lactic acid has been researched along with Cancer of Head in 44 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 5.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| "route, in various types of cancer disease such as non-small cell lung cancer and advanced breast cancer." | 2.67 | Experimental studies and preliminary clinical trial of vinorelbine-loaded polymeric bioresorbable implants for the local treatment of solid tumors. ( Bouffard, P; Caty, A; Fournier, C; Hecquet, B; Krikorian, A; Lefebvre, JL; Merle, S; Vanseymortier, L; Vert, M; Vilain, MO, 1991) |
| "Oral squamous cell carcinoma (OSCC) is also enriched with microbiota, while the significance of microbiota in shaping the OSCC microenvironment remains elusive." | 1.91 | F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production. ( Chen, G; Chen, L; Huang, X; Lei, H; Sun, J; Tang, Q; Wan, Q; Wo, K; Xie, M; Yin, Y; Yu, S; Zhang, J; Zheng, W, 2023) |
| "However, its role in laryngeal squamous cell carcinoma (LSCC) remains unclear." | 1.91 | A novel tyrosine tRNA-derived fragment, tRF ( Cao, J; Chen, X; Guo, Y; Li, W; Liu, M; Liu, Y; Sun, Y; Tian, L; Wang, J; Xu, L; Yang, Z; Zhang, J; Zhao, B; Zhao, R, 2023) |
| "Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral and maxillofacial malignancies, characterized by a low five-year survival rate primarily caused by invasion and metastasis." | 1.91 | Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. ( Huang, W; Jiang, M; Li, B; Lin, Y; Qi, Y, 2023) |
| "We prospectively analyzed 82 cases of head and neck cancer reconstruction (62 men and 20 women; mean age, 64." | 1.51 | A Simple Way to Measure Glucose and Lactate Values During Free Flap Head and Neck Reconstruction Surgery. ( Ishida, K; Kishi, K; Makino, Y; Miyawaki, T, 2019) |
| "Many cancers including head and neck squamous cell carcinoma (HNSCC) are characterized by a metabolic rewiring with increased glucose uptake and lactate production, termed as aerobic glycolysis." | 1.46 | Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma. ( Chen, G; Jia, J; Li, HM; Liu, ZJ; Ren, JG; Wang, WM; Yang, JG; Yu, ZL; Zhang, W, 2017) |
| "Monitoring surgical removal of oral squamous cell carcinomas (OSCC) is being routinely performed through clinical and imaging follow-up." | 1.43 | Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase. ( Biegner, T; Calgéer, B; Grimm, M; Hoefert, S; Kraut, W; Krimmel, M; Munz, A; Reinert, S; Teriete, P, 2016) |
| "Herein, we analyzed biopsies of primary squamous cell carcinoma after surgery and adjuvant irradiation in 17 patients." | 1.43 | Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years. ( Blatt, S; Mueller-Klieser, W; Pabst, AM; Sagheb, K; Schroeder, T; Voelxen, N; Walenta, S; Ziebart, T, 2016) |
| "Here, we interrogated head and neck cancer (HNSCC) specimens (n = 12) to examine if different metabolic compartments (oxidative vs." | 1.39 | Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer. ( Ames, JA; Anantharaman, A; Butera, A; Cognetti, DM; Curry, JM; Leiby, B; Lisanti, MP; Martinez-Outschoorn, UE; Sotgia, F; Tuluc, M; Whitaker-Menezes, D, 2013) |
| "In head and neck squamous cell carcinoma (HNSCC) aerobic glycolysis is the key feature for energy supply of the tumor." | 1.39 | Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer. ( Himpe, B; Nitsch, S; Pries, R; Schroeder, U; Vonthein, R; Wollenberg, B, 2013) |
