lactic acid has been researched along with Brain Swelling in 106 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 7.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 7.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 7.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 7.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 7.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Treatment with bumetanide may help diminish the adverse effects of initial treatment with insulin/saline." | 5.36 | Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. ( Anderson, SE; Glaser, N; O'Donnell, ME; Tancredi, DJ; Yuen, N, 2010) |
| "Increased brain lactate, and not glutamine, is a primary player in the pathogenesis of brain edema in CLD." | 3.80 | Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. ( Bosoi, CR; Huynh, J; Marin, H; Parent-Robitaille, C; Rose, CF; Tremblay, M; Zwingmann, C, 2014) |
| "The pathogenesis of brain edema in an experimental model of ALF involves a cytotoxic mechanism: the metabolism of ammonia in astrocytes induces an increase of glutamine and lactate that appears to mediate cellular swelling." | 3.76 | Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. ( Alonso, J; Chavarria, L; Cordoba, J; Lope-Piedrafita, S; Oria, M; Romero-Gimenez, J, 2010) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 3.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 3.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 3.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 3.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 3.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "SL is an effective therapy for treating brain edema after TBI." | 1.62 | The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach. ( Duhaut, DE; Gandin, C; Heurteaux, C; Ichai, C; Quintard, H, 2021) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation." | 1.37 | Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. ( Agusti, A; Boix, J; Cauli, O; Cerdán, S; Felipo, V; López-Larrubia, P; Nieto-Charques, L; Rodrigo, R, 2011) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Patients with global cerebral edema on admission (n=24 [62%]) had a higher incidence of metabolic crisis in the first 12 hours of monitoring (n=15 [15% versus 2%], P<0." | 1.37 | Global cerebral edema and brain metabolism after subarachnoid hemorrhage. ( Badjatia, N; Choi, HA; Claassen, J; Connolly, ES; Fernandez, L; Helbok, R; Ko, SB; Kurtz, P; Lee, K; Mayer, SA; Schmidt, JM, 2011) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Treatment with bumetanide may help diminish the adverse effects of initial treatment with insulin/saline." | 1.36 | Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. ( Anderson, SE; Glaser, N; O'Donnell, ME; Tancredi, DJ; Yuen, N, 2010) |
