lactic acid has been researched along with Cancer of Prostate in 105 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb." | 7.85 | Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017) |
| "This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb." | 3.85 | Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. ( Gdowski, AS; Ranjan, A; Sarker, MR; Vishwanatha, JK, 2017) |
| " Studies on the dosage design of this new delivery system of leuprorelin are summarized." | 2.38 | [Once-a-month injectable microcapsules of leuprorelin acetate]. ( Ogawa, Y; Okada, H; Toguchi, H; Yamamoto, M, 1991) |
| "NPAS2 is upregulated in prostate cancer and promotes cell survival by promoting glycolysis and inhibiting oxidative phosphorylation in PCa cells." | 1.91 | NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling. ( Chen, Y; Han, S; Jia, W; Ma, S; Qi, R; Qin, W; Quan, P; Wang, F; Wang, G; Yang, X; Yuan, J; Zhang, J; Zhang, X, 2023) |
| "Metastasis is the leading cause of mortalities in cancer patients due to the spreading of cancer cells to various organs." | 1.62 | Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods. ( Gao, X; Pu, Y; Smith, J; Wang, C; Wu, B; Xue, J, 2021) |
| "Twenty breast (58 ± 10 years) and 20 prostate cancer survivors (68 ± 6 years), 3." | 1.56 | Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO ( Rosenberger, F; Schlüter, K; Schneider, J; Sprave, T; Wiskemann, J, 2020) |
| "Despite considerable advances in prostate cancer research, there is a major need for a systemic delivery platform that efficiently targets anti-cancer drugs to sites of disseminated prostate cancer while minimizing host toxicity." | 1.43 | A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer. ( Bhagchandani, SH; Bhowmick, N; Brennen, WN; Denmeade, SR; Han, E; Heinelt, M; Isaacs, JT; Joshi, N; Karp, JM; Levy, O; Milton, Y; Musabeyezu, J; Ngai, J; Ranganath, S; Rosen, DM; Safaee, H; Wang, H, 2016) |
| "Then, a mouse model of prostate cancer was used to evaluate the anti-cancer effect of TFO-NP-Apt in vivo." | 1.43 | Aptamer-modified PLGA nanoparticle delivery of triplex forming oligonucleotide for targeted prostate cancer therapy. ( Guo, RM; Jiao, J; Zhang, Y; Zhu, S; Zou, MH; Zou, Q, 2016) |
| "Prostate cancer is one of the most common malignant tumors in males and it has become a major worldwide public health problem." | 1.43 | Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells. ( Barroso-Neto, IL; Caetano, EW; Cavalcanti, BC; Costa, MP; da Silva, EN; Di Fiore, S; Dias, GG; Feitosa, AC; Fischer, R; Freire, VN; Ladeira, LO; Oliveira, FC; Pessoa, C; Sales, FA; Sousa, BL, 2016) |
| "Saquinavir (SQV) is a US-FDA approved HIV protease inhibitor (HPI) for HIV cure." | 1.42 | Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity. ( Banerjee, S; Jain, NK; Kesharwani, P; Mehra, NK; Singh, R; Singh, S, 2015) |
| "We observed that prostate cancer cells did not rely mainly on glycolytic metabolism, while there was a high expression of MCT4 and CAIX - in CAFs." | 1.40 | A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer. ( Attig, J; Baltazar, F; Jurmeister, S; Lopes, C; Pértega-Gomes, N; Vizcaíno, JR, 2014) |
| "The treatment of prostate cancer has been impeded by the lack of both clinically relevant disease models and metabolic markers that track tumor progression." | 1.39 | Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. ( Keshari, KR; Kurhanewicz, J; Peehl, DM; Sriram, R; Van Criekinge, M; Vigneron, DB; Wang, ZJ; Wilson, DM, 2013) |
| " However, suboptimal pharmacokinetics and poor bioavailability limit its effective use in cancer therapeutics." | 1.38 | Design of curcumin loaded cellulose nanoparticles for prostate cancer. ( Chauhan, SC; Dobberpuhl, MR; Jaggi, M; Maher, DM; Yallapu, MM, 2012) |
| "Prostate cancer is the major cause of cancer death in men and the androgen receptor (AR) has been shown to play a critical role in the progression of the disease." | 1.38 | Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice. ( Berkland, C; Huang, Y; Li, B; Ling, M; Liu, J; Ran, Y; Thrasher, JB; Wang, Y; Xie, SX; Yang, J, 2012) |
