lactic acid has been researched along with Cancer of Kidney in 25 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer." | 2.48 | Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target. ( Burrell, RA; Dykema, K; Endesfelder, D; Gerlinger, M; Howell, M; Jiang, M; Kelly, G; Larkin, J; Martinez, P; Patard, JJ; Rioux-Leclercq, N; Santos, CR; Saunders, RE; Spencer-Dene, B; Stamp, G; Swanton, C; Vetter, M, 2012) |
| "Lactic acid was previously considered a waste product of glycolysis, and has now become a key metabolite for cancer development, maintenance and metastasis." | 1.72 | Lactic Acid Metabolism and Transporter Related Three Genes Predict the Prognosis of Patients with Clear Cell Renal Cell Carcinoma. ( Chen, S; Guo, T; Tang, H; Wang, T; Wang, X; Yuan, Z; Zhang, D; Zhang, J, 2022) |
| "Patients with high-risk non-metastatic renal cell carcinoma (RCC) are at risk of metastatic relapse following nephrectomy." | 1.72 | Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma. ( Choy, YB; Kim, CR; Kim, SN; Lee, HW; Park, CG; Park, DH; Park, W; Seo, HS; Seo, SI; Yeom, SY, 2022) |
| "Determining the aggressiveness of renal cell carcinoma (RCC) noninvasively is a critical part of the diagnostic workup for treating this disease that kills more than 15,000 people annually in the USA." | 1.62 | Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models. ( Ahamed, F; Kurhanewicz, J; Larson, P; Sriram, R; Van Criekinge, M; Wang, ZJ, 2021) |
| "Everolimus is a drug used successfully in a number of different oncology indications, but significant on-target toxicities exist." | 1.46 | Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer. ( Guthy, D; Laborde, L; McSheehy, P; Oz, F; Ristov, M; Sterker, D, 2017) |
| " At maximum dosage and time (15 μM and 96 h), Sorafenib-loaded PLGA and HMC-coated liposomes killed 88." | 1.42 | Comparison of sorafenib-loaded poly (lactic/glycolic) acid and DPPC liposome nanoparticles in the in vitro treatment of renal cell carcinoma. ( Arora, J; Boonkaew, B; Callaghan, C; Chava, S; Dash, S; He, J; John, VT; Lee, BR; Liu, J; Maddox, MM; Mandava, SH, 2015) |
| "In a renal cell carcinoma cell (RCC) line, bidirectional exchange was observed." | 1.42 | Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates. ( Koelsch, B; Kurhanewicz, J; Larson, P; Leon Swisher, C; Santos, RD; Sriram, R; Sukumar, S; Vigneron, D; Wang, ZJ, 2015) |
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| "Renal cell carcinoma is the most lethal of the common urologic malignancies, with no available effective therapeutics." | 1.35 | Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts. ( Bharali, DJ; Davis, FB; Davis, PJ; Dyskin, E; Hercbergs, A; Lansing, L; Mousa, SA; Mousa, SS; Yalcin, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 10 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, JQ | 1 |
| Wang, CD | 1 |
| Tang, HY | 1 |
| Sang, BT | 1 |
| Liu, X | 1 |
| Yi, FP | 1 |
| Wu, XM | 1 |
| Sun, Z | 1 |
| Tao, W | 1 |
| Guo, X | 1 |
| Jing, C | 1 |
| Zhang, M | 1 |
| Wang, Z | 1 |
| Kong, F | 1 |
| Suo, N | 1 |
| Jiang, S | 1 |
| Wang, H | 1 |
| Guo, T | 1 |
| Zhang, J | 2 |
| Wang, T | 1 |
| Yuan, Z | 1 |
| Tang, H | 1 |
| Zhang, D | 1 |
| Chen, S | 1 |
| Wang, X | 1 |
| Lee, HW | 1 |
| Seo, HS | 1 |
| Yeom, SY | 1 |
| Kim, SN | 1 |
| Kim, CR | 1 |
| Park, DH | 1 |
| Park, W | 1 |
| Choy, YB | 1 |
| Park, CG | 1 |
| Seo, SI | 1 |
| Nizioł, J | 1 |
| Sunner, J | 1 |
| Beech, I | 1 |
| Ossoliński, K | 1 |
