lactic acid has been researched along with Cognition Disorders in 22 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome." | 3.88 | Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. ( Andino, NM; Rao, SSC; Rehman, A; Yu, S, 2018) |
| "Maternally inherited diabetes and deafness (MIDD) and myoencephalopathy, lactic acidosis, stroke-like episodes (MELAS) syndromes are characterized by the same A3243G mutation of mitochondrial DNA (mtDNA)." | 3.75 | Brain anomalies in maternally inherited diabetes and deafness syndrome. ( Cozzone, PJ; Felician, O; Fromont, I; Lebail, B; Lefur, Y; Mancini, J; Nicoli, F; Paquis-Flucklinger, V; Valéro, R; Vialettes, B, 2009) |
| "To investigate, in patients with Alzheimer's Disease (AD), the possible interplay linking alteration of neuronal energy metabolism, as measured via cerebrospinal fluid (CSF) lactate concentration, to severity of AD neurodegenerative processes and impairment of cognitive abilities." | 1.42 | CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease. ( Liguori, C; Marciani, MG; Pierantozzi, M; Sancesario, G; Sancesario, GM; Stefani, A, 2015) |
| "No lactic acidosis was induced by the intravenous infusion of 280 mM L-lactate." | 1.34 | Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat. ( Bullock, MR; Hamm, RJ; Harvey, HB; Holloway, R; Levasseur, JE; Rice, AC; Sun, D; Zhou, Z, 2007) |
| "The canine counterpart of senile dementia of the Alzheimer type (ccSDAT) is considered a promising model for examining behavioral, cellular and molecular processes involved in early phases of human brain aging and Alzheimer disease (AD)." | 1.33 | Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia. ( Andrade, C; Carrasco, JL; Mahy, N; Mas, E; Mascort, J; Pugliese, M, 2005) |
| "Two adolescent females presented with encephalopathy and raised venous lactate." | 1.32 | Hashimoto's encephalopathy: an unusual cause of seizures in the intensive care unit. ( Janes, SE; Santosh, B; Thomas, D; Vyas, H, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (54.55) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Foolad, F | 1 |
| Khodagholi, F | 1 |
| Nabavi, SM | 1 |
| Javan, M | 1 |
| Rao, SSC | 1 |
| Rehman, A | 1 |
| Yu, S | 1 |
| Andino, NM | 1 |
| Ye, L | 1 |
| Fu, F | 1 |
| Liu, W | 1 |
| Sun, K | 1 |
| Li, Y | 1 |
| He, J | 1 |
| Yu, X | 1 |
| Yu, P | 1 |
| Tian, J | 1 |
| Bomba, M | 1 |
| Ciavardelli, D | 1 |
| Silvestri, E | 1 |
| Canzoniero, LM | 1 |
| Lattanzio, R | 1 |
| Chiappini, P | 1 |
| Piantelli, M | 1 |
| Di Ilio, C | 1 |
| Consoli, A | 1 |
| Sensi, SL | 1 |
| Kolisnyk, B | 1 |
| Al-Onaizi, MA | 1 |
| Hirata, PH | 1 |
| Guzman, MS | 1 |
| Nikolova, S | 1 |
| Barbash, S | 1 |
| Soreq, H | 1 |
| Bartha, R | 1 |
| Prado, MA | 1 |
| Prado, VF | 1 |
| Helbok, R | 1 |
| Schiefecker, A | 1 |
| Delazer, M | 1 |
| Beer, R | 1 |
| Bodner, T | 1 |
| Pfausler, B | 1 |
| Benke, T | 1 |
| Lackner, P | 1 |
| Fischer, M | 1 |
| Sohm, F | 1 |
| Hackl, W | 1 |
| Stover, JF | 1 |
| Thomé, C | 1 |
| Humpel, C | 1 |
| Schmutzhard, E | 1 |
| Liguori, C | 1 |
| Stefani, A | 1 |
