lactic acid has been researched along with Carcinoma, Epidermoid in 60 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 5.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| "Nude mice bearing FaDu, UT-SCC-15, and UT-SCC-5 hSCC were injected with pimonidazole hypoxia and Hoechst perfusion markers." | 3.75 | Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. ( Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D, 2009) |
| " We report here the results of the implantation of a novel biodegradable poly-L-lactic acid (PLLA) esophageal stent in two patients with benign esophageal stenosis after endoscopic submucosal dissection (ESD)." | 3.74 | Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection. ( Andoh, A; Fujiyama, Y; Hata, K; Minematsu, H; Murata, K; Nitta, N; Saito, Y; Tanaka, T; Tsujikawa, T, 2008) |
| "Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive." | 1.91 | F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023) |
| "Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis." | 1.91 | Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023) |
| "The migration and invasion of oral squamous cell carcinoma (OSCC) were promoted after being cocultured with the activated fibroblasts." | 1.51 | Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma. ( Chen, Y; Huang, C; Jiang, E; Liu, K; Liu, Q; Shang, Z; Shao, Z; Wang, H; Wang, L; Wang, M; Xu, Z; Yan, T; Zhou, X, 2019) |
| "Previous studies have shown that cervical cancer cells display markers of aerobic glycolysis, indicating that these tumors are likely to secrete lactate." | 1.51 | Lactate secreted by cervical cancer cells modulates macrophage phenotype. ( Alvarez, KLF; Baracat, EC; Boccardo, E; Carvalho, JP; Lepique, AP; Lorenzi, NP; Margarido, PFR; Rossetti, RAM; Stone, SC; Tacla, M; Yokochi, K, 2019) |
| "Oral squamous cell carcinoma (HSC-2, HSC-3) and normal (HaCaT) cells were used." | 1.46 | Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH. ( Kitamura, J; Morishima, H; Shinohara, Y; Takahashi, N; Takahashi, T; Washio, J, 2017) |
| "Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis." | 1.46 | Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017) |
| "Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up." | 1.43 | Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016) |
| "The two main histological variants, squamous cell carcinomas (SCC) and adenocarcinomas (AC), resemble the cell morphology of exocervix and endocervix, respectively." | 1.43 | STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment. ( Dias, S; Domingues, G; Felix, A; Ferreira, J; Goncalves, LG; Lam, EW; Maximo, V; Serpa, J; Silva, F; Silva, LS, 2016) |
| "Oral squamous cell carcinoma (OSCC) is the sixth most common human malignancy." | 1.43 | Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype. ( Dhupar, A; Saluja, TS; Spadigam, A; Syed, S, 2016) |
| "Herein, we analyzed biopsies of primary squamous cell carcinoma after surgery and adjuvant irradiation in 17 patients." | 1.43 | Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years. ( Blatt, S; Mueller-Klieser, W; Pabst, AM; Sagheb, K; Schroeder, T; Voelxen, N; Walenta, S; Ziebart, T, 2016) |
