lactic acid has been researched along with Breast Neoplasms in 308 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we synthesized a novel nanostructure for the co-delivery of curcumin and siRNA to breast cancer cells." | 8.12 | Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles. ( Azedi, F; Bayandori, M; Hamblin, MR; Hasanzadeh, A; Heidari, E; Karimi, M; Mohammad Gholinia Sarpoli, L; Zare-Karizi, S, 2022) |
| " In the present study, we evaluated the efficacy of CD73-specific siRNA-loaded chitosan-lactate nanoparticles (ChLa NPs) in combination with tumor lysate pulsed dendritic cells (DCs) vaccine in treatment of 4T1 (murine derived) breast cancer bearing mice." | 7.85 | CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. ( Ajami, M; Arab, S; Atyabi, F; Habibi, S; Hadjati, J; Hassannia, H; Jadidi-Niaragh, F; Kheshtchin, N; Masoumi, F; Mirsanei, Z; Noorbakhsh, F; Rastegari, A; Shokri, F, 2017) |
| " The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer." | 7.83 | Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer. ( Mukerjee, A; Ranjan, AP; Vishwanatha, JK, 2016) |
| "In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells." | 7.83 | A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR. ( Akbarzadeh, A; Barkhordari, A; Ghasemali, S; Kordi, S; Rahmati, YM; Tozihi, M; Zarghami, N, 2016) |
| "A folate-receptor-targeted poly (lactide-co-Glycolide) (PLGA)-Polyethylene glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into breast cancer cells." | 7.83 | Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations. ( Dinarvand, R; Esfandyari-Manesh, M; Faghihi, S; Fasehee, H; Ghaffari, SH; Ghavamzadeh, A; Moradian, H, 2016) |
| "Paclitaxel is a commonly used agent for breast cancer therapy, which comes across the obstacle "drug resistance", resulting in shortened overall survival of patients." | 7.83 | PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production. ( Cao, Z; Ge, X; Gu, Y; Han, M; Li, J; Lyu, P; Wang, F; Xia, W; Yu, Z, 2016) |
| "This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer." | 7.81 | Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. ( Ghosh, S; Haldar, C; Maiti, P; Pandey, SK, 2015) |
| " With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release." | 7.81 | Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells. ( Chen, C; Hu, K; Li, J; Liu, J; Liu, Y; Liu, Z; Sheng, W; Tang, J; Wu, Y; Zhang, J; Zhao, Y; Zhou, H, 2015) |
| "The present study was performed to investigate the therapeutic performance of polymer-lipid hybrid nanoparticles towards the delivery of lapatinib (LPT) in breast cancers." | 7.81 | Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation. ( Huo, ZJ; Liu, K; Liu, P; Pang, B; Wang, SJ; Wang, ZQ; Zuo, WS, 2015) |
| "Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients." | 7.81 | Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. ( Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH, 2015) |
| "The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer." | 7.79 | Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013) |
| "In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation." | 7.79 | Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. ( Araújo, I; Correia-Branco, A; Costa, T; Faria, A; Keating, E; Martel, F; Moreira, L, 2013) |
| "A star-shaped biodegradable polymer, mannitol-core poly(d,l-lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (M-PLGA-TPGS), was synthesized in order to provide a novel nanoformulation for breast cancer chemotherapy." | 7.79 | Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy. ( Huang, L; Liu, T; Mei, L; Ouyang, C; Tao, W; Wang, Z; Xiong, Q; Zeng, X, 2013) |
| "Human breast cancer tissues, as well as normal tissues from the same patients, were treated with clotrimazole (CTZ) and have their capacities for glucose consumption and lactate production evaluated." | 7.77 | Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues. ( Calaça, Ide C; Celestrini, Dde M; Coelho, RG; Correia, AH; Costa, MA; Sola-Penna, M, 2011) |
| " Two important determinants in this environment are hypoxia and lactic acidosis." | 7.74 | The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008) |
| "The effects of 17 beta-estradiol treatment versus tamoxifen on the metabolism of human breast cancer T47D-clone 11 cells were studied by noninvasive 31P and 13C nuclear magnetic resonance techniques." | 7.67 | Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy. ( Degani, H; Neeman, M, 1989) |
| " The current research attempted to develop poly (lactic-co-glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design." | 5.91 | Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application. ( Gandhi, S; Kavisri, M; Maddiboyina, B; Moovendhan, M; Nakkala, RK; Roy, H, 2023) |
| "Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis." | 5.56 | Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020) |
| "Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation." | 5.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)." | 5.46 | Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017) |
| "Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types." | 5.46 | l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017) |
| "P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut." | 5.43 | Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. ( Domb, AJ; Katiyar, SS; Khan, W; Muntimadugu, E; Rafeeqi, TA, 2016) |
| "Chrysin is a natural flavonoid which has been reported to have some significant biological effects on the processes of chemical defense, nitrogen fixation, inflammation, and oxidation." | 5.43 | Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. ( Akbarzadeh, A; Anari, E; Zarghami, N, 2016) |
| "In our current studies, using breast cancer cell lines, we determined the protective role of OA in high salt-mediated osmotic stress-induced cancer growth." | 5.43 | Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. ( Amara, S; Tiriveedhi, V; Zheng, M, 2016) |
| "Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity." | 5.43 | Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer. ( Dai, Z; Du, Y; Jing, L; Li, X; Li, Y; Liang, X; Tian, J; Zhang, Q, 2016) |
| "Breast cancer is the most common cancer in women worldwide." | 5.42 | Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. ( Koyakutty, M; Menon, D; Mony, U; Narayanan, S; Paul-Prasanth, B; Vijaykumar, DK, 2015) |
| " PLGA nanoparticles proved to be completely safe, suggesting a potential utilization of this nanocomplex to improve the intrinsically poor bioavailability of curcumin for the treatment of severe malignant breast cancer." | 5.39 | Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. ( Bonetti, P; Colombo, M; Pandolfi, L; Prosperi, D; Verderio, P, 2013) |
| "Perifosine is an anticancer alkylphospholipid used in clinical trials." | 5.38 | Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012) |
| "Our results showed that the three breast cancer cell lines used presented different sensitivities to 3-BP: ZR-75-1 ER (+)>MCF-7 ER (+)>SK-BR-3 ER (-)." | 5.38 | Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. ( Azevedo-Silva, J; Baltazar, F; Casal, M; Ko, YH; Moreira, R; Pacheco, A; Pedersen, PL; Pedro, M; Pinheiro, C; Preto, A; Queirós, O, 2012) |
| "Biopsies from breast cancer patients (n=98) were excised during surgery and analyzed by high-resolution magic angle spinning MRS." | 5.38 | Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers. ( Bathen, TF; Buydens, LM; Fjøsne, HE; Giskeødegård, GF; Gribbestad, IS; Lundgren, S; Postma, G; Sitter, B, 2012) |
| "Clotrimazole is an anti-fungal azole derivative recently recognized as a calmodulin antagonist with promising anti-cancer effect." | 5.33 | Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. ( Da Poian, AT; de Freitas, MS; Holandino, C; Marinho-Carvalho, MM; Meira, DD; Sola-Penna, M; Teixeira, CA; Veiga, VF, 2005) |
| "In the present study, we synthesized a novel nanostructure for the co-delivery of curcumin and siRNA to breast cancer cells." | 4.12 | Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles. ( Azedi, F; Bayandori, M; Hamblin, MR; Hasanzadeh, A; Heidari, E; Karimi, M; Mohammad Gholinia Sarpoli, L; Zare-Karizi, S, 2022) |
| "In this study, we generated and characterized hyaluronate-PEG-Chitosan-Lactate (H-PCL) nanoparticles (NPs) to simultaneously deliver IL6-specific siRNA and BV6 to 4T1 (breast cancer) and CT26 (colon cancer) cells, and investigate the anti-tumor properties of this combination therapy both in vitro and in vivo." | 3.96 | Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression. ( Ahmadi, A; Boroumand-Noughabi, S; Hassannia, H; Heydari, M; Hojjat-Farsangi, M; Izadi, S; Jadidi-Niaragh, F; Karoon Kiani, F; Keramati, MR; Masjedi, A; Mohammadi, H; Sadat Eshaghi, F; Salimifard, S; Shahdadnejad, K, 2020) |
| " Subsequently, we examined the effects of CYC1 on proliferation, glycolysis and chemosensitivity to paclitaxel, which is one of the most common chemotherapeutic agents in breast cancer, in ER-positive breast carcinoma cells (MCF7 and T47D)." | 3.91 | Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma. ( Hara, M; Ishida, T; Miki, Y; Sasano, H; Sato, A; Suzuki, T; Takagi, K; Yoshimura, A, 2019) |
| " Cotreatment with GPR119 agonist (MBX-2982 or GSK1292263) significantly potentiated gefitinib-induced cell growth inhibition in gefitinib-insensitive MCF-7 and MDA-MB-231 breast cancer cells." | 3.88 | GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy. ( An, YJ; Choi, SY; Im, JH; Jeong, BH; Kang, KW; Kim, SY; Kim, YG; Lee, JS; Park, S, 2018) |
| " In the present study, we evaluated the efficacy of CD73-specific siRNA-loaded chitosan-lactate nanoparticles (ChLa NPs) in combination with tumor lysate pulsed dendritic cells (DCs) vaccine in treatment of 4T1 (murine derived) breast cancer bearing mice." | 3.85 | CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. ( Ajami, M; Arab, S; Atyabi, F; Habibi, S; Hadjati, J; Hassannia, H; Jadidi-Niaragh, F; Kheshtchin, N; Masoumi, F; Mirsanei, Z; Noorbakhsh, F; Rastegari, A; Shokri, F, 2017) |
| " The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer." | 3.83 | Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer. ( Mukerjee, A; Ranjan, AP; Vishwanatha, JK, 2016) |
| "In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells." | 3.83 | A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR. ( Akbarzadeh, A; Barkhordari, A; Ghasemali, S; Kordi, S; Rahmati, YM; Tozihi, M; Zarghami, N, 2016) |
| "A folate-receptor-targeted poly (lactide-co-Glycolide) (PLGA)-Polyethylene glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into breast cancer cells." | 3.83 | Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations. ( Dinarvand, R; Esfandyari-Manesh, M; Faghihi, S; Fasehee, H; Ghaffari, SH; Ghavamzadeh, A; Moradian, H, 2016) |
