lactic acid has been researched along with Brain Neoplasms in 269 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Mannitol and the study drug (furosemide or placebo) were administered, and arterial blood gases with electrolytes (sodium, potassium, and lactic acid) and urine output volume were recorded every 30 minutes for 3 hours." | 9.17 | The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis. ( Bebawy, JF; Gupta, DK; Hemmer, LB; Koht, A; Ramaiah, VK; Zeeni, C, 2013) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 9.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| "Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor." | 7.85 | In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. ( Agliano, A; Al-Saffar, NMS; Balarajah, G; Clarke, PA; Jackson, LE; Jones, C; Leach, MO; Marshall, LV; Pearson, ADJ; Sidhu, J; Workman, P, 2017) |
| "Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma." | 7.81 | Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles. ( Chen, YC; Kuo, YC, 2015) |
| "In this study, we developed and characterized a delivery system for the epigenetic demethylating drug, decitabine, to sensitize temozolomide-resistant human glioblastoma multiforme (GBM) cells to alkylating chemotherapy." | 7.81 | Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide. ( Cui, Y; Irudayaraj, J; Naz, A; Thompson, DH, 2015) |
| " Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells." | 7.80 | New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014) |
| "Polysorbate 80 coated temozolomide-loaded PLGA-based superparamagnetic nanoparticles (P80-TMZ/SPIO-NPs) were successfully synthesized and characterized as drug carriers and diagnosis agent for malignant brain glioma." | 7.78 | Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. ( Ling, Y; Wei, K; Zhong, S; Zou, F, 2012) |
| "Implantable and poly (d,l-lactide-co-glycolide) (PLGA) microparticles were developed to deliver temozolomide (TM) continuously in interstitial chemotherapy for glioma." | 7.77 | Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats. ( Liu, JM; Yue, ZJ; Zhang, H; Zhang, YH, 2011) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 7.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "In an effort to develop new therapeutic strategies to treat malignant gliomas, we have designed poly (lactic-co-glycolic) acid (PLGA) microparticles that deliver imatinib mesylate, a small molecule tyrosine kinase inhibitor." | 7.75 | Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. ( Ariel, G; Benny, O; Black, PM; Carroll, RS; Goren, E; Kim, SK; Machluf, M; Menon, LG; Stewman, C, 2009) |
| "Transferrin (Tf), an iron-transporting serum glycoprotein, which binds to receptors expressed at the surface of most proliferating cells with particularly high expression on erythroblasts and cancer cells, was chosen as the ligand to develop BCNU-loaded biodegradable poly(D,L-lactic acid) nanoparticles (NPs) containing a ligand, which specifically binds to glioma cells, and their anti-tumor ability was evaluated using a C6 glioma model." | 7.75 | Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles. ( Albadany, A; Chang, J; Guo, Y; Kang, C; Li, Y; Pu, P; Sheng, J; Yu, S; Yuan, X; Zhang, Z; Zhong, Y, 2009) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 5.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| " Systemically administered drugs are often poorly bioavailable in the brain, and drug efficacy within the central nervous system can be limited by peripheral toxicity." | 5.42 | Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. ( Berens, ME; Chung, EP; Dhruv, HD; DiPerna, DM; Householder, KT; Sirianni, RW; Wohlleb, GM, 2015) |
| " Unfortunately, despite its appropriate solubilization in vehicle solvents, its poor bioavailability and limited passage of the blood-brain barrier concur to disappointing results requiring the development of new delivery system forms." | 5.39 | Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency. ( Andry, MC; Callewaert, M; Dukic, S; Gafa, V; Molinari, M; Roullin, VG; Van Gulick, L; Vittier, M, 2013) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 5.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| " Mannitol and the study drug (furosemide or placebo) were administered, and arterial blood gases with electrolytes (sodium, potassium, and lactic acid) and urine output volume were recorded every 30 minutes for 3 hours." | 5.17 | The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis. ( Bebawy, JF; Gupta, DK; Hemmer, LB; Koht, A; Ramaiah, VK; Zeeni, C, 2013) |
| "We performed serial (1)H-MRSI examinations to assess intratumoral metabolite intensities in 16 patients receiving high-dose oral tamoxifen monotherapy for recurrent malignant glioma (WHO grade III or IV) as part of a phase II clinical trial." | 5.13 | Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma. ( Arnold, DL; Assina, R; Caramanos, Z; Langleben, A; Leblanc, R; Preul, MC; Sankar, T; Villemure, JG, 2008) |
| " A preclinical technique called deuterium metabolic imaging has successfully imaged the Warburg Effect in vivo in glioblastoma." | 5.01 | New metabolic imaging tools in neuro-oncology. ( Corbin, ZA, 2019) |
| "Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM)." | 4.31 | Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. ( Altieri, R; Barbagallo, GMV; Broggi, G; Busi, F; Caltabiano, R; Caruso, M; Di Rosa, M; Forte, S; Giallongo, C; Li Volti, G; Liso, A; Lolicato, M; Longhitano, L; Mione, MC; Parenti, R; Raciti, G; Tibullo, D; Vicario, N, 2023) |
| "To investigate the effect of lactic acid-induced upregulation of PLEKHA4 expression on biological behaviors of glioma cells and the possible molecular mechanism." | 4.31 | [Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells]. ( Chen, T; Wang, N; Xi, B; Xu, W; Ye, J, 2023) |
| "Nanoparticles containing mixed lipid monolayer shell, biodegradable polymer core and rabies virus glycoprotein (RVG) peptide as brain targeting ligand, were developed for brain targeted delivery of paclitaxel (PTX) to treat malignant glioma." | 3.85 | Targeted delivery of nano-PTX to the brain tumor-associated macrophages. ( Do, L; Dou, H; Payne, G; Rodriguez, J; Tao, Y; Thomas, T; Zou, L, 2017) |
| "Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor." | 3.85 | In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells. ( Agliano, A; Al-Saffar, NMS; Balarajah, G; Clarke, PA; Jackson, LE; Jones, C; Leach, MO; Marshall, LV; Pearson, ADJ; Sidhu, J; Workman, P, 2017) |
| "Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma." | 3.81 | Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles. ( Chen, YC; Kuo, YC, 2015) |
| "In this study, we developed and characterized a delivery system for the epigenetic demethylating drug, decitabine, to sensitize temozolomide-resistant human glioblastoma multiforme (GBM) cells to alkylating chemotherapy." | 3.81 | Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide. ( Cui, Y; Irudayaraj, J; Naz, A; Thompson, DH, 2015) |
| "Fenofibrate, a well-known normolipidemic drug, has been shown to exert strong anticancer effects against tumors of neuroectodermal origin including glioblastoma." | 3.81 | Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier. ( Ayyala, R; Blake, DA; Culicchia, F; Grabacka, M; John, VT; Ponnusamy, T; Reiss, K; Rutkowska, M; Vashistha, H; Waligorski, P; Wilk, A; Wisniewska-Becker, A; Wyczechowska, D; Zapata, A, 2015) |
| " Celecoxib (CXB), a selective COX-2 inhibitor, is able to control inflammation and pain, to improve the efficacy of radiotherapy, and to inhibit at high doses the growth of cancer cells." | 3.80 | New celecoxib multiparticulate systems to improve glioblastoma treatment. ( Barcia, E; Fernández-Carballido, A; García-García, L; Marcianes, P; Negro, S; Slowing, K; Vera, M, 2014) |
| "Polysorbate 80 coated temozolomide-loaded PLGA-based superparamagnetic nanoparticles (P80-TMZ/SPIO-NPs) were successfully synthesized and characterized as drug carriers and diagnosis agent for malignant brain glioma." | 3.78 | Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. ( Ling, Y; Wei, K; Zhong, S; Zou, F, 2012) |
| "Implantable and poly (d,l-lactide-co-glycolide) (PLGA) microparticles were developed to deliver temozolomide (TM) continuously in interstitial chemotherapy for glioma." | 3.77 | Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats. ( Liu, JM; Yue, ZJ; Zhang, H; Zhang, YH, 2011) |
| "To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model." | 3.77 | Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. ( Bok, R; James, CD; Nelson, SJ; Ozawa, T; Park, I; Phillips, JJ; Ronen, SM; Vigneron, DB, 2011) |
| "Temozolomide (TM) has anti-tumor activity in patients with malignant glioma." | 3.76 | Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model. ( Liu, JM; Tang, GS; Wang, Y; Yue, ZJ; Zhang, H; Zhang, YH, 2010) |
| "Transferrin (Tf), an iron-transporting serum glycoprotein, which binds to receptors expressed at the surface of most proliferating cells with particularly high expression on erythroblasts and cancer cells, was chosen as the ligand to develop BCNU-loaded biodegradable poly(D,L-lactic acid) nanoparticles (NPs) containing a ligand, which specifically binds to glioma cells, and their anti-tumor ability was evaluated using a C6 glioma model." | 3.75 | Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles. ( Albadany, A; Chang, J; Guo, Y; Kang, C; Li, Y; Pu, P; Sheng, J; Yu, S; Yuan, X; Zhang, Z; Zhong, Y, 2009) |
