lactic acid has been researched along with Central Retinal Edema, Cystoid in 3 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This article describes the development and characterization of PLGA nanoparticles of dexamethasone (DEX), hydrocortisone acetate (HA), and prednisolone acetate (PA) suspended in thermosensitive gels indicated for the treatment of macular edema (ME)." | 3.76 | Novel nanoparticulate gel formulations of steroids for the treatment of macular edema. ( Boddu, SH; Earla, R; Jwala, J; Karla, PK; Mitra, AK; Pal, D; Vaishya, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boddu, SH | 1 |
| Jwala, J | 1 |
| Vaishya, R | 1 |
| Earla, R | 1 |
| Karla, PK | 1 |
| Pal, D | 1 |
| Mitra, AK | 1 |
| Cardillo, JA | 1 |
| Souza-Filho, AA | 1 |
| Oliveira, AG | 1 |
| Kuppermann, BD | 1 |
| Blumenkranz, MS | 1 |
| Haller, JA | 1 |
| Williams, GA | 1 |
| Weinberg, DV | 1 |
| Chou, C | 1 |
| Whitcup, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Research Study in Patients With Persistent Macular Edema Due to Diabetic Retinopathy, Retinal Vein Occlusion, Uveitis, or Irvine-Gass Syndrome[NCT00035906] | Phase 2 | 315 participants (Actual) | Interventional | 2001-10-31 | Completed | ||
| Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma[NCT01471054] | Phase 2 | 6 participants (Actual) | Interventional | 2014-04-30 | Terminated (stopped due to Could not enroll enough patients.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Increase or decrease in central subfield retinal thickness in microns based on spectral-domain optical coherence tomography measurement (NCT01471054)
Timeframe: At 12 months
| Intervention | micron (Median) |
|---|---|
| Ozurdex | -120 |
| Bevacizumab | -4 |
Development of visually-significant lens opacity based on judgement of examining physician. (NCT01471054)
Timeframe: At 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ozurdex | 3 |
| Bevacizumab | 0 |
Intraocular pressure more than 21 mm Hg as measured with applanation tonometry. (NCT01471054)
Timeframe: At 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ozurdex | 3 |
| Bevacizumab | 0 |
Development of rhegmatogenous retinal detachment in the study eye. (NCT01471054)
Timeframe: At 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ozurdex | 0 |
| Bevacizumab | 0 |
Development of hemorrhage in the vitreous cavity detectable with slit lamp examination or dilated funduscopy. (NCT01471054)
Timeframe: At 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ozurdex | 0 |
| Bevacizumab | 0 |
The number of participants that developed 2 or more lines of visual acuity improvement in the study eye. Visual acuity was measured with Snellen eye chart placed 10 feet away from the patient. (NCT01471054)
Timeframe: At 12 months
| Intervention | participants (Number) |
|---|---|
| Ozurdex | 2 |
| Bevacizumab | 0 |
1 trial available for lactic acid and Central Retinal Edema, Cystoid
| Article | Year |
|---|---|
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met | 2007 |
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met | 2007 |
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met | 2007 |
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biocompatible Materials; Dexamethasone; Double-Blind Met | 2007 |
2 other studies available for lactic acid and Central Retinal Edema, Cystoid
| Article | Year |
|---|---|
Novel nanoparticulate gel formulations of steroids for the treatment of macular edema.
Topics: Animals; Delayed-Action Preparations; Dexamethasone; Dialysis; Emulsions; Gels; Glucocorticoids; Hyd | 2010 |
Intravitreal Bioerudivel sustained-release triamcinolone microspheres system (RETAAC). Preliminary report of its potential usefulnes for the treatment of diabetic macular edema.
Topics: Anti-Inflammatory Agents; Delayed-Action Preparations; Diabetes Complications; Drug Evaluation; Glyc | 2006 |