lactic acid has been researched along with Chemical Dependence in 12 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury." | 8.31 | Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023) |
| "When compared to cocaine exposure alone, CE exposure in ED patients with acute drug overdose was significantly associated with higher occurrence of cardiac arrest, higher mean lactate concentrations, and lower occurrence of myocardial injury." | 4.31 | Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose. ( Manini, AF; Manoochehri, O; Richardson, LD; Shastry, S, 2023) |
| "He had a history of psychoses and substance abuse." | 1.36 | Falsely elevated lactate in severe ethylene glycol intoxication. ( Rood, PP; Russcher, H; Sandberg, Y; van Daele, PL; Weige, JD; Zwaans, JJ, 2010) |
| "This group of substance abusers did show a large range in physical fitness." | 1.35 | The aerobic fitness of substance abusers voluntary participating in a rehabilitation project. ( Mamen, A; Martinsen, EW, 2009) |
| "Alcohol and drug use are common in trauma, but do not impair the predictive accuracy of admission lactate and BD in trauma outcome." | 1.33 | Lactate and base deficit in trauma: does alcohol or drug use impair their predictive accuracy? ( Dunne, JR; Napolitano, LM; Scalea, TM; Tracy, JK, 2005) |
| " In long barbital dosing (36 days), however, the metabolite level of carbohydrate was almost recovered to the non-treated level." | 1.27 | Biochemical aspects of experimental barbital dependence II: Effect on glycometabolism. ( Kakuno, K; Nakao, K; Tagashira, E; Yanaura, S, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Shastry, S | 1 |
| Manoochehri, O | 1 |
| Richardson, LD | 1 |
| Manini, AF | 1 |
| Wang, Q | 1 |
| Hu, Y | 1 |
| Wan, J | 1 |
| Dong, B | 1 |
| Sun, J | 1 |
| Jauchem, JR | 3 |
| Mamen, A | 1 |
| Martinsen, EW | 1 |
| Sandberg, Y | 1 |
| Rood, PP | 1 |
| Russcher, H | 1 |
| Zwaans, JJ | 1 |
| Weige, JD | 1 |
| van Daele, PL | 1 |
| Dunne, JR | 1 |
| Tracy, JK | 1 |
| Scalea, TM | 1 |
| Napolitano, LM | 1 |
| Yanaura, S | 1 |
| Kakuno, K | 1 |
| Nakao, K | 1 |
| Tagashira, E | 1 |
| Carelli, V | 1 |
| Barboni, P | 1 |
| Zacchini, A | 1 |
| Mancini, R | 1 |
| Monari, L | 1 |
| Cevoli, S | 1 |
| Liguori, R | 1 |
| Sensi, M | 1 |
| Lugaresi, E | 1 |
| Montagna, P | 1 |
| Balon, R | 1 |
| Jordan, M | 1 |
| Pohl, R | 1 |
| Yeragani, VK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST)[NCT02742974] | 196 participants (Anticipated) | Interventional | 2015-12-31 | Recruiting | |||
| Safety and Efficacy Study of a Single Intravitreal Injection of rAAV2-ND4 Treatment of Leber Hereditary Optic Neuropathy[NCT01267422] | 9 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01267422)
Timeframe: Up to 3 years
| Intervention | mmHg (Mean) |
|---|---|
| IOP Before Treatment | 14 |
| IOP After Treatment | 16 |
The mean of Neutralizing antibody assay of 8 patients before and after treatment (NCT01267422)
Timeframe: up to 3 years
| Intervention | titer (Mean) |
|---|---|
| The Mean of Neutralizing Antibody Assay Before Treatment | 0.9221 |
| The Mean of Neutralizing Antibody Assay After Treatment | 0.8723 |
Average RNFL thickness of 8 patients througth Optical coherence tomography(OCT) test before and after treatment (NCT01267422)
Timeframe: Up to 3 years
| Intervention | Micrometer (Mean) | |
|---|---|---|
| injected eye | uninjected eye | |
| Average RNFL Thickness After Treatment | 46.7813 | 47.9688 |
| Average RNFL Thickness Before Treatment | 47.3125 | 50.1875 |
MD: mean deviation, the value Close to 0 regarded normal.VFI/MD：The bigger one was more close to the normal value. (NCT01267422)
Timeframe: up to 3 years
| Intervention | dB (Mean) | |
|---|---|---|
| injected eye | uninjected eye | |
| Mean MD After Treatment | -23.813 | -23.427 |
| Mean MD Before Treatment | -29.377 | -28.701 |
VFI: visual field index ,the value Close to 100% regarded normal. VFI/MD：The bigger one was more close to the normal value. (NCT01267422)
Timeframe: up to 3 years
| Intervention | Percentage of normal (Mean) | |
|---|---|---|
| injected eye | uninjected eye | |
| Mean VFI After Treatment | 28 | 25 |
| Mean VFI Before Treatment | 11 | 10.5 |
The mean percentage of CD3+/CD4+/CD8+ test before and after treatment (NCT01267422)
Timeframe: up to 6 months
| Intervention | Percentage of total cells (Mean) | ||
|---|---|---|---|
| Values of CD3+ | Values of CD4+ | Values of CD8+ | |
| The Mean Percentage of CD3+/CD4+/CD8+ After Treatment | 53 | 20 | 13 |
| The Mean Percentage of CD3+/CD4+/CD8+ Before Treatment | 51 | 26 | 20 |
(NCT01267422)
Timeframe: Up to 3 years
| Intervention | logMAR (Mean) | ||||
|---|---|---|---|---|---|
| before treament | 1 months after treament | 3 months after treament | 6 months after treament | 9 months after treament | |
| BCVA of Treated Eyes | 1.69 | 1.58 | 1.38 | 1.23 | 1.27 |
| BCVA of Un-treated Eyes | 1.40 | 1.36 | 1.31 | 1.20 | 1.23 |
4 reviews available for lactic acid and Chemical Dependence
| Article | Year |
|---|---|
Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction.
Topics: Animals; Astrocytes; Brain; Glycolysis; Humans; Lactic Acid; Memory; Neuronal Plasticity; Neurons; S | 2019 |
Exposures to conducted electrical weapons (including TASER® devices): how many and for how long are acceptable?
Topics: Animals; Blood Glucose; Conducted Energy Weapon Injuries; Creatine Kinase; Delirium; Electric Stimul | 2015 |
Deaths in custody: are some due to electronic control devices (including TASER devices) or excited delirium?
Topics: Acidosis; Animals; Cause of Death; Confounding Factors, Epidemiologic; Delirium; Electroshock; Fever | 2010 |
Pathophysiologic changes due to TASER® devices versus excited delirium: potential relevance to deaths-in-custody?
Topics: Acidosis; Animals; Blood Glucose; Body Temperature; Catecholamines; Channelopathies; Conducted Energ | 2011 |
8 other studies available for lactic acid and Chemical Dependence
| Article | Year |
|---|---|
Cocaethylene cardiotoxicity in emergency department patients with acute drug overdose.
Topics: Adult; Cardiotoxicity; Cocaine; Drug Overdose; Emergency Service, Hospital; Ethanol; Heart Arrest; H | 2023 |
The aerobic fitness of substance abusers voluntary participating in a rehabilitation project.
Topics: Adult; Bicycling; Drug Users; Exercise Test; Female; Heart Rate; Humans; Lactic Acid; Male; Oxygen C | 2009 |
Falsely elevated lactate in severe ethylene glycol intoxication.
Topics: Acidosis, Lactic; Adult; Blood Gas Analysis; Diagnosis, Differential; Ethanol; Ethylene Glycol; Fals | 2010 |
Lactate and base deficit in trauma: does alcohol or drug use impair their predictive accuracy?
Topics: Acid-Base Imbalance; Adult; Age Distribution; Alcohol Drinking; Biomarkers; Cocaine-Related Disorder | 2005 |
Biochemical aspects of experimental barbital dependence II: Effect on glycometabolism.
Topics: Animals; Barbital; Barbiturates; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Glucose; Glucose-6- | 1983 |
Leber's Hereditary Optic Neuropathy (LHON) with 14484/ND6 mutation in a North African patient.
Topics: Adult; Africa, Northern; Biopsy, Needle; DNA, Mitochondrial; Electron Transport Complex IV; Humans; | 1998 |
Bone damage--more than just nukes involved.
Topics: Acidosis, Lactic; Anti-HIV Agents; Bone Resorption; HIV Infections; Humans; Lactic Acid; Life Style; | 2001 |
Family history of anxiety disorders in control subjects with lactate-induced panic attacks.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Family; Fear; Female; Humans; Lactates; Lactic Acid; | 1989 |