lactic acid has been researched along with Cardiomegaly in 42 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Excerpt | Relevance | Reference |
---|---|---|
"Pimobendan has gained enormous importance in the treatment of mitral valve disease in dogs." | 6.90 | Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly. ( Bach, JP; Iwanuk, N; Nolte, I; Pilgram, A; Raue, J; Rohn, K; Rumstedt, K; Sehn, M; Wall, L, 2019) |
"Pimobendan has gained enormous importance in the treatment of mitral valve disease in dogs." | 2.90 | Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly. ( Bach, JP; Iwanuk, N; Nolte, I; Pilgram, A; Raue, J; Rohn, K; Rumstedt, K; Sehn, M; Wall, L, 2019) |
"As evidence on the predominant type of cardiac hypertrophy due to endurance running training is inconsistent, the aim of this study was to investigate the effect of increased training volume on echocardiographic variables of distance runners." | 2.72 | Concentric myocardial hypertrophy after one year of increased training volume in experienced distance runners. ( Raugaliene, R; Stasiulis, A; Venckunas, T, 2006) |
"Mice were subjected to cardiac hypertrophy secondary to pressure-overload as a result of an abdominal aortic constriction (AAC)." | 1.39 | Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. ( Jaswal, JS; Lopaschuk, GD; Sankaralingam, S; Ussher, JR; Wagg, C; Zaugg, M; Zhang, L, 2013) |
"Exercise-induced cardiac hypertrophy has been recently identified to be regulated in a sex-specific manner." | 1.37 | Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability. ( Benz, V; Böhm, C; Dragun, D; Foryst-Ludwig, A; Gürgen, D; Kintscher, U; Kreissl, MC; Mai, K; Regitz-Zagrosek, V; Schubert, C; Sprang, C; Spranger, J; Stawowy, P; Thalke, B; Unger, T, 2011) |
"Heart hypertrophy is a common finding of acromegaly, a syndrome due to GH excess." | 1.34 | Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH. ( Bartalena, L; Bogazzi, F; D'Alessio, A; Fanelli, G; Gasperi, M; Manariti, A; Martino, E; Raggi, F; Russo, D; Ultimieri, F; Viacava, P, 2007) |
"Hypertension-induced pathological cardiac hypertrophy (hypertensive heart) and exercise training-induced physiological cardiac hypertrophy (athletic heart) have differences in cardiac properties." | 1.32 | Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism. ( Fujii, N; Iemitsu, M; Kakinuma, Y; Maeda, S; Matsuda, M; Miyauchi, T; Miyazaki, H; Sakai, S; Yamaguchi, I, 2003) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 9 (21.43) | 18.7374 |
1990's | 15 (35.71) | 18.2507 |
2000's | 11 (26.19) | 29.6817 |
2010's | 5 (11.90) | 24.3611 |
2020's | 2 (4.76) | 2.80 |
Authors | Studies |
---|---|
Jian, L | 1 |
Gao, X | 1 |
Wang, C | 1 |
Sun, X | 1 |
Xu, Y | 1 |
Han, R | 1 |
Wang, Y | 1 |
Xu, S | 1 |
Ding, L | 1 |
Zhou, J | 1 |
Gu, Y | 1 |
Zhao, Y | 1 |
Yang, Y | 1 |
Yuan, Y | 1 |
Ye, J | 1 |
Zhang, L | 2 |
Iwanuk, N | 1 |
