lactic acid has been researched along with Cell Transformation, Neoplastic in 74 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nutrient demands of cancer cannot be met by normal cell metabolism." | 2.52 | Sirtuins and the Metabolic Hurdles in Cancer. ( German, NJ; Haigis, MC, 2015) |
| "MCT4 and Cav-1 are also breast cancer prognostic biomarkers." | 2.50 | Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. ( Lisanti, MP; Martinez-Outschoorn, U; Sotgia, F, 2014) |
| " Their efficacy has been tested in tumor xenografted mice and considerable experimental findings have stimulated researchers to further improve the bioavailability of these nutraceuticals." | 2.50 | Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets. ( Aras, A; Farooqi, AA; Hechenleitner, AA; Khokhar, AR; Pineda, EA; Qureshi, MZ; Silva, MF; Sobczak-Kupiec, A, 2014) |
| "Given its pleiotropic effects on cancer biology, PKM2 represents an attractive target for cancer therapy." | 2.48 | Emerging roles of PKM2 in cell metabolism and cancer progression. ( Luo, W; Semenza, GL, 2012) |
| "Low lactate tumors ( | 2.42 | Lactate: mirror and motor of tumor malignancy. ( Mueller-Klieser, WF; Walenta, S, 2004) |
| "Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive." | 1.91 | A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch. ( Ahmad, M; Chen, C; He, Q; Hu, Y; Li, J; Lin, Y; Luo, H; Luo, Y; Sun, Y; Wang, B; Wu, D; Yang, Z; Zheng, L, 2023) |
| "Individuals with hepatocellular carcinoma who responded to anti-PD-1 treatment have lower levels of MOESIN lactylation in Treg cells than nonresponding individuals." | 1.72 | Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells. ( Chen, Q; Gao, J; Gu, J; Li, X; Liang, Y; Lu, L; Shao, Q; Wang, Q; Wei, S; Xu, X; Zhou, B; Zhou, H; Zhou, J, 2022) |
| "SLC1A3 was found to be overexpressed in gastric cancer, and this overexpression was associated with poor prognosis." | 1.56 | SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway. ( Awaleh Moumin, F; Cai, J; Chen, J; Chen, X; Jia, L; Xu, L, 2020) |
| "Malignant tumors, such as colorectal cancer (CRC), are heterogeneous diseases characterized by distinct metabolic phenotypes." | 1.48 | Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. ( Ammar, N; Arlt, A; Diehl, K; Dinges, LA; Helm, O; Plundrich, D; Röcken, C; Schäfer, H; Sebens, S, 2018) |
| "Three ovarian cancer cell lines, HEY, SKOV3, and IGROV-1, were assayed for glutamine dependence by analyzing cytotoxicity, cell cycle progression, apoptosis, cell stress, and glucose/glutamine metabolism." | 1.42 | Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway. ( Bae-Jump, VL; Guo, H; Jones, HM; Roque, DR; Sheng, X; Stine, JE; Willson, AK; Yuan, L; Zhou, C, 2015) |
