lactic acid has been researched along with Carcinoma, Non-Small Cell Lung in 35 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 8.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| " l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment, has been known to induce tumor metastasis and drug resistance." | 4.12 | l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. ( Chen, CH; Chen, CJ; Cheng, FJ; Chiou, JY; Huang, WC; Liu, YC; Nguyen, KTL; Shen, YC; Tang, CH; Tu, CY, 2022) |
| "Targeted-therapy failure in treating nonsmall cell lung cancer (NSCLC) frequently occurs because of the emergence of drug resistance and genetic mutations." | 2.72 | Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer. ( Hsieh, CC; Kempson, IM; Liao, ZX; Tseng, SJ; Yang, PC, 2021) |
| "Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness, angiogenesis, cancer-associated inflammation and migration in NSCLC." | 1.72 | Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. ( Li, G; Ma, Y; Ren, G; Wang, X; Zheng, Z, 2022) |
| "Isovitexin (IVT) is a well-known flavone C-glycoside found in many plants and has attracted wide attention due to its obvious antitumor and antioxidant effects." | 1.62 | Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. ( Chen, RL; He, JQ; Huang, P; Sun, CH; Wang, Z; Yu, CH; Yu, WY; Zhang, HH, 2021) |
| "Radiotherapy is a key component of cancer treatment." | 1.42 | Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. ( Caster, JM; Foote, M; Hyder, SN; Lara, H; Saripalli, S; Sethi, M; Tian, X; Wagner, KT; Wang, AZ; Wang, E; Zhang, L, 2015) |
| "Clofazimine was shown to have a direct cytotoxic effect in vitro with an ID50 of 10." | 1.29 | Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. ( Fearon, KC; Plumb, JA; Sri-Pathmanathan, RM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.86) | 18.2507 |
| 2000's | 1 (2.86) | 29.6817 |
| 2010's | 19 (54.29) | 24.3611 |
| 2020's | 14 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, KTL | 1 |
| Chiou, JY | 1 |
| Liu, YC | 1 |
| Cheng, FJ | 1 |
| Shen, YC | 1 |
| Chen, CJ | 1 |
| Tang, CH | 1 |
| Huang, WC | 1 |
| Chen, CH | 1 |
| Tu, CY | 1 |
| Ren, G | 1 |
| Ma, Y | 1 |
| Wang, X | 2 |
| Zheng, Z | 1 |
| Li, G | 1 |
| Li, J | 2 |
| Wu, Z | 1 |
| Chen, G | 1 |
| Zhu, X | 1 |
| Zhang, Y | 2 |
| Zhang, R | 1 |
| Wu, W | 1 |
| Zhu, Y | 1 |
| Ma, L | 1 |
| Yu, H | 1 |
| Hao, D | 1 |
| Li, Y | 1 |
| Shi, J | 1 |
| Jiang, J | 2 |
| Liu, B | 1 |
| Zhang, J | 2 |
| Meng, X | 1 |
| Xie, SM | 1 |
| Liu, F | 1 |
| Chen, H | 1 |
| Yao, D | 1 |
| Li, M | 1 |
| Guo, M | 1 |
| Shen, H | 1 |
| Zhang, X | 1 |
| Xing, L | 1 |
| Silva, A | 1 |
| Cerqueira, MC | 1 |
| Rosa, B | 1 |
