lactic acid has been researched along with Cardiomyopathy, Dilated in 21 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This association is suggestive of the MIDD syndrome and the demonstration of metabolic abnormalities (raised serum lactic acid, abnormal lactate/pyruvate ratio) was compatible with a mitochondrial disease." | 3.74 | [Dilated cardiomyopathy, diabetes and deafness related to a mutation of mitochondrial DNA]. ( Charbonnier, B; Ferreira-Maldent, N; Guilmot, JL; Maillot, F; Quilliet, L, 2007) |
| "Treatment with clonidine markedly suppressed norepinephrine levels during exercise (matched peak exercise workload: control, 2137 +/- 187 versus clonidine, 1430 +/- 161 pg/mL), increased leg blood flow (control, 1." | 2.68 | Effect of sympathoinhibition on exercise performance in patients with heart failure. ( Chomsky, DB; Lang, CC; Rayos, GH; Wilson, JR; Wood, AJ, 1997) |
| "Cardiac functional deterioration in dilated cardiomyopathy (DCM) is known to be reversed by intramyocardial up-regulation of multiple cardioprotective factors, whereas a prostacyclin analog, ONO1301, has been shown to paracrinally activate interstitial cells to release a variety of protective factors." | 1.39 | A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure. ( Daimon, T; Fukushima, S; Kawaguchi, N; Matsuura, N; Miyagawa, S; Nakatani, S; Okita, Y; Saito, A; Sakai, Y; Sawa, Y; Shiozaki, M; Shirasaka, T, 2013) |
| "Cardiac fibrosis was significantly reduced by ONO-1301-PLGA (p<0." | 1.35 | Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters. ( Akaike, M; Hirata, Y; Igarashi, T; Sakai, Y; Sata, M; Soeki, T, 2009) |
| "Primary dilated cardiomyopathy is a disease of unknown etiology, and it leads to severe heart failure." | 1.32 | Usefulness of 1H MR spectroscopy in the evaluation of myocardial metabolism in patients with dilated idiopathic cardiomyopathy: pilot study. ( Bilinska, ZT; Michalak, E; Michalak, MJ; Ruzyllo, W; Walecki, J, 2003) |
| "Nine consecutive patients having severe idiopathic dilated cardiomyopathy were studied for their response in ventricular function, coronary sinus blood flow and myocardial oxygen consumption, lactate extraction and efficiency following incremental doses of dobutamine, followed by the combination of dobutamine and the phosphodiesterase inhibitor amrinone." | 1.28 | Myocardial energetics and efficiency in patients with idiopathic cardiomyopathy: response to dobutamine and amrinone. ( Janicki, JS; McElroy, PA; Reddy, HK; Sundram, P; Weber, KT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Varela, ML | 1 |
| Mota, T | 1 |
| Martins Fernandes, R | 1 |
| Soto, F | 1 |
| Shirasaka, T | 1 |
| Miyagawa, S | 1 |
| Fukushima, S | 1 |
| Saito, A | 1 |
| Shiozaki, M | 1 |
| Kawaguchi, N | 1 |
| Matsuura, N | 1 |
| Nakatani, S | 1 |
| Sakai, Y | 2 |
| Daimon, T | 1 |
| Okita, Y | 1 |
| Sawa, Y | 1 |
| Tricò, D | 1 |
| Baldi, S | 1 |
| Frascerra, S | 1 |
| Venturi, E | 1 |
| Marraccini, P | 2 |
| Neglia, D | 2 |
| Natali, A | 2 |
| Hirata, Y | 1 |
| Soeki, T | 1 |
| Akaike, M | 1 |
| Igarashi, T | 1 |
| Sata, M | 1 |
| Obrzut, S | 1 |
| Tiongson, J | 1 |
| Jamshidi, N | 1 |
| Phan, HM | 1 |
| Hoh, C | 1 |
| Birgersdotter-Green, U | 1 |
| Nohé, B | 1 |
| Ploppa, A | 1 |