| "An altered metabolism during ovarian cancer progression allows for increased macromolecular synthesis and unrestrained growth." | 1.40 | Ovarian tumor-initiating cells display a flexible metabolism. ( Anderson, AS; Frisard, MI; Hulver, MW; Roberts, PC; Schmelz, EM, 2014) |
| "Withaferin A (WA) is a bioactive compound derived from Withania somnifera." | 1.39 | Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. ( Li, W; Zhao, Y, 2013) |
| "Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts." | 1.38 | Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. ( Ando', S; Aquila, S; Casimiro, MC; Guido, C; Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Sotgia, F; Whitaker-Menezes, D; Zimmers, TA, 2012) |
| "Its promoter was hypermethylated in gastric cancer cell lines (57%, 4/7) and gastric carcinomas (33%, 33/101)." | 1.36 | Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis. ( Chan, FK; Cheng, AS; Jin, HC; Lam, EK; Liu, X; Shin, VY; Sung, JJ; Wang, X; Yu, J; Zhang, J, 2010) |
| "Necrosis was present histologically in four of the five meningiomas classified either as atypical or papillary." | 1.30 | Noninvasive evaluation of the malignant potential of intracranial meningiomas performed using proton magnetic resonance spectroscopy. ( Handa, J; Inubushi, T; Matsuda, M; Morikawa, S; Nakasu, S; Shino, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (6.76) | 18.7374 |
| 1990's | 6 (8.11) | 18.2507 |
| 2000's | 12 (16.22) | 29.6817 |
| 2010's | 38 (51.35) | 24.3611 |
| 2020's | 13 (17.57) | 2.80 |
| Authors | Studies |
|---|---|
| Man, CH | 1 |
| Mercier, FE | 1 |
| Liu, N | 1 |
| Dong, W | 1 |
| Stephanopoulos, G | 1 |
| Jiang, L | 1 |
| Jung, Y | 1 |
| Lin, CP | 1 |
| Leung, AYH | 1 |
| Scadden, DT | 1 |
| Pan, L | 1 |
| Feng, F | 1 |
| Wu, J | 3 |
| Fan, S | 1 |
| Han, J | 1 |
| Wang, S | 1 |
| Yang, L | 2 |
| Liu, W | 1 |
| Wang, C | 2 |
| Xu, K | 1 |
| Gu, J | 1 |
| Zhou, J | 1 |
| Chen, Q | 1 |
| Xu, X | 1 |
| Gao, J | 1 |
| Li, X | 2 |
| Shao, Q | 1 |
| Zhou, B | 1 |
| Zhou, H | 1 |
| Wei, S | 1 |
| Wang, Q | 1 |
| Liang, Y | 1 |
| Lu, L | 1 |
| Gao, X | 1 |
| Zhou, S | 1 |
| Qin, Z | 1 |
| Li, D | 1 |
| Zhu, Y | 1 |
| Ma, D | 1 |
| Sun, Q | 1 |
| Zhu, G | 1 |
| Li, T | 1 |
| Zhu, X | 1 |
| Ni, B | 1 |
| Xu, B | 1 |
| Ma, X | 2 |
| Li, J | 4 |
| Wang, T | 1 |
| Ye, Z | 1 |
| Li, Z | 2 |
| Jing, DS | 1 |
| Fan, GX | 1 |
| Liu, MQ | 1 |
| Zhuo, QF | 1 |
| Ji, SR | 1 |
| Yu, XJ | 1 |
| Xu, XW | 1 |
| Qin, Y | 1 |
| Sun, Y | 1 |
| He, Q | 1 |
| Yang, Z | 1 |
| Ahmad, M | 1 |
| Lin, Y | 1 |
| Wu, D | 1 |
| Zheng, L | 1 |
| Wang, B | 1 |
| Chen, C | 1 |
| Hu, Y | 1 |
| Luo, H | 1 |
| Luo, Y | 1 |
| Bhagat, TD | 1 |
| Von Ahrens, D | 1 |
| Dawlaty, M | 1 |
| Zou, Y | 2 |
| Baddour, J | 1 |
| Achreja, A | 1 |
| Zhao, H | 1 |
| Patel, B | 1 |
| Kwak, C | 1 |
| Choudhary, GS | 1 |
| Gordon-Mitchell, S | 1 |
| Aluri, S | 1 |
| Bhattacharyya, S | 1 |
| Sahu, S | 1 |
| Bhagat, P | 1 |