| "Conversely, prostate cancer cells, upon contact with CAFs, were reprogrammed toward aerobic metabolism, with a decrease in GLUT1 expression and an increase in lactate upload via the lactate transporter MCT1." | 1.38 | Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. ( Chiarugi, P; Cirri, P; De Donatis, A; Fiaschi, T; Gandellini, P; Giannoni, E; Lanciotti, M; Marini, A; Serni, S; Taddei, ML, 2012) |
| " In normal rats, Michaelis-Menten kinetics were able to describe the dose-response of the fitted exchange rate constants with a 13." | 1.36 | Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. ( Albers, MJ; Bok, R; Chen, AP; Hurd, RE; Kurhanewicz, J; Nelson, SJ; Park, I; Tropp, J; Vigneron, DB; Yen, YF; Zhang, V; Zierhut, ML, 2010) |
| " However, the major disadvantage associated with the use of curcumin is its low systemic bioavailability when administered orally due to its poor aqueous solubility." | 1.35 | Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. ( Mukerjee, A; Vishwanatha, JK, 2009) |
| "PC-3 human prostate cancer cells have been cultivated in a rotating wall vessel in which glucose, lactate, and glutamine profiles were monitored noninvasively and in real time by near-infrared (NIR) spectroscopy." | 1.32 | On-line monitoring of human prostate cancer cells in a perfusion rotating wall vessel by near-infrared spectroscopy. ( Arnold, MA; Cohen, MB; Murhammer, DW; Rhiel, MH, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.90) | 18.7374 |
| 1990's | 3 (2.86) | 18.2507 |
| 2000's | 17 (16.19) | 29.6817 |
| 2010's | 71 (67.62) | 24.3611 |
| 2020's | 12 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Ippolito, L | 1 |
| Comito, G | 2 |
| Parri, M | 1 |
| Iozzo, M | 1 |
| Duatti, A | 1 |
| Virgilio, F | 1 |
| Lorito, N | 1 |
| Bacci, M | 1 |
| Pardella, E | 1 |
| Sandrini, G | 1 |
| Bianchini, F | 2 |
| Damiano, R | 1 |
| Ferrone, L | 1 |
| la Marca, G | 1 |
| Serni, S | 2 |
| Spatafora, P | 1 |
| Catapano, CV | 1 |
| Morandi, A | 2 |
| Giannoni, E | 3 |
| Chiarugi, P | 3 |
| Vovdenko, S | 1 |
| Morozov, A | 1 |
| Ali, S | 1 |
| Kogan, E | 1 |
| Bezrukov, E | 1 |
| Chen, YY | 1 |
| Luo, LP | 1 |
| Deng, KC | 1 |
| Ma, S | 1 |
| Chen, Y | 3 |
| Quan, P | 1 |
| Zhang, J | 3 |
| Han, S | 1 |
| Wang, G | 1 |
| Qi, R | 1 |
| Zhang, X | 2 |
| Wang, F | 2 |
| Yuan, J | 1 |
| Yang, X | 1 |
| Jia, W | 1 |
| Qin, W | 1 |
| Sahin, SI | 1 |
| Ji, X | 1 |
| Agarwal, S | 1 |
| Sinha, A | 1 |
| Mali, I | 1 |
| Gordon, JW | 6 |
| Mattingly, M | 1 |
| Subramaniam, S | 1 |
| Kurhanewicz, J | 8 |
| Larson, PEZ | 5 |
| Sriram, R | 2 |
| Sushentsev, N | 1 |
| Hamm, G | 1 |
| Richings, J | 1 |
| McLean, MA | 1 |
| Menih, IH | 1 |
| Ayyappan, V | 1 |
| Mills, IG | 1 |
| Warren, AY | 1 |
| Gnanapragasam, VJ | 1 |
| Barry, ST | 1 |
| Goodwin, RJA | 1 |
| Gallagher, FA | 1 |
| Barrett, T | 1 |
| El-Kenawi, A | 1 |
| Gatenbee, C | 1 |
| Robertson-Tessi, M | 1 |
| Bravo, R | 1 |
| Dhillon, J | 1 |
| Balagurunathan, Y | 1 |
| Berglund, A | 1 |
| Vishvakarma, N | 1 |
| Ibrahim-Hashim, A | 1 |
| Choi, J | 1 |
| Luddy, K | 1 |
| Gatenby, R | 1 |
| Pilon-Thomas, S | 1 |
| Anderson, A | 1 |
| Ruffell, B | 1 |
| Gillies, R | 1 |
| Granlund, KL | 2 |
| Tee, SS | 2 |
| Vargas, HA | 1 |
| Lyashchenko, SK | 1 |
| Reznik, E | 1 |
| Fine, S | 1 |
| Laudone, V | 1 |
| Eastham, JA | 1 |
| Touijer, KA | 1 |
| Reuter, VE | 1 |
| Gonen, M | 1 |
| Sosa, RE | 1 |
| Nicholson, D | 1 |
| Guo, YW | 1 |
| Chen, AP | 4 |
| Tropp, J | 3 |
| Robb, F | 1 |
| Hricak, H | 1 |
| Keshari, KR | 3 |
| Schlüter, K | 2 |
| Schneider, J | 2 |
| Sprave, T | 2 |
| Wiskemann, J | 2 |
| Rosenberger, F | 2 |
| Pereira-Nunes, A | 1 |
| Simões-Sousa, S | 2 |
| Pinheiro, C | 1 |
| Miranda-Gonçalves, V | 1 |
| Granja, S | 1 |
| Baltazar, F | 4 |
| Walker, CM | 1 |
| Xu, Z | 1 |
| Michel, KA | 1 |
| Li, L | 1 |
| Vigneron, DB | 11 |
| Bankson, JA | 1 |
| Cardoso, HJ | 1 |
| Figueira, MI | 1 |
| Vaz, CV | 3 |
| Carvalho, TMA | 1 |
| Brás, LA | 1 |
| Madureira, PA | 1 |
| Oliveira, PJ | 1 |
| Sardão, VA | 1 |
| Socorro, S | 3 |
| Xue, J | 1 |
| Pu, Y | 1 |
| Smith, J | 1 |
| Gao, X | 1 |
| Wang, C | 3 |
| Wu, B | 1 |
