lactic acid has been researched along with Carcinogenesis in 41 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 8.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 7.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 5.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 4.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| " In order to enhance the biological activity of α-mangostin, we formulated mangostin-encapsulated PLGA nanoparticles (Mang-NPs) and examined the molecular mechanisms by which they inhibit human and KC mice (Pdx(Cre);LSL-Kras(G12D)) pancreatic CSC characteristics in vitro, and pancreatic carcinogenesis in KPC (Pdx(Cre);LSLKras(G12D);LSL-Trp53(R172H)) mice." | 3.83 | α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. ( Shankar, S; Shrivastava, A; Srivastava, RK; Verma, RK; Yu, W, 2016) |
| "We hypothesize that lactagenesis for carcinogenesis is the explanation and purpose of the Warburg Effect." | 2.55 | Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect. ( Brooks, GA; San-Millán, I, 2017) |
| "Cutaneous melanoma is an aggressive and deadly cancer resulting from malignant transformation of cells involved in skin pigmentation." | 1.91 | Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth. ( Chen, C; Zhang, X, 2023) |
| "PITX2 has been earlier shown to induce ovarian cancer cell proliferation through the activation of different signaling cascades." | 1.91 | Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation. ( Bandopadhyay, S; Chakrabarti, S; Ghosh, DD; Kamal, IM; Padmanaban, E; Roy, SS, 2023) |
| "However, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear." | 1.91 | A novel tyrosine tRNA-derived fragment, tRF ( Cao, J; Chen, X; Guo, Y; Li, W; Liu, M; Liu, Y; Sun, Y; Tian, L; Wang, J; Xu, L; Yang, Z; Zhang, J; Zhao, B; Zhao, R, 2023) |
| "Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive." | 1.91 | A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch. ( Ahmad, M; Chen, C; He, Q; Hu, Y; Li, J; Lin, Y; Luo, H; Luo, Y; Sun, Y; Wang, B; Wu, D; Yang, Z; Zheng, L, 2023) |
| "Given its roles in oncogenesis, measuring intratumoural and systemic lactate levels has shown promise as a both predictive and prognostic biomarker in several cancer types." | 1.62 | The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment. ( Davern, M; Donlon, NE; Donohoe, CL; Hayes, C, 2021) |
| "However, the function of SETD1A in gastric cancer (GC) progression and its role in GC metabolic reprogramming are still largely unknown." | 1.56 | Histone methyltransferase SETD1A interacts with HIF1α to enhance glycolysis and promote cancer progression in gastric cancer. ( Chai, H; Gu, Y; Wu, J; Xu, X; Yu, J, 2020) |
| "Chronic inflammation is a major driving factor for the development of colitis-associated cancer (CAC)." | 1.51 | ( Cao, G; Li, J; Li, Z; Shen, H; Xie, P; Yue, Z; Zang, T; Zhang, S; Zhu, Y, 2019) |