| Yu, Y | 1 |
| Bartenstein, M | 1 |
| Giricz, O | 1 |
| Suzuki, M | 1 |
| Sohal, D | 1 |
| Gupta, S | 1 |
| Guerrero, PA | 1 |
| Batra, S | 1 |
| Goggins, M | 1 |
| Steidl, U | 1 |
| Greally, J | 1 |
| Agarwal, B | 1 |
| Pradhan, K | 1 |
| Banerjee, D | 1 |
| Nagrath, D | 1 |
| Maitra, A | 1 |
| Verma, A | 1 |
| Sheng, Y | 1 |
| Jiang, Q | 1 |
| Dong, X | 1 |
| Liu, J | 1 |
| Liu, L | 1 |
| Wang, H | 1 |
| Wang, L | 2 |
| Li, H | 2 |
| Yang, X | 1 |
| Dong, J | 1 |
| Yuan, Y | 1 |
| Sun, L | 1 |
| Wang, X | 3 |
| Chen, J | 3 |
| Jia, M | 1 |
| Sa, H | 1 |
| Cai, Y | 1 |
| Xu, Y | 1 |
| Sun, C | 1 |
| Guo, Y | 2 |
| Ma, K | 1 |
| Gándara, L | 1 |
| Durrieu, L | 1 |
| Behrensen, C | 1 |
| Wappner, P | 1 |
| Mendes, C | 1 |
| Serpa, J | 1 |
| Lee, S | 1 |
| Jo, G | 1 |
| Jung, JS | 1 |
| Yang, DH | 1 |
| Hyun, H | 1 |
| Xu, L | 1 |
| Jia, L | 1 |
| Chen, X | 3 |
| Awaleh Moumin, F | 1 |
| Cai, J | 1 |
| Broadfield, LA | 1 |
| Duarte, JAG | 1 |
| Schmieder, R | 1 |
| Broekaert, D | 1 |
| Veys, K | 1 |
| Planque, M | 1 |
| Vriens, K | 1 |
| Karasawa, Y | 1 |
| Napolitano, F | 1 |
| Fujita, S | 1 |
| Fujii, M | 1 |
| Eto, M | 1 |
| Holvoet, B | 1 |
| Vangoitsenhoven, R | 1 |
| Fernandez-Garcia, J | 1 |
| Van Elsen, J | 1 |
| Dehairs, J | 1 |
| Zeng, J | 1 |
| Dooley, J | 1 |
| Rubio, RA | 1 |
| van Pelt, J | 1 |
| Grünewald, TGP | 1 |
| Liston, A | 1 |
| Mathieu, C | 1 |
| Deroose, CM | 1 |
| Swinnen, JV | 1 |
| Lambrechts, D | 1 |
| di Bernardo, D | 1 |
| Kuroda, S | 1 |
| De Bock, K | 1 |
| Fendt, SM | 1 |
| Zhou, C | 2 |
| Li, L | 1 |
| Wang, Y | 2 |
| Xing, Y | 1 |
| Fu, J | 1 |
| Yao, B | 1 |
| Chang, B | 1 |
| Zhao, P | 1 |
| Kon, S | 1 |
| Ishibashi, K | 1 |
| Katoh, H | 1 |
| Kitamoto, S | 1 |
| Shirai, T | 1 |
| Tanaka, S | 1 |
| Kajita, M | 1 |
| Ishikawa, S | 1 |
| Yamauchi, H | 1 |
| Yako, Y | 1 |
| Kamasaki, T | 1 |
| Matsumoto, T | 1 |
| Watanabe, H | 1 |
| Egami, R | 1 |
| Sasaki, A | 1 |
| Nishikawa, A | 1 |
| Kameda, I | 1 |
| Maruyama, T | 1 |
| Narumi, R | 1 |
| Morita, T | 1 |
| Sasaki, Y | 1 |
| Enoki, R | 1 |
| Honma, S | 1 |
| Imamura, H | 1 |
| Oshima, M | 1 |
| Soga, T | 1 |
| Miyazaki, JI | 1 |
| Duchen, MR | 1 |
| Nam, JM | 1 |
| Onodera, Y | 1 |
| Yoshioka, S | 1 |
| Kikuta, J | 1 |
| Ishii, M | 1 |
| Imajo, M | 1 |
| Nishida, E | 1 |
| Fujioka, Y | 1 |
| Ohba, Y | 1 |
| Sato, T | 1 |
| Fujita, Y | 1 |
| Diehl, K | 1 |
| Dinges, LA | 1 |
| Helm, O | 1 |
| Ammar, N | 1 |
| Plundrich, D | 1 |
| Arlt, A | 1 |
| Röcken, C | 1 |
| Sebens, S | 1 |
| Schäfer, H | 1 |
| Chen, H | 1 |
| Gao, S | 1 |
| Cheng, C | 1 |
| Apicella, M | 1 |
| Giannoni, E | 1 |
| Fiore, S | 1 |
| Ferrari, KJ | 1 |
| Fernández-Pérez, D | 1 |
| Isella, C | 1 |
| Granchi, C | 1 |
| Minutolo, F | 1 |
| Sottile, A | 1 |
| Comoglio, PM | 1 |
| Medico, E | 1 |
| Pietrantonio, F | 1 |