| "Previous studies of spontaneous subarachnoid hemorrhage (SAH) have shown that global cerebral edema on the first computed tomography scan is associated with a more severe initial injury and is an independent predictor of poor outcome." | 1.36 | Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema. ( Enblad, P; Hallberg, L; Hillered, L; Karlsson, T; Ronne Engström, E; Zetterling, M, 2010) |
| "In 17 patients (aged 18-60 years) with acute liver failure and severe hyperammonemia (182 ± 36 μM (mean ± SD)), cerebral microdialysis was performed, and ICP and CPP were monitored." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| " Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "Perimural edema and hydrocephalus were observed only in patients treated with HydroCoils, but have been reported in patients treated with other modified platinum coils." | 1.35 | Wall enhancement, edema, and hydrocephalus after endovascular coil occlusion of intradural cerebral aneurysms. ( Fanning, NF; ter Brugge, KG; Willinsky, RA, 2008) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "This complex syndrome is associated with cyclosporine A therapy or a variety of other conditions in which blood pressure rises acutely." | 1.31 | Clinical spectrum of reversible posterior leukoencephalopathy syndrome. ( Koo, J; Kwon, S; Lee, S, 2001) |
| "Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia." | 1.31 | Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002) |
| "In case of fatal hydrocephalus, high lactate levels were observed throughout the whole brain." | 1.30 | In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus. ( Braun, KP; de Graaf, RA; Gooskens, RH; Nicolay, K; Tulleken, KA; Vandertop, WP, 1998) |
| " The optimal dosage of fluconazole and the impact of combination with flucytosine are not known." | 1.29 | Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome. ( Elliott, BR; Kartalija, M; Kaye, K; Liu, Q; Sande, MA; Täuber, MG; Tureen, JH, 1996) |
| "Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors." | 1.29 | Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field. ( Inubushi, T; Ishii, H; Morikawa, S; Shigemori, S; Takahashi, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (11.32) | 18.7374 |
| 1990's | 20 (18.87) | 18.2507 |
| 2000's | 42 (39.62) | 29.6817 |
| 2010's | 30 (28.30) | 24.3611 |
| 2020's | 2 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Duhaut, DE | 1 |
| Heurteaux, C | 1 |
| Gandin, C | 1 |
| Ichai, C | 1 |
| Quintard, H | 1 |
| Kofler, M | 1 |
| Gaasch, M | 1 |
| Rass, V | 1 |
| Schiefecker, AJ | 1 |
| Ianosi, B | 1 |
| Lindner, A | 1 |
| Beer, R | 1 |
| Stover, JF | 2 |
| Rhomberg, P | 1 |
| Pfausler, B | 1 |
| Thomé, C | 2 |
| Schmutzhard, E | 1 |
| Helbok, R | 2 |
| Jiang, YS | 1 |
| Wang, FR | 1 |
| Prazak, J | 1 |
| Laszikova, E | 1 |
| Pantoflicek, T | 1 |
| Ryska, O | 1 |
| Koblihova, E | 1 |
| Ryska, M | 1 |
| Wasser, G | 1 |
| Pattarini, JM | 1 |
| Blue, RS | 1 |
| Aikins, LT | 1 |
| Law, J | 1 |
| Walshe, AD | 1 |
| Garbino, A | 1 |
| Turney, MW | 1 |