| Ossolińska, A | 1 |
| Ossoliński, T | 1 |
| Płaza, A | 1 |
| Ruman, T | 1 |
| Miranda-Gonçalves, V | 1 |
| Lameirinhas, A | 1 |
| Macedo-Silva, C | 1 |
| Lobo, J | 1 |
| C Dias, P | 1 |
| Ferreira, V | 1 |
| Henrique, R | 1 |
| Jerónimo, C | 1 |
| Min, X | 1 |
| Zhang, X | 1 |
| Li, Y | 2 |
| Cao, X | 1 |
| Cheng, H | 1 |
| Li, C | 1 |
| Kong, Q | 1 |
| Mao, Q | 1 |
| Peng, P | 1 |
| Ni, Y | 1 |
| Li, J | 1 |
| Duan, Y | 1 |
| Liu, L | 1 |
| Ding, Z | 1 |
| Ahamed, F | 1 |
| Van Criekinge, M | 2 |
| Wang, ZJ | 3 |
| Kurhanewicz, J | 3 |
| Larson, P | 2 |
| Sriram, R | 3 |
| Huang, J | 1 |
| Zhao, X | 1 |
| Li, X | 1 |
| Peng, J | 1 |
| Yang, W | 1 |
| Mi, S | 1 |
| Savchenko, AA | 1 |
| Borisov, AG | 1 |
| Belenyuk, VD | 1 |
| Moshev, AV | 1 |
| Laborde, L | 1 |
| Oz, F | 1 |
| Ristov, M | 1 |
| Guthy, D | 1 |
| Sterker, D | 1 |
| McSheehy, P | 1 |
| Xiao, ZD | 1 |
| Han, L | 1 |
| Lee, H | 1 |
| Zhuang, L | 1 |
| Zhang, Y | 1 |
| Baddour, J | 1 |
| Nagrath, D | 1 |
| Wood, CG | 1 |
| Gu, J | 1 |
| Wu, X | 1 |
| Liang, H | 1 |
| Gan, B | 1 |
| Wang, Q | 1 |
| Yan, Y | 1 |
| Guo, P | 1 |
| Xing, Y | 1 |
| Wang, Y | 1 |
| Qin, F | 1 |
| Zeng, Q | 1 |
| Liu, J | 1 |
| Boonkaew, B | 1 |
| Arora, J | 1 |
| Mandava, SH | 1 |
| Maddox, MM | 1 |
| Chava, S | 1 |
| Callaghan, C | 1 |
| He, J | 1 |
| Dash, S | 1 |
| John, VT | 1 |
| Lee, BR | 1 |
| Minton, DR | 1 |
| Fu, L | 1 |
| Chen, Q | 1 |
| Robinson, BD | 1 |
| Gross, SS | 1 |
| Nanus, DM | 1 |
| Gudas, LJ | 1 |
| Leisz, S | 1 |
| Schulz, K | 1 |
| Erb, S | 1 |
| Oefner, P | 1 |
| Dettmer, K | 1 |
| Mougiakakos, D | 1 |
| Wang, E | 1 |
| Marincola, FM | 1 |
| Stehle, F | 1 |
| Seliger, B | 1 |
| Leon Swisher, C | 1 |
| Koelsch, B | 1 |
| Sukumar, S | 1 |
| Santos, RD | 1 |
| Vigneron, D | 1 |
| Hansen, A | 1 |
| Vigneron, DB | 1 |
| Wilson, DM | 1 |
| Keshari, KR | 1 |
| Yalcin, M | 1 |
| Bharali, DJ | 1 |
| Lansing, L | 1 |
| Dyskin, E | 1 |
| Mousa, SS | 1 |
| Hercbergs, A | 1 |
| Davis, FB | 1 |
| Davis, PJ | 1 |
| Mousa, SA | 1 |
| Gerlinger, M | 1 |
| Santos, CR | 1 |
| Spencer-Dene, B | 1 |
| Martinez, P | 1 |
| Endesfelder, D | 1 |
| Burrell, RA | 1 |
| Vetter, M | 1 |
| Jiang, M | 1 |
| Saunders, RE | 1 |
| Kelly, G | 1 |
| Dykema, K | 1 |
| Rioux-Leclercq, N | 1 |
| Stamp, G | 1 |
| Patard, JJ | 1 |
| Larkin, J | 1 |
| Howell, M | 1 |
| Swanton, C | 1 |
| Marin-Valencia, I | 1 |
| Cho, SK | 1 |
| Rakheja, D | 1 |
| Hatanpaa, KJ | 1 |
| Kapur, P | 1 |
| Mashimo, T | 1 |
| Jindal, A | 1 |
| Vemireddy, V | 1 |
| Good, LB | 1 |
| Raisanen, J | 1 |
| Sun, X | 1 |
| Mickey, B | 1 |
| Choi, C | 1 |
| Takahashi, M | 1 |
| Togao, O | 1 |
| Pascual, JM | 1 |
| Deberardinis, RJ | 1 |
| Maher, EA | 1 |
| Malloy, CR | 1 |
| Bachoo, RM | 1 |
| RAMKISSOON, RA | 1 |
| CHAMBERLAIN, NO | 1 |
| BAKER, EL | 1 |
| JENNINGS, ER | 1 |
| Semenza, GL | 1 |
| Smits, GA | 1 |
| Cornel, EB | 1 |
| van de Boogert, E | 1 |
| Oosterhof, GO | 1 |
| Debruyne, FM | 1 |
| Schalken, JA | 1 |
| Heerschap, A | 1 |
| Chambrier, C | 1 |
| Mercatello, A | 1 |
| Tognet, E | 1 |
| Cottet-Emard, JM | 1 |
| Cohen, R | 1 |
| Blay, JY | 1 |
| Favrot, M | 1 |
| Philip, T | 1 |
| Beylot, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for lactic acid and Cancer of Kidney
| Article | Year |
|---|---|
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
Topics: Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell | 2012 |
HIF-1 mediates the Warburg effect in clear cell renal carcinoma.