| "Paclitaxel is a commonly used agent for breast cancer therapy, which comes across the obstacle "drug resistance", resulting in shortened overall survival of patients." | 3.83 | PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production. ( Cao, Z; Ge, X; Gu, Y; Han, M; Li, J; Lyu, P; Wang, F; Xia, W; Yu, Z, 2016) |
| "Breast cancer is believed as the second most common cause of cancer-related deaths in women for which tamoxifen is frequently prescribed." | 3.83 | Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen. ( Chitkara, D; Kumar, P; Kumar, R; Raza, K; Singh, B; Thakur, CK; Thotakura, N, 2016) |
| "This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer." | 3.81 | Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. ( Ghosh, S; Haldar, C; Maiti, P; Pandey, SK, 2015) |
| "Lapatinib (LPT) could sensitize human epidermal growth factor receptor-2 (HER-2) positive breast cancer to paclitaxel (PTX) and induce synergetic action with PTX in preclinical test and phase II/III trial." | 3.81 | A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro. ( Cao, S; Jiang, X; Wang, F; Wang, Y; Wei, Y; Xiong, Y; Xu, S; Zhang, Q; Zhang, S; Zou, A, 2015) |
| " With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release." | 3.81 | Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells. ( Chen, C; Hu, K; Li, J; Liu, J; Liu, Y; Liu, Z; Sheng, W; Tang, J; Wu, Y; Zhang, J; Zhao, Y; Zhou, H, 2015) |
| "The present study was performed to investigate the therapeutic performance of polymer-lipid hybrid nanoparticles towards the delivery of lapatinib (LPT) in breast cancers." | 3.81 | Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation. ( Huo, ZJ; Liu, K; Liu, P; Pang, B; Wang, SJ; Wang, ZQ; Zuo, WS, 2015) |
| "Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients." | 3.81 | Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. ( Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH, 2015) |
| "The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer." | 3.79 | Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013) |
| "In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation." | 3.79 | Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. ( Araújo, I; Correia-Branco, A; Costa, T; Faria, A; Keating, E; Martel, F; Moreira, L, 2013) |
| "A star-shaped biodegradable polymer, mannitol-core poly(d,l-lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (M-PLGA-TPGS), was synthesized in order to provide a novel nanoformulation for breast cancer chemotherapy." | 3.79 | Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy. ( Huang, L; Liu, T; Mei, L; Ouyang, C; Tao, W; Wang, Z; Xiong, Q; Zeng, X, 2013) |
| "Human breast cancer tissues, as well as normal tissues from the same patients, were treated with clotrimazole (CTZ) and have their capacities for glucose consumption and lactate production evaluated." | 3.77 | Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues. ( Calaça, Ide C; Celestrini, Dde M; Coelho, RG; Correia, AH; Costa, MA; Sola-Penna, M, 2011) |
| " In this study, we evaluated the effects of RGD-conjugated poly (lactic acid-co-lysine)-(Arginine-Glycine-Aspartic) nanoparticles (PLA-PLL-RGD NPs) on targeted delivery to Bacp-37 breast cancer bearing mice." | 3.77 | RGD-conjugated PLA-PLL nanoparticles targeting to Bacp-37 breast cancer xenografts in vivo. ( Duan, Y; Li, Y; Liu, P; Qi, X; Sun, Y; Wang, H, 2011) |
| "The aim of the present study was to develop nanoparticles of tamoxifen citrate, a non-steroidal antiestrogenic drug used for the treatment of breast cancer." | 3.76 | Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation. ( Basu, S; Mukherjee, B; Sahana, B; Santra, K, 2010) |
| "The aim of this work was to prepare paclitaxel-loaded PLGA nanoparticles and determine cytotoxicity of released paclitaxel for two hypoxic human tumor cell lines: breast carcinoma (MCF-7) and carcinoma cervicis (HeLa)." | 3.75 | Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells. ( Bai, L; Dou, K; Guo, G; Jin, C; Song, W; Wu, H, 2009) |
| " Two important determinants in this environment are hypoxia and lactic acidosis." | 3.74 | The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008) |
| "This paper continued our earlier work on the poly(D,L-lactide-co-glycolide)/montmorillonite nanoparticles (PLGA/MMT NPs), which were further decorated by human epidermal growth factor receptor-2 (HER2) antibody Trastuzumab for targeted breast cancer chemotherapy with paclitaxel as a model anticancer drug." | 3.74 | Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer. ( Feng, SS; Ranganathan, B; Sun, B, 2008) |
| "The purpose of this study was to compare the combination (Paclitaxel + 5-FU microspheres) with a single drug chemotherapy (Paclitaxel and 5-FU microspheres) against metastatic breast cancer cell line (MDA-MB 435 S)." | 3.72 | Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres. ( Ciftci, K; Gupte, A, 2004) |
| "In MX1 human breast cancer xenografts grown on the hind paw of thymusaplastic nude mice the effect of ifosfamide on tumor oxygenation, tumor pH and the concentration of lactic acid have been determined at mean tumor temperatures of 32 degrees C, 37 degrees C and 41 degrees C." | 3.69 | The effect of ifosfamide on tumor oxygenation at different temperatures. ( Mendoza, AS; Mentzel, M; Wiedemann, G, 1994) |
| "The effects of 17 beta-estradiol treatment versus tamoxifen on the metabolism of human breast cancer T47D-clone 11 cells were studied by noninvasive 31P and 13C nuclear magnetic resonance techniques." | 3.67 | Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy. ( Degani, H; Neeman, M, 1989) |
| "MCT4 and Cav-1 are also breast cancer prognostic biomarkers." | 2.50 | Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. ( Lisanti, MP; Martinez-Outschoorn, U; Sotgia, F, 2014) |
| " Studies on the dosage design of this new delivery system of leuprorelin are summarized." | 2.38 | [Once-a-month injectable microcapsules of leuprorelin acetate]. ( Ogawa, Y; Okada, H; Toguchi, H; Yamamoto, M, 1991) |
| "Globally, breast cancer is one of the leading causes of cancer death in women." | 1.91 | Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer. ( Liu, L; Luo, D; Wang, C; Xue, L; Zhang, S; Zhu, W, 2023) |
| " The current research attempted to develop poly (lactic-co-glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design." | 1.91 | Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application. ( Gandhi, S; Kavisri, M; Maddiboyina, B; Moovendhan, M; Nakkala, RK; Roy, H, 2023) |
| "TIGAR downregulation in breast carcinoma cells reduces tumor growth." | 1.91 | TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer. ( Bartrons, R; Birbe, RC; Caro, J; Domingo-Vidal, M; Győrffy, B; Ko, YH; Lin, Z; Martinez-Outschoorn, U; Philp, NJ; Roche, ME; Tuluc, M; Whitaker-Menezes, D, 2023) |
| "GPR81 supports breast cancer aggressiveness, and in MCF-7 cells, this occurs at least in part via DLL4." | 1.91 | Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4. ( Blasco, LP; Dmytriyeva, O; Goncalves-Alves, E; Kveiborg, M; Lundø, K; Pedersen, SF; Ponniah, M; Sandelin, A; Schwartz, TW; Severin, M; Spøhr, L; Trauelsen, M; Yao, J, 2023) |
| "The first-line treatment of metastatic breast cancer in premenopausal women relies on tamoxifen." | 1.72 | Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen-resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C ( Albustanji, S; Alhusban, AA; Hamadneh, LA; Shallan, AI, 2022) |
| "Fifty-five matched breast cancer tissues and the para-carcinoma normal tissues were included in this study and used to verify TUBA1C expression using quantitative reverse transcription-PCR and western blotting." | 1.72 | Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer. ( Fan, R; Sun, S; Wang, Z; Wu, Z, 2022) |
| "Mechanistically, breast cancer cells with ectopic Zeb1 expression produce lactate in the acidic tumor milieu to induce the alternatively activated (M2) macrophage phenotype through stimulation of the PKA/CREB signaling pathway." | 1.72 | Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer. ( Chang, A; Jiang, H; Li, J; Ou, Y; Sun, W; Wang, H; Wang, W; Wang, Z; Wei, H; Xiao, X; Yang, S; Zhao, L, 2022) |
| "Knockdown of GPR81 decreased breast cancer cell proliferation, and tumor growth." | 1.72 | The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer. ( Hata, K; Hirose, K; Ishihara, S; Nishimura, R; Okui, T; Toyosawa, S; Uzawa, N; Yoneda, T, 2022) |
| "Tamoxifen is a widely used estrogen receptor inhibitor, whose clinical success is limited by the development of acquired resistance." | 1.72 | Lactate is a potential promoter of tamoxifen resistance in MCF7 cells. ( Di Stefano, G; Farabegoli, F; Govoni, M; Rossi, V, 2022) |
| "Also, treating mice with established breast tumors (4T1) using NPs loaded with siRNA molecules in combination with DC vaccine pulsed with tumor lysate significantly inhibited tumor growth and increased survival in mice." | 1.72 | Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model. ( Afsharimanesh, N; Barshidi, A; Ebrahimi, F; Hassannia, H; Hojjat-Farsangi, M; Jadidi-Niaragh, F; Jafari, R; Jalali, P; Karpisheh, V; Kiaie, SH; Kiani, FK; Mahmoodpoor, A; Mohammadi, M; Nami, S; Navashenaq, JG; Noukabadi, FK; Zolbanin, NM, 2022) |
| "However, its role in breast cancer cell glucose metabolism was unclear." | 1.62 | Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021) |
| "Forty paired breast cancer tumor samples, the adjacent non-tumor and five healthy tissues were collected." | 1.62 | The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. ( Afkhami, H; Fathi, J; Khaledi, M; Moslemi, M; Nafissi, N; Rezaie, E; Sohrabi, E; Zekri, A, 2021) |
| "Twenty breast (58 ± 10 years) and 20 prostate cancer survivors (68 ± 6 years), 3." | 1.56 | Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO ( Rosenberger, F; Schlüter, K; Schneider, J; Sprave, T; Wiskemann, J, 2020) |
| "Hormone-dependent T-47D breast cancer cells were used." | 1.56 | Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer. ( Jeong, KY; Kim, HM; Lee, JK; Park, MH; Park, SY, 2020) |
| "Precision medicine in breast cancer demands markers sensitive to early treatment response." | 1.56 | Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy. ( Cheung, SM; He, J; Heys, SD; Husain, E; Masannat, Y; Miller, ID; Wahle, K, 2020) |
| "Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis." | 1.56 | Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020) |
| "Our group recently showed in breast cancer patients that EGFR expression is strongly correlated with high tumor uptake of the glucose analogue, 18F-fluorodeoxyglucose (FDG)." | 1.51 | EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling. ( Cho, YS; Jung, KH; Lee, EJ; Lee, JH; Lee, KH; Moon, SH; Park, JW, 2019) |
| "Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation." | 1.48 | Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018) |
| "Breast cancer is one of the major causes of death in the USA." | 1.48 | Vitamin D ( Hussain, F; Khan, ZS; Munir, MT; Rahman, SM; Santos, JM; Tarafdar, K, 2018) |