| Clark, JB | 1 |
| Chavarria, L | 2 |
| Cordoba, J | 2 |
| Oria, M | 2 |
| Jalan, R | 1 |
| Bosoi, CR | 2 |
| Zwingmann, C | 3 |
| Marin, H | 1 |
| Parent-Robitaille, C | 1 |
| Huynh, J | 1 |
| Tremblay, M | 1 |
| Rose, CF | 3 |
| Ruozi, B | 2 |
| Belletti, D | 2 |
| Forni, F | 2 |
| Sharma, A | 2 |
| Muresanu, D | 1 |
| Mössler, H | 2 |
| Vandelli, MA | 2 |
| Tosi, G | 2 |
| Sharma, HS | 2 |
| Avnstorp, MB | 1 |
| Rasmussen, P | 1 |
| Brassard, P | 1 |
| Seifert, T | 1 |
| Overgaard, M | 1 |
| Krustrup, P | 1 |
| Secher, NH | 1 |
| Nordsborg, NB | 1 |
| Zhu, HT | 1 |
| Bian, C | 1 |
| Yuan, JC | 1 |
| Liao, XJ | 1 |
| Liu, W | 1 |
| Zhu, G | 1 |
| Feng, H | 1 |
| Lin, JK | 1 |
| Muresanu, DF | 1 |
| Tian, R | 1 |
| Han, L | 1 |
| Hou, Z | 1 |
| Hao, S | 1 |
| Mao, X | 1 |
| Zhu, Z | 1 |
| Tao, X | 1 |
| Zhang, Q | 1 |
| Liu, B | 1 |
| Fanning, NF | 1 |
| Willinsky, RA | 1 |
| ter Brugge, KG | 1 |
| Schubert, GA | 1 |
| Poli, S | 1 |
| Schilling, L | 1 |
| Heiland, S | 1 |
| Timaru-Kast, R | 2 |
| Meissner, A | 2 |
| Heimann, A | 3 |
| Hoelper, B | 3 |
| Kempski, O | 4 |
| Alessandri, B | 4 |
| Winter, JD | 1 |
| Tichauer, KM | 1 |
| Gelman, N | 1 |
| Thompson, RT | 1 |
| Lee, TY | 1 |
| St Lawrence, K | 1 |
| Wang, E | 1 |
| Ho, CL | 1 |
| Lee, KK | 1 |
| Ng, I | 1 |
| Ang, BT | 1 |
| Scafidi, S | 1 |
| O'Brien, J | 1 |
| Hopkins, I | 1 |
| Robertson, C | 1 |
| Fiskum, G | 1 |
| McKenna, M | 1 |
| Chernov, MF | 2 |
| Nakaya, K | 1 |
| Kasuya, H | 1 |
| Kato, K | 1 |
| Ono, Y | 2 |
| Yoshida, S | 1 |
| Nakamura, R | 1 |
| Suzuki, T | 1 |
| Muragaki, Y | 1 |
| Iseki, H | 1 |
| Kubo, O | 2 |
| Hori, T | 2 |
| Takakura, K | 2 |
| Lescot, T | 1 |
| Fulla-Oller, L | 2 |
| Po, C | 1 |
| Chen, XR | 1 |
| Puybasset, L | 1 |
| Gillet, B | 1 |
| Plotkine, M | 1 |
| Meric, P | 1 |
| Marchand-Leroux, C | 1 |
| Romero-Gimenez, J | 1 |
| Alonso, J | 1 |
| Lope-Piedrafita, S | 1 |
| Glaser, N | 2 |
| Yuen, N | 2 |
| Anderson, SE | 1 |
| Tancredi, DJ | 1 |
| O'Donnell, ME | 1 |
| Tang, YJ | 1 |
| Zhou, FW | 1 |
| Luo, ZQ | 1 |
| Li, XZ | 1 |
| Yan, HM | 1 |
| Wang, MJ | 1 |
| Huang, FR | 1 |
| Yue, SJ | 1 |
| Keularts, IM | 1 |
| Leroy, PL | 1 |
| Rubio-Gozalbo, EM | 1 |
| Spaapen, LJ | 1 |
| Weber, B | 1 |
| Dorland, B | 1 |
| de Koning, TJ | 1 |
| Verhoeven-Duif, NM | 1 |
| Zetterling, M | 1 |
| Hallberg, L | 1 |
| Hillered, L | 1 |
| Karlsson, T | 1 |
| Enblad, P | 3 |
| Ronne Engström, E | 1 |
| Bjerring, PN | 2 |
| Hauerberg, J | 2 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 2 |
| Tofteng, F | 2 |
| Hansen, BA | 2 |
| Larsen, FS | 3 |
| Salci, K | 2 |
| Goiny, M | 2 |
| Contant, CF | 1 |
| Piper, I | 2 |
| Nilsson, P | 2 |
| Cauli, O | 1 |
| López-Larrubia, P | 1 |
| Rodrigo, R | 1 |
| Agusti, A | 1 |
| Boix, J | 1 |
| Nieto-Charques, L | 1 |
| Cerdán, S | 1 |
| Felipo, V | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 2 |
| Ko, SB | 1 |
| Schmidt, JM | 1 |
| Kurtz, P | 1 |