| "A high lactate content in malignant head and neck cancer (Head and neck squamous cell carcinomas, HNSCC) is associated with a higher risk of metastatic spread and lower overall patient survival." | 1.37 | Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue. ( Kunkel, M; Mueller-Klieser, W; Reichert, TE; Wagner, W; Walenta, S; Ziebart, T, 2011) |
| "A panel of 15 HNSCC cell lines was assayed for glucose and glutamine dependence and sensitivity to metabolic inhibitors." | 1.37 | Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. ( Davis-Malesevich, M; Fokt, I; Frederick, MJ; Myers, JN; Ow, TJ; Pickering, CR; Priebe, W; Sandulache, VC; Zhou, G, 2011) |
| "Treatment of head and neck cancer could be improved and perhaps standardized if reliable markers for tumor progression and poor prognosis could be developed." | 1.33 | Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy. ( Bezabeh, T; Kerr, P; Nason, R; Odlum, O; Patel, R; Smith, IC; Sutherland, D, 2005) |
| "Five human head and neck squamous cell carcinoma cell lines (HNSCCs) xenografted in nude mice were treated with a clinically relevant irradiation protocol with 30 fractions within 6 weeks." | 1.33 | Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. ( Baumann, M; Mueller-Klieser, W; Quennet, V; Rosner, A; Walenta, S; Yaromina, A; Zips, D, 2006) |
| "A total of 22 NZW rabbits with VX2 squamous cell carcinomas transplanted into the auricles were intra-arterially (i." | 1.31 | Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits. ( Dullens, HF; Koole, R; Nijsen, JF; Slootweg, PJ; van Es, RJ; van het Schip, AD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.55) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 12 (27.27) | 29.6817 |
| 2010's | 20 (45.45) | 24.3611 |
| 2020's | 7 (15.91) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, J | 1 |
| Tang, Q | 1 |
| Yu, S | 1 |
| Xie, M | 1 |
| Zheng, W | 1 |
| Chen, G | 2 |
| Yin, Y | 1 |
| Huang, X | 1 |
| Wo, K | 1 |
| Lei, H | 1 |
| Zhang, J | 3 |
| Wan, Q | 1 |
| Chen, L | 1 |
| Haider, M | 1 |
| Jagal, J | 1 |
| Bajbouj, K | 1 |
| Sharaf, BM | 1 |
| Sahnoon, L | 1 |
| Okendo, J | 1 |
| Semreen, MH | 1 |
| Hamda, M | 1 |
| Soares, NC | 1 |
| Zhao, R | 1 |
| Yang, Z | 1 |
| Zhao, B | 1 |
| Li, W | 1 |
| Liu, Y | 1 |
| Chen, X | 1 |
| Cao, J | 1 |
| Guo, Y | 1 |
| Xu, L | 1 |
| Wang, J | 1 |
| Sun, Y | 1 |
| Liu, M | 1 |
| Tian, L | 1 |
| Lin, Y | 1 |
| Qi, Y | 1 |
| Jiang, M | 1 |
| Huang, W | 1 |
| Li, B | 1 |
| Dakpé, S | 1 |
| Colin, E | 1 |
| Bettoni, J | 1 |
| Davrou, J | 1 |
| Diouf, M | 1 |
| Devauchelle, B | 1 |
| Testelin, S | 1 |
| Ohashi, T | 2 |
| Terasawa, K | 1 |
| Aoki, M | 2 |
| Akazawa, T | 2 |
| Shibata, H | 1 |
| Kuze, B | 2 |
| Asano, T | 1 |
| Kato, H | 1 |
| Miyazaki, T | 1 |
| Matsuo, M | 1 |
| Inoue, N | 2 |
| Ito, Y | 2 |
| Chang, H | 1 |
| Xu, Q | 2 |
| Li, J | 2 |
| Li, M | 1 |
| Zhang, Z | 1 |
| Ma, H | 1 |
| Yang, X | 1 |
| Tomita, H | 1 |
| Sato, K | 1 |
| Mizuta, K | 1 |
| Hara, A | 1 |
| Nagaoka, H | 1 |
| He, H | 1 |
| Markoutsa, E | 1 |
| Zhan, Y | 1 |
| Xu, P | 1 |
| Yu, W | 1 |
| Chen, Y | 3 |
| Dubrulle, J | 1 |
| Stossi, F | 1 |
| Putluri, V | 1 |
| Sreekumar, A | 1 |
| Putluri, N | 1 |
| Baluya, D | 1 |
| Lai, SY | 3 |
| Sandulache, VC | 4 |
| Kishi, K | 1 |
| Ishida, K | 1 |
| Makino, Y | 1 |
| Miyawaki, T | 1 |
| Mehibel, M | 1 |
| Ortiz-Martinez, F | 1 |
| Voelxen, N | 2 |
| Boyers, A | 1 |
| Chadwick, A | 1 |
