lactic acid has been researched along with Carcinoma, Epidermoid in 60 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Excerpt | Relevance | Reference |
---|---|---|
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 5.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
"Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers." | 3.75 | Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009) |
" We report here the results of the implantation of a novel biodegradable poly-L-lactic acid (PLLA) esophageal stent in two patients with benign esophageal stenosis after endoscopic submucosal dissection (ESD)." | 3.74 | Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. ( Andoh, A; Fujiyama, Y; Hata, K; Minematsu, H; Murata, K; Nitta, N; Saito, Y; Tanaka, T; Tsujikawa, T, 2008) |
"Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive." | 1.91 | F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023) |
"Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis." | 1.91 | Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023) |
"The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts." | 1.51 | Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. ( Chen, Y; Huang, C; Jiang, E; Liu, K; Liu, Q; Shang, Z; Shao, Z; Wang, H; Wang, L; Wang, M; Xu, Z; Yan, T; Zhou, X, 2019) |
"Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate." | 1.51 | Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019) |
"Oral squamous cell carcinoma (HSC-2, HSC-3) and normal (HaCaT) cells were used." | 1.46 | Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH. ( Kitamura, J; Morishima, H; Shinohara, Y; Takahashi, N; Takahashi, T; Washio, J, 2017) |
"Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis." | 1.46 | Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017) |
"Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up." | 1.43 | Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016) |
"The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively." | 1.43 | STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016) |
"Oral squamous cell carcinoma (OSCC) is the sixth most common human malignancy." | 1.43 | Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype. ( Dhupar, A; Saluja, TS; Spadigam, A; Syed, S, 2016) |
"Herein, we analyzed biopsies of primary squamous cell carcinoma after surgery and adjuvant irradiation in 17 patients." | 1.43 | Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years. ( Blatt, S; Mueller-Klieser, W; Pabst, AM; Sagheb, K; Schroeder, T; Voelxen, N; Walenta, S; Ziebart, T, 2016) |
"Oral squamous cell carcinoma (OSCC) or cancers of oral cavity is one of the most common cancers worldwide with high rate of mortality and morbidity." | 1.42 | A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy. ( Huo, ZJ; Li, XC; Liu, K; Liu, P; Pang, B; Wang, M; Wang, SJ; Wang, ZQ, 2015) |
"In head and neck squamous cell carcinoma (HNSCC) aerobic glycolysis is the key feature for energy supply of the tumor." | 1.39 | Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. ( Himpe, B; Nitsch, S; Pries, R; Schroeder, U; Vonthein, R; Wollenberg, B, 2013) |