| "Furthermore, LDHA/PDHA1 changes in HNSCC cells resulted in a broad metabolic reprogramming while intracellular molecules including polyunsaturated fatty acids and nitrogen metabolism related metabolites underlie the malignant changes." | 1.51 | Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. ( Chang, CW; Chen, HM; Chen, TY; Chen, YF; Chia, HY; Chou, CY; Chuang, LT; Hsieh, YT; Huang, JM; Huang, PC; Kuo, TY; Li, WC; Liu, CJ; Lo, JF, 2019) |
| "Urethane is a recognized genotoxic carcinogen in fermented foods and beverages." | 1.43 | Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. ( Cao, N; Deng, J; Du, G; Duan, Y; Geng, S; Guo, Z; Lin, H; Ma, X; Meng, M; Zheng, Y, 2016) |
| "In addition, miR-203 promoted the metastasis of ovarian cancer cells in vivo and shorted the survival of the nude mice." | 1.43 | MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway. ( Kejian, Z; Lichun, F; Na, X; Shaosheng, W; Xiaohong, Z; Xiaolan, X, 2016) |
| "In addition, we established a colorectal cancer model, and detected CD147 expression in vivo." | 1.39 | Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo. ( Deng, Q; Gao, T; He, B; Li, R; Pan, Y; Song, G; Sun, H; Wang, S; Xu, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 20 (48.78) | 24.3611 |
| 2020's | 21 (51.22) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, B | 1 |
| Pomicter, AD | 1 |
| Li, F | 1 |
| Bhatt, S | 1 |
| Chen, C | 3 |
| Li, W | 3 |
| Qi, M | 1 |
| Huang, C | 1 |
| Deininger, MW | 1 |
| Kong, MG | 1 |
| Chen, HL | 1 |
| Zhao, JL | 1 |
| Ye, YC | 1 |
| Gao, CC | 1 |
| Wang, L | 1 |
| Ren, KX | 1 |
| Jiang, R | 1 |
| Hu, SJ | 1 |
| Liang, SQ | 1 |
| Bai, J | 1 |
| Liang, JL | 1 |
| Ma, PF | 1 |
| Hu, YY | 1 |
| Li, BC | 1 |
| Nie, YZ | 1 |
| Chen, Y | 1 |
| Li, XF | 1 |
| Zhang, W | 2 |
| Han, H | 1 |
| Qin, HY | 1 |
| Pan, L | 1 |
| Feng, F | 1 |
| Wu, J | 5 |
| Fan, S | 1 |
| Han, J | 1 |
| Wang, S | 2 |
| Yang, L | 1 |
| Liu, W | 1 |
| Wang, C | 1 |
| Xu, K | 1 |
| Markelova, NN | 1 |
| Semenova, EF | 1 |
| Sineva, ON | 1 |
| Sadykova, VS | 1 |
| Lv, X | 1 |
| Lv, Y | 1 |
| Dai, X | 1 |
| Brooks, GA | 2 |
| Osmond, AD | 1 |
| Arevalo, JA | 1 |
| Duong, JJ | 1 |
| Curl, CC | 1 |
| Moreno-Santillan, DD | 1 |
| Leija, RG | 1 |
| Gao, X | 1 |
| Zhou, S | 1 |
| Qin, Z | 1 |
| Li, D | 1 |
| Zhu, Y | 3 |
| Ma, D | 1 |
| Sun, Q | 1 |
| Zhu, G | 1 |
| Li, T | 1 |
| Zhu, X | 1 |
| Ni, B | 1 |
| Xu, B | 1 |
| Ma, X | 2 |
| Li, J | 4 |
| Zhang, X | 1 |
| Chen, Z | 1 |
| He, Q | 2 |
| Lu, T | 1 |
| Shi, G | 1 |
| He, L | 1 |
| Zong, H | 1 |
| Liu, B | 1 |
| Zhu, P | 1 |
| Bandopadhyay, S | 1 |
| Kamal, IM | 1 |
| Padmanaban, E | 1 |
| Ghosh, DD | 1 |
| Chakrabarti, S | 1 |
| Roy, SS | 1 |
| Wang, T | 2 |
| Ye, Z | 1 |
| Li, Z | 2 |
| Jing, DS | 1 |
| Fan, GX | 1 |
| Liu, MQ | 1 |
| Zhuo, QF | 1 |
| Ji, SR | 1 |
| Yu, XJ | 1 |
| Xu, XW | 1 |
| Qin, Y | 1 |
| Zhao, R | 1 |
| Yang, Z | 2 |
| Zhao, B | 1 |
| Liu, Y | 1 |
| Chen, X | 1 |
| Cao, J | 1 |
| Zhang, J | 1 |
| Guo, Y | 2 |
| Xu, L | 2 |
| Wang, J | 1 |
| Sun, Y | 2 |
| Liu, M | 1 |
| Tian, L | 1 |
| Ahmad, M | 1 |
| Lin, Y | 1 |
| Wu, D | 1 |