| Schmidt, V | 1 |
| Unertl, K | 1 |
| Prada, CE | 1 |
| Al Jasmi, F | 1 |
| Kirk, EP | 1 |
| Hopp, M | 1 |
| Jones, O | 1 |
| Leslie, ND | 1 |
| Burrow, TA | 1 |
| Kemppainen, J | 1 |
| Stolen, K | 1 |
| Kalliokoski, KK | 1 |
| Salo, T | 1 |
| Karanko, H | 1 |
| Viljanen, T | 1 |
| Airaksinen, J | 1 |
| Nuutila, P | 1 |
| Knuuti, J | 1 |
| Walecki, J | 1 |
| Michalak, MJ | 1 |
| Michalak, E | 1 |
| Bilinska, ZT | 1 |
| Ruzyllo, W | 1 |
| Nikolaidis, LA | 1 |
| Sturzu, A | 1 |
| Stolarski, C | 1 |
| Elahi, D | 1 |
| Shen, YT | 1 |
| Shannon, RP | 1 |
| Ferreira-Maldent, N | 1 |
| Maillot, F | 1 |
| Quilliet, L | 1 |
| Guilmot, JL | 1 |
| Charbonnier, B | 1 |
| Ingwall, JS | 1 |
| De Caterina, A | 1 |
| Ciardetti, M | 1 |
| Vecoli, C | 1 |
| Gastaldelli, A | 1 |
| Ciociaro, D | 1 |
| Pellegrini, P | 1 |
| Testa, R | 1 |
| Menichetti, L | 1 |
| L'Abbate, A | 1 |
| Stanley, WC | 1 |
| Recchia, FA | 1 |
| Magnusson, G | 1 |
| Kaijser, L | 1 |
| Sylvén, C | 1 |
| Karlberg, KE | 1 |
| Isberg, B | 1 |
| Saltin, B | 1 |
| Lang, CC | 1 |
| Rayos, GH | 1 |
| Chomsky, DB | 1 |
| Wood, AJ | 1 |
| Wilson, JR | 1 |
| Grünewald, S | 1 |
| Bakkeren, J | 1 |
| Wanders, RA | 1 |
| Wendel, U | 1 |
| Lehmann, M | 1 |
| Hasenfuss, G | 1 |
| Samek, L | 1 |
| Gastmann, M | 1 |
| Sundram, P | 1 |
| Reddy, HK | 1 |
| McElroy, PA | 1 |
| Janicki, JS | 1 |
| Weber, KT | 1 |
| Mäki, T | 1 |
| Leinonen, H | 1 |
| Näveri, H | 1 |
| Sovijärvi, A | 1 |
| Kontula, K | 1 |
| Härkönen, M | 1 |
| Klein, HH | 1 |
| Spaar, U | 1 |
| Schlepple, H | 1 |
| Wiegand, V | 1 |
| Kreuzer, H | 1 |
| Schwarz, KR | 1 |
| Hofmann, M | 1 |
| Mäurer, W | 1 |
| Kadel, C | 1 |
| von Olshausen, K | 1 |
| Rauch, B | 1 |
| Kübler, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Abnormal Glucose Tolerance is Associated With a Reduced Myocardial Metabolic Flexibility in Patients With Dilated Cardiomyopathy[NCT02440217] | 15 participants (Anticipated) | Observational | 2015-05-31 | Enrolling by invitation | |||
| Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy[NCT04222101] | 9 participants (Actual) | Interventional | 2019-10-07 | Terminated (stopped due to COVID-19 pandemic) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for lactic acid and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
[Volume replacement in intensive care medicine].
Topics: Blood Pressure; Blood Volume; Cardiomyopathy, Dilated; Cholecystectomy; Colloids; Critical Care; Goa | 2011 |
3 trials available for lactic acid and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy.
Topics: Aged; Biomarkers; Blood Flow Velocity; Blood Glucose; Cardiac Pacing, Artificial; Cardiomyopathy, Di | 2016 |
Effect of sympathoinhibition on exercise performance in patients with heart failure.
Topics: Cardiomyopathy, Dilated; Chronic Disease; Clonidine; Coronary Disease; Exercise; Exercise Test; Hemo | 1997 |
[Chronic therapy of congestive cardiomyopathy: effects of prenalterol and digoxin].
Topics: Adult; Cardiac Output; Cardiac Volume; Cardiomyopathy, Dilated; Cardiotonic Agents; Clinical Trials | 1985 |
17 other studies available for lactic acid and Cardiomyopathy, Dilated
| Article | Year |
|---|---|
Peeking at the right heart at the right moment: a giant thrombus in transit.