| Volante, M | 1 |
| Pasini, D | 1 |
| Chiarugi, P | 1 |
| Giordano, S | 1 |
| Corso, S | 1 |
| Feng, R | 1 |
| Morine, Y | 1 |
| Ikemoto, T | 1 |
| Imura, S | 1 |
| Iwahashi, S | 1 |
| Saito, Y | 1 |
| Shimada, M | 1 |
| Updegraff, BL | 1 |
| Zhou, X | 1 |
| Padanad, MS | 1 |
| Chen, PH | 1 |
| Yang, C | 2 |
| Sudderth, J | 1 |
| Rodriguez-Tirado, C | 1 |
| Girard, L | 1 |
| Minna, JD | 1 |
| Mishra, P | 1 |
| DeBerardinis, RJ | 1 |
| O'Donnell, KA | 1 |
| Rai, A | 1 |
| Greening, DW | 1 |
| Chen, M | 1 |
| Xu, R | 1 |
| Ji, H | 1 |
| Simpson, RJ | 1 |
| Schwörer, S | 1 |
| Vardhana, SA | 1 |
| Thompson, CB | 1 |
| Zheng, W | 1 |
| Tayyari, F | 1 |
| Gowda, GA | 1 |
| Raftery, D | 1 |
| McLamore, ES | 1 |
| Porterfield, DM | 1 |
| Donkin, SS | 1 |
| Bequette, B | 1 |
| Teegarden, D | 1 |
| Hipp, NI | 1 |
| Christner, L | 1 |
| Wirth, T | 1 |
| Mueller-Klieser, W | 2 |
| Walenta, S | 2 |
| Schröck, E | 1 |
| Debatin, KM | 1 |
| Beltinger, C | 1 |
| Doherty, JR | 1 |
| Scott, KE | 1 |
| Cameron, MD | 1 |
| Fallahi, M | 1 |
| Li, W | 2 |
| Hall, MA | 1 |
| Amelio, AL | 1 |
| Mishra, JK | 1 |
| Li, F | 1 |
| Tortosa, M | 1 |
| Genau, HM | 1 |
| Rounbehler, RJ | 1 |
| Lu, Y | 2 |
| Dang, CV | 1 |
| Kumar, KG | 1 |
| Butler, AA | 1 |
| Bannister, TD | 1 |
| Hooper, AT | 1 |
| Unsal-Kacmaz, K | 1 |
| Roush, WR | 1 |
| Cleveland, JL | 1 |
| Li, G | 1 |
| Mao, F | 1 |
| Liu, Q | 1 |
| Chen, L | 1 |
| Lv, L | 1 |
| Dai, W | 1 |
| Wang, G | 1 |
| Zhao, E | 1 |
| Tang, KF | 1 |
| Sun, ZS | 1 |
| Martinez-Outschoorn, U | 2 |
| Sotgia, F | 3 |
| Lisanti, MP | 3 |
| Aras, A | 1 |
| Khokhar, AR | 1 |
| Qureshi, MZ | 1 |
| Silva, MF | 1 |
| Sobczak-Kupiec, A | 1 |
| Pineda, EA | 1 |
| Hechenleitner, AA | 1 |
| Farooqi, AA | 1 |
| Bi, P | 1 |
| Burcham, G | 1 |
| Elzey, BD | 1 |
| Ratliff, T | 1 |
| Konieczny, SF | 1 |
| Ahmad, N | 1 |
| Kuang, S | 1 |
| Liu, X | 2 |
| Anderson, AS | 1 |
| Roberts, PC | 1 |
| Frisard, MI | 1 |
| Hulver, MW | 1 |
| Schmelz, EM | 1 |
| Campbell, DF | 1 |
| Saenz, R | 1 |
| Bharati, IS | 1 |
| Seible, D | 1 |
| Zhang, L | 2 |
| Esener, S | 1 |
| Messmer, B | 1 |
| Larsson, M | 1 |
| Messmer, D | 1 |
| Yuan, L | 1 |
| Sheng, X | 1 |
| Willson, AK | 1 |
| Roque, DR | 1 |
| Stine, JE | 1 |
| Guo, H | 1 |
| Jones, HM | 1 |
| Bae-Jump, VL | 1 |
| Peng, C | 1 |
| Su, J | 1 |
| Zeng, W | 1 |
| Zhang, X | 1 |
| German, NJ | 1 |
| Haigis, MC | 1 |
| Walker, CM | 1 |
| Chen, Y | 1 |
| Lai, SY | 1 |
| Bankson, JA | 1 |
| Peruzzo, P | 1 |
| Comelli, M | 1 |
| Di Giorgio, E | 1 |
| Franforte, E | 1 |
| Mavelli, I | 1 |
| Brancolini, C | 1 |
| Calamita, P | 1 |
| Miluzio, A | 1 |
| Russo, A | 1 |
| Pesce, E | 1 |
| Ricciardi, S | 1 |
| Khanim, F | 1 |
| Cheroni, C | 1 |
| Alfieri, R | 1 |
| Mancino, M | 1 |
| Gorrini, C | 1 |
| Rossetti, G | 1 |
| Peluso, I | 1 |
| Pagani, M | 1 |
| Medina, DL | 1 |