| Fernandez, L | 1 |
| Choi, HA | 1 |
| Connolly, ES | 1 |
| Lee, K | 1 |
| Badjatia, N | 1 |
| Mayer, SA | 1 |
| Claassen, J | 1 |
| Zweckberger, K | 1 |
| Simunovic, F | 1 |
| Kiening, KL | 2 |
| Unterberg, AW | 2 |
| Sakowitz, OW | 3 |
| Ngo, C | 1 |
| Anderson, S | 1 |
| Trifu, A | 1 |
| O'Donnell, M | 1 |
| Preuss, M | 1 |
| Zhang, J | 1 |
| Deng, Z | 1 |
| Liao, J | 1 |
| Song, C | 1 |
| Liang, C | 1 |
| Xue, H | 1 |
| Wang, L | 1 |
| Zhang, K | 1 |
| Yan, G | 1 |
| Gärdenfors, A | 1 |
| Nilsson, F | 1 |
| Skagerberg, G | 1 |
| Ungerstedt, U | 1 |
| Gliemroth, J | 1 |
| Bahlmann, L | 1 |
| Klaus, S | 1 |
| Klöhn, A | 1 |
| Arnold, H | 1 |
| Chatauret, N | 3 |
| Leibfritz, D | 1 |
| Butterworth, RF | 3 |
| Chen, ZG | 1 |
| Lu, YC | 1 |
| Zhu, C | 1 |
| Zhang, GJ | 1 |
| Ding, XH | 1 |
| Jiang, JY | 1 |
| Rose, C | 2 |
| Beyer, TF | 1 |
| Dohse, NK | 1 |
| Kroppenstedt, SN | 1 |
| Thomale, UW | 1 |
| Schaser, KD | 1 |
| Filippi, R | 1 |
| Kopacz, L | 1 |
| Berger, C | 3 |
| Dohmen, C | 3 |
| Maurer, MH | 1 |
| Graf, R | 3 |
| Schwab, S | 3 |
| Hayashi, M | 1 |
| Izawa, M | 1 |
| Maruyama, T | 1 |
| Usukura, M | 1 |
| Parkin, M | 1 |
| Hopwood, S | 1 |
| Jones, DA | 1 |
| Hashemi, P | 1 |
| Landolt, H | 2 |
| Fabricius, M | 1 |
| Lauritzen, M | 1 |
| Boutelle, MG | 1 |
| Strong, AJ | 1 |
| Alexander, JJ | 1 |
| Quigg, R | 1 |
| Liang, YM | 1 |
| Liu, YS | 1 |
| Qu, HT | 1 |
| Wang, GW | 1 |
| Li, CH | 1 |
| Soustiel, JF | 1 |
| Mahamid, E | 1 |
| Chistyakov, A | 1 |
| Shik, V | 1 |
| Benenson, R | 1 |
| Zaaroor, M | 1 |
| Contant, C | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Reinert, M | 3 |
| Khaldi, A | 1 |
| Zauner, A | 2 |
| Doppenberg, E | 2 |
| Choi, S | 1 |
| Bullock, R | 4 |
| Bosche, B | 1 |
| Reithmeier, T | 1 |
| Ernestus, RI | 1 |
| Brinker, G | 2 |
| Sobesky, J | 1 |
| Heiss, WD | 2 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Geeraerts, T | 1 |
| Friggeri, A | 1 |
| Mazoit, JX | 1 |
| Benhamou, D | 1 |
| Duranteau, J | 1 |
| Vigué, B | 1 |
| Marden, FA | 1 |
| Putman, CM | 1 |
| Jorgensen, L | 1 |
| Katayama, Y | 3 |
| Altman, DI | 1 |
| Young, RS | 1 |
| Yagel, SK | 1 |
| Chan, PH | 1 |
| Yurko, M | 1 |
| Fishman, RA | 1 |
| Imura, Y | 1 |
| Kiyota, Y | 1 |
| Nagai, Y | 1 |
| Nishikawa, K | 1 |
| Terashita, Z | 1 |
| Go, KG | 2 |
| Kamman, RL | 2 |
| Mooyaart, EL | 1 |
| Heesters, MA | 2 |
| Pruim, J | 1 |
| Vaalburg, W | 1 |
| Paans, AM | 1 |
| Kamiya, T | 1 |
| Kashiwagi, F | 1 |
| Terashi, A | 2 |
| Martos, A | 1 |
| Cabellos, C | 1 |
| Martínez-Lacasa, J | 1 |
| Viladrich, PF | 1 |
| Gudiol, F | 1 |
| París, MM | 1 |
| Friedland, IR | 1 |
| Ehrett, S | 1 |
| Hickey, SM | 1 |
| Olsen, KD | 3 |
| Hansen, E | 1 |
| Thonar, EJ | 1 |
| McCracken, GH | 3 |
| Ashwal, S | 2 |
| Perkin, RM | 2 |
| Thompson, JR | 1 |
| Schneider, S | 1 |
| Tomasi, LG | 2 |
| Langemann, H | 1 |
| Mendelowitsch, A | 1 |
| Gratzl, O | 1 |
| Mun-Bryce, S | 1 |