"A high lactate content in malignant head and neck cancer (Head and neck squamous cell carcinomas, HNSCC) is associated with a higher risk of metastatic spread and lower overall patient survival." | 1.37 | Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue. ( Kunkel, M; Mueller-Klieser, W; Reichert, TE; Wagner, W; Walenta, S; Ziebart, T, 2011) |
"A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 1.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
"Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed." | 1.33 | Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. ( Bezabeh, T; Kerr, P; Nason, R; Odlum, O; Patel, R; Smith, IC; Sutherland, D, 2005) |
"Five human head and neck squamous cell carcinoma cell lines (HNSCCs) xenografted in nude mice were treated with a clinically relevant irradiation protocol with 30 fractions within 6 weeks." | 1.33 | Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. ( Baumann, M; Mueller-Klieser, W; Quennet, V; Rosner, A; Walenta, S; Yaromina, A; Zips, D, 2006) |
"A total of 22 NZW rabbits with VX2 squamous cell carcinomas transplanted into the auricles were intra-arterially (i." | 1.31 | Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits. ( Dullens, HF; Koole, R; Nijsen, JF; Slootweg, PJ; van Es, RJ; van het Schip, AD, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (1.67) | 18.7374 |
1990's | 2 (3.33) | 18.2507 |
2000's | 17 (28.33) | 29.6817 |
2010's | 37 (61.67) | 24.3611 |
2020's | 3 (5.00) | 2.80 |
Authors | Studies |
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Nakashima, C | 1 |
Fujiwara-Tani, R | 1 |
Mori, S | 1 |
Kishi, S | 1 |
Ohmori, H | 1 |
Fujii, K | 1 |
Mori, T | 1 |
Miyagawa, Y | 1 |
Yamamoto, K | 1 |
Kirita, T | 1 |
Luo, Y | 1 |
Kuniyasu, H | 1 |
Sun, J | 1 |
Tang, Q | 1 |
Yu, S | 1 |
Xie, M | 2 |
Zheng, W | 1 |
Chen, G | 2 |
Yin, Y | 1 |
Huang, X | 1 |
Wo, K | 1 |
Lei, H | 1 |
Zhang, J | 2 |
Wan, Q | 1 |
Chen, L | 1 |
Lin, Y | 1 |
Qi, Y | 1 |
Jiang, M | 1 |
Huang, W | 1 |
Li, B | 1 |
Ohashi, T | 1 |
Aoki, M | 1 |
Tomita, H | 1 |
Akazawa, T | 1 |
Sato, K | 1 |
Kuze, B | 1 |
Mizuta, K | 1 |
Hara, A | 1 |
Nagaoka, H | 1 |
Inoue, N | 1 |
Ito, Y | 1 |
Morishima, H | 1 |
Washio, J | 1 |
Kitamura, J | 1 |
Shinohara, Y | 1 |
Takahashi, T | 1 |
Takahashi, N | 1 |
Nieto, K | 1 |
Pei, P | 1 |
Wang, D | 1 |
Mallery, SR | 1 |
Schwendeman, SP | 1 |
Wu, J | 1 |
Hong, Y | 1 |
Wu, T | 1 |
Wang, J | 1 |
Chen, X | 1 |
Wang, Z | 1 |
Cheng, B | 1 |
Xia, J | 1 |
Mao, X | 1 |
Zhu, H | 2 |
Luo, D | 1 |
Ye, L | 1 |
Yin, H | 1 |
Zhang, Y | 2 |
Yu, W | 1 |
Chen, Y | 4 |
Dubrulle, J | 1 |
Stossi, F | 1 |
Putluri, V | 1 |
Sreekumar, A | 1 |
Putluri, N | 1 |
Baluya, D | 1 |
Lai, SY | 3 |
Sandulache, VC | 4 |
Jiang, E | 1 |
Xu, Z | 1 |
Wang, M | 2 |
Yan, T | 1 |
Huang, C | 1 |
Zhou, X | 1 |
Liu, Q | 1 |
Wang, L | 1 |
Wang, H | 2 |
Liu, K | 2 |
Shao, Z | 1 |
Shang, Z | 1 |
Stone, SC | 1 |
Rossetti, RAM | 1 |
Alvarez, KLF | 1 |
Carvalho, JP | 1 |
Margarido, PFR | 1 |
Baracat, EC | 1 |
Tacla, M | 1 |
Boccardo, E | 1 |
Yokochi, K | 1 |
Lorenzi, NP | 1 |
Lepique, AP | 1 |
Zhao, H | 1 |
Hu, CY | 1 |
Chen, WM | 1 |
Huang, P | 1 |
Goetze, K | 1 |
Meyer, SS | 2 |