| Telfer, BA | 1 |
| Mueller-Klieser, W | 7 |
| West, CM | 1 |
| Critchlow, SE | 1 |
| Williams, KJ | 1 |
| Stratford, IJ | 1 |
| Curry, JM | 1 |
| Tuluc, M | 1 |
| Whitaker-Menezes, D | 1 |
| Ames, JA | 1 |
| Anantharaman, A | 1 |
| Butera, A | 1 |
| Leiby, B | 1 |
| Cognetti, DM | 1 |
| Sotgia, F | 1 |
| Lisanti, MP | 1 |
| Martinez-Outschoorn, UE | 1 |
| Schroeder, U | 1 |
| Himpe, B | 1 |
| Pries, R | 1 |
| Vonthein, R | 1 |
| Nitsch, S | 1 |
| Wollenberg, B | 1 |
| Clatot, F | 1 |
| Gouérant, S | 1 |
| Mareschal, S | 1 |
| Cornic, M | 1 |
| Berghian, A | 1 |
| Choussy, O | 1 |
| El Ouakif, F | 1 |
| François, A | 1 |
| Bénard, M | 1 |
| Ruminy, P | 1 |
| Picquenot, JM | 1 |
| Jardin, F | 1 |
| Dittmann, K | 1 |
| Mayer, C | 1 |
| Paasch, A | 1 |
| Huber, S | 1 |
| Fehrenbacher, B | 1 |
| Schaller, M | 1 |
| Rodemann, HP | 1 |
| Skinner, HD | 2 |
| Lu, T | 1 |
| Feng, L | 3 |
| Court, LE | 1 |
| Myers, JN | 3 |
| Meyn, RE | 2 |
| Fuller, CD | 2 |
| Bankson, JA | 2 |
| Grimm, M | 1 |
| Krimmel, M | 1 |
| Hoefert, S | 1 |
| Kraut, W | 1 |
| Calgéer, B | 1 |
| Biegner, T | 1 |
| Teriete, P | 1 |
| Munz, A | 1 |
| Reinert, S | 1 |
| Blatt, S | 1 |
| Sagheb, K | 1 |
| Pabst, AM | 1 |
| Walenta, S | 6 |
| Schroeder, T | 2 |
| Ziebart, T | 2 |
| Masloub, SM | 1 |
| Elmalahy, MH | 1 |
| Sabry, D | 1 |
| Mohamed, WS | 1 |
| Ahmed, SH | 1 |
| Zhang, Q | 1 |
| Ishida, Y | 1 |
| Hajjar, S | 1 |
| Tang, X | 1 |
| Shi, H | 1 |
| Dang, CV | 1 |
| Le, AD | 1 |
| Li, HM | 1 |
| Yang, JG | 1 |
| Liu, ZJ | 1 |
| Wang, WM | 1 |
| Yu, ZL | 1 |
| Ren, JG | 1 |
| Zhang, W | 1 |
| Jia, J | 1 |
| William, WN | 1 |
| Mijiti, A | 1 |
| Konopleva, MY | 1 |
| Wigfield, SM | 1 |
| Winter, SC | 1 |
| Giatromanolaki, A | 1 |
| Taylor, J | 1 |
| Koukourakis, ML | 1 |
| Harris, AL | 1 |
| Ping, Y | 1 |
| Jian, Z | 1 |
| Yi, Z | 1 |
| Huoyu, Z | 1 |
| Yuqiong, Y | 1 |
| Shixi, L | 1 |
| Sattler, UG | 2 |
| Meyer, SS | 1 |
| Quennet, V | 2 |
| Hoerner, C | 1 |
| Knoerzer, H | 1 |
| Fabian, C | 1 |
| Yaromina, A | 2 |
| Zips, D | 2 |
| Baumann, M | 2 |
| Kunkel, M | 1 |
| Reichert, TE | 1 |
| Wagner, W | 1 |
| Ow, TJ | 1 |
| Pickering, CR | 1 |
| Frederick, MJ | 1 |
| Zhou, G | 1 |
| Fokt, I | 1 |
| Davis-Malesevich, M | 1 |
| Priebe, W | 1 |
| MOIROUD, P | 1 |
| BONNEAU, H | 1 |
| Bezabeh, T | 1 |
| Odlum, O | 1 |
| Nason, R | 1 |
| Kerr, P | 1 |
| Sutherland, D | 1 |
| Patel, R | 1 |
| Smith, IC | 1 |
| Rosner, A | 1 |
| Zhou, S | 1 |
| Kachhap, S | 1 |
| Sun, W | 1 |
| Wu, G | 1 |
| Chuang, A | 1 |
| Poeta, L | 1 |
| Grumbine, L | 1 |
| Mithani, SK | 1 |
| Chatterjee, A | 1 |
| Koch, W | 1 |
| Westra, WH | 1 |
| Maitra, A | 1 |
| Glazer, C | 1 |
| Carducci, M | 1 |
| Sidransky, D | 1 |
| McFate, T | 1 |
| Verma, A | 1 |
| Califano, JA | 1 |
| Desai, KG | 1 |
| Mallery, SR | 1 |
| Schwendeman, SP | 1 |
| Le, QT | 1 |
| Koong, A | 1 |
| Lieskovsky, YY | 1 |
| Narasimhan, B | 1 |
| Graves, E | 1 |
| Pinto, H | 1 |
| Brown, JM | 2 |
| Spielman, D | 1 |
| Tamulevicius, P | 1 |
| Streffer, C | 1 |
| Adalsteinsson, E | 2 |
| Spielman, DM | 2 |
| Pauly, JM | 1 |
| Terris, DJ | 2 |
| Sommer, G | 1 |
| Macovski, A | 1 |
| Star-Lack, JM | 1 |
| Adam, MF | 1 |
| Pinto, HA | 1 |
| Smith, TA | 1 |
| Titley, J | 1 |
| Brizel, DM | 1 |
| Scher, RL | 1 |
| Clough, RW | 1 |
| Dewhirst, MW | 1 |
| van Es, RJ | 2 |
| Nijsen, JF | 2 |
| Dullens, HF | 2 |
| Kicken, M | 1 |
| van der Bilt, A | 1 |