| "In an effort to develop new therapeutic strategies to treat malignant gliomas, we have designed poly (lactic-co-glycolic) acid (PLGA) microparticles that deliver imatinib mesylate, a small molecule tyrosine kinase inhibitor." | 3.75 | Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth. ( Ariel, G; Benny, O; Black, PM; Carroll, RS; Goren, E; Kim, SK; Machluf, M; Menon, LG; Stewman, C, 2009) |
| "Direct dialysis could be employed to achieve paclitaxel-loaded PLGA and PLA nanoparticles, which could be internalized by C6 glioma cells and enhance the cytotoxicity of paclitaxel because of its penetration to the cytoplasm and sustained release property." | 3.73 | Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. ( Wang, CH; Xie, J, 2005) |
| "Gliomas can display marked changes in the concentrations of energy metabolism molecules such as creatine (Cr), phosphocreatine (PCr) and lactate, as measured using magnetic resonance spectroscopy (MRS)." | 3.71 | Modeling of pathophysiological coupling between brain electrical activation, energy metabolism and hemodynamics: insights for the interpretation of intracerebral tumor imaging. ( Aubert, A; Benali, H; Costalat, R; Duffau, H, 2002) |
| " Since lonidamine (LND) is believed to reduce tumor glucose utilization by inhibition of the mitochondrially-bound glycolytic enzyme hexokinase (HK), 31P magnetic resonance spectroscopy (MRS) was used to noninvasively follow the effects of LND on both tumor pH and the high-energy phosphate metabolites: ATP, phosphocreatine (PCr) and inorganic phosphate (Pi) in subcutaneous rat 9L gliosarcomas." | 3.70 | Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification. ( Ben-Yoseph, O; Lyons, JC; Ross, BD; Song, CW, 1998) |
| " Spectroscopy is a reliable technique for grading of gliomas when N-acetyl-aspartate/choline and choline/creatine ratios and presence of lipids are used in combination." | 3.69 | Characterization of intracranial mass lesions with in vivo proton MR spectroscopy. ( Chhabra, DK; Gupta, RK; Jain, VK; Pandey, R; Poptani, H; Roy, R, 1995) |
| "For patients with nonresectable glioblastoma (GB) or recurrent GB, we have recently been using an interstitial chemotherapy with biodegradable polylactic acid pellets containing nimustine chloride (ACNU), in combination with superselective arterial ACNU injection, routine irradiation and chemotherapy." | 3.69 | Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma. ( Akai, F; Ioku, M; Iwasaki, H; Kaetsu, I; Kuroda, R; Nakatani, J; Uchiyama, T, 1994) |
| "We report the common characteristics of juvenile pilocytic astrocytomas revealed by proton MR spectroscopy." | 2.40 | Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. ( Ball, WS; Ballard, E; Dunn, RS; Egnaczyk, GF; Holland, SK; Hwang, JH, 1998) |
| "Glioblastoma is a malignant brain tumor with poor prognosis." | 1.91 | Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma. ( Cheng, Q; Dai, Z; Liang, X; Liu, Z; Luo, P; Wang, Z; Wen, Z; Zhang, H; Zhang, J; Zhang, M; Zhang, X, 2023) |
| "Glioma is a common type of malignant brain tumour with high mortality and relapse rate." | 1.56 | Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells. ( Chen, T; Lv, K; Yang, H; Zhu, X, 2020) |
| "High-grade gliomas are associated with poor prognosis." | 1.56 | Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma. ( Antti, H; Asklund, T; Bergenheim, AT; Bergström, P; Björkblom, B; Johansson, M; Jonsson, P; Tabatabaei, P, 2020) |
| "Glioblastoma is the most common and malignant brain tumor, and current therapies confer only modest survival benefits." | 1.51 | Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells. ( Berg, HE; Hvinden, IC; Lundanes, E; Rise, F; Sachse, D; Sandberg, CJ; Skaga, E; Skottvoll, FS; Vik-Mo, EO; Wilson, SR, 2019) |
| "IDH1 mutant gliomas have distinct metabolic and microenvironment characteristics compared with wild type gliomas." | 1.51 | Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. ( Chakhoyan, A; Cloughesy, TF; Ellingson, BM; Everson, RG; Lai, A; Liau, LM; Mareninov, S; Nathanson, DA; Nghiemphu, PL; Pope, WB; Prins, RM; Raymond, C; Salamon, N; Yao, J; Yong, WH, 2019) |
| "We hypothesize that DCA exerts its anticancer effects via depriving cancer of acetate benefits." | 1.51 | Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis. ( Abdel-Aziz, W; Abdel-Latif, HM; Aboonq, MS; Ahmed, NS; Almaramhy, HH; Ayat, M; Baghdadi, H; El Sayed, SM; El-Sawy, SA; Elshazley, M; Ibrahim, W; Mahmoud, AA, 2019) |
| "Fifty-five patients diagnosed with neuroepithelial tumors of Grades I (3 cases), II (11 cases), III (15 cases), and IV (26 cases) were enrolled." | 1.48 | The Significance of Lactate and Lipid Peaks for Predicting Primary Neuroepithelial Tumor Grade with Proton MR Spectroscopy. ( Doi, M; Hoshikawa, M; Nakajima, Y; Nakamura, H; Suzuki, T; Takagi, M; Tanaka, Y; Uchida, M; Yoshida, Y, 2018) |
| "Glioblastoma multiforme is the most lethal type of brain tumor and the established therapy only extends patients survival to approximately one year." | 1.48 | Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment. ( Coelho, MAN; Gosselet, F; Lima, J; Loureiro, JA; Pereira, MC; Ramalho, MJ; Sevin, E, 2018) |
| "Glioma is one of the most common types of brain tumors." | 1.46 | Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy. ( Li, F; Li, H; Shi, W; Xu, Y; Yi, C; Zeng, Q, 2017) |
| "Silver nanoparticles were entrapped inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection and quantification of the cellular uptake by confocal microscopy, both in vitro and in vivo." | 1.43 | A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma. ( Corradini, I; Franchini, MC; Locatelli, E; Matteoli, M; Monaco, I; Passoni, L; Rasile, M; Rodighiero, S; Tamborini, M, 2016) |
| "Metabolic imaging of brain tumors using (13)C Magnetic Resonance Spectroscopy (MRS) of hyperpolarized [1-(13)C] pyruvate is a promising neuroimaging strategy which, after a decade of preclinical success in glioblastoma (GBM) models, is now entering clinical trials in multiple centers." | 1.43 | Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. ( Blough, MD; Cairncross, JG; Chaumeil, MM; Chesnelong, C; Eriksson, P; Luchman, HA; Najac, C; Radoul, M; Ronen, SM; Viswanath, P, 2016) |
| "It is very challenging to treat brain cancer because of the blood-brain barrier (BBB) restricting therapeutic drug or gene to access the brain." | 1.42 | Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. ( Hao, Y; Li, D; Li, H; Meng, D; Shi, J; Wang, L; Zhang, H; Zhang, Y; Zhang, Z; Zhao, Y, 2015) |
| " Systemically administered drugs are often poorly bioavailable in the brain, and drug efficacy within the central nervous system can be limited by peripheral toxicity." | 1.42 | Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma. ( Berens, ME; Chung, EP; Dhruv, HD; DiPerna, DM; Householder, KT; Sirianni, RW; Wohlleb, GM, 2015) |
| "Chaetocin-treated tumors exhibited heightened ROS, pATM, YAP1 and pJNK levels." | 1.40 | Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism. ( Anto, NP; Dixit, D; Ghildiyal, R; Sen, E, 2014) |
| "T98G human brain cancer cells were cultivated and cell culture metabolism was measured on-chip." | 1.40 | Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem. ( Ehret, R; Jobst, G; Kieninger, J; Moser, I; Slotwinski, K; Urban, GA; Wego, M; Weltin, A, 2014) |
| " Unfortunately, despite its appropriate solubilization in vehicle solvents, its poor bioavailability and limited passage of the blood-brain barrier concur to disappointing results requiring the development of new delivery system forms." | 1.39 | Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency. ( Andry, MC; Callewaert, M; Dukic, S; Gafa, V; Molinari, M; Roullin, VG; Van Gulick, L; Vittier, M, 2013) |
| "Gliomas are resistant to radiation therapy, as well as to TNFα induced killing." | 1.39 | ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα. ( Ghildiyal, R; Mehta, VS; Sen, E; Sinha, S, 2013) |
| "The detection of a small number of circulating tumor cells (CTCs) is important, especially in the early stages of cancer." | 1.38 | Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology. ( Allen, PB; Bachoo, R; Ellington, AD; Iqbal, SM; Kim, YT; Li, N; Mahmood, MA; Wan, Y, 2012) |
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| "Celecoxib was incorporated into poly DL-lactide-co-glycolide (PLGA) nanoparticles for antitumor drug delivery." | 1.37 | Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells. ( Jeong, YI; Jin, SG; Jung, S; Jung, TY; Kang, SS; Kim, IY; Kim, TH; Moon, KS; Pei, J, 2011) |
| "Monofocal acute inflammatory demyelination (MAID), which is observable by CT and MRI as a well-enhanced mass lesion with prominent perifocal edema, is very similar to malignant gliomas radiologically, making differential diagnosis of the two pathologies difficult." | 1.37 | Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET. ( Aki, T; Asano, Y; Ito, T; Iwama, T; Miwa, K; Shinoda, J; Takenaka, S; Yokoyama, K, 2011) |
