lactic acid has been researched along with Cerebral Hemorrhage in 29 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 7.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| " These factors (immaturity, hyperoxia, hypoxia, blood transfusions, intraventricular hemorrhage, apnea, infection, hypercarbia, hypocarbia, patent ductus arteriosus, prostaglandin synthetase inhibitors, vitamin E deficiency, lactic acidosis, prenatal complications, genetic factors) may all be present in an infant." | 4.76 | A reexamination of the role of oxygen in retrolental fibroplasia. ( Dangman, B; Lucey, JF, 1984) |
| " Reflexes disappeared, and atropine did not induce an increase in heart rate in the brain dead animals." | 3.78 | Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography. ( Andersen, G; Barklin, A; Hvas, CL; Nielsen, TK; Pedersen, M; Sørensen, JC; Tønnesen, E, 2012) |
| "Morphometric quantitation of cerebral hemorrhage and infarction and fluorometric determinations of blood and brain tissue, glucose, glycogen, lactate, adenosine triphosphate, and phosphocreatine from 16 topographic brain sites were carried out." | 3.68 | Hemorrhagic infarct conversion in experimental stroke. ( de Courten-Myers, GM; DeVoe, G; Holm, P; Kleinholz, M; Myers, RE; Schmitt, G; Wagner, KR, 1992) |
| "Cerebral blood flow (CBF, by laser Doppler flowmetry) and extracellular cortical concentrations (by microdialysis) of adenosine, inosine, xanthine, hypoxanthine, and lactate were measured together with somatosensory evoked potentials (SEP) in chloralose-anaesthetized spontaneously hypertensive rats (SHR) during relative cerebral ischemia induced by hypotensive hemorrhage." | 3.67 | Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites. ( Carlsson, S; Hagberg, H; Sandberg, M; Skarphedinsson, JO; Thorén, P, 1989) |
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 3.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| "Emodin was used as a potential therapeutic for ICH." | 1.56 | Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches. ( Cai, E; Lin, L; Liu, Y; Nie, B; Tian, Q; Wang, J; Xu, F; Yang, S; Zeng, P, 2020) |
| "While the management of primary intracerebral hemorrhage (ICH) remains controversial, there remains a subset of patients that undergo clot evacuation." | 1.35 | Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage. ( Ang, BT; Ho, CL; Lee, KK; Ng, I; Wang, E, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, H | 1 |
| Wang, S | 1 |
| Lang, L | 1 |
| Yang, C | 1 |
| Liu, Y | 1 |
| Yang, S | 1 |
| Cai, E | 1 |
| Lin, L | 1 |
| Zeng, P | 1 |
| Nie, B | 1 |
| Xu, F | 1 |
| Tian, Q | 1 |
| Wang, J | 1 |
| Kong, LL | 1 |
| Gao, L | 1 |
| Wang, KX | 1 |
| Liu, NN | 1 |
| Liu, CD | 1 |
| Ma, GD | 1 |
| Yang, HG | 1 |
| Qin, XM | 1 |
| Du, GH | 1 |
| Zhu, HT | 1 |
| Bian, C | 1 |
| Yuan, JC | 1 |
| Liao, XJ | 1 |
| Liu, W | 1 |
| Zhu, G | 1 |
| Feng, H | 1 |
| Lin, JK | 1 |
| Stark, MJ | 1 |
| Hodyl, NA | 1 |
| Belegar V, KK | 1 |
| Andersen, CC | 1 |
| Bao, CL | 1 |
| Dong, HS | 1 |
| Wang, E | 2 |
| Ho, CL | 2 |
| Lee, KK | 2 |
| Ng, I | 2 |
| Ang, BT | 2 |
| Awasthi, V | 1 |
| Agashe, H | 1 |
| Doblas, S | 1 |
| Towner, R | 1 |
| Balaban'ian, VIu | 1 |
| Solev, IN | 1 |
| Elizarova, OS | 1 |
| Garibova, TL | 1 |
| Litvinova, SA | 1 |
| Voronina, TA | 1 |
| Santos, E | 1 |
| Orakcioglu, B | 1 |