| Zheng, L | 1 |
| Wang, B | 1 |
| Hu, Y | 1 |
| Luo, H | 1 |
| Luo, Y | 1 |
| Chen, L | 2 |
| Qi, H | 1 |
| Shi, X | 1 |
| Zhong, M | 1 |
| Chen, H | 1 |
| Li, Q | 1 |
| Chai, H | 1 |
| Xu, X | 1 |
| Yu, J | 1 |
| Gu, Y | 1 |
| Sharma, NK | 1 |
| Pal, JK | 1 |
| Ferreira-Lazarte, A | 1 |
| Fernández, J | 1 |
| Gallego-Lobillo, P | 1 |
| Villar, CJ | 1 |
| Lombó, F | 1 |
| Moreno, FJ | 1 |
| Villamiel, M | 1 |
| Hayes, C | 1 |
| Donohoe, CL | 1 |
| Davern, M | 1 |
| Donlon, NE | 1 |
| Jiang, X | 1 |
| Yuan, J | 2 |
| Dou, Y | 1 |
| Zeng, D | 1 |
| Xiao, S | 1 |
| Keibler, MA | 1 |
| Dong, W | 1 |
| Korthauer, KD | 1 |
| Hosios, AM | 1 |
| Moon, SJ | 1 |
| Sullivan, LB | 1 |
| Liu, N | 1 |
| Abbott, KL | 1 |
| Arevalo, OD | 1 |
| Ho, K | 1 |
| Lee, J | 1 |
| Phanse, AS | 1 |
| Kelleher, JK | 1 |
| Iliopoulos, O | 1 |
| Coloff, JL | 1 |
| Vander Heiden, MG | 2 |
| Stephanopoulos, G | 1 |
| Zhang, S | 1 |
| Xie, P | 1 |
| Zang, T | 1 |
| Shen, H | 1 |
| Cao, G | 1 |
| Yue, Z | 1 |
| Romero-Cordoba, SL | 1 |
| Rodriguez-Cuevas, S | 1 |
| Bautista-Pina, V | 1 |
| Maffuz-Aziz, A | 1 |
| D'Ippolito, E | 1 |
| Cosentino, G | 1 |
| Baroni, S | 1 |
| Iorio, MV | 1 |
| Hidalgo-Miranda, A | 1 |
| Li, L | 2 |
| Chen, T | 1 |
| Zhao, L | 1 |
| Wang, H | 1 |
| Wang, X | 2 |
| Liu, X | 1 |
| Wang, D | 1 |
| Li, B | 1 |
| Mak, TW | 1 |
| Du, W | 1 |
| Yang, X | 1 |
| Jiang, P | 1 |
| Updegraff, BL | 1 |
| Zhou, X | 1 |
| Padanad, MS | 1 |
| Chen, PH | 1 |
| Yang, C | 1 |
| Sudderth, J | 1 |
| Rodriguez-Tirado, C | 1 |
| Girard, L | 1 |
| Minna, JD | 1 |
| Mishra, P | 1 |
| DeBerardinis, RJ | 1 |
| O'Donnell, KA | 1 |
| Schwörer, S | 1 |
| Vardhana, SA | 1 |
| Thompson, CB | 1 |
| da Veiga Moreira, J | 1 |
| Hamraz, M | 1 |
| Abolhassani, M | 1 |
| Schwartz, L | 1 |
| Jolicœur, M | 1 |
| Peres, S | 1 |
| Chen, TY | 1 |
| Hsieh, YT | 1 |
| Huang, JM | 1 |
| Liu, CJ | 1 |
| Chuang, LT | 1 |
| Huang, PC | 1 |
| Kuo, TY | 1 |
| Chia, HY | 1 |
| Chou, CY | 1 |
| Chang, CW | 1 |
| Chen, YF | 1 |
| Chen, HM | 1 |
| Lo, JF | 1 |
| Li, WC | 1 |
| Ullmann, P | 2 |
| Nurmik, M | 1 |
| Begaj, R | 1 |
| Haan, S | 2 |
| Letellier, E | 2 |
| Ni, FD | 1 |
| Hao, SL | 1 |
| Yang, WX | 1 |
| Martin, ES | 1 |
| Belmont, PJ | 1 |
| Sinnamon, MJ | 1 |
| Richard, LG | 1 |
| Coffee, EM | 1 |
| Roper, J | 1 |
| Lee, L | 1 |
| Heidari, P | 1 |
| Lunt, SY | 1 |
| Goel, G | 1 |
| Ji, X | 1 |
| Xie, Z | 1 |
| Xie, T | 1 |
| Lamb, J | 1 |
| Weinrich, SL | 1 |
| VanArsdale, T | 1 |
| Bronson, RT | 1 |
| Xavier, RJ | 1 |
| Kan, JL | 1 |
| Mahmood, U | 1 |
| Hung, KE | 1 |
| Li, R | 1 |
| Pan, Y | 1 |
| He, B | 1 |
| Xu, Y | 1 |
| Gao, T | 1 |
| Song, G | 1 |
| Sun, H | 1 |
| Deng, Q | 1 |
| Wang, Y | 1 |
| Li, G | 1 |
| Mao, F | 1 |
| Li, X | 1 |
| Liu, Q | 1 |
| Lv, L | 1 |
| Dai, W | 1 |
| Wang, G | 1 |
| Zhao, E | 1 |
| Tang, KF | 1 |
| Sun, ZS | 1 |
| Bhatnagar, P | 1 |
| Pant, AB | 1 |
| Shukla, Y | 1 |
| Chaudhari, B | 1 |
| Kumar, P | 1 |
| Gupta, KC | 1 |
| Minton, DR | 1 |
| Fu, L | 1 |
| Chen, Q | 1 |