| Sancesario, G | 1 |
| Sancesario, GM | 1 |
| Marciani, MG | 1 |
| Pierantozzi, M | 1 |
| Lu, W | 1 |
| Huang, J | 1 |
| Sun, S | 1 |
| Huang, S | 1 |
| Gan, S | 1 |
| Xu, J | 1 |
| Yang, M | 1 |
| Xu, S | 1 |
| Jiang, X | 1 |
| Chien, CT | 1 |
| Jou, MJ | 1 |
| Cheng, TY | 1 |
| Yang, CH | 1 |
| Yu, TY | 1 |
| Li, PC | 1 |
| Kondziella, D | 1 |
| Danielsen, ER | 1 |
| Hansen, K | 1 |
| Thomsen, C | 1 |
| Jansen, EC | 1 |
| Arlien-Soeborg, P | 1 |
| Fromont, I | 1 |
| Nicoli, F | 1 |
| Valéro, R | 1 |
| Felician, O | 1 |
| Lebail, B | 1 |
| Lefur, Y | 1 |
| Mancini, J | 1 |
| Paquis-Flucklinger, V | 1 |
| Cozzone, PJ | 1 |
| Vialettes, B | 1 |
| Bakker, FC | 1 |
| Klijn, CJ | 1 |
| Jennekens-Schinkel, A | 1 |
| van der Tweel, I | 1 |
| van der Grond, J | 1 |
| van Huffelen, AC | 1 |
| Tulleken, CA | 1 |
| Kappelle, LJ | 1 |
| Kubesch, S | 1 |
| Bretschneider, V | 1 |
| Freudenmann, R | 1 |
| Weidenhammer, N | 1 |
| Lehmann, M | 1 |
| Spitzer, M | 1 |
| Grön, G | 1 |
| Evans, ML | 1 |
| Hopkins, D | 1 |
| Macdonald, IA | 1 |
| Amiel, SA | 1 |
| Janes, SE | 1 |
| Santosh, B | 1 |
| Thomas, D | 1 |
| Vyas, H | 1 |
| Pugliese, M | 1 |
| Carrasco, JL | 1 |
| Andrade, C | 1 |
| Mas, E | 1 |
| Mascort, J | 1 |
| Mahy, N | 1 |
| Petrovitch, H | 1 |
| White, L | 1 |
| Holloway, R | 1 |
| Zhou, Z | 1 |
| Harvey, HB | 1 |
| Levasseur, JE | 1 |
| Rice, AC | 2 |
| Sun, D | 1 |
| Hamm, RJ | 2 |
| Bullock, MR | 2 |
| Pomper, MG | 1 |
| Sacktor, N | 1 |
| Robson, MJ | 1 |
| Alston, RP | 1 |
| Deary, IJ | 1 |
| Andrews, PJ | 1 |
| Souter, MJ | 1 |
| Zsoldos, R | 1 |
| Chen, T | 1 |
| Wilson, MS | 1 |
| Alessandri, B | 1 |
| Haan, E | 1 |
| Brown, G | 1 |
| Bankier, A | 1 |
| Mitchell, D | 1 |
| Hunt, S | 1 |
| Blakey, J | 1 |
| Barnes, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impacts of Yoga and Aerobic Exercise on Neuro-cognitive Function and Symptoms in Early Psychosis - A Single-blind Randomized Controlled Clinical Trial[NCT01207219] | 140 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"measured by Letter Cancellation test Q score. The basic version of the task consists of six 52-character rows in which the target character is randomly interspersed approximately 18 times in each row. Subjects were asked to cancel the letter C and E as quickly as possible. The time to completion, number of error and omission items were recorded. A quality of search index (Q), developed by Geldmacher et al., was applied for the analysis. Q is the ratio of correct number to total number of targets multiplied by the ratio of correct number per second. Higher Q scores represent more efficient performance and better attention and concentration. Q scores could range from 0 (worst possible outcome) to 1 (best possible outcome)." (NCT01207219)
Timeframe: baseline and 12 weeks
| Intervention | Correct number per second (Mean) | |
|---|---|---|
| Baseline | 12 weeks | |
| Aerobic Exercise | 0.71 | 0.77 |
| Waitlist Control Group | 0.74 | 0.73 |
| Yoga Therapy | 0.76 | 0.84 |