| "Oral squamous cell carcinoma (OSCC) or cancers of oral cavity is one of the most common cancers worldwide with high rate of mortality and morbidity." | 1.42 | A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy. ( Huo, ZJ; Li, XC; Liu, K; Liu, P; Pang, B; Wang, M; Wang, SJ; Wang, ZQ, 2015) |
| "In head and neck squamous cell carcinoma (HNSCC) aerobic glycolysis is the key feature for energy supply of the tumor." | 1.39 | Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. ( Himpe, B; Nitsch, S; Pries, R; Schroeder, U; Vonthein, R; Wollenberg, B, 2013) |
| "A high lactate content in malignant head and neck cancer (Head and neck squamous cell carcinomas, HNSCC) is associated with a higher risk of metastatic spread and lower overall patient survival." | 1.37 | Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue. ( Kunkel, M; Mueller-Klieser, W; Reichert, TE; Wagner, W; Walenta, S; Ziebart, T, 2011) |
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 1.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| "Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed." | 1.33 | Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. ( Bezabeh, T; Kerr, P; Nason, R; Odlum, O; Patel, R; Smith, IC; Sutherland, D, 2005) |
| "Five human head and neck squamous cell carcinoma cell lines (HNSCCs) xenografted in nude mice were treated with a clinically relevant irradiation protocol with 30 fractions within 6 weeks." | 1.33 | Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. ( Baumann, M; Mueller-Klieser, W; Quennet, V; Rosner, A; Walenta, S; Yaromina, A; Zips, D, 2006) |
| "A total of 22 NZW rabbits with VX2 squamous cell carcinomas transplanted into the auricles were intra-arterially (i." | 1.31 | Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits. ( Dullens, HF; Koole, R; Nijsen, JF; Slootweg, PJ; van Es, RJ; van het Schip, AD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.67) | 18.7374 |
| 1990's | 2 (3.33) | 18.2507 |
| 2000's | 17 (28.33) | 29.6817 |
| 2010's | 37 (61.67) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakashima, C | 1 |
| Fujiwara-Tani, R | 1 |
| Mori, S | 1 |
| Kishi, S | 1 |
| Ohmori, H | 1 |
| Fujii, K | 1 |
| Mori, T | 1 |
| Miyagawa, Y | 1 |
| Yamamoto, K | 1 |
| Kirita, T | 1 |
| Luo, Y | 1 |
| Kuniyasu, H | 1 |
| Sun, J | 1 |
| Tang, Q | 1 |
| Yu, S | 1 |
| Xie, M | 2 |
| Zheng, W | 1 |
| Chen, G | 2 |
| Yin, Y | 1 |
| Huang, X | 1 |
| Wo, K | 1 |
| Lei, H | 1 |
| Zhang, J | 2 |
| Wan, Q | 1 |
| Chen, L | 1 |
| Lin, Y | 1 |
| Qi, Y | 1 |
| Jiang, M | 1 |
| Huang, W | 1 |
| Li, B | 1 |
| Ohashi, T | 1 |
| Aoki, M | 1 |
| Tomita, H | 1 |
| Akazawa, T | 1 |
| Sato, K | 1 |
| Kuze, B | 1 |
| Mizuta, K | 1 |
| Hara, A | 1 |
| Nagaoka, H | 1 |
| Inoue, N | 1 |
| Ito, Y | 1 |
| Morishima, H | 1 |
| Washio, J | 1 |
| Kitamura, J | 1 |
| Shinohara, Y | 1 |
| Takahashi, T | 1 |
| Takahashi, N | 1 |
| Nieto, K | 1 |
| Pei, P | 1 |
| Wang, D | 1 |
| Mallery, SR | 1 |
| Schwendeman, SP | 1 |
| Wu, J | 1 |
| Hong, Y | 1 |
| Wu, T | 1 |
| Wang, J | 1 |
| Chen, X | 1 |
| Wang, Z | 1 |
| Cheng, B | 1 |
| Xia, J | 1 |
| Mao, X | 1 |
| Zhu, H | 2 |
| Luo, D | 1 |