| Rommens, J | 1 |
| Biffo, S | 1 |
| Frank, H | 1 |
| Gröger, N | 1 |
| Diener, M | 1 |
| Becker, C | 1 |
| Braun, T | 1 |
| Boettger, T | 1 |
| Backshall, A | 1 |
| Alferez, D | 1 |
| Teichert, F | 1 |
| Wilson, ID | 1 |
| Wilkinson, RW | 1 |
| Goodlad, RA | 1 |
| Keun, HC | 2 |
| de Groof, AJ | 1 |
| te Lindert, MM | 1 |
| van Dommelen, MM | 1 |
| Wu, M | 1 |
| Willemse, M | 1 |
| Smift, AL | 1 |
| Winer, M | 1 |
| Oerlemans, F | 1 |
| Pluk, H | 1 |
| Fransen, JA | 1 |
| Wieringa, B | 1 |
| Zhang, J | 2 |
| Lam, EK | 1 |
| Shin, VY | 1 |
| Cheng, AS | 1 |
| Yu, J | 1 |
| Chan, FK | 1 |
| Sung, JJ | 1 |
| Jin, HC | 1 |
| Cho, HS | 1 |
| Dong, Z | 1 |
| Pauletti, GM | 1 |
| Xu, H | 1 |
| Gu, H | 1 |
| Ewing, RC | 1 |
| Huth, C | 1 |
| Wang, F | 1 |
| Shi, D | 1 |
| Le Floch, R | 1 |
| Chiche, J | 1 |
| Marchiq, I | 1 |
| Naiken, T | 2 |
| Ilc, K | 1 |
| Ilk, K | 1 |
| Murray, CM | 1 |
| Critchlow, SE | 1 |
| Roux, D | 1 |
| Simon, MP | 1 |
| Pouysségur, J | 1 |
| Yuneva, MO | 1 |
| Fan, TW | 1 |
| Allen, TD | 1 |
| Higashi, RM | 1 |
| Ferraris, DV | 1 |
| Tsukamoto, T | 1 |
| Matés, JM | 1 |
| Alonso, FJ | 1 |
| Seo, Y | 1 |
| Bishop, JM | 1 |
| Luo, W | 1 |
| Semenza, GL | 1 |
| Guido, C | 2 |
| Whitaker-Menezes, D | 2 |
| Capparelli, C | 1 |
| Balliet, R | 1 |
| Lin, Z | 2 |
| Pestell, RG | 2 |
| Howell, A | 2 |
| Aquila, S | 2 |
| Andò, S | 1 |
| Zimmers, TA | 1 |
| Casimiro, MC | 1 |
| Ando', S | 1 |
| Martinez-Outschoorn, UE | 1 |
| Locasale, JW | 1 |
| Zhao, Y | 1 |
| Yang, W | 1 |
| Xia, Y | 1 |
| Cao, Y | 1 |
| Zheng, Y | 1 |
| Bu, W | 1 |
| You, MJ | 1 |
| Koh, MY | 1 |
| Cote, G | 1 |
| Aldape, K | 1 |
| Li, Y | 1 |
| Verma, IM | 1 |
| Chiao, PJ | 1 |
| Lu, Z | 1 |
| Jiménez, B | 1 |
| Mirnezami, R | 1 |
| Kinross, J | 1 |
| Cloarec, O | 1 |
| Holmes, E | 1 |
| Goldin, RD | 1 |
| Ziprin, P | 1 |
| Darzi, A | 1 |
| Nicholson, JK | 1 |
| Huber, AL | 1 |
| Lebeau, J | 1 |
| Guillaumot, P | 1 |
| Pétrilli, V | 1 |
| Malek, M | 1 |
| Chilloux, J | 1 |
| Fauvet, F | 1 |
| Payen, L | 1 |
| Kfoury, A | 1 |
| Renno, T | 1 |
| Chevet, E | 1 |
| Manié, SN | 1 |
| Salnikow, K | 1 |
| Davidson, T | 1 |
| Costa, M | 1 |
| Mueller-Klieser, WF | 1 |
| Chiaradonna, F | 1 |
| Sacco, E | 1 |
| Manzoni, R | 1 |
| Giorgio, M | 1 |
| Vanoni, M | 1 |
| Alberghina, L | 1 |
| Fantin, VR | 1 |
| St-Pierre, J | 1 |
| Leder, P | 1 |
| Funes, JM | 1 |
| Quintero, M | 1 |
| Henderson, S | 1 |
| Martinez, D | 1 |
| Qureshi, U | 1 |
| Westwood, C | 1 |
| Clements, MO | 1 |
| Bourboulia, D | 1 |
| Pedley, RB | 1 |
| Moncada, S | 1 |
| Boshoff, C | 1 |
| Huang, KH | 1 |
| Liu, JH | 1 |
| Zhu, ZH | 1 |
| Li, XX | 1 |
| Lu, XP | 1 |
| Zhou, SY | 1 |
| Kawauchi, K | 1 |
| Araki, K | 1 |
| Tobiume, K | 1 |
| Tanaka, N | 1 |
| Peterkofsky, B | 1 |
| Kalwinsky, D | 1 |
| Chauhan, U | 1 |
| Prather, W | 1 |