| Kroh, FO | 1 |
| White, J | 1 |
| Rosenberg, GA | 1 |
| de Haan, HH | 1 |
| Van Reempts, JL | 1 |
| Vles, JS | 1 |
| de Haan, J | 1 |
| Hasaart, TH | 1 |
| Mallard, EC | 1 |
| Williams, CE | 1 |
| Johnston, BM | 1 |
| Gluckman, PD | 1 |
| Täuber, MG | 4 |
| Sande, E | 1 |
| Fournier, MA | 1 |
| Tureen, JH | 2 |
| Sande, MA | 4 |
| Kartalija, M | 1 |
| Kaye, K | 1 |
| Liu, Q | 1 |
| Elliott, BR | 1 |
| Staub, F | 2 |
| Winkler, A | 1 |
| Haberstok, J | 1 |
| Plesnila, N | 2 |
| Peters, J | 1 |
| Chang, RC | 1 |
| Baethmann, A | 2 |
| Morikawa, S | 2 |
| Inubushi, T | 2 |
| Takahashi, K | 1 |
| Ishii, H | 2 |
| Shigemori, S | 1 |
| Krikke, AP | 1 |
| Nakamura, T | 1 |
| Nagao, S | 1 |
| Kawai, N | 1 |
| Honma, Y | 1 |
| Kuyama, H | 1 |
| Braun, KP | 1 |
| de Graaf, RA | 1 |
| Vandertop, WP | 1 |
| Gooskens, RH | 1 |
| Tulleken, KA | 1 |
| Nicolay, K | 1 |
| Annecke, A | 1 |
| Aschoff, A | 1 |
| Spranger, M | 1 |
| Yamamura, H | 1 |
| Hiraide, A | 2 |
| Matsuoka, T | 1 |
| Takaoka, M | 1 |
| Shimazu, T | 1 |
| Sugimoto, H | 1 |
| Holshouser, BA | 1 |
| Shu, SK | 1 |
| Simmons, PL | 1 |
| Knierim, DS | 1 |
| Sheridan, C | 1 |
| Craig, K | 1 |
| Andrews, GH | 1 |
| Hinshaw, DB | 1 |
| Son, BC | 1 |
| Park, CK | 1 |
| Choi, BG | 1 |
| Kim, EN | 1 |
| Choe, BY | 1 |
| Lee, KS | 1 |
| Kim, MC | 1 |
| Kang, JK | 1 |
| Schuhmann, MU | 1 |
| Stiller, D | 1 |
| Thomas, S | 1 |
| Brinker, T | 1 |
| Samii, M | 1 |
| Eriskat, J | 1 |
| Stoffel, M | 1 |
| Rinecker, M | 1 |
| Chen, T | 1 |
| Qian, YZ | 1 |
| Di, X | 1 |
| Zhu, JP | 1 |
| Young, HF | 1 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Neveling, M | 1 |
| Kwon, S | 1 |
| Koo, J | 1 |
| Lee, S | 1 |
| Suzuki, M | 2 |
| Sato, K | 1 |
| Dohi, S | 1 |
| Sato, T | 1 |
| Matsuura, A | 1 |
| Therrien, G | 1 |
| Arai, T | 1 |
| Segawa, H | 1 |
| Fukuda, K | 1 |
| Sáez-Llorens, X | 1 |
| Jafari, HS | 1 |
| Severien, C | 1 |
| Parras, F | 1 |
| Hansen, EJ | 1 |
| Singer, II | 1 |
| Bakay, RA | 1 |
| Sweeney, KM | 1 |
| Wood, JH | 1 |
| Shimoda, M | 1 |
| Yamada, S | 1 |
| Yamamoto, I | 1 |
| Tsugane, R | 1 |
| Sato, O | 1 |
| Uenohara, H | 1 |
| Imaizumi, S | 1 |
| Suzuki, J | 1 |
| Yoshimoto, T | 1 |
| Plotnikov, MB | 1 |
| Plotnikova, TM | 1 |
| Iakimova, TV | 1 |
| Saratikov, AS | 1 |
| Borschberg, U | 1 |
| Syrogiannopoulos, GA | 1 |
| Reisch, JS | 1 |
| Shimizu, J | 1 |
| Minamisawa, H | 1 |
| Sugimoto, S | 1 |
| Suzuki, S | 1 |
| Siesjö, BK | 1 |
| Wieloch, T | 1 |
| Khayam-Bashi, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry[NCT01444664] | Phase 4 | 24 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| Ketone Esters for Optimization of Cognitive Performance in Hypoxia[NCT03659825] | 16 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
7 reviews available for lactic acid and Brain Swelling
| Article | Year |
|---|---|
Flat spin and negative Gz in high-altitude free fall: pathophysiology, prevention, and treatment.
