Page last updated: 2024-10-17

lactic acid and Breast Neoplasms

lactic acid has been researched along with Breast Neoplasms in 308 studies

Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.

Breast Neoplasms: Tumors or cancer of the human BREAST.

Research Excerpts

ExcerptRelevanceReference
"In the present study, we synthesized a novel nanostructure for the co-delivery of curcumin and siRNA to breast cancer cells."8.12Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles. ( Azedi, F; Bayandori, M; Hamblin, MR; Hasanzadeh, A; Heidari, E; Karimi, M; Mohammad Gholinia Sarpoli, L; Zare-Karizi, S, 2022)
" In the present study, we evaluated the efficacy of CD73-specific siRNA-loaded chitosan-lactate nanoparticles (ChLa NPs) in combination with tumor lysate pulsed dendritic cells (DCs) vaccine in treatment of 4T1 (murine derived) breast cancer bearing mice."7.85CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. ( Ajami, M; Arab, S; Atyabi, F; Habibi, S; Hadjati, J; Hassannia, H; Jadidi-Niaragh, F; Kheshtchin, N; Masoumi, F; Mirsanei, Z; Noorbakhsh, F; Rastegari, A; Shokri, F, 2017)
" The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer."7.83Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer. ( Mukerjee, A; Ranjan, AP; Vishwanatha, JK, 2016)
"In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells."7.83A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR. ( Akbarzadeh, A; Barkhordari, A; Ghasemali, S; Kordi, S; Rahmati, YM; Tozihi, M; Zarghami, N, 2016)
"A folate-receptor-targeted poly (lactide-co-Glycolide) (PLGA)-Polyethylene glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into breast cancer cells."7.83Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations. ( Dinarvand, R; Esfandyari-Manesh, M; Faghihi, S; Fasehee, H; Ghaffari, SH; Ghavamzadeh, A; Moradian, H, 2016)
"Paclitaxel is a commonly used agent for breast cancer therapy, which comes across the obstacle "drug resistance", resulting in shortened overall survival of patients."7.83PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production. ( Cao, Z; Ge, X; Gu, Y; Han, M; Li, J; Lyu, P; Wang, F; Xia, W; Yu, Z, 2016)
"This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer."7.81Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. ( Ghosh, S; Haldar, C; Maiti, P; Pandey, SK, 2015)
" With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release."7.81Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells. ( Chen, C; Hu, K; Li, J; Liu, J; Liu, Y; Liu, Z; Sheng, W; Tang, J; Wu, Y; Zhang, J; Zhao, Y; Zhou, H, 2015)
"The present study was performed to investigate the therapeutic performance of polymer-lipid hybrid nanoparticles towards the delivery of lapatinib (LPT) in breast cancers."7.81Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation. ( Huo, ZJ; Liu, K; Liu, P; Pang, B; Wang, SJ; Wang, ZQ; Zuo, WS, 2015)
"Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients."7.81Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. ( Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH, 2015)
"The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer."7.79Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013)
"In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation."7.79Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. ( Araújo, I; Correia-Branco, A; Costa, T; Faria, A; Keating, E; Martel, F; Moreira, L, 2013)
"A star-shaped biodegradable polymer, mannitol-core poly(d,l-lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (M-PLGA-TPGS), was synthesized in order to provide a novel nanoformulation for breast cancer chemotherapy."7.79Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy. ( Huang, L; Liu, T; Mei, L; Ouyang, C; Tao, W; Wang, Z; Xiong, Q; Zeng, X, 2013)
"Human breast cancer tissues, as well as normal tissues from the same patients, were treated with clotrimazole (CTZ) and have their capacities for glucose consumption and lactate production evaluated."7.77Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues. ( Calaça, Ide C; Celestrini, Dde M; Coelho, RG; Correia, AH; Costa, MA; Sola-Penna, M, 2011)
" Two important determinants in this environment are hypoxia and lactic acidosis."7.74The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
"The effects of 17 beta-estradiol treatment versus tamoxifen on the metabolism of human breast cancer T47D-clone 11 cells were studied by noninvasive 31P and 13C nuclear magnetic resonance techniques."7.67Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy. ( Degani, H; Neeman, M, 1989)
" The current research attempted to develop poly (lactic-co-glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design."5.91Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application. ( Gandhi, S; Kavisri, M; Maddiboyina, B; Moovendhan, M; Nakkala, RK; Roy, H, 2023)
"Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis."5.56Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020)
"Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation."5.48Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018)
"The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)."5.46Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017)
"Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types."5.46l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017)
"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut."5.43Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. ( Domb, AJ; Katiyar, SS; Khan, W; Muntimadugu, E; Rafeeqi, TA, 2016)
"Chrysin is a natural flavonoid which has been reported to have some significant biological effects on the processes of chemical defense, nitrogen fixation, inflammation, and oxidation."5.43Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. ( Akbarzadeh, A; Anari, E; Zarghami, N, 2016)
"In our current studies, using breast cancer cell lines, we determined the protective role of OA in high salt-mediated osmotic stress-induced cancer growth."5.43Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. ( Amara, S; Tiriveedhi, V; Zheng, M, 2016)
"Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity."5.43Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer. ( Dai, Z; Du, Y; Jing, L; Li, X; Li, Y; Liang, X; Tian, J; Zhang, Q, 2016)
"Breast cancer is the most common cancer in women worldwide."5.42Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. ( Koyakutty, M; Menon, D; Mony, U; Narayanan, S; Paul-Prasanth, B; Vijaykumar, DK, 2015)
" PLGA nanoparticles proved to be completely safe, suggesting a potential utilization of this nanocomplex to improve the intrinsically poor bioavailability of curcumin for the treatment of severe malignant breast cancer."5.39Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. ( Bonetti, P; Colombo, M; Pandolfi, L; Prosperi, D; Verderio, P, 2013)
"Perifosine is an anticancer alkylphospholipid used in clinical trials."5.38Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012)
"Our results showed that the three breast cancer cell lines used presented different sensitivities to 3-BP: ZR-75-1 ER (+)>MCF-7 ER (+)>SK-BR-3 ER (-)."5.38Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. ( Azevedo-Silva, J; Baltazar, F; Casal, M; Ko, YH; Moreira, R; Pacheco, A; Pedersen, PL; Pedro, M; Pinheiro, C; Preto, A; Queirós, O, 2012)
"Biopsies from breast cancer patients (n=98) were excised during surgery and analyzed by high-resolution magic angle spinning MRS."5.38Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers. ( Bathen, TF; Buydens, LM; Fjøsne, HE; Giskeødegård, GF; Gribbestad, IS; Lundgren, S; Postma, G; Sitter, B, 2012)
"Clotrimazole is an anti-fungal azole derivative recently recognized as a calmodulin antagonist with promising anti-cancer effect."5.33Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. ( Da Poian, AT; de Freitas, MS; Holandino, C; Marinho-Carvalho, MM; Meira, DD; Sola-Penna, M; Teixeira, CA; Veiga, VF, 2005)
"In the present study, we synthesized a novel nanostructure for the co-delivery of curcumin and siRNA to breast cancer cells."4.12Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles. ( Azedi, F; Bayandori, M; Hamblin, MR; Hasanzadeh, A; Heidari, E; Karimi, M; Mohammad Gholinia Sarpoli, L; Zare-Karizi, S, 2022)
"In this study, we generated and characterized hyaluronate-PEG-Chitosan-Lactate (H-PCL) nanoparticles (NPs) to simultaneously deliver IL6-specific siRNA and BV6 to 4T1 (breast cancer) and CT26 (colon cancer) cells, and investigate the anti-tumor properties of this combination therapy both in vitro and in vivo."3.96Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression. ( Ahmadi, A; Boroumand-Noughabi, S; Hassannia, H; Heydari, M; Hojjat-Farsangi, M; Izadi, S; Jadidi-Niaragh, F; Karoon Kiani, F; Keramati, MR; Masjedi, A; Mohammadi, H; Sadat Eshaghi, F; Salimifard, S; Shahdadnejad, K, 2020)
" Subsequently, we examined the effects of CYC1 on proliferation, glycolysis and chemosensitivity to paclitaxel, which is one of the most common chemotherapeutic agents in breast cancer, in ER-positive breast carcinoma cells (MCF7 and T47D)."3.91Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma. ( Hara, M; Ishida, T; Miki, Y; Sasano, H; Sato, A; Suzuki, T; Takagi, K; Yoshimura, A, 2019)
" Cotreatment with GPR119 agonist (MBX-2982 or GSK1292263) significantly potentiated gefitinib-induced cell growth inhibition in gefitinib-insensitive MCF-7 and MDA-MB-231 breast cancer cells."3.88GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy. ( An, YJ; Choi, SY; Im, JH; Jeong, BH; Kang, KW; Kim, SY; Kim, YG; Lee, JS; Park, S, 2018)
" In the present study, we evaluated the efficacy of CD73-specific siRNA-loaded chitosan-lactate nanoparticles (ChLa NPs) in combination with tumor lysate pulsed dendritic cells (DCs) vaccine in treatment of 4T1 (murine derived) breast cancer bearing mice."3.85CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice. ( Ajami, M; Arab, S; Atyabi, F; Habibi, S; Hadjati, J; Hassannia, H; Jadidi-Niaragh, F; Kheshtchin, N; Masoumi, F; Mirsanei, Z; Noorbakhsh, F; Rastegari, A; Shokri, F, 2017)
" The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer."3.83Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer. ( Mukerjee, A; Ranjan, AP; Vishwanatha, JK, 2016)
"In this study, we demonstrated that the NC-helenalin complex is more effective than free helenalin in inhibiting the growth of breast cancer cells."3.83A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR. ( Akbarzadeh, A; Barkhordari, A; Ghasemali, S; Kordi, S; Rahmati, YM; Tozihi, M; Zarghami, N, 2016)
"A folate-receptor-targeted poly (lactide-co-Glycolide) (PLGA)-Polyethylene glycol (PEG) nanoparticle is developed for encapsulation and delivery of disulfiram into breast cancer cells."3.83Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations. ( Dinarvand, R; Esfandyari-Manesh, M; Faghihi, S; Fasehee, H; Ghaffari, SH; Ghavamzadeh, A; Moradian, H, 2016)
"Paclitaxel is a commonly used agent for breast cancer therapy, which comes across the obstacle "drug resistance", resulting in shortened overall survival of patients."3.83PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production. ( Cao, Z; Ge, X; Gu, Y; Han, M; Li, J; Lyu, P; Wang, F; Xia, W; Yu, Z, 2016)
"Breast cancer is believed as the second most common cause of cancer-related deaths in women for which tamoxifen is frequently prescribed."3.83Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen. ( Chitkara, D; Kumar, P; Kumar, R; Raza, K; Singh, B; Thakur, CK; Thotakura, N, 2016)
"This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer."3.81Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer. ( Ghosh, S; Haldar, C; Maiti, P; Pandey, SK, 2015)
"Lapatinib (LPT) could sensitize human epidermal growth factor receptor-2 (HER-2) positive breast cancer to paclitaxel (PTX) and induce synergetic action with PTX in preclinical test and phase II/III trial."3.81A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro. ( Cao, S; Jiang, X; Wang, F; Wang, Y; Wei, Y; Xiong, Y; Xu, S; Zhang, Q; Zhang, S; Zou, A, 2015)
" With a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (DOX) and cyclopamine (CYC, a primary inhibitor of the hedgehog signaling pathway of CSCs) to both a CD44-overexpressing breast CSC subpopulation and bulk breast cancer cells and allow an on-demand release."3.81Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells. ( Chen, C; Hu, K; Li, J; Liu, J; Liu, Y; Liu, Z; Sheng, W; Tang, J; Wu, Y; Zhang, J; Zhao, Y; Zhou, H, 2015)
"The present study was performed to investigate the therapeutic performance of polymer-lipid hybrid nanoparticles towards the delivery of lapatinib (LPT) in breast cancers."3.81Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation. ( Huo, ZJ; Liu, K; Liu, P; Pang, B; Wang, SJ; Wang, ZQ; Zuo, WS, 2015)
"Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients."3.81Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells. ( Chung, FF; Hii, LW; Ho, GF; Leong, CO; Malik, RA; Ng, CH; See, MH; Soo, JS; Taib, NA; Tan, BS; Tan, SH; Teh, YC; Teo, SH; Yip, CH, 2015)
"The aim was to evaluate tetraiodothyroacetic acid (tetrac), a thyroid hormone analog of L-thyroxin, conjugated to poly(lactic-co-glycolic acid) nanoparticles (T-PLGA-NPs) both in vitro and in vivo for the treatment of drug-resistant breast cancer."3.79Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer. ( Bharali, DJ; Davis, PJ; Mousa, SA; Yalcin, M, 2013)
"In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism and cell viability and proliferation."3.79Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism. ( Araújo, I; Correia-Branco, A; Costa, T; Faria, A; Keating, E; Martel, F; Moreira, L, 2013)
"A star-shaped biodegradable polymer, mannitol-core poly(d,l-lactide-co-glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (M-PLGA-TPGS), was synthesized in order to provide a novel nanoformulation for breast cancer chemotherapy."3.79Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy. ( Huang, L; Liu, T; Mei, L; Ouyang, C; Tao, W; Wang, Z; Xiong, Q; Zeng, X, 2013)
"Human breast cancer tissues, as well as normal tissues from the same patients, were treated with clotrimazole (CTZ) and have their capacities for glucose consumption and lactate production evaluated."3.77Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues. ( Calaça, Ide C; Celestrini, Dde M; Coelho, RG; Correia, AH; Costa, MA; Sola-Penna, M, 2011)
" In this study, we evaluated the effects of RGD-conjugated poly (lactic acid-co-lysine)-(Arginine-Glycine-Aspartic) nanoparticles (PLA-PLL-RGD NPs) on targeted delivery to Bacp-37 breast cancer bearing mice."3.77RGD-conjugated PLA-PLL nanoparticles targeting to Bacp-37 breast cancer xenografts in vivo. ( Duan, Y; Li, Y; Liu, P; Qi, X; Sun, Y; Wang, H, 2011)
"The aim of the present study was to develop nanoparticles of tamoxifen citrate, a non-steroidal antiestrogenic drug used for the treatment of breast cancer."3.76Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation. ( Basu, S; Mukherjee, B; Sahana, B; Santra, K, 2010)
"The aim of this work was to prepare paclitaxel-loaded PLGA nanoparticles and determine cytotoxicity of released paclitaxel for two hypoxic human tumor cell lines: breast carcinoma (MCF-7) and carcinoma cervicis (HeLa)."3.75Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells. ( Bai, L; Dou, K; Guo, G; Jin, C; Song, W; Wu, H, 2009)
" Two important determinants in this environment are hypoxia and lactic acidosis."3.74The genomic analysis of lactic acidosis and acidosis response in human cancers. ( Chen, JL; Chi, JT; Dewhirst, M; Lucas, JE; Mori, S; Nevins, J; Schroeder, T; West, M; Wu, J, 2008)
"This paper continued our earlier work on the poly(D,L-lactide-co-glycolide)/montmorillonite nanoparticles (PLGA/MMT NPs), which were further decorated by human epidermal growth factor receptor-2 (HER2) antibody Trastuzumab for targeted breast cancer chemotherapy with paclitaxel as a model anticancer drug."3.74Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer. ( Feng, SS; Ranganathan, B; Sun, B, 2008)
"The purpose of this study was to compare the combination (Paclitaxel + 5-FU microspheres) with a single drug chemotherapy (Paclitaxel and 5-FU microspheres) against metastatic breast cancer cell line (MDA-MB 435 S)."3.72Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres. ( Ciftci, K; Gupte, A, 2004)
"In MX1 human breast cancer xenografts grown on the hind paw of thymusaplastic nude mice the effect of ifosfamide on tumor oxygenation, tumor pH and the concentration of lactic acid have been determined at mean tumor temperatures of 32 degrees C, 37 degrees C and 41 degrees C."3.69The effect of ifosfamide on tumor oxygenation at different temperatures. ( Mendoza, AS; Mentzel, M; Wiedemann, G, 1994)
"The effects of 17 beta-estradiol treatment versus tamoxifen on the metabolism of human breast cancer T47D-clone 11 cells were studied by noninvasive 31P and 13C nuclear magnetic resonance techniques."3.67Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy. ( Degani, H; Neeman, M, 1989)
"MCT4 and Cav-1 are also breast cancer prognostic biomarkers."2.50Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. ( Lisanti, MP; Martinez-Outschoorn, U; Sotgia, F, 2014)
" Studies on the dosage design of this new delivery system of leuprorelin are summarized."2.38[Once-a-month injectable microcapsules of leuprorelin acetate]. ( Ogawa, Y; Okada, H; Toguchi, H; Yamamoto, M, 1991)
"Globally, breast cancer is one of the leading causes of cancer death in women."1.91Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer. ( Liu, L; Luo, D; Wang, C; Xue, L; Zhang, S; Zhu, W, 2023)
" The current research attempted to develop poly (lactic-co-glycolic acid) nanoparticles loaded with raloxifene by modified emulsification solvent diffusion evaporation method to improve oral bioavailability by using Taguchi design."1.91Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application. ( Gandhi, S; Kavisri, M; Maddiboyina, B; Moovendhan, M; Nakkala, RK; Roy, H, 2023)
"TIGAR downregulation in breast carcinoma cells reduces tumor growth."1.91TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer. ( Bartrons, R; Birbe, RC; Caro, J; Domingo-Vidal, M; Győrffy, B; Ko, YH; Lin, Z; Martinez-Outschoorn, U; Philp, NJ; Roche, ME; Tuluc, M; Whitaker-Menezes, D, 2023)
"GPR81 supports breast cancer aggressiveness, and in MCF-7 cells, this occurs at least in part via DLL4."1.91Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4. ( Blasco, LP; Dmytriyeva, O; Goncalves-Alves, E; Kveiborg, M; Lundø, K; Pedersen, SF; Ponniah, M; Sandelin, A; Schwartz, TW; Severin, M; Spøhr, L; Trauelsen, M; Yao, J, 2023)
"The first-line treatment of metastatic breast cancer in premenopausal women relies on tamoxifen."1.72Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen-resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C ( Albustanji, S; Alhusban, AA; Hamadneh, LA; Shallan, AI, 2022)
"Fifty-five matched breast cancer tissues and the para-carcinoma normal tissues were included in this study and used to verify TUBA1C expression using quantitative reverse transcription-PCR and western blotting."1.72Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer. ( Fan, R; Sun, S; Wang, Z; Wu, Z, 2022)
"Mechanistically, breast cancer cells with ectopic Zeb1 expression produce lactate in the acidic tumor milieu to induce the alternatively activated (M2) macrophage phenotype through stimulation of the PKA/CREB signaling pathway."1.72Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer. ( Chang, A; Jiang, H; Li, J; Ou, Y; Sun, W; Wang, H; Wang, W; Wang, Z; Wei, H; Xiao, X; Yang, S; Zhao, L, 2022)
"Knockdown of GPR81 decreased breast cancer cell proliferation, and tumor growth."1.72The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer. ( Hata, K; Hirose, K; Ishihara, S; Nishimura, R; Okui, T; Toyosawa, S; Uzawa, N; Yoneda, T, 2022)
"Tamoxifen is a widely used estrogen receptor inhibitor, whose clinical success is limited by the development of acquired resistance."1.72Lactate is a potential promoter of tamoxifen resistance in MCF7 cells. ( Di Stefano, G; Farabegoli, F; Govoni, M; Rossi, V, 2022)
"Also, treating mice with established breast tumors (4T1) using NPs loaded with siRNA molecules in combination with DC vaccine pulsed with tumor lysate significantly inhibited tumor growth and increased survival in mice."1.72Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model. ( Afsharimanesh, N; Barshidi, A; Ebrahimi, F; Hassannia, H; Hojjat-Farsangi, M; Jadidi-Niaragh, F; Jafari, R; Jalali, P; Karpisheh, V; Kiaie, SH; Kiani, FK; Mahmoodpoor, A; Mohammadi, M; Nami, S; Navashenaq, JG; Noukabadi, FK; Zolbanin, NM, 2022)
"However, its role in breast cancer cell glucose metabolism was unclear."1.62Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression. ( Fan, Y; Jin, F; Liang, X; Song, T; Su, D; Wang, J; Wang, Y; Xu, Y, 2021)
"Forty paired breast cancer tumor samples, the adjacent non-tumor and five healthy tissues were collected."1.62The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. ( Afkhami, H; Fathi, J; Khaledi, M; Moslemi, M; Nafissi, N; Rezaie, E; Sohrabi, E; Zekri, A, 2021)
"Twenty breast (58 ± 10 years) and 20 prostate cancer survivors (68 ± 6 years), 3."1.56Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO ( Rosenberger, F; Schlüter, K; Schneider, J; Sprave, T; Wiskemann, J, 2020)
"Hormone-dependent T-47D breast cancer cells were used."1.56Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer. ( Jeong, KY; Kim, HM; Lee, JK; Park, MH; Park, SY, 2020)
"Precision medicine in breast cancer demands markers sensitive to early treatment response."1.56Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy. ( Cheung, SM; He, J; Heys, SD; Husain, E; Masannat, Y; Miller, ID; Wahle, K, 2020)
"Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis."1.56Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics. ( Cheng, J; Dong, F; Gao, J; Guo, Z; Li, H; Sun, B; Wu, S; Yan, X; Yang, J, 2020)
"Our group recently showed in breast cancer patients that EGFR expression is strongly correlated with high tumor uptake of the glucose analogue, 18F-fluorodeoxyglucose (FDG)."1.51EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling. ( Cho, YS; Jung, KH; Lee, EJ; Lee, JH; Lee, KH; Moon, SH; Park, JW, 2019)
"Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation."1.48Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer. ( Grill, AE; Koniar, B; Panyam, J; Shahani, K, 2018)
"Breast cancer is one of the major causes of death in the USA."1.48Vitamin D ( Hussain, F; Khan, ZS; Munir, MT; Rahman, SM; Santos, JM; Tarafdar, K, 2018)
"Three breast cancer cell lines and immunocompetent and immunodeficient mice were used to evaluate the therapeutic effects of Rp plus ω-3 PUFA treatment."1.48Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death. ( Chen, W; Chen, YQ; Feng, N; He, Z; Jiang, X; Lin, G; Tong, Y; Wang, S; Yang, Q; Zhu, S, 2018)
"4T1 murine breast cancer cells were transfected with shRNA plasmids directed against LDH-A (KD) or a scrambled control plasmid (NC)."1.48LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response. ( Blasberg, R; Cohen, IJ; Khanin, R; Koutcher, JA; Maeda, M; Mane, M; Moroz, E; Satagopan, J; Serganova, I; Shindo, M; Vemuri, K, 2018)
"Paclitaxel (PTX) has been indicated for the treatment of a variety of solid tumors, whereas artesunate (ART) has been reported to have the potential for use in combination chemotherapy."1.46Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response. ( Kim, JO; Nguyen, CN; Nguyen, HT; Tran, BN; Yong, CS, 2017)
"Everolimus is a drug used successfully in a number of different oncology indications, but significant on-target toxicities exist."1.46Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer. ( Guthy, D; Laborde, L; McSheehy, P; Oz, F; Ristov, M; Sterker, D, 2017)
"The mechanisms underlying breast cancer chemoprevention by WA were elucidated by immunoblotting, biochemical assays, immunohistochemistry, and cytokine profiling using plasma and tumors from the MNU-rat (n = 8-12 for control group, n = 7-11 for 4 mg/kg group, and n = 8-12 for 8 mg/kg group) and/or mouse mammary tumor virus-neu (MMTV-neu) models (n = 4-11 for control group and n = 4-21 for 4 mg/kg group)."1.46Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A. ( Beumer, JH; Christner, SM; Davidson, NE; Hahm, ER; Kim, SH; Pore, SK; Roy, R; Samanta, SK; Sehrawat, A; Shuai, Y; Singh, KB; Singh, SV, 2017)
"Breast cancer is the leading cause of cancer-related deaths in women and earlier detection can substantially reduce deaths from breast cancer."1.46Synthesis, characterization, and in vitro evaluation of targeted gold nanoshelled poly(d,l-lactide-co-glycolide) nanoparticles carrying anti p53 antibody as a theranostic agent for ultrasound contrast imaging and photothermal therapy. ( Du, J; Li, F; Li, H; Liu, X; Wan, C; Xu, L; Yang, H, 2017)
"Chemoresistance in breast cancer is a major obstacle, especially in p53 mutation types."1.46l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis. ( Azadbakht, M; Jahani, M; Mansouri, K; Norooznezhad, F, 2017)
"Human breast tumors contain significant amounts of stromal cells."1.46Tumor stroma interaction is mediated by monocarboxylate metabolism. ( Ackerstaff, E; Banerjee, D; Blasberg, RG; Kerrigan, JE; Koutcher, JA; Patel, BB; Serganova, IS, 2017)
" The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPβCD (hydroxyl propyl beta cyclodextrin) and to assess its anti-cancer activity against breast cancer cells."1.46Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles. ( Bhandi, MM; Borkar, RM; Gudem, S; Kadari, A; Kolapalli, VR; Kulhari, H; Sistla, R, 2017)
"A treatment concept of blocking breast cancer cell migration from interaction with SDF- 1α by using LFC131-NPs and then attacking breast cancer cells with doxorubicin might increase the efficacy of current breast cancer treatment."1.46CXCR4-targeted Nanoparticles Reduce Cell Viability, Induce Apoptosis and Inhibit SDF-1α Induced BT-549-Luc Cell Migration In Vitro. ( Chittasupho, C; Kewsuwan, P; Murakami, T, 2017)
"Evodiamine (EVO) is a plant-derived indolequinazoline alkaloid with potential anticancer activity."1.43Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles. ( Bao, J; Chen, F; Chen, M; He, C; Wang, L; Wang, S; Wang, Y; Zou, L, 2016)
" The present work is aimed to enhance the bioavailability of etoposide by co-administering it with quercetin (a P-gp inhibitor) in dual-loaded polymeric nanoparticle formulation."1.43Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. ( Fatma, S; Goswami, DG; Iqbal, Z; Negi, LM; Panda, AK; Talegaonkar, S; Tariq, M, 2016)
"P-glycoprotein (P-gp) efflux is the major cause of multidrug resistance (MDR) in tumors when using anticancer drugs, moreover, poor bioavailability of few drugs is also due to P-gp efflux in the gut."1.43Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. ( Domb, AJ; Katiyar, SS; Khan, W; Muntimadugu, E; Rafeeqi, TA, 2016)
"Chrysin is a natural flavonoid which has been reported to have some significant biological effects on the processes of chemical defense, nitrogen fixation, inflammation, and oxidation."1.43Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line. ( Akbarzadeh, A; Anari, E; Zarghami, N, 2016)
"Human breast cancer MDA-MB-231 cell and mice MDA-MB-231 xenograft model were used for in vitro and in vivo evaluation."1.43Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid). ( Chen, Y; Hong, H; Li, Y; Liu, C; Qian, J; Wang, G; Wang, P; Wang, Y; Yu, B; Yuan, Y, 2016)
"The uptakes of NPs in human breast cancer MCF-7 cells were evaluated by the flow cytometry and the confocal microscope."1.43Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin. ( Cai, X; Chen, H; Jia, Y; Lv, F; Nan, W; Qin, J; Xie, LQ; Yang, W; Zhang, QQ, 2016)
"Paclitaxel (PTX) is an effective anticancer agent used in the therapy of a wide variety of cancers."1.43Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel. ( Chuttani, K; Ghanghoria, R; Jain, NK; Mishra, AK; Tekade, RK, 2016)