| "Three breast cancer cell lines and immunocompetent and immunodeficient mice were used to evaluate the therapeutic effects of Rp plus ω-3 PUFA treatment." | 1.48 | Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death. ( Chen, W; Chen, YQ; Feng, N; He, Z; Jiang, X; Lin, G; Tong, Y; Wang, S; Yang, Q; Zhu, S, 2018) |
| "4T1 murine breast cancer cells were transfected with shRNA plasmids directed against LDH-A (KD) or a scrambled control plasmid (NC)." | 1.48 | LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. ( Blasberg, R; Cohen, IJ; Khanin, R; Koutcher, JA; Maeda, M; Mane, M; Moroz, E; Satagopan, J; Serganova, I; Shindo, M; Vemuri, K, 2018) |
| "Paclitaxel (PTX) has been indicated for the treatment of a variety of solid tumors, whereas artesunate (ART) has been reported to have the potential for use in combination chemotherapy." | 1.46 | Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response. ( Kim, JO; Nguyen, CN; Nguyen, HT; Tran, BN; Yong, CS, 2017) |
| "Everolimus is a drug used successfully in a number of different oncology indications, but significant on-target toxicities exist." | 1.46 | Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer. ( Guthy, D; Laborde, L; McSheehy, P; Oz, F; Ristov, M; Sterker, D, 2017) |
| "The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)." | 1.46 | Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017) |
| "Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer." | 1.46 | Synthesis, characterization, and in vitro evaluation of targeted gold nanoshelled poly(d,l-lactide-co-glycolide) nanoparticles carrying anti p53 antibody as a theranostic agent for ultrasound contrast imaging and photothermal therapy. ( Du, J; Li, F; Li, H; Liu, X; Wan, C; Xu, L; Yang, H, 2017) |
| "Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types." | 1.46 | l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017) |
| "Human breast tumors contain significant amounts of stromal cells." | 1.46 | Tumor stroma interaction is mediated by monocarboxylate metabolism. ( Ackerstaff, E; Banerjee, D; Blasberg, RG; Kerrigan, JE; Koutcher, JA; Patel, BB; Serganova, IS, 2017) |
| " The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPβCD (hydroxyl propyl beta cyclodextrin) and to assess its anti-cancer activity against breast cancer cells." | 1.46 | Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles. ( Bhandi, MM; Borkar, RM; Gudem, S; Kadari, A; Kolapalli, VR; Kulhari, H; Sistla, R, 2017) |
| "A treatment concept of blocking breast cancer cell migration from interaction with SDF- 1α by using LFC131-NPs and then attacking breast cancer cells with doxorubicin might increase the efficacy of current breast cancer treatment." | 1.46 | CXCR4-targeted Nanoparticles Reduce Cell Viability, Induce Apoptosis and Inhibit SDF-1α Induced BT-549-Luc Cell Migration In Vitro. ( Chittasupho, C; Kewsuwan, P; Murakami, T, 2017) |
| "Evodiamine (EVO) is a plant-derived indolequinazoline alkaloid with potential anticancer activity." | 1.43 | Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles. ( Bao, J; Chen, F; Chen, M; He, C; Wang, L; Wang, S; Wang, Y; Zou, L, 2016) |
| " The present work is aimed to enhance the bioavailability of etoposide by co-administering it with quercetin (a P-gp inhibitor) in dual-loaded polymeric nanoparticle formulation." | 1.43 | Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. ( Fatma, S; Goswami, DG; Iqbal, Z; Negi, LM; Panda, AK; Talegaonkar, S; Tariq, M, 2016) |
| "P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut." | 1.43 | Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. ( Domb, AJ; Katiyar, SS; Khan, W; Muntimadugu, E; Rafeeqi, TA, 2016) |
| "Chrysin is a natural flavonoid which has been reported to have some significant biological effects on the processes of chemical defense, nitrogen fixation, inflammation, and oxidation." | 1.43 | Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. ( Akbarzadeh, A; Anari, E; Zarghami, N, 2016) |
| "Human breast cancer MDA-MB-231 cell and mice MDA-MB-231 xenograft model were used for in vitro and in vivo evaluation." | 1.43 | Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid). ( Chen, Y; Hong, H; Li, Y; Liu, C; Qian, J; Wang, G; Wang, P; Wang, Y; Yu, B; Yuan, Y, 2016) |
| "The uptakes of NPs in human breast cancer MCF-7 cells were evaluated by the flow cytometry and the confocal microscope." | 1.43 | Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin. ( Cai, X; Chen, H; Jia, Y; Lv, F; Nan, W; Qin, J; Xie, LQ; Yang, W; Zhang, QQ, 2016) |
| "Paclitaxel (PTX) is an effective anticancer agent used in the therapy of a wide variety of cancers." | 1.43 | Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel. ( Chuttani, K; Ghanghoria, R; Jain, NK; Mishra, AK; Tekade, RK, 2016) |
| "In our current studies, using breast cancer cell lines, we determined the protective role of OA in high salt-mediated osmotic stress-induced cancer growth." | 1.43 | Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. ( Amara, S; Tiriveedhi, V; Zheng, M, 2016) |
| "Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity." | 1.43 | Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer. ( Dai, Z; Du, Y; Jing, L; Li, X; Li, Y; Liang, X; Tian, J; Zhang, Q, 2016) |
| "T47D breast cancer cells were further evaluated for time-dependent and dose-dependent effects on (18)F-FDG uptake, lactate release, oxygen consumption rate (OCR), reactive oxygen species (ROS) production, and mitochondrial membrane potential." | 1.43 | Molecular mechanism of (18)F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism. ( Cho, YS; Choe, YS; Jung, KH; Lee, JH; Lee, KH; Moon, SH; Park, JW, 2016) |
| "Exercise decreases breast cancer risk and disease recurrence, but the underlying mechanisms are unknown." | 1.43 | Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses. ( Andersen, C; Christensen, JF; Dethlefsen, C; Hojman, P; Lillelund, C; Midtgaard, J; Pedersen, BK, 2016) |
| "Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells." | 1.43 | G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. ( Heo, K; Lee, YJ; Noh, DY; Park, KS; Park, S; Park, SA; Ryu, SH; Seo, YK; Shin, KJ; Suh, PG, 2016) |
| "Fresh breast tumors were initially used to generate tumor lysate antigens containing poly lactic-co-glycolic acid (PLGA) NP." | 1.43 | Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens. ( Biparva, P; Delirezh, N; Iranpour, S; Nejati, V; Shirian, S, 2016) |
| "A subgroup of breast cancers has several metabolic compartments." | 1.43 | TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. ( Bartrons, R; Birbe, RC; Capparelli, C; Caro, J; Curry, JM; Domingo-Vidal, M; Ko, YH; Lin, Z; Manzano, A; Martinez-Outschoorn, U; Navarro-Sabaté, À; Roche, M; Seifert, E; Tassone, P; Tuluc, M; Whitaker-Menezes, D, 2016) |
| "Saquinavir (SQV) is a US-FDA approved HIV protease inhibitor (HPI) for HIV cure." | 1.42 | Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity. ( Banerjee, S; Jain, NK; Kesharwani, P; Mehra, NK; Singh, R; Singh, S, 2015) |
| "Breast cancer is the most common cancer in women worldwide." | 1.42 | Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. ( Koyakutty, M; Menon, D; Mony, U; Narayanan, S; Paul-Prasanth, B; Vijaykumar, DK, 2015) |
| "MCT4 depletion reduced the ability of breast cancer cells to grow in a three-dimensional (3D) matrix or as multilayered spheroids." | 1.42 | Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. ( Baenke, F; Brault, C; Dankworth, B; Dubuis, S; Griffiths, B; Howell, M; Jiang, M; Mackay, A; Reis-Filho, JS; Ros, S; Saunders, B; Schulze, A; Spencer-Dene, B; Stamp, G; Weigelt, B; Zamboni, N, 2015) |
| "Cell studies using metastatic breast cancer cells demonstrated disruption of Src kinase involved in the cancer migration by albumin-dasatinib nano-shell and generation of photoactivated oxidative stress by mTHPC-PLGA nano-core." | 1.40 | A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing. ( Chandran, P; Gupta, N; Koyakutty, M; Malarvizhi, GL; Nair, S; Ramachandran, R; Retnakumari, AP, 2014) |
| "Multidrug-resistant breast cancers have limited and ineffective clinical treatment options." | 1.40 | Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model. ( Chen, Y; Fang, DL; Lei, Y; Li, HL; Ren, K; Song, XR; Xu, B; Yang, Y; Zhang, JK; Zheng, XL, 2014) |
| " Promising properties, including long-circulation time, enhanced tumor localization, interference with "multidrug" resistance effects, and environmental biodegradability, often result in an improvement of the drug bioavailability and effectiveness." | 1.40 | Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells. ( Colombo, M; Corsi, F; Gramatica, F; Marinozzi, MR; Mazzucchelli, S; Morasso, C; Pandolfi, L; Prosperi, D; Vanna, R; Verderio, P, 2014) |
| " At the same time, higher Caco-2 cell uptake revealed its potential for oral delivery, which was well corroborated with in vivo pharmacokinetics, which suggested ∼ 5-fold and ∼ 3-fold increase in oral bioavailability as compared to the free Tmx citrate and free QT, respectively." | 1.39 | Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. ( Jain, AK; Jain, S; Thanki, K, 2013) |
| "This study showed that breast cancer cells tolerate and use lactate at clinically relevant concentrations in vitro (± glucose) and in vivo." | 1.39 | Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. ( Chi, JT; Dewhirst, MW; Kennedy, KM; Landon, CD; Pizzo, S; Ribeiro, A; Richardson, R; Scarbrough, PM; Schroeder, T; Sonveaux, P; Yuan, H, 2013) |
| "The production of lactate by T47D breast cancer cells can be characterized by Michaelis-Menten-like kinetics, with K(m) = 3." | 1.39 | Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures. ( Degani, H; Frydman, L; Harris, T, 2013) |
| "Fatigue is one of the most commonly reported side effects during treatment for breast cancer and can persist following treatment completion." | 1.39 | Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors. ( Campbell, KL; Garland, SJ; Klika, RJ; McKenzie, DC; Neil, SE, 2013) |
| " PLGA nanoparticles proved to be completely safe, suggesting a potential utilization of this nanocomplex to improve the intrinsically poor bioavailability of curcumin for the treatment of severe malignant breast cancer." | 1.39 | Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. ( Bonetti, P; Colombo, M; Pandolfi, L; Prosperi, D; Verderio, P, 2013) |
| "We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells." | 1.38 | Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. ( Ackerstaff, E; Banerjee, D; Glod, JW; Koutcher, JA; Patel, BB; Rattigan, YI; Sukenick, G, 2012) |
| "Perifosine is an anticancer alkylphospholipid used in clinical trials." | 1.38 | Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012) |