| Luker, GD | 1 |
| Wu, M | 2 |
| Wang, Y | 6 |
| Zhang, M | 1 |
| Luo, Y | 1 |
| Tang, J | 1 |
| Wang, Z | 3 |
| Wang, D | 1 |
| Hao, L | 1 |
| Gdowski, AS | 1 |
| Ranjan, A | 2 |
| Sarker, MR | 1 |
| Vishwanatha, JK | 2 |
| Gdowski, A | 1 |
| Johnson, K | 1 |
| Shah, S | 1 |
| Gryczynski, I | 1 |
| Vishwanatha, J | 1 |
| Qu, S | 1 |
| Xue, H | 1 |
| Dong, X | 1 |
| Lin, D | 1 |
| Wu, R | 2 |
| Nabavi, N | 1 |
| Collins, CC | 1 |
| Gleave, ME | 2 |
| Gout, PW | 1 |
| Milshteyn, E | 2 |
| von Morze, C | 2 |
| Zhu, Z | 1 |
| Sun, SC | 1 |
| Zhao, H | 1 |
| Liu, R | 1 |
| Wang, BL | 1 |
| Liu, YQ | 1 |
| Zhao, Y | 1 |
| Shi, ZD | 1 |
| Zhu, X | 1 |
| Bok, RA | 2 |
| Chen, HY | 1 |
| Autry, A | 1 |
| Park, I | 2 |
| Van Criekinge, M | 2 |
| Mammoli, D | 1 |
| Bok, R | 5 |
| Xu, D | 1 |
| Li, Y | 1 |
| Aggarwal, R | 1 |
| Chang, S | 1 |
| Slater, JB | 1 |
| Ferrone, M | 1 |
| Nelson, S | 1 |
| Clendinen, CS | 1 |
| Gaul, DA | 1 |
| Monge, ME | 1 |
| Arnold, RS | 1 |
| Edison, AS | 1 |
| Petros, JA | 1 |
| Fernández, FM | 1 |
| Kobus, T | 1 |
| Wright, AJ | 1 |
| Van Asten, JJ | 1 |
| Heerschap, A | 1 |
| Scheenen, TW | 2 |
| Zhao, L | 1 |
| Lu, YT | 1 |
| Li, F | 1 |
| Wu, K | 1 |
| Hou, S | 1 |
| Yu, J | 1 |
| Shen, Q | 1 |
| Wu, D | 1 |
| Song, M | 1 |
| OuYang, WH | 1 |
| Luo, Z | 1 |
| Lee, T | 1 |
| Fang, X | 1 |
| Shao, C | 1 |
| Xu, X | 2 |
| Garcia, MA | 1 |
| Chung, LW | 1 |
| Rettig, M | 1 |
| Tseng, HR | 1 |
| Posadas, EM | 1 |
| Wilson, DM | 1 |
| Wang, ZJ | 1 |
| Peehl, DM | 1 |
| Le Broc-Ryckewaert, D | 1 |
| Carpentier, R | 1 |
| Lipka, E | 1 |
| Daher, S | 1 |
| Vaccher, C | 1 |
| Betbeder, D | 1 |
| Furman, C | 1 |
| Xing, Y | 1 |
| Reed, GD | 2 |
| Pauly, JM | 3 |
| Kerr, AB | 3 |
| Larson, PE | 6 |
| Christensen, CE | 1 |
| Karlsson, M | 1 |
| Winther, JR | 1 |
| Jensen, PR | 1 |
| Lerche, MH | 1 |
| Snima, KS | 1 |
| Arunkumar, P | 1 |
| Jayakumar, R | 1 |
| Lakshmanan, VK | 1 |
| Pértega-Gomes, N | 3 |
| Vizcaíno, JR | 2 |
| Attig, J | 1 |
| Jurmeister, S | 2 |
| Lopes, C | 1 |
| Yao, MH | 1 |
| Ma, M | 1 |
| Jia, XQ | 1 |
| Xu, G | 1 |
| Xu, HX | 1 |
| Chen, HR | 1 |
| Hajikarimi, Z | 1 |
| Khoei, S | 1 |
| Khoee, S | 1 |
| Mahdavi, SR | 1 |
| Menon, JU | 1 |
| Tumati, V | 1 |
| Hsieh, JT | 1 |
| Nguyen, KT | 1 |
| Saha, D | 1 |
| Laustsen, C | 1 |
| Ardenkjaer-Larsen, JH | 1 |
| Pedersen, M | 1 |
| Ringgaard, S | 1 |
| Stødkilde-Jørgensen, H | 1 |
| Singh, R | 1 |
| Kesharwani, P | 1 |
| Mehra, NK | 1 |
| Singh, S | 1 |
| Banerjee, S | 1 |
| Jain, NK | 1 |
| Seto, E | 1 |
| Felisbino, S | 1 |
| Massie, CE | 1 |
| Coelho, R | 1 |
| Sandi, C | 1 |
| Ramos-Montoya, A | 1 |
| Asim, M | 1 |
| Tran, M | 1 |
| Oliveira, E | 1 |
| Lobo da Cunha, A | 1 |
| Maximo, V | 1 |
| Neal, DE | 1 |
| Fryer, LG | 1 |
| Zhu, Y | 1 |
| Sun, Y | 2 |
| Liu, W | 1 |
| Jiang, J | 1 |
| Guan, W | 1 |
| Zhang, Z | 1 |
| Duan, Y | 1 |
| Marques, R | 2 |
| Alves, MG | 2 |
| Oliveira, PF | 2 |
| Cavaco, JE | 1 |
| Maia, CJ | 2 |
| Breukels, V | 1 |
| Jansen, KC | 1 |
| van Heijster, FH | 1 |
| Capozzi, A | 1 |
| van Bentum, PJ | 1 |
| Schalken, JA | 1 |
| Comment, A | 1 |
| Taddei, ML | 2 |
| Calvani, M | 1 |
| Richichi, B | 1 |
| Raugei, G | 1 |
| Wong, N | 1 |
| Tang, D | 1 |
| Huerta, C | 1 |
| Aberturas, Mdel R | 1 |
| Molpeceres, J | 1 |
| Dauchy, RT | 1 |
| Hoffman, AE | 1 |
| Wren-Dail, MA | 1 |
| Hanifin, JP | 1 |
| Warfield, B | 1 |
| Brainard, GC | 1 |
| Xiang, S | 1 |
| Yuan, L | 1 |
| Hill, SM | 1 |
| Belancio, VP | 1 |
| Dauchy, EM | 1 |
| Smith, K | 1 |
| Blask, DE | 1 |
| Li, W | 2 |
| Cohen, A | 1 |
| Squires, J | 1 |
| Braas, D | 1 |
| Graeber, TG | 1 |
| Du, L | 2 |
| Li, G | 1 |
| Li, Z | 1 |
| Chen, X | 1 |
| Huang, J | 1 |
| Heger, Z | 1 |
| Gumulec, J | 1 |
| Ondrak, A | 1 |
| Skoda, J | 1 |
| Zitka, Z | 1 |
| Cernei, N | 1 |
| Masarik, M | 1 |
| Zitka, O | 1 |
| Adam, V | 1 |
| Levy, O | 1 |
| Brennen, WN | 1 |
| Han, E | 1 |
| Rosen, DM | 1 |
| Musabeyezu, J | 1 |
| Safaee, H | 1 |
| Ranganath, S | 1 |
| Ngai, J | 1 |
| Heinelt, M | 1 |
| Milton, Y | 1 |
| Wang, H | 2 |
| Bhagchandani, SH | 1 |
| Joshi, N | 1 |
| Bhowmick, N | 1 |
| Denmeade, SR | 1 |