PANSS total score is computed by summing the scores of positive, negative and general symptom subscores. The range of PANSS total score is from 30 to 210, range of PANSS positive and negative subscores is from 7 to 49, range of PANSS general symptoms subscore is from 16 to 112, with higher values representing worse outcome. CDS total score is computed by summing the scores of nine items of the scale. The range of CDS total score is from 0 to 27, with higher values representing worse outcome. (NCT01207219)
Timeframe: Baseline and 12 weeks
| Intervention | units on a scale (Mean) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PANSS total score-Baseline | PANSS total score-12 weeks | PANSS positive subscore-Baseline | PANSS positive subscore-12 weeks | PANSS negative subscore-Baseline | PANSS negative subscore-12 weeks | PANSS general symptoms-Baseline | PANSS general symptoms-12 weeks | CDS-Baseline | CDS-12 weeks | |
| Aerobic Exercise | 46.8 | 39.5 | 9.7 | 8.3 | 11.2 | 9.7 | 25.9 | 21.6 | 3.4 | 1.7 |
| Waitlist Control Group | 45.4 | 49.0 | 9.8 | 10.0 | 11.2 | 12.6 | 24.5 | 26.4 | 3.7 | 4.3 |
| Yoga Therapy | 46.9 | 37.4 | 9.9 | 8.4 | 11.0 | 8.7 | 26.0 | 20.3 | 3.6 | 1.7 |
Total number of corrected encoded words in the first three trials in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks
| Intervention | correctly encoded words (Mean) | |
|---|---|---|
| Baseline | 12 weeks | |
| Aerobic Exercise | 22.0 | 28.8 |
| Waitlist Control Group | 22.7 | 24.8 |
| Yoga Therapy | 22.8 | 29.5 |
The total number of correctly recalled words after short-term (10 minutes) and long-term (30 minutes) delay in the random condition of Hong Kong List Learning test. (NCT01207219)
Timeframe: baseline and 12 weeks
| Intervention | correctly recorded words (Mean) | |
|---|---|---|
| Baseline | 12 weeks | |
| Aerobic Exercise | 15.1 | 21.0 |
| Waitlist Control Group | 14.5 | 16.6 |
| Yoga Therapy | 14.9 | 19.4 |
measured by Digit Span backwards test. In this test, the subject was asked to recall a series of numbers in reverse order. The correctly recalled series were scored as 1, and the test contains 14 sequences of numbers. The range of working memory score is from 0 to 14, with higher values representing better outcome. (NCT01207219)
Timeframe: baseline and 12 weeks
| Intervention | Scores on a scale (Mean) | |
|---|---|---|
| Baseline | 12 weeks | |
| Aerobic Exercise | 6.8 | 9.4 |
| Waitlist Control Group | 7.1 | 7.7 |
| Yoga Therapy | 6.8 | 8.5 |
3 trials available for lactic acid and Cognition Disorders
| Article | Year |
|---|---|
Cognitive impairment is related to cerebral lactate in patients with carotid artery occlusion and ipsilateral transient ischemic attacks.
Topics: Adult; Aged; Aspartic Acid; Blood Flow Velocity; Brain; Carbon Dioxide; Carotid Artery Diseases; Cer | 2003 |
Aerobic endurance exercise improves executive functions in depressed patients.
Topics: Adult; Attention; Cognition Disorders; Depressive Disorder, Major; Discrimination Learning; Exercise | 2003 |
Jugular bulb oxyhemoglobin desaturation, S100beta, and neurologic and cognitive outcomes after coronary artery surgery.