| Sobral, C | 1 |
| Pinto-Ribeiro, F | 1 |
| Costa, MF | 1 |
| Baltazar, F | 2 |
| Afonso, J | 1 |
| Tong, Z | 1 |
| Wang, Z | 4 |
| Tong, C | 1 |
| Wu, L | 1 |
| Xu, L | 1 |
| Li, K | 1 |
| Xu, F | 1 |
| Liang, S | 1 |
| Kong, Y | 1 |
| Chen, B | 1 |
| Hu, M | 1 |
| Zhao, Y | 1 |
| Cao, Y | 1 |
| Tang, Q | 1 |
| Feng, Z | 1 |
| Ni, J | 1 |
| Zhou, X | 1 |
| Wang, K | 1 |
| Huang, W | 1 |
| Chen, R | 1 |
| Lin, P | 1 |
| Zhang, T | 1 |
| Ni, YF | 1 |
| Li, H | 2 |
| Wu, J | 1 |
| Sun, XX | 1 |
| Geng, JJ | 1 |
| Zhu, YM | 1 |
| Nan, G | 1 |
| Zhang, W | 1 |
| Chen, X | 1 |
| Zhu, P | 1 |
| Bian, H | 1 |
| Chen, ZN | 1 |
| Chen, RL | 1 |
| Huang, P | 1 |
| Sun, CH | 1 |
| Yu, WY | 1 |
| Zhang, HH | 1 |
| Yu, CH | 1 |
| He, JQ | 1 |
| Xiong, B | 1 |
| Chen, Y | 2 |
| Liu, Y | 1 |
| Hu, X | 1 |
| Han, H | 2 |
| Li, Q | 2 |
| Ghergurovich, JM | 1 |
| Lang, JD | 1 |
| Levin, MK | 1 |
| Briones, N | 1 |
| Facista, SJ | 1 |
| Mueller, C | 1 |
| Cowan, AJ | 1 |
| McBride, MJ | 1 |
| Rodriguez, ESR | 1 |
| Killian, A | 1 |
| Dao, T | 1 |
| Lamont, J | 1 |
| Barron, A | 1 |
| Su, X | 1 |
| Hendricks, WPD | 1 |
| Espina, V | 1 |
| Von Hoff, DD | 1 |
| O'Shaughnessy, J | 1 |
| Rabinowitz, JD | 1 |
| Liao, ZX | 1 |
| Kempson, IM | 1 |
| Hsieh, CC | 1 |
| Tseng, SJ | 1 |
| Yang, PC | 1 |
| Faubert, B | 1 |
| Li, KY | 1 |
| Cai, L | 1 |
| Hensley, CT | 1 |
| Kim, J | 1 |
| Zacharias, LG | 1 |
| Yang, C | 1 |
| Do, QN | 1 |
| Doucette, S | 1 |
| Burguete, D | 1 |
| Huet, G | 1 |
| Yuan, Q | 1 |
| Wigal, T | 1 |
| Butt, Y | 1 |
| Ni, M | 1 |
| Torrealba, J | 1 |
| Oliver, D | 1 |
| Lenkinski, RE | 1 |
| Malloy, CR | 1 |
| Wachsmann, JW | 1 |
| Young, JD | 1 |
| Kernstine, K | 1 |
| DeBerardinis, RJ | 1 |
| Jiang, W | 1 |
| Wang, H | 1 |
| Cui, Y | 1 |
| Lei, Y | 1 |
| Wang, Y | 3 |
| Xu, D | 1 |
| Jiang, N | 1 |
| Sun, Y | 1 |
| Cao, J | 1 |
| Ke, Z | 1 |
| Wang, M | 1 |
| Wang, W | 3 |
| Wang, J | 1 |
| Hoffmann, P | 1 |
| Al-Ani, A | 1 |
| von Lueder, T | 1 |
| Hoffmann, J | 1 |
| Majak, P | 1 |
| Hagen, O | 1 |
| Loose, H | 1 |
| Kløw, NE | 1 |
| Opdahl, A | 1 |
| Muli Jogi, RK | 1 |
| Damodharan, K | 1 |
| Leong, HL | 1 |
| Tan, ACS | 1 |
| Chandramohan, S | 1 |
| Venkatanarasimha, NKK | 1 |
| Irani, FG | 1 |
| Patel, A | 1 |
| Gogna, A | 1 |
| Tay, KH | 1 |
| Urlings, TAJ | 1 |
| Magometschnigg, H | 1 |
| Pinker, K | 1 |
| Helbich, T | 1 |
| Brandstetter, A | 1 |
| Rudas, M | 1 |
| Nakuz, T | 1 |
| Baltzer, P | 1 |
| Wadsak, W | 1 |
| Hacker, M | 1 |
| Weber, M | 1 |
| Dubsky, P | 1 |
| Filipits, M | 1 |
| Rodrigues, R | 1 |
| Betelu, S | 1 |
| Colombano, S | 1 |
| Masselot, G | 1 |
| Tzedakis, T | 1 |
| Ignatiadis, I | 1 |
| Liu, X | 1 |