| "Examining the cyst content of brain tumors may contribute in determining the malignancy of the given tumor accompanied by a cyst." | 1.36 | Magnetic resonance spectroscopic imaging associated with analysis of fluid in cystic brain tumors. ( Atçi, B; Demircan, N; Ertürk, AR; Ozener, V; Selçuki, M; Turan, Y; Yurt, A, 2010) |
| "Gliosarcoma is an uncommon variant of glioblastoma multiforme, which is composed of gliomatous and sarcomatous elements." | 1.35 | Giant infantile gliosarcoma: magnetic resonance imaging findings. ( Bulakbasi, N; Chen, L; Kocaoglu, M; Onguru, O; Sanal, HT, 2008) |
| "Paclitaxel was released from the nanoparticles in a biphasic profile with a fast release rate in the first 3 days followed by a slow first-order release." | 1.34 | Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy. ( Dong, Y; Feng, SS, 2007) |
| "Using discriminant analysis, this study found that MR spectroscopy in combination with ADC ratio, rather than ADC value, can improve the ability to differentiate recurrent glioma and radiation injury." | 1.34 | Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging. ( Feng, DC; Li, CF; Liu, H; Zeng, QS; Zhen, JH, 2007) |
| "Gliomas are heterogeneous tumors with increased microvasculature, hypoxia, and necrosis." | 1.33 | Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo. ( Cha, S; Chang, SM; Crawford, F; Graves, EE; Li, X; Nelson, SJ; Vigneron, DB, 2005) |
| "One hundred and four metastatic brain tumors were evaluated by long-echo (TR, 2000 ms; TE, 136 ms) single-voxel volume-selected proton MRS." | 1.33 | Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile. ( Chernov, MF; Hayashi, M; Hori, T; Izawa, M; Ono, Y, 2006) |
| "Gliotoxins are a group of amino acids that are toxic to astrocytes, and are substrates of high-affinity sodium-dependent glutamate transporters." | 1.32 | Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study. ( Brennan, L; Hewage, C; Malthouse, JP; McBean, GJ, 2004) |
| "Combined treatment of primary brain tumors (surgery + postoperative radiotherapy) causes alteration of brain metabolism, even in regions of the brain far from the postoperative tumor bed and receiving relatively low total doses of radiation." | 1.32 | 1H-MR spectroscopy of normal brain tissue before and after postoperative radiotherapy because of primary brain tumors. ( Maciejewski, B; Rutkowski, T; Sokol, M; Tarnawski, R, 2003) |
| "Eighty-five brain metastases in 81 patients were investigated before treatment and 16-18h thereafter." | 1.32 | Early metabolic changes in metastatic brain tumors after Gamma Knife radiosurgery: 1H-MRS study. ( Abe, K; Chernov, MF; Hayashi, M; Hori, T; Izawa, M; Kubo, O; Ono, Y; Usukura, M, 2004) |
| "The diagnosis and therapy of childhood brain tumors, most of which are low grade, can be complicated because of their frequent adjacent location to crucial structures, which limits diagnostic biopsy." | 1.32 | Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors. ( Anthony, DC; Astrakas, LG; Black, PM; De Girolami, U; Tarbell, NJ; Tzika, AA; Zarifi, MK; Zurakowski, D, 2004) |
| "The differential diagnosis between brain abscesses and necrotic tumors such as glioblastomas is sometimes difficult to establish by conventional computed tomography and magnetic resonance imaging." | 1.31 | Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports. ( Harada, M; Kageji, T; Nagahiro, S; Nakaiso, M; Takimoto, O; Uno, M, 2002) |
| "Most of the brain tumors were characterized by strongly reduced total N-acetylaspartyl compounds and marked increases of myo-inositol and choline-containing compounds, consistent with a lack of neuroaxonal tissue and a proliferation of glial cells." | 1.31 | Quantitative proton magnetic resonance spectroscopy of focal brain lesions. ( Dechent, P; Frahm, J; Hanefeld, F; Herms, J; Markakis, E; Maxton, C; Wilken, B, 2000) |
| "The diagnosis of brain tumors after high-dose radiation therapy is frequently limited by the lack of metabolic discrimination available with conventional imaging methods." | 1.31 | Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery. ( Chang, S; Dillon, WP; Graves, EE; Larson, D; McDermott, M; Nelson, SJ; Prados, MD; Verhey, L; Vigneron, DB, 2001) |
| "High-grade brain tumors are known to have a high rate of glucose (Glc) consumption." | 1.31 | High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging. ( Décorps, M; Rémy, C; von Kienlin , M; Ziegler, A, 2001) |
| "Three epidermoid cysts showed only lactate signal." | 1.30 | In vivo single-voxel proton MR spectroscopy in intracranial cystic masses. ( Chang, KH; Han, MC; Han, MH; Jung, HW; Kim, HD; Kim, SH; Seong, SO; Song, IC, 1998) |
| "Children who have brain tumors are at risk for a variety of treatment-related sequelae, including neuropsychological and cognitive impairment, neurologic deficits, and neuroendocrinologic disturbances." | 1.30 | Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site. ( Davis, PC; Morris, R; Padgett, CA; Shapiro, MB; Waldrop, SM, 1998) |
| "Choline signals were increased in tumour margins of high grade gliomas and more diffusely in low grade gliomas." | 1.29 | Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. ( Go, KG; Heesters, MA; Kamman, RL; Mooyaart, EL, 1993) |
| "Higher grades of brain tumors in this study were associated with higher Cho/reference and lower NAA/reference values." | 1.29 | Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy. ( Arai, N; Fujiwara, S; Hara, K; Kayama, T; Kumabe, T; Ono, Y; Sato, K; Shimizu, H; Tominaga, T; Yoshimoto, T, 1996) |
| "Thirteen cases of brain cancer treated by radiation therapy were examined by 1H magnetic resonance spectroscopy and gadolinium-enhanced T1-weighted magnetic resonance imaging and reexamined at 2-month intervals." | 1.29 | Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human brain cancer. Unexpected inverse correlation between the changes in tumor choline level and post-gadolinium magnetic resonance imaging contrast. ( Levendag, PC; Oudkerk, M; Sijens, PE; van Dijk, P; Vecht, CJ, 1995) |
| "Choline values were lower in chronic radiation necrosis than in solid anaplastic tumors (P < ." | 1.28 | Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance. ( Alger, JR; Bizzi, A; Di Chiro, G; Dietz, MJ; Dwyer, AJ; Frank, JA; Fulham, MJ; Raman, R; Shih, HH; Sobering, GS, 1992) |
| "Experimental brain tumors were produced in rats by stereotactical implantation of various neoplastic cell lines (RG 2, RG1 2." | 1.27 | Regional metabolism of experimental brain tumors. ( Dolan, E; Hossmann, KA; Mies, G; Paschen, W; Szabo, L; Wechsler, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (1.86) | 18.7374 |
| 1990's | 41 (15.24) | 18.2507 |
| 2000's | 77 (28.62) | 29.6817 |
| 2010's | 119 (44.24) | 24.3611 |
| 2020's | 27 (10.04) | 2.80 |
| Authors | Studies |
|---|---|
| Su, X | 1 |
| Yang, Y | 1 |
| Yang, Q | 1 |
| Pang, B | 1 |
| Sun, S | 1 |
| Wang, Y | 2 |
| Qiao, Q | 1 |
| Guo, C | 1 |
| Liu, H | 5 |
| Pang, Q | 1 |
| Obukhova, LМ | 1 |
| Nikiforova, ОN | 1 |
| Kopytova, ТV | 1 |
| Orlinskaya, NY | 1 |
| Kontorshchikov, ММ | 1 |
| Kontorshchikova, KN | 1 |
| Medyanik, IА | 1 |
| Grishin, АS | 1 |
| Vasina, DD | 1 |
| Udawant, S | 1 |
| Litif, C | 1 |
| Lopez, A | 1 |
| Gunn, B | 1 |
| Schuenzel, E | 1 |
| Keniry, M | 1 |
| Longhitano, L | 1 |
| Vicario, N | 1 |
| Forte, S | 1 |
| Giallongo, C | 1 |
| Broggi, G | 1 |
| Caltabiano, R | 1 |
| Barbagallo, GMV | 1 |
| Altieri, R | 1 |
| Raciti, G | 1 |
| Di Rosa, M | 1 |
| Caruso, M | 1 |
| Parenti, R | 1 |
| Liso, A | 1 |
| Busi, F | 1 |
| Lolicato, M | 1 |
| Mione, MC | 1 |
| Li Volti, G | 1 |
| Tibullo, D | 1 |
| Vassilieva, A | 1 |
| Møller, K | 1 |
| Skjøth-Rasmussen, J | 1 |
| Sørensen, MK | 1 |
| Guyon, J | 1 |
| Fernandez-Moncada, I | 1 |
| Larrieu, CM | 1 |
| Bouchez, CL | 1 |
| Pagano Zottola, AC | 1 |
| Galvis, J | 1 |
| Chouleur, T | 1 |
| Burban, A | 1 |
| Joseph, K | 1 |
| Ravi, VM | 1 |
| Espedal, H | 2 |
| Røsland, GV | 1 |
| Daher, B | 1 |
| Barre, A | 1 |
| Dartigues, B | 1 |
| Karkar, S | 1 |
| Rudewicz, J | 1 |
| Romero-Garmendia, I | 1 |
| Klink, B | 1 |
| Grützmann, K | 1 |
| Derieppe, MA | 1 |
| Molinié, T | 1 |
| Obad, N | 2 |
| Léon, C | 1 |
| Seano, G | 1 |
| Miletic, H | 2 |
| Heiland, DH | 1 |
| Marsicano, G | 1 |
| Nikolski, M | 1 |
| Bjerkvig, R | 2 |
| Bikfalvi, A | 2 |
| Daubon, T | 1 |
| Bazi Alahri, M | 1 |
| Jibril Ibrahim, A | 1 |
| Barani, M | 1 |
| Arkaban, H | 1 |
| Shadman, SM | 1 |
| Salarpour, S | 1 |
| Zarrintaj, P | 1 |
| Jaberi, J | 1 |
| Turki Jalil, A | 1 |
| Wang, Z | 1 |
| Dai, Z | 1 |
| Zhang, H | 5 |
| Liang, X | 1 |
| Zhang, X | 2 |
| Wen, Z | 1 |
| Luo, P | 1 |
| Zhang, J | 3 |
| Liu, Z | 2 |
| Zhang, M | 2 |
| Cheng, Q | 1 |
| Capasso, R | 1 |
| Negro, A | 1 |
| Russo, C | 1 |
| Zeccolini, F | 1 |
| Muto, G | 1 |
| Caranci, F | 1 |
| Pinto, A | 1 |
| Ye, J | 1 |
| Xu, W | 1 |
| Xi, B | 1 |
| Wang, N | 1 |
| Chen, T | 2 |
| Ma, S | 1 |
| Lee, H | 1 |
| Jo, WY | 1 |
| Byun, YH | 1 |
| Shin, KW | 1 |
| Choi, S | 1 |
| Oh, H | 1 |
| Park, CK | 1 |
| Park, HP | 1 |
| Maldonado, F | 1 |
| Fábregas, N | 1 |
| Aldecoa, I | 1 |
| González, J | 1 |
| García-Orellana, M | 1 |
| Belda, I | 1 |
