Page last updated: 2024-10-17

lactic acid and Carcinoma, Epidermoid

lactic acid has been researched along with Carcinoma, Epidermoid in 60 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors."5.37Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011)
"Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers."3.75Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009)
" We report here the results of the implantation of a novel biodegradable poly-L-lactic acid (PLLA) esophageal stent in two patients with benign esophageal stenosis after endoscopic submucosal dissection (ESD)."3.74Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. ( Andoh, A; Fujiyama, Y; Hata, K; Minematsu, H; Murata, K; Nitta, N; Saito, Y; Tanaka, T; Tsujikawa, T, 2008)
"Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive."1.91F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023)
"Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis."1.91Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023)
"The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts."1.51Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. ( Chen, Y; Huang, C; Jiang, E; Liu, K; Liu, Q; Shang, Z; Shao, Z; Wang, H; Wang, L; Wang, M; Xu, Z; Yan, T; Zhou, X, 2019)
"Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate."1.51Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019)
"Oral squamous cell carcinoma (HSC-2, HSC-3) and normal (HaCaT) cells were used."1.46Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH. ( Kitamura, J; Morishima, H; Shinohara, Y; Takahashi, N; Takahashi, T; Washio, J, 2017)
"Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis."1.46Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017)
"Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up."1.43Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016)
"The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively."1.43STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016)
"Oral squamous cell carcinoma (OSCC) is the sixth most common human malignancy."1.43Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype. ( Dhupar, A; Saluja, TS; Spadigam, A; Syed, S, 2016)
"Herein, we analyzed biopsies of primary squamous cell carcinoma after surgery and adjuvant irradiation in 17 patients."1.43Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years. ( Blatt, S; Mueller-Klieser, W; Pabst, AM; Sagheb, K; Schroeder, T; Voelxen, N; Walenta, S; Ziebart, T, 2016)
"Oral squamous cell carcinoma (OSCC) or cancers of oral cavity is one of the most common cancers worldwide with high rate of mortality and morbidity."1.42A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy. ( Huo, ZJ; Li, XC; Liu, K; Liu, P; Pang, B; Wang, M; Wang, SJ; Wang, ZQ, 2015)
"In head and neck squamous cell carcinoma (HNSCC) aerobic glycolysis is the key feature for energy supply of the tumor."1.39Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. ( Himpe, B; Nitsch, S; Pries, R; Schroeder, U; Vonthein, R; Wollenberg, B, 2013)
"A high lactate content in malignant head and neck cancer (Head and neck squamous cell carcinomas, HNSCC) is associated with a higher risk of metastatic spread and lower overall patient survival."1.37Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue. ( Kunkel, M; Mueller-Klieser, W; Reichert, TE; Wagner, W; Walenta, S; Ziebart, T, 2011)
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors."1.37Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011)
"Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed."1.33Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. ( Bezabeh, T; Kerr, P; Nason, R; Odlum, O; Patel, R; Smith, IC; Sutherland, D, 2005)
"Five human head and neck squamous cell carcinoma cell lines (HNSCCs) xenografted in nude mice were treated with a clinically relevant irradiation protocol with 30 fractions within 6 weeks."1.33Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. ( Baumann, M; Mueller-Klieser, W; Quennet, V; Rosner, A; Walenta, S; Yaromina, A; Zips, D, 2006)
"A total of 22 NZW rabbits with VX2 squamous cell carcinomas transplanted into the auricles were intra-arterially (i."1.31Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits. ( Dullens, HF; Koole, R; Nijsen, JF; Slootweg, PJ; van Es, RJ; van het Schip, AD, 2001)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.67)18.7374
1990's2 (3.33)18.2507
2000's17 (28.33)29.6817
2010's37 (61.67)24.3611
2020's3 (5.00)2.80