Topics: Acute-On-Chronic Liver Failure; Anticoagulants; Cardiomyopathy, Dilated; Dyspnea; Echocardiography; | 2020 |
A slow-releasing form of prostacyclin agonist (ONO1301SR) enhances endogenous secretion of multiple cardiotherapeutic cytokines and improves cardiac function in a rapid-pacing-induced model of canine heart failure.
Topics: Animals; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Cardiovascula | 2013 |
Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.
Topics: Animals; Cardiomyopathy, Dilated; Cricetinae; Delayed-Action Preparations; Disease Models, Animal; D | 2009 |
Assessment of metabolic phenotypes in patients with non-ischemic dilated cardiomyopathy undergoing cardiac resynchronization therapy.
Topics: Adenosine Triphosphate; Adult; Aged; Amino Acids; Biomarkers; Blood Glucose; Cardiac Resynchronizati | 2010 |
Cardiac disease in methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Aortic Valve Stenosis; Cardiomegaly; Cardiomyopathy, Dilated; | 2011 |
Exercise training improves insulin stimulated skeletal muscle glucose uptake independent of changes in perfusion in patients with dilated cardiomyopathy.
Topics: Adipose Tissue; Adult; Biomarkers; Blood Glucose; Blood Pressure; Cardiomyopathy, Dilated; Diastole; | 2003 |
Usefulness of 1H MR spectroscopy in the evaluation of myocardial metabolism in patients with dilated idiopathic cardiomyopathy: pilot study.
Topics: Adult; Cardiomyopathy, Dilated; Creatine; Echocardiography; Female; Humans; Lactic Acid; Lipids; Mag | 2003 |
The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cardiac Pacing, Artificial; Cardiomyopathy, Dila | 2004 |
[Dilated cardiomyopathy, diabetes and deafness related to a mutation of mitochondrial DNA].
Topics: Cardiomyopathy, Dilated; Deafness; Diabetes Mellitus; DNA, Mitochondrial; Female; Humans; Lactic Aci | 2007 |
On substrate selection for ATP synthesis in the failing human myocardium.
Topics: Adenosine Triphosphate; Animals; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Coronary Circu | 2007 |
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
Topics: Aged; Carbon Isotopes; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; | 2007 |
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
Topics: Aged; Carbon Isotopes; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; | 2007 |
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
Topics: Aged; Carbon Isotopes; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; | 2007 |
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
Topics: Aged; Carbon Isotopes; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; | 2007 |
Peak skeletal muscle perfusion is maintained in patients with chronic heart failure when only a small muscle mass is exercised.
Topics: Cardiac Output; Cardiomyopathy, Dilated; Chronic Disease; Exercise; Female; Humans; Lactic Acid; Leg | 1997 |
Neonatal lethal mitochondrial trifunctional protein deficiency mimicking a respiratory chain defect.
Topics: Ammonia; Cardiomyopathy, Dilated; Electron Transport; Fatal Outcome; Female; Humans; Hypoglycemia; I | 1997 |
Catecholamine metabolism in heart failure patients and healthy control subjects.
Topics: Adult; Aged; Blood Pressure; Cardiomyopathy, Dilated; Catecholamines; Exercise; Half-Life; Heart Fai | 1990 |
Myocardial energetics and efficiency in patients with idiopathic cardiomyopathy: response to dobutamine and amrinone.
Topics: Amrinone; Cardiomyopathy, Dilated; Dobutamine; Drug Therapy, Combination; Hemodynamics; Humans; Lact | 1990 |
Response of the beta-adrenergic system to maximal dynamic exercise in congestive heart failure secondary to idiopathic dilated cardiomyopathy.
Topics: Adult; Cardiomyopathy, Dilated; Cyclic AMP; Epinephrine; Exercise; Exercise Test; Female; Heart Fail | 1989 |
Comparative analysis of myocardial enzyme activities of the energy-supplying metabolism in patients with dilative cardiomyopathies and valve diseases.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Cardiomyopathy, Dilated; Citric Acid Cycle; Creatine Kinase; Energ | 1986 |