| Hurtado, P | 1 |
| Gracia, I | 1 |
| de Riva, N | 1 |
| Tercero, J | 1 |
| Carrero, E | 1 |
| Valero, R | 1 |
| Corbin, ZA | 1 |
| Branco, M | 1 |
| Linhares, P | 1 |
| Carvalho, B | 1 |
| Santos, P | 1 |
| Costa, BM | 1 |
| Vaz, R | 1 |
| Ni, W | 1 |
| Xia, Y | 2 |
| Luo, L | 1 |
| Wen, F | 1 |
| Hu, D | 1 |
| Bi, Y | 1 |
| Qi, J | 1 |
| Björkblom, B | 1 |
| Jonsson, P | 1 |
| Tabatabaei, P | 1 |
| Bergström, P | 1 |
| Johansson, M | 1 |
| Asklund, T | 1 |
| Bergenheim, AT | 2 |
| Antti, H | 1 |
| Qu, C | 1 |
| Yan, C | 1 |
| Cao, W | 1 |
| Li, F | 3 |
| Qu, Y | 1 |
| Guan, K | 1 |
| Si, C | 1 |
| Yu, Z | 1 |
| Qu, Z | 1 |
| Datta, K | 1 |
| Lauritzen, MH | 1 |
| Merchant, M | 2 |
| Jang, T | 2 |
| Liu, SC | 2 |
| Hurd, R | 1 |
| Recht, L | 1 |
| Spielman, DM | 2 |
| Azzalin, A | 1 |
| Brambilla, F | 1 |
| Arbustini, E | 1 |
| Basello, K | 1 |
| Speciani, A | 1 |
| Mauri, P | 1 |
| Bezzi, P | 1 |
| Magrassi, L | 1 |
| Xue, W | 1 |
| Xu, K | 1 |
| Yi, L | 1 |
| Guo, Y | 2 |
| Xie, T | 1 |
| Tong, H | 1 |
| Zhou, B | 1 |
| Wang, S | 2 |
| Li, Q | 1 |
| Chen, X | 2 |
| Fang, J | 1 |
| Zhang, W | 1 |
| Bisdas, S | 1 |
| Schäfer, R | 1 |
| Kolb, R | 1 |
| Bender, B | 1 |
| Klose, U | 1 |
| Palma, A | 1 |
| Grande, S | 1 |
| Ricci-Vitiani, L | 1 |
| Luciani, AM | 1 |
| Buccarelli, M | 1 |
| Biffoni, M | 1 |
| Dini, V | 1 |
| Cirrone, GAP | 1 |
| Ciocca, M | 1 |
| Guidoni, L | 1 |
| Pallini, R | 1 |
| Viti, V | 1 |
| Rosi, A | 1 |
| Zhu, X | 1 |
| Yang, H | 1 |
| Lv, K | 1 |
| Kubelt, C | 1 |
| Peters, S | 1 |
| Ahmeti, H | 1 |
| Huhndorf, M | 1 |
| Huber, L | 1 |
| Cohrs, G | 1 |
| Hövener, JB | 1 |
| Jansen, O | 1 |
| Synowitz, M | 1 |
| Held-Feindt, J | 1 |
| Viswanath, P | 2 |
| Batsios, G | 1 |
| Mukherjee, J | 1 |
| Gillespie, AM | 1 |
| Larson, PEZ | 4 |
| Luchman, HA | 2 |
| Phillips, JJ | 2 |
| Costello, JF | 1 |
| Pieper, RO | 1 |
| Ronen, SM | 4 |
| Perrillat-Mercerot, A | 2 |
| Miranville, A | 2 |
| Agosti, A | 1 |
| Rocca, E | 1 |
| Ciarletta, P | 1 |
| Guillevin, R | 4 |
| Mishkovsky, M | 1 |
| Gusyatiner, O | 1 |
| Lanz, B | 1 |
| Cudalbu, C | 1 |
| Vassallo, I | 1 |
| Hamou, MF | 1 |
| Bloch, J | 1 |
| Comment, A | 1 |
| Gruetter, R | 2 |
| Hegi, ME | 1 |
| Reuss, AM | 1 |
| Groos, D | 1 |
| Buchfelder, M | 1 |
| Savaskan, N | 1 |
| Inoue, A | 1 |
| Nishikawa, M | 1 |
| Ohnishi, T | 1 |
| Yano, H | 1 |
| Kanemura, Y | 1 |
| Ohtsuka, Y | 1 |
| Ozaki, S | 1 |
| Nakamura, Y | 1 |
| Matsumoto, S | 2 |
| Suehiro, S | 1 |
| Yamashita, D | 1 |
| Shigekawa, S | 1 |
| Watanabe, H | 1 |
| Kitazawa, R | 1 |
| Tanaka, J | 1 |
| Kunieda, T | 1 |
| Huang, WC | 1 |
| Lu, IL | 1 |
| Chiang, WH | 1 |
| Lin, YW | 1 |
| Tsai, YC | 1 |
| Chen, HH | 1 |
| Chang, CW | 1 |
| Chiang, CS | 1 |
| Chiu, HC | 1 |
| Cata, JP | 1 |
| Bhavsar, S | 1 |
| Hagan, KB | 1 |
| Arunkumar, R | 1 |
| Grasu, R | 1 |
| Dang, A | 1 |
| Carlson, R | 1 |
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| Popat, K | 1 |
| Rao, G | 1 |
| Potylchansky, Y | 1 |
| Lipski, I | 1 |
| Ratty, S | 1 |
| Nguyen, AT | 1 |
| McHugh, T | 1 |
| Feng, L | 1 |
| Rahlfs, TF | 1 |
| Son, MJ | 1 |
| Ryu, JS | 1 |
| Kim, JY | 1 |
| Kwon, Y | 1 |
| Chung, KS | 1 |
| Mun, SJ | 1 |
| Cho, YS | 1 |
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| Agliano, A | 1 |
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| Li, H | 4 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies[NCT05145049] | 110 participants (Actual) | Observational [Patient Registry] | 2021-11-01 | Completed | |||
| Effect of Fatty Liver on TCA Cycle Flux and the Pentose Phosphate Pathway (HP FFF)[NCT03480594] | 30 participants (Anticipated) | Observational | 2018-10-01 | Enrolling by invitation | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Development of Magnetic Resonance Spectroscopy (MRS) Biomarkers of Tumor Metabolism[NCT01138813] | 8 participants (Actual) | Observational | 2009-03-31 | Completed | |||
| Comparison of Mannitol Alone Versus Different Doses of Mannitol in Combination With Furosemide on Brain Relaxation in Supratentorial Mass Resection Surgery[NCT02712476] | 47 participants (Actual) | Interventional | 2013-07-31 | Completed | |||
| Study of Clinical Biomarkers in Human Health and Disease (Healthiomics)[NCT05106725] | 3,500 participants (Anticipated) | Observational | 2021-10-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for lactic acid and Brain Neoplasms
| Article | Year |
|---|---|
Management of Brain Cancer and Neurodegenerative Disorders with Polymer-Based Nanoparticles as a Biocompatible Platform.
Topics: Blood-Brain Barrier; Brain Neoplasms; Drug Carriers; Drug Delivery Systems; Humans; Lactic Acid; Nan | 2023 |
Conventional and Advanced MRI Techniques in the Evaluation of Primary CNS Lymphoma.
Topics: Brain Neoplasms; Humans; Lactic Acid; Lymphoma; Magnetic Resonance Imaging | 2023 |
New metabolic imaging tools in neuro-oncology.
Topics: Brain Neoplasms; Deuterium; Glioblastoma; Glycolysis; Humans; Lactic Acid; Medical Oncology; Multimo | 2019 |
The Acidic Brain-Glycolytic Switch in the Microenvironment of Malignant Glioma.
Topics: Animals; Brain; Brain Chemistry; Brain Neoplasms; Carbonic Anhydrases; Glioma; Glycolysis; Humans; H | 2021 |
Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Drug Carriers; Enzyme Replacement Therapy; Genetic Th | 2013 |
Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas.
Topics: Animals; Brain Neoplasms; Carbonic Anhydrases; Glioblastoma; Glycolysis; Humans; Hydrogen-Ion Concen | 2016 |
[Magnetic resonance spectroscopy for cerebral imaging].
Topics: Apoptosis; Aspartic Acid; Asphyxia Neonatorum; Biomarkers, Tumor; Brain; Brain Diseases; Brain Disea | 2010 |
3 Tesla magnetic resonance spectroscopy: cerebral gliomas vs. metastatic brain tumors. Our experience and review of the literature.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differ | 2013 |
Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism.
Topics: Alanine; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Glutamic Acid; Glutamine; Humans | 2004 |
[MRS for diagnosis of brain tumors].
Topics: Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Humans; Image Enhancement; Lactic Acid; | 2005 |
Proton MR spectroscopy of the brain at 3 T: an update.
Topics: Artifacts; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Cerebral Cortex; Choline; Creatine | 2007 |
New methods for direct delivery of chemotherapy for treating brain tumors.
Topics: Antineoplastic Agents; Biocompatible Materials; Brain Neoplasms; Clinical Trials as Topic; Drug Carr | 2006 |
Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas.
Topics: Aspartic Acid; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Choline; Humans; Infant; Lacti | 1998 |
Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Energy Metabolism; Glioblastoma; Humans; Lactates; | 1992 |
Cyclic nucleotides in stroke and related cerebrovascular disorders.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adenylyl Cyclas | 1985 |
5 trials available for lactic acid and Brain Neoplasms
| Article | Year |
|---|---|
Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Choline; Crea | 2014 |
Prospective serial proton MR spectroscopic assessment of response to tamoxifen for recurrent malignant glioma.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dis | 2008 |
The effect of furosemide on intravascular volume status and electrolytes in patients receiving mannitol: an intraoperative safety analysis.
Topics: Adult; Aged; Arterial Pressure; Blood Volume; Brain Neoplasms; Crystalloid Solutions; Diuretics; Dou | 2013 |
The origin of lactate in peritumoral edema as measured by proton-magnetic resonance spectroscopic imaging.
Topics: Brain Edema; Brain Neoplasms; Glioma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Protons | 1997 |
[Is the combination of nitrous oxide and hyperventilation in elective neurosurgical operations useful?].
Topics: Adult; Aged; Anesthesia, General; Brain; Brain Neoplasms; Carbon Dioxide; Female; Humans; Lactic Aci | 2000 |
249 other studies available for lactic acid and Brain Neoplasms
| Article | Year |
|---|---|
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain; Brain Neoplasms; Cell Line, Tumor; Forkhe | 2021 |
Relationship of Carbohydrate Metabolism and Molecular Genetic Markers in Gliomas with Different Degree of Anaplasia.
Topics: Adult; Anaplasia; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Carbohydrate Metabolism; DNA | 2021 |
PI3K Pathway Inhibition with NVP-BEZ235 Hinders Glycolytic Metabolism in Glioblastoma Multiforme Cells.
Topics: Brain Neoplasms; Cell Line, Tumor; Forkhead Box Protein O1; Gene Expression Regulation, Neoplastic; | 2021 |
Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Hedgehog Proteins; Humans; Insulin-Like Gr | 2023 |
Hyperlactatemia associated with elective tumor craniotomy: Protocol for an observational study of pathophysiology and clinical implications.
Topics: Brain Neoplasms; Craniotomy; Humans; Hyperlactatemia; Insulin Resistance; Lactic Acid; Observational | 2022 |
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.
Topics: Animals; Brain Neoplasms; Glioblastoma; Lactate Dehydrogenases; Lactic Acid; Metabolomics; Mice | 2022 |
Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma.
