction of overall survival and chemosensitivity in patients with colorectal cancer.
Topics: Colorectal Neoplasms; Databases, Factual; Humans; Lactic Acid; Multivariate Analysis; Mutation; Prog | 2023 |
Regulating lactate-related immunometabolism and EMT reversal for colorectal cancer liver metastases using shikonin targeted delivery.
Topics: Animals; CD8-Positive T-Lymphocytes; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Humans | 2023 |
Depicting the landscape of gut microbial-metabolic interaction and microbial-host immune heterogeneity in deficient and proficient DNA mismatch repair colorectal cancers.
Topics: CD8-Positive T-Lymphocytes; Colorectal Neoplasms; DNA Mismatch Repair; Gastrointestinal Microbiome; | 2023 |
MCT4 blockade increases the efficacy of immune checkpoint blockade.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Glycolysis; Humans; Immune Checkpoint Inhibitors; L | 2023 |
Differentiated cancer cell-originated lactate promotes the self-renewal of cancer stem cells in patient-derived colorectal cancer organoids.
Topics: Animals; Cell Differentiation; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Gene E | 2020 |
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model.
Topics: Acetates; Animals; Azoxymethane; Bifidobacterium; Blood Glucose; Body Weight; Butyrates; Carcinogene | 2021 |
Combination Antitumor Effect of Sorafenib via Calcium-Dependent Deactivation of Focal Adhesion Kinase Targeting Colorectal Cancer Cells.
Topics: Antineoplastic Agents; Calcium; Cell Cycle; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; D | 2020 |
Lactate and TGF-β antagonistically regulate inflammasome activation in the tumor microenvironment.
Topics: Colorectal Neoplasms; Culture Media, Conditioned; HCT116 Cells; Humans; Immunity, Innate; Inflammaso | 2021 |
Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer.
Topics: Animals; Bone Neoplasms; Cadherins; CD4-Positive T-Lymphocytes; Cell Adhesion; Cell Differentiation; | 2021 |
The risk factors of intraoperative hyperlactatemia in patients undergoing laparoscopic colorectal surgery.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Humans; Hyperlactatemia; Lactic Acid; | 2021 |
The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth.
Topics: Adamantane; Animals; Antineoplastic Agents; Cell Proliferation; Colorectal Neoplasms; Cyclic AMP; Fe | 2017 |
miR-142-5p promotes development of colorectal cancer through targeting SDHB and facilitating generation of aerobic glycolysis.
Topics: Apoptosis; Caco-2 Cells; Case-Control Studies; Cell Proliferation; Colorectal Neoplasms; Gene Expres | 2017 |
Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.
Topics: Apoptosis; Biopsy; Cell Line, Tumor; Cell Transformation, Neoplastic; Coculture Techniques; Colon; C | 2018 |
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu | 2017 |
Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations.
Topics: Amino Acid Substitution; AMP-Activated Protein Kinases; Animals; Caco-2 Cells; Colorectal Neoplasms; | 2018 |
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Dextran Sulfate; Diet; Dis | 2019 |
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Cadherins; Claudin-1; Colon; Colorectal Neoplasms; Cyto | 2018 |
STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Gene Ex | 2018 |
Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Survival; Chitosan; Colorectal Neoplas | 2018 |
Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.
Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase IX; Cell Hypoxia; Cell Proliferation; Colorectal Neo | 2018 |
Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomimetic Materials; Cell Line, Tumor; Cell Proliferatio | 2018 |
Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets.
Topics: Animals; Antineoplastic Agents, Phytogenic; Berberine; Colorectal Neoplasms; Dose-Response Relations | 2018 |
Urgent Laparotomy in Patients with Metastatic Colorectal Cancer Presenting as an Acute Abdomen: A Retrospective Analysis.
Topics: Abdomen, Acute; Adult; Age Factors; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Hospital | 2018 |
Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis.
Topics: Adult; Aged; Apoptosis; Biological Transport; Biomarkers; Biopsy; Cell Line, Tumor; Colorectal Neopl | 2019 |
Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome.
Topics: Amino Acid Transport System ASC; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neopla | 2019 |
B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2.
Topics: Animals; Apoptosis; B7 Antigens; Cell Proliferation; Colorectal Neoplasms; Drug Resistance, Neoplasm | 2019 |
Long Noncoding RNA LINC00265 Promotes Glycolysis and Lactate Production of Colorectal Cancer through Regulating of miR-216b-5p/TRIM44 Axis.
Topics: Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glyco | 2020 |
Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by
Topics: Acetates; Amino Acids; Biomarkers; Citrates; Colonic Polyps; Colorectal Neoplasms; Glycerol; Humans; | 2019 |
Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Breast Neoplasms; Catechin; Cell Line, Tumor | 2019 |
TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells.
Topics: Cell Proliferation; Cell Survival; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glu | 2013 |
Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo.
Topics: Antineoplastic Agents; Basigin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Col | 2013 |
Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line.
Topics: Adenocarcinoma; Caco-2 Cells; Cell Line, Tumor; Citric Acid Cycle; Coculture Techniques; Colorectal | 2013 |
Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Antineoplastic Agents; Aptamers, Nucleotide; Cell Adhes | 2014 |
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Aci | 2014 |
Docetaxel load biodegradable porous microspheres for the treatment of colorectal peritoneal carcinomatosis.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Docetaxe | 2014 |
Dichloroacetate induces autophagy in colorectal cancer cells and tumours.