Yaromina, A | 5 |
Zips, D | 5 |
Baumann, M | 5 |
Mueller-Klieser, W | 8 |
Schroeder, U | 1 |
Himpe, B | 1 |
Pries, R | 1 |
Vonthein, R | 1 |
Nitsch, S | 1 |
Wollenberg, B | 1 |
Clatot, F | 1 |
Gouérant, S | 1 |
Mareschal, S | 1 |
Cornic, M | 1 |
Berghian, A | 1 |
Choussy, O | 1 |
El Ouakif, F | 1 |
François, A | 1 |
Bénard, M | 1 |
Ruminy, P | 1 |
Picquenot, JM | 1 |
Jardin, F | 1 |
Wang, X | 2 |
Shi, L | 1 |
Tu, Q | 1 |
Zhang, H | 2 |
Wang, P | 1 |
Zhang, L | 1 |
Huang, Z | 1 |
Zhao, F | 1 |
Luan, H | 1 |
Saito, K | 2 |
Matsumoto, S | 1 |
Takakusagi, Y | 1 |
Matsuo, M | 1 |
Morris, HD | 1 |
Lizak, MJ | 1 |
Munasinghe, JP | 1 |
Devasahayam, N | 1 |
Subramanian, S | 1 |
Mitchell, JB | 1 |
Krishna, MC | 2 |
Pradhan, R | 1 |
Ramasamy, T | 1 |
Choi, JY | 1 |
Kim, JH | 1 |
Poudel, BK | 1 |
Tak, JW | 1 |
Nukolova, N | 1 |
Choi, HG | 1 |
Yong, CS | 1 |
Kim, JO | 1 |
Skinner, HD | 2 |
Lu, T | 1 |
Feng, L | 3 |
Court, LE | 1 |
Myers, JN | 3 |
Meyn, RE | 2 |
Fuller, CD | 2 |
Bankson, JA | 2 |
Grimm, M | 1 |
Krimmel, M | 1 |
Hoefert, S | 1 |
Kraut, W | 1 |
Calgéer, B | 1 |
Biegner, T | 1 |
Teriete, P | 1 |
Munz, A | 1 |
Reinert, S | 1 |
Vlachostergios, PJ | 1 |
Oikonomou, KG | 1 |
Gibilaro, E | 1 |
Apergis, G | 1 |
Wang, ZQ | 1 |
Huo, ZJ | 1 |
Li, XC | 1 |
Liu, P | 1 |
Pang, B | 1 |
Wang, SJ | 1 |
Xu, P | 1 |
Li, Y | 1 |
Li, M | 1 |
Silva, LS | 1 |
Goncalves, LG | 1 |
Silva, F | 1 |
Domingues, G | 1 |
Maximo, V | 1 |
Ferreira, J | 1 |
Lam, EW | 1 |
Dias, S | 1 |
Felix, A | 1 |
Serpa, J | 1 |
Saluja, TS | 1 |
Spadigam, A | 1 |
Dhupar, A | 1 |
Syed, S | 1 |
Blatt, S | 1 |
Voelxen, N | 1 |
Sagheb, K | 1 |
Pabst, AM | 1 |
Walenta, S | 7 |
Schroeder, T | 3 |
Ziebart, T | 2 |
Masloub, SM | 1 |
Elmalahy, MH | 1 |
Sabry, D | 1 |
Mohamed, WS | 1 |
Ahmed, SH | 1 |
Xu, Q | 1 |
Zhang, Q | 1 |
Ishida, Y | 1 |
Hajjar, S | 1 |
Tang, X | 1 |
Shi, H | 1 |
Dang, CV | 1 |
Le, AD | 1 |
Li, HM | 1 |
Yang, JG | 1 |
Liu, ZJ | 1 |
Wang, WM | 1 |
Yu, ZL | 1 |
Ren, JG | 1 |
Zhang, W | 1 |
Jia, J | 1 |
Neveu, MA | 1 |
De Preter, G | 1 |
Joudiou, N | 1 |
Bol, A | 1 |
Brender, JR | 1 |
Kishimoto, S | 1 |
Grégoire, V | 1 |
Jordan, BF | 1 |
Feron, O | 1 |
Gallez, B | 1 |
William, WN | 1 |
Li, J | 1 |
Mijiti, A | 1 |
Konopleva, MY | 1 |
Wigfield, SM | 1 |
Winter, SC | 1 |
Giatromanolaki, A | 1 |
Taylor, J | 1 |
Koukourakis, ML | 1 |
Harris, AL | 1 |
Melkus, G | 2 |
Mörchel, P | 2 |
Behr, VC | 1 |
Kotas, M | 1 |
Flentje, M | 2 |
Jakob, PM | 2 |
Ping, Y | 1 |
Jian, Z | 1 |
Yi, Z | 1 |
Huoyu, Z | 1 |
Yuqiong, Y | 1 |
Shixi, L | 1 |
Quennet, V | 3 |
Meyer, S | 1 |
Shakirin, G | 1 |
Sattler, UG | 1 |
Hoerner, C | 1 |
Knoerzer, H | 1 |
Fabian, C | 1 |
Kunkel, M | 1 |
Reichert, TE | 1 |
Wagner, W | 1 |
Lee, SM | 1 |
Park, H | 1 |
Yoo, KH | 1 |
Mochizuki, Y | 1 |
Saito, Y | 2 |
Tanaka, T | 2 |
Nitta, N | 2 |
Yamada, H | 1 |
Tsujikawa, T | 2 |
Murata, K | 2 |
Fujiyama, Y | 2 |
Andoh, A | 2 |
Ho, VW | 1 |
Leung, K | 1 |
Hsu, A | 1 |
Luk, B | 1 |
Lai, J | 1 |
Shen, SY | 1 |
Minchinton, AI | 1 |
Waterhouse, D | 1 |
Bally, MB | 1 |
Lin, W | 1 |
Nelson, BH | 1 |
Sly, LM | 1 |
Krystal, G | 1 |
Ow, TJ | 1 |
Pickering, CR | 1 |
Frederick, MJ | 1 |