| Robinson, BD | 1 |
| Gross, SS | 1 |
| Nanus, DM | 1 |
| Gudas, LJ | 1 |
| Deng, J | 1 |
| Cao, N | 1 |
| Guo, Z | 1 |
| Zheng, Y | 1 |
| Geng, S | 1 |
| Meng, M | 1 |
| Lin, H | 1 |
| Duan, Y | 1 |
| Du, G | 1 |
| Del Carmen, S | 1 |
| de Moreno de LeBlanc, A | 1 |
| LeBlanc, JG | 1 |
| Qureshi-Baig, K | 1 |
| Rodriguez, F | 1 |
| Ginolhac, A | 1 |
| Nonnenmacher, Y | 1 |
| Ternes, D | 1 |
| Weiler, J | 1 |
| Gäbler, K | 1 |
| Bahlawane, C | 1 |
| Hiller, K | 1 |
| Verma, RK | 1 |
| Yu, W | 1 |
| Shrivastava, A | 1 |
| Shankar, S | 1 |
| Srivastava, RK | 1 |
| Xiaohong, Z | 1 |
| Lichun, F | 1 |
| Na, X | 1 |
| Kejian, Z | 1 |
| Xiaolan, X | 1 |
| Shaosheng, W | 1 |
| San-Millán, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Very Low Carbohydrate Diet to Glasgow Prognostic Score, Serum Lactate and TNF Alpha on Colorectal Cancer Patients With Best Supportive Care[NCT03221920] | 26 participants (Anticipated) | Interventional | 2017-08-05 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for lactic acid and Carcinogenesis
| Article | Year |
|---|---|
The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis.
Topics: Bacteria; Bacterial Toxins; Bile Acids and Salts; Butyrates; Carcinogenesis; Humans; Lactic Acid; Tu | 2022 |
Lactate, histone lactylation and cancer hallmarks.
Topics: Carcinogenesis; Epigenomics; Histones; Humans; Lactic Acid; Neoplasms | 2023 |
Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism.
Topics: Carcinogenesis; Exercise; Humans; Lactic Acid; Muscles; Oxidation-Reduction | 2023 |
Lactate-related metabolic reprogramming and immune regulation in colorectal cancer.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Colorectal Neoplasms; Glycolysis; Humans; Lactic Ac | 2022 |
Lactate-induced protein lactylation: A bridge between epigenetics and metabolic reprogramming in cancer.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Epigenesis, Genetic; Histones; Humans; Lactic Acid; | 2023 |
Cancer Metabolism Drives a Stromal Regenerative Response.
Topics: Amino Acids; Animals; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Glucose; Hu | 2019 |
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells.
Topics: Animals; Carcinogenesis; Cell Hypoxia; Disease Progression; Humans; Lactic Acid; MicroRNAs; Neoplast | 2019 |
Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis.
Topics: Adherens Junctions; Animals; Carcinogenesis; Humans; Infertility, Male; Lactic Acid; Male; Sertoli C | 2019 |
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect.
Topics: Carcinogenesis; Glycolysis; Humans; Lactic Acid; Mitochondria; Neoplasms; Neovascularization, Pathol | 2017 |
32 other studies available for lactic acid and Carcinogenesis
| Article | Year |
|---|---|
Trident cold atmospheric plasma blocks three cancer survival pathways to overcome therapy resistance.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Humans; Lactic Acid; Leukemia, Experimental; Leukemia, My | 2021 |
Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis.