| "Our results showed that the three breast cancer cell lines used presented different sensitivities to 3-BP: ZR-75-1 ER (+)>MCF-7 ER (+)>SK-BR-3 ER (-)." | 1.38 | Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. ( Azevedo-Silva, J; Baltazar, F; Casal, M; Ko, YH; Moreira, R; Pacheco, A; Pedersen, PL; Pedro, M; Pinheiro, C; Preto, A; Queirós, O, 2012) |
| "Biopsies from breast cancer patients (n=98) were excised during surgery and analyzed by high-resolution magic angle spinning MRS." | 1.38 | Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers. ( Bathen, TF; Buydens, LM; Fjøsne, HE; Giskeødegård, GF; Gribbestad, IS; Lundgren, S; Postma, G; Sitter, B, 2012) |
| "Conversely, we generated human breast cancer cells (MDA-MB-231 cells) overexpressing CDK inhibitors, namely p16(INK4A) or p21(WAF1/CIP1)." | 1.38 | CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. ( Andò, S; Capparelli, C; Chiavarina, B; Howell, A; Hulit, J; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Pestell, TG; Sotgia, F; Whitaker-Menezes, D, 2012) |
| "Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2, HMGCL and BDH1) were preferentially expressed in the tumor stroma." | 1.38 | Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. ( Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Sotgia, F; Whitaker-Menezes, D, 2012) |
| " Oral bioavailability of Tmx was increased by 3." | 1.37 | The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen. ( Godugu, C; Jain, AK; Jain, S; Singh, RP; Swarnakar, NK, 2011) |
| "Posttreated patients with breast cancer were matched with healthy women based on age, physical fitness level, and menopausal status." | 1.37 | Exercise in patients with breast cancer and healthy controls: energy substrate oxidation and blood lactate responses. ( Battaglini, CL; Evans, ES; Groff, D; Hackney, AC; Tosti, KP, 2011) |
| "Briefly, human breast cancer cells (MCF7) were cultured with lactate or ketones, and then subjected to transcriptional analysis (exon-array)." | 1.37 | Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. ( Ertel, A; Flomenberg, N; Howell, A; Knudsen, ES; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Pestell, RG; Prisco, M; Sotgia, F; Tsirigos, A; Wang, C, 2011) |
| "The human breast cancer tissues showed a close correlation between KLF4 and PFKP expression." | 1.37 | Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer. ( Jin, WJ; Kim, HE; Kim, KS; Koh, E; Moon, JS; Park, BW; Park, SH; Park, SW, 2011) |
| "Treatment with curcumin microparticles resulted in diminished vascular endothelial growth factor expression and poorly developed tumor microvessels, indicating a significant effect on tumor angiogenesis." | 1.36 | Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. ( Blum, A; Freeman, D; Ma, L; Panyam, J; Shahani, K; Swaminathan, SK, 2010) |
| "MCF-7 breast cancer cells were employed to evaluate the cellular uptake and cytotoxicity." | 1.36 | Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: effects of surfactants on particles size, characteristics and in vitro performance. ( Feng, SS; Liu, Y; Pan, J, 2010) |
| "To improve the encapsulation efficiency and oral bioavailability of vincristine sulfate (VCR), novel self-assembled dextran sulphate-PLGA hybrid nanoparticles (DPNs) were successfully developed using self-assembly and nanoprecipitation method." | 1.36 | Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition. ( Deng, Y; He, Z; Ling, G; Meng, X; Qin, Y; Sun, J; Zhang, P; Zhang, W, 2010) |
| "Similar to in vivo FdG-PET or primary breast cancers, rates of glycolysis were diverse, being higher in cells expressing both c-Myc and HIF-1alpha and lower in cell lines low or negative in both transcription factors." | 1.35 | Regulation of the Warburg effect in early-passage breast cancer cells. ( Baggett, BK; Brown, KS; Gatenby, RA; Gillies, RJ; Robey, IF; Stephen, RM, 2008) |
| "In vitro toxicity in MDA-MB-231 breast cancer cells of the surface-adsorbed and shell-incorporated doxorubicin (Dox) loaded UCA were examined at 5 MHz insonation using a pulse repetition frequency of 100 Hz at varying pressure amplitudes." | 1.35 | Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents. ( Eisenbrey, JR; Hsu, J; Huang, P; Wheatley, MA, 2009) |
| "Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity and poor bioavailability of antineoplastic drugs." | 1.35 | Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy. ( Acharya, S; Dilnawaz, F; Sahoo, SK, 2009) |
| "Co-culture of human breast carcinoma cells (MCF-7) with paclitaxel-loaded nanoparticles demonstrated that released paclitaxel retained its bioactivity to block cells in the G2/M phase of the cell cycle and effectively sensitized hypoxic MCF-7 cells to radiation with radiosensitivity shown to be dependent of radiation dose at levels of dosages studied." | 1.34 | The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells. ( Bai, L; Guo, G; Jin, C; Liu, J; Wu, H, 2007) |
| "Clotrimazole is an anti-fungal azole derivative recently recognized as a calmodulin antagonist with promising anti-cancer effect." | 1.33 | Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. ( Da Poian, AT; de Freitas, MS; Holandino, C; Marinho-Carvalho, MM; Meira, DD; Sola-Penna, M; Teixeira, CA; Veiga, VF, 2005) |
| "Gemcitabine was infused into a central reservoir." | 1.33 | Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens. ( Brundage, RC; Elmquist, WF; Guire, DE; Kirstein, MN; Marker, PH; Remmel, RP; Yee, D, 2006) |
| "The observed dependence of breast cancer cells on pentose phosphate pathway activity and glutamine consumption for estradiol-stimulated biosynthesis suggests that these pathways may be targets for estrogen-independent breast cancer therapies." | 1.33 | Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. ( Blanch, HW; Clark, DS; Forbes, NS; Meadows, AL, 2006) |
| "Therefore, human breast cancer presents metabolic microregions." | 1.32 | Metabolism of the microregions of human breast cancer. ( Borges, JB; Curi, R; de Almeida, DC; dos Santos, MA, 2004) |
| "This method was applied in MCF7 human breast cancer implanted in the mammary gland of female CD1-NU mice and was further employed to assess tumor response to hormonal manipulation with the antiestrogen tamoxifen." | 1.31 | Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS. ( Degani, H; Margalit, R; Rivenzon-Segal, D, 2002) |
| "Metastatic breast cancer cells from pleural effusions were up to 200-fold more active in acidifying their extracellular milieu than non-malignant mammary cells cultured in the same conditions, strongly suggesting that this difference also occurs in vivo." | 1.30 | Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. ( Bird, I; Farnoud, R; Montcourrier, P; Rochefort, H; Silver, I, 1997) |
| "In MCF-7 human breast cancer cells, both TCDD and TPA inhibited constitutive and 17 beta-estradiol-induced cell proliferation but showed no apparent interactive effects." | 1.29 | Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. ( Krishnan, V; Moore, M; Narasimhan, TR; Safe, S; Scott, AI; Wang, X; Williams, HJ, 1993) |
| "For the treatment of malignant pleural effusions, we prepared doxorubicin hydrochloride (Adriamycin)-containing poly(L-lactic acid) microspheres (ADR-MS)." | 1.28 | Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres. ( Hitomi, S; Ikada, Y; Ike, O; Shimizu, Y; Wada, R, 1991) |
| "and/or "tissue-isolated" human breast cancer xenografts in T-cell-deficient rnu/rnu rats." | 1.27 | Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. ( Baessler, KH; Berg, G; Fortmeyer, HP; Kallinowski, F; Mueller-Klieser, W; Runkel, S; Vaupel, P; Wagner, K; Walenta, S, 1988) |
| "The glucose uptake rate of human mammary carcinomas transplanted into nude rats is comparable to values obtained in isotransplanted rodent tumors." | 1.27 | Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo. ( Baessler, KH; Davel, S; Kallinowskil, F; Vaupell, P; Wagner, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.30) | 18.7374 |
| 1990's | 7 (2.27) | 18.2507 |
| 2000's | 36 (11.69) | 29.6817 |
| 2010's | 216 (70.13) | 24.3611 |
| 2020's | 45 (14.61) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 4 |
| Davis, T | 1 |
| Kazerouni, AS | 1 |
| Chen, YI | 1 |
| Bloom, MJ | 1 |
| Yeh, HC | 1 |
| Yankeelov, TE | 1 |
| Virostko, J | 1 |
| Alhusban, AA | 2 |
| Hamadneh, LA | 1 |
| Albustanji, S | 2 |
| Shallan, AI | 1 |
| Karoon Kiani, F | 3 |
| Izadi, S | 2 |
| Ansari Dezfouli, E | 1 |
| Ebrahimi, F | 2 |
| Mohammadi, M | 2 |
| Chalajour, H | 1 |
| Mortazavi Bulus, M | 1 |
| Nasr Esfahani, M | 1 |
| Karpisheh, V | 2 |
| Mahmoud Salehi Khesht, A | 1 |
| Abbaszadeh-Goudarzi, K | 1 |
| Soleimani, A | 1 |
| Gholizadeh Navashenaq, J | 1 |
| Ahmadi, M | 1 |
| Hassannia, H | 6 |
| Hojjat-Farsangi, M | 4 |
| Shahmohammadi Farid, S | 1 |
| Hashemi, V | 1 |
| Jadidi-Niaragh, F | 6 |
| Wu, Z | 2 |
| Sun, S | 1 |
| Fan, R | 1 |
| Wang, Z | 8 |
| Hao, Q | 1 |
| Huang, Z | 2 |
| Li, Q | 3 |
| Liu, D | 1 |
| Wang, P | 2 |
| Wang, K | 1 |
| Li, J | 6 |
| Cao, W | 1 |
| Deng, W | 1 |
| Wu, K | 1 |
| Su, R | 1 |
| Liu, Z | 4 |
| Vadgama, J | 1 |
| Wu, Y | 2 |
| Jiang, H | 1 |
| Wei, H | 1 |
| Wang, H | 7 |
| Ou, Y | 1 |
| Xiao, X | 1 |
| Wang, W | 2 |
| Chang, A | 1 |
| Sun, W | 1 |
| Zhao, L | 1 |
| Yang, S | 1 |
| Chen, W | 2 |
| Hou, R | 1 |
| Liang, H | 2 |
| Zhang, Y | 6 |
| Yang, Y | 4 |
| Li, H | 6 |
| Li, X | 2 |
| Zhang, Q | 5 |
| Li, K | 1 |
| Qiu, Y | 1 |
| Ishihara, S | 1 |
| Hata, K | 1 |
| Hirose, K | 1 |
| Okui, T | 1 |
| Toyosawa, S | 1 |
| Uzawa, N | 1 |
| Nishimura, R | 1 |
| Yoneda, T | 1 |
| Zhou, J | 2 |
| Yin, Q | 1 |
| Li, S | 2 |
| Yang, R | 1 |
| Lou, R | 1 |
| Sun, Y | 3 |
| Du, B | 1 |
| Rossi, V | 1 |
| Govoni, M | 1 |
| Farabegoli, F | 1 |
| Di Stefano, G | 1 |
| Bhatt, K | 1 |
| Patil, P | 1 |
| Jani, P | 1 |
| Thakkar, P | 1 |
| Sawant, K | 1 |
| Barshidi, A | 1 |
| Noukabadi, FK | 1 |
| Kiani, FK | 1 |
| Afsharimanesh, N | 1 |
| Kiaie, SH | 1 |
| Navashenaq, JG | 1 |
| Zolbanin, NM | 1 |
| Mahmoodpoor, A | 1 |
| Nami, S | 1 |
| Jalali, P | 1 |
| Jafari, R | 1 |
| Jin, L | 1 |
| Guo, Y | 2 |
| Chen, J | 2 |
| Wen, Z | 1 |
| Jiang, Y | 1 |
| Qian, J | 2 |
| Mohammad Gholinia Sarpoli, L | 1 |
| Zare-Karizi, S | 1 |
| Heidari, E | 1 |
| Hasanzadeh, A | 1 |
| Bayandori, M | 1 |
| Azedi, F | 1 |
| Hamblin, MR | 1 |
| Karimi, M | 1 |
| Wang, C | 5 |
| Xue, L | 1 |
| Zhu, W | 2 |
| Liu, L | 2 |
| Zhang, S | 3 |
| Luo, D | 2 |
| Maddiboyina, B | 1 |
| Roy, H | 1 |
| Nakkala, RK | 1 |
| Gandhi, S | 1 |
| Kavisri, M | 1 |
| Moovendhan, M | 1 |
| Passeri, G | 1 |
| Northcote-Smith, J | 1 |
| Suntharalingam, K | 1 |
| Roche, ME | 1 |
| Ko, YH | 4 |
| Domingo-Vidal, M | 2 |
| Lin, Z | 9 |
| Whitaker-Menezes, D | 11 |
| Birbe, RC | 2 |
| Tuluc, M | 2 |
| Győrffy, B | 1 |
| Caro, J | 2 |
| Philp, NJ | 2 |
| Bartrons, R | 2 |
| Martinez-Outschoorn, U | 4 |
| Arponen, O | 1 |
| Wodtke, P | 1 |
| Gallagher, FA | 1 |
| Woitek, R | 1 |
| Carver, GE | 1 |
| Locknar, SA | 1 |
| Ghule, PN | 1 |
| Pung, CJ | 1 |
| Weaver, DL | 1 |
| Stein, JL | 1 |
| Stein, GS | 1 |
| Frisardi, V | 1 |
| Canovi, S | 1 |