Zhou, G | 1 |
Fokt, I | 1 |
Davis-Malesevich, M | 1 |
Priebe, W | 1 |
Kowalski, W | 1 |
Nocon, D | 1 |
Gamian, A | 1 |
Kołodziej, J | 1 |
Rakus, D | 1 |
Yang, K | 3 |
Wen, Y | 3 |
Li, L | 1 |
Wang, C | 3 |
Hou, S | 1 |
Li, C | 1 |
MOIROUD, P | 1 |
BONNEAU, H | 1 |
Bezabeh, T | 1 |
Odlum, O | 1 |
Nason, R | 1 |
Kerr, P | 1 |
Sutherland, D | 1 |
Patel, R | 1 |
Smith, IC | 1 |
Rosner, A | 1 |
Zhou, L | 1 |
Hu, T | 1 |
Yao, M | 1 |
Minematsu, H | 1 |
Hata, K | 1 |
Le, QT | 1 |
Koong, A | 1 |
Lieskovsky, YY | 1 |
Narasimhan, B | 1 |
Graves, E | 1 |
Pinto, H | 1 |
Brown, JM | 2 |
Spielman, D | 1 |
Tamulevicius, P | 1 |
Streffer, C | 2 |
Egilmez, NK | 1 |
Jong, YS | 1 |
Iwanuma, Y | 1 |
Jacob, JS | 1 |
Santos, CA | 1 |
Chen, FA | 1 |
Mathiowitz, E | 1 |
Bankert, RB | 1 |
Star-Lack, JM | 1 |
Adalsteinsson, E | 1 |
Adam, MF | 1 |
Terris, DJ | 1 |
Pinto, HA | 1 |
Spielman, DM | 1 |
Smith, TA | 1 |
Titley, J | 1 |
Dwarkanath, BS | 1 |
Zolzer, F | 1 |
Chandana, S | 1 |
Bauch, T | 1 |
Adhikari, JS | 1 |
Muller, WU | 1 |
Jain, V | 1 |
Brizel, DM | 1 |
Scher, RL | 1 |
Clough, RW | 1 |
Dewhirst, MW | 1 |
van Es, RJ | 1 |
Nijsen, JF | 1 |
van het Schip, AD | 1 |
Dullens, HF | 1 |
Slootweg, PJ | 1 |
Koole, R | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer[NCT00140556] | Early Phase 1 | 28 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue[NCT02975739] | 1 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Slow accrual) | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Complete response (resolution) of tumor on clinical exam. (NCT00140556)
Timeframe: Within 30 days of completing RT
Intervention | Participants (Number) |
---|---|
Entire Study Population | 25 |
3 trials available for lactic acid and Carcinoma, Epidermoid
Article | Year |
---|---|
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
[Clinical application of anticancer nanoparticles targeting metastasis foci of cervical lymph nodes in patients with oral carcinoma].
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Chromatography, High Press | 2003 |
In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Choline; Creatine; Head and Neck Neoplasms; Humans; Lactic Ac | 2000 |
57 other studies available for lactic acid and Carcinoma, Epidermoid
Article | Year |
---|---|
An Axis between the Long Non-Coding RNA
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavin-Adenine Dinucleotide | 2022 |
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop | 2023 |
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas | 2023 |
M2-like macrophage polarization in high lactic acid-producing head and neck cancer.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Squamous Cell | 2017 |
Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.
Topics: Acids; Ammonia; Antimetabolites; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Deoxyglucose | 2017 |
In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoprevention; Delay | 2018 |
Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma.
Topics: Actins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Fibrob | 2018 |
Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression.