Wall, L | 1 |
Nolte, I | 1 |
Raue, J | 1 |
Rumstedt, K | 1 |
Pilgram, A | 1 |
Sehn, M | 1 |
Rohn, K | 1 |
Bach, JP | 1 |
Cluntun, AA | 1 |
Badolia, R | 1 |
Lettlova, S | 1 |
Parnell, KM | 1 |
Shankar, TS | 1 |
Diakos, NA | 1 |
Olson, KA | 1 |
Taleb, I | 1 |
Tatum, SM | 1 |
Berg, JA | 1 |
Cunningham, CN | 1 |
Van Ry, T | 1 |
Bott, AJ | 1 |
Krokidi, AT | 1 |
Fogarty, S | 1 |
Skedros, S | 1 |
Swiatek, WI | 1 |
Yu, X | 1 |
Luo, B | 1 |
Merx, S | 1 |
Navankasattusas, S | 1 |
Cox, JE | 1 |
Ducker, GS | 1 |
Holland, WL | 1 |
McKellar, SH | 1 |
Rutter, J | 1 |
Drakos, SG | 1 |
Jaswal, JS | 1 |
Ussher, JR | 1 |
Sankaralingam, S | 1 |
Wagg, C | 1 |
Zaugg, M | 1 |
Lopaschuk, GD | 3 |
Avad, AS | 1 |
Lutsenko, RV | 1 |
Malyk, SV | 1 |
Foryst-Ludwig, A | 1 |
Kreissl, MC | 1 |
Sprang, C | 1 |
Thalke, B | 1 |
Böhm, C | 1 |
Benz, V | 1 |
Gürgen, D | 1 |
Dragun, D | 1 |
Schubert, C | 1 |
Mai, K | 1 |
Stawowy, P | 1 |
Spranger, J | 1 |
Regitz-Zagrosek, V | 1 |
Unger, T | 1 |
Kintscher, U | 1 |
Prada, CE | 1 |
Al Jasmi, F | 1 |
Kirk, EP | 1 |
Hopp, M | 1 |
Jones, O | 1 |
Leslie, ND | 1 |
Burrow, TA | 1 |
Iemitsu, M | 1 |
Miyauchi, T | 1 |
Maeda, S | 1 |
Sakai, S | 1 |
Fujii, N | 1 |
Miyazaki, H | 1 |
Kakinuma, Y | 1 |
Matsuda, M | 1 |
Yamaguchi, I | 1 |
King, N | 2 |
Lin, H | 2 |
McGivan, JD | 2 |
Suleiman, MS | 2 |
Godfried, MH | 1 |
Boer, K | 1 |
Beuger, S | 1 |
Scherpbier, HJ | 1 |
Kuijpers, TW | 1 |
Saeedi, R | 1 |
Grist, M | 1 |
Wambolt, RB | 1 |
Bescond-Jacquet, A | 1 |
Lucien, A | 1 |
Allard, MF | 4 |
Venckunas, T | 1 |
Stasiulis, A | 1 |
Raugaliene, R | 1 |
Bogazzi, F | 1 |
Raggi, F | 1 |
Ultimieri, F | 1 |
Russo, D | 1 |
Manariti, A | 1 |
D'Alessio, A | 1 |
Viacava, P | 1 |
Fanelli, G | 1 |
Gasperi, M | 1 |
Bartalena, L | 1 |
Martino, E | 1 |
Itoh, K | 1 |
Minakawa, M | 1 |
Ono, Y | 1 |
Tsushima, T | 1 |
Fukui, K | 1 |
Fukuda, I | 1 |
Sugden, PH | 1 |
Smith, DM | 1 |
Salerno, TA | 1 |
Chiong, MA | 1 |
Bache, RJ | 1 |
Arentzen, CE | 1 |
Simon, AB | 1 |
Vrobel, TR | 1 |
McAinsh, AM | 1 |
Turner, MA | 1 |
O'Hare, D | 1 |
Nithythyananthan, R | 1 |
Johnston, DG | 1 |
O'Gorman, DJ | 1 |
Sheridan, DJ | 1 |
Takeuchi, K | 1 |
Buenaventura, P | 1 |
Cao-Danh, H | 1 |
Glynn, P | 1 |
Simplaceanu, E | 1 |
McGowan, FX | 1 |
del Nido, PJ | 2 |
Golden, AL | 1 |
Bright, JM | 1 |
Pohost, GM | 1 |
Pike, MM | 1 |
Mäntymaa, P | 1 |
Arokoski, J | 1 |
Pörsti, I | 1 |
Perhonen, M | 1 |
Arvola, P | 1 |
Helminen, HJ | 1 |
Takala, TE | 2 |
Leppäluoto, J | 2 |
Ruskoaho, H | 2 |
Schönekess, BO | 2 |
Henning, SL | 1 |
English, DR | 1 |
Mochizuki, T | 1 |
Eberli, FR | 1 |
Ngoy, S | 1 |
Apstein, CS | 3 |
Lorell, BH | 2 |
Rubio-Gozalbo, ME | 1 |
Smeitink, JA | 1 |
Ruitenbeek, W | 1 |
Ter Laak, H | 1 |
Mullaart, RA | 1 |
Schuelke, M | 1 |
Mariman, EC | 1 |
Sengers, RC | 1 |
Gabreëls, FJ | 1 |
Binas, B | 1 |
Danneberg, H | 1 |
McWhir, J | 1 |
Mullins, L | 1 |
Clark, AJ | 1 |
Rupert, BE | 1 |