"In our current studies, using breast cancer cell lines, we determined the protective role of OA in high salt-mediated osmotic stress-induced cancer growth."1.43Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. ( Amara, S; Tiriveedhi, V; Zheng, M, 2016)
"Poly(lactic acid) (PLA) is a FDA-approved biomaterial displaying excellent biocompatibility and low toxicity."1.43Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer. ( Dai, Z; Du, Y; Jing, L; Li, X; Li, Y; Liang, X; Tian, J; Zhang, Q, 2016)
"T47D breast cancer cells were further evaluated for time-dependent and dose-dependent effects on (18)F-FDG uptake, lactate release, oxygen consumption rate (OCR), reactive oxygen species (ROS) production, and mitochondrial membrane potential."1.43Molecular mechanism of (18)F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism. ( Cho, YS; Choe, YS; Jung, KH; Lee, JH; Lee, KH; Moon, SH; Park, JW, 2016)
"Exercise decreases breast cancer risk and disease recurrence, but the underlying mechanisms are unknown."1.43Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses. ( Andersen, C; Christensen, JF; Dethlefsen, C; Hojman, P; Lillelund, C; Midtgaard, J; Pedersen, BK, 2016)
"Here, GPR81 expression in breast cancer patients and several breast cancer cell lines was significantly increased compared with normal mammary tissues and cells."1.43G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion. ( Heo, K; Lee, YJ; Noh, DY; Park, KS; Park, S; Park, SA; Ryu, SH; Seo, YK; Shin, KJ; Suh, PG, 2016)
"Fresh breast tumors were initially used to generate tumor lysate antigens containing poly lactic-co-glycolic acid (PLGA) NP."1.43Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens. ( Biparva, P; Delirezh, N; Iranpour, S; Nejati, V; Shirian, S, 2016)
"A subgroup of breast cancers has several metabolic compartments."1.43TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. ( Bartrons, R; Birbe, RC; Capparelli, C; Caro, J; Curry, JM; Domingo-Vidal, M; Ko, YH; Lin, Z; Manzano, A; Martinez-Outschoorn, U; Navarro-Sabaté, À; Roche, M; Seifert, E; Tassone, P; Tuluc, M; Whitaker-Menezes, D, 2016)
"Saquinavir (SQV) is a US-FDA approved HIV protease inhibitor (HPI) for HIV cure."1.42Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity. ( Banerjee, S; Jain, NK; Kesharwani, P; Mehra, NK; Singh, R; Singh, S, 2015)
"Breast cancer is the most common cancer in women worldwide."1.42Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells. ( Koyakutty, M; Menon, D; Mony, U; Narayanan, S; Paul-Prasanth, B; Vijaykumar, DK, 2015)
"MCT4 depletion reduced the ability of breast cancer cells to grow in a three-dimensional (3D) matrix or as multilayered spheroids."1.42Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. ( Baenke, F; Brault, C; Dankworth, B; Dubuis, S; Griffiths, B; Howell, M; Jiang, M; Mackay, A; Reis-Filho, JS; Ros, S; Saunders, B; Schulze, A; Spencer-Dene, B; Stamp, G; Weigelt, B; Zamboni, N, 2015)
"Cell studies using metastatic breast cancer cells demonstrated disruption of Src kinase involved in the cancer migration by albumin-dasatinib nano-shell and generation of photoactivated oxidative stress by mTHPC-PLGA nano-core."1.40A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing. ( Chandran, P; Gupta, N; Koyakutty, M; Malarvizhi, GL; Nair, S; Ramachandran, R; Retnakumari, AP, 2014)
"Multidrug-resistant breast cancers have limited and ineffective clinical treatment options."1.40Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model. ( Chen, Y; Fang, DL; Lei, Y; Li, HL; Ren, K; Song, XR; Xu, B; Yang, Y; Zhang, JK; Zheng, XL, 2014)
" Promising properties, including long-circulation time, enhanced tumor localization, interference with "multidrug" resistance effects, and environmental biodegradability, often result in an improvement of the drug bioavailability and effectiveness."1.40Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells. ( Colombo, M; Corsi, F; Gramatica, F; Marinozzi, MR; Mazzucchelli, S; Morasso, C; Pandolfi, L; Prosperi, D; Vanna, R; Verderio, P, 2014)
" At the same time, higher Caco-2 cell uptake revealed its potential for oral delivery, which was well corroborated with in vivo pharmacokinetics, which suggested ∼ 5-fold and ∼ 3-fold increase in oral bioavailability as compared to the free Tmx citrate and free QT, respectively."1.39Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. ( Jain, AK; Jain, S; Thanki, K, 2013)
"This study showed that breast cancer cells tolerate and use lactate at clinically relevant concentrations in vitro (± glucose) and in vivo."1.39Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. ( Chi, JT; Dewhirst, MW; Kennedy, KM; Landon, CD; Pizzo, S; Ribeiro, A; Richardson, R; Scarbrough, PM; Schroeder, T; Sonveaux, P; Yuan, H, 2013)
"The production of lactate by T47D breast cancer cells can be characterized by Michaelis-Menten-like kinetics, with K(m) = 3."1.39Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures. ( Degani, H; Frydman, L; Harris, T, 2013)
"Fatigue is one of the most commonly reported side effects during treatment for breast cancer and can persist following treatment completion."1.39Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors. ( Campbell, KL; Garland, SJ; Klika, RJ; McKenzie, DC; Neil, SE, 2013)
" PLGA nanoparticles proved to be completely safe, suggesting a potential utilization of this nanocomplex to improve the intrinsically poor bioavailability of curcumin for the treatment of severe malignant breast cancer."1.39Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells. ( Bonetti, P; Colombo, M; Pandolfi, L; Prosperi, D; Verderio, P, 2013)
"We have shown earlier that breast cancer cells secrete higher levels of interleukin-6 (IL-6) under hypoxia, leading to the recruitment of hMSCs towards hypoxic tumor cells."1.38Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. ( Ackerstaff, E; Banerjee, D; Glod, JW; Koutcher, JA; Patel, BB; Rattigan, YI; Sukenick, G, 2012)
"Perifosine is an anticancer alkylphospholipid used in clinical trials."1.38Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells. ( Ronen, SM; Su, JS; Woods, SM, 2012)
"Our results showed that the three breast cancer cell lines used presented different sensitivities to 3-BP: ZR-75-1 ER (+)>MCF-7 ER (+)>SK-BR-3 ER (-)."1.38Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. ( Azevedo-Silva, J; Baltazar, F; Casal, M; Ko, YH; Moreira, R; Pacheco, A; Pedersen, PL; Pedro, M; Pinheiro, C; Preto, A; Queirós, O, 2012)
"Biopsies from breast cancer patients (n=98) were excised during surgery and analyzed by high-resolution magic angle spinning MRS."1.38Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers. ( Bathen, TF; Buydens, LM; Fjøsne, HE; Giskeødegård, GF; Gribbestad, IS; Lundgren, S; Postma, G; Sitter, B, 2012)
"Conversely, we generated human breast cancer cells (MDA-MB-231 cells) overexpressing CDK inhibitors, namely p16(INK4A) or p21(WAF1/CIP1)."1.38CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. ( Andò, S; Capparelli, C; Chiavarina, B; Howell, A; Hulit, J; Lisanti, MP; Martinez-Outschoorn, UE; Pestell, RG; Pestell, TG; Sotgia, F; Whitaker-Menezes, D, 2012)
"Finally, using human breast cancer tumor samples, we directly confirmed that the enzymes associated with ketone body production (HMGCS2, HMGCL and BDH1) were preferentially expressed in the tumor stroma."1.38Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. ( Howell, A; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Sotgia, F; Whitaker-Menezes, D, 2012)
" Oral bioavailability of Tmx was increased by 3."1.37The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen. ( Godugu, C; Jain, AK; Jain, S; Singh, RP; Swarnakar, NK, 2011)
"Posttreated patients with breast cancer were matched with healthy women based on age, physical fitness level, and menopausal status."1.37Exercise in patients with breast cancer and healthy controls: energy substrate oxidation and blood lactate responses. ( Battaglini, CL; Evans, ES; Groff, D; Hackney, AC; Tosti, KP, 2011)
"Briefly, human breast cancer cells (MCF7) were cultured with lactate or ketones, and then subjected to transcriptional analysis (exon-array)."1.37Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. ( Ertel, A; Flomenberg, N; Howell, A; Knudsen, ES; Lin, Z; Lisanti, MP; Martinez-Outschoorn, UE; Pavlides, S; Pestell, RG; Prisco, M; Sotgia, F; Tsirigos, A; Wang, C, 2011)
"The human breast cancer tissues showed a close correlation between KLF4 and PFKP expression."1.37Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer. ( Jin, WJ; Kim, HE; Kim, KS; Koh, E; Moon, JS; Park, BW; Park, SH; Park, SW, 2011)
"Treatment with curcumin microparticles resulted in diminished vascular endothelial growth factor expression and poorly developed tumor microvessels, indicating a significant effect on tumor angiogenesis."1.36Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. ( Blum, A; Freeman, D; Ma, L; Panyam, J; Shahani, K; Swaminathan, SK, 2010)
"MCF-7 breast cancer cells were employed to evaluate the cellular uptake and cytotoxicity."1.36Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: effects of surfactants on particles size, characteristics and in vitro performance. ( Feng, SS; Liu, Y; Pan, J, 2010)
"To improve the encapsulation efficiency and oral bioavailability of vincristine sulfate (VCR), novel self-assembled dextran sulphate-PLGA hybrid nanoparticles (DPNs) were successfully developed using self-assembly and nanoprecipitation method."1.36Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition. ( Deng, Y; He, Z; Ling, G; Meng, X; Qin, Y; Sun, J; Zhang, P; Zhang, W, 2010)
"Similar to in vivo FdG-PET or primary breast cancers, rates of glycolysis were diverse, being higher in cells expressing both c-Myc and HIF-1alpha and lower in cell lines low or negative in both transcription factors."1.35Regulation of the Warburg effect in early-passage breast cancer cells. ( Baggett, BK; Brown, KS; Gatenby, RA; Gillies, RJ; Robey, IF; Stephen, RM, 2008)
"In vitro toxicity in MDA-MB-231 breast cancer cells of the surface-adsorbed and shell-incorporated doxorubicin (Dox) loaded UCA were examined at 5 MHz insonation using a pulse repetition frequency of 100 Hz at varying pressure amplitudes."1.35Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents. ( Eisenbrey, JR; Hsu, J; Huang, P; Wheatley, MA, 2009)
"Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity and poor bioavailability of antineoplastic drugs."1.35Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy. ( Acharya, S; Dilnawaz, F; Sahoo, SK, 2009)
"Co-culture of human breast carcinoma cells (MCF-7) with paclitaxel-loaded nanoparticles demonstrated that released paclitaxel retained its bioactivity to block cells in the G2/M phase of the cell cycle and effectively sensitized hypoxic MCF-7 cells to radiation with radiosensitivity shown to be dependent of radiation dose at levels of dosages studied."1.34The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells. ( Bai, L; Guo, G; Jin, C; Liu, J; Wu, H, 2007)
"Clotrimazole is an anti-fungal azole derivative recently recognized as a calmodulin antagonist with promising anti-cancer effect."1.33Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes. ( Da Poian, AT; de Freitas, MS; Holandino, C; Marinho-Carvalho, MM; Meira, DD; Sola-Penna, M; Teixeira, CA; Veiga, VF, 2005)
"Gemcitabine was infused into a central reservoir."1.33Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens. ( Brundage, RC; Elmquist, WF; Guire, DE; Kirstein, MN; Marker, PH; Remmel, RP; Yee, D, 2006)
"The observed dependence of breast cancer cells on pentose phosphate pathway activity and glutamine consumption for estradiol-stimulated biosynthesis suggests that these pathways may be targets for estrogen-independent breast cancer therapies."1.33Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. ( Blanch, HW; Clark, DS; Forbes, NS; Meadows, AL, 2006)
"Therefore, human breast cancer presents metabolic microregions."1.32Metabolism of the microregions of human breast cancer. ( Borges, JB; Curi, R; de Almeida, DC; dos Santos, MA, 2004)
"This method was applied in MCF7 human breast cancer implanted in the mammary gland of female CD1-NU mice and was further employed to assess tumor response to hormonal manipulation with the antiestrogen tamoxifen."1.31Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS. ( Degani, H; Margalit, R; Rivenzon-Segal, D, 2002)
"Metastatic breast cancer cells from pleural effusions were up to 200-fold more active in acidifying their extracellular milieu than non-malignant mammary cells cultured in the same conditions, strongly suggesting that this difference also occurs in vivo."1.30Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism. ( Bird, I; Farnoud, R; Montcourrier, P; Rochefort, H; Silver, I, 1997)
"In MCF-7 human breast cancer cells, both TCDD and TPA inhibited constitutive and 17 beta-estradiol-induced cell proliferation but showed no apparent interactive effects."1.29Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells. ( Krishnan, V; Moore, M; Narasimhan, TR; Safe, S; Scott, AI; Wang, X; Williams, HJ, 1993)
"For the treatment of malignant pleural effusions, we prepared doxorubicin hydrochloride (Adriamycin)-containing poly(L-lactic acid) microspheres (ADR-MS)."1.28Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres. ( Hitomi, S; Ikada, Y; Ike, O; Shimizu, Y; Wada, R, 1991)
"and/or "tissue-isolated" human breast cancer xenografts in T-cell-deficient rnu/rnu rats."1.27Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats. ( Baessler, KH; Berg, G; Fortmeyer, HP; Kallinowski, F; Mueller-Klieser, W; Runkel, S; Vaupel, P; Wagner, K; Walenta, S, 1988)
"The glucose uptake rate of human mammary carcinomas transplanted into nude rats is comparable to values obtained in isotransplanted rodent tumors."1.27Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo. ( Baessler, KH; Davel, S; Kallinowskil, F; Vaupell, P; Wagner, K, 1985)