| Vaccaro, S | 1 |
| Frazzi, R | 1 |
| Deng, J | 1 |
| Liao, X | 1 |
| Lundø, K | 2 |
| Dmytriyeva, O | 1 |
| Spøhr, L | 1 |
| Goncalves-Alves, E | 1 |
| Yao, J | 1 |
| Blasco, LP | 1 |
| Trauelsen, M | 2 |
| Ponniah, M | 1 |
| Severin, M | 1 |
| Sandelin, A | 1 |
| Kveiborg, M | 1 |
| Schwartz, TW | 2 |
| Pedersen, SF | 2 |
| Khajah, MA | 1 |
| Khushaish, S | 1 |
| Luqmani, YA | 1 |
| Raychaudhuri, D | 1 |
| Bhattacharya, R | 1 |
| Sinha, BP | 1 |
| Liu, CSC | 1 |
| Ghosh, AR | 1 |
| Rahaman, O | 1 |
| Bandopadhyay, P | 1 |
| Sarif, J | 1 |
| D'Rozario, R | 1 |
| Paul, S | 1 |
| Das, A | 1 |
| Sarkar, DK | 1 |
| Chattopadhyay, S | 1 |
| Ganguly, D | 1 |
| Jung, KH | 2 |
| Lee, EJ | 1 |
| Park, JW | 2 |
| Lee, JH | 2 |
| Moon, SH | 2 |
| Cho, YS | 2 |
| Lee, KH | 2 |
| Schlüter, K | 2 |
| Schneider, J | 2 |
| Sprave, T | 2 |
| Wiskemann, J | 2 |
| Rosenberger, F | 2 |
| Tahtouh, R | 1 |
| Wardi, L | 1 |
| Sarkis, R | 1 |
| Hachem, R | 1 |
| Raad, I | 1 |
| El Zein, N | 1 |
| Hilal, G | 1 |
| Brown, TP | 1 |
| Bhattacharjee, P | 1 |
| Ramachandran, S | 1 |
| Sivaprakasam, S | 1 |
| Ristic, B | 1 |
| Sikder, MOF | 1 |
| Ganapathy, V | 1 |
| Park, SY | 1 |
| Lee, JK | 1 |
| Park, MH | 1 |
| Jeong, KY | 1 |
| Kim, HM | 1 |
| Cheung, SM | 1 |
| Husain, E | 1 |
| Masannat, Y | 1 |
| Miller, ID | 1 |
| Wahle, K | 1 |
| Heys, SD | 1 |
| He, J | 2 |
| Becker, LM | 1 |
| O'Connell, JT | 1 |
| Vo, AP | 1 |
| Cain, MP | 1 |
| Tampe, D | 1 |
| Bizarro, L | 1 |
| Sugimoto, H | 1 |
| McGow, AK | 1 |
| Asara, JM | 1 |
| Lovisa, S | 1 |
| McAndrews, KM | 1 |
| Zielinski, R | 1 |
| Lorenzi, PL | 1 |
| Zeisberg, M | 1 |
| Raza, S | 1 |
| LeBleu, VS | 1 |
| Kalluri, R | 1 |
| Masjedi, A | 2 |
| Ahmadi, A | 2 |
| Ghani, S | 1 |
| Malakotikhah, F | 1 |
| Nabi Afjadi, M | 1 |
| Irandoust, M | 1 |
| Heydarzadeh Asl, S | 1 |
| Atyabi, F | 4 |
| Namdar, A | 1 |
| Ghalamfarsa, G | 1 |
| Tang, J | 2 |
| Meka, AK | 1 |
| Theivendran, S | 1 |
| Wang, Y | 11 |
| Song, H | 1 |
| Fu, J | 1 |
| Ban, W | 1 |
| Gu, Z | 1 |
| Lei, C | 1 |
| Yu, C | 1 |
| Salimifard, S | 1 |
| Sadat Eshaghi, F | 1 |
| Shahdadnejad, K | 1 |
| Heydari, M | 1 |
| Mohammadi, H | 1 |
| Boroumand-Noughabi, S | 1 |
| Keramati, MR | 1 |
| Hillis, AL | 1 |
| Toker, A | 1 |
| Park, JM | 1 |
| Reed, GD | 1 |
| Liticker, J | 1 |
| Putnam, WC | 1 |
| Chandra, A | 1 |
| Yaros, K | 1 |
| Afzal, A | 1 |
| MacNamara, J | 1 |
| Raza, J | 1 |
| Hall, RG | 1 |
| Baxter, J | 1 |
| Derner, K | 1 |
| Pena, S | 1 |
| Kallem, RR | 1 |
| Subramaniyan, I | 1 |
| Edpuganti, V | 1 |
| Harrison, CE | 1 |
| Muthukumar, A | 1 |
| Lewis, C | 1 |
| Reddy, S | 1 |
| Unni, N | 1 |
| Klemow, D | 1 |
| Syed, S | 1 |
| Cole, S | 1 |
| Froehlich, T | 1 |
| Ayers, C | 1 |
| de Lemos, J | 1 |
| Malloy, CR | 1 |
| Haley, B | 1 |
| Zaha, VG | 1 |
| Kim, NH | 1 |
| Sung, NJ | 1 |
| Youn, HS | 1 |
| Park, SA | 2 |
| Gao, J | 4 |
| Guo, Z | 1 |
| Cheng, J | 1 |
| Sun, B | 2 |
| Wu, S | 1 |
| Dong, F | 1 |
| Yan, X | 2 |
| Kalezic, A | 1 |
| Udicki, M | 1 |
| Srdic Galic, B | 1 |
| Aleksic, M | 1 |
| Korac, A | 1 |
| Jankovic, A | 1 |
| Korac, B | 1 |
| Fan, Y | 1 |
| Wang, J | 2 |
| Xu, Y | 5 |
| Song, T | 1 |
| Liang, X | 4 |
| Jin, F | 1 |
| Su, D | 1 |
| Keibler, MA | 1 |
| Dong, W | 1 |
| Korthauer, KD | 1 |
| Hosios, AM | 1 |
| Moon, SJ | 1 |
| Sullivan, LB | 1 |
| Liu, N | 1 |
| Abbott, KL | 1 |
| Arevalo, OD | 1 |
| Ho, K | 1 |
| Lee, J | 1 |
| Phanse, AS | 1 |
| Kelleher, JK | 1 |
| Iliopoulos, O | 1 |
| Coloff, JL | 1 |
| Vander Heiden, MG | 1 |
| Stephanopoulos, G | 1 |
| Hamadneh, L | 1 |
| Al-Lakkis, L | 1 |
| Tarawneh, S | 1 |
| Abu-Irmaileh, B | 1 |
| Al-Bawab, AQ | 1 |
| Sohrabi, E | 1 |
| Moslemi, M | 1 |
| Rezaie, E | 1 |
| Nafissi, N | 1 |
| Khaledi, M | 1 |
| Afkhami, H | 1 |
| Fathi, J | 1 |
| Zekri, A | 1 |
| Murphy, DA | 1 |
| Cheng, H | 1 |
| Yang, T | 1 |
| Adjei, IM | 1 |
| Huang, SL | 1 |
| Huang, ZC | 1 |
| Zhang, CJ | 1 |
| Xie, J | 1 |
| Lei, SS | 1 |
| Wu, YQ | 1 |
| Fan, PZ | 1 |
| Mack, N | 1 |
| Mazzio, EA | 1 |
| Bauer, D | 1 |
| Flores-Rozas, H | 1 |
| Soliman, KF | 1 |
| Zhang, J | 5 |
| Wusiman, Z | 1 |
| Yin, Y | 2 |
| Shen, Q | 1 |
| Shavi, GV | 1 |
| Nayak, UY | 1 |
| Reddy, MS | 1 |
| Ginjupalli, K | 1 |
| Deshpande, PB | 1 |
| Averineni, RK | 1 |
| Udupa, N | 1 |
| Sadhu, SS | 1 |
| Danilenkoff, C | 1 |
| Raghavendra, R | 1 |
| Grill, AE | 1 |
| Shahani, K | 2 |
| Koniar, B | 1 |
| Panyam, J | 2 |
| Li, L | 3 |
| Kang, L | 1 |
| Zhao, W | 1 |
| Feng, Y | 1 |
| Liu, W | 2 |
| Wang, T | 1 |
| Mai, H | 1 |
| Huang, J | 3 |
| Chen, S | 1 |
| Liang, Y | 2 |
| Han, J | 2 |
| Xu, X | 1 |
| Ye, Q | 1 |
| Jiang, SF | 1 |
| Tu, KL | 1 |
| Zhou, L | 1 |
| Fu, Q | 2 |
| Zhao, YH | 2 |
| Tran, BN | 1 |
| Nguyen, HT | 1 |
| Kim, JO | 1 |
| Yong, CS | 1 |
| Nguyen, CN | 1 |
| Laborde, L | 1 |
| Oz, F | 1 |
| Ristov, M | 1 |
| Guthy, D | 1 |
| Sterker, D | 1 |
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| Majd, S | 1 |
| Khan, MN | 1 |
| Haggag, YA | 1 |
| Lane, ME | 1 |
| McCarron, PA | 1 |
| Tambuwala, MM | 1 |
| Wan, CF | 1 |
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| Dong, Q | 1 |
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| Yang, H | 4 |
| Li, FH | 2 |
| Belz, JE | 1 |
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| Baldwin, P | 1 |
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| van de Ven, AL | 1 |
| Liby, KT | 1 |
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| Mathur, P | 1 |
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| Khan, ZS | 1 |
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| Rahman, SM | 1 |
| Hussain, F | 1 |
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| Tao, C | 1 |
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| Yu, F | 1 |
| Zhang, H | 5 |
| Wang, D | 3 |
| Chen, Y | 6 |
| Zhang, G | 3 |
| Zhou, G | 2 |
| Liu, J | 7 |
| Sun, Z | 4 |
| Sun, D | 2 |
| Zou, H | 1 |
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| Lu, Y | 3 |
| Zhong, Y | 3 |
| Xue, M | 1 |
| Ji, X | 1 |
| Liu, Y | 6 |
| Wang, B | 2 |
| Sun, L | 2 |
| Li, W | 1 |
| Sahin, A | 1 |
| Spiroux, F | 1 |
| Guedon, I | 1 |
| Arslan, FB | 1 |
| Sarcan, ET | 1 |
| Ozkan, T | 1 |
| Colak, N | 1 |
| Yuksel, S | 1 |
| Ozdemir, S | 1 |
| Ozdemir, B | 1 |
| Akbas, S | 1 |
| Ultav, G | 1 |
| Aktas, Y | 1 |
| Capan, Y | 1 |
| Akinyelu, J | 1 |
| Singh, M | 1 |
| Lee, SJ | 2 |
| Kim, HJ | 1 |
| Huh, YM | 1 |
| Kim, IW | 1 |
| Jeong, JH | 1 |
| Kim, JC | 1 |
| Kim, JD | 1 |
| Loya-Castro, MF | 1 |
| Sánchez-Mejía, M | 1 |
| Sánchez-Ramírez, DR | 1 |
| Domínguez-Ríos, R | 1 |
| Escareño, N | 1 |
| Oceguera-Basurto, PE | 1 |
| Figueroa-Ochoa, ÉB | 1 |
| Quintero, A | 1 |
| Del Toro-Arreola, A | 1 |
| Topete, A | 1 |
| Daneri-Navarro, A | 1 |
| Mu, X | 1 |
| Shi, W | 1 |
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| Zhao, T | 1 |
| Geng, B | 1 |
| Pan, J | 3 |
| Hu, S | 1 |
| Zhang, C | 3 |
| Shen, J | 1 |
| Che, Y | 1 |
| Lv, Y | 1 |
| Wen, H | 1 |
| You, Q | 1 |
| Colzani, B | 1 |
| Pandolfi, L | 3 |
| Hoti, A | 1 |
| Iovene, PA | 1 |
| Natalello, A | 1 |
| Avvakumova, S | 1 |
| Colombo, M | 3 |
| Prosperi, D | 3 |
| Li, XY | 1 |
| Hu, H | 1 |
| Xu, L | 4 |
| Yang, SP | 1 |
| Hagar, A | 1 |
| Flynn, S | 1 |
| Patterson, K | 1 |
| Haddad, F | 1 |
| Wan, C | 2 |
| Xie, S | 1 |
| Li, F | 2 |
| Huang, Q | 1 |
| Cai, T | 1 |
| Huang, Y | 2 |
| Liu, Q | 2 |
| Xia, X | 1 |
| Wang, Q | 1 |
| Whitney, JCC | 1 |
| Cole, SPC | 1 |
| Cai, Y | 1 |
| Noor, SI | 1 |
| Jamali, S | 2 |
| Ames, S | 2 |
| Langer, S | 1 |
| Deitmer, JW | 2 |
| Becker, HM | 2 |
| Liu, X | 3 |
| Montissol, S | 1 |
| Uber, A | 1 |
| Ganley, S | 1 |
| Grossestreuer, AV | 1 |
| Berg, K | 1 |
| Heydrick, S | 1 |
| Donnino, MW | 1 |
| Pan, A | 1 |
| Chen, B | 1 |
| Dai, W | 1 |
| He, B | 1 |
| Wang, X | 6 |
| Eastlack, SC | 1 |
| Dong, S | 1 |
| Ivan, C | 1 |
| Alahari, SK | 1 |
| Long, Y | 1 |
| Gao, Z | 1 |
| Hu, X | 1 |
| Xiang, F | 1 |
| Han, X | 1 |
| Yin, L | 1 |
| Qin, J | 2 |
| Lan, L | 1 |
| Yin, F | 1 |
| Zhu, S | 1 |
| Feng, N | 1 |
| Lin, G | 1 |
| Tong, Y | 1 |
| Jiang, X | 2 |
| Yang, Q | 1 |
| Wang, S | 2 |
| He, Z | 3 |
| Chen, YQ | 1 |
| Castagnoli, L | 1 |
| Iorio, E | 1 |
| Dugo, M | 1 |
| Koschorke, A | 1 |
| Faraci, S | 1 |
| Canese, R | 1 |
| Casalini, P | 1 |
| Nanni, P | 1 |
| Vernieri, C | 1 |
| Di Nicola, M | 1 |
| Morelli, D | 1 |
| Tagliabue, E | 1 |
| Pupa, SM | 1 |
| Serganova, I | 2 |
| Cohen, IJ | 1 |
| Vemuri, K | 1 |
| Shindo, M | 1 |
| Maeda, M | 1 |
| Mane, M | 1 |
| Moroz, E | 1 |
| Khanin, R | 2 |
| Satagopan, J | 1 |
| Koutcher, JA | 4 |
| Blasberg, R | 2 |
| Im, JH | 1 |
| Kang, KW | 2 |
| Kim, SY | 1 |
| Kim, YG | 1 |
| An, YJ | 1 |
| Park, S | 3 |
| Jeong, BH | 1 |
| Choi, SY | 1 |
| Lee, JS | 1 |
| Türkcan, S | 1 |
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| Pratx, G | 2 |
| Guan, X | 1 |
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| Hoffmann, P | 1 |
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| von Lueder, T | 1 |
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| Sengupta, D | 1 |
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| von Eyben, R | 1 |
| Abbyad, P | 1 |
| Chen, F | 2 |
| Yang, L | 4 |
| Zhang, X | 2 |
| Tu, Q | 1 |
| Yin, D | 1 |
| Lin, D | 1 |
| Wong, PP | 1 |
| Huang, D | 1 |
| Xing, Y | 1 |
| Zhao, J | 2 |
| Li, M | 1 |
| Su, F | 1 |
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| Song, E | 1 |
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| Hemmati, S | 1 |
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| Brodsky, AN | 1 |
| Odenwelder, DC | 1 |
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| Ortabaeva, DR | 1 |
| Petrov, AN | 1 |
| Silva, C | 1 |
| Correia-Branco, A | 3 |
| Andrade, N | 1 |
| Ferreira, AC | 1 |
| Soares, ML | 1 |
| Sonveaux, P | 4 |
| Stephenne, J | 1 |
| Martel, F | 4 |
| Bharali, DJ | 2 |
| Yalcin, M | 2 |
| Davis, PJ | 2 |
| Mousa, SA | 2 |
| Li, Z | 2 |
| Liu, K | 2 |
| Sun, P | 1 |
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| Hao, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy[NCT04679233] | 0 participants (Actual) | Interventional | 2021-02-28 | Withdrawn (stopped due to PI has withdrawn from the program, the study never started.) | |||
| Clinical and Functional Variables in the Assessment of Oncology Patient[NCT03879096] | 120 participants (Actual) | Interventional | 2016-05-01 | Completed | |||
| Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284] | Phase 2 | 40 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Feasibility of Monitoring of Bone Free Flaps With Microdialysis Catheter Directly Positioned in Bone Tissue[NCT01879384] | 34 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for lactic acid and Breast Neoplasms
| Article | Year |
|---|---|
Hyperpolarised
Topics: Breast; Breast Neoplasms; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Pyruvic Acid | 2023 |
The Significance of Microenvironmental and Circulating Lactate in Breast Cancer.