Topics: Arteriosclerosis; Body Mass Index; Cognition Disorders; Coronary Artery Bypass; Coronary Vessels; Fe | 2001 |
19 other studies available for lactic acid and Cognition Disorders
| Article | Year |
|---|---|
Changes in mitochondrial function in patients with neuromyelitis optica; correlations with motor and cognitive disabilities.
Topics: Adult; Case-Control Studies; Cognition Disorders; Cytochromes c; Electron Transport Complex I; Elect | 2020 |
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Blind Loop Syndrome; Breath | 2018 |
Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
Topics: Acetylcholinesterase; Administration, Oral; Alkaloids; Amyloid beta-Peptides; Animals; Behavior, Ani | 2013 |
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diabetes Mellitus, Ex | 2013 |
Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex.
Topics: Acetylcholine; Animals; Aspartic Acid; Choice Behavior; Choline; Cholinesterase Inhibitors; Cognitio | 2013 |
Cerebral tau is elevated after aneurysmal subarachnoid haemorrhage and associated with brain metabolic distress and poor functional and cognitive long-term outcome.
Topics: Aged; Biomarkers; Brain; Cognition Disorders; Female; Follow-Up Studies; Glutamic Acid; Humans; Intr | 2015 |
CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition Disorders; | 2015 |
Changes in lactate content and monocarboxylate transporter 2 expression in Aβ₂₅₋₃₅-treated rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cognition Disorders; Disease Mod | 2015 |
Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cerebrovascular Circulation; Cognition | 2015 |
1H MR spectroscopy of gray and white matter in carbon monoxide poisoning.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Carbon Monoxide Poisoning; Choline; Cognition Disorders; Cr | 2009 |
Brain anomalies in maternally inherited diabetes and deafness syndrome.
Topics: Adult; Aged; Brain; Cerebellar Ataxia; Cognition Disorders; Deafness; Diabetes Mellitus; Diabetes Me | 2009 |
Alanine infusion during hypoglycaemia partly supports cognitive performance in healthy human subjects.
Topics: Adult; Alanine; Blood Glucose; Cognition Disorders; Glucose Clamp Technique; Hormones; Humans; Hypog | 2004 |
Hashimoto's encephalopathy: an unusual cause of seizures in the intensive care unit.
Topics: Adolescent; Autoantibodies; Brain Diseases; Cognition Disorders; Female; Glucocorticoids; Humans; In | 2004 |
Severe cognitive impairment correlates with higher cerebrospinal fluid levels of lactate and pyruvate in a canine model of senile dementia.
Topics: Aging; Alzheimer Disease; Animals; Behavior, Animal; Biomarkers; Brain Chemistry; Cerebrospinal Flui | 2005 |
Exercise and cognitive function.
Topics: Aged; Alzheimer Disease; Cognition; Cognition Disorders; Exercise; Humans; Lactic Acid; Middle Aged; | 2005 |
Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.
Topics: Adenosine Triphosphate; Animals; Brain Injuries; Cerebral Cortex; Cognition; Cognition Disorders; In | 2007 |
New techniques for imaging Human Immunodeficiency Virus associated cognitive impairment in the era of highly active antiretroviral therapy.
Topics: Antiretroviral Therapy, Highly Active; Biomarkers; Cognition Disorders; Diffusion Magnetic Resonance | 2007 |
Lactate administration attenuates cognitive deficits following traumatic brain injury.
Topics: Animals; Brain Chemistry; Brain Injuries; Cell Death; Cognition Disorders; Energy Metabolism; Hippoc | 2002 |
Severe illness caused by the products of bacterial metabolism in a child with a short gut.
Topics: Acidosis; Caproates; Child; Cognition Disorders; Consciousness Disorders; Humans; Hydroxybutyrates; | 1985 |