lactic acid has been researched along with Brain Ischemia in 348 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the protective effects of ginkgo diterpene lactone meglumine injection (GDLMI) on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats, and explore its possible mechanism." | 7.85 | [Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats]. ( Cao, L; Cao, ZY; Hu, HF; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ, 2017) |
| "It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region." | 7.79 | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. ( Du, D; Jiang, CL; Li, MH; Liu, MF; Meng, Q; Peng, HS; Sun, SL; Tao, HQ; Wang, YM; Yang, HC; Yang, LZ; Ye, W; Yu, H; Zhu, DL, 2013) |
| "To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 7.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 7.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 7.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "In the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia in rabbits was studied." | 7.72 | Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia. ( Ak, A; Bariskaner, H; Dogan, N; Gurbilek, M; Ustun, ME; Yosunkaya, A, 2003) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 7.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| "For the human brain, there are no data available concerning the significance of adenosine and its metabolites as biochemical indicators of cerebral ischemia." | 7.70 | Adenosine: a sensitive indicator of cerebral ischemia during carotid endarterectomy. ( Bardenheuer, HJ; Eckstein, HH; Martin, E; Michel, A; Weigand, MA, 1999) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 7.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 7.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "The effect of nitrendipine, an antihypertensive calcium antagonist, on the impairment of cerebral blood flow and EEG observed after 10-min complete cerebral ischemia in anesthetized rabbits was compared with those of nicardipine." | 7.68 | Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits. ( Aihara, K; Inui, J, 1991) |
| "The concentrations of acetylcholine (Ach) and choline in various brain regions of rats with and without cerebral ischemia and the effects of 6-(10-hydroxy-decyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the levels of these parameters were investigated." | 7.67 | Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1984) |
| "Studies were performed on 16 cats to evaluate the potential protective effects of Gallopamil on brain ischemia." | 7.67 | 31P and 1H NMR spectroscopy to study the effects of gallopamil on brain ischemia. ( Chance, B; Kovach, AG; Leigh, JS; Ligeti, L; Osbakken, MD; Subramanian, HV, 1987) |
| " In six dogs the effects of etomidate (5 mg X kg-1) on the rates of adenosine triphosphate (ATP) and phosphocreatine (PCr) depletion and lactate accumulation during 9 min of oligemic hypotension to 31 mmHg were compared with six untreated dogs." | 7.67 | Preservation of cerebral metabolites by etomidate during incomplete cerebral ischemia in dogs. ( Milde, JH; Milde, LN, 1986) |
| "The experimental study presented was undertaken to evaluate the role of thromboxane A2 contributing to aggravating cerebral ischemia, and to examine the effect of a thromboxane A2 synthetase inhibitor, trapidil on cerebral ischemia." | 7.67 | [Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia]. ( Katayama, Y; Memezawa, H; Minamisawa, H; Shimizu, J; Sugimoto, S; Suzuki, S; Terashi, A, 1986) |
| "The effects of antiedematous agent with intravenous 10% glycerol on cerebral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR)." | 7.67 | Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats. ( Fujishima, M; Ibayashi, S; Ishitsuka, T; Sadoshima, S; Shiokawa, O; Yoshida, F, 1986) |
| "The protective effect of vinpocetine on experimental brain ischemia was studied in stroke-prone spontaneously hypertensive rats (SHRSP) with bilateral carotid artery occlusion (BCAO) and in Wistar-Kyoto rats (WKY) subjected to BCAO and hemorrhage (1% of body weight)." | 7.66 | [Protective effect of vinpocetine on experimental brain ischemia]. ( Hamajo, K; Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1982) |
| "Under global cerebral ischemia, the effect of different brain temperature on cerebral ischemic injury was studied." | 5.40 | Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures. ( Li, L; Mei, YW; Murong, SX; Sun, SG; Tong, ET; Xu, GY; Zhang, H; Zhang, JJ, 2014) |
| "Mice pathological model of acute cerebral ischemia was established." | 5.34 | [Effect of salvianolic acid B on brain energy metabolism and hydrocephalus of cerebral ischemia in mice at different time]. ( Huang, QF; Jiang, YF; Liu, ZQ; Ren, LW; Wang, Q; Wang, WR; Wang, XM; Zhang, Y, 2007) |
| "Treatment with buflomedil attenuated ischemia-induced histological loss and damage of CA1 pyramidal cells." | 5.33 | Protective effect of buflomedil in a rat model of moderate cerebral ischemia. ( Briguglio, FS; De Pasquale, A; Galluzzo, M; Mondello, MR; Raneri, E; Saija, A; Trombetta, D, 2005) |
| "To validate this assay, a focal cerebral ischemia was produced by occlusion of one common carotid artery for 60 min and then reperfusion for additional 3 h in awake gerbils." | 5.31 | Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. ( Chen, SH; Cheng, FC; Lee, CW; Tsai, TH; Yan, DY; Yang, LL, 2000) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 5.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 5.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| "Cerebral ischemia marker (S-100B, NSE, lactate) patterns were as expected during CPB; however, there were no differences between the groups, which led us to believe that during CABG surgery dexmedetomidine has no neuroprotective effects." | 5.12 | Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?--A preliminary study. ( Aldemir, D; Dönmez, A; Sezgin, A; Sulemanji, DS; Türkoglu, S, 2007) |