| Assad, R | 1 |
| Sens, DA | 1 |
| Hochstadt, B | 1 |
| Amos, H | 1 |
| Mothersill, C | 1 |
| Seymour, CB | 1 |
| Moriarty, M | 1 |
| Kaplan, AE | 1 |
| Yamaguchi, MK | 1 |
| Tralka, TS | 1 |
| Hanna, CH | 1 |
| Anghileri, LJ | 1 |
| Maincent, P | 1 |
| Thouvenot, P | 1 |
| Cordova-Martinez, A | 1 |
| Nyberg, SL | 1 |
| Remmel, RP | 1 |
| Mann, HJ | 1 |
| Peshwa, MV | 1 |
| Hu, WS | 1 |
| Cerra, FB | 1 |
| Tedeschi, G | 1 |
| Lundbom, N | 1 |
| Raman, R | 1 |
| Bonavita, S | 1 |
| Duyn, JH | 1 |
| Alger, JR | 1 |
| Di Chiro, G | 1 |
| Shino, A | 1 |
| Nakasu, S | 1 |
| Matsuda, M | 1 |
| Handa, J | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Kunz-Schughart, LA | 1 |
| Doetsch, J | 1 |
| Groebe, K | 1 |
| Wu, H | 1 |
| Scher, BM | 1 |
| Chu, CL | 1 |
| Leonard, M | 1 |
| Olmedo, R | 1 |
| Scher, GS | 1 |
| Stecker, S | 1 |
| Scher, W | 1 |
| Waxman, S | 1 |
| Andersen, JK | 1 |
| Zhang, MB | 1 |
| Zhong, XH | 1 |
| Rozenberg, YY | 1 |
| Howard, BD | 1 |
| Jullien, P | 1 |
| Berg, TM | 1 |
| Lawrence, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 18F-FDG Metabolism Imaging Monitoring Non-small Cell Lung Cancer Curative Effect of Chemotherapy Multicenter Clinical Study[NCT02938546] | Phase 3 | 200 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| What Are the Factors Affecting Neoadjuvant Chemotherapy Efficacy in Breast Cancer? A Non-invasive in Vivo Study Using Specialist Magnetic Resonance (MR) Methods[NCT03501394] | 25 participants (Anticipated) | Interventional | 2018-05-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for lactic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Lactate-related metabolic reprogramming and immune regulation in colorectal cancer.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glycolysis; Humans; Lactic Ac | 2022 |
Lactate-induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Lactic Acid; | 2023 |
Revisiting lactate dynamics in cancer-a metabolic expertise or an alternative attempt to survive?
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Energy Metabolism; Glycolysis; Humans; Lact | 2020 |
Cancer Metabolism Drives a Stromal Regenerative Response.
Topics: Amino Acids; Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Glucose; Hu | 2019 |
Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.
Topics: Animals; Autophagy; Breast Neoplasms; Cachexia; Carcinoma; Caveolin 1; Cell Line, Tumor; Cell Transf | 2014 |
Targeting cancer with nano-bullets: curcumin, EGCG, resveratrol and quercetin on flying carpets.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Catechin; Cell Pro | 2014 |
Sirtuins and the Metabolic Hurdles in Cancer.
Topics: Biosynthetic Pathways; Cell Transformation, Neoplastic; Energy Metabolism; Gluconeogenesis; Humans; | 2015 |
Emerging roles of PKM2 in cell metabolism and cancer progression.