Authors

AuthorsStudies
Nakashima, C1
Fujiwara-Tani, R1
Mori, S1
Kishi, S1
Ohmori, H1
Fujii, K1
Mori, T1
Miyagawa, Y1
Yamamoto, K1
Kirita, T1
Luo, Y1
Kuniyasu, H1
Sun, J1
Tang, Q1
Yu, S1
Xie, M2
Zheng, W1
Chen, G2
Yin, Y1
Huang, X1
Wo, K1
Lei, H1
Zhang, J2
Wan, Q1
Chen, L1
Lin, Y1
Qi, Y1
Jiang, M1
Huang, W1
Li, B1
Ohashi, T1
Aoki, M1
Tomita, H1
Akazawa, T1
Sato, K1
Kuze, B1
Mizuta, K1
Hara, A1
Nagaoka, H1
Inoue, N1
Ito, Y1
Morishima, H1
Washio, J1
Kitamura, J1
Shinohara, Y1
Takahashi, T1
Takahashi, N1
Nieto, K1
Pei, P1
Wang, D1
Mallery, SR1
Schwendeman, SP1
Wu, J1
Hong, Y1
Wu, T1
Wang, J1
Chen, X1
Wang, Z1
Cheng, B1
Xia, J1
Mao, X1
Zhu, H2
Luo, D1
Ye, L1
Yin, H1
Zhang, Y2
Yu, W1
Chen, Y4
Dubrulle, J1
Stossi, F1
Putluri, V1
Sreekumar, A1
Putluri, N1
Baluya, D1
Lai, SY3
Sandulache, VC4
Jiang, E1
Xu, Z1
Wang, M2
Yan, T1
Huang, C1
Zhou, X1
Liu, Q1
Wang, L1
Wang, H2
Liu, K2
Shao, Z1
Shang, Z1
Stone, SC1
Rossetti, RAM1
Alvarez, KLF1
Carvalho, JP1
Margarido, PFR1
Baracat, EC1
Tacla, M1
Boccardo, E1
Yokochi, K1
Lorenzi, NP1
Lepique, AP1
Zhao, H1
Hu, CY1
Chen, WM1
Huang, P1
Goetze, K1
Meyer, SS2
Yaromina, A5
Zips, D5
Baumann, M5
Mueller-Klieser, W8
Schroeder, U1
Himpe, B1
Pries, R1
Vonthein, R1
Nitsch, S1
Wollenberg, B1
Clatot, F1
Gouérant, S1
Mareschal, S1
Cornic, M1
Berghian, A1
Choussy, O1
El Ouakif, F1
François, A1
Bénard, M1
Ruminy, P1
Picquenot, JM1
Jardin, F1
Wang, X2
Shi, L1
Tu, Q1
Zhang, H2
Wang, P1
Zhang, L1
Huang, Z1
Zhao, F1
Luan, H1
Saito, K2
Matsumoto, S1
Takakusagi, Y1
Matsuo, M1
Morris, HD1
Lizak, MJ1
Munasinghe, JP1
Devasahayam, N1
Subramanian, S1
Mitchell, JB1
Krishna, MC2
Pradhan, R1
Ramasamy, T1
Choi, JY1
Kim, JH1
Poudel, BK1
Tak, JW1
Nukolova, N1
Choi, HG1
Yong, CS1
Kim, JO1
Skinner, HD2
Lu, T1
Feng, L3
Court, LE1
Myers, JN3
Meyn, RE2
Fuller, CD2
Bankson, JA2
Grimm, M1
Krimmel, M1
Hoefert, S1
Kraut, W1
Calgéer, B1
Biegner, T1
Teriete, P1
Munz, A1
Reinert, S1
Vlachostergios, PJ1
Oikonomou, KG1
Gibilaro, E1
Apergis, G1
Wang, ZQ1
Huo, ZJ1
Li, XC1
Liu, P1
Pang, B1
Wang, SJ1
Xu, P1
Li, Y1
Li, M1
Silva, LS1
Goncalves, LG1
Silva, F1
Domingues, G1
Maximo, V1
Ferreira, J1
Lam, EW1
Dias, S1
Felix, A1
Serpa, J1
Saluja, TS1
Spadigam, A1
Dhupar, A1
Syed, S1
Blatt, S1
Voelxen, N1
Sagheb, K1
Pabst, AM1
Walenta, S7
Schroeder, T3
Ziebart, T2
Masloub, SM1
Elmalahy, MH1
Sabry, D1