| Ye, L | 1 |
| Yin, H | 1 |
| Zhang, Y | 2 |
| Yu, W | 1 |
| Chen, Y | 4 |
| Dubrulle, J | 1 |
| Stossi, F | 1 |
| Putluri, V | 1 |
| Sreekumar, A | 1 |
| Putluri, N | 1 |
| Baluya, D | 1 |
| Lai, SY | 3 |
| Sandulache, VC | 4 |
| Jiang, E | 1 |
| Xu, Z | 1 |
| Wang, M | 2 |
| Yan, T | 1 |
| Huang, C | 1 |
| Zhou, X | 1 |
| Liu, Q | 1 |
| Wang, L | 1 |
| Wang, H | 2 |
| Liu, K | 2 |
| Shao, Z | 1 |
| Shang, Z | 1 |
| Stone, SC | 1 |
| Rossetti, RAM | 1 |
| Alvarez, KLF | 1 |
| Carvalho, JP | 1 |
| Margarido, PFR | 1 |
| Baracat, EC | 1 |
| Tacla, M | 1 |
| Boccardo, E | 1 |
| Yokochi, K | 1 |
| Lorenzi, NP | 1 |
| Lepique, AP | 1 |
| Zhao, H | 1 |
| Hu, CY | 1 |
| Chen, WM | 1 |
| Huang, P | 1 |
| Goetze, K | 1 |
| Meyer, SS | 2 |
| Yaromina, A | 5 |
| Zips, D | 5 |
| Baumann, M | 5 |
| Mueller-Klieser, W | 8 |
| Schroeder, U | 1 |
| Himpe, B | 1 |
| Pries, R | 1 |
| Vonthein, R | 1 |
| Nitsch, S | 1 |
| Wollenberg, B | 1 |
| Clatot, F | 1 |
| Gouérant, S | 1 |
| Mareschal, S | 1 |
| Cornic, M | 1 |
| Berghian, A | 1 |
| Choussy, O | 1 |
| El Ouakif, F | 1 |
| François, A | 1 |
| Bénard, M | 1 |
| Ruminy, P | 1 |
| Picquenot, JM | 1 |
| Jardin, F | 1 |
| Wang, X | 2 |
| Shi, L | 1 |
| Tu, Q | 1 |
| Zhang, H | 2 |
| Wang, P | 1 |
| Zhang, L | 1 |
| Huang, Z | 1 |
| Zhao, F | 1 |
| Luan, H | 1 |
| Saito, K | 2 |
| Matsumoto, S | 1 |
| Takakusagi, Y | 1 |
| Matsuo, M | 1 |
| Morris, HD | 1 |
| Lizak, MJ | 1 |
| Munasinghe, JP | 1 |
| Devasahayam, N | 1 |
| Subramanian, S | 1 |
| Mitchell, JB | 1 |
| Krishna, MC | 2 |
| Pradhan, R | 1 |
| Ramasamy, T | 1 |
| Choi, JY | 1 |
| Kim, JH | 1 |
| Poudel, BK | 1 |
| Tak, JW | 1 |
| Nukolova, N | 1 |
| Choi, HG | 1 |
| Yong, CS | 1 |
| Kim, JO | 1 |
| Skinner, HD | 2 |
| Lu, T | 1 |
| Feng, L | 3 |
| Court, LE | 1 |
| Myers, JN | 3 |
| Meyn, RE | 2 |
| Fuller, CD | 2 |
| Bankson, JA | 2 |
| Grimm, M | 1 |
| Krimmel, M | 1 |
| Hoefert, S | 1 |
| Kraut, W | 1 |
| Calgéer, B | 1 |
| Biegner, T | 1 |
| Teriete, P | 1 |
| Munz, A | 1 |
| Reinert, S | 1 |
| Vlachostergios, PJ | 1 |
| Oikonomou, KG | 1 |
| Gibilaro, E | 1 |
| Apergis, G | 1 |
| Wang, ZQ | 1 |
| Huo, ZJ | 1 |
| Li, XC | 1 |
| Liu, P | 1 |
| Pang, B | 1 |
| Wang, SJ | 1 |
| Xu, P | 1 |
| Li, Y | 1 |
| Li, M | 1 |
| Silva, LS | 1 |
| Goncalves, LG | 1 |
| Silva, F | 1 |
| Domingues, G | 1 |
| Maximo, V | 1 |
| Ferreira, J | 1 |
| Lam, EW | 1 |
| Dias, S | 1 |
| Felix, A | 1 |
| Serpa, J | 1 |
| Saluja, TS | 1 |
| Spadigam, A | 1 |
| Dhupar, A | 1 |
| Syed, S | 1 |
| Blatt, S | 1 |
| Voelxen, N | 1 |
| Sagheb, K | 1 |
| Pabst, AM | 1 |
| Walenta, S | 7 |
| Schroeder, T | 3 |
| Ziebart, T | 2 |
| Masloub, SM | 1 |
| Elmalahy, MH | 1 |
| Sabry, D | 1 |
| Mohamed, WS | 1 |
| Ahmed, SH | 1 |
| Xu, Q | 1 |
| Zhang, Q | 1 |
| Ishida, Y | 1 |
| Hajjar, S | 1 |
| Tang, X | 1 |
| Shi, H | 1 |
| Dang, CV | 1 |
| Le, AD | 1 |
| Li, HM | 1 |
| Yang, JG | 1 |
| Liu, ZJ | 1 |
| Wang, WM | 1 |
| Yu, ZL | 1 |
| Ren, JG | 1 |
| Zhang, W | 1 |
| Jia, J | 1 |
| Neveu, MA | 1 |
| De Preter, G | 1 |
| Joudiou, N | 1 |
| Bol, A | 1 |
| Brender, JR | 1 |
| Kishimoto, S | 1 |
| Grégoire, V | 1 |
| Jordan, BF | 1 |
| Feron, O | 1 |