Research

Studies (308)

TimeframeStudies, this research(%)All Research%
pre-19904 (1.30)18.7374
1990's7 (2.27)18.2507
2000's36 (11.69)29.6817
2010's216 (70.13)24.3611
2020's45 (14.61)2.80

Authors

AuthorsStudies
Yang, J4
Davis, T1
Kazerouni, AS1
Chen, YI1
Bloom, MJ1
Yeh, HC1
Yankeelov, TE1
Virostko, J1
Alhusban, AA2
Hamadneh, LA1
Albustanji, S2
Shallan, AI1
Karoon Kiani, F3
Izadi, S2
Ansari Dezfouli, E1
Ebrahimi, F2
Mohammadi, M2
Chalajour, H1
Mortazavi Bulus, M1
Nasr Esfahani, M1
Karpisheh, V2
Mahmoud Salehi Khesht, A1
Abbaszadeh-Goudarzi, K1
Soleimani, A1
Gholizadeh Navashenaq, J1
Ahmadi, M1
Hassannia, H6
Hojjat-Farsangi, M4
Shahmohammadi Farid, S1
Hashemi, V1
Jadidi-Niaragh, F6
Wu, Z2
Sun, S1
Fan, R1
Wang, Z8
Hao, Q1
Huang, Z2
Li, Q3
Liu, D1
Wang, P2
Wang, K1
Li, J6
Cao, W1
Deng, W1
Wu, K1
Su, R1
Liu, Z4
Vadgama, J1
Wu, Y2
Jiang, H1
Wei, H1
Wang, H7
Ou, Y1
Xiao, X1
Wang, W2
Chang, A1
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Nguyen, VD1
Park, JO1
Park, SH2
Min, JJ1
Park, IK1
Babahosseini, H1
Srinivasaraghavan, V1
Zhao, Z1
Gillam, F1
Childress, E1
Strobl, JS1
Santos, WL1
Agah, M1
Yu, K1
Zhang, Z2
Gao, Y2
Teng, L1
Xie, LQ1
Jia, Y1
Cai, X1
Nan, W1
Yang, W1
Lv, F1
Zhang, QQ1
Rastegari, A2
Mollarazi, E1
Kiani, M1
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Kheshtchin, N2
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Shokri, F2
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Araújo, JR1
Gregório, I1
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Yan, D1
Keidar, M1
Zhang, LG1
Xu, CF1
Zhang, HB1
Sun, CY1
Shen, S2
Yang, XZ1
Zhu, YH1
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Lucas, JE1
Mori, S1
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Wang, R1
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Jin, C2
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Eisenbrey, JR1
Huang, P1
Hsu, J1
Wheatley, MA2
Kos, J2
Obermajer, N2
Doljak, B1
Kocbek, P2
Kristl, J2
Yu, M1
Shi, Y1
Wei, X1
Zang, F1
Niu, R1
Acharya, S1
Dilnawaz, F1
Palmer, GM1
Fraser, CL1
Liu, H1
Ding, Y1
Khong, HT1
Yu, D1
Fodstad, O1
Tan, M1
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Zheng, Y2
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Piao, L1
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Mao, Y1
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Sugimoto, Y1
Brueggemeier, RW1
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Feng, SS4
Sedoris, KC1
Thomas, SD1
Miller, DM1
Swaminathan, SK1
Freeman, D1
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Ma, L1
Pamujula, S1
Hazari, S1
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Graves, RA1
Chinta, DM1
Dash, S1
Kishore, V1
Mandal, TK1
Ling, G1
Zhang, P1
Zhang, W1
Meng, X1
Qin, Y1
Deng, Y1
Martinez-Outschoorn, UE10
Balliet, RM2
Rivadeneira, DB1
Chiavarina, B6
Pavlides, S4
Daumer, KM1
Witkiewicz, AK3
Flomenberg, N4
Howell, A10
Pestell, RG9
Knudsen, ES2
Bonuccelli, G1
Tsirigos, A2
Frank, PG1
Sahana, B1
Santra, K1
Basu, S1
Swarnakar, NK2
Godugu, C2
Singh, RP2
Varghese, B1
Swaminathan, G1
Plotnikov, A1
Tzimas, C1
Yang, N1
Rui, H1
Fuchs, SY1
Tosti, KP1
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Yadav, AK1
Agarwal, A1
Bid, H1
Rai, G1
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Agrawal, GP1
Mishra, D1
Kang, HC1
Bae, YH2
Shieh, MJ1
Hsu, CY1
Huang, LY1
Chen, HY1
Huang, FH1
Lai, PS1
Grinde, MT1
Moestue, SA1
Borgan, E1
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Gribbestad, IS2
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Trembleau, L1
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Kim, HE1
Koh, E1
Jin, WJ1
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Glod, JW1
Birbe, R1
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Su, JS1
Woods, SM2
Ronen, SM2
Li, B1
Yao, M1
Xie, M1
Shen, H2
Jin, Y1
Dasgupta, A1
Gandara, R1
Sneddon, S1
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Preto, A1
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Pinheiro, C2
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Moreira, R1
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Baltazar, F2
Casal, M1
Saxena, V1
Naguib, Y1
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Giskeødegård, GF1
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Postma, G1
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Bathen, TF1
Qi, X1
Duan, Y1
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Kou, G1
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Moore, M1
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Krishnan, V1
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Scott, AI1
Montcourrier, P1
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Malm, M1
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Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Feasibility and Preliminary Efficacy of Aerobic Exercise in Head and Neck Cancer Patients Undergoing Radiation Therapy[NCT04679233]0 participants (Actual)Interventional2021-02-28Withdrawn (stopped due to PI has withdrawn from the program, the study never started.)
Clinical and Functional Variables in the Assessment of Oncology Patient[NCT03879096]120 participants (Actual)Interventional2016-05-01Completed
Trial of Dichloroacetate (DCA) in Glioblastoma Multiforme (GBM)[NCT05120284]Phase 240 participants (Anticipated)Interventional2022-07-01Recruiting
Feasibility of Monitoring of Bone Free Flaps With Microdialysis Catheter Directly Positioned in Bone Tissue[NCT01879384]34 participants (Actual)Interventional2011-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for lactic acid and Breast Neoplasms

ArticleYear
Hyperpolarised
    European journal of radiology, 2023, Volume: 167

    Topics: Breast; Breast Neoplasms; Female; Humans; Lactic Acid; Magnetic Resonance Imaging; Pyruvic Acid

2023
The Significance of Microenvironmental and Circulating Lactate in Breast Cancer.
    International journal of molecular sciences, 2023, Oct-19, Volume: 24, Issue:20

    Topics: Breast Neoplasms; Female; Glucose; Glycolysis; Humans; Lactic Acid

2023
Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function.
    Seminars in oncology, 2014, Volume: 41, Issue:2

    Topics: Animals; Autophagy; Breast Neoplasms; Cachexia; Carcinoma; Caveolin 1; Cell Line, Tumor; Cell Transf

2014
Effect of polyphenols on glucose and lactate transport by breast cancer cells.
    Breast cancer research and treatment, 2016, Volume: 157, Issue:1

    Topics: Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expres

2016
Predicting tumour response to anti-HER1 therapy using medical imaging: a literature review and in vitro study of [18F]-FDG incorporation by breast cancer cells responding to cetuximab.
    British journal of biomedical science, 2011, Volume: 68, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms;

2011
[Once-a-month injectable microcapsules of leuprorelin acetate].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1991, Volume: 111, Issue:8

    Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Capsules; Delayed-Action Preparations; Drug Delivery

1991

Trials

2 trials available for lactic acid and Breast Neoplasms

ArticleYear
[Therapeutic evaluation of the polylactic acid gel (PLA-G) used for preventing skin flap adhesion in modified radical mastectomy].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2013, Volume: 30, Issue:6

    Topics: Breast Neoplasms; Drainage; Female; Gels; Humans; Lactic Acid; Mastectomy, Modified Radical; Necrosi

2013
Aerobic exercise intensity in breast cancer patients: a preliminary investigation.
    Integrative cancer therapies, 2009, Volume: 8, Issue:2

    Topics: Adult; Breast Neoplasms; Case-Control Studies; Exercise; Exercise Test; Female; Heart Rate; Humans;

2009

Other Studies

300 other studies available for lactic acid and Breast Neoplasms

ArticleYear
Longitudinal FRET Imaging of Glucose and Lactate Dynamics and Response to Therapy in Breast Cancer Cells.
    Molecular imaging and biology, 2022, Volume: 24, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Fluorescence Resonance Energy Transfer; Glucose; Humans;

2022
Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen-resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C
    Electrophoresis, 2022, Volume: 43, Issue:3

    Topics: Breast Neoplasms; Electric Conductivity; Electrophoresis, Capillary; Female; Gene Expression; Glucos

2022
Simultaneous silencing of the A2aR and PD-1 immune checkpoints by siRNA-loaded nanoparticles enhances the immunotherapeutic potential of dendritic cell vaccine in tumor experimental models.
    Life sciences, 2022, Jan-01, Volume: 288

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Chitosan; Colorectal Neoplasms; Combined M

2022
Tubulin alpha 1c promotes aerobic glycolysis and cell growth through upregulation of yes association protein expression in breast cancer.
    Anti-cancer drugs, 2022, 02-01, Volume: 33, Issue:2

    Topics: Adenosine Triphosphate; Adult; Aged; Animals; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell P

2022
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022, Volume: 9, Issue:6

    Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea

2022
Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer.
    Cell death & disease, 2022, 03-04, Volume: 13, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Lactic Acid; Macrophages; Phosphatid

2022
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
    Journal of pharmaceutical and biomedical analysis, 2022, May-30, Volume: 214

    Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine;

2022
TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
    Anti-cancer drugs, 2022, 06-01, Volume: 33, Issue:5

    Topics: Breast Neoplasms; Calcineurin; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hypoxia; Lactic

2022
The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer.
    Scientific reports, 2022, 04-15, Volume: 12, Issue:1

    Topics: Breast Neoplasms; Female; Glycolysis; Humans; Lactic Acid; Receptors, G-Protein-Coupled; Tumor Micro

2022
A deep tumor penetration nanoplatform for glycolysis inhibition and antimetastasis of breast cancer.
    Journal of materials chemistry. B, 2022, 06-08, Volume: 10, Issue:22

    Topics: Breast Neoplasms; Cell Line, Tumor; Edetic Acid; Female; Folic Acid; Glycolysis; Humans; Indocyanine

2022
Lactate is a potential promoter of tamoxifen resistance in MCF7 cells.
    Biochimica et biophysica acta. General subjects, 2022, Volume: 1866, Issue:9

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Lactic

2022
Design and evaluation of hyaluronic acid-coated PLGA nanoparticles of raloxifene hydrochloride for treatment of breast cancer.
    Drug development and industrial pharmacy, 2021, Volume: 47, Issue:12

    Topics: Breast Neoplasms; Drug Carriers; Female; Humans; Hyaluronic Acid; Lactic Acid; Nanoparticles; Partic

2021
Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model.
    Pharmaceutical research, 2022, Volume: 39, Issue:8

    Topics: Animals; Antigens, CD; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Dendritic Cells; Immune

2022
Lactate receptor HCAR1 regulates cell growth, metastasis and maintenance of cancer‑specific energy metabolism in breast cancer cells.
    Molecular medicine reports, 2022, Volume: 26, Issue:2

    Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Energy Metabolism; Female; Glycolysis; Hu

2022
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles.
    Pharmaceutical development and technology, 2022, Volume: 27, Issue:7

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Emulsions; Femal

2022
Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer.
    Cancer immunology, immunotherapy : CII, 2023, Volume: 72, Issue:6

    Topics: Breast Neoplasms; Female; Glycolysis; Humans; Lactic Acid; Macrophage Activation; Macrophages

2023
Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application.
    Chemical biology & drug design, 2023, Volume: 102, Issue:3

    Topics: Breast Neoplasms; Drug Carriers; Female; Humans; Lactic Acid; Nanoparticles; Particle Size; Polyglyc

2023
Payload Release Profile and Anti-Cancer Stem Cell Properties of Compositionally Different Polymeric Nanoparticles Containing a Copper(II) Complex.
    Molecules (Basel, Switzerland), 2023, Mar-09, Volume: 28, Issue:6

    Topics: Breast Neoplasms; Copper; Drug Carriers; Female; Humans; Lactic Acid; Nanoparticles; Neoplasm Recurr

2023
TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer.
    International journal of cancer, 2023, 11-01, Volume: 153, Issue:9

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Female; Gly

2023
Multispectral Imaging of Metabolic Fluorophores: Comparing In Vivo and Fresh Ex Vivo Tissue.
    Critical reviews in eukaryotic gene expression, 2024, Volume: 34, Issue:1

    Topics: Animals; Breast Neoplasms; Female; Flavin-Adenine Dinucleotide; Humans; Lactic Acid; Mice; NAD

2024
Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer.
    BMC medical genomics, 2023, 11-10, Volume: 16, Issue:1

    Topics: Breast Neoplasms; Female; Histones; Humans; Immunotherapy; Lactic Acid; Lysine; Neoplasms; Prognosis

2023
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4.
    BMC cancer, 2023, Nov-22, Volume: 23, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Breast Neoplasms; Calcium-Binding Proteins; Female; Humans; La

2023
The effect of lactate dehydrogenase inhibitors on proliferation, motility and invasion of breast cancer cells
    Molecular medicine reports, 2024, Volume: 29, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Humans; L-Lactate Deh

2024
Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Animals; Breast Neoplasms; Cellular Reprogramming; Dendritic Cells; Female; Humans; Lactic Acid; Mic

2019
EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Fluorodeoxyglucose F

2019
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors.
    Medicine and science in sports and exercise, 2019, Volume: 51, Issue:12

    Topics: Aged; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Energy Metabolism; Exercise Test;

2019
Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines.
    Cellular and molecular biology (Noisy-le-Grand, France), 2019, Sep-30, Volume: 65, Issue:7

    Topics: Adenosine Triphosphate; Aminopyridines; Blotting, Western; Breast Neoplasms; Carrier Proteins; Cell

2019
The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment.
    Oncogene, 2020, Volume: 39, Issue:16

    Topics: Animals; Antigen-Presenting Cells; Breast Neoplasms; Cell Proliferation; Cyclic AMP; Dendritic Cells

2020
Exercise intensity prescription in cancer survivors: ventilatory and lactate thresholds are useful submaximal alternatives to VO
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020, Volume: 28, Issue:11

    Topics: Aged; Anaerobic Threshold; Breast Neoplasms; Cancer Survivors; Cross-Sectional Studies; Exercise Tes

2020
Potential Anticancer Effect of Calcium-mediated Src Degradation on Hormone-dependent Breast Cancer.
    Anticancer research, 2020, Volume: 40, Issue:4

    Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Female; Humans; Lactic Acid; Neoplasms, Hormone-Depende

2020
Why Warburg Works: Lactate Controls Immune Evasion through GPR81.
    Cell metabolism, 2020, 04-07, Volume: 31, Issue:4

    Topics: Antigen-Presenting Cells; Breast Neoplasms; Humans; Immune Evasion; Lactic Acid; Receptors, G-Protei

2020
Lactate concentration in breast cancer using advanced magnetic resonance spectroscopy.
    British journal of cancer, 2020, Volume: 123, Issue:2

    Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Female; Glycolysis; Humans; Lactate Dehydrogenase

2020
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.
    Cell reports, 2020, 06-02, Volume: 31, Issue:9

    Topics: Actins; Animals; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Epigenomics; Fem

2020
Silencing adenosine A2a receptor enhances dendritic cell-based cancer immunotherapy.
    Nanomedicine : nanotechnology, biology, and medicine, 2020, Volume: 29

    Topics: Adenosine A2 Receptor Antagonists; Animals; Breast Neoplasms; Cancer Vaccines; CD8-Positive T-Lympho

2020
Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation.
    Angewandte Chemie (International ed. in English), 2020, 12-01, Volume: 59, Issue:49

    Topics: Angiogenesis Inhibitors; Animals; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Cell Line

2020
Codelivery of BV6 and anti-IL6 siRNA by hyaluronate-conjugated PEG-chitosan-lactate nanoparticles inhibits tumor progression.
    Life sciences, 2020, Nov-01, Volume: 260

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chick Embryo; Chitosan; Colonic

2020
Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer.
    Cancer cell, 2020, 10-12, Volume: 38, Issue:4

    Topics: Breast Neoplasms; Forkhead Box Protein M1; Humans; Lactic Acid; Phosphatidylinositol 3-Kinases; Prot

2020
Effect of Doxorubicin on Myocardial Bicarbonate Production From Pyruvate Dehydrogenase in Women With Breast Cancer.
    Circulation research, 2020, 12-04, Volume: 127, Issue:12

    Topics: Adult; Antibiotics, Antineoplastic; Bicarbonates; Breast Neoplasms; Carbon-13 Magnetic Resonance Spe

2020
Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells.
    Biochemical and biophysical research communications, 2020, 12-17, Volume: 533, Issue:4

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Glucose; Glycoly

2020
Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics.
    Scientific reports, 2020, 12-15, Volume: 10, Issue:1

    Topics: Acidosis; Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Isotopes; Lactic Acid; Met

2020
Lactate Metabolism in Breast Cancer Microenvironment: Contribution Focused on Associated Adipose Tissue and Obesity.
    International journal of molecular sciences, 2020, Dec-18, Volume: 21, Issue:24

    Topics: Adipose Tissue; Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Follow-Up Studies; Human

2020
Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression.
    Cell communication and signaling : CCS, 2021, 02-15, Volume: 19, Issue:1

    Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Dis

2021
Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
    The FEBS journal, 2021, Volume: 288, Issue:19

    Topics: Animals; Breast; Breast Neoplasms; Carcinogenesis; Cell Proliferation; Epidermal Growth Factor; Epit

2021
Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line.
    Genes, 2021, 05-19, Volume: 12, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Express

2021
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer.
    Genes & genomics, 2021, Volume: 43, Issue:9

    Topics: Adult; Aged; Breast Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; L-Lactate Deh

2021
Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids.
    Molecular pharmaceutics, 2021, 08-02, Volume: 18, Issue:8

    Topics: Adaptive Immunity; Adenosine; Adoptive Transfer; Breast Neoplasms; Cell Hypoxia; Female; Humans; Hyd

2021
LncRNA SNHG5 promotes the glycolysis and proliferation of breast cancer cell through regulating BACH1 via targeting miR-299.
    Breast cancer (Tokyo, Japan), 2022, Volume: 29, Issue:1

    Topics: Basic-Leucine Zipper Transcription Factors; Breast Neoplasms; Cell Proliferation; Female; G1 Phase;

2022
Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.
    Anticancer research, 2017, Volume: 37, Issue:3

    Topics: Adenosine Triphosphate; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Female;

2017
Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway.
    International journal of pharmaceutics, 2017, May-15, Volume: 523, Issue:1

    Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Mo

2017
A novel long-acting biodegradable depot formulation of anastrozole for breast cancer therapy.
    Materials science & engineering. C, Materials for biological applications, 2017, Jun-01, Volume: 75

    Topics: Absorbable Implants; Anastrozole; Animals; Breast Neoplasms; Drug Implants; Female; Humans; Lactic A

2017
Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer.
    Drug delivery and translational research, 2018, Volume: 8, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Breast Neoplasms; Cell Proliferation; Curcumin; Cytokines; Delayed

2018
miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.
    Cancer letters, 2017, 08-01, Volume: 400

    Topics: 3' Untranslated Regions; Animals; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Movement;

2017
[Heregulin-β1-induced Glycolysis Promotes Migration of Breast Cancer Cell Line MCF7].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2016, Volume: 47, Issue:4

    Topics: Breast Neoplasms; Cell Movement; Glucose; Glycolysis; Humans; Isoenzymes; L-Lactate Dehydrogenase; L

2016
Developing combination of artesunate with paclitaxel loaded into poly-d,l-lactic-co-glycolic acid nanoparticle for systemic delivery to exhibit synergic chemotherapeutic response.
    Drug development and industrial pharmacy, 2017, Volume: 43, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Breast Neoplasms; Cell Line, Tumor; Drug

2017
Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer.
    Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Chr

2017
Nanoparticle-based delivery of an anti-proliferative metal chelator to tumor cells.
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2017, Volume: 2017

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chelating Agents; Humans; Iron; Lactic

2017
Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1α and Nuclear p65 (Rel A).
    Current drug delivery, 2018, Feb-14, Volume: 15, Issue:2

    Topics: A549 Cells; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Drug Carriers; Huma

2018
The in vitro study of Her-2 targeted gold nanoshell liquid fluorocarbon poly lactic-co-glycolic acid ultrasound microcapsule for ultrasound imaging and breast tumor photothermal therapy.
    Journal of biomaterials science. Polymer edition, 2018, Volume: 29, Issue:1

    Topics: Breast Neoplasms; Capsules; Cell Line, Tumor; Cell Survival; Contrast Media; Female; Flow Cytometry;

2018
Sustained Release Talazoparib Implants for Localized Treatment of
    Theranostics, 2017, Volume: 7, Issue:17

    Topics: Animals; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Female; Lactic Acid; Mice; Microscopy, E

2017
Glycol chitosan assisted in situ reduction of gold on polymeric template for anti-cancer theranostics.
    International journal of biological macromolecules, 2018, Apr-15, Volume: 110

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chitosan; Female; Gold; Humans; Hyperthermia, Indu

2018
Vitamin D
    The Journal of nutritional biochemistry, 2018, Volume: 53

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Survival; Cholecalciferol; Enzyme

2018
The FAQUIRE Approach: FAst, QUantitative, hIghly Resolved and sEnsitivity Enhanced
    Analytical chemistry, 2018, 02-06, Volume: 90, Issue:3

    Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor; Choline; Female; Humans; Hydrogen;

2018
Targeted Nanocurcumin Therapy Using Annexin A2 Anitbody Improves Tumor Accumulation and Therapeutic Efficacy Against Highly Metastatic Breast Cancer.
    Journal of biomedical nanotechnology, 2016, Volume: 12, Issue:7

    Topics: Animals; Annexin A2; Antibodies, Monoclonal; Breast Neoplasms; Cell Line, Tumor; Curcumin; Female; H

2016
Simultaneous Targeting of Differentiated Breast Cancer Cells and Breast Cancer Stem Cells by Combination of Docetaxel- and Sulforaphane-Loaded Self-Assembled Poly(D, L-lactide-co-glycolide)/Hyaluronic Acid Block Copolymer-Based Nanoparticles.
    Journal of biomedical nanotechnology, 2016, Volume: 12, Issue:7

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Docetaxel; Drug C

2016
The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer.
    Food & function, 2018, Feb-21, Volume: 9, Issue:2

    Topics: Amine Oxidase (Copper-Containing); Animals; Bacteria; Breast Neoplasms; Claudin-1; Claudins; Female;

2018
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
    Die Pharmazie, 2017, Sep-01, Volume: 72, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu

2017
Chitosan Stabilized Gold-Folate-Poly(lactide-co-glycolide) Nanoplexes Facilitate Efficient Gene Delivery in Hepatic and Breast Cancer Cells.
    Journal of nanoscience and nanotechnology, 2018, Jul-01, Volume: 18, Issue:7

    Topics: Breast Neoplasms; Chitosan; Female; Folic Acid; Genetic Therapy; Gold; Humans; Lactic Acid; Nanopart

2018
Functionalized Magnetic PLGA Nanospheres for Targeting and Bioimaging of Breast Cancer.
    Journal of nanoscience and nanotechnology, 2018, Mar-01, Volume: 18, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Contrast Media; Humans; Lactic Acid; Magnetic Resonance Imaging;

2018
Preparation of PLGA/Rose Bengal colloidal particles by double emulsion and layer-by-layer for breast cancer treatment.
    Journal of colloid and interface science, 2018, May-15, Volume: 518

    Topics: Adsorption; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Su

2018
Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer.
    Cell cycle (Georgetown, Tex.), 2018, Volume: 17, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Extracellular Signal

2018
Investigation of antitumor activities of trastuzumab delivered by PLGA nanoparticles.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Antineoplastic Agents, Immunological; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Libera

2018
Preparation and Imaging Investigation of Dual-targeted C
    Scientific reports, 2018, 03-01, Volume: 8, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Female; Fluorocarbons; Humans; Lactic A

2018
Muscular endurance and progression rates of early-stage invasive ductal carcinoma: A pilot study.
    The breast journal, 2018, Volume: 24, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Case-Control Studies; Disease Progression;

2018
Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using gold nanoshelled poly(lactic-co-glycolic acid) nanocapsules: a novel dual-targeted ultrasound contrast agent.
    International journal of nanomedicine, 2018, Volume: 13

    Topics: Animals; Antibodies; Breast Neoplasms; Contrast Media; Female; Gold; Humans; Lactic Acid; MCF-7 Cell

2018
Preparation of psoralen polymer-lipid hybrid nanoparticles and their reversal of multidrug resistance in MCF-7/ADR cells.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Chemist

2018
A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells.
    eLife, 2018, 05-29, Volume: 7

    Topics: Animals; Biological Transport; Breast Neoplasms; Carbonic Anhydrase II; Female; Humans; Lactic Acid;

2018
The Effects of Thiamine on Breast Cancer Cells.
    Molecules (Basel, Switzerland), 2018, 06-16, Volume: 23, Issue:6

    Topics: Anaerobiosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Culture Media; Dose-Response Rela

2018
Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Collagenases; Drug Carriers; Female; Humans; Hydro

2018
Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.
    Molecular cancer, 2018, 07-16, Volume: 17, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Citric Acid; Down-Regulation; Female; Gene E

2018
Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma.
    Cancer medicine, 2018, Volume: 7, Issue:9

    Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytotoxicity, Immunolog

2018
Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 48, Issue:6

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tum

2018
Intratumor lactate levels reflect HER2 addiction status in HER2-positive breast cancer.
    Journal of cellular physiology, 2019, Volume: 234, Issue:2

    Topics: Animals; Antineoplastic Agents, Immunological; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor

2019
LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.
    PloS one, 2018, Volume: 13, Issue:9

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Gene Knockdown Techniques; Humans; Hypoxia-Indu

2018
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy.
    Journal of experimental & clinical cancer research : CR, 2018, Nov-29, Volume: 37, Issue:1

    Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Gefitinib; Humans; L

2018
Lactic Acid Accumulation in the Tumor Microenvironment Suppresses
    Cancer research, 2019, 01-15, Volume: 79, Issue:2

    Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Female; Fluorodeoxygl

2019
Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
    The AAPS journal, 2019, 01-07, Volume: 21, Issue:2

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coumaric Acids; Drug Screening Assays, Antitumor; Femal

2019
    CVIR endovascular, 2018, Volume: 1, Issue:1

    Topics: A549 Cells; Aged; Apoptosis; Brain; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Non-Smal

2018
Oxidized ATM-mediated glycolysis enhancement in breast cancer-associated fibroblasts contributes to tumor invasion through lactate as metabolic coupling.
    EBioMedicine, 2019, Volume: 41

    Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cancer-Associated Fibroblasts; Ca

2019
Multiplexed Single-Cell Measurements of FDG Uptake and Lactate Release Using Droplet Microfluidics.
    Technology in cancer research & treatment, 2019, 01-01, Volume: 18

    Topics: Biological Transport; Breast Neoplasms; Female; Fluorodeoxyglucose F18; Humans; Lactic Acid; Microfl

2019
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells.
    Nature cell biology, 2019, Volume: 21, Issue:4

    Topics: Aerobiosis; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Extracellular Vesicles;

2019
High Glucose-reduced Apoptosis in Human Breast Cancer Cells Is Mediated by Activation of NF-κB.
    Iranian journal of allergy, asthma, and immunology, 2019, Apr-01, Volume: 18, Issue:2

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Glucose; Humans; Lactic Acid; MCF-7 Cells;

2019
Cytochrome c1 as a favorable prognostic marker in estrogen receptor-positive breast carcinoma.
    Histology and histopathology, 2019, Volume: 34, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast; Breast Neoplasms; Carcinoma; Cell Line, T

2019
High extracellular lactate causes reductive carboxylation in breast tissue cell lines grown under normoxic conditions.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Cell Culture Techniques; Cell Line, Tumor; Citric Ac

2019
[Possibilities of cytological diagnostics of lactated breast adenoma. Clinical report.]
    Klinicheskaia laboratornaia diagnostika, 2019, Volume: 64, Issue:5

    Topics: Adenoma; Breast Neoplasms; Cytodiagnosis; Female; Humans; Lactic Acid; Pregnancy

2019
Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.
    European journal of pharmacology, 2019, Sep-15, Volume: 859

    Topics: Antineoplastic Agents; Apoptosis; Biological Transport; Breast Neoplasms; Catechin; Cell Line, Tumor

2019
Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer.
    Nanomedicine (London, England), 2013, Volume: 8, Issue:12

    Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxo

2013
Poly(D, L-lactide-co-glycolide)/montmorillonite nanoparticles for improved oral delivery of exemestane.
    Journal of microencapsulation, 2013, Volume: 30, Issue:5

    Topics: Androstadienes; Antineoplastic Agents; Bentonite; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor;

2013
Proteomic analysis and abrogated expression of O-GlcNAcylated proteins associated with primary breast cancer.
    Proteomics, 2013, Volume: 13, Issue:14