Mohamed, WS1
Ahmed, SH1
Xu, Q1
Zhang, Q1
Ishida, Y1
Hajjar, S1
Tang, X1
Shi, H1
Dang, CV1
Le, AD1
Li, HM1
Yang, JG1
Liu, ZJ1
Wang, WM1
Yu, ZL1
Ren, JG1
Zhang, W1
Jia, J1
Neveu, MA1
De Preter, G1
Joudiou, N1
Bol, A1
Brender, JR1
Kishimoto, S1
Grégoire, V1
Jordan, BF1
Feron, O1
Gallez, B1
William, WN1
Li, J1
Mijiti, A1
Konopleva, MY1
Wigfield, SM1
Winter, SC1
Giatromanolaki, A1
Taylor, J1
Koukourakis, ML1
Harris, AL1
Melkus, G2
Mörchel, P2
Behr, VC1
Kotas, M1
Flentje, M2
Jakob, PM2
Ping, Y1
Jian, Z1
Yi, Z1
Huoyu, Z1
Yuqiong, Y1
Shixi, L1
Quennet, V3
Meyer, S1
Shakirin, G1
Sattler, UG1
Hoerner, C1
Knoerzer, H1
Fabian, C1
Kunkel, M1
Reichert, TE1
Wagner, W1
Lee, SM1
Park, H1
Yoo, KH1
Mochizuki, Y1
Saito, Y2
Tanaka, T2
Nitta, N2
Yamada, H1
Tsujikawa, T2
Murata, K2
Fujiyama, Y2
Andoh, A2
Ho, VW1
Leung, K1
Hsu, A1
Luk, B1
Lai, J1
Shen, SY1
Minchinton, AI1
Waterhouse, D1
Bally, MB1
Lin, W1
Nelson, BH1
Sly, LM1
Krystal, G1
Ow, TJ1
Pickering, CR1
Frederick, MJ1
Zhou, G1
Fokt, I1
Davis-Malesevich, M1
Priebe, W1
Kowalski, W1
Nocon, D1
Gamian, A1
Kołodziej, J1
Rakus, D1
Yang, K3
Wen, Y3
Li, L1
Wang, C3
Hou, S1
Li, C1
MOIROUD, P1
BONNEAU, H1
Bezabeh, T1
Odlum, O1
Nason, R1
Kerr, P1
Sutherland, D1
Patel, R1
Smith, IC1
Rosner, A1
Zhou, L1
Hu, T1
Yao, M1
Minematsu, H1
Hata, K1
Le, QT1
Koong, A1
Lieskovsky, YY1
Narasimhan, B1
Graves, E1
Pinto, H1
Brown, JM2
Spielman, D1
Tamulevicius, P1
Streffer, C2
Egilmez, NK1
Jong, YS1
Iwanuma, Y1
Jacob, JS1
Santos, CA1
Chen, FA1
Mathiowitz, E1
Bankert, RB1
Star-Lack, JM1
Adalsteinsson, E1
Adam, MF1
Terris, DJ1
Pinto, HA1
Spielman, DM1
Smith, TA1
Titley, J1
Dwarkanath, BS1
Zolzer, F1
Chandana, S1
Bauch, T1
Adhikari, JS1
Muller, WU1
Jain, V1
Brizel, DM1
Scher, RL1
Clough, RW1
Dewhirst, MW1
van Es, RJ1
Nijsen, JF1
van het Schip, AD1
Dullens, HF1
Slootweg, PJ1
Koole, R1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284]Phase 240 participants (Anticipated)Interventional2022-07-01Recruiting
Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer[NCT00140556]Early Phase 128 participants (Actual)Interventional2005-08-31Completed
Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue[NCT02975739]1 participants (Actual)Interventional2016-09-30Terminated (stopped due to Slow accrual)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Tumor Resolution