Topics: Brain Neoplasms; CD8-Positive T-Lymphocytes; Glioblastoma; Humans; Immunosuppressive Agents; Lactic | 2023 |
[Lactate-induced up-regulation of PLEKHA4 promotes proliferation and apoptosis of human glioma cells].
Topics: Animals; Apoptosis; beta Catenin; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expres | 2023 |
The Warburg effect in patients with brain tumors: a comprehensive analysis of clinical significance.
Topics: Brain Neoplasms; Clinical Relevance; Humans; Hyperlactatemia; Lactic Acid; Retrospective Studies | 2023 |
Association between preoperative serum lactate concentrate with tumor cell proliferative index in primary brain tumor.
Topics: Brain Neoplasms; Cross-Sectional Studies; Glioma; Humans; Ki-67 Antigen; Lactic Acid; Meningeal Neop | 2022 |
Serum lactate levels are associated with glioma malignancy grade.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Lactic Acid; Male; Middle Aged; Neo | 2019 |
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production.
Topics: Adolescent; Adult; Aldehyde Oxidoreductases; Animals; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; | 2020 |
Metabolic response patterns in brain microdialysis fluids and serum during interstitial cisplatin treatment of high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain; Brain Neoplasms; Cisplatin; Female; Gl | 2020 |
miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1.
Topics: Adenosine Triphosphate; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Gene Expre | 2020 |
Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model.
Topics: Animals; Antineoplastic Agents, Immunological; Bicarbonates; Biomarkers; Brain; Brain Neoplasms; Gli | 2019 |
A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation.
Topics: Adaptation, Physiological; Benzimidazoles; Brain Neoplasms; Cell Line, Tumor; Endocytosis; Glioblast | 2020 |
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Brain; Brain Neopla | 2020 |
Lactate as clinical tumour biomarker: Optimization of lactate detection and quantification in MR spectroscopic imaging of glioblastomas.
Topics: Adult; Aged; Biomarkers, Tumor; Brain; Brain Neoplasms; Feasibility Studies; Female; Glioblastoma; H | 2020 |
Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions.
Topics: Brain Neoplasms; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; gamma-Aminobutyric Acid; Gliobla | 2020 |
Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Move | 2020 |
Intratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers.
Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Disease Progression; Epithelial-M | 2020 |
Non-invasive assessment of telomere maintenance mechanisms in brain tumors.
Topics: Alanine; Animals; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Genetic Eng | 2021 |
Partial differential model of lactate neuro-energetics: analytic results and numerical simulations.
Topics: Brain Neoplasms; Diffusion; Humans; Kinetics; Lactic Acid; Models, Biological; Models, Theoretical | 2021 |
Hyperpolarized
Topics: Aerobiosis; Animals; Aspartic Acid; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Glioblastoma | 2021 |
Prediction of Glioma Stemlike Cell Infiltration in the Non-Contrast-Enhancing Area by Quantitative Measurement of Lactate on Magnetic Resonance Spectroscopy in Glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherap | 2021 |
Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma.
Topics: Adipocytes; Animals; Antineoplastic Agents; Biological Transport; Blood-Brain Barrier; Brain Neoplas | 2017 |
Age, choline-to-N-acetyl aspartate, and lipids-lactate-to-creatine ratios assemble a significant Cox's proportional-hazards regression model for survival prediction in patients with high-grade gliomas.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Creatine; Glioma; Humans; Lactic Acid; Lipids; Magnetic Res | 2017 |
Intraoperative serum lactate is not a predictor of survival after glioblastoma surgery.
Topics: Adult; Aged; Brain Neoplasms; Disease-Free Survival; Female; Glioblastoma; Humans; Lactic Acid; Male | 2017 |
Upregulation of mitochondrial NAD
Topics: Aging; Animals; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Colony-Forming Units Assay; | 2017 |
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor | 2017 |
Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Culture Med | 2017 |
The Significance of Lactate and Lipid Peaks for Predicting Primary Neuroepithelial Tumor Grade with Proton MR Spectroscopy.
Topics: Adult; Aged; Brain Neoplasms; Female; Humans; Lactic Acid; Lipid Metabolism; Lipids; Magnetic Resona | 2018 |
A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.
Topics: Amino Acid Sequence; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Fluore | 2017 |
Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma.
Topics: Animals; Antimetabolites; Antineoplastic Agents, Immunological; Bevacizumab; Brain Neoplasms; Cell D | 2018 |
Online
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Disease Models, Animal; Female; Glioma; Lactic Acid | 2018 |
Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment.
Topics: Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell P | 2018 |
Comparison between cerebrospinal fluid and serum lactate concentrations in neurologic dogs with and without structural intracranial disease.
Topics: Animals; Brain Neoplasms; Cysts; Dog Diseases; Dogs; Epilepsy; Lactic Acid; Meningoencephalitis; Oti | 2018 |
Measuring the lactate-to-creatine ratio via
Topics: Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Creatine; DNA Damage; Electrop | 2018 |
Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics.
Topics: Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Ce | 2018 |
Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain Neoplasms; Gene Expression Profiling; Gene Expression R | 2019 |
Post-resection treatment of glioblastoma with an injectable nanomedicine-loaded photopolymerizable hydrogel induces long-term survival.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Delayed-Ac | 2018 |
Spatially Resolved Bioenergetic and Genetic Reprogramming Through the Brain of Rats Bearing Implanted C6 Gliomas As Detected by Multinuclear High-Resolution Magic Angle Spinning and Genomic Analysis.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biopsy; Brain Neoplasms; Carbon Isotopes; Cau | 2018 |
Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.
Topics: Artifacts; Bicarbonates; Brain; Brain Neoplasms; Calibration; Carbon Isotopes; Carbon-13 Magnetic Re | 2019 |
Analysis of a mathematical model for brain lactate kinetics.
Topics: Brain; Brain Neoplasms; Capillaries; Computer Simulation; Energy Metabolism; Glioma; Humans; Intrace | 2018 |
Short-acquisition-time JPRESS and its application to paediatric brain tumours.
Topics: Adult; Biomarkers, Tumor; Brain; Brain Neoplasms; Child; Female; Glycine; Healthy Volunteers; Humans | 2019 |
Development of Nanoparticles for Drug Delivery to Brain Tumor: The Effect of Surface Materials on Penetration Into Brain Tissue.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Drug Delive | 2019 |
Dichloroacetate is an antimetabolite that antagonizes acetate and deprives cancer cells from its benefits: A novel evidence-based medical hypothesis.
Topics: Acetates; Acetyl Coenzyme A; Animals; Antineoplastic Agents; Brain Neoplasms; Chlorides; Dichloroace | 2019 |
Verteporfin-Loaded Polymeric Microparticles for Intratumoral Treatment of Brain Cancer.
Topics: Animals; Brain Neoplasms; Glioblastoma; Humans; Lactic Acid; Male; Mice; Mice, Nude; Microspheres; P | 2019 |
Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Brain Neoplasms; Cell Survival; Citric Acid; Cit | 2019 |
Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Gl | 2019 |
Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.
Topics: Brain; Brain Neoplasms; Carbon Isotopes; Echo-Planar Imaging; Humans; Image Interpretation, Computer | 2020 |
ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Ataxi | 2013 |
Body mass index as a risk factor for increased serum lactate during craniotomy.
Topics: Adult; Aged; Blood Gas Analysis; Body Mass Index; Brain Neoplasms; Craniotomy; Female; Humans; Lacti | 2013 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1α.
Topics: Adenosine Triphosphate; Blotting, Western; Brain Neoplasms; Energy Metabolism; Glioma; Glucose; Glyc | 2013 |
Magnetic resonance imaging spectroscopy in pediatric atypical teratoid rhabdoid tumors of the brain.
Topics: Brain; Brain Neoplasms; Child, Preschool; Choline; Chromosomal Proteins, Non-Histone; Creatine; Diag | 2014 |
Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix.
Topics: Animals; Brain Neoplasms; Cell Death; Cell Line, Tumor; Chemotherapy, Adjuvant; Drug Delivery System | 2013 |
Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem.
Topics: Antineoplastic Agents; Biological Transport; Biosensing Techniques; Brain Neoplasms; Cell Culture Te | 2014 |
iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas.
Topics: Administration, Intravenous; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Collage | 2014 |
Brain-targeted delivery of doxorubicin using glutathione-coated nanoparticles for brain cancers.
Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Doxoru | 2015 |
Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apopto | 2014 |
Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorou | 2014 |
Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo.
Topics: Adult; Aged; Artifacts; Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; | 2015 |
New celecoxib multiparticulate systems to improve glioblastoma treatment.
Topics: Animals; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibito | 2014 |
Serum lactate as a potential biomarker of malignancy in primary adult brain tumours.
Topics: Adult; Aged; Biomarkers; Brain Neoplasms; Craniotomy; Disease Progression; Female; Glycolysis; Human | 2015 |
Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Diffusion Magnetic Resonance Ima | 2015 |
Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Brain Neoplasms; Disease Mo | 2014 |
Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Brain Neoplasms; Delayed-Ac | 2014 |
Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.
Topics: Adult; Aged; Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Brain | 2015 |
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Convection; Drug Delivery Systems; Ferric Compounds | 2015 |
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth.
Topics: Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Dichloroacetic Acid; Glyco | 2014 |
Development of disulfiram-loaded poly(lactic-co-glycolic acid) wafers for the localised treatment of glioblastoma multiforme: a comparison of manufacturing techniques.
Topics: Antineoplastic Agents; Brain Neoplasms; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell S | 2015 |
Targeting delivery of etoposide to inhibit the growth of human glioblastoma multiforme using lactoferrin- and folic acid-grafted poly(lactide-co-glycolide) nanoparticles.
Topics: Antineoplastic Agents, Phytogenic; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumo | 2015 |
Intravenous delivery of camptothecin-loaded PLGA nanoparticles for the treatment of intracranial glioma.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; Brain Neoplasms; Camptothecin; Drug | 2015 |
Evaluation of lactate detection using selective multiple quantum coherence in phantoms and brain tumours.
Topics: Brain; Brain Neoplasms; Humans; Lactic Acid; Lipids; Magnetic Resonance Imaging; Metabolome; Phantom | 2015 |
Decitabine nanoconjugate sensitizes human glioblastoma cells to temozolomide.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Biocompa | 2015 |
Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.
Topics: Brain Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cell Hypoxia; Choline; Female; Humans; Lactic | 2015 |
Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles.
Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Combinations; Glioma | 2015 |
Fenofibrate subcellular distribution as a rationale for the intracranial delivery through biodegradable carrier.
Topics: Animals; Biodegradable Plastics; Brain; Brain Neoplasms; Cell Line, Tumor; Drug Carriers; Female; Fe | 2015 |
Serum lactate as a potential biomarker of non-glial brain tumors.
Topics: Biomarkers; Brain Neoplasms; Female; Glycolysis; Humans; Lactic Acid; Male; Neoplasm Recurrence, Loc | 2015 |
Targeted Imaging and Chemo-Phototherapy of Brain Cancer by a Multifunctional Drug Delivery System.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Docetaxel; Drug Delivery Systems; Glioma; Humans; Lactic | 2015 |
Ultrasmall Gold Nanorod Vesicles with Enhanced Tumor Accumulation and Fast Excretion from the Body for Cancer Therapy.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Gold; Humans; Kinetics; Lactic Acid; Mice; Nanotubes; Ph | 2015 |
Hot melt extruded and injection moulded disulfiram-loaded PLGA millirods for the treatment of glioblastoma multiforme via stereotactic injection.
Topics: Brain Neoplasms; Cell Line, Tumor; Disulfiram; Drug Carriers; Drug Delivery Systems; Freezing; Gliob | 2015 |
A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation To Reach Infiltrating Tumor Niches in Glioblastoma.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Chemoradiotherapy; Chloride Channel | 2016 |
Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy.
Topics: Algorithms; Animals; Brain Chemistry; Brain Neoplasms; Cell Line, Tumor; Diffusion Magnetic Resonanc | 2017 |
Hyperpolarized (13)C-lactate to (13)C-bicarbonate ratio as a biomarker for monitoring the acute response of anti-vascular endothelial growth factor (anti-VEGF) treatment.
Topics: Animals; Bicarbonates; Biomarkers, Tumor; Brain Neoplasms; Carbon Isotopes; Cell Count; Cell Prolife | 2016 |
Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate.
Topics: Acetates; Brain Neoplasms; Carbon Isotopes; Gluconeogenesis; Humans; Lactic Acid; Liver; Magnetic Re | 2016 |
Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Convection; Drug Delivery Systems; Glioblastoma; | 2016 |
Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry.
Topics: Brain; Brain Neoplasms; Chlorides; Glioblastoma; Glutarates; Humans; Lactic Acid; Maleic Anhydrides; | 2016 |
Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.
Topics: Biomarkers, Tumor; Brain Neoplasms; Carbon-13 Magnetic Resonance Spectroscopy; Glioma; Humans; Isoci | 2016 |
A rapid inversion technique for the measurement of longitudinal relaxation times of brain metabolites: application to lactate in high-grade gliomas at 3 T.
Topics: Algorithms; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Image Enhancement; Image Interpretat | 2016 |
Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tum | 2016 |
Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Brain; Brain Neoplasms; Camptoth | 2016 |
Validating a robust double-quantum-filtered (1) H MRS lactate measurement method in high-grade brain tumours.
Topics: Algorithms; Biomarkers, Tumor; Brain Neoplasms; Humans; Lactic Acid; Magnetic Resonance Imaging; Mol | 2016 |
Choline-to-N-acetyl aspartate and lipids-lactate-to-creatine ratios together with age assemble a significant Cox's proportional-hazards regression model for prediction of survival in high-grade gliomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain Neoplasms; Choline; Cre | 2016 |
Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Curcumin; Drug Delivery Systems; Glioma; Lactic Acid; Mi | 2016 |
Serum Lactate is a Biomarker of Brain Tumor Metabolism.
Topics: Biomarkers; Brain; Brain Neoplasms; Humans; Lactates; Lactic Acid | 2017 |
Targeted delivery of nano-PTX to the brain tumor-associated macrophages.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cell L | 2017 |
Assessment of alterations in X-ray irradiation-induced DNA damage of glioma cells by using proton nuclear magnetic resonance spectroscopy.
Topics: Apoptosis; Astrocytes; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Choline; Creati | 2017 |
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Aromatase Inhibitors; Brain Neoplasms; Cell Line, Tum | 2017 |
Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo.
Topics: Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Cell-Penetrating Peptides; Gene Pr | 2017 |
Three weeks release BCNU loaded hydrophilic-PLGA microspheres for interstitial chemotherapy: Development and activity against human glioblastoma cells.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Survival; Drug Carriers; Gliobl | 2008 |
Cerebral metabolism during air transport of patients after surgery for malignant glioma.
Topics: Air Ambulances; Brain; Brain Neoplasms; Glioma; Glucose; Glutamic Acid; Glycerol; Humans; Lactic Aci | 2008 |
Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM.
Topics: Adult; Aged; Aspartic Acid; Brain Mapping; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2009 |
Growth inhibition against intracranial C6 glioma cells by stereotactic delivery of BCNU by controlled release from poly(D,L-lactic acid) nanoparticles.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line, Tumor; Glioma; Lactic Acid; Male; Nanoparticles; Po | 2009 |
Local delivery of poly lactic-co-glycolic acid microspheres containing imatinib mesylate inhibits intracranial xenograft glioma growth.
Topics: Animals; Benzamides; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Glioma; Humans; Imatinib Mesy | 2009 |
Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Cell Division; Cell Line, Tu | 2009 |
Peripheral benzodiazepine receptor ligand-PLGA polymer conjugates potentially useful as delivery systems of apoptotic agents.
Topics: Acetamides; Animals; Antineoplastic Agents; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic | 2009 |
Redox dependence and compartmentation of [13C]pyruvate in the brain of deuterated rats bearing implanted C6 gliomas.
Topics: Animals; Astrocytes; Brain Chemistry; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Cerebral C | 2009 |
Magnetic resonance spectroscopic imaging associated with analysis of fluid in cystic brain tumors.
Topics: Brain Neoplasms; Cyst Fluid; Cysts; Humans; Lactic Acid; Magnetic Resonance Spectroscopy | 2010 |
Hydrogel matrix entrapping PLGA-paclitaxel microspheres: drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Brain Neoplasms; Calorimetry, Differential Sc | 2009 |
(1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques.
Topics: Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Contrast Media; Creatine; Echo-Planar | 2009 |
Designing bioresorbable polyester matrices for controlled doxorubicin release in glioma therapy.
Topics: Animals; Antibiotics, Antineoplastic; Brain Neoplasms; Cerebrospinal Fluid; Chemistry, Pharmaceutica | 2009 |
Differential diagnosis between radiation necrosis and glioma progression using sequential proton magnetic resonance spectroscopy and methionine positron emission tomography.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Neoplasms; Carbon Radioisotopes; Choline; Diagnosi | 2009 |
Magnetic resonance spectroscopic evaluation of brain tissue metabolism after irradiation for pediatric brain tumors in long-term survivors: a report of two cases.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Humans; Lactic Acid; Ma | 2010 |
Temozolomide/PLGA microparticles: a new protocol for treatment of glioma in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Dacarbazine; Glioma; In Situ Nick-End La | 2011 |
Development of transferrin functionalized poly(ethylene glycol)/poly(lactic acid) amphiphilic block copolymeric micelles as a potential delivery system targeting brain glioma.
Topics: Brain Neoplasms; Glioma; Humans; Lactic Acid; Micelles; Polyethylene Glycols; Transferrin | 2010 |
Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients.
Topics: Adult; Biomarkers, Tumor; Brain Chemistry; Brain Neoplasms; Echo-Planar Imaging; Female; Glioma; Hum | 2011 |
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors.
Topics: Animals; Brain; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Membrane Permeability; | 2010 |
Temozolomide/PLGA microparticles plus vatalanib inhibits tumor growth and angiogenesis in an orthotopic glioma model.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Treatment of rat brain tumors using sustained-release of camptothecin from poly(lactic-co-glycolic acid) microspheres in a thermoreversible hydrogel.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Delayed-Action Prep | 2010 |
A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system.
Topics: Adult; Blood-Brain Barrier; Brain Neoplasms; Cells, Cultured; Central Nervous System; Cerebrovascula | 2011 |
Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; B | 2011 |
Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells.
Topics: Antibiotics, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Membrane Permeability; Cell Pro | 2011 |
Mathematical modeling of energy metabolism and hemodynamics of WHO grade II gliomas using in vivo MR data.
Topics: Adolescent; Adult; Aged; Algorithms; Brain Neoplasms; Cerebrovascular Circulation; Child; Choline; F | 2011 |
Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1- 13C]pyruvate and 13C magnetic resonance spectroscopic imaging.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Contrast Media; Glioma; Lactic Acid; Ma | 2011 |
The spatial organization of proton and lactate transport in a rat brain tumor.
Topics: Animals; Biological Transport; Brain Neoplasms; Cells, Cultured; Glioma; Ion Transport; Lactic Acid; | 2011 |
Metabolic assessment of monofocal acute inflammatory demyelination using MR spectroscopy and (11)C-methionine-, (11)C-choline-, and (18)F-fluorodeoxyglucose-PET.
Topics: Brain Neoplasms; Carbon Radioisotopes; Choline; Creatine; Demyelinating Diseases; Diagnosis, Differe | 2011 |
[2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.
Topics: 3-Hydroxybutyric Acid; Animals; Aspartic Acid; Astrocytes; Brain Neoplasms; Citric Acid Cycle; Diet, | 2011 |
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.
Topics: Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Carbon Isotopes; Cell Line, Tumor; Daca | 2011 |
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Topics: Animals; Antineoplastic Agents; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Coumaric Ac | 2011 |
Nanotextured substrates with immobilized aptamers for cancer cell isolation and cytology.
Topics: Aptamers, Nucleotide; Brain Neoplasms; Cell Separation; Cells, Cultured; Cytodiagnosis; Cytological | 2012 |
RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival.
Topics: Adenosine Triphosphate; Brain Neoplasms; Cell Death; Cell Survival; Gene Expression Regulation, Neop | 2012 |
Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells.
Topics: Acetone; Animals; Antineoplastic Agents; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Cell Movement | 2011 |
Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells.
Topics: Adsorption; Animals; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Caveo | 2012 |
Improvement of survival in C6 rat glioma model by a sustained drug release from localized PLGA microspheres in a thermoreversible hydrogel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Camptothecin; Cell Line, Tumor; | 2012 |
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages.