| Isaacs, JT | 1 |
| Karp, JM | 1 |
| Maidens, J | 1 |
| Arcak, M | 1 |
| Jiao, J | 1 |
| Zou, Q | 1 |
| Zou, MH | 1 |
| Guo, RM | 1 |
| Zhu, S | 1 |
| Zhang, Y | 2 |
| Ray, S | 1 |
| Ghosh Ray, S | 1 |
| Mandal, S | 1 |
| Costa, MP | 1 |
| Feitosa, AC | 1 |
| Oliveira, FC | 1 |
| Cavalcanti, BC | 1 |
| da Silva, EN | 1 |
| Dias, GG | 1 |
| Sales, FA | 1 |
| Sousa, BL | 1 |
| Barroso-Neto, IL | 1 |
| Pessoa, C | 1 |
| Caetano, EW | 1 |
| Di Fiore, S | 1 |
| Fischer, R | 1 |
| Ladeira, LO | 1 |
| Freire, VN | 1 |
| Bharali, DJ | 1 |
| Sudha, T | 1 |
| Cui, H | 1 |
| Mian, BM | 1 |
| Mousa, SA | 1 |
| DiGialleonardo, V | 1 |
| Eskandari, R | 1 |
| Jeong, S | 1 |
| Miloushev, V | 1 |
| Poot, AJ | 1 |
| Truong, S | 1 |
| Alvarez, JA | 1 |
| Aldeborgh, HN | 1 |
| Ahmed, KK | 1 |
| Geary, SM | 1 |
| Salem, AK | 1 |
| Kubala, E | 1 |
| Muñoz-Álvarez, KA | 1 |
| Topping, G | 1 |
| Hundshammer, C | 1 |
| Feuerecker, B | 1 |
| Gómez, PA | 1 |
| Pariani, G | 1 |
| Schilling, F | 1 |
| Glaser, SJ | 1 |
| Schulte, RF | 1 |
| Menzel, MI | 1 |
| Schwaiger, M | 1 |
| Yan, J | 1 |
| Jia, Y | 1 |
| Liu, S | 1 |
| Tian, C | 1 |
| Pan, W | 1 |
| Liu, X | 1 |
| Albers, MJ | 2 |
| Cunningham, CH | 2 |
| Zierhut, ML | 3 |
| Zhang, VY | 1 |
| Kohler, SJ | 1 |
| Hurd, RE | 2 |
| Yen, YF | 2 |
| Nelson, SJ | 3 |
| Thakur, SB | 2 |
| Yaligar, J | 2 |
| Koutcher, JA | 2 |
| Lupo, JM | 1 |
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| Wartenberg, M | 1 |
| Richter, M | 1 |
| Datchev, A | 1 |
| Günther, S | 1 |
| Milosevic, N | 1 |
| Bekhite, MM | 1 |
| Figulla, HR | 1 |
| Aran, JM | 1 |
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| Fernández-Carballido, A | 1 |
| Gottfried, E | 1 |
| Rogenhofer, S | 1 |
| Waibel, H | 1 |
| Kunz-Schughart, LA | 1 |
| Reichle, A | 1 |
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| Peuker, A | 1 |
| Peter, K | 1 |
| Hartmannsgruber, G | 1 |
| Andreesen, R | 1 |
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| Bevan, CL | 1 |
| Waxman, J | 1 |
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| Cho, HS | 1 |
| Dong, Z | 1 |
| Pauletti, GM | 1 |
| Xu, H | 1 |
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| Wang, L | 1 |
| Ewing, RC | 1 |
| Huth, C | 1 |
| Shi, D | 1 |
| Dafni, H | 1 |
| Hu, S | 2 |
| Yoshihara, HA | 1 |
| Ward, CS | 1 |
| Venkatesh, HS | 1 |
| Ronen, SM | 2 |
| De Bari, L | 2 |
| Chieppa, G | 1 |
| Marra, E | 1 |
| Passarella, S | 2 |
| Mei, X | 1 |
| Li, X | 1 |
| Zhang, F | 1 |
| Jin, Y | 1 |
| Reed, G | 1 |
| Shin, P | 1 |
| Bokacheva, L | 1 |
| Carlin, S | 1 |
| Thaler, HT | 1 |
| Rizwan, A | 1 |
| Lupu, ME | 1 |
| Matei, CC | 1 |
| Zakian, KL | 1 |
| Yallapu, MM | 1 |
| Dobberpuhl, MR | 1 |
| Maher, DM | 1 |
| Jaggi, M | 1 |
| Chauhan, SC | 1 |
| Hasan, W | 1 |
| Chu, K | 1 |
| Gullapalli, A | 1 |
| Dunn, SS | 1 |
| Enlow, EM | 1 |
| Luft, JC | 1 |
| Tian, S | 1 |
| Napier, ME | 1 |
| Pohlhaus, PD | 1 |
| Rolland, JP | 1 |
| DeSimone, JM | 1 |
| Morze, Cv | 1 |
| Lustig, M | 1 |
| Yang, J | 1 |
| Xie, SX | 1 |
| Huang, Y | 1 |
| Ling, M | 1 |
| Liu, J | 1 |
| Ran, Y | 1 |
| Thrasher, JB | 1 |
| Berkland, C | 1 |
| Li, B | 1 |
| Ma, W | 1 |
| Chen, M | 1 |
| Kaushal, S | 1 |
| McElroy, M | 1 |
| Ozkan, C | 1 |
| Bouvet, M | 1 |
| Kruse, C | 1 |
| Grotjahn, D | 1 |
| Ichim, T | 1 |
| Minev, B | 1 |
| Mueller, M | 1 |
| Reichardt, W | 1 |
| Koerner, J | 1 |
| Groettrup, M | 1 |
| He, X | 1 |
| Jia, R | 1 |
| Xu, L | 1 |
| Liang, K | 1 |
| Shao, G | 1 |
| Huang, P | 1 |
| Fiaschi, T | 1 |
| Marini, A | 1 |
| Gandellini, P | 1 |
| De Donatis, A | 1 |
| Lanciotti, M | 1 |
| Cirri, P | 1 |
| Giatromanolaki, A | 1 |
| Koukourakis, MI | 1 |
| Koutsopoulos, A | 1 |
| Mendrinos, S | 1 |
| Sivridis, E | 1 |
| Lodi, A | 1 |
| Woods, SM | 1 |
| Moreira, PI | 1 |
| Swisher, CL | 1 |
| Moro, L | 1 |
| Panyam, J | 1 |
| Zhou, WZ | 1 |
| Prabha, S | 1 |
| Sahoo, SK | 1 |
| Labhasetwar, V | 1 |
| Sartor, O | 1 |
| Dineen, MK | 1 |
| Perez-Marreno, R | 1 |
| Chu, FM | 1 |
| Carron, GJ | 1 |
| Tyler, RC | 1 |
| KING, LR | 1 |
| HOLLAND, JM | 1 |
| COOPER, JF | 1 |
| FARID, I | 1 |
| Rhiel, MH | 1 |