Topics: Breast Neoplasms; Female; Glucose; Glycolysis; Humans; Lactic Acid | 2023 |
Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.
Topics: Animals; Autophagy; Breast Neoplasms; Cachexia; Carcinoma; Caveolin 1; Cell Line, Tumor; Cell Transf | 2014 |
Effect of polyphenols on glucose and lactate transport by breast cancer cells.
Topics: Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expres | 2016 |
Predicting tumour response to anti-HER1 therapy using medical imaging: a literature review and in vitro study of [18F]-FDG incorporation by breast cancer cells responding to cetuximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; | 2011 |
[Once-a-month injectable microcapsules of leuprorelin acetate].
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Capsules; Delayed-Action Preparations; Drug Delivery | 1991 |
2 trials available for lactic acid and Breast Neoplasms
| Article | Year |
|---|---|
[Therapeutic evaluation of the polylactic acid gel (PLA-G) used for preventing skin flap adhesion in modified radical mastectomy].
Topics: Breast Neoplasms; Drainage; Female; Gels; Humans; Lactic Acid; Mastectomy, Modified Radical; Necrosi | 2013 |
Aerobic exercise intensity in breast cancer patients: a preliminary investigation.
Topics: Adult; Breast Neoplasms; Case-Control Studies; Exercise; Exercise Test; Female; Heart Rate; Humans; | 2009 |
300 other studies available for lactic acid and Breast Neoplasms
| Article | Year |
|---|---|
Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Fluorescence Resonance Energy Transfer; Glucose; Humans; | 2022 |
Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen-resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C
Topics: Breast Neoplasms; Electric Conductivity; Electrophoresis, Capillary; Female; Gene Expression; Glucos | 2022 |
Simultaneous silencing of the A2aR and PD-1 immune checkpoints by siRNA-loaded nanoparticles enhances the immunotherapeutic potential of dendritic cell vaccine in tumor experimental models.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Chitosan; Colorectal Neoplasms; Combined M | 2022 |
Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.
Topics: Adenosine Triphosphate; Adult; Aged; Animals; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell P | 2022 |
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea | 2022 |
Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Lactic Acid; Macrophages; Phosphatid | 2022 |
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine; | 2022 |
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
Topics: Breast Neoplasms; Calcineurin; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hypoxia; Lactic | 2022 |
The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer.
Topics: Breast Neoplasms; Female; Glycolysis; Humans; Lactic Acid; Receptors, G-Protein-Coupled; Tumor Micro | 2022 |
A deep tumor penetration nanoplatform for glycolysis inhibition and antimetastasis of breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Edetic Acid; Female; Folic Acid; Glycolysis; Humans; Indocyanine | 2022 |
Lactate is a potential promoter of tamoxifen resistance in MCF7 cells.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Lactic | 2022 |
Design and evaluation of hyaluronic acid-coated PLGA nanoparticles of raloxifene hydrochloride for treatment of breast cancer.
Topics: Breast Neoplasms; Drug Carriers; Female; Humans; Hyaluronic Acid; Lactic Acid; Nanoparticles; Partic | 2021 |
Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model.
Topics: Animals; Antigens, CD; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Dendritic Cells; Immune | 2022 |
Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Energy Metabolism; Female; Glycolysis; Hu | 2022 |
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Emulsions; Femal | 2022 |
Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer.
Topics: Breast Neoplasms; Female; Glycolysis; Humans; Lactic Acid; Macrophage Activation; Macrophages | 2023 |
Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application.
Topics: Breast Neoplasms; Drug Carriers; Female; Humans; Lactic Acid; Nanoparticles; Particle Size; Polyglyc | 2023 |
Payload Release Profile and Anti-Cancer Stem Cell Properties of Compositionally Different Polymeric Nanoparticles Containing a Copper(II) Complex.
Topics: Breast Neoplasms; Copper; Drug Carriers; Female; Humans; Lactic Acid; Nanoparticles; Neoplasm Recurr | 2023 |
TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Female; Gly | 2023 |
Multispectral Imaging of Metabolic Fluorophores: Comparing In Vivo and Fresh Ex Vivo Tissue.
Topics: Animals; Breast Neoplasms; Female; Flavin-Adenine Dinucleotide; Humans; Lactic Acid; Mice; NAD | 2024 |
Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer.
Topics: Breast Neoplasms; Female; Histones; Humans; Immunotherapy; Lactic Acid; Lysine; Neoplasms; Prognosis | 2023 |
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4.
Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Calcium-Binding Proteins; Female; Humans; La | 2023 |
The effect of lactate dehydrogenase inhibitors on proliferation, motility and invasion of breast cancer cells
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; L-Lactate Deh | 2024 |
Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells.
Topics: Animals; Breast Neoplasms; Cellular Reprogramming; Dendritic Cells; Female; Humans; Lactic Acid; Mic | 2019 |
EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Fluorodeoxyglucose F | 2019 |
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors.
Topics: Aged; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Energy Metabolism; Exercise Test; | 2019 |
Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines.
Topics: Adenosine Triphosphate; Aminopyridines; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell | 2019 |
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment.
Topics: Animals; Antigen-Presenting Cells; Breast Neoplasms; Cell Proliferation; Cyclic AMP; Dendritic Cells | 2020 |
Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO
Topics: Aged; Anaerobic Threshold; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Exercise Tes | 2020 |
Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer.
Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Female; Humans; Lactic Acid; Neoplasms, Hormone-Depende | 2020 |
Why Warburg Works: Lactate Controls Immune Evasion through GPR81.
Topics: Antigen-Presenting Cells; Breast Neoplasms; Humans; Immune Evasion; Lactic Acid; Receptors, G-Protei | 2020 |
Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Female; Glycolysis; Humans; Lactate Dehydrogenase | 2020 |
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
Topics: Actins; Animals; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Epigenomics; Fem | 2020 |
Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy.
Topics: Adenosine A2 Receptor Antagonists; Animals; Breast Neoplasms; Cancer Vaccines; CD8-Positive T-Lympho | 2020 |
Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation.
Topics: Angiogenesis Inhibitors; Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Cell Line | 2020 |
Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chick Embryo; Chitosan; Colonic | 2020 |
Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer.
Topics: Breast Neoplasms; Forkhead Box Protein M1; Humans; Lactic Acid; Phosphatidylinositol 3-Kinases; Prot | 2020 |
Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer.
Topics: Adult; Antibiotics, Antineoplastic; Bicarbonates; Breast Neoplasms; Carbon-13 Magnetic Resonance Spe | 2020 |
Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glucose; Glycoly | 2020 |
Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics.
Topics: Acidosis; Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Isotopes; Lactic Acid; Met | 2020 |
Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity.
Topics: Adipose Tissue; Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Follow-Up Studies; Human | 2020 |
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Dis | 2021 |
Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
Topics: Animals; Breast; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epidermal Growth Factor; Epit | 2021 |
Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line.
Topics: Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Express | 2021 |
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; L-Lactate Deh | 2021 |
Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids.
Topics: Adaptive Immunity; Adenosine; Adoptive Transfer; Breast Neoplasms; Cell Hypoxia; Female; Humans; Hyd | 2021 |
LncRNA SNHG5 promotes the glycolysis and proliferation of breast cancer cell through regulating BACH1 via targeting miR-299.
Topics: Basic-Leucine Zipper Transcription Factors; Breast Neoplasms; Cell Proliferation; Female; G1 Phase; | 2022 |
Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.
Topics: Adenosine Triphosphate; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Female; | 2017 |
Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Mo | 2017 |
A novel long-acting biodegradable depot formulation of anastrozole for breast cancer therapy.
Topics: Absorbable Implants; Anastrozole; Animals; Breast Neoplasms; Drug Implants; Female; Humans; Lactic A | 2017 |
Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer.
Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Proliferation; Curcumin; Cytokines; Delayed | 2018 |
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
Topics: 3' Untranslated Regions; Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement; | 2017 |
[Heregulin-β1-induced Glycolysis Promotes Migration of Breast Cancer Cell Line MCF7].
Topics: Breast Neoplasms; Cell Movement; Glucose; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; L | 2016 |
Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response.
Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Drug | 2017 |
Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Chr | 2017 |
Nanoparticle-based delivery of an anti-proliferative metal chelator to tumor cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chelating Agents; Humans; Iron; Lactic | 2017 |
Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A).
Topics: A549 Cells; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Huma | 2018 |
The in vitro study of Her-2 targeted gold nanoshell liquid fluorocarbon poly lactic-co-glycolic acid ultrasound microcapsule for ultrasound imaging and breast tumor photothermal therapy.
Topics: Breast Neoplasms; Capsules; Cell Line, Tumor; Cell Survival; Contrast Media; Female; Flow Cytometry; | 2018 |
Sustained Release Talazoparib Implants for Localized Treatment of
Topics: Animals; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Female; Lactic Acid; Mice; Microscopy, E | 2017 |
Glycol chitosan assisted in situ reduction of gold on polymeric template for anti-cancer theranostics.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chitosan; Female; Gold; Humans; Hyperthermia, Indu | 2018 |
Vitamin D
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Cholecalciferol; Enzyme | 2018 |
The FAQUIRE Approach: FAst, QUantitative, hIghly Resolved and sEnsitivity Enhanced
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Choline; Female; Humans; Hydrogen; | 2018 |
Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer.
Topics: Animals; Annexin A2; Antibodies, Monoclonal; Breast Neoplasms; Cell Line, Tumor; Curcumin; Female; H | 2016 |
Simultaneous Targeting of Differentiated Breast Cancer Cells and Breast Cancer Stem Cells by Combination of Docetaxel- and Sulforaphane-Loaded Self-Assembled Poly(D, L-lactide-co-glycolide)/Hyaluronic Acid Block Copolymer-Based Nanoparticles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Docetaxel; Drug C | 2016 |
The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer.
Topics: Amine Oxidase (Copper-Containing); Animals; Bacteria; Breast Neoplasms; Claudin-1; Claudins; Female; | 2018 |
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu | 2017 |
Chitosan Stabilized Gold-Folate-Poly(lactide-co-glycolide) Nanoplexes Facilitate Efficient Gene Delivery in Hepatic and Breast Cancer Cells.
Topics: Breast Neoplasms; Chitosan; Female; Folic Acid; Genetic Therapy; Gold; Humans; Lactic Acid; Nanopart | 2018 |
Functionalized Magnetic PLGA Nanospheres for Targeting and Bioimaging of Breast Cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Contrast Media; Humans; Lactic Acid; Magnetic Resonance Imaging; | 2018 |
Preparation of PLGA/Rose Bengal colloidal particles by double emulsion and layer-by-layer for breast cancer treatment.
Topics: Adsorption; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Su | 2018 |
Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal | 2018 |
Investigation of antitumor activities of trastuzumab delivered by PLGA nanoparticles.
Topics: Antineoplastic Agents, Immunological; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Libera | 2018 |
Preparation and Imaging Investigation of Dual-targeted C
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Female; Fluorocarbons; Humans; Lactic A | 2018 |
Muscular endurance and progression rates of early-stage invasive ductal carcinoma: A pilot study.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Case-Control Studies; Disease Progression; | 2018 |
Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent.
Topics: Animals; Antibodies; Breast Neoplasms; Contrast Media; Female; Gold; Humans; Lactic Acid; MCF-7 Cell | 2018 |
Preparation of psoralen polymer-lipid hybrid nanoparticles and their reversal of multidrug resistance in MCF-7/ADR cells.
Topics: Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Chemist | 2018 |
A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells.
Topics: Animals; Biological Transport; Breast Neoplasms; Carbonic Anhydrase II; Female; Humans; Lactic Acid; | 2018 |
The Effects of Thiamine on Breast Cancer Cells.
Topics: Anaerobiosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Culture Media; Dose-Response Rela | 2018 |
Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Collagenases; Drug Carriers; Female; Humans; Hydro | 2018 |
Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid; Down-Regulation; Female; Gene E | 2018 |
Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytotoxicity, Immunolog | 2018 |
Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tum | 2018 |
Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer.