| Kentar, MM | 1 |
| Diedler, J | 1 |
| Uozumi, Y | 1 |
| Schöll, M | 1 |
| Unterberg, A | 1 |
| Sakowitz, OW | 1 |
| Hvas, CL | 1 |
| Nielsen, TK | 1 |
| Barklin, A | 1 |
| Sørensen, JC | 1 |
| Pedersen, M | 1 |
| Andersen, G | 1 |
| Tønnesen, E | 1 |
| Chiang, MF | 1 |
| Chiu, WT | 1 |
| Lin, FJ | 1 |
| Thajeb, P | 1 |
| Huang, CJ | 1 |
| Tsai, SH | 1 |
| Nilsson, OG | 1 |
| Polito, A | 1 |
| Säveland, H | 1 |
| Ungerstedt, U | 1 |
| Nordström, CH | 1 |
| Miller, CM | 1 |
| Vespa, PM | 1 |
| McArthur, DL | 1 |
| Hirt, D | 1 |
| Etchepare, M | 1 |
| Katayama, Y | 1 |
| Lucey, JF | 1 |
| Dangman, B | 1 |
| Mun-Bryce, S | 1 |
| Kroh, FO | 1 |
| White, J | 1 |
| Rosenberg, GA | 1 |
| Yuan, XQ | 1 |
| Wade, CE | 1 |
| Toft, PB | 1 |
| Leth, H | 1 |
| Peitersen, B | 1 |
| Lou, HC | 1 |
| Lee, EJ | 3 |
| Hung, YC | 3 |
| Lee, MY | 2 |
| Carhuapoma, JR | 1 |
| Wang, PY | 1 |
| Beauchamp, NJ | 1 |
| Keyl, PM | 1 |
| Hanley, DF | 1 |
| Barker, PB | 1 |
| Demaerel, P | 1 |
| Wilms, G | 1 |
| Robberecht, W | 1 |
| Johannik, K | 1 |
| Van Hecke, P | 1 |
| Carton, H | 1 |
| Baert, AL | 1 |
| de Courten-Myers, GM | 1 |
| Kleinholz, M | 1 |
| Holm, P | 1 |
| DeVoe, G | 1 |
| Schmitt, G | 1 |
| Wagner, KR | 1 |
| Myers, RE | 1 |
| Skarphedinsson, JO | 1 |
| Sandberg, M | 1 |
| Hagberg, H | 1 |
| Carlsson, S | 1 |
| Thorén, P | 1 |
| Plotnikov, MB | 1 |
| Plotnikova, TM | 1 |
| Iakimova, TV | 1 |
| Saratikov, AS | 1 |
| McIntosh, TK | 1 |
| Faden, AI | 1 |
| Bendall, MR | 1 |
| Vink, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage[NCT01689402] | 60 participants (Actual) | Observational | 2012-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Cerebral Hemorrhage
| Article | Year |
|---|---|
A reexamination of the role of oxygen in retrolental fibroplasia.
Topics: Anencephaly; Apnea; Carbon Dioxide; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Exchange Transfu | 1984 |
3 trials available for lactic acid and Cerebral Hemorrhage
| Article | Year |
|---|---|
Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
Topics: Adult; Aged; Analysis of Variance; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Female; Glutam | 2008 |
Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios.
Topics: Brain; Cerebral Angiography; Cerebral Hemorrhage; Cerebral Ventricles; Female; Glutamic Acid; Humans | 2007 |
Metabolic changes in the striatum after germinal matrix hemorrhage in the preterm infant.
Topics: Cell Count; Cerebral Hemorrhage; Corpus Striatum; Follow-Up Studies; Functional Laterality; Glycolys | 1997 |
25 other studies available for lactic acid and Cerebral Hemorrhage
| Article | Year |
|---|---|
Association of Cerebrospinal Fluid Biomarkers with Submental and Cerebral Hemorrhage: A Case-Control Study.
Topics: Biomarkers; Case-Control Studies; Cerebral Hemorrhage; Humans; Lactic Acid; Retrospective Studies; S | 2023 |
Functions of lactate in the brain of rat with intracerebral hemorrhage evaluated with MRI/MRS and in vitro approaches.
Topics: Animals; Cerebral Hemorrhage; Disease Models, Animal; Emodin; Lactic Acid; Magnetic Resonance Spectr | 2020 |
Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.
Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain; Cerebral Hemorrhage; Embolic Stroke; Flavanones; La | 2021 |
Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.