| Cohen, MB | 1 |
| Arnold, MA | 1 |
| Murhammer, DW | 1 |
| Farokhzad, OC | 2 |
| Jon, S | 1 |
| Khademhosseini, A | 1 |
| Tran, TN | 1 |
| Lavan, DA | 1 |
| Langer, R | 2 |
| McCarthy, JR | 1 |
| Perez, JM | 1 |
| Brückner, C | 1 |
| Weissleder, R | 1 |
| Moffatt, S | 1 |
| Cristiano, RJ | 1 |
| Ferran, M | 1 |
| Giménez-Arnau, A | 1 |
| Toll, A | 1 |
| Yébenes, M | 1 |
| Baena, V | 1 |
| Lloreta, J | 1 |
| Pujol, RM | 1 |
| Cheng, J | 1 |
| Teply, BA | 1 |
| Sherifi, I | 1 |
| Sung, J | 1 |
| Luther, G | 1 |
| Gu, FX | 1 |
| Levy-Nissenbaum, E | 1 |
| Radovic-Moreno, AF | 1 |
| Gryparis, EC | 1 |
| Hatziapostolou, M | 1 |
| Papadimitriou, E | 1 |
| Avgoustakis, K | 1 |
| Lu, J | 1 |
| Jackson, JK | 1 |
| Burt, HM | 1 |
| Chumakova, OV | 1 |
| Liopo, AV | 1 |
| Andreev, VG | 1 |
| Cicenaite, I | 1 |
| Evers, BM | 1 |
| Chakrabarty, S | 1 |
| Pappas, TC | 1 |
| Esenaliev, RO | 1 |
| Fracalanza, S | 1 |
| Ficarra, V | 1 |
| Cavalleri, S | 1 |
| Galfano, A | 1 |
| Novara, G | 1 |
| Mangano, A | 1 |
| Plebani, M | 1 |
| Artibani, W | 1 |
| Berton, M | 1 |
| Benimetskaya, L | 1 |
| Allémann, E | 1 |
| Stein, CA | 1 |
| Gurny, R | 1 |
| Pilatus, U | 1 |
| Aboagye, E | 1 |
| Artemov, D | 1 |
| Mori, N | 1 |
| Ackerstaff, E | 1 |
| Bhujwalla, ZM | 1 |
| Erkkilä, K | 1 |
| Aito, H | 1 |
| Aalto, K | 1 |
| Pentikäinen, V | 1 |
| Dunkel, L | 1 |
| Toguchi, H | 1 |
| Ogawa, Y | 1 |
| Okada, H | 1 |
| Yamamoto, M | 1 |
| Yamanaka, H | 1 |
| Imai, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterization of Hyperpolarized Pyruvate MRI Reproducibility[NCT02421380] | 109 participants (Anticipated) | Interventional | 2015-04-30 | Recruiting | |||
| Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy[NCT04679233] | 0 participants (Actual) | Interventional | 2021-02-28 | Withdrawn (stopped due to PI has withdrawn from the program, the study never started.) | |||
| Hyperpolarized 13-C Pyruvate MRI Surveillance of Multiple Cancers[NCT05697406] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-02-01 | Not yet recruiting | ||
| A Phase 1 Ascending-dose Study to Assess the Safety and Tolerability and Imaging Potential of Hyperpolarized Pyruvate (13C) Injection in Subjects With Prostate Cancer[NCT01229618] | Phase 1 | 31 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Open Retropubic Radical Prostatectomy With Anterograde Anatomical Dissection Technique (RRP2A), Compared With Walsh Open Anatomical Retrograde Radical Prostatectomy (RRP)[NCT02687308] | 240 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for lactic acid and Cancer of Prostate
| Article | Year |
|---|---|
Role of monocarboxylate transporters and glucose transporters in prostate cancer.
Topics: Glucose; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Humans; Lactic Acid; | 2023 |
[Quantitative cellular metabolism can be estimated by hyperpolarized magnetic resonance].
Topics: Administration, Intravenous; Biosensing Techniques; Humans; Lactic Acid; Magnetic Resonance Imaging; | 2014 |
Lactate transporters in the context of prostate cancer metabolism: what do we know?
Topics: Animals; Energy Metabolism; Glycolysis; Humans; Lactic Acid; Male; Molecular Targeted Therapy; Monoc | 2014 |
[Once-a-month injectable microcapsules of leuprorelin acetate].
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Capsules; Delayed-Action Preparations; Drug Delivery | 1991 |
2 trials available for lactic acid and Cancer of Prostate
| Article | Year |
|---|---|
An eight-month clinical study of LA-2575 30.0 mg: a new 4-month, subcutaneous delivery system for leuprolide acetate in the treatment of prostate cancer.
Topics: Aged; Delayed-Action Preparations; Drug Delivery Systems; Humans; Injections, Subcutaneous; Lactic A | 2003 |
Fundamental study on the implantable LH-RH agonist/polymer and its use in a randomized trial for prostate cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Implants; Drug Screening Assays, Antit | 1990 |
99 other studies available for lactic acid and Cancer of Prostate
| Article | Year |
|---|---|
Lactate Rewires Lipid Metabolism and Sustains a Metabolic-Epigenetic Axis in Prostate Cancer.