    Topics: Acetylglucosamine; Biomarkers, Tumor; Breast Neoplasms; Electrophoresis, Gel, Two-Dimensional; Femal

2013
Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior.
    Biomedical materials (Bristol, England), 2013, Volume: 8, Issue:3

    Topics: Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Movement; Cell

2013
Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism.
    Experimental cell research, 2013, Jul-15, Volume: 319, Issue:12

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Catechin; Cell Death; Cell Proliferation; Female

2013
Effects of chemically modified nanostructured PLGA on functioning of lung and breast cancer cells.
    International journal of nanomedicine, 2013, Volume: 8

    Topics: Alginates; Analysis of Variance; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Pro

2013
Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy.
    Acta biomaterialia, 2013, Volume: 9, Issue:11

    Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Cell Survival; Chromato

2013
Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Sep-15, Volume: 19, Issue:18

    Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation;

2013
Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity.
    Molecular pharmaceutics, 2013, Sep-03, Volume: 10, Issue:9

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Caco-2 Cells; Fema

2013
N-lauroyl chitosan surface-modified PLGA nanoparticles as carrier for adriamycin to overcome cancer drug resistance.
    Journal of microencapsulation, 2014, Volume: 31, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Chitosan; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm;

2014
Altered glucose metabolism in Harvey-ras transformed MCF10A cells.
    Molecular carcinogenesis, 2015, Volume: 54, Issue:2

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Membrane; Cell Transformation, Neoplastic; Citric Acid Cycl

2015
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Adult; Aged; Alanine; Animals; Breast Neoplasms; Cell Death; Cell Hypoxia; Cell Line, Tumor; Coumari

2013
Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures.
    NMR in biomedicine, 2013, Volume: 26, Issue:12

    Topics: Breast Neoplasms; Carbon Isotopes; Cell Survival; Female; Glucose; Glycolysis; Humans; Lactic Acid;

2013
Biodegradable self-assembled nanoparticles of poly (D,L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer.
    Biomaterials, 2014, Volume: 35, Issue:1

    Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Breast Neoplasms; Carbohydrate Sequence; Ce

2014
Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells.
    Journal of drug targeting, 2014, Volume: 22, Issue:1

    Topics: Antineoplastic Agents; Aptamers, Nucleotide; Breast Neoplasms; Cell Line; Cell Line, Tumor; Drug Del

2014
A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing.
    Nanomedicine : nanotechnology, biology, and medicine, 2014, Volume: 10, Issue:3

    Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Carriers; Female; Humans;

2014
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes.
    The Journal of biological chemistry, 2014, Jan-24, Volume: 289, Issue:4

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Glucose; Glycolysis; Humans; Lactic Acid; Male; NAD; Pro

2014
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jan-07, Volume: 111, Issue:1

    Topics: Active Transport, Cell Nucleus; Allosteric Site; Breast Neoplasms; Carrier Proteins; Cell Line, Tumo

2014
Is higher lactate an indicator of tumor metastatic risk? A pilot MRS study using hyperpolarized (13)C-pyruvate.
    Academic radiology, 2014, Volume: 21, Issue:2

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Humans; Lactic

2014
GPI/AMF inhibition blocks the development of the metastatic phenotype of mature multi-cellular tumor spheroids.
    Biochimica et biophysica acta, 2014, Volume: 1843, Issue:6

    Topics: 3T3 Cells; Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms; Carcinoma,

2014
Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways.
    International journal of cancer, 2014, Jun-15, Volume: 134, Issue:12

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Respiration; Down-Regulation; Epithelial Cells; Female; Gen

2014
Dual agent loaded PLGA nanoparticles enhanced antitumor activity in a multidrug-resistant breast tumor eenograft model.
    International journal of molecular sciences, 2014, Feb-18, Volume: 15, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Drug Carriers; Drug Resistance, Neoplas

2014
Development of intrinsically photoluminescent and photostable polylactones.
    Advanced materials (Deerfield Beach, Fla.), 2014, Jul-09, Volume: 26, Issue:26

    Topics: Animals; Biocompatible Materials; Breast Neoplasms; Diagnostic Imaging; Drug Delivery Systems; Femal

2014
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:6

    Topics: Animals; Breast Neoplasms; Colorectal Neoplasms; Coumarins; Female; HCT116 Cells; Humans; Lactic Aci

2014
Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.
    The Journal of biological chemistry, 2014, Jun-27, Volume: 289, Issue:26

    Topics: Amino Acid Motifs; Animals; Biological Transport; Breast Neoplasms; Down-Regulation; Female; Glucose

2014
Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles.
    Drug delivery, 2016, Volume: 23, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Female

2016
Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.
    Journal of cellular physiology, 2015, Volume: 230, Issue:1

    Topics: Apoptosis; Biological Transport; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferatio

2015
Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations.
    Drug delivery, 2016, Volume: 23, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter,

2016
Antiproliferative effect of ASC-J9 delivered by PLGA nanoparticles against estrogen-dependent breast cancer cells.
    Molecular pharmaceutics, 2014, Aug-04, Volume: 11, Issue:8

    Topics: 3T3-L1 Cells; Animals; Apoptosis; Biocompatible Materials; Breast Neoplasms; Cell Line, Tumor; Cell

2014
Poly(2-ethyl-2-oxazoline)-PLA-g-PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics.
    Journal of controlled release : official journal of the Controlled Release Society, 2014, Sep-10, Volume: 189

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; DNA, Circular; Doxorubicin

2014
Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer.
    Journal of controlled release : official journal of the Controlled Release Society, 2014, Oct-28, Volume: 192

    Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Carrie

2014
Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy.
    International journal of nanomedicine, 2014, Volume: 9

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Emulsions; Female; Humans;

2014
A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.
    Molecular systems biology, 2014, Aug-01, Volume: 10

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Computational Biology; Gene S

2014
Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer.
    International journal of biological macromolecules, 2015, Volume: 72

    Topics: Animals; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Lactic Acid; Nanoparticles; Rats;

2015
Multifunctional nanoparticle-EpCAM aptamer bioconjugates: a paradigm for targeted drug delivery and imaging in cancer therapy.
    Nanomedicine : nanotechnology, biology, and medicine, 2015, Volume: 11, Issue:2

    Topics: Antigens, Neoplasm; Apoptosis; Breast Neoplasms; Cell Adhesion Molecules; Drug Delivery Systems; Epi

2015
Promotion of initial anti-tumor effect via polydopamine modified doxorubicin-loaded electrospun fibrous membranes.
    International journal of clinical and experimental pathology, 2014, Volume: 7, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspa

2014
A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor receptor-2 positive breast tumor in vitro.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:1

    Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Combin

2015
A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Gene Expression Regulation

2016
Co-delivery of docetaxel and Poloxamer 235 by PLGA-TPGS nanoparticles for breast cancer treatment.
    Materials science & engineering. C, Materials for biological applications, 2015, Volume: 49

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Docetaxel; Drug Carriers; Drug Resistance

2015
High tolerated paclitaxel nano-formulation delivered by poly (lactic-co-glycolic acid)-g-dextran micelles to efficient cancer therapy.
    Nanomedicine : nanotechnology, biology, and medicine, 2015, Volume: 11, Issue:4

    Topics: Animals; Breast Neoplasms; Dextrans; Drug Resistance, Neoplasm; Female; Lactic Acid; MCF-7 Cells; Mi

2015
Development and characterization of folate anchored Saquinavir entrapped PLGA nanoparticles for anti-tumor activity.
    Drug development and industrial pharmacy, 2015, Volume: 41, Issue:11

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Compounding; Drug Del

2015
Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.
    NMR in biomedicine, 2015, Volume: 28, Issue:4

    Topics: Brain Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cell Hypoxia; Choline; Female; Humans; Lactic

2015
Enhanced anti-tumor immune responses and delay of tumor development in human epidermal growth factor receptor 2 mice immunized with an immunostimulatory peptide in poly(D,L-lactic-co-glycolic) acid nanoparticles.
    Breast cancer research : BCR, 2015, Mar-31, Volume: 17

    Topics: Animals; Antigen Presentation; Breast Neoplasms; Cancer Vaccines; Cell Transformation, Neoplastic; D

2015
Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells.
    Nanomedicine : nanotechnology, biology, and medicine, 2015, Volume: 11, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Caseins; Catechin; Cell Line, Tumor; Drug Resis

2015
Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells.
    Nanoscale, 2015, May-14, Volume: 7, Issue:18

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ce

2015
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice.
    The Journal of physiology, 2015, Jun-15, Volume: 593, Issue:12

    Topics: Animals; Basigin; Breast Neoplasms; Cell Line, Tumor; ERRalpha Estrogen-Related Receptor; Female; Hu

2015
Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.
    The Journal of pathology, 2015, Volume: 237, Issue:2

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cell Survival; Coculture Technique

2015
Preparation and Evaluation of Chrysin Encapsulated in PLGA- PEG Nanoparticles in the T47-D Breast Cancer Cell Line.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:9

    Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclin D1; Drug Carr

2015
Nutrient depletion and metabolic profiles in breast carcinoma cell lines measured with a label-free platform.
    Physiological measurement, 2015, Volume: 36, Issue:7

    Topics: Actins; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Survival; Cytocha

2015
Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment.
    Drug delivery, 2016, Volume: 23, Issue:7

    Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiox

2016
Nanomicellar Formulation of Clotrimazole Improves Its Antitumor Action toward Human Breast Cancer Cells.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line,

2015
Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:6

    Topics: Breast Neoplasms; Cytotoxins; Drug Carriers; Female; Flavonoids; Humans; Lactic Acid; MCF-7 Cells; N

2016
A study of the relationship of metabolic MR parameters to estrogen dependence in breast cancer xenografts.
    NMR in biomedicine, 2015, Volume: 28, Issue:9

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Humans; Lactic Acid; Magn

2015
Novel nanosystem to enhance the antitumor activity of lapatinib in breast cancer treatment: Therapeutic efficacy evaluation.
    Cancer science, 2015, Volume: 106, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Female

2015
A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Hypoxia; Cell Proliferation; Dose-Response

2015
Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
    Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:10

    Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Ag

2015
Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:9

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Sur

2015
PLGA nanoparticle formulation of RK-33: an RNA helicase inhibitor against DDX3.
    Cancer chemotherapy and pharmacology, 2015, Volume: 76, Issue:4

    Topics: Animals; Antineoplastic Agents; Azepines; Breast Neoplasms; Carcinoma; Cell Survival; Delayed-Action

2015
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
    Scientific reports, 2015, Sep-04, Volume: 5

    Topics: Antigens, Neoplasm; Breast Neoplasms; Carbonic Anhydrase IX; Carbonic Anhydrases; Catalysis; Cell Hy

2015
Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways.
    Oncotarget, 2015, Sep-22, Volume: 6, Issue:28

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Energy Metabolism; Epithel

2015
Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid).
    Acta biomaterialia, 2016, Volume: 29

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Chitosan; Female; Humans; Lactic Acid; Mice; Mice, Inbr

2016
Multifunctional PLGA Nanobubbles as Theranostic Agents: Combining Doxorubicin and P-gp siRNA Co-Delivery Into Human Breast Cancer Cells and Ultrasound Cellular Imaging.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:12

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Co

2015
Preparation of Engineered Salmonella Typhimurium-Driven Hyaluronic-Acid-Based Microbeads with Both Chemotactic and Biological Targeting Towards Breast Cancer Cells for Enhanced Anticancer Therapy.
    Advanced healthcare materials, 2016, Jan-21, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chemotaxis; Docetaxe

2016
The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.
    Lab on a chip, 2016, Jan-07, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Biomechanical Phenomena; Breast Neoplasms; Cell Line, Tumor; Cell Proliferati

2016
Enhanced delivery of Paclitaxel using electrostatically-conjugated Herceptin-bearing PEI/PLGA nanoparticles against HER-positive breast cancer cells.
    International journal of pharmaceutics, 2016, Jan-30, Volume: 497, Issue:1-2

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Drug Screening As

2016
Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin.
    Colloids and surfaces. B, Biointerfaces, 2016, Feb-01, Volume: 138

    Topics: Animals; Antibiotics, Antineoplastic; Biotinylation; Breast Neoplasms; Carbocyanines; Cell Survival;

2016
Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:6

    Topics: 5'-Nucleotidase; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chitosan; Down-Regulati

2016
Modulation of the uptake of critical nutrients by breast cancer cells by lactate: Impact on cell survival, proliferation and migration.
    Experimental cell research, 2016, Feb-15, Volume: 341, Issue:2

    Topics: Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Su

2016
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth.
    Scientific reports, 2016, Feb-26, Volume: 6

    Topics: Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Drug Carriers; Humans; Lactic Ac

2016
Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery.
    Biomaterials, 2016, Volume: 88

    Topics: Animals; Breast; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Delayed-Action Preparation

2016
Luteinizing hormone-releasing hormone peptide tethered nanoparticulate system for enhanced antitumoral efficacy of paclitaxel.
    Nanomedicine (London, England), 2016, Volume: 11, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast; Breast Neoplasms; Drug Carriers; Female; Gonadot

2016
Modulation of Mammary Stromal Cell Lactate Dynamics by Ambient Glucose and Epithelial Factors.
    Journal of cellular physiology, 2017, Volume: 232, Issue:1

    Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Coculture Techniques; Epithelial Cells; G

2017
Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations.
    Journal of nanobiotechnology, 2016, Apr-21, Volume: 14

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Disulfiram; Drug Carriers; Female; Folate Recepto

2016
Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells.
    Cell biochemistry and biophysics, 2016, Volume: 74, Issue:3

    Topics: Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Caspase 3; Cell Line, Tu

2016
PFKFB3 potentially contributes to paclitaxel resistance in breast cancer cells through TLR4 activation by stimulating lactate production.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, May-30, Volume: 62, Issue:6

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Silencing

2016
Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer.
    Journal of biomedical nanotechnology, 2016, Volume: 12, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tum

2016
Voxel-by-voxel correlations of perfusion, substrate, and metabolite signals in dynamic hyperpolarized (13) C imaging.
    NMR in biomedicine, 2016, Volume: 29, Issue:8

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line,

2016
Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles.
    Biomacromolecules, 2016, 07-11, Volume: 17, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Biocompatible Materials; Breast Neoplasms; Cell Survival