Topics: Animals; Carcinoma, Renal Cell; Glucose; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Ind | 2007 |
23 other studies available for lactic acid and Cancer of Kidney
| Article | Year |
|---|---|
PDGF-BB/PDGFRβ promotes epithelial-mesenchymal transition by affecting PI3K/AKT/mTOR-driven aerobic glycolysis in Wilms' tumor G401 cells.
Topics: Becaplermin; Cell Line, Tumor; Cell Proliferation; Child; Epithelial-Mesenchymal Transition; Glucose | 2022 |
Construction of a Lactate-Related Prognostic Signature for Predicting Prognosis, Tumor Microenvironment, and Immune Response in Kidney Renal Clear Cell Carcinoma.
Topics: Carcinoma, Renal Cell; Female; Humans; Immunity; Kidney; Kidney Neoplasms; Lactic Acid; Male; Progno | 2022 |
Lactic Acid Metabolism and Transporter Related Three Genes Predict the Prognosis of Patients with Clear Cell Renal Cell Carcinoma.
Topics: Biomarkers, Tumor; Carcinoma, Renal Cell; Female; Gene Expression Regulation, Neoplastic; Humans; Ki | 2022 |
Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma.
Topics: Animals; Carcinoma, Renal Cell; Drug Carriers; Emulsions; Humans; Kidney Neoplasms; Lactic Acid; Lun | 2022 |
Localization of Metabolites of Human Kidney Tissue with Infrared Laser-Based Selected Reaction Monitoring Mass Spectrometry Imaging and Silver-109 Nanoparticle-Based Surface Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.
Topics: Amino Acids; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Lactic Acid; Lasers; Mass Spectrometry | 2020 |
Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Topics: Acetylation; Animals; Biological Transport; Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell | 2020 |
HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma.
Topics: Basigin; Biological Transport; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Prolifer | 2020 |
Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.
Topics: Alginates; Animals; Bioreactors; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Kidney Neoplasms; | 2021 |
HMGCR inhibition stabilizes the glycolytic enzyme PKM2 to support the growth of renal cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Carrier Proteins; Cell Line, Tumor; Cell Prol | 2021 |
Changes in the Subpopulation Composition and Phagocytic Activity of Monocytes in Patients with Kidney Cancer under the Influence of Metabolites In Vitro.
Topics: Adenosine Diphosphate; Adult; Biomarkers; Case-Control Studies; Cell Count; Female; Flow Cytometry; | 2021 |
Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Chr | 2017 |
Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.
Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Down-Regulation; Energy Metabolism; Genes, myc; Glucose; HE | 2017 |
RETRACTED: Physcion 8-O-β-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Down-Regul | 2018 |
Comparison of sorafenib-loaded poly (lactic/glycolic) acid and DPPC liposome nanoparticles in the in vitro treatment of renal cell carcinoma.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; | 2015 |
Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.
Topics: Aerobiosis; Animals; Carcinogenesis; Carcinoma, Renal Cell; Gene Expression Profiling; Gene Expressi | 2015 |
Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.
Topics: Adenosine Triphosphate; Amino Acids; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Energy M | 2015 |
Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates.
Topics: Alanine; Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Inhibitors; Enzymes; Humans; Kidney Neoplas | 2015 |
Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.
Topics: Biomarkers, Tumor; Bioreactors; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Hydrogen-Ion Concen | 2015 |
Tetraidothyroacetic acid (tetrac) and tetrac nanoparticles inhibit growth of human renal cell carcinoma xenografts.
Topics: Animals; Carcinoma, Renal Cell; Cell Growth Processes; Cell Line, Tumor; Chick Embryo; Chorioallanto | 2009 |
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
DIAGNOSTIC SIGNIFICANCE OF URINARY LACTIC ACID DEHYDROGENASE.
Topics: Adenocarcinoma; Albuminuria; Carcinoma, Papillary; Carcinoma, Transitional Cell; Clinical Enzyme Tes | 1964 |
Effects of high energy shock waves on tumor blood flow and metabolism: 31P/1H/2H nuclear magnetic resonance study.
Topics: Animals; Blood Circulation; Carcinoma, Renal Cell; Deuterium; Energy Metabolism; Humans; Hydrogen-Io | 1994 |
Hormonal and metabolic effects of chronic interleukin-2 infusion in cancer patients.
Topics: Adult; Carcinoma, Renal Cell; Epinephrine; Fatty Acids, Nonesterified; Female; Fever; Glycerol; Huma | 1990 |