Topics: Epigenesis, Genetic; Humans; Lactic Acid; Lipid Metabolism; Male; Prostate; Prostatic Neoplasms | 2022 |
Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.
Topics: Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; La | 2023 |
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cell Proliferation; Gene Ex | 2023 |
Metabolite-Specific Echo Planar Imaging for Preclinical Studies with Hyperpolarized
Topics: Animals; Echo-Planar Imaging; Humans; Lactic Acid; Magnetic Resonance Imaging; Male; Mice; Prostatic | 2023 |
Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence.
Topics: Humans; Lactic Acid; Male; Neoplasm Recurrence, Local; Prospective Studies; Prostate; Prostate-Speci | 2023 |
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer.
Topics: Animals; Bicarbonates; Cell Line, Tumor; Computer Simulation; Cytokines; Disease Progression; Extrac | 2019 |
Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1.
Topics: Aged; Carbon Isotopes; Humans; Kinetics; Lactic Acid; Magnetic Resonance Imaging; Male; Middle Aged; | 2020 |
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors.
Topics: Aged; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Energy Metabolism; Exercise Test; | 2019 |
Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO
Topics: Aged; Anaerobic Threshold; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Exercise Tes | 2020 |
Targeting lactate production and efflux in prostate cancer.
Topics: Animals; Biological Transport; Blotting, Western; Cell Movement; Cell Survival; Chick Embryo; Chorio | 2020 |
Slice profile effects on quantitative analysis of hyperpolarized pyruvate.
Topics: Area Under Curve; Computer Simulation; Humans; Lactic Acid; Magnetic Resonance Imaging; Male; Phanto | 2020 |
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.
Topics: Amino Acid Transport System ASC; Androgens; Anilides; Animals; Caspase 3; Cell Line, Tumor; Cell Mov | 2021 |
Identifying metastatic ability of prostate cancer cell lines using native fluorescence spectroscopy and machine learning methods.
Topics: Cell Line, Tumor; Humans; Lactic Acid; Machine Learning; Male; NAD; Neoplasm Metastasis; Principal C | 2021 |
Imaging Hyperpolarized Lactate in Prostate Cancer.
Topics: Humans; Hyperlactatemia; Lactic Acid; Magnetic Resonance Imaging; Male; Prostatic Neoplasms | 2019 |
Paclitaxel-loaded and A10-3.2 aptamer-targeted poly(lactide-
Topics: Animals; Antigens, Surface; Antineoplastic Agents, Phytogenic; Aptamers, Nucleotide; Cell Line, Tumo | 2017 |
Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain.
Topics: Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Dip | 2017 |
Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Curcumin; Drug Carriers; Drug Evalu | 2018 |
Aneustat (OMN54) has aerobic glycolysis-inhibitory activity and also immunomodulatory activity as indicated by a first-generation PDX prostate cancer model.
Topics: Aerobiosis; Animals; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Gene Expression Reg | 2018 |
High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-
Topics: Adenocarcinoma; Alanine; Animals; Carbon Isotopes; Image Processing, Computer-Assisted; Lactic Acid; | 2018 |
[Expression of long non-coding RNA H19 in prostate cancer and its effect on the proliferation and glycometabolism of human prostate cancer cells].
Topics: Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glucose; Humans; Lacti | 2017 |
Dynamic diffusion-weighted hyperpolarized
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Computer Simulation; Diffusion Magnetic Resonanc | 2019 |
Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.
Topics: Artifacts; Bicarbonates; Brain; Brain Neoplasms; Calibration; Carbon Isotopes; Carbon-13 Magnetic Re | 2019 |
Preoperative Metabolic Signatures of Prostate Cancer Recurrence Following Radical Prostatectomy.
Topics: Amino Acids; Big Data; Chromatography, Liquid; Citric Acid Cycle; Glucose; Humans; Lactic Acid; Magn | 2019 |
In vivo (1) H MR spectroscopic imaging of aggressive prostate cancer: can we detect lactate?
Topics: Aged; Aged, 80 and over; Algorithms; Biomarkers, Tumor; Computer Simulation; Humans; Lactic Acid; Ma | 2014 |
High-purity prostate circulating tumor cell isolation by a polymer nanofiber-embedded microchip for whole exome sequencing.
Topics: Cell Line, Tumor; Cell Separation; Exome; Genomics; Humans; Lactic Acid; Male; Microchip Analytical | 2013 |
Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor.
Topics: Biomarkers, Tumor; Bioreactors; Carbon Isotopes; Humans; Lactic Acid; Male; Metabolic Networks and P | 2013 |
Development of innovative paclitaxel-loaded small PLGA nanoparticles: study of their antiproliferative activity and their molecular interactions on prostatic cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endocytosis; | 2013 |
Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Biotransformation; Carbon Isotopes; Computer Simulation; Image | 2013 |
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glucose; Glycolysis; Humans; Lactic Acid; Male; NAD; Pro | 2014 |
Silymarin encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles: a prospective candidate for prostate cancer therapy.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Diffusion; Humans; Lactic | 2014 |
A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer.
Topics: Biological Transport; Energy Metabolism; Fibroblasts; Humans; Kallikreins; Lactic Acid; Male; Middle | 2014 |
Multifunctional Bi2S3/PLGA nanocapsule for combined HIFU/radiation therapy.
Topics: Animals; Apoptosis; Biocompatible Materials; Bismuth; Cell Line; Cell Proliferation; Contrast Media; | 2014 |
Evaluation of the cytotoxic effects of PLGA coated iron oxide nanoparticles as a carrier of 5- fluorouracil and mega-voltage X-ray radiation in DU145 prostate cancer cell line.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Chemoradiotherapy; Coated Materials, B | 2014 |
Polymeric nanoparticles for targeted radiosensitization of prostate cancer cells.
Topics: Cell Line, Tumor; Cell Survival; Chromones; DNA Breaks, Double-Stranded; DNA Repair; Drug Liberation | 2015 |
Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Compounding; Drug Del | 2015 |
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.
Topics: Binding Sites; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; E2F1 Transcription Factor; Gene E | 2015 |
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Progression; Drug Desi | 2015 |
In Vivo Molecular MRI Imaging of Prostate Cancer by Targeting PSMA with Polypeptide-Labeled Superparamagnetic Iron Oxide Nanoparticles.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Contrast Media; Ferric Compounds; Ferrocyanides; Gluta | 2015 |
Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes.
Topics: Androgens; Apoptosis; Blotting, Western; Cell Proliferation; Glucose; Glucose Transporter Type 1; Gl | 2016 |
Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with (13)C hyperpolarised NMR.
Topics: Biological Transport; Carbon-13 Magnetic Resonance Spectroscopy; Cell Count; Cell Line, Tumor; Extra | 2015 |
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Carcinoma; Carrier Proteins; Cell Line, Tumo | 2015 |
Nimesulide-loaded nanoparticles for the potential coadjuvant treatment of prostate cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell | 2015 |
Daytime Blue Light Enhances the Nighttime Circadian Melatonin Inhibition of Human Prostate Cancer Growth.
Topics: Animals; Blood Glucose; Cell Division; Circadian Rhythm; Corticosterone; Fatty Acids; Humans; Insuli | 2015 |
The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
Topics: Carcinoma, Neuroendocrine; Carcinoma, Small Cell; Cell Line, Tumor; Cell Proliferation; Cell Surviva | 2016 |
Influence of Long-Distance Bicycle Riding on Serum/Urinary Biomarkers of Prostate Cancer.
Topics: Bicycling; Biomarkers, Tumor; C-Reactive Protein; Humans; Lactic Acid; Male; Middle Aged; Prostate-S | 2016 |
A prodrug-doped cellular Trojan Horse for the potential treatment of prostate cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Drug Delivery Systems; Humans; La | 2016 |
Optimizing Flip Angles for Metabolic Rate Estimation in Hyperpolarized Carbon-13 MRI.
Topics: Algorithms; Animals; Carbon Isotopes; Computer Simulation; Disease Models, Animal; Image Processing, | 2016 |
Aptamer-modified PLGA nanoparticle delivery of triplex forming oligonucleotide for targeted prostate cancer therapy.
Topics: Animals; Aptamers, Nucleotide; Cell Line, Tumor; Humans; Lactic Acid; Male; Mice; Nanoparticles; Nan | 2016 |
Development of bicalutamide-loaded PLGA nanoparticles: preparation, characterization and in-vitro evaluation for the treatment of prostate cancer.
Topics: Anilides; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Design; Drug Liberation; Huma | 2017 |
Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells.
Topics: Antineoplastic Agents; Benzofurans; Capsules; Cell Line, Tumor; Cell Survival; Delayed-Action Prepar | 2016 |
Anti-CD24 nano-targeted delivery of docetaxel for the treatment of prostate cancer.
Topics: Animals; CD24 Antigen; Docetaxel; Drug Delivery Systems; Lactic Acid; Male; Mice; Mice, Nude; Nanopa | 2017 |
Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field.
Topics: Animals; Antibiotics, Antineoplastic; Humans; Lactic Acid; Magnetic Fields; Magnetic Resonance Imagi | 2016 |
Surface engineering tumor cells with adjuvant-loaded particles for use as cancer vaccines.
Topics: Adjuvants, Immunologic; Animals; Cancer Vaccines; Cell Line, Tumor; Cross-Linking Reagents; Drug Car | 2017 |
Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging.
Topics: Cell Line, Tumor; Fluorodeoxyglucose F18; Humans; Lactic Acid; Magnetic Resonance Imaging; Magnetic | 2016 |
Co-delivery of docetaxel and curcumin prodrug via dual-targeted nanoparticles with synergistic antitumor activity against prostate cancer.
Topics: Aconitic Acid; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Coumarins; Curcumin; Do | 2017 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.
Topics: Adenocarcinoma; Alanine; Animals; Biomarkers, Tumor; Carbon Isotopes; Disease Models, Animal; Lactic | 2008 |
In vivo lactate signal enhancement using binomial spectral-selective pulses in selective MQ coherence (SS-SelMQC) spectroscopy.
Topics: Algorithms; Animals; Biomarkers, Tumor; Cell Line, Tumor; Lactic Acid; Magnetic Resonance Spectrosco | 2009 |
Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer.
Topics: Animals; Biomarkers, Tumor; Carbon Isotopes; Diagnosis, Computer-Assisted; Disease Models, Animal; H | 2010 |
Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; Curcumin | 2009 |
Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice.
Topics: Alanine; Algorithms; Animals; Carbon Isotopes; Computer Simulation; Kinetics; Lactic Acid; Magnetic | 2010 |
Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1 | 2010 |
Effective antiproliferative effect of meloxicam on prostate cancer cells: development of a new controlled release system.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Delayed-Ac | 2010 |
Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids.
Topics: Cell Line, Tumor; Cell Proliferation; Chromans; Deoxyglucose; Humans; Hydrogen-Ion Concentration; Hy | 2011 |
Metabolic signatures of malignant progression in prostate epithelial cells.
Topics: Amino Acids; Animals; Biomarkers, Tumor; Cell Line; Choline; Disease Progression; Epithelial Cells; | 2011 |
Fluorescent, superparamagnetic nanospheres for drug storage, targeting, and imaging: a multifunctional nanocarrier system for cancer diagnosis and treatment.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Carriers; Fluorescent Dyes; Humans; | 2010 |
Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor.
Topics: Animals; Benzamides; Capillary Permeability; Carbon Isotopes; Humans; Hypoxia-Inducible Factor 1; Im | 2010 |
L-lactate metabolism can occur in normal and cancer prostate cells via the novel mitochondrial L-lactate dehydrogenase.
Topics: Carcinoma; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Humans; L-Lactate Dehydrogena | 2010 |
In-vitro/in-vivo studies of the biodegradable poly-(D,L-lactide-co-glycolide) microspheres of a novel luteinizing hormone-releasing hormone antagonist for prostate cancer treatment.