Complete response (resolution) of tumor on clinical exam. (NCT00140556)
Timeframe: Within 30 days of completing RT

InterventionParticipants (Number)
Entire Study Population25

Trials

3 trials available for lactic acid and Carcinoma, Epidermoid

ArticleYear
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
    Cancer biomarkers : section A of Disease markers, 2015, Volume: 15, Issue:6

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm

2015
[Clinical application of anticancer nanoparticles targeting metastasis foci of cervical lymph nodes in patients with oral carcinoma].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2003, Volume: 21, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Chromatography, High Press

2003
In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.
    AJNR. American journal of neuroradiology, 2000, Volume: 21, Issue:1

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Choline; Creatine; Head and Neck Neoplasms; Humans; Lactic Ac

2000

Other Studies

57 other studies available for lactic acid and Carcinoma, Epidermoid

ArticleYear
An Axis between the Long Non-Coding RNA
    International journal of molecular sciences, 2022, Sep-14, Volume: 23, Issue:18

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavin-Adenine Dinucleotide

2022
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
    EBioMedicine, 2023, Volume: 88

    Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop

2023
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
    International immunopharmacology, 2023, Volume: 124, Issue:Pt B

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas

2023
M2-like macrophage polarization in high lactic acid-producing head and neck cancer.
    Cancer science, 2017, Volume: 108, Issue:6

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Squamous Cell

2017
Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.
    Scientific reports, 2017, 08-30, Volume: 7, Issue:1

    Topics: Acids; Ammonia; Antimetabolites; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Deoxyglucose

2017
In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence.
    International journal of pharmaceutics, 2018, Mar-01, Volume: 538, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoprevention; Delay

2018
Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma.
    International journal of molecular medicine, 2018, Volume: 41, Issue:2

    Topics: Actins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Fibrob

2018
Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression.
    Molecular medicine reports, 2018, Volume: 17, Issue:4

    Topics: Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Eso

2018
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.
    Scientific reports, 2018, 03-09, Volume: 8, Issue:1

    Topics: Animals; Antineoplastic Agents; Carbon; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Citri

2018
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:4

    Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Caveolin 1; Cell Line, Tumor; Cocu

2019
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
    Journal of leukocyte biology, 2019, Volume: 105, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur

2019
Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma.
    Current medical science, 2019, Volume: 39, Issue:3

    Topics: AC133 Antigen; Aged; Axin Protein; Carcinoma, Squamous Cell; Cell Proliferation; Female; Gene Expres

2019
Glycolysis-related gene induction and ATP reduction during fractionated irradiation. Markers for radiation responsiveness of human tumor xenografts.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2013, Volume: 189, Issue:9

    Topics: Adenosine Triphosphate; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose

2013
Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer.
    Nutrition and cancer, 2013, Volume: 65, Issue:6

    Topics: Aged; Carcinoma, Squamous Cell; Circadian Rhythm; Diet, Ketogenic; Female; Glucose; Head and Neck Ne

2013
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
    Oral oncology, 2014, Volume: 50, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal

2014
Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Lactic Acid; Mice; Mice, Hairless; Nanoparti

2015
13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Nov-15, Volume: 21, Issue:22

    Topics: Animals; Carbon Isotopes; Carcinoma, Squamous Cell; Colonic Neoplasms; HT29 Cells; Humans; Lactic Ac

2015
Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin.
    Carbohydrate polymers, 2015, Jun-05, Volume: 123

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Body Weight; Carcinoma, Squamous Cell; Cell Line, Tum

2015
Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:12

    Topics: Animals; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Line, Tu

2015
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2016, Volume: 45, Issue:5

    Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno

2016
A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy.
    Journal of nanobiotechnology, 2015, Oct-01, Volume: 13

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dr

2015
MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2016, Volume: 74, Issue:4

    Topics: Carcinoma, Squamous Cell; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelia

2016
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:4

    Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe

2016
Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:4

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Epithelial Cells; Female; Humans; Isoenzymes; L-Lactate Dehyd

2016
Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years.
    Clinical oral investigations, 2016, Volume: 20, Issue:8

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neopla

2016
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
    Archives of oral biology, 2016, Volume: 64

    Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug

2016
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
    Oncotarget, 2017, Feb-07, Volume: 8, Issue:6

    Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti

2017
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
    Journal of experimental & clinical cancer research : CR, 2017, 01-07, Volume: 36, Issue:1

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor;

2017
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam

2016
Metabolic interrogation as a tool to optimize chemotherapeutic regimens.
    Oncotarget, 2017, Mar-14, Volume: 8, Issue:11

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug

2017
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
    British journal of cancer, 2008, Jun-17, Volume: 98, Issue:12

    Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec

2008
Short-echo spectroscopic imaging combined with lactate editing in a single scan.
    NMR in biomedicine, 2008, Volume: 21, Issue:10