| Huang, Z | 1 |
| Qian, W | 1 |
| Zhang, Q | 1 |
| Sun, J | 1 |
| Schwartz, DL | 1 |
| Tagge, I | 1 |
| Powers, K | 1 |
| Ahn, S | 1 |
| Bakshi, R | 1 |
| Calabresi, PA | 1 |
| Todd Constable, R | 1 |
| Grinstead, J | 1 |
| Henry, RG | 1 |
| Nair, G | 1 |
| Papinutto, N | 1 |
| Pelletier, D | 1 |
| Shinohara, R | 1 |
| Oh, J | 1 |
| Reich, DS | 1 |
| Sicotte, NL | 1 |
| Rooney, WD | 1 |
| Elsaid Ali, AA | 1 |
| Taher, M | 1 |
| Mohamed, F | 1 |
| Granja, S | 1 |
| Marchiq, I | 1 |
| Le Floch, R | 1 |
| Moura, CS | 1 |
| Pouysségur, J | 1 |
| Jung, J | 1 |
| Song, SY | 1 |
| Yoon, SM | 1 |
| Kwak, J | 1 |
| Yoon, K | 1 |
| Choi, W | 1 |
| Jeong, SY | 1 |
| Choi, EK | 1 |
| Cho, B | 1 |
| De Rosa, V | 1 |
| Iommelli, F | 1 |
| Monti, M | 1 |
| Fonti, R | 1 |
| Votta, G | 1 |
| Stoppelli, MP | 1 |
| Del Vecchio, S | 1 |
| Ma, JJ | 1 |
| Wang, XL | 1 |
| Liu, HP | 1 |
| Cheng, X | 1 |
| Qiu, N | 1 |
| Yang, J | 2 |
| Liu, H | 1 |
| Wen, J | 1 |
| Chen, L | 1 |
| Vlachostergios, PJ | 1 |
| Oikonomou, KG | 1 |
| Gibilaro, E | 1 |
| Apergis, G | 1 |
| Tian, X | 1 |
| Lara, H | 1 |
| Wagner, KT | 1 |
| Saripalli, S | 1 |
| Hyder, SN | 1 |
| Foote, M | 1 |
| Sethi, M | 1 |
| Wang, E | 1 |
| Caster, JM | 1 |
| Zhang, L | 1 |
| Wang, AZ | 1 |
| Sambade, M | 1 |
| Deal, A | 1 |
| Schorzman, A | 1 |
| Luft, JC | 1 |
| Bowerman, C | 1 |
| Chu, K | 1 |
| Karginova, O | 1 |
| Swearingen, AV | 1 |
| Zamboni, W | 1 |
| DeSimone, J | 1 |
| Anders, CK | 1 |
| Das, J | 1 |
| Samadder, A | 1 |
| Mondal, J | 1 |
| Abraham, SK | 1 |
| Khuda-Bukhsh, AR | 1 |
| Najlah, M | 1 |
| Ahmed, Z | 1 |
| Iqbal, M | 1 |
| Tawari, P | 1 |
| McConville, C | 1 |
| Wang, C | 1 |
| Chen, J | 1 |
| Broggini-Tenzer, A | 1 |
| Vuong, V | 1 |
| Pruschy, M | 1 |
| Dong, M | 1 |
| Philippi, C | 1 |
| Loretz, B | 1 |
| Nafee, N | 1 |
| Schaefer, UF | 1 |
| Friedel, G | 1 |
| Ammon-Treiber, S | 1 |
| Griese, EU | 1 |
| Lehr, CM | 1 |
| Klotz, U | 1 |
| Mürdter, TE | 1 |
| Kowalski, W | 1 |
| Nocon, D | 1 |
| Gamian, A | 1 |
| Kołodziej, J | 1 |
| Rakus, D | 1 |
| Koukourakis, MI | 1 |
| Giatromanolaki, A | 1 |
| Sivridis, E | 1 |
| Gatter, KC | 1 |
| Harris, AL | 1 |
| Sri-Pathmanathan, RM | 1 |
| Plumb, JA | 1 |
| Fearon, KC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study To Investigate Targetable Metabolic Pathways Sustaining Triple Negative (TN) Breast Cancer and Associated Genomic Alterations[NCT03457779] | 16 participants (Actual) | Interventional | 2018-02-08 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Topics: Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Monocarboxylic Acid Transporter | 2023 |
Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer.