| Hennink, W | 1 |
| Koole, R | 2 |
| Slootweg, PJ | 2 |
| van het Schip, AD | 1 |
| Fournier, C | 1 |
| Hecquet, B | 1 |
| Bouffard, P | 1 |
| Vert, M | 1 |
| Caty, A | 1 |
| Vilain, MO | 1 |
| Vanseymortier, L | 1 |
| Merle, S | 1 |
| Krikorian, A | 1 |
| Lefebvre, JL | 1 |
| Richtsmeier, WJ | 1 |
| Dauchy, R | 1 |
| Sauer, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Concurrent Angiogenic and EGFR Blockade in Conjunction With Curative Intent Chemoradiation for Locally Advanced Head and Neck Cancer[NCT00140556] | Early Phase 1 | 28 participants (Actual) | Interventional | 2005-08-31 | Completed | ||
| Feasibility of Holmium-166 Microspheres for Selective Intra-tumoural Treatment in Head and Neck Cancer: Biodistribution and Safety in Patients With Malignancy of the Tongue[NCT02975739] | 1 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Slow accrual) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response (resolution) of tumor on clinical exam. (NCT00140556)
Timeframe: Within 30 days of completing RT
| Intervention | Participants (Number) |
|---|---|
| Entire Study Population | 25 |
2 trials available for lactic acid and Cancer of Head
| Article | Year |
|---|---|
In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Choline; Creatine; Head and Neck Neoplasms; Humans; Lactic Ac | 2000 |
Experimental studies and preliminary clinical trial of vinorelbine-loaded polymeric bioresorbable implants for the local treatment of solid tumors.
Topics: Adult; Animals; Antineoplastic Agents; Delayed-Action Preparations; Dogs; Dose-Response Relationship | 1991 |
42 other studies available for lactic acid and Cancer of Head
| Article | Year |
|---|---|
F. nucleatum facilitates oral squamous cell carcinoma progression via GLUT1-driven lactate production.
Topics: Carcinoma, Squamous Cell; Glucose Transporter Type 1; GTPase-Activating Proteins; Head and Neck Neop | 2023 |
Integrated multi-omics analysis reveals unique signatures of paclitaxel-loaded poly(lactide-co-glycolide) nanoparticles treatment of head and neck cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Head and Neck Neoplasms; Humans; Lactic Acid | 2023 |
A novel tyrosine tRNA-derived fragment, tRF
Topics: Carcinogenesis; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Lactate Deh | 2023 |
Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplas | 2023 |
Intraosseous microdialysis for bone free flap monitoring in head and neck reconstructive surgery: A prospective pilot study.
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Facial Bones; Female; Fibula; Free Tissue Flaps; Glucose; H | 2020 |
The importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC.
Topics: Aged; Aged, 80 and over; Antigens, CD; Antigens, Differentiation, Myelomonocytic; C-Reactive Protein | 2020 |
Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC.
Topics: Base Sequence; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Galectins; Gen | 2021 |
M2-like macrophage polarization in high lactic acid-producing head and neck cancer.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers, Tumor; Carcinoma, Squamous Cell | 2017 |
Mussel-inspired PLGA/polydopamine core-shell nanoparticle for light induced cancer thermochemotherapy.
Topics: Animals; Bivalvia; Cell Line, Tumor; Doxorubicin; Drug Delivery Systems; ErbB Receptors; Head and Ne | 2017 |
Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.