Topics: Altitude; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Glutamic Acid; Hyperbaric Oxygenation; L | 2015 |
Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns.
Topics: Brain; Carotid Artery, Internal; Cerebral Hemorrhage; Chorioamnionitis; Extraction, Obstetrical; Fem | 2016 |
[Effect of scalp-acupuncture on energy metabolism of brain tissue in intracerebral hemorrhage rats].
Topics: Acupuncture; Animals; Brain; Cerebral Hemorrhage; Energy Metabolism; Lactic Acid; Male; Mitochondria | 2008 |
Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Blood Pressure; Brain; Brain Chemistry; Cerebr | 2008 |
Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid.
Topics: Animals; Aspartic Acid; Brain; Cerebral Hemorrhage; Drug Compounding; Energy Metabolism; Feasibility | 2010 |
[Neuroprotector effect of human recombinant erythropoietin sorbed on polymer nanoparticles studied on model of intracerebral post-traumatic hematoma (hemorrhagic stroke)].
Topics: Adsorption; Amnesia; Animals; Cerebral Hemorrhage; Disease Models, Animal; Enbucrilate; Erythropoiet | 2011 |
Pressure reactivity index correlates with metabolic dysfunction in a porcine model of intracerebral hemorrhage.
Topics: Animals; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; G | 2012 |
Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography.
Topics: Animals; Arterial Pressure; Atropine; Blood Gas Analysis; Brain Death; Cardiac Output; Cerebral Angi | 2012 |
Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: correlation with hemodynamics and outcome.
Topics: Adult; Aged; Amino Acids; Carbohydrates; Cerebral Hemorrhage; Cerebrospinal Fluid; Cerebrovascular C | 2006 |
Are primary supratentorial intracerebral hemorrhages surrounded by a biochemical penumbra? A microdialysis study.
Topics: Adult; Aged; Cerebral Hemorrhage; Excitatory Amino Acids; Female; Glucose; Humans; Lactic Acid; Male | 2006 |
[Studies on pathogenesis of cerebral edema due to experimental cerebral hemorrhage. An approach through energy metabolism (author's transl)].
Topics: Adenosine Monophosphate; Animals; Body Water; Brain; Brain Edema; Cerebral Hemorrhage; Cyclic AMP; E | 1982 |
Brain lactate and pH dissociation in edema: 1H- and 31P-NMR in collagenase-induced hemorrhage in rats.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Hydrogen-Ion Concentration; Lactates | 1993 |
Lactated Ringer's solution alleviates brain trauma-precipitated lactic acidosis in hemorrhagic shock.
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain Injuries; Cerebral Hemorrhage; Gases; Hydrogen-Ion C | 1993 |
Anemic hypoxia in moderate intracerebral hemorrhage: the alterations of cerebral hemodynamics and brain metabolism.
Topics: Anemia; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrov | 1999 |
Early alterations in cerebral hemodynamics, brain metabolism, and blood-brain barrier permeability in experimental intracerebral hemorrhage.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Blood-Brain Barrier; Brain; Cerebral Hemorrhage; Dogs; | 1999 |
Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Brain; Cerebral Hemorrhage; Cohort Studies; Diffusion; Feasibility S | 2000 |
Marked anemic hypoxia deteriorates cerebral hemodynamics and brain metabolism during massive intracerebral hemorrhage.
Topics: Anemia; Animals; Blood Pressure; Brain; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Mo | 2001 |
MRI of herpes simplex encephalitis.
Topics: Adult; Aspartic Acid; Brain; Cerebral Cortex; Cerebral Hemorrhage; Choline; Encephalitis; Female; He | 1992 |
Hemorrhagic infarct conversion in experimental stroke.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cats; Cerebral Arteries; Ce | 1992 |
Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites.
Topics: Adenosine; Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Extrace | 1989 |
[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage].
Topics: Animals; Brain; Brain Edema; Carbohydrate Metabolism; Cats; Cerebral Hemorrhage; Cerebrovascular Cir | 1988 |
Traumatic brain injury in the rat: alterations in brain lactate and pH as characterized by 1H and 31P nuclear magnetic resonance.
Topics: Animals; Brain; Brain Injuries; Cerebral Hemorrhage; Hemodynamics; Hydrogen-Ion Concentration; Intra | 1987 |