2016
Molecular mechanism of (18)F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism.
    Nuclear medicine and biology, 2016, Volume: 43, Issue:10

    Topics: Biological Transport; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relations

2016
Non-specific binding and steric hindrance thresholds for penetration of particulate drug carriers within tumor tissue.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 09-28, Volume: 238

    Topics: Albumin-Bound Paclitaxel; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor

2016
3B, a novel photosensitizer, inhibits glycolysis and inflammation via miR-155-5p and breaks the JAK/STAT3/SOCS1 feedback loop in human breast cancer cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 82

    Topics: Adenosine Triphosphate; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Feedback, Physiological;

2016
Transformation by different oncogenes relies on specific metabolic adaptations.
    Cell cycle (Georgetown, Tex.), 2016, Volume: 15, Issue:19

    Topics: Adaptation, Physiological; Animals; Breast Neoplasms; Cell Respiration; Cell Transformation, Neoplas

2016
Adrenal Hormone and Metabolic Biomarker Responses to 30 min of Intermittent Cycling Exercise in Breast Cancer Survivors.
    International journal of sports medicine, 2016, Volume: 37, Issue:12

    Topics: Adult; Aged; Bicycling; Biomarkers; Blood Glucose; Breast Neoplasms; Case-Control Studies; Epinephri

2016
A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Animals; Antibodies, Antinuclear; Antibodies, Catalytic; Breast Neoplasms; Cell Line, Tumor; DNA; Do

2016
Measuring relative utilization of aerobic glycolysis in breast cancer cells by positional isotopic discrimination.
    FEBS letters, 2016, Volume: 590, Issue:18

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Glycolysis; Humans; Lactic Acid; Mice; Mice, In

2016
Chitosan-modified PLGA polymeric nanocarriers with better delivery potential for tamoxifen.
    International journal of biological macromolecules, 2016, Volume: 93, Issue:Pt A

    Topics: Administration, Topical; Animals; Breast Neoplasms; Chitosan; Drug Carriers; Female; Humans; Lactic

2016
Exercise regulates breast cancer cell viability: systemic training adaptations versus acute exercise responses.
    Breast cancer research and treatment, 2016, Volume: 159, Issue:3

    Topics: Adult; Breast Neoplasms; Cancer Survivors; Cell Line, Tumor; Cholesterol; Cytokines; Epinephrine; Ex

2016
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
    Biophysical journal, 2016, Sep-06, Volume: 111, Issue:5

    Topics: Adenosine Triphosphate; Algorithms; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferatio

2016
Tumor stroma-containing 3D spheroid arrays: A tool to study nanoparticle penetration.
    Journal of controlled release : official journal of the Controlled Release Society, 2016, 12-28, Volume: 244, Issue:Pt B

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Coculture Techniques; Female; Humans; Lactic Acid; Mice

2016
G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.
    Oncotarget, 2016, Oct-25, Volume: 7, Issue:43

    Topics: Amphiregulin; Animals; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ce

2016
Enhanced stimulation of anti-breast cancer T cells responses by dendritic cells loaded with poly lactic-co-glycolic acid (PLGA) nanoparticle encapsulated tumor antigens.
    Journal of experimental & clinical cancer research : CR, 2016, 10-26, Volume: 35, Issue:1

    Topics: Antigens, Neoplasm; Breast Neoplasms; Cancer Vaccines; Cells, Cultured; Dendritic Cells; Female; Hum

2016
TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.
    The Journal of biological chemistry, 2016, Dec-16, Volume: 291, Issue:51

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Coculture Techniques; Female; Fibroblast

2016
Formulation and evaluation of targeted nanoparticles for breast cancer theranostic system.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Jan-15, Volume: 97

    Topics: Breast Neoplasms; Cell Survival; Drug Compounding; Drug Delivery Systems; Drug Evaluation, Preclinic

2017
Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.
    Biochimica et biophysica acta. Molecular basis of disease, 2017, Volume: 1863, Issue:2

    Topics: Acetyl Coenzyme A; Aspartic Acid; Biosynthetic Pathways; Breast Neoplasms; Cell Line, Tumor; Cell Pr

2017
Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy.
    Nanomedicine : nanotechnology, biology, and medicine, 2017, Volume: 13, Issue:3

    Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Drug Carriers; Drug Delivery Systems; Fema

2017
Synthesis, Characterization, and Biological Evaluation of Anti-HER2 Indocyanine Green-Encapsulated PEG-Coated PLGA Nanoparticles for Targeted Phototherapy of Breast Cancer Cells.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Breast Neoplasms; Drug Delivery Systems; Humans; Indocyanine Green; Lactic Acid; MCF-7 Cells; Nanopa

2016
CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 01-28, Volume: 246

    Topics: 5'-Nucleotidase; Animals; Breast; Breast Neoplasms; Cancer Vaccines; Cell Line, Tumor; Chitosan; Den

2017
Disease Subtype-Independent Biomarkers of Breast Cancer Chemoprevention by the Ayurvedic Medicine Phytochemical Withaferin A.
    Journal of the National Cancer Institute, 2017, Volume: 109, Issue:6

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetyl Coenzyme A; Aldehyde Dehydrogenase 1 Family; Animals; Apoptosis;

2017
Synthesis, characterization, and in vitro evaluation of targeted gold nanoshelled poly(d,l-lactide-co-glycolide) nanoparticles carrying anti p53 antibody as a theranostic agent for ultrasound contrast imaging and photothermal therapy.
    Journal of biomaterials science. Polymer edition, 2017, Volume: 28, Issue:4

    Topics: Breast Neoplasms; Chemistry Techniques, Synthetic; Contrast Media; Gold; Humans; Immunoconjugates; L

2017
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 01-17, Volume: 114, Issue:3

    Topics: Animals; Breast Neoplasms; Cell Adhesion; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Fema

2017
Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Antineoplastic Agents; Breast Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Carcinoma, Squam

2016
l-arginine alters the effect of 5-fluorouracil on breast cancer cells in favor of apoptosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: Apoptosis; Arginine; Breast Neoplasms; Cell Movement; Cell Survival; Chemokine CXCL12; Female; Fluor

2017
Tumor stroma interaction is mediated by monocarboxylate metabolism.
    Experimental cell research, 2017, 03-01, Volume: 352, Issue:1

    Topics: Autocrine Communication; Breast Neoplasms; Carbon Radioisotopes; Cell Communication; Cells, Cultured

2017
Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles.
    Drug delivery, 2017, Volume: 24, Issue:1

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis;

2017
The Effect of Chrysin Loaded PLGA-PEG on Metalloproteinase Gene Expression in Mouse 4T1 Tumor Model.
    Drug research, 2017, Volume: 67, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Carrier

2017
CXCR4-targeted Nanoparticles Reduce Cell Viability, Induce Apoptosis and Inhibit SDF-1α Induced BT-549-Luc Cell Migration In Vitro.
    Current drug delivery, 2017, Volume: 14, Issue:8

    Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Cell Su

2017
Co-delivery of Doxorubicin Encapsulated PLGA Nanoparticles and Bcl-xL shRNA Using Alkyl-Modified PEI into Breast Cancer Cells.
    Applied biochemistry and biotechnology, 2017, Volume: 183, Issue:1

    Topics: bcl-X Protein; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Imines; Lactic Acid; MCF-7 C

2017
Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug

2017
Laser irradiated fluorescent perfluorocarbon microparticles in 2-D and 3-D breast cancer cell models.
    Scientific reports, 2017, 03-06, Volume: 7

    Topics: Acoustics; Breast Neoplasms; Carbocyanines; Contrast Media; Female; Fluorescent Dyes; Fluorocarbons;

2017
Regulation of the Warburg effect in early-passage breast cancer cells.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:8

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Glucose; Glucose Transp

2008
Rhodamine-loaded poly(lactic-co-glycolic acid) nanoparticles for investigation of in vitro interactions with breast cancer cells.
    Journal of materials science. Materials in medicine, 2009, Volume: 20, Issue:1

    Topics: Biocompatible Materials; Biological Transport, Active; Breast Neoplasms; Cell Line, Tumor; Drug Deli

2009
The malignant phenotype of breast cancer cells is reduced by COX-2 silencing.
    Neoplasia (New York, N.Y.), 2008, Volume: 10, Issue:11

    Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Cycloo

2008
The genomic analysis of lactic acidosis and acidosis response in human cancers.
    PLoS genetics, 2008, Volume: 4, Issue:12

    Topics: Acidosis; Breast Neoplasms; Cells, Cultured; Energy Metabolism; Female; Gene Expression Profiling; G

2008
Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique.
    Drug development and industrial pharmacy, 2009, Volume: 35, Issue:8

    Topics: Breast Neoplasms; Calorimetry, Differential Scanning; Cell Line, Tumor; Chemistry, Pharmaceutical; D

2009
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
    Cancer investigation, 2009, Volume: 27, Issue:6

    Topics: Antigens, Neoplasm; Breast Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic

2009
Cytotoxicity of paclitaxel incorporated in PLGA nanoparticles on hypoxic human tumor cells.
    Pharmaceutical research, 2009, Volume: 26, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma; Cell Hypoxia; Cell Survival

2009
Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents.
    Ultrasonics, 2009, Volume: 49, Issue:8

    Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Contrast Media; Delayed-

2009
Inactivation of harmful tumour-associated proteolysis by nanoparticulate system.
    International journal of pharmaceutics, 2009, Nov-03, Volume: 381, Issue:2

    Topics: Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Caco-2 Cells; Cathepsin B; Cell Adhe

2009
Mitochondrial DNA depletion promotes impaired oxidative status and adaptive resistance to apoptosis in T47D breast cancer cells.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2009, Volume: 18, Issue:6

    Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents,

2009
Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy.
    Biomaterials, 2009, Volume: 30, Issue:29

    Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; ErbB

2009
A dual-emissive-materials design concept enables tumour hypoxia imaging.
    Nature materials, 2009, Volume: 8, Issue:9

    Topics: Animals; Breast Neoplasms; Disease Models, Animal; Hypoxia; Lactic Acid; Mice; Nanoparticles; Neopla

2009
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.
    Oncogene, 2009, Oct-22, Volume: 28, Issue:42

    Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxyglucose;

2009
Sustained delivery and efficacy of polymeric nanoparticles containing osteopontin and bone sialoprotein antisenses in rats with breast cancer bone metastasis.
    International journal of cancer, 2010, Apr-01, Volume: 126, Issue:7

    Topics: Animals; Bone Neoplasms; Breast Neoplasms; Drug Delivery Systems; Female; Humans; Integrin-Binding S

2010
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF-7.
    Journal of applied toxicology : JAT, 2010, Volume: 30, Issue:3

    Topics: Acetaldehyde; Adenosine Triphosphate; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brea

2010
Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Oct-27, Volume: 106, Issue:43

    Topics: Biological Transport; Breast Neoplasms; Carbon Isotopes; Cell Hypoxia; Cell Survival; Humans; Kineti

2009
Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells.
    International journal of pharmaceutics, 2010, May-10, Volume: 390, Issue:2

    Topics: Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry,

2010
Multifunctional nanoparticles of biodegradable copolymer blend for cancer diagnosis and treatment.
    Nanomedicine (London, England), 2010, Volume: 5, Issue:3

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Membrane Permeability; Cell

2010
Hypoxia induces differential translation of enolase/MBP-1.
    BMC cancer, 2010, Apr-22, Volume: 10

    Topics: Breast Neoplasms; Cell Cycle; Cell Growth Processes; Cell Hypoxia; Cell Line, Tumor; DNA-Binding Pro

2010
Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention.
    Cancer research, 2010, Jun-01, Volume: 70, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor

2010
Nanoparticles of lipid monolayer shell and biodegradable polymer core for controlled release of paclitaxel: effects of surfactants on particles size, characteristics and in vitro performance.
    International journal of pharmaceutics, 2010, Aug-16, Volume: 395, Issue:1-2

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Pha

2010
Preparation and in-vitro/in-vivo evaluation of surface-modified poly (lactide-co-glycolide) fluorescent nanoparticles.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:4

    Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Chitosan; Coumarins; Drug Carrier

2010
Development of novel self-assembled DS-PLGA hybrid nanoparticles for improving oral bioavailability of vincristine sulfate by P-gp inhibition.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Dec-01, Volume: 148, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter,

2010
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
    Cell cycle (Georgetown, Tex.), 2010, Aug-15, Volume: 9, Issue:16

    Topics: Autophagy; Biological Evolution; Breast Neoplasms; Caveolin 1; Cell Line; Coculture Techniques; DNA

2010
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Sep-01, Volume: 9, Issue:17

    Topics: 3-Hydroxybutyric Acid; Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female

2010
Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation.
    International journal of nanomedicine, 2010, Sep-07, Volume: 5

    Topics: Breast Neoplasms; Chemical Phenomena; Drug Carriers; Drug Delivery Systems; Drug Stability; Estrogen

2010
The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen.
    Biomaterials, 2011, Volume: 32, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Lactic Aci

2011
Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation.
    Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:12

    Topics: Animals; Breast Neoplasms; Cell Growth Processes; Cell Line; Cell Line, Tumor; Gene Knock-In Techniq

2010
Exercise in patients with breast cancer and healthy controls: energy substrate oxidation and blood lactate responses.
    Integrative cancer therapies, 2011, Volume: 10, Issue:1

    Topics: Blood Glucose; Breast Neoplasms; Carbohydrate Metabolism; Case-Control Studies; Energy Metabolism; E

2011
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
    Cancer research, 2011, Apr-01, Volume: 71, Issue:7

    Topics: Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Humans; Hypoxia-Ind

2011
Chondroitin sulphate decorated nanoparticulate carriers of 5-fluorouracil: development and in vitro characterization.
    Journal of biomedical nanotechnology, 2010, Volume: 6, Issue:4

    Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Chondroitin Sulfates; Drug Carr

2010
Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.
    Biomaterials, 2011, Volume: 32, Issue:15

    Topics: Adenocarcinoma; Breast Neoplasms; Cell Line, Tumor; DNA; Female; Gene Transfer Techniques; Genetic T

2011
Reversal of doxorubicin-resistance by multifunctional nanoparticles in MCF-7/ADR cells.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Jun-30, Volume: 152, Issue:3