Topics: Animals; Biological Transport; Brain Neoplasms; Cell Line, Tumor; Chemical Precipitation; Chemistry, | 2012 |
Combination therapy of surgical tumor resection with implantation of a hydrogel containing camptothecin-loaded poly(lactic-co-glycolic acid) microspheres in a C6 rat glioma model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Cell Line, Tumor; Combine | 2012 |
Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Biological Transport; Brain Neoplasms; Cell Line, Tumor; | 2012 |
Repeatability of edited lactate and other metabolites in astrocytoma at 3T.
Topics: Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Female; Humans; Lactic Acid; Magnetic Resonance Spe | 2012 |
Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Brain Neoplasms; Cell Cycle Che | 2013 |
Smart multifunctional core-shell nanospheres with drug and gene co-loaded for enhancing the therapeutic effect in a rat intracranial tumor model.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Carriers; Dru | 2012 |
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
Topics: Adenosine Triphosphate; Animals; Autophagy; Blotting, Western; Brain; Brain Neoplasms; Cell Prolifer | 2012 |
Etoposide encapsulation in surface-modified poly(lactide-co-glycolide) nanoparticles strongly enhances glioma antitumor efficiency.
Topics: Animals; Antineoplastic Agents, Phytogenic; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; | 2013 |
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.
Topics: Animals; Brain Neoplasms; Carrier Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Enzym | 2012 |
Sustainable release of carmustine from biodegradable poly[((D,L))-lactide-co-glycolide] nanofibrous membranes in the cerebral cavity: in vitro and in vivo studies.
Topics: Absorbable Implants; Animals; Antineoplastic Agents, Alkylating; Biocompatible Materials; Biological | 2013 |
On a minimal model for hemodynamics and metabolism of lactate: application to low grade glioma and therapeutic strategies.
Topics: Brain Neoplasms; Glioma; Hemodynamics; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Models, | 2013 |
Analysis of fluid in craniopharyngioma-related cysts in children: proteins, lactate and pH.
Topics: Adolescent; Albumins; Blood-Brain Barrier; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; | 2002 |
Brain abscess and glioblastoma identified by combined proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging--two case reports.
Topics: Acetates; Adult; Amino Acids; Aspartic Acid; Brain Abscess; Brain Neoplasms; Diagnosis, Differential | 2002 |
Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis.
Topics: Adult; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glioma; Humans; Lactic Acid; Lip | 2002 |
A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier.
Topics: Algorithms; Animals; Aorta; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Capillaries; Cattle; C | 2002 |
In regard to Tarnawski et al., IJROBP 2002;52:1271-1276.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Female; Glioma; Humans; Hydrogen; Lactic Acid; Luminescen | 2002 |
Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy.
Topics: Alanine; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Glioblastoma; Humans; Inosi | 2003 |
Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors.
Topics: Adolescent; Adult; Aged; Alanine; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creat | 2003 |
Computer simulation of the delivery of etanidazole to brain tumor from PLGA wafers: comparison between linear and double burst release systems.
Topics: Animals; Brain Neoplasms; Computer Simulation; Drug Delivery Systems; Drug Implants; Etanidazole; Hu | 2003 |
Modeling of pathophysiological coupling between brain electrical activation, energy metabolism and hemodynamics: insights for the interpretation of intracerebral tumor imaging.
Topics: Adenosine Triphosphate; Blood-Brain Barrier; Brain Neoplasms; Cerebrovascular Circulation; Energy Me | 2002 |
1H-MR spectroscopy of normal brain tissue before and after postoperative radiotherapy because of primary brain tumors.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Combined Modality Therapy; Female; Humans; | 2003 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain | 2003 |
A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Cerebrospinal Fluid; Choline; Creatine; Disc | 2003 |
Evaluation of the response of metastatic brain tumors to stereotactic radiosurgery by proton magnetic resonance spectroscopy, 201TlCl single-photon emission computerized tomography, and gadolinium-enhanced magnetic resonance imaging.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Neoplasms; Choline; Contrast Media; Fema | 2004 |
Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Mapping; Brain Neoplasms; Choline; Cohor | 2004 |
Gliotoxins disrupt alanine metabolism and glutathione production in C6 glioma cells: a 13C NMR spectroscopic study.
Topics: Alanine; Alanine Transaminase; Brain Neoplasms; Cell Line, Tumor; Dicarboxylic Acids; Enzyme Inhibit | 2004 |
Multi-spin-echo J-resolved spectroscopic imaging without water suppression: application to a rat glioma at 7 T.
Topics: Algorithms; Animals; Biomarkers, Tumor; Brain Neoplasms; Diagnosis, Computer-Assisted; Female; Gliom | 2004 |
Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors.
Topics: Aspartic Acid; Biomarkers, Tumor; Brain Neoplasms; Child; Child, Preschool; Choline; Creatine; Femal | 2004 |
Proton MRS of the peritumoral brain.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Edema; Brain Neoplasms; Epilepsy; Female; Huma | 2005 |
Clinicopathological examination of glioma by proton magnetic resonance spectroscopy background.
Topics: Adult; Aspartic Acid; Brain Neoplasms; Choline; Female; Glioma; Humans; Lactic Acid; Magnetic Resona | 2004 |
Early metabolic changes in metastatic brain tumors after Gamma Knife radiosurgery: 1H-MRS study.
Topics: Aged; Aspartic Acid; Brain Neoplasms; Creatine; Female; Glycerylphosphorylcholine; Humans; Lactic Ac | 2004 |
Continuous delivery of endogenous inhibitors from poly(lactic-co-glycolic acid) polymeric microspheres inhibits glioma tumor growth.
Topics: Animals; Biocompatible Materials; Brain Neoplasms; Cattle; Coagulants; Drug Delivery Systems; Endoth | 2005 |
Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo.
Topics: Blood Volume; Brain Neoplasms; Glioma; Humans; Lactic Acid; Lipids; Magnetic Resonance Spectroscopy; | 2005 |
MRS of oligodendroglial tumors: correlation with histopathology and genetic subtypes.
Topics: Adult; Aged; Allelic Imbalance; Astrocytoma; Brain Neoplasms; Choline; Chromosomes, Human, Pair 1; C | 2005 |
Non-invasive quantification of lactate by proton MR spectroscopy and its clinical applications.
Topics: Adult; Aged; Body Water; Brain Infarction; Brain Neoplasms; Female; Glioma; Humans; Lactic Acid; Lym | 2005 |
Enhancement of the stability of BCNU using self-emulsifying drug delivery systems (SEDDS) and in vitro antitumor activity of self-emulsified BCNU-loaded PLGA wafer.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Survival; Dru | 2005 |
Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemistry, Phar | 2005 |
Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy.
Topics: Aged; Algorithms; Brain Chemistry; Brain Neoplasms; Female; Glioblastoma; Humans; Lactic Acid; Lipid | 2005 |
Multisection 1H magnetic resonance spectroscopic imaging assessment of glioma response to chemotherapy.
Topics: Adult; Antineoplastic Agents; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Disease-Free Surviv | 2006 |
Independent component analysis to proton spectroscopic imaging data of human brain tumours.
Topics: Algorithms; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cell Proliferation; Choline; Creatine; Glio | 2005 |
Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Drug Carriers; Drug Compounding; Drug Implants; | 2006 |
Multiparametric 3T MR approach to the assessment of cerebral gliomas: tumor extent and malignancy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Contrast Media; Creatine; Diffusio | 2006 |
Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chemical Phenom | 2006 |
Proton magnetic resonance spectroscopy (MRS) of metastatic brain tumors: variations of metabolic profile.
Topics: Aged; Algorithms; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Evalua | 2006 |
Evaluation of particulate systems supporting tumor cell fractions in a preventive vaccination against intracranial rat glioma.
Topics: Animals; Antigens, Neoplasm; Biocompatible Materials; Brain Neoplasms; Cancer Vaccines; Cell Fractio | 2006 |
Distinction between recurrent glioma and radiation injury using magnetic resonance spectroscopy in combination with diffusion-weighted imaging.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Diagnosis, Differential; Diffusion Magn | 2007 |
Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Demyelinating Diseases; | 2007 |
Differential effects of PPARgamma agonists on the metabolic properties of gliomas and astrocytes.
Topics: Animals; Antineoplastic Agents; Astrocytes; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Surv | 2007 |
Poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles prepared by high pressure homogenization for paclitaxel chemotherapy.
Topics: Antineoplastic Agents, Phytogenic; Brain Neoplasms; Calorimetry, Differential Scanning; Cell Surviva | 2007 |
Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma.
Topics: Adult; Aged; Brain Neoplasms; Creatine; Female; Glioma; Humans; Lactic Acid; Magnetic Resonance Imag | 2007 |
Giant infantile gliosarcoma: magnetic resonance imaging findings.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Child, Preschool; Choline; Creatinine; Female; Gliosarcoma; H | 2008 |
Central nervous system lymphoma characterization by diffusion-weighted imaging and MR spectroscopy.
Topics: Adult; Aged; Aspartic Acid; Biopsy; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differenti | 2008 |
Characterization of intracranial mass lesions with in vivo proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Diseases; Brain Neoplasms; Child; Choline; Crea | 1995 |
Preparation and characterization of 5-fluorouracil-loaded microparticles as biodegradable anticancer drug carriers.
Topics: Biocompatible Materials; Biodegradation, Environmental; Brain Neoplasms; Delayed-Action Preparations | 1995 |
Interstitial chemotherapy with biodegradable ACNU pellet for glioblastoma.
Topics: Adult; Aged; Animals; Biodegradation, Environmental; Brain Neoplasms; Drug Implants; Female; Gliobla | 1994 |
Incorporation of lactate measurement in multi-spin-echo proton spectroscopic imaging.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Humans; Image Processing, | 1995 |
[Clinical suitability of brain tumor patients for single voxel protein MR spectroscopy].
Topics: Aspartic Acid; Brain Neoplasms; Cell Division; Choline; Creatine; Energy Metabolism; Humans; Lactate | 1994 |
Metabolic loss of deuterium from isotopically labeled glucose.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Cerebral Cortex; Deuterium; Gas Chromatography-Mass Spect | 1994 |
Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy.
Topics: Aspartic Acid; Brain Neoplasms; Choline; Glioma; Humans; Lactates; Lactic Acid; Magnetic Resonance I | 1993 |
Quantitative proton spectroscopy and histology of a canine brain tumor model.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Dogs; Glioma; Lactates; Lactic Acid; Mag | 1993 |
Phased spectroscopic images: application to the characterization of the 1H 1.3-ppm resonance in intracerebral tumors in the rat.