Topics: Altitude; Arrhythmias, Cardiac; Blood Glucose; Brain Edema; Cerebrovascular Circulation; Confusion; | 2013 |
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Precl | 2014 |
Increase brain lactate in hepatic encephalopathy: cause or consequence?
Topics: Animals; Biological Transport, Active; Brain Chemistry; Brain Edema; Energy Metabolism; Hepatic Ence | 2010 |
Bacterial meningitis in children: current concepts of neurologic management.
Topics: Adolescent; Adrenal Cortex Hormones; Algorithms; Animals; Anti-Infective Agents; Brain Edema; Cerebr | 1994 |
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A | 1986 |
Cerebral metabolism in ischaemia: neurochemical basis for therapy.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Calcium; Carbon Dioxide; Cerebral Cortex; Energy Metabo | 1985 |
5 trials available for lactic acid and Brain Swelling
| Article | Year |
|---|---|
Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
Topics: Adult; Aged; Analysis of Variance; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Female; Glutam | 2008 |
Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events.
Topics: Adult; Aged; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Ele | 2005 |
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul | 2006 |
The origin of lactate in peritumoral edema as measured by proton-magnetic resonance spectroscopic imaging.
Topics: Brain Edema; Brain Neoplasms; Glioma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Protons | 1997 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
94 other studies available for lactic acid and Brain Swelling
| Article | Year |
|---|---|
The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Intracranial Hypertension; Intracranial Pressure; L | 2021 |
The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients.
Topics: Aged; Aneurysm, Ruptured; Brain; Brain Edema; Brain Ischemia; Cohort Studies; Female; Glucose; Gluta | 2020 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
Ischemic stroke penumbra and extracorporeal ozone treatment.
Topics: Adenosine Triphosphate; Apoptosis; Brain Edema; Disabled Persons; Disease Progression; Glutathione R | 2013 |
Brain lactate in hepatic encephalopathy: friend or foe?
Topics: Animals; Brain; Brain Edema; Hepatic Encephalopathy; Lactic Acid; Liver Diseases; Male | 2014 |
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.
Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Glutamine; Hepatic Encephalopathy; Lactic Aci | 2014 |
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury.
Topics: Analysis of Variance; Animals; Brain Concussion; Brain Edema; Disease Models, Animal; Lactic Acid; M | 2014 |
Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise.
Topics: Acid-Base Equilibrium; Adult; Altitude Sickness; Body Water; Brain; Brain Chemistry; Brain Edema; Ex | 2015 |
Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.
Topics: Altitude; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Glutamic Acid; Hyperbaric Oxygenation; L | 2015 |
PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Delayed-Action Preparations; | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec | 2015 |
Wall enhancement, edema, and hydrocephalus after endovascular coil occlusion of intradural cerebral aneurysms.
Topics: Adult; Aged; Angioplasty; Biocompatible Materials; Brain Edema; Cohort Studies; Embolization, Therap | 2008 |
Hypothermia reduces cytotoxic edema and metabolic alterations during the acute phase of massive SAH: a diffusion-weighted imaging and spectroscopy study in rats.
Topics: Acute Disease; Animals; Aspartic Acid; Body Temperature; Brain; Brain Edema; Cerebral Cortex; Creati | 2008 |
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Evoked Potentials, Somatosensor | 2008 |
Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study.
Topics: Animals; Animals, Newborn; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Disease Models, | 2009 |
Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Edema; Brain Injuries; Glucose; Glutamic Acid; Glutamine; | 2009 |
Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Choline; Female; Humans; Lactic Acid; Lipids; Magnet | 2009 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; | 2010 |
Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Diffusion Tensor Imaging; Glu | 2010 |
Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Bumetanide; Cerebrovascular Circulation; Creatinine; Dia | 2010 |
Multiple therapeutic effects of adjunctive baicalin therapy in experimental bacterial meningitis.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Blood Pressure; Brain Edema; Cere | 2010 |
Fatal cerebral edema associated with serine deficiency in CSF.
Topics: Biomarkers; Blood Glucose; Brain; Brain Edema; Child; Child, Preschool; Energy Metabolism; Fatal Out | 2010 |
Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema.