Topics: Animals; Antineoplastic Agents; Dioxanes; Drug Delivery Systems; Gonadotropin-Releasing Hormone; Hum | 2011 |
Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate.
Topics: Alanine; Algorithms; Animals; Carbon Isotopes; Computer Simulation; Image Processing, Computer-Assis | 2011 |
Lactate MRSI and DCE MRI as surrogate markers of prostate tumor aggressiveness.
Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Contrast Media; Immunohistochemistry; Lactic Acid; Magneti | 2012 |
Design of curcumin loaded cellulose nanoparticles for prostate cancer.
Topics: Apoptosis; beta-Cyclodextrins; Cell Line, Tumor; Cell Proliferation; Cellulose; Chemistry, Pharmaceu | 2012 |
Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer.
Topics: Animals; Coated Materials, Biocompatible; Genetic Therapy; Humans; Lactic Acid; Lipids; Male; Nanoca | 2012 |
A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate.
Topics: Animals; Carbon Isotopes; Cell Line, Tumor; Echo-Planar Imaging; Lactic Acid; Male; Mice; Mice, Tran | 2012 |
Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice.
Topics: Animals; Aptamers, Nucleotide; Cell Line, Tumor; Drug Delivery Systems; Genetic Therapy; Humans; Lac | 2012 |
PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses.
Topics: Animals; Antigen Presentation; Antigens, Neoplasm; Cancer Vaccines; Cell Line, Tumor; Dendritic Cell | 2012 |
Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Line; Drug Carriers; Humans; Immunization; Lac | 2012 |
³²P-chromic phosphate-Poly(L-Lactide) seeds of sustained release and their brachytherapy for prostate cancer with lymphatic metastasis.
Topics: Animals; Brachytherapy; Cell Line, Tumor; Chromium Compounds; Humans; Lactic Acid; Lymphatic Metasta | 2012 |
Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Fibroblasts; Gene Expression Regulati | 2012 |
The metabolic interactions between tumor cells and tumor-associated stroma (TAS) in prostatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Caveolin 1; Cell Communication; Cell Proliferation; Fibroblasts; Hum | 2012 |
Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Female; Humans; Lactic Acid; Male; MCF-7 Cells; Mito | 2013 |
Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile.
Topics: Alanine; Androgens; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glucose; Glucose Trans | 2012 |
A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates.
Topics: Adenocarcinoma; Algorithms; Animals; Electromagnetic Fields; Humans; Kinetics; L-Lactate Dehydrogena | 2012 |
Prostate cancer cells metabolize d-lactate inside mitochondria via a D-lactate dehydrogenase which is more active and highly expressed than in normal cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Kinetics; Lactate Dehydrogenases; Lacti | 2013 |
Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery.
Topics: Biological Transport; Cell Division; Cell Line; Cells, Cultured; Delayed-Action Preparations; Dexame | 2002 |
Serum lactic acid dehydrogenase (LDH) level in patients with prostatic cancer.
Topics: Humans; L-Lactate Dehydrogenase; Lactic Acid; Male; Prostatic Neoplasms | 1963 |
THE ROLE OF CITRIC ACID IN THE PHYSIOLOGY OF THE PROSTATE. 3. LACTATE/CITRATE RATIOS IN BENIGN AND MALIGNANT PROSTATIC HOMOGENATES AS AN INDEX OF PROSTATIC MALIGNANCY.
Topics: Chromatography; Citrates; Citric Acid; Citric Acid Cycle; Humans; Lactates; Lactic Acid; Male; Metab | 1964 |
On-line monitoring of human prostate cancer cells in a perfusion rotating wall vessel by near-infrared spectroscopy.
Topics: Ammonia; Bioreactors; Cell Culture Techniques; Cell Line, Tumor; Glucose; Glutamine; Humans; Lactic | 2004 |
Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells.
Topics: Antigens, Surface; Cell Line, Tumor; Drug Delivery Systems; Glutamate Carboxypeptidase II; Humans; L | 2004 |
Polymeric nanoparticle preparation that eradicates tumors.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diffusion; Drug Carriers; Lactic Acid; | 2005 |
PEGylated J591 mAb loaded in PLGA-PEG-PLGA tri-block copolymer for targeted delivery: in vitro evaluation in human prostate cancer cells.
Topics: Antibodies, Monoclonal; Cell Line, Tumor; DNA; Drug Delivery Systems; Humans; Lactic Acid; Male; Pla | 2006 |
Depot leuprorelin acetate-induced granulomas manifested as persistent suppurative nodules.
Topics: Aged; Delayed-Action Preparations; Granuloma; Humans; Injections, Subcutaneous; Lactic Acid; Leuprol | 2006 |
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.
Topics: Animals; Antineoplastic Agents; Drug Delivery Systems; Humans; Lactic Acid; Male; Mice; Models, Chem | 2007 |
Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells.
Topics: Antineoplastic Agents; Butanols; Cell Line, Tumor; Cisplatin; Humans; Lactic Acid; Male; Microscopy, | 2007 |
The preparation and characterization of anti-VEGFR2 conjugated, paclitaxel-loaded PLLA or PLGA microspheres for the systemic targeting of human prostate tumors.
Topics: Animals; Antibodies, Blocking; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Compounding | 2008 |
Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo.
Topics: Animals; beta-Galactosidase; Blotting, Western; Cell Line, Tumor; DNA; Drug Delivery Systems; Gene T | 2008 |
Is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy? Results from a prospective, unrandomized, comparative study.
Topics: Acute-Phase Reaction; Aged; C-Reactive Protein; Humans; Interleukin-1alpha; Interleukin-6; Lactic Ac | 2008 |
Uptake of oligonucleotide-loaded nanoparticles in prostatic cancer cells and their intracellular localization.
Topics: Humans; Lactic Acid; Male; Oligonucleotides; Polyesters; Polymers; Prostatic Neoplasms; Thionucleoti | 1999 |
Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Energy | 2001 |
Lactate inhibits germ cell apoptosis in the human testis.
Topics: Adenine; Aged; Aged, 80 and over; Apoptosis; Culture Techniques; fas Receptor; Humans; In Situ Nick- | 2002 |