Topics: Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Eso | 2018 |
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.
Topics: Animals; Antineoplastic Agents; Carbon; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Citri | 2018 |
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Caveolin 1; Cell Line, Tumor; Cocu | 2019 |
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur | 2019 |
Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma.
Topics: AC133 Antigen; Aged; Axin Protein; Carcinoma, Squamous Cell; Cell Proliferation; Female; Gene Expres | 2019 |
Glycolysis-related gene induction and ATP reduction during fractionated irradiation. Markers for radiation responsiveness of human tumor xenografts.
Topics: Adenosine Triphosphate; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose | 2013 |
Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer.
Topics: Aged; Carcinoma, Squamous Cell; Circadian Rhythm; Diet, Ketogenic; Female; Glucose; Head and Neck Ne | 2013 |
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal | 2014 |
Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Lactic Acid; Mice; Mice, Hairless; Nanoparti | 2015 |
13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.
Topics: Animals; Carbon Isotopes; Carcinoma, Squamous Cell; Colonic Neoplasms; HT29 Cells; Humans; Lactic Ac | 2015 |
Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Body Weight; Carcinoma, Squamous Cell; Cell Line, Tum | 2015 |
Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model.
Topics: Animals; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Line, Tu | 2015 |
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno | 2016 |
A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dr | 2015 |
MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1.
Topics: Carcinoma, Squamous Cell; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelia | 2016 |
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe | 2016 |
Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Epithelial Cells; Female; Humans; Isoenzymes; L-Lactate Dehyd | 2016 |
Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neopla | 2016 |
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug | 2016 |
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti | 2017 |
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2017 |
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam | 2016 |
Metabolic interrogation as a tool to optimize chemotherapeutic regimens.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug | 2017 |
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec | 2008 |
Short-echo spectroscopic imaging combined with lactate editing in a single scan.
Topics: Animals; Carcinoma, Squamous Cell; Complex Mixtures; Feasibility Studies; Humans; Lactic Acid; Lipid | 2008 |
Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Combined Modality Therapy; Drug Comp | 2010 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluo | 2009 |
Glycolytic metabolism and tumour response to fractionated irradiation.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose Fractionation, Rad | 2010 |
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcin | 2011 |
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiati | 2010 |
Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Contrast Media; Doxorubicin; Drug Carriers; Fem | 2010 |
Endoscopic submucosal dissection combined with the placement of biodegradable stents for recurrent esophageal cancer after chemoradiotherapy.
Topics: Absorbable Implants; Carcinoma, Squamous Cell; Chemoradiotherapy; Esophageal Neoplasms; Esophageal S | 2012 |
A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.
Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Squamous Cell; Cell Growth Processes; Dietary Carboh | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol | 2011 |
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N | 2012 |
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen | 2002 |
[Preparation of cucurbitacinBE polylactic acid nano-particles for targeting cervical lymph nodes].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; | 2001 |
[Excision of a cervical metastasis of an undiscovered spinocellular malpighian epithelioma: absence of recurrence 12 years later, failure to lactate the primary lesion].
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Lactic Acid; Neoplasm Recurrence, Local; | 1955 |
[The study of cucurbitacin BE polylactic acid nanoparticles delivering cucurbitacin BE to metastasized cervical lymph nodes in mice with oral cancer].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cucurbitacins; Delayed-Action | 2003 |
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
Topics: Carcinoma, Squamous Cell; Choline; Creatine; Female; Head and Neck Neoplasms; Humans; Lactic Acid; L | 2005 |
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Fe | 2006 |
Intratumoral delivery of paclitaxel-loaded poly(lactic-co-glycolic acid) microspheres for Hep-2 laryngeal squamous cell carcinoma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Capillaries; Carcinoma, Squamou | 2007 |
Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection.
Topics: Absorbable Implants; Carcinoma, Squamous Cell; Digestive System Surgical Procedures; Dissection; End | 2008 |
In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck N | 2008 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter | 1998 |
Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction.
Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Count; Fluorodeoxyglucose F18; Head and Neck Neoplasms; H | 2000 |
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits.
Topics: Animals; Arteries; Brachytherapy; Carcinoma, Squamous Cell; Ear, External; Embolization, Therapeutic | 2001 |