| Gallez, B | 1 |
| William, WN | 1 |
| Li, J | 1 |
| Mijiti, A | 1 |
| Konopleva, MY | 1 |
| Wigfield, SM | 1 |
| Winter, SC | 1 |
| Giatromanolaki, A | 1 |
| Taylor, J | 1 |
| Koukourakis, ML | 1 |
| Harris, AL | 1 |
| Melkus, G | 2 |
| Mörchel, P | 2 |
| Behr, VC | 1 |
| Kotas, M | 1 |
| Flentje, M | 2 |
| Jakob, PM | 2 |
| Ping, Y | 1 |
| Jian, Z | 1 |
| Yi, Z | 1 |
| Huoyu, Z | 1 |
| Yuqiong, Y | 1 |
| Shixi, L | 1 |
| Quennet, V | 3 |
| Meyer, S | 1 |
| Shakirin, G | 1 |
| Sattler, UG | 1 |
| Hoerner, C | 1 |
| Knoerzer, H | 1 |
| Fabian, C | 1 |
| Kunkel, M | 1 |
| Reichert, TE | 1 |
| Wagner, W | 1 |
| Lee, SM | 1 |
| Park, H | 1 |
| Yoo, KH | 1 |
| Mochizuki, Y | 1 |
| Saito, Y | 2 |
| Tanaka, T | 2 |
| Nitta, N | 2 |
| Yamada, H | 1 |
| Tsujikawa, T | 2 |
| Murata, K | 2 |
| Fujiyama, Y | 2 |
| Andoh, A | 2 |
| Ho, VW | 1 |
| Leung, K | 1 |
| Hsu, A | 1 |
| Luk, B | 1 |
| Lai, J | 1 |
| Shen, SY | 1 |
| Minchinton, AI | 1 |
| Waterhouse, D | 1 |
| Bally, MB | 1 |
| Lin, W | 1 |
| Nelson, BH | 1 |
| Sly, LM | 1 |
| Krystal, G | 1 |
| Ow, TJ | 1 |
| Pickering, CR | 1 |
| Frederick, MJ | 1 |
| Zhou, G | 1 |
| Fokt, I | 1 |
| Davis-Malesevich, M | 1 |
| Priebe, W | 1 |
| Kowalski, W | 1 |
| Nocon, D | 1 |
| Gamian, A | 1 |
| Kołodziej, J | 1 |
| Rakus, D | 1 |
| Yang, K | 3 |
| Wen, Y | 3 |
| Li, L | 1 |
| Wang, C | 3 |
| Hou, S | 1 |
| Li, C | 1 |
| MOIROUD, P | 1 |
| BONNEAU, H | 1 |
| Bezabeh, T | 1 |
| Odlum, O | 1 |
| Nason, R | 1 |
| Kerr, P | 1 |
| Sutherland, D | 1 |
| Patel, R | 1 |
| Smith, IC | 1 |
| Rosner, A | 1 |
| Zhou, L | 1 |
| Hu, T | 1 |
| Yao, M | 1 |
| Minematsu, H | 1 |
| Hata, K | 1 |
| Le, QT | 1 |
| Koong, A | 1 |
| Lieskovsky, YY | 1 |
| Narasimhan, B | 1 |
| Graves, E | 1 |
| Pinto, H | 1 |
| Brown, JM | 2 |
| Spielman, D | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 2 |
| Egilmez, NK | 1 |
| Jong, YS | 1 |
| Iwanuma, Y | 1 |
| Jacob, JS | 1 |
| Santos, CA | 1 |
| Chen, FA | 1 |
| Mathiowitz, E | 1 |
| Bankert, RB | 1 |
| Star-Lack, JM | 1 |
| Adalsteinsson, E | 1 |
| Adam, MF | 1 |
| Terris, DJ | 1 |
| Pinto, HA | 1 |
| Spielman, DM | 1 |
| Smith, TA | 1 |
| Titley, J | 1 |
| Dwarkanath, BS | 1 |
| Zolzer, F | 1 |
| Chandana, S | 1 |
| Bauch, T | 1 |
| Adhikari, JS | 1 |
| Muller, WU | 1 |
| Jain, V | 1 |
| Brizel, DM | 1 |
| Scher, RL | 1 |
| Clough, RW | 1 |
| Dewhirst, MW | 1 |
| van Es, RJ | 1 |
| Nijsen, JF | 1 |
| van het Schip, AD | 1 |
| Dullens, HF | 1 |
| Slootweg, PJ | 1 |
| Koole, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer[NCT00140556] | Early Phase 1 | 28 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue[NCT02975739] | 1 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Slow accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response (resolution) of tumor on clinical exam. (NCT00140556)
Timeframe: Within 30 days of completing RT
| Intervention | Participants (Number) |
|---|---|
| Entire Study Population | 25 |
3 trials available for lactic acid and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Elevated lactic acid is a negative prognostic factor in metastatic lung cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Sm | 2015 |