Topics: Anaplastic Lymphoma Kinase; Animals; Carcinoma, Non-Small-Cell Lung; Citric Acid Cycle; Drug Resista | 2021 |
2 trials available for lactic acid and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer.
Topics: Amino Acids; Carcinoma, Non-Small-Cell Lung; Glucose; Humans; Lactic Acid; Lung Neoplasms; Proteomic | 2021 |
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
31 other studies available for lactic acid and Carcinoma, Non-Small Cell Lung
| Article | Year |
|---|---|
l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters.
Topics: Acidosis, Lactic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Humans; Lactic Acid; Lung Neoplasm | 2022 |
Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation.
Topics: AMP-Activated Protein Kinases; Aspirin; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Glycolys | 2022 |
Formosanin C inhibits non-small-cell lung cancer progression by blocking MCT4/CD147-mediated lactate export.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Diosgenin; Humans; Lactic Acid | 2023 |
Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Ne | 2023 |
HDAC6-G3BP2 promotes lysosomal-TSC2 and suppresses mTORC1 under ETV4 targeting-induced low-lactate stress in non-small cell lung cancer.
Topics: Adaptor Proteins, Signal Transducing; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Histone Deac | 2023 |
A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Exosomes; Humans; Lactic Acid; Lung Neo | 2023 |
M2 macrophage exosomal LINC01001 promotes non-small cell lung cancer development by affecting METTL3 and glycolysis pathway.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Glycolysis; Lactic Acid; Lung Neoplasms; Macrophages; Mice | 2023 |
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Cell Proliferat | 2020 |
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.
Topics: Animals; Basigin; Carcinoma, Non-Small-Cell Lung; Cell Line; Humans; Lactic Acid; Lung Neoplasms; Ma | 2021 |
Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apigenin; Carcinoma, Non-Small-Cell Lung; Ca | 2021 |
Artesunate-loaded porous PLGA microsphere as a pulmonary delivery system for the treatment of non-small cell lung cancer.
Topics: Artesunate; Carcinoma, Non-Small-Cell Lung; Humans; Lactic Acid; Lung Neoplasms; Microspheres; Parti | 2021 |
Lactate Metabolism in Human Lung Tumors.
Topics: Animals; Blood Chemical Analysis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Citric Acid Cycl | 2017 |
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Count; C | 2018 |
MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells.
Topics: 3' Untranslated Regions; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Prolif | 2018 |
Topics: A549 Cells; Aged; Apoptosis; Brain; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Non-Smal | 2018 |
Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery.
Topics: Administration, Inhalation; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Carriers; Drug Co | 2013 |
Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Antineoplastic Agents; Basigin; Biological Transport; | 2015 |
Verification of Accuracy of CyberKnife Tumor-tracking Radiation Therapy Using Patient-specific Lung Phantoms.
Topics: Carcinoma, Non-Small-Cell Lung; Fiducial Markers; Humans; Lactic Acid; Lung; Lung Neoplasms; Medical | 2015 |
Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; ErbB Recep | 2015 |
[Metabolomics Study on Non-Small Cell Lung Cancer Patients with Different Chinese Medical Syndromes].
Topics: Asian People; Carcinoma, Non-Small-Cell Lung; Gas Chromatography-Mass Spectrometry; Humans; Lactic A | 2015 |
Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell | 2015 |
Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; DNA Breaks, Double-Stranded; Drug Carriers; Drug Delivery S | 2015 |
Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2016 |
Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction.
Topics: Animals; Antineoplastic Agents; Antioxidants; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chlo | 2016 |
Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disulfiram; Humans; Lactic Acid; Lung Neoplasms; M | 2017 |
Disulfiram-loaded porous PLGA microparticle for inhibiting the proliferation and migration of non-small-cell lung cancer.
Topics: Administration, Inhalation; Alcohol Deterrents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; C | 2017 |
Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epothilones; Glyc | 2011 |
Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.
Topics: Carcinoma, Non-Small-Cell Lung; Chitosan; Humans; Lactic Acid; Lung Neoplasms; Nanoparticles; Polygl | 2011 |
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N | 2012 |
Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
Topics: Autopsy; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Fibroblasts; Humans; Hypoxia-Inducible Factor | 2005 |
Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carcinoma, Non-Small-Cell Lung; Cell Divisio | 1994 |