Topics: Animals; Carrier Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; | 2012 |
Lactate: mirror and motor of tumor malignancy.
Topics: Cell Hypoxia; Cell Transformation, Neoplastic; Female; Humans; Hyaluronic Acid; Hypoxia-Inducible Fa | 2004 |
65 other studies available for lactic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.
Topics: Animals; Carbon; Cell Proliferation; Cell Transformation, Neoplastic; Humans; Hydrogen-Ion Concentra | 2022 |
Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Trans | 2022 |
Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Lactic Acid; Liver Neoplasms; M | 2022 |
Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colorecta | 2023 |
A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Glucosephosphate Dehydrogenase; Glutathione S-Trans | 2023 |
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts.
Topics: 5-Methylcytosine; Animals; Cancer-Associated Fibroblasts; Carcinoma, Pancreatic Ductal; Cell Line, T | 2019 |
3-Bromopyruvate inhibits the malignant phenotype of malignantly transformed macrophages and dendritic cells induced by glioma stem cells in the glioma microenvironment via miR-449a/MCT1.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Dendritic Cells; Glioma; Lactic Acid; Macrophages; | 2020 |
Identification of a new
Topics: Alternative Splicing; Animals; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferat | 2019 |
A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Drosophila melanogas | 2019 |
Near-infra-red fluorescent chitosan oligosaccharide lactate for targeted cancer imaging and photothermal therapy.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Chitosan; Fluorescent Dyes; Humans; Infr | 2020 |
SLC1A3 promotes gastric cancer progression via the PI3K/AKT signalling pathway.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Survival; Cell Transf | 2020 |
Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Citric Acid Cycle; Diet, High-F | 2021 |
Untargeted metabolomics and lipidomics analysis identified the role of FOXA1 in remodeling the metabolic pattern of BaP-transformed 16HBE cells.
Topics: Adenosine Triphosphate; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cit | 2021 |
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.
Topics: Animals; Cell Communication; Cell Line, Transformed; Cell Transformation, Neoplastic; Coculture Tech | 2017 |
Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.
Topics: Apoptosis; Biopsy; Cell Line, Tumor; Cell Transformation, Neoplastic; Coculture Techniques; Colon; C | 2018 |
MiR-323a-3p suppressed the glycolysis of osteosarcoma via targeting LDHA.
Topics: Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression; Gene Targeting; Glyco | 2018 |
Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies.
Topics: Animals; Antineoplastic Agents; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Transformation | 2018 |
Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.
Topics: Cell Communication; Cell Movement; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transitio | 2018 |
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
Topics: Basigin; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Membrane; Cell Proliferation; | 2018 |
Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome.
Topics: Amino Acid Transport System ASC; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neopla | 2019 |
Altered glucose metabolism in Harvey-ras transformed MCF10A cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Transformation, Neoplastic; Citric Acid Cycl | 2015 |
MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Cell Hypoxia; Cell Proliferation; Cel | 2014 |
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cluster | 2014 |
Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.
Topics: Adult; Aged; Animals; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Transformation, N | 2014 |
Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformati | 2014 |
Ovarian tumor-initiating cells display a flexible metabolism.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Disease | 2014 |
Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.
Topics: Animals; Antigen Presentation; Breast Neoplasms; Cancer Vaccines; Cell Transformation, Neoplastic; D | 2015 |
Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.
Topics: Adenosine Triphosphate; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2015 |
TNFR1 Regulates Ovarian Cancer Cell Tumorigenicity Through PIK3CB-p110Beta.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Class I Phosphatidylinositol 3-Kinases; | 2015 |
A novel perfused Bloch-McConnell simulator for analyzing the accuracy of dynamic hyperpolarized MRS.
Topics: Animals; Cell Transformation, Neoplastic; Lactic Acid; Magnetic Resonance Spectroscopy; Mice; Models | 2016 |
Transformation by different oncogenes relies on specific metabolic adaptations.
Topics: Adaptation, Physiological; Animals; Breast Neoplasms; Cell Respiration; Cell Transformation, Neoplas | 2016 |
SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Transformation, Neoplastic; DNA Damage; Fibroblasts | 2017 |
Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice.
Topics: Animals; Butyrates; Carcinogens; Cation Transport Proteins; Cell Transformation, Neoplastic; Colon; | 2008 |
Detection of metabolic alterations in non-tumor gastrointestinal tissue of the Apc(Min/+) mouse by (1)H MAS NMR spectroscopy.