[Clinical application of anticancer nanoparticles targeting metastasis foci of cervical lymph nodes in patients with oral carcinoma].
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Chromatography, High Press | 2003 |
In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Choline; Creatine; Head and Neck Neoplasms; Humans; Lactic Ac | 2000 |
57 other studies available for lactic acid and Carcinoma, Epidermoid
| Article | Year |
|---|---|
An Axis between the Long Non-Coding RNA
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Flavin-Adenine Dinucleotide | 2022 |
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop | 2023 |
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas | 2023 |
M2-like macrophage polarization in high lactic acid-producing head and neck cancer.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Squamous Cell | 2017 |
Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.
Topics: Acids; Ammonia; Antimetabolites; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Deoxyglucose | 2017 |
In vivo controlled release of fenretinide from long-acting release depots for chemoprevention of oral squamous cell carcinoma recurrence.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Chemoprevention; Delay | 2018 |
Stromal-epithelial lactate shuttle induced by tumor‑derived interleukin‑1β promotes cell proliferation in oral squamous cell carcinoma.
Topics: Actins; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Fibrob | 2018 |
Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression.
Topics: Capsaicin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Eso | 2018 |
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.
Topics: Animals; Antineoplastic Agents; Carbon; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Citri | 2018 |
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Topics: Animals; Cancer-Associated Fibroblasts; Carcinoma, Squamous Cell; Caveolin 1; Cell Line, Tumor; Cocu | 2019 |
Lactate secreted by cervical cancer cells modulates macrophage phenotype.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Line, Tumor; Cocultur | 2019 |
Lactate Promotes Cancer Stem-like Property of Oral Sequamous Cell Carcinoma.
Topics: AC133 Antigen; Aged; Axin Protein; Carcinoma, Squamous Cell; Cell Proliferation; Female; Gene Expres | 2019 |
Glycolysis-related gene induction and ATP reduction during fractionated irradiation. Markers for radiation responsiveness of human tumor xenografts.
Topics: Adenosine Triphosphate; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose | 2013 |
Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer.
Topics: Aged; Carcinoma, Squamous Cell; Circadian Rhythm; Diet, Ketogenic; Female; Glucose; Head and Neck Ne | 2013 |
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal | 2014 |
Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Lactic Acid; Mice; Mice, Hairless; Nanoparti | 2015 |
13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.
Topics: Animals; Carbon Isotopes; Carcinoma, Squamous Cell; Colonic Neoplasms; HT29 Cells; Humans; Lactic Ac | 2015 |
Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin.