Topics: Animals; Antineoplastic Agents, Immunological; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor | 2019 |
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Hypoxia-Indu | 2018 |
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Gefitinib; Humans; L | 2018 |
Lactic Acid Accumulation in the Tumor Microenvironment Suppresses
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Fluorodeoxygl | 2019 |
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Femal | 2019 |
Topics: A549 Cells; Aged; Apoptosis; Brain; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Non-Smal | 2018 |
Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cancer-Associated Fibroblasts; Ca | 2019 |
Multiplexed Single-Cell Measurements of FDG Uptake and Lactate Release Using Droplet Microfluidics.
Topics: Biological Transport; Breast Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Lactic Acid; Microfl | 2019 |
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells.
Topics: Aerobiosis; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Extracellular Vesicles; | 2019 |
High Glucose-reduced Apoptosis in Human Breast Cancer Cells Is Mediated by Activation of NF-κB.
Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Glucose; Humans; Lactic Acid; MCF-7 Cells; | 2019 |
Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast; Breast Neoplasms; Carcinoma; Cell Line, T | 2019 |
High extracellular lactate causes reductive carboxylation in breast tissue cell lines grown under normoxic conditions.
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Culture Techniques; Cell Line, Tumor; Citric Ac | 2019 |
[Possibilities of cytological diagnostics of lactated breast adenoma. Clinical report.]
Topics: Adenoma; Breast Neoplasms; Cytodiagnosis; Female; Humans; Lactic Acid; Pregnancy | 2019 |
Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Breast Neoplasms; Catechin; Cell Line, Tumor | 2019 |
Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxo | 2013 |
Poly(D, L-lactide-co-glycolide)/montmorillonite nanoparticles for improved oral delivery of exemestane.
Topics: Androstadienes; Antineoplastic Agents; Bentonite; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; | 2013 |
Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer.
Topics: Acetylglucosamine; Biomarkers, Tumor; Breast Neoplasms; Electrophoresis, Gel, Two-Dimensional; Femal | 2013 |
Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior.
Topics: Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Movement; Cell | 2013 |
Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Catechin; Cell Death; Cell Proliferation; Female | 2013 |
Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells.
Topics: Alginates; Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Pro | 2013 |
Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Cell Survival; Chromato | 2013 |
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; | 2013 |
Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Caco-2 Cells; Fema | 2013 |
N-lauroyl chitosan surface-modified PLGA nanoparticles as carrier for adriamycin to overcome cancer drug resistance.
Topics: Breast Neoplasms; Cell Line, Tumor; Chitosan; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm; | 2014 |
Altered glucose metabolism in Harvey-ras transformed MCF10A cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Transformation, Neoplastic; Citric Acid Cycl | 2015 |
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
Topics: Adult; Aged; Alanine; Animals; Breast Neoplasms; Cell Death; Cell Hypoxia; Cell Line, Tumor; Coumari | 2013 |
Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures.
Topics: Breast Neoplasms; Carbon Isotopes; Cell Survival; Female; Glucose; Glycolysis; Humans; Lactic Acid; | 2013 |
Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Breast Neoplasms; Carbohydrate Sequence; Ce | 2014 |
Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells.
Topics: Antineoplastic Agents; Aptamers, Nucleotide; Breast Neoplasms; Cell Line; Cell Line, Tumor; Drug Del | 2014 |
A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing.
Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Carriers; Female; Humans; | 2014 |
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glucose; Glycolysis; Humans; Lactic Acid; Male; NAD; Pro | 2014 |
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
Topics: Active Transport, Cell Nucleus; Allosteric Site; Breast Neoplasms; Carrier Proteins; Cell Line, Tumo | 2014 |
Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Humans; Lactic | 2014 |
GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.
Topics: 3T3 Cells; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms; Carcinoma, | 2014 |
Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Respiration; Down-Regulation; Epithelial Cells; Female; Gen | 2014 |
Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Carriers; Drug Resistance, Neoplas | 2014 |
Development of intrinsically photoluminescent and photostable polylactones.
Topics: Animals; Biocompatible Materials; Breast Neoplasms; Diagnostic Imaging; Drug Delivery Systems; Femal | 2014 |
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Aci | 2014 |
Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.
Topics: Amino Acid Motifs; Animals; Biological Transport; Breast Neoplasms; Down-Regulation; Female; Glucose | 2014 |
Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Female | 2016 |
Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.
Topics: Apoptosis; Biological Transport; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferatio | 2015 |
Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, | 2016 |
Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells.
Topics: 3T3-L1 Cells; Animals; Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Line, Tumor; Cell | 2014 |
Poly(2-ethyl-2-oxazoline)-PLA-g-PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics.
Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; DNA, Circular; Doxorubicin | 2014 |
Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Carrie | 2014 |
Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Emulsions; Female; Humans; | 2014 |
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology; Gene S | 2014 |
Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer.
Topics: Animals; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Lactic Acid; Nanoparticles; Rats; | 2015 |
Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy.
Topics: Antigens, Neoplasm; Apoptosis; Breast Neoplasms; Cell Adhesion Molecules; Drug Delivery Systems; Epi | 2015 |
Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspa | 2014 |
A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Combin | 2015 |
A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Gene Expression Regulation | 2016 |
Co-delivery of docetaxel and Poloxamer 235 by PLGA-TPGS nanoparticles for breast cancer treatment.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Docetaxel; Drug Carriers; Drug Resistance | 2015 |
High tolerated paclitaxel nano-formulation delivered by poly (lactic-co-glycolic acid)-g-dextran micelles to efficient cancer therapy.
Topics: Animals; Breast Neoplasms; Dextrans; Drug Resistance, Neoplasm; Female; Lactic Acid; MCF-7 Cells; Mi | 2015 |
Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Compounding; Drug Del | 2015 |
Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.
Topics: Brain Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cell Hypoxia; Choline; Female; Humans; Lactic | 2015 |
Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.
Topics: Animals; Antigen Presentation; Breast Neoplasms; Cancer Vaccines; Cell Transformation, Neoplastic; D | 2015 |
Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Caseins; Catechin; Cell Line, Tumor; Drug Resis | 2015 |
Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ce | 2015 |
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice.
Topics: Animals; Basigin; Breast Neoplasms; Cell Line, Tumor; ERRalpha Estrogen-Related Receptor; Female; Hu | 2015 |
Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cell Survival; Coculture Technique | 2015 |
Preparation and Evaluation of Chrysin Encapsulated in PLGA- PEG Nanoparticles in the T47-D Breast Cancer Cell Line.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclin D1; Drug Carr | 2015 |
Nutrient depletion and metabolic profiles in breast carcinoma cell lines measured with a label-free platform.
Topics: Actins; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Survival; Cytocha | 2015 |
Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiox | 2016 |
Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line, | 2015 |
Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line.
Topics: Breast Neoplasms; Cytotoxins; Drug Carriers; Female; Flavonoids; Humans; Lactic Acid; MCF-7 Cells; N | 2016 |
A study of the relationship of metabolic MR parameters to estrogen dependence in breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Humans; Lactic Acid; Magn | 2015 |
Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Female | 2015 |
A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Hypoxia; Cell Proliferation; Dose-Response | 2015 |
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Ag | 2015 |
Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Sur | 2015 |
PLGA nanoparticle formulation of RK-33: an RNA helicase inhibitor against DDX3.
Topics: Animals; Antineoplastic Agents; Azepines; Breast Neoplasms; Carcinoma; Cell Survival; Delayed-Action | 2015 |
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
Topics: Antigens, Neoplasm; Breast Neoplasms; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalysis; Cell Hy | 2015 |
Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Energy Metabolism; Epithel | 2015 |
Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid).
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Chitosan; Female; Humans; Lactic Acid; Mice; Mice, Inbr | 2016 |
Multifunctional PLGA Nanobubbles as Theranostic Agents: Combining Doxorubicin and P-gp siRNA Co-Delivery Into Human Breast Cancer Cells and Ultrasound Cellular Imaging.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Co | 2015 |
Preparation of Engineered Salmonella Typhimurium-Driven Hyaluronic-Acid-Based Microbeads with Both Chemotactic and Biological Targeting Towards Breast Cancer Cells for Enhanced Anticancer Therapy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chemotaxis; Docetaxe | 2016 |
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.
Topics: Antineoplastic Agents; Biomechanical Phenomena; Breast Neoplasms; Cell Line, Tumor; Cell Proliferati | 2016 |
Enhanced delivery of Paclitaxel using electrostatically-conjugated Herceptin-bearing PEI/PLGA nanoparticles against HER-positive breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Drug Screening As | 2016 |
Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin.
Topics: Animals; Antibiotics, Antineoplastic; Biotinylation; Breast Neoplasms; Carbocyanines; Cell Survival; | 2016 |
Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles.
Topics: 5'-Nucleotidase; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chitosan; Down-Regulati | 2016 |
Modulation of the uptake of critical nutrients by breast cancer cells by lactate: Impact on cell survival, proliferation and migration.
Topics: Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Su | 2016 |
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth.
Topics: Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Drug Carriers; Humans; Lactic Ac | 2016 |
Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery.
Topics: Animals; Breast; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Delayed-Action Preparation | 2016 |
Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Drug Carriers; Female; Gonadot | 2016 |
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors.
Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Coculture Techniques; Epithelial Cells; G | 2017 |
Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Disulfiram; Drug Carriers; Female; Folate Recepto | 2016 |
Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Line, Tu | 2016 |
PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Silencing | 2016 |
Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tum | 2016 |
Voxel-by-voxel correlations of perfusion, substrate, and metabolite signals in dynamic hyperpolarized (13) C imaging.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, | 2016 |
Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Breast Neoplasms; Cell Survival | 2016 |
Molecular mechanism of (18)F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism.
Topics: Biological Transport; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relations | 2016 |
Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue.
Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor | 2016 |
3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells.
Topics: Adenosine Triphosphate; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Feedback, Physiological; | 2016 |
Transformation by different oncogenes relies on specific metabolic adaptations.
Topics: Adaptation, Physiological; Animals; Breast Neoplasms; Cell Respiration; Cell Transformation, Neoplas | 2016 |
Adrenal Hormone and Metabolic Biomarker Responses to 30 min of Intermittent Cycling Exercise in Breast Cancer Survivors.
Topics: Adult; Aged; Bicycling; Biomarkers; Blood Glucose; Breast Neoplasms; Case-Control Studies; Epinephri | 2016 |
A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors.
Topics: Animals; Antibodies, Antinuclear; Antibodies, Catalytic; Breast Neoplasms; Cell Line, Tumor; DNA; Do | 2016 |
Measuring relative utilization of aerobic glycolysis in breast cancer cells by positional isotopic discrimination.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Lactic Acid; Mice; Mice, In | 2016 |
Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen.
Topics: Administration, Topical; Animals; Breast Neoplasms; Chitosan; Drug Carriers; Female; Humans; Lactic | 2016 |
Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses.
Topics: Adult; Breast Neoplasms; Cancer Survivors; Cell Line, Tumor; Cholesterol; Cytokines; Epinephrine; Ex | 2016 |
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
Topics: Adenosine Triphosphate; Algorithms; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferatio | 2016 |
Tumor stroma-containing 3D spheroid arrays: A tool to study nanoparticle penetration.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Female; Humans; Lactic Acid; Mice | 2016 |
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.
Topics: Amphiregulin; Animals; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ce | 2016 |
Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens.
Topics: Antigens, Neoplasm; Breast Neoplasms; Cancer Vaccines; Cells, Cultured; Dendritic Cells; Female; Hum | 2016 |
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Coculture Techniques; Female; Fibroblast | 2016 |
Formulation and evaluation of targeted nanoparticles for breast cancer theranostic system.
Topics: Breast Neoplasms; Cell Survival; Drug Compounding; Drug Delivery Systems; Drug Evaluation, Preclinic | 2017 |
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
Topics: Acetyl Coenzyme A; Aspartic Acid; Biosynthetic Pathways; Breast Neoplasms; Cell Line, Tumor; Cell Pr | 2017 |
Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Drug Carriers; Drug Delivery Systems; Fema | 2017 |
Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells.
Topics: Breast Neoplasms; Drug Delivery Systems; Humans; Indocyanine Green; Lactic Acid; MCF-7 Cells; Nanopa | 2016 |
CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice.
Topics: 5'-Nucleotidase; Animals; Breast; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Chitosan; Den | 2017 |
Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetyl Coenzyme A; Aldehyde Dehydrogenase 1 Family; Animals; Apoptosis; | 2017 |
Synthesis, characterization, and in vitro evaluation of targeted gold nanoshelled poly(d,l-lactide-co-glycolide) nanoparticles carrying anti p53 antibody as a theranostic agent for ultrasound contrast imaging and photothermal therapy.