Topics: Animals; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Dichl | 2014 |
MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.
Topics: Base Sequence; Binding Sites; Cell Line, Tumor; Colorectal Neoplasms; Computational Biology; Gene Ex | 2014 |
Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis.
Topics: Carbon-13 Magnetic Resonance Spectroscopy; Cell Hypoxia; Cell Line, Tumor; Colorectal Neoplasms; Glu | 2014 |
Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.
Topics: Blotting, Western; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Acid; Flow Cytometry; Gl | 2015 |
Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzoxazoles; Blotting, Western; Cell Line, Tu | 2015 |
Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Colitis; Colorectal Neoplasms | 2015 |
Biomarkers for assessing mucosal barrier dysfunction induced by chemotherapy: Identifying a rapid and simple biomarker.
Topics: Adult; Aged; Amine Oxidase (Copper-Containing); Antineoplastic Agents; Biomarkers; Citrulline; Color | 2015 |
Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; C | 2015 |
GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.
Topics: Angiogenesis Inhibitors; Animals; Benzenesulfonates; Cell Line, Tumor; Colorectal Neoplasms; Endosta | 2015 |
Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer.
Topics: 3' Untranslated Regions; Adenosine Triphosphate; Animals; Binding Sites; Cell Proliferation; Colorec | 2015 |
MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.
Topics: Aldose-Ketose Isomerases; Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Femal | 2015 |
Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression.
Topics: Amino Acid Transport System ASC; Animals; beta Catenin; Caco-2 Cells; Cell Proliferation; Colorectal | 2015 |
SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Line, Tumor; Cell P | 2015 |
Enhanced antitumor effects by docetaxel/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer.
Topics: Animals; Antimicrobial Cationic Peptides; Antineoplastic Agents; Apoptosis; Cathelicidins; Cell Line | 2015 |
2-Deoxyglucose Reverses the Promoting Effect of Insulin on Colorectal Cancer Cells In Vitro.
Topics: Adenosine Triphosphate; Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Moveme | 2016 |
Mitochondrial bioenergetics and posthepatectomy liver dysfunction.
Topics: Adenoma; Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Aspartate Ami | 2016 |
Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer.
Topics: Biosynthetic Pathways; Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplasti | 2016 |
Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.
Topics: Basigin; Biomarkers, Tumor; Colorectal Neoplasms; Glucose Transporter Type 1; Glycolysis; Humans; Im | 2016 |
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production.
Topics: Aged; Aged, 80 and over; Carcinogenesis; Cell Self Renewal; Colon; Colonic Neoplasms; Colorectal Neo | 2016 |
Anti-cancer effect of lactic acid bacteria expressing antioxidant enzymes or IL-10 in a colorectal cancer mouse model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Catalase; Colorectal Neoplasms; Disease Models, Animal | 2017 |
Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Biomimetic Materials; Cell Death; Cell Line | 2017 |
Antitumor effect of adriamycin-encapsulated nanoparticles of poly(DL-lactide-co-glycolide)-grafted dextran.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dextran | 2009 |
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neo | 2009 |
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dichloroacetic Ac | 2010 |
Therapeutic effectiveness of slow-release PLGA-oxaliplatin microsphere on human colorectal tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Delayed-Action Preparations; | 2010 |
Effect of injection site on in situ implant formation and drug release in vivo.
Topics: Animals; Antineoplastic Agents; Catheter Ablation; Cell Line, Tumor; Chemotherapy, Adjuvant; Colorec | 2010 |
Partial liver ischemia is followed by metabolic changes in the normally perfused part of the liver during reperfusion.
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; Female; Glucose; Glycerol; Humans; Ischemia; | 2010 |
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hypoxia-Ind | 2011 |
Lactate-induced IL-8 pathway in endothelial cells--letter.
Topics: Breast Neoplasms; Colorectal Neoplasms; Humans; Interleukin-8; Lactic Acid; Monocarboxylic Acid Tran | 2012 |
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation, | 2013 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain | 2003 |
[Decreasing the risk of developing colorectal carcinoma. Lactic acid forming bacteria].
Topics: Animals; Bifidobacterium; Cell Transformation, Neoplastic; Clinical Trials as Topic; Colorectal Neop | 2003 |
Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma.
Topics: Adenocarcinoma; Cell Cycle Proteins; Cell Hypoxia; Cell Proliferation; Cell Survival; Colon; Colorec | 2006 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Immunity and probiotics.
Topics: Adaptation, Physiological; Bacteria; Colorectal Neoplasms; Humans; Hypersensitivity; Immune Toleranc | 1999 |
Cell-surface fucosylation and magnetic resonance spectroscopy characterization of human malignant colorectal cells.
Topics: Amino Acids; Cell Membrane; Cell Survival; Colorectal Neoplasms; Fourier Analysis; Fucose; Humans; L | 1992 |
Oral calcium suppresses increased rectal epithelial proliferation of persons at risk of colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Calcium Carbonate; Calcium Gluconate; Cell Division; Colorectal N | 1989 |