Segar, JL | 1 |
Schutte, BC | 1 |
Scholz, TD | 1 |
Giordano, G | 1 |
Corradi, D | 1 |
D'Adda, T | 1 |
Melissari, M | 1 |
Devi, SA | 1 |
Jolitha, AB | 1 |
Prathima, S | 1 |
Goodman, JM | 1 |
McLaughlin, PR | 1 |
Plyley, MJ | 1 |
Holloway, RM | 1 |
Fell, D | 1 |
Logan, AG | 1 |
Liu, PP | 1 |
Munfakh, NA | 1 |
Steinberg, JB | 1 |
Titus, JS | 1 |
Denenberg, AG | 1 |
O'Keefe, DD | 1 |
Daggett, WM | 1 |
Geffin, GA | 1 |
Tanaka, H | 1 |
Obata, H | 1 |
Haneda, T | 1 |
Cunningham, MJ | 1 |
Weinberg, EO | 2 |
Vogel, WM | 1 |
Gaasch, WH | 1 |
Zile, MR | 1 |
Hoshino, PK | 1 |
Rhodes, DR | 1 |
Anderson, PG | 1 |
Thomas, GD | 1 |
Bishop, SP | 1 |
Digerness, SB | 1 |
Scheld, HH | 1 |
Görlach, G | 1 |
Mulch, J | 1 |
Podzuweit, T | 1 |
Höge, R | 1 |
Hehrlein, FW | 1 |
Schaper, W | 1 |
Kinnunen, P | 1 |
Taskinen, T | 1 |
Vuolteenaho, O | 1 |
Ji, LL | 1 |
Stratman, FW | 1 |
Lardy, HA | 1 |
Whitmer, JT | 1 |
Benson, LN | 1 |
Mickle, DA | 1 |
Kielmanowicz, S | 1 |
Coles, JG | 1 |
Wilson, GJ | 1 |
Hickson, RC | 1 |
Foster, C | 1 |
Pollock, ML | 1 |
Galassi, TM | 1 |
Rich, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effects of Nebivolol on Microvascular Perfusion in the Skeletal Muscles During Exercise in Hypertensive Patients[NCT01501929] | Phase 4 | 32 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Endothelial cell (EC) was collected after a 20-guage angiocatheter was inserted into the contralateral forearm vein under sterile conditions. Three J-shaped vascular guidewires (St. Jude, St. Paul, MN) were advanced sequentially into the vein up to 10 cm. Endothelial cells were collected by gentle abrasion and placed into a dissociation buffer (0.5% bovine serum albumin, 2mM EDTA, and 100 ug/ml heparin in PBS). Endothelial cells were recovered from the tips of guide wires by repeated washing into collection tubes and subsequent centrifugation. EC were incubated with monoclonal antibodies against the polyclonal antibodies against NADPH oxidase p47 subunit. The intensity of staining was measured using fluorescence microscopy. (NCT01501929)
Timeframe: 12 weeks
Intervention | Ratio human to HUVEC p47Phox expression (Mean) |
---|---|
Metoprolol | 0.47 |
Nebivolol | 0.44 |
Microvascular perfusion of skeletal muscle were measured during handgrip at 20 cycle per minute after 12 weeks of metoprolol, and after 12 weeks of nebivolol (NCT01501929)
Timeframe: 12 weeks
Intervention | video intensity units/ second (Median) |
---|---|
Metoprolol | 43.938 |
Nebivolol | 74.584 |
3 trials available for lactic acid and Cardiomegaly
Article | Year |
---|---|
Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly.
Topics: Animals; Cardiomegaly; Dog Diseases; Dogs; Echocardiography; Exercise Test; Female; Heart Murmurs; H | 2019 |
[FACTORIAL ANALYSIS IN PROGNOSTICATION OF INFECTIOUS COMPLICATIONS AFTER SIMULTANT OPERATIVE INTERVENTIONS FOR BILIARY CALCULOUS DISEASE].