Topics: Carcinogenesis; Humans; Lactic Acid; Myeloid Cells; Myeloid-Derived Suppressor Cells; Signal Transdu | 2022 |
Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Trans | 2022 |
Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colorecta | 2023 |
Glycolysis regulator PFKP induces human melanoma cell proliferation and tumor growth.
Topics: Adenosine Triphosphate; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Humans; La | 2023 |
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Topics: Carcinogenesis; Humans; Lactic Acid; Liver; Mitochondria; Oxidative Phosphorylation; Phosphoglycerat | 2023 |
Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Female; Gene Exp | 2023 |
A novel tyrosine tRNA-derived fragment, tRF
Topics: Carcinogenesis; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Lactate Deh | 2023 |
A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Glucosephosphate Dehydrogenase; Glutathione S-Trans | 2023 |
ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy.
Topics: Carcinogenesis; Down-Regulation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; L | 2023 |
Histone methyltransferase SETD1A interacts with HIF1α to enhance glycolysis and promote cancer progression in gastric cancer.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Disease Progression; Fermentation; Ge | 2020 |
Metabolic Ink Lactate Modulates Epigenomic Landscape: A Concerted Role of Pro-tumor Microenvironment and Macroenvironment During Carcinogenesis.
Topics: Carcinogenesis; Epigenomics; Humans; Lactic Acid; Neoplasms; Protein Processing, Post-Translational; | 2021 |
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model.
Topics: Acetates; Animals; Azoxymethane; Bifidobacterium; Blood Glucose; Body Weight; Butyrates; Carcinogene | 2021 |
The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment.
Topics: Antineoplastic Agents; Carcinogenesis; Glucose Transporter Type 1; Glycolysis; Hexokinase; Humans; I | 2021 |
Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical Cancer Cells Through the FRA1/MDM2/p53 Pathway.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cervix Uteri; Female; Gene Expression Regulati | 2021 |
Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epidermal Growth Factor; Epit | 2021 |
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Dextran Sulfate; Diet; Dis | 2019 |
Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression | 2018 |
TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Carcinogenesis; Cell Line, Tumor; Cell Proliferation | 2018 |
Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism.
Topics: Basigin; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Membrane; Cell Proliferation; | 2018 |
Metabolic therapies inhibit tumor growth in vivo and in silico.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbon; Carcinogenesis; Carcinoma, Lewis Lu | 2019 |
Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Heterografts; Humans; L-L | 2019 |
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Cluster Analysis; Colonic Neoplasms; Disease Models, Anim | 2013 |
Downregulation of CD147 expression by RNA interference inhibits HT29 cell proliferation, invasion and tumorigenicity in vitro and in vivo.
Topics: Antineoplastic Agents; Basigin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Col | 2013 |
Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.
Topics: Adult; Aged; Animals; Biological Transport; Carcinogenesis; Cell Line, Tumor; Cell Transformation, N | 2014 |
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Topics: Administration, Cutaneous; Ananas; Animals; Anticarcinogenic Agents; Bromelains; Carcinogenesis; Del | 2015 |
Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.
Topics: Aerobiosis; Animals; Carcinogenesis; Carcinoma, Renal Cell; Gene Expression Profiling; Gene Expressi | 2015 |
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.
Topics: Animals; Carcinogenesis; Carcinogens; Cell Line, Tumor; Deoxyglucose; Disease Models, Animal; Diseas | 2016 |
Development of a potential probiotic yoghurt using selected anti-inflammatory lactic acid bacteria for prevention of colitis and carcinogenesis in mice.
Topics: Animals; Carcinogenesis; Colitis; Colonic Neoplasms; Female; Fermentation; Humans; Intestines; Lacti | 2016 |
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production.
Topics: Aged; Aged, 80 and over; Carcinogenesis; Cell Self Renewal; Colon; Colonic Neoplasms; Colorectal Neo | 2016 |
α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice.
Topics: Animals; Antigens, CD; Apoptosis; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell S | 2016 |
MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway.
Topics: 3' Untranslated Regions; Animals; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferatio | 2016 |