Topics: Biomarkers; Brain; Brain Chemistry; Brain Edema; Energy Metabolism; Extracellular Fluid; Glucose; Hu | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cerebellum; Cerebrum; En | 2011 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Global cerebral edema and brain metabolism after subarachnoid hemorrhage.
Topics: Brain; Brain Edema; Female; Glucose; Humans; Lactic Acid; Middle Aged; Oxygen; Prospective Studies; | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Evoked Po | 2011 |
Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Edema; Cerebrum; Diabetes Mellitus, Experiment | 2012 |
An energy-failure based brain edema concept.
Topics: Acidosis, Lactic; Animals; Brain Edema; Energy Metabolism; Glucose; Humans; Lactic Acid; Models, Neu | 2012 |
Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway.
Topics: Animals; Brain Edema; Brain Infarction; Chromones; Energy Metabolism; Enzyme Inhibitors; L-Lactate D | 2013 |
Cerebral physiological and biochemical changes during vasogenic brain oedema induced by intrathecal injection of bacterial lipopolysaccharides in piglets.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Escherichia coli; Glucose; Inflammation; Intrac | 2002 |
Long-time microdialysis in a patient with meningoencephalitis.
Topics: Adult; Brain Edema; Combined Modality Therapy; Diuretics, Osmotic; Glucose; Glutamic Acid; Glycerol; | 2002 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Hexosyltransferases; Lactic Aci | 2003 |
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.
Topics: Ammonia; Brain; Brain Edema; Glutamic Acid; Humans; Hypothermia, Induced; Lactic Acid; Liver Failure | 2002 |
Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.
Topics: Amino Acids; Animals; Brain Edema; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral | 2003 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In | 2005 |
Proton MRS of the peritumoral brain.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Edema; Brain Neoplasms; Epilepsy; Female; Huma | 2005 |
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy.
Topics: Alanine; Amino Acids; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Carbon Radioisotopes; | 2005 |
[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
Topics: Animals; Brain Edema; Brain Injuries; Hypothermia, Induced; Lactic Acid; Male; Random Allocation; Ra | 2004 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran | 2000 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Perianeurysm edema with second-generation bioactive coils.
Topics: Adult; Biocompatible Materials; Brain Edema; Embolization, Therapeutic; Female; Humans; Intracranial | 2008 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
[Studies on pathogenesis of cerebral edema due to experimental cerebral hemorrhage. An approach through energy metabolism (author's transl)].
Topics: Adenosine Monophosphate; Animals; Body Water; Brain; Brain Edema; Cerebral Hemorrhage; Cyclic AMP; E | 1982 |
Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain; Brain Edema; Brain Ischemia; Dexamethasone; Dose-Re | 1984 |
Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.
Topics: Animals; Brain Edema; Cerebral Cortex; Dimethyl Sulfoxide; Free Radicals; Lactates; Lactic Acid; Lip | 1982 |
Beneficial effect of CV-4151 (Isbogrel), a thromboxane A2 synthase inhibitor, in a rat middle cerebral artery thrombosis model.
Topics: Animals; Aspirin; Brain Chemistry; Brain Edema; Cerebral Arteries; Cerebral Infarction; Drug Evaluat | 1995 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl | 1995 |
The role of bradykinin in mediating ischemic brain edema in rats.
Topics: Adenosine Triphosphate; Animals; Aprotinin; Blood Pressure; Body Water; Bradykinin; Brain; Brain Ede | 1993 |
[Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis].
Topics: Animals; Brain Edema; Cerebrospinal Fluid Proteins; Dexamethasone; Lactates; Lactic Acid; Leukocyte | 1995 |
Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection.
Topics: Animals; Arthritis, Infectious; Brain Edema; Cerebrospinal Fluid Proteins; Haemophilus Infections; H | 1995 |
Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care.
Topics: Acid-Base Equilibrium; Adult; Ascorbic Acid; Blood Glucose; Blood-Brain Barrier; Brain Edema; Brain | 1994 |
Brain lactate and pH dissociation in edema: 1H- and 31P-NMR in collagenase-induced hemorrhage in rats.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Hydrogen-Ion Concentration; Lactates | 1993 |
Effects of asphyxia on the fetal lamb brain.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Cerebellum; Cerebrovascular Circulation; Female; Fetal | 1993 |
Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Brain; Brain Edema; Carbon Dioxide; Co | 1994 |
Fluid administration, brain edema, and cerebrospinal fluid lactate and glucose concentrations in experimental Escherichia coli meningitis.