Topics: Aged; Algorithms; Bacterial Infections; Blood Glucose; Cardiomegaly; Cholecystectomy, Laparoscopic; | 2016 |
Concentric myocardial hypertrophy after one year of increased training volume in experienced distance runners.
Topics: Adolescent; Adult; Cardiomegaly; Exercise Test; Humans; Hypertrophy, Left Ventricular; Lactic Acid; | 2006 |
39 other studies available for lactic acid and Cardiomegaly
Article | Year |
---|---|
Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
Topics: Animals; Cardiomegaly; Fatty Acids; Glucose; Insulin Resistance; Lactic Acid; Leptin; Mice; Perilipi | 2023 |
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.
Topics: Animals; Anion Transport Proteins; Cardiomegaly; Heart Failure; Heart-Assist Devices; Humans; Lactic | 2021 |
Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy.
Topics: Adenosine Triphosphate; Animals; Aorta, Abdominal; Arterial Pressure; Blood Glucose; Cardiomegaly; D | 2013 |
Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability.
Topics: Adipose Tissue; Animals; Blotting, Western; Calorimetry; Cardiomegaly; Echocardiography; Energy Meta | 2011 |
Cardiac disease in methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Aortic Valve Stenosis; Cardiomegaly; Cardiomyopathy, Dilated; | 2011 |
Cardiac hypertrophy by hypertension and exercise training exhibits different gene expression of enzymes in energy metabolism.
Topics: Animals; Cardiomegaly; Carnitine O-Palmitoyltransferase; CD36 Antigens; Coenzyme A Ligases; Fatty Ac | 2003 |
Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, | 2004 |
A neonate with macrosomia, cardiomyopathy and hepatomegaly born to an HIV-infected mother.
Topics: Adipose Tissue; Antiretroviral Therapy, Highly Active; Arginine; Asphyxia; Brain; Cardiomegaly; Card | 2005 |
Trimetazidine normalizes postischemic function of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Glucose; Glycolysis; Kinetics; | 2005 |
Expression and activity of the glutamate transporter EAAT2 in cardiac hypertrophy: implications for ischaemia reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomegaly; Cardiotonic Agents; Excitatory Amino | 2006 |
Cardiac expression of adenine nucleotide translocase-1 in transgenic mice overexpressing bovine GH.
Topics: Acromegaly; Adenine Nucleotide Translocator 1; Adenosine Triphosphate; Animals; Blotting, Western; C | 2007 |
Role of oxidative stress in hypertrophied myoblasts stimulated by isoproterenol.
Topics: Animals; Apoptosis; Cardiomegaly; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Gluco | 2008 |
Protein turnover in the in vitro perfused working rat heart.
Topics: Animals; Aorta; Atrial Function; Blood Pressure; Cardiac Output; Cardiomegaly; Coronary Circulation; | 1984 |
Ventricular fibrillation induced prior to cardioplegic arrest in hypertrophied pig hearts.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Cardiomegaly; Creatine Kinase; Glycogen; Heart | 1983 |
Abnormalities in myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy: metabolic evidence for myocardial ischemia.
Topics: Adenosine; Animals; Blood Pressure; Cardiac Pacing, Artificial; Cardiomegaly; Coronary Circulation; | 1984 |
Cardiac hypertrophy impairs recovery from ischaemia because there is a reduced reactive hyperaemic response.
Topics: Animals; Cardiomegaly; Coronary Circulation; Guinea Pigs; Hyperemia; Lactates; Lactic Acid; Male; My | 1995 |
Improved protection of the hypertrophied left ventricle by histidine-containing cardioplegia.
Topics: Animals; Cardiomegaly; Energy Metabolism; Heart; Heart Arrest, Induced; Histidine; Hydrogen-Ion Conc | 1995 |
Ischemic dysfunction and impaired recovery in hypertensive hypertrophied hearts is associated with exaggerated intracellular sodium accumulation.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Hydrogen-Ion Concentration; Hypertension; Lactates; L | 1994 |
Effect of endurance training on atrial natriuretic peptide gene expression in normal and hypertrophied hearts.