Topics: Adenomatous Polyposis Coli Protein; Animals; Cell Transformation, Neoplastic; Colon; Dimethylamines; | 2009 |
Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype.
Topics: Adenovirus E1A Proteins; Animals; Cell Line, Transformed; Cell Proliferation; Cell Transformation, N | 2009 |
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.
Topics: Aged; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Methylation; Down-Regulation; | 2010 |
Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Carriers; Fluorescent Dyes; Humans; | 2010 |
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; DNA Primers; Flow Cy | 2011 |
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Transformation, Neoplastic; Citric Acid Cycle; DN | 2012 |
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
Topics: Animals; Autocrine Communication; Autophagy; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Tr | 2012 |
Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.
Topics: Adenosine Triphosphate; Autophagy; Cell Line, Tumor; Cell Transformation, Neoplastic; Energy Metabol | 2012 |
The consequences of enhanced cell-autonomous glucose metabolism.
Topics: Animals; Biological Transport; Cell Transformation, Neoplastic; Glucose; Glycolysis; Humans; Lactic | 2012 |
Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Respiration; Cell Transformation, Neoplastic; Do | 2013 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Amino Acids; Biomarkers, Tumor; Cell Transformation, | 2013 |
p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose.
Topics: Acetylgalactosamine; Animals; Apoptosis; Cell Hypoxia; Cell Line; Cell Proliferation; Cell Transform | 2013 |
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis.
Topics: Animals; Cell Cycle Proteins; Cell Hypoxia; Cell Transformation, Neoplastic; Disease Progression; DN | 2002 |
[Decreasing the risk of developing colorectal carcinoma. Lactic acid forming bacteria].
Topics: Animals; Bifidobacterium; Cell Transformation, Neoplastic; Clinical Trials as Topic; Colorectal Neop | 2003 |
Ras-dependent carbon metabolism and transformation in mouse fibroblasts.
Topics: Animals; Apoptosis; Cell Cycle; Cell Death; Cell Transformation, Neoplastic; Cells, Cultured; Enzyme | 2006 |
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2006 |
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.
Topics: Adenosine Triphosphate; Adult; Blotting, Western; Cell Transformation, Neoplastic; Energy Metabolism | 2007 |
[Biodistribution of (99m)Tc-labeled anti-VEGF mAb 5-FU loaded polylactic acid nanoparticles in human gastric carcinoma xenografts].
Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Fluorour | 2007 |
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Fibroblasts; Genes, ras; Glucose; Glucose | 2008 |
Regulation of prolyl hydroxylase activity in L-929 cells by mechanisms unrelated to glycolytic metabolism.
Topics: Animals; Ascorbic Acid; Cell Line; Cell Transformation, Neoplastic; Enzyme Activation; Glycolysis; L | 1984 |
Effects of pyruvate on the growth of normal and transformed hamster embryo fibroblasts.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cric | 1982 |
Lactate-mediated changes in growth morphology and transformation frequency of irradiated C3H 10T1/2 cells.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; Embr | 1983 |
Ultrastructural differences between control and nitrosomethylurea-transformed cells of rat hepatocyte origin.
Topics: Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Cytoplasmic Granules; | 1982 |
Liver calcium homeostasis modification by iron: a probable factor in its carcinogenesis.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Radioisotopes; Cell Transformation, Neoplastic; Fe | 1994 |
Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver.
Topics: Albumins; Animals; Artificial Organs; Biotransformation; Cell Line, Transformed; Cell Transformation | 1994 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Noninvasive evaluation of the malignant potential of intracranial meningiomas performed using proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Nuclear; Biomarkers, Tumor; Brain; Cell Division; Cell Tra | 1999 |
Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture.
Topics: Adenosine Triphosphate; Animals; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplas | 2000 |
Reduction in lactate accumulation correlates with differentiation-induced terminal cell division of leukemia cells.
Topics: Acetamides; Animals; Carbon Dioxide; Cell Differentiation; Cell Division; Cell Transformation, Neopl | 1991 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-resistant, flat-cell PC12 variants having a partial loss of transformed phenotype.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adrenal Gland Neoplasms; Animals; Cell Transformation, | 1990 |
Acidic cellular environments: activation of latent TGF-beta and sensitization of cellular responses to TGF-beta and EGF.
Topics: Agar; Animals; Blood; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Epid | 1989 |