Topics: Animals; Brain Edema; Escherichia coli Infections; Fluid Therapy; Glucose; Lactates; Lactic Acid; Me | 1993 |
Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome.
Topics: Animals; Antifungal Agents; Antigens, Fungal; Brain Edema; Cryptococcus neoformans; Drug Therapy, Co | 1996 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field.
Topics: Acidosis; Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Hydrogen-Ion Concentrati | 1996 |
Significance of multimodal cerebral monitoring under moderate therapeutic hypothermia for severe head injury.
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Brain; Brain Edema; Brain Injuries; Child; Child, Pres | 1998 |
In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus.
Topics: Acute Disease; Analysis of Variance; Animals; Brain; Brain Edema; Brain Ischemia; Chronic Disease; D | 1998 |
Neurochemical monitoring of fatal middle cerebral artery infarction.
Topics: Adult; Biomarkers; Brain Edema; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Fatal Outco | 1999 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |
Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury.
Topics: Aspartic Acid; Brain Edema; Chi-Square Distribution; Child; Child, Preschool; Discriminant Analysis; | 2000 |
Metabolic changes in pericontusional oedematous areas in mild head injury evaluated by 1H MRS.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Concussion; Brain Edema; Brain Ischemia; Creati | 2000 |
1H-MR spectroscopic monitoring of posttraumatic metabolism following controlled cortical impact injury: pilot study.
Topics: Animals; Aspartic Acid; Brain Concussion; Brain Edema; Cerebral Cortex; Choline; Creatine; Energy Me | 2000 |
Interstitial lactate in the peritraumatic penumbra of rat brain.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Nec | 2000 |
Evidence for lactate uptake after rat fluid percussion brain injury.
Topics: Animals; Autoradiography; Blood Glucose; Brain; Brain Concussion; Brain Edema; Glycolysis; Lactic Ac | 2000 |
Low extracellular (ECF) glucose affects the neurochemical profile in severe head-injured patients.
Topics: Blood Glucose; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Critical Care; Energy Metabolism; | 2000 |
Substrate delivery and ionic balance disturbance after severe human head injury.
Topics: Acid-Base Equilibrium; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Glutamic Acid; Humans; La | 2000 |
Clinical spectrum of reversible posterior leukoencephalopathy syndrome.
Topics: Adolescent; Adult; Blood-Brain Barrier; Brain Edema; Child; Child, Preschool; Cyclosporine; Diagnosi | 2001 |
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ede | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M | 2002 |
Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Brain Edema; CD18 Antigens; Combined Modality Therapy | 1991 |
Time course of CSF lactate level in subarachnoid haemorrhage. Correlation with clinical grading and prognosis.
Topics: Acid-Base Equilibrium; Adult; Aged; Brain Edema; Brain Ischemia; Coma; Electrolytes; Female; Humans; | 1989 |
The protective effect of mannitol, vitamin E and glucocorticoid on ischaemic brain injury: evaluation by chemiluminescence, energy metabolism and water content.
Topics: Adenine Nucleotides; Animals; Body Water; Brain Edema; Carbohydrate Metabolism; Drug Combinations; E | 1988 |
[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage].
Topics: Animals; Brain; Brain Edema; Carbohydrate Metabolism; Cats; Cerebral Hemorrhage; Cerebrovascular Cir | 1988 |
Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis.
Topics: Animals; Brain Edema; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Granulocytes; Intracranial | 1988 |
Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis.
Topics: Animals; Brain Edema; Ceftriaxone; Cerebrospinal Fluid; Dexamethasone; Drug Therapy, Combination; Ha | 1987 |
[Involvement of arachidonic acid cascade in brain edema and cerebral energy metabolism after reperfusion].
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Body Water; Brain; Brain Edema; Dexamethasone; E | 1987 |
Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis.
Topics: Adrenal Cortex Hormones; Ampicillin; Animals; Body Water; Brain Chemistry; Brain Edema; Dexamethason | 1985 |