    Topics: Animals; Carcinoma, Squamous Cell; Complex Mixtures; Feasibility Studies; Humans; Lactic Acid; Lipid

2008
Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:3

    Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Combined Modality Therapy; Drug Comp

2010
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
    International journal of radiation biology, 2009, Volume: 85, Issue:11

    Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluo

2009
Glycolytic metabolism and tumour response to fractionated irradiation.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 94, Issue:1

    Topics: Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose Fractionation, Rad

2010
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
    Journal of cancer research and clinical oncology, 2011, Volume: 137, Issue:2

    Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcin

2011
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 96, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiati

2010
Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles.
    Advanced materials (Deerfield Beach, Fla.), 2010, Sep-22, Volume: 22, Issue:36

    Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Contrast Media; Doxorubicin; Drug Carriers; Fem

2010
Endoscopic submucosal dissection combined with the placement of biodegradable stents for recurrent esophageal cancer after chemoradiotherapy.
    Journal of gastrointestinal cancer, 2012, Volume: 43, Issue:2

    Topics: Absorbable Implants; Carcinoma, Squamous Cell; Chemoradiotherapy; Esophageal Neoplasms; Esophageal S

2012
A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.
    Cancer research, 2011, Jul-01, Volume: 71, Issue:13

    Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Squamous Cell; Cell Growth Processes; Dietary Carboh

2011
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
    Cancer, 2011, Jul-01, Volume: 117, Issue:13

    Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol

2011
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
    Journal of cellular physiology, 2012, Volume: 227, Issue:6

    Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N

2012
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
    International journal of radiation oncology, biology, physics, 2002, Dec-01, Volume: 54, Issue:5

    Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen

2002
[Preparation of cucurbitacinBE polylactic acid nano-particles for targeting cervical lymph nodes].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2001, Volume: 19, Issue:6

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems;

2001
[Excision of a cervical metastasis of an undiscovered spinocellular malpighian epithelioma: absence of recurrence 12 years later, failure to lactate the primary lesion].
    La Presse medicale, 1955, Oct-29, Volume: 63, Issue:71

    Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Lactic Acid; Neoplasm Recurrence, Local;

1955
[The study of cucurbitacin BE polylactic acid nanoparticles delivering cucurbitacin BE to metastasized cervical lymph nodes in mice with oral cancer].
    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2003, Volume: 21, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cucurbitacins; Delayed-Action

2003
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:8

    Topics: Carcinoma, Squamous Cell; Choline; Creatine; Female; Head and Neck Neoplasms; Humans; Lactic Acid; L

2005
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 81, Issue:2

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Fe

2006
Intratumoral delivery of paclitaxel-loaded poly(lactic-co-glycolic acid) microspheres for Hep-2 laryngeal squamous cell carcinoma xenografts.
    Anti-cancer drugs, 2007, Volume: 18, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Capillaries; Carcinoma, Squamou

2007
Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:2

    Topics: Absorbable Implants; Carcinoma, Squamous Cell; Digestive System Surgical Procedures; Dissection; End

2008
In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma.
    International journal of radiation oncology, biology, physics, 2008, Jul-15, Volume: 71, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck N

2008
Metabolic imaging in tumours by means of bioluminescence.
    British journal of cancer, 1995, Volume: 72, Issue:5

    Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne

1995
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
    Cancer immunology, immunotherapy : CII, 1998, Volume: 46, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter

1998
Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction.
    International journal of radiation oncology, biology, physics, 2000, Apr-01, Volume: 47, Issue:1

    Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Count; Fluorodeoxyglucose F18; Head and Neck Neoplasms; H

2000
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
    International journal of radiation oncology, biology, physics, 2001, Jul-15, Volume: 50, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D

2001
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2001, Oct-01, Volume: 51, Issue:2

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm

2001
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2001, Oct-01, Volume: 51, Issue:2

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm

2001
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2001, Oct-01, Volume: 51, Issue:2

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm

2001
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2001, Oct-01, Volume: 51, Issue:2

    Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm

2001
Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits.
    International journal of oral and maxillofacial surgery, 2001, Volume: 30, Issue:5

    Topics: Animals; Arteries; Brachytherapy; Carcinoma, Squamous Cell; Ear, External; Embolization, Therapeutic

2001