Topics: Animals; Brain; Brain Neoplasms; Fourier Analysis; Glioma; Lactates; Lactic Acid; Magnetic Resonance | 1993 |
[Spectroscopic imaging of the brain. Examination technique and clinical applications].
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Cerebral Infarction; Choline; Creatine; Energy M | 1995 |
Imaging brain tumors -- beyond three dimensions.
Topics: Aged; Alanine; Brain Neoplasms; Choline; Female; Glioblastoma; Humans; Lactates; Lactic Acid; Magnet | 1996 |
Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy.
Topics: Adult; Alanine; Aspartic Acid; Astrocytoma; Biomarkers; Brain; Brain Neoplasms; Choline; Creatine; D | 1996 |
Noninvasive evaluation of malignancy of brain tumors with proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Femal | 1996 |
Intracranial tumors in children: small single-voxel proton MR spectroscopy using short- and long-echo sequences.
Topics: Adolescent; Aspartic Acid; Brain Neoplasms; Child; Child, Preschool; Choline; Creatinine; Female; Gl | 1996 |
Hydrogen magnetic resonance spectroscopy follow-up after radiation therapy of human brain cancer. Unexpected inverse correlation between the changes in tumor choline level and post-gadolinium magnetic resonance imaging contrast.
Topics: Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Energy Metabolism; Follow-Up Studies; Four | 1995 |
Central neurogenic hyperventilation in an awake patient with a pontine glioma.
Topics: Astrocytoma; Brain Neoplasms; Cerebrospinal Fluid; Humans; Hydrogen-Ion Concentration; Hyperventilat | 1996 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
Relationships among lactate concentration, blood flow and histopathologic profiles in rat C6 glioma.
Topics: Animals; Brain Neoplasms; Glioma; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Neoplasm Trans | 1996 |
Effect of 6-aminonicotinamide on metabolism of astrocytes and C6-glioma cells.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain Neoplasms; | 1997 |
Alterations of lactate (+lipid) concentration in brain tumors with in vivo hydrogen magnetic resonance spectroscopy during radiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Brain Chemistry; Brain Neoplasms; Female; Glioblastoma; Humans; Lact | 1997 |
Intralesionally implanted cisplatin cures primary brain tumor in rats.
Topics: Animals; Brain Neoplasms; Cisplatin; Delayed-Action Preparations; Drug Implants; Gliosarcoma; Lactic | 1997 |
Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study.
Topics: Adult; Aged; Aspartic Acid; Biomarkers, Tumor; Biopsy; Brain Neoplasms; Cell Transformation, Neoplas | 1997 |
Transient metabolic changes observed with proton MR spectroscopy in normal human brain after radiation therapy.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactic Acid; Magnet | 1998 |
Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Gliosarcoma; Hydrogen-Ion Concentration; Indazoles; | 1998 |
In vivo single-voxel proton MR spectroscopy in intracranial cystic masses.
Topics: Adult; Amino Acids; Brain Abscess; Brain Diseases; Brain Neoplasms; Cysticercosis; Cysts; Female; Ga | 1998 |
Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site.
Topics: Adolescent; Adult; Antineoplastic Agents; Aspartic Acid; Brain; Brain Neoplasms; Child; Child, Presc | 1998 |
In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1.5 T using PRESS excitation with applications to the study of brain and head and neck tumors.
Topics: Aspartic Acid; Brain Chemistry; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactic Acid; Lip | 1998 |
Modulation of VEGF production by pH and glucose in retinal Müller cells.
Topics: Animals; Brain Neoplasms; Cell Hypoxia; Cells, Cultured; Endothelial Growth Factors; Enzyme-Linked I | 1998 |
Lactate turnover in rat glioma measured by in vivo nuclear magnetic resonance spectroscopy.
Topics: Animals; Brain Neoplasms; Carbon Isotopes; Glioma; Glucose; Glutamic Acid; Glycolysis; Lactic Acid; | 1998 |
Classification of biopsy-confirmed brain tumors using single-voxel MR spectroscopy.
Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Astrocytoma; Biopsy; Body Water; Brain Neoplasms; | 1999 |
Comparison of MR spectroscopy and MR imaging with contrast agent in children with cerebral astrocytomas.
Topics: Adolescent; Astrocytoma; Brain; Brain Neoplasms; Child; Child, Preschool; Contrast Media; Gadolinium | 1999 |
Comparison of different methods of intracerebral administration of radioiododeoxyuridine for glioma therapy using a rat model.
Topics: Animals; Brain Neoplasms; Coated Materials, Biocompatible; Drug Delivery Systems; Female; Glioma; Id | 2000 |
Effect of voxel position on single-voxel MR spectroscopy findings.
Topics: Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Choline; Creatine; Diagnosis, Differential; Glio | 2000 |
[Effect of normobaric hyperoxia on parameters of brain metabolism].
Topics: Adult; Anesthesia, Intravenous; Blood Gas Analysis; Brain; Brain Neoplasms; Craniotomy; Energy Metab | 2000 |
Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study.
Topics: Amino Acids; Animals; Ascorbic Acid; Brain Chemistry; Brain Neoplasms; Extracellular Space; Female; | 2000 |
Quantitative proton magnetic resonance spectroscopy of focal brain lesions.
Topics: Adolescent; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Abscess; Brain Diseases; Brain Neoplasms; | 2000 |
In vivo study of tumor metabolism: an application of new multi-probe microdialysis system in the striatum of freely moving rats grafted with C6 cells.
Topics: Animals; Brain Neoplasms; Corpus Striatum; Glioma; Glucose; Lactic Acid; Male; Microdialysis; Pyruvi | 2000 |
Serial proton MR spectroscopic imaging of recurrent malignant gliomas after gamma knife radiosurgery.
Topics: Adult; Aspartic Acid; Brain; Brain Neoplasms; Choline; Energy Metabolism; Female; Follow-Up Studies; | 2001 |
Proton magnetic resonance chemical shift imaging (1H CSI)-directed stereotactic biopsy.
Topics: Adult; Aspartic Acid; Biopsy, Needle; Brain; Brain Neoplasms; Creatine; Diagnosis, Differential; Ene | 2001 |
An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Biopsy; Brain; Brain Mapping; Brain Neop | 2001 |
High glycolytic activity in rat glioma demonstrated in vivo by correlation peak 1H magnetic resonance imaging.
Topics: Alanine; Animals; Aspartic Acid; Brain Neoplasms; Choline; Creatine; Ethanolamines; Female; Glioma; | 2001 |
Differentiation between high-grade glioma and metastatic brain tumor using single-voxel proton MR spectroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspartic Acid; Astrocytoma; Brain; Brain Neoplasms; Chil | 2001 |
Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites.
Topics: Animals; Aspartic Acid; Brain Neoplasms; Buffers; Choline; Contrast Media; Creatine; Extracellular S | 2001 |
Effect of exogenous lactate on rat glioma metabolism.
Topics: Animals; Blood Glucose; Brain; Brain Neoplasms; Carbon; Carbon Radioisotopes; Citric Acid Cycle; Ene | 2001 |
Improved analysis of 1H-MR spectra in the presence of mobile lipids.
Topics: Alanine; Artifacts; Brain; Brain Diseases; Brain Neoplasms; Glioblastoma; Glioma; Humans; Image Enha | 2001 |
Correlation between magnetic resonance spectroscopy imaging and image-guided biopsies: semiquantitative and qualitative histopathological analyses of patients with untreated glioma.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Dominance, Cerebr | 2001 |
Intraoperative values of S-100 protein, myelin basic protein, lactate, and albumin in the CSF and serum of neurosurgical patients.
Topics: Adolescent; Adult; Aged; Albumins; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Infant; | 2001 |
Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor.
Topics: Adult; Aspartic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Creatine; Diffusion; Fem | 2002 |
Anti-cancer drug diffusion within living rat brain tissue: an experimental study using [3H](6)-5-fluorouracil-loaded PLGA microspheres.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Brain; Brain Neoplasms; Contrast Media; Dif | 2002 |
Mapping of brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Neoplasms; Choline; Creatine; Female; Glucose; | 1992 |
Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques.
Topics: Acute Disease; Adult; Aspartic Acid; Biopsy; Brain Chemistry; Brain Neoplasms; Choline; Creatine; De | 1992 |
In vivo imaging of glucose consumption and lactate concentration in human gliomas.
Topics: Adult; Brain Neoplasms; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glioma; Glucose; Glycolysis; H | 1992 |
Spatially localized in vivo 1H magnetic resonance spectroscopy of an intracerebral rat glioma.
Topics: Animals; Aspartic Acid; Brain; Brain Neoplasms; Creatine; Female; Glioma; Hydrogen; Lactates; Lactic | 1992 |
In vivo 1H-spectroscopy of human intracranial tumors at 1.5 tesla. Preliminary experience at a clinical installation.
Topics: Adult; Aged; Aspartic Acid; Astrocytoma; Brain Neoplasms; Choline; Creatine; Female; Humans; Lactate | 1991 |
A pitfall associated with lactate detection using stimulated-echo proton spectroscopy.
Topics: Alanine; Brain Chemistry; Brain Neoplasms; Fourier Analysis; Humans; Hydrogen; Lactates; Lactic Acid | 1991 |
The role of transmembrane pH gradients in the lactic acid induced swelling of astrocytes.
Topics: Alanine; Astrocytes; Brain Neoplasms; Cell Membrane; Dimethadione; Glioma; Humans; Hydrogen-Ion Conc | 1990 |
Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors.
Topics: Adult; Aspartic Acid; Brain Chemistry; Brain Diseases; Brain Neoplasms; Choline; Creatinine; Cysts; | 1989 |
Lactate and pH in the brain: association and dissociation in different pathophysiological states.
Topics: Animals; Brain; Brain Ischemia; Brain Neoplasms; Hydrogen-Ion Concentration; Ischemic Attack, Transi | 1987 |
Regional metabolism of experimental brain tumors.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Cell Line; Glucose; Glycolysis; Hydrogen-Ion Conce | 1986 |
Regional quantitative determination of lactate in brain sections. A bioluminescent approach.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Brain Neoplasms; Freeze Drying; Gerbillinae; Glucos | 1985 |