Topics: Breast Neoplasms; Chemistry Techniques, Synthetic; Contrast Media; Gold; Humans; Immunoconjugates; L | 2017 |
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema | 2017 |
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam | 2016 |
l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis.
Topics: Apoptosis; Arginine; Breast Neoplasms; Cell Movement; Cell Survival; Chemokine CXCL12; Female; Fluor | 2017 |
Tumor stroma interaction is mediated by monocarboxylate metabolism.
Topics: Autocrine Communication; Breast Neoplasms; Carbon Radioisotopes; Cell Communication; Cells, Cultured | 2017 |
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; | 2017 |
The Effect of Chrysin Loaded PLGA-PEG on Metalloproteinase Gene Expression in Mouse 4T1 Tumor Model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carrier | 2017 |
CXCR4-targeted Nanoparticles Reduce Cell Viability, Induce Apoptosis and Inhibit SDF-1α Induced BT-549-Luc Cell Migration In Vitro.
Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Cell Su | 2017 |
Co-delivery of Doxorubicin Encapsulated PLGA Nanoparticles and Bcl-xL shRNA Using Alkyl-Modified PEI into Breast Cancer Cells.
Topics: bcl-X Protein; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Imines; Lactic Acid; MCF-7 C | 2017 |
Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug | 2017 |
Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models.
Topics: Acoustics; Breast Neoplasms; Carbocyanines; Contrast Media; Female; Fluorescent Dyes; Fluorocarbons; | 2017 |
Regulation of the Warburg effect in early-passage breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Glucose; Glucose Transp | 2008 |
Rhodamine-loaded poly(lactic-co-glycolic acid) nanoparticles for investigation of in vitro interactions with breast cancer cells.
Topics: Biocompatible Materials; Biological Transport, Active; Breast Neoplasms; Cell Line, Tumor; Drug Deli | 2009 |
The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Cycloo | 2008 |
The genomic analysis of lactic acidosis and acidosis response in human cancers.
Topics: Acidosis; Breast Neoplasms; Cells, Cultured; Energy Metabolism; Female; Gene Expression Profiling; G | 2008 |
Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique.
Topics: Breast Neoplasms; Calorimetry, Differential Scanning; Cell Line, Tumor; Chemistry, Pharmaceutical; D | 2009 |
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
Topics: Antigens, Neoplasm; Breast Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic | 2009 |
Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma; Cell Hypoxia; Cell Survival | 2009 |
Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents.
Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Delayed- | 2009 |
Inactivation of harmful tumour-associated proteolysis by nanoparticulate system.
Topics: Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Caco-2 Cells; Cathepsin B; Cell Adhe | 2009 |
Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cells.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents, | 2009 |
Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; ErbB | 2009 |
A dual-emissive-materials design concept enables tumour hypoxia imaging.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neopla | 2009 |
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; | 2009 |
Sustained delivery and efficacy of polymeric nanoparticles containing osteopontin and bone sialoprotein antisenses in rats with breast cancer bone metastasis.
Topics: Animals; Bone Neoplasms; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Integrin-Binding S | 2010 |
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7.
Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brea | 2010 |
Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Carbon Isotopes; Cell Hypoxia; Cell Survival; Humans; Kineti | 2009 |
Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells.
Topics: Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, | 2010 |
Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Membrane Permeability; Cell | 2010 |
Hypoxia induces differential translation of enolase/MBP-1.
Topics: Breast Neoplasms; Cell Cycle; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; DNA-Binding Pro | 2010 |
Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor | 2010 |
Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: effects of surfactants on particles size, characteristics and in vitro performance.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Pha | 2010 |
Preparation and in-vitro/in-vivo evaluation of surface-modified poly (lactide-co-glycolide) fluorescent nanoparticles.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Chitosan; Coumarins; Drug Carrier | 2010 |
Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, | 2010 |
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Topics: Autophagy; Biological Evolution; Breast Neoplasms; Caveolin 1; Cell Line; Coculture Techniques; DNA | 2010 |
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female | 2010 |
Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation.
Topics: Breast Neoplasms; Chemical Phenomena; Drug Carriers; Drug Delivery Systems; Drug Stability; Estrogen | 2010 |
The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Lactic Aci | 2011 |
Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation.
Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line; Cell Line, Tumor; Gene Knock-In Techniq | 2010 |
Exercise in patients with breast cancer and healthy controls: energy substrate oxidation and blood lactate responses.
Topics: Blood Glucose; Breast Neoplasms; Carbohydrate Metabolism; Case-Control Studies; Energy Metabolism; E | 2011 |
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hypoxia-Ind | 2011 |
Chondroitin sulphate decorated nanoparticulate carriers of 5-fluorouracil: development and in vitro characterization.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Chondroitin Sulfates; Drug Carr | 2010 |
Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Line, Tumor; DNA; Female; Gene Transfer Techniques; Genetic T | 2011 |
Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Nu | 2011 |
13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns.
Topics: Alanine; Animals; Breast Neoplasms; Carbon Isotopes; Female; Gene Expression Regulation, Neoplastic; | 2011 |
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Transport; Breast Neoplasms; C | 2011 |
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
Topics: Acetyl Coenzyme A; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Citric Acid Cycle; Female; | 2011 |
Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues.
Topics: Actins; Anticarcinogenic Agents; Breast Neoplasms; Clotrimazole; Female; Glucose; Glycolysis; Humans | 2011 |
Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Creatine Kinase; D | 2011 |
Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Enzymologic; Gene Expression | 2011 |
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Line, | 2011 |
Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Topics: Animals; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cellular Senescence; Coculture Techniques; | 2011 |
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment.
Topics: Breast Neoplasms; Carcinoma; Cell Communication; Cell Line, Tumor; Female; Fibroblasts; Glycolysis; | 2012 |
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Topics: Animals; Autophagy; Breast Neoplasms; Caveolin 1; Cell Communication; Cell Growth Processes; Cell Li | 2011 |
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyl | 2012 |
Bypassing multidrug resistance in human breast cancer cells with lipid/polymer particle assemblies.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfami | 2012 |
Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.
Topics: Adult; Aged; Biomarkers; Breast Neoplasms; Caveolin 1; Cohort Studies; Epithelium; Female; Fibroblas | 2012 |
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Butyrates; Cell Line, Tumor; Cell Su | 2012 |
Folate receptor targeted 17-allylamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric nanoparticles for breast cancer.
Topics: Antineoplastic Agents; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carrie | 2012 |
Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cohort Studies; Discriminant An | 2012 |
RGD-conjugated PLA-PLL nanoparticles targeting to Bacp-37 breast cancer xenografts in vivo.
Topics: Biocompatible Materials; Breast Neoplasms; Female; Flow Cytometry; Humans; Lactic Acid; Lysine; Micr | 2011 |
Poly-lactic-glycolic-acid surface nanotopographies selectively decrease breast adenocarcinoma cell functions.
Topics: Adenocarcinoma; Apoptosis; Breast; Breast Neoplasms; Cell Adhesion; Cell Count; Cell Line, Tumor; Ce | 2012 |
Lactate-induced IL-8 pathway in endothelial cells--letter.
Topics: Breast Neoplasms; Colorectal Neoplasms; Humans; Interleukin-8; Lactic Acid; Monocarboxylic Acid Tran | 2012 |
Superparamagnetic PLGA-iron oxide microcapsules for dual-modality US/MR imaging and high intensity focused US breast cancer ablation.
Topics: Animals; Breast; Breast Neoplasms; Capsules; Contrast Media; Female; Ferric Compounds; High-Intensit | 2012 |
Regulation of glycolysis and the Warburg effect by estrogen-related receptors.
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tum | 2013 |
Alendronate coated poly-lactic-co-glycolic acid (PLGA) nanoparticles for active targeting of metastatic breast cancer.
Topics: Alendronate; Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Boronic Acids; Bortezom | 2012 |
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
Topics: Animals; Autocrine Communication; Autophagy; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Tr | 2012 |
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Electron Transport | 2012 |
CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cellular Senescence; Cyclin-De | 2012 |
Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Female; Humans; Lactic Acid; Male; MCF-7 Cells; Mito | 2013 |
Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors.
Topics: Adult; Aged; Anaerobic Threshold; Breast Neoplasms; Cardiovascular Deconditioning; Exercise Test; Fa | 2013 |
Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Gene Expression Regulation, Neopla | 2012 |
Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
Topics: Acetyl-CoA C-Acetyltransferase; Breast Neoplasms; Caveolin 1; Cell Line; Chaperonin 60; Coculture Te | 2012 |
Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Delaye | 2013 |
Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts.
Topics: Animals; Breast Neoplasms; Female; Fibroblasts; Humans; Lactic Acid; Paracrine Communication; Transf | 2012 |
Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells.
Topics: Apoptosis; Biocompatible Materials; Biological Availability; Breast Neoplasms; Cell Cycle Checkpoint | 2013 |
Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS.
Topics: Animals; Biomarkers; Breast Neoplasms; Carbon Isotopes; Disease Models, Animal; Female; Glucose; Gly | 2002 |
Polymeric contrast agent with targeting potential.
Topics: Analysis of Variance; Breast Neoplasms; Contrast Media; Diagnosis, Differential; Humans; Lactic Acid | 2004 |
Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres.
Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Chemistry, Pharmaceutic | 2004 |
Metabolism of the microregions of human breast cancer.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fructose-Bisphosphate | 2004 |
Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions.
Topics: Acrylamides; Acrylic Resins; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Coa | 2005 |
Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes.
Topics: Actins; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Cell Survival; Clotrimazole; | 2005 |
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme I | 2006 |
Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens.
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bioreactors; Breast Neoplasms; Cell Line, Tumor; | 2006 |
Proliferation, viability, and metabolism of human tumor and normal cells cultured in microcapsule.
Topics: Alginates; Biocompatible Materials; Biotechnology; Breast Neoplasms; Cell Culture Techniques; Cell L | 2006 |
Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis.
Topics: Algorithms; Amino Acids; Biosynthetic Pathways; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; | 2006 |
Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery.
Topics: Animals; Breast Neoplasms; Capsules; Cell Line, Tumor; Cell Survival; Coated Materials, Biocompatibl | 2007 |
TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Nucl | 2007 |
The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Combined Modality Therapy; De | 2007 |
Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody.
Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Breast Neoplasms; Caco-2 Cells; Ce | 2007 |
Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bentonite; Breast Neoplasms; Cell Line, T | 2008 |
Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy.
Topics: ADP Ribose Transferases; Animals; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Agent | 2008 |
The effect of ifosfamide on tumor oxygenation at different temperatures.
Topics: Animals; Breast Neoplasms; Female; Humans; Hydrogen-Ion Concentration; Ifosfamide; Lactates; Lactic | 1994 |
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
Topics: Base Sequence; Breast Neoplasms; Cathepsin D; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-4 | 1993 |
Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism.
Topics: Acids; Amiloride; Anti-Bacterial Agents; Breast; Breast Neoplasms; Cells, Cultured; Extracellular Sp | 1997 |
Metabolism in myocutaneous flaps studied by in situ microdialysis.
Topics: Adult; Aged; Blood Glucose; Breast Neoplasms; Combined Modality Therapy; Energy Metabolism; Female; | 1998 |
Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Diag | 1998 |
Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation.
Topics: Adenosine Triphosphate; Amiloride; Ammonium Chloride; Androstadienes; Blood; Blotting, Western; Brea | 2000 |
Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy.
Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Energy | 2001 |
Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specific | 2001 |
Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line; Culture Media; Dose-Response Relationship, D | 2002 |
Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells.
Topics: Adenosine Triphosphate; Air; Breast Neoplasms; Cell Division; Cells, Cultured; Fatty Acids; Glucose; | 2002 |
Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres.
Topics: Aged; Breast Neoplasms; Chest Tubes; Delayed-Action Preparations; Doxorubicin; Drainage; Drug Carrie | 1991 |
Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy.
Topics: Breast Neoplasms; Cell Line; Estradiol; Glucose; Glutamates; Glutamic Acid; Humans; Lactates; Lactic | 1989 |
Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats.
Topics: Animals; Breast Neoplasms; Glucose; Humans; Hydrogen-Ion Concentration; Ketone Bodies; Lactates; Lac | 1988 |
A versatile multinuclear probe designed for in vivo NMR spectroscopy: applications to subcutaneous human tumors in mice.
Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Glucose; Humans; In Vitro Techniques; Infant, Newborn; | 1988 |
Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Breast Neoplasms; Carcinoma; Female; Glucose; Humans; | 1985 |