Topics: Animals; Antineoplastic Agents; Benzoquinones; Body Weight; Carcinoma, Squamous Cell; Cell Line, Tum | 2015 |
Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model.
Topics: Animals; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Line, Tu | 2015 |
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno | 2016 |
A cell-targeted chemotherapeutic nanomedicine strategy for oral squamous cell carcinoma therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dr | 2015 |
MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1.
Topics: Carcinoma, Squamous Cell; Cell Count; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epithelia | 2016 |
STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cervix Uteri; Female; Forkhe | 2016 |
Equating salivary lactate dehydrogenase (LDH) with LDH-5 expression in patients with oral squamous cell carcinoma: An insight into metabolic reprogramming of cancer cell as a predictor of aggressive phenotype.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Epithelial Cells; Female; Humans; Isoenzymes; L-Lactate Dehyd | 2016 |
Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neopla | 2016 |
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug | 2016 |
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti | 2017 |
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2017 |
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam | 2016 |
Metabolic interrogation as a tool to optimize chemotherapeutic regimens.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug | 2017 |
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec | 2008 |
Short-echo spectroscopic imaging combined with lactate editing in a single scan.
Topics: Animals; Carcinoma, Squamous Cell; Complex Mixtures; Feasibility Studies; Humans; Lactic Acid; Lipid | 2008 |
Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Combined Modality Therapy; Drug Comp | 2010 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluo | 2009 |
Glycolytic metabolism and tumour response to fractionated irradiation.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose Fractionation, Rad | 2010 |
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcin | 2011 |
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiati | 2010 |
Synergistic cancer therapeutic effects of locally delivered drug and heat using multifunctional nanoparticles.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Contrast Media; Doxorubicin; Drug Carriers; Fem | 2010 |
Endoscopic submucosal dissection combined with the placement of biodegradable stents for recurrent esophageal cancer after chemoradiotherapy.
Topics: Absorbable Implants; Carcinoma, Squamous Cell; Chemoradiotherapy; Esophageal Neoplasms; Esophageal S | 2012 |
A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.
Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Squamous Cell; Cell Growth Processes; Dietary Carboh | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol | 2011 |
Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, N | 2012 |
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen | 2002 |
[Preparation of cucurbitacinBE polylactic acid nano-particles for targeting cervical lymph nodes].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; | 2001 |
[Excision of a cervical metastasis of an undiscovered spinocellular malpighian epithelioma: absence of recurrence 12 years later, failure to lactate the primary lesion].
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Lactic Acid; Neoplasm Recurrence, Local; | 1955 |
[The study of cucurbitacin BE polylactic acid nanoparticles delivering cucurbitacin BE to metastasized cervical lymph nodes in mice with oral cancer].
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Squamous Cell; Cucurbitacins; Delayed-Action | 2003 |
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
Topics: Carcinoma, Squamous Cell; Choline; Creatine; Female; Head and Neck Neoplasms; Humans; Lactic Acid; L | 2005 |
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Fe | 2006 |
Intratumoral delivery of paclitaxel-loaded poly(lactic-co-glycolic acid) microspheres for Hep-2 laryngeal squamous cell carcinoma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Capillaries; Carcinoma, Squamou | 2007 |
Novel biodegradable stents for benign esophageal strictures following endoscopic submucosal dissection.
Topics: Absorbable Implants; Carcinoma, Squamous Cell; Digestive System Surgical Procedures; Dissection; End | 2008 |
In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck N | 2008 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
Topics: Animals; Carcinoma, Squamous Cell; Delayed-Action Preparations; Drug Delivery Systems; Humans; Inter | 1998 |
Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction.
Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Count; Fluorodeoxyglucose F18; Head and Neck Neoplasms; H | 2000 |
Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Carcinoma, Squamous Cell; Deoxyglucose; DNA Damage; D | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits.
Topics: Animals; Arteries; Brachytherapy; Carcinoma, Squamous Cell; Ear, External; Embolization, Therapeutic | 2001 |