Topics: Animals; Antineoplastic Agents; Carbon; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Citri | 2018 |
A Simple Way to Measure Glucose and Lactate Values During Free Flap Head and Neck Reconstruction Surgery.
Topics: Adult; Aged; Aged, 80 and over; Female; Free Tissue Flaps; Glucose; Head and Neck Neoplasms; Humans; | 2019 |
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.
Topics: Animals; Biomarkers; Head and Neck Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors | 2018 |
Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Differentiation; Cell Proliferation; Epithelial Cel | 2013 |
Decline of lactate in tumor tissue after ketogenic diet: in vivo microdialysis study in patients with head and neck cancer.
Topics: Aged; Carcinoma, Squamous Cell; Circadian Rhythm; Diet, Ketogenic; Female; Glucose; Head and Neck Ne | 2013 |
The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Carcinoma, Squamous Cell; Extracellular Matrix; Femal | 2014 |
Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production.
Topics: Blotting, Western; Bronchial Neoplasms; Cell Line, Tumor; Cell Nucleus; Dasatinib; ErbB Receptors; E | 2015 |
Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model.
Topics: Animals; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Carcinoma, Squamous Cell; Cell Line, Tu | 2015 |
Monitoring a 'metabolic shift' after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase.
Topics: Biomarkers, Tumor; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Immuno | 2016 |
Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Head and Neck Neopla | 2016 |
Comparative evaluation of PLGA nanoparticle delivery system for 5-fluorouracil and curcumin on squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Curcumin; Drug | 2016 |
EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; CD24 Anti | 2017 |
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2017 |
Metabolic interrogation as a tool to optimize chemotherapeutic regimens.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug | 2017 |
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
Topics: Base Sequence; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Primers; Gene Silencing; Head and Nec | 2008 |
Inhibition of the EGFR with nanoparticles encapsulating antisense oligonucleotides of the EGFR enhances radiosensitivity in SCCVII cells.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Combined Modality Therapy; Drug Comp | 2010 |
Glycolytic metabolism and tumour response to fractionated irradiation.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Dose Fractionation, Rad | 2010 |
Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.
Topics: Adenosine Triphosphate; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blotting, Western; Carcin | 2011 |
Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.
Topics: Adenosine Triphosphate; Carcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Prol | 2011 |
[Excision of a cervical metastasis of an undiscovered spinocellular malpighian epithelioma: absence of recurrence 12 years later, failure to lactate the primary lesion].
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Lactic Acid; Neoplasm Recurrence, Local; | 1955 |
Prediction of treatment response in head and neck cancer by magnetic resonance spectroscopy.
Topics: Carcinoma, Squamous Cell; Choline; Creatine; Female; Head and Neck Neoplasms; Humans; Lactic Acid; L | 2005 |
Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Fe | 2006 |
A bioluminescence technique for quantitative and structure-associated imaging of pyruvate.
Topics: Biological Assay; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Diagnostic Imaging; Froze | 2007 |
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
Topics: DNA, Mitochondrial; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; HeLa Cells; Hum | 2007 |
Formulation and characterization of injectable poly(DL-lactide-co-glycolide) implants loaded with N-acetylcysteine, a MMP inhibitor.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Calcium Compounds; Calorimetry, Differential Scannin | 2008 |
In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Female; Head and Neck N | 2008 |
Metabolic imaging in tumours by means of bioluminescence.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Carcinoma, Squamous Cell; Cell Death; Colorectal Ne | 1995 |
Feasibility study of lactate imaging of head and neck tumors.
Topics: Adult; Aged; Feasibility Studies; Female; Head and Neck Neoplasms; Humans; Lactic Acid; Magnetic Res | 1998 |
Deoxyglucose uptake by a head and neck squamous carcinoma: influence of changes in proliferative fraction.
Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Count; Fluorodeoxyglucose F18; Head and Neck Neoplasms; H | 2000 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
Topics: Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Follow-Up Studies; Head and Neck Neoplasm | 2001 |
Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study.
Topics: Analysis of Variance; Animals; Brachytherapy; Dextrans; Embolization, Therapeutic; Extravasation of | 2001 |
Intra-arterial embolization of head-and-neck cancer with radioactive holmium-166 poly(L-lactic acid) microspheres: an experimental study in rabbits.
Topics: Animals; Arteries; Brachytherapy; Carcinoma, Squamous Cell; Ear, External; Embolization, Therapeutic | 2001 |
In vivo nutrient uptake by head and neck cancers.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Glucose; Head and Neck Neoplasms; Humans; Hydroxybutyrates; La | 1987 |