Topics: Animals; Atrial Natriuretic Factor; Blotting, Northern; Body Weight; Cardiomegaly; Dogs; Eating; Fem | 1994 |
Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.
Topics: Adenosine Triphosphate; Animals; Body Weight; Cardiomegaly; Energy Metabolism; Glucose; Glycolysis; | 1994 |
Effects of brief repetitive ischemia on contractility, relaxation, and coronary flow. Exaggerated postischemic diastolic dysfunction in pressure-overload hypertrophy.
Topics: Animals; Cardiomegaly; Coronary Circulation; Diastole; Glycolysis; Lactates; Lactic Acid; Male; Myoc | 1993 |
Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Aorta; Cardiomegaly; Constriction; Glucose; Glycolysis; Heart; Home | 1996 |
Spinal muscular atrophy-like picture, cardiomyopathy, and cytochrome c oxidase deficiency.
Topics: Blotting, Western; Cardiomegaly; Cells, Cultured; Cytochrome-c Oxidase Deficiency; Fibroblasts; Huma | 1999 |
Requirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Cardiomegaly; Carrier Proteins; Disease Models, Anima | 1999 |
Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles.
Topics: Adenosine Triphosphate; Animals; Aorta; Aspartic Acid; Atrial Natriuretic Factor; Blotting, Northern | 2000 |
[An autopsy case of neonatal lactic acidosis].
Topics: Acidosis, Lactic; Atrophy; Autopsy; Body Fluids; Brain; Cardiomegaly; Epilepsy, Generalized; Fatal O | 2001 |
Temperature-induced changes in anaerobic capacity of interventricular septum in trained young and middle-aged rats.
Topics: Aging; Anaerobiosis; Animals; Cardiomegaly; Heart; Heart Septum; Heart Ventricles; Isoenzymes; L-Lac | 2002 |
Impaired cardiopulmonary response to exercise in moderate hypertension.
Topics: Adult; Cardiomegaly; Exercise; Exercise Test; Female; Hemodynamics; Humans; Hypertension; Lactates; | 1992 |
Protection of the hypertrophied myocardium by crystalloid cardioplegia.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Creatine Kinase; Crystalloid Solutions; Heart Ar | 1991 |
Effects of regression of left ventricular hypertrophy following atenolol or bunazosin therapy on ischemic cardiac function and myocardial metabolism in spontaneously hypertensive rats.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Atenolol; Blood Pre | 1991 |
Influence of glucose and insulin on the exaggerated diastolic and systolic dysfunction of hypertrophied rat hearts during hypoxia.
Topics: Animals; Cardiomegaly; Diastole; Glucose; Heart; Hypoxia; Insulin; Lactates; Lactic Acid; Male; Osmo | 1990 |
Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Dogs; Heart Arrest, Induced; He | 1990 |
Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts.
Topics: Adenosine Triphosphate; Animals; Aorta; Cardiomegaly; Constriction; Coronary Disease; Glycogen; Hear | 1990 |
Protection of the hypertrophied human heart by adjusting regional myocardial temperature to a safe level.
Topics: Adenosine Triphosphate; Aortic Valve; Bicarbonates; Calcium Chloride; Cardiomegaly; Female; Glucose; | 1985 |
Regulation of ventricular atrial natriuretic peptide release in hypertrophied rat myocardium. Effects of exercise.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Catecholamines; Heart Ventricles; Hypertension; La | 1989 |
Effects of beta 1- and beta 1 + beta 2-antagonists on training-induced myocardial hypertrophy and enzyme adaptation.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adaptation, Physiological; Adrenergic beta-Antagonists; Animals; B | 1987 |
Energy metabolism and mechanical function in perfused hearts of Syrian hamsters with dilated or hypertrophic cardiomyopathy.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiomegaly; Carnitine; Coenzyme A; Coronary Circu | 1986 |
Impaired left ventricular postischemic function and metabolism in chronic right ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Cardiac Volume; Cardiomegaly; Chronic Disease; Coronary Circulation | 1987 |
Reduced training intensities and loss of aerobic power, endurance, and cardiac growth.
Topics: Adaptation, Physiological; Adult; Body Weight; Cardiomegaly; Echocardiography; Female; Heart; Heart | 1985 |