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Nu

2011
13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns.
    NMR in biomedicine, 2011, Volume: 24, Issue:10

    Topics: Alanine; Animals; Breast Neoplasms; Carbon Isotopes; Female; Gene Expression Regulation, Neoplastic;

2011
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:3

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Transport; Breast Neoplasms; C

2011
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.
    Cell cycle (Georgetown, Tex.), 2011, Apr-15, Volume: 10, Issue:8

    Topics: Acetyl Coenzyme A; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Citric Acid Cycle; Female;

2011
Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues.
    Molecular genetics and metabolism, 2011, Volume: 103, Issue:4

    Topics: Actins; Anticarcinogenic Agents; Breast Neoplasms; Clotrimazole; Female; Glucose; Glycolysis; Humans

2011
Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model.
    Molecular pharmaceutics, 2011, Aug-01, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Creatine Kinase; D

2011
Krüppel-like factor 4 (KLF4) activates the transcription of the gene for the platelet isoform of phosphofructokinase (PFKP) in breast cancer.
    The Journal of biological chemistry, 2011, Jul-08, Volume: 286, Issue:27

    Topics: Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Enzymologic; Gene Expression

2011
Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.
    Cancer biology & therapy, 2011, Nov-15, Volume: 12, Issue:10

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Breast Neoplasms; Cell Line,

2011
Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
    Cell cycle (Georgetown, Tex.), 2011, Dec-01, Volume: 10, Issue:23

    Topics: Animals; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cellular Senescence; Coculture Techniques;

2011
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment.
    Experimental cell research, 2012, Feb-15, Volume: 318, Issue:4

    Topics: Breast Neoplasms; Carcinoma; Cell Communication; Cell Line, Tumor; Female; Fibroblasts; Glycolysis;

2012
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
    Cancer biology & therapy, 2011, Dec-15, Volume: 12, Issue:12

    Topics: Animals; Autophagy; Breast Neoplasms; Caveolin 1; Cell Communication; Cell Growth Processes; Cell Li

2011
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.
    NMR in biomedicine, 2012, Volume: 25, Issue:2

    Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Choline; Choline Kinase; Choline-Phosphate Cytidylyl

2012
Bypassing multidrug resistance in human breast cancer cells with lipid/polymer particle assemblies.
    International journal of nanomedicine, 2012, Volume: 7

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfami

2012
Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.
    Cell cycle (Georgetown, Tex.), 2012, Mar-15, Volume: 11, Issue:6

    Topics: Adult; Aged; Biomarkers; Breast Neoplasms; Caveolin 1; Cohort Studies; Epithelium; Female; Fibroblas

2012
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.
    Journal of bioenergetics and biomembranes, 2012, Volume: 44, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Butyrates; Cell Line, Tumor; Cell Su

2012
Folate receptor targeted 17-allylamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric nanoparticles for breast cancer.
    Colloids and surfaces. B, Biointerfaces, 2012, Jun-01, Volume: 94

    Topics: Antineoplastic Agents; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carrie

2012
Lactate and glycine-potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers.
    NMR in biomedicine, 2012, Volume: 25, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cohort Studies; Discriminant An

2012
RGD-conjugated PLA-PLL nanoparticles targeting to Bacp-37 breast cancer xenografts in vivo.
    Journal of nanoscience and nanotechnology, 2011, Volume: 11, Issue:12

    Topics: Biocompatible Materials; Breast Neoplasms; Female; Flow Cytometry; Humans; Lactic Acid; Lysine; Micr

2011
Poly-lactic-glycolic-acid surface nanotopographies selectively decrease breast adenocarcinoma cell functions.
    Nanotechnology, 2012, Apr-20, Volume: 23, Issue:15

    Topics: Adenocarcinoma; Apoptosis; Breast; Breast Neoplasms; Cell Adhesion; Cell Count; Cell Line, Tumor; Ce

2012
Lactate-induced IL-8 pathway in endothelial cells--letter.
    Cancer research, 2012, Apr-01, Volume: 72, Issue:7

    Topics: Breast Neoplasms; Colorectal Neoplasms; Humans; Interleukin-8; Lactic Acid; Monocarboxylic Acid Tran

2012
Superparamagnetic PLGA-iron oxide microcapsules for dual-modality US/MR imaging and high intensity focused US breast cancer ablation.
    Biomaterials, 2012, Volume: 33, Issue:24

    Topics: Animals; Breast; Breast Neoplasms; Capsules; Contrast Media; Female; Ferric Compounds; High-Intensit

2012
Regulation of glycolysis and the Warburg effect by estrogen-related receptors.
    Oncogene, 2013, Apr-18, Volume: 32, Issue:16

    Topics: Adenosine Triphosphate; Aerobiosis; Animals; Breast Neoplasms; Cell Growth Processes; Cell Line, Tum

2013
Alendronate coated poly-lactic-co-glycolic acid (PLGA) nanoparticles for active targeting of metastatic breast cancer.
    Biomaterials, 2012, Volume: 33, Issue:29

    Topics: Alendronate; Animals; Antineoplastic Agents; Bone and Bones; Bone Neoplasms; Boronic Acids; Bortezom

2012
Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.
    Cell cycle (Georgetown, Tex.), 2012, Aug-15, Volume: 11, Issue:16

    Topics: Animals; Autocrine Communication; Autophagy; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Cell Tr

2012
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
    Cell cycle (Georgetown, Tex.), 2012, Sep-01, Volume: 11, Issue:17

    Topics: Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Cell Line, Tumor; Electron Transport

2012
CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.
    Cell cycle (Georgetown, Tex.), 2012, Oct-01, Volume: 11, Issue:19

    Topics: Animals; Autophagy; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cellular Senescence; Cyclin-De

2012
Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.
    NMR in biomedicine, 2013, Volume: 26, Issue:3

    Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Female; Humans; Lactic Acid; Male; MCF-7 Cells; Mito

2013
Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:3

    Topics: Adult; Aged; Anaerobic Threshold; Breast Neoplasms; Cardiovascular Deconditioning; Exercise Test; Fa

2013
Estrogen and retinoic acid antagonistically regulate several microRNA genes to control aerobic glycolysis in breast cancer cells.
    Molecular bioSystems, 2012, Oct-30, Volume: 8, Issue:12

    Topics: Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogens; Female; Gene Expression Regulation, Neopla

2012
Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells.
    Cell cycle (Georgetown, Tex.), 2012, Nov-01, Volume: 11, Issue:21

    Topics: Acetyl-CoA C-Acetyltransferase; Breast Neoplasms; Caveolin 1; Cell Line; Chaperonin 60; Coculture Te

2012
Herceptin-decorated salinomycin-loaded nanoparticles for breast tumor targeting.
    Journal of biomedical materials research. Part A, 2013, Volume: 101, Issue:5

    Topics: Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Delaye

2013
Transforming growth factor-β: guardian of catabolic metabolism in carcinoma-associated fibroblasts.
    Cell cycle (Georgetown, Tex.), 2012, Dec-01, Volume: 11, Issue:23

    Topics: Animals; Breast Neoplasms; Female; Fibroblasts; Humans; Lactic Acid; Paracrine Communication; Transf

2012
Intracellular drug release from curcumin-loaded PLGA nanoparticles induces G2/M block in breast cancer cells.
    Biomacromolecules, 2013, Mar-11, Volume: 14, Issue:3

    Topics: Apoptosis; Biocompatible Materials; Biological Availability; Breast Neoplasms; Cell Cycle Checkpoint

2013
Glycolysis as a metabolic marker in orthotopic breast cancer, monitored by in vivo (13)C MRS.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:4

    Topics: Animals; Biomarkers; Breast Neoplasms; Carbon Isotopes; Disease Models, Animal; Female; Glucose; Gly

2002
Polymeric contrast agent with targeting potential.
    Ultrasonics, 2004, Volume: 42, Issue:1-9

    Topics: Analysis of Variance; Breast Neoplasms; Contrast Media; Diagnosis, Differential; Humans; Lactic Acid

2004
Formulation and characterization of Paclitaxel, 5-FU and Paclitaxel + 5-FU microspheres.
    International journal of pharmaceutics, 2004, May-19, Volume: 276, Issue:1-2

    Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Chemistry, Pharmaceutic

2004
Metabolism of the microregions of human breast cancer.
    Cancer letters, 2004, Dec-28, Volume: 216, Issue:2

    Topics: Adolescent; Adult; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fructose-Bisphosphate

2004
Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions.
    Biomaterials, 2005, Volume: 26, Issue:24

    Topics: Acrylamides; Acrylic Resins; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Coa

2005
Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes.
    Molecular genetics and metabolism, 2005, Volume: 84, Issue:4

    Topics: Actins; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Cell Survival; Clotrimazole;

2005
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
    Cancer research, 2006, Jan-15, Volume: 66, Issue:2

    Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme I

2006
Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens.
    Breast cancer research and treatment, 2006, Volume: 96, Issue:3

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bioreactors; Breast Neoplasms; Cell Line, Tumor;

2006
Proliferation, viability, and metabolism of human tumor and normal cells cultured in microcapsule.
    Applied biochemistry and biotechnology, 2006, Volume: 134, Issue:1

    Topics: Alginates; Biocompatible Materials; Biotechnology; Breast Neoplasms; Cell Culture Techniques; Cell L

2006
Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis.
    Metabolic engineering, 2006, Volume: 8, Issue:6

    Topics: Algorithms; Amino Acids; Biosynthetic Pathways; Breast Neoplasms; Carbon Isotopes; Cell Line, Tumor;

2006
Folate-decorated poly(lactide-co-glycolide)-vitamin E TPGS nanoparticles for targeted drug delivery.
    Biomaterials, 2007, Volume: 28, Issue:10

    Topics: Animals; Breast Neoplasms; Capsules; Cell Line, Tumor; Cell Survival; Coated Materials, Biocompatibl

2007
TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors.
    Journal of controlled release : official journal of the Controlled Release Society, 2007, Apr-02, Volume: 118, Issue:2

    Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Nucl

2007
The effect of paclitaxel-loaded nanoparticles with radiation on hypoxic MCF-7 cells.
    Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Combined Modality Therapy; De

2007
Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody.
    Journal of controlled release : official journal of the Controlled Release Society, 2007, Jul-16, Volume: 120, Issue:1-2

    Topics: Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Breast Neoplasms; Caco-2 Cells; Ce

2007
Multifunctional poly(D,L-lactide-co-glycolide)/montmorillonite (PLGA/MMT) nanoparticles decorated by Trastuzumab for targeted chemotherapy of breast cancer.
    Biomaterials, 2008, Volume: 29, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bentonite; Breast Neoplasms; Cell Line, T

2008
Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, Jun-24, Volume: 128, Issue:3

    Topics: ADP Ribose Transferases; Animals; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Agent

2008
The effect of ifosfamide on tumor oxygenation at different temperatures.
    Advances in experimental medicine and biology, 1994, Volume: 345

    Topics: Animals; Breast Neoplasms; Female; Humans; Hydrogen-Ion Concentration; Ifosfamide; Lactates; Lactic

1994
Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 17 beta-estradiol in MCF-7 human breast cancer cells.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 44, Issue:3

    Topics: Base Sequence; Breast Neoplasms; Cathepsin D; Cell Division; Cytochrome P-450 CYP1A1; Cytochrome P-4

1993
Breast cancer cells have a high capacity to acidify extracellular milieu by a dual mechanism.
    Clinical & experimental metastasis, 1997, Volume: 15, Issue:4

    Topics: Acids; Amiloride; Anti-Bacterial Agents; Breast; Breast Neoplasms; Cells, Cultured; Extracellular Sp

1997
Metabolism in myocutaneous flaps studied by in situ microdialysis.
    Scandinavian journal of plastic and reconstructive surgery and hand surgery, 1998, Volume: 32, Issue:1

    Topics: Adult; Aged; Blood Glucose; Breast Neoplasms; Combined Modality Therapy; Energy Metabolism; Female;

1998
Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 1998, Volume: 135, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Diag

1998
Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivation.
    The Journal of biological chemistry, 2000, Feb-25, Volume: 275, Issue:8

    Topics: Adenosine Triphosphate; Amiloride; Ammonium Chloride; Androstadienes; Blood; Blotting, Western; Brea

2000
Real-time measurements of cellular oxygen consumption, pH, and energy metabolism using nuclear magnetic resonance spectroscopy.
    Magnetic resonance in medicine, 2001, Volume: 45, Issue:5

    Topics: Adenosine Triphosphate; Animals; Breast Neoplasms; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Energy

2001
Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:10

    Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Neoplasm; Antibody Specific

2001
Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited.
    Experimental cell research, 2002, May-15, Volume: 276, Issue:1

    Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line; Culture Media; Dose-Response Relationship, D

2002
Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells.
    The Biochemical journal, 2002, May-15, Volume: 364, Issue:Pt 1

    Topics: Adenosine Triphosphate; Air; Breast Neoplasms; Cell Division; Cells, Cultured; Fatty Acids; Glucose;

2002
Treatment of malignant pleural effusions with doxorubicin hydrochloride-containing poly(L-lactic acid) microspheres.
    Chest, 1991, Volume: 99, Issue:4

    Topics: Aged; Breast Neoplasms; Chest Tubes; Delayed-Action Preparations; Doxorubicin; Drainage; Drug Carrie

1991
Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy.
    Cancer research, 1989, Feb-01, Volume: 49, Issue:3

    Topics: Breast Neoplasms; Cell Line; Estradiol; Glucose; Glutamates; Glutamic Acid; Humans; Lactates; Lactic

1989
Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats.
    Cancer research, 1988, Dec-15, Volume: 48, Issue:24 Pt 1

    Topics: Animals; Breast Neoplasms; Glucose; Humans; Hydrogen-Ion Concentration; Ketone Bodies; Lactates; Lac

1988
A versatile multinuclear probe designed for in vivo NMR spectroscopy: applications to subcutaneous human tumors in mice.
    Magnetic resonance in medicine, 1988, Volume: 6, Issue:1

    Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Glucose; Humans; In Vitro Techniques; Infant, Newborn;

1988
Glucose, lactate, and ketone body utilization by human mammary carcinomas in vivo.
    Advances in experimental medicine and biology, 1985, Volume: 191

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Breast Neoplasms; Carcinoma; Female; Glucose; Humans;

1985