| " The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected." | 5.09 | Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000) |
| "Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population." | 4.12 | Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022) |
| "To investigate the protective effects of ginkgo diterpene lactone meglumine injection (GDLMI) on cerebral focal ischemia reperfusion injury induced by middle cerebral artery occlusion (MCAO) in rats, and explore its possible mechanism." | 3.85 | [Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats]. ( Cao, L; Cao, ZY; Hu, HF; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ, 2017) |
| " Here we sought to identify whether the enhanced lactic acidosis and increased expression of monocarboxylate transporters (MCTs) observed after stroke might be attenuated by single and/or combined EtOH and NBO therapies." | 3.81 | Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. ( Brogan, D; Cai, L; Ding, Y; Du, H; Geng, X; Ji, X; Kwiecien, TD; Peng, C; Rafols, JA; Rastogi, R; Singh, S; Sy, CA, 2015) |
| "Neuroprotective properties of the new derivative of glutamic and apovincaminic acids, ethyl -(3-alpha,16-alpha)-eburnamenin-14-carbopxylate of 2-aminopentadionic acid (LHT 1-02) were studied on a model of acute brain ischemia in cats." | 3.80 | [Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period]. ( Makarova, LM; Mirzoian, RS; Pogorelyĭ, VE; Prikhod'ko, MA; Skachilova, SIa, 2014) |
| "56 g/kg) could upgrade glucose (Glu), total amino acids (T-AA), ATP, Na(+)-K(+) -ATPase, superoxide dismutase (SOD) and catalase (CAT) of brain tissue and degrade lactic acid (LD), malondialdehyde (MDA) and water content of brain tissue in cerebral ischemia rat (P < 0." | 3.80 | [Effect of JTS caps. treating cerebral ischemia on metabolism and antioxidant system in cerebral ischemia rat]. ( Liu, YQ; Wang, RQ; Wang, ZW; Yan, CL; Zhao, B, 2014) |
| "It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region." | 3.79 | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. ( Du, D; Jiang, CL; Li, MH; Liu, MF; Meng, Q; Peng, HS; Sun, SL; Tao, HQ; Wang, YM; Yang, HC; Yang, LZ; Ye, W; Yu, H; Zhu, DL, 2013) |
| "To study the protective effects of lycopene (LP) on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia and oxidative stress in rats." | 3.76 | [The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats]. ( Mai, JY; Shen, H; Shen, XN; Wang, RZ; Wei, Y; Wu, M, 2010) |
| " Brain tissue was collected following 20 minute cerebral ischemia and 240 minute reperfusion, and used to measure the levels of malondialdehyde (MDA), lactate, water content and the amounts of electrolytes, such as sodium (Na(+)), potassium (K(+)) and calcium (Ca(++))." | 3.75 | Initiation time of post-ischemic hypothermia on the therapeutic effect in cerebral ischemic injury. ( Mei, Y; Sun, S; Tong, E; Zhang, H; Zhang, J; Zhou, M, 2009) |
| "The goals of this work were first to assess whether the lactic acidosis observed in vivo in ischemia may by itself explain the inhibition of protein synthesis described in the literature and second to study the factors controlling the initiation of protein synthesis under lactic acid stress." | 3.74 | Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress. ( Barrier, L; Fauconneau, B; Guillard, O; Ingrand, S; Page, G; Pain, S; Piriou, A; Rioux-Bilan, A; Vantelon, N, 2007) |
| "Using the middle cerebral artery occlusion model (MCAO) in rats and cerebral ischemia-reperfusion models in gerbils and mice, we investigated the influence of pueraria compound on the brain water content and the infarct size, the cerebral apoplexy exponent, the contents of lactic acid (LA) and lipid peroxide (LPO), the activities of lactic dehydrogenase (LDH), glutathione peroxidase (GPx) and Na+ -K+ -ATPase." | 3.73 | [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. ( Cao, CY; Cui, HF; Du, GY; Wang, XR; Zhang, CY; Zhao, Y, 2005) |
| "The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques." | 3.73 | The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia. ( Jellish, WS; Kindel, G; Murdoch, J; White, FA; Zhang, X, 2005) |
| "We assess the effects of ipsapirone (a 5-HT1A receptor agonist), ketanserin (a 5-HT2A receptor antagonist), (-)-pindolol (a 5-HT1A receptor antagonist), and DOI (a 5-HT2A receptor agonist) on heatstroke in a rat model." | 3.73 | Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. ( Chang, CP; Chen, SH; Lin, MT, 2005) |
| "In the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia in rabbits was studied." | 3.72 | Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia. ( Ak, A; Bariskaner, H; Dogan, N; Gurbilek, M; Ustun, ME; Yosunkaya, A, 2003) |
| "We here reported the clinical course and therapeutic details of a 16-year-old girl with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had had five stroke-like episodes (two episodes were clinically mild, while the three subsequent episodes were severe)." | 3.72 | Beneficial effect of L-arginine for stroke-like episode in MELAS. ( Kubota, M; Momoi-Yoshida, M; Mori, M; Sakakihara, Y; Yamagata, T, 2004) |
| " In this study we evaluated the effect of global brain ischemia on brain metabolic parameters in normal and diabetic rats treated with a dihydropyridine calcium antagonist, felodipine." | 3.72 | The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers. ( Dunbar, JC; Levy, J; Zhu, Z, 2004) |
| " To test the role of lactate as an aerobic energy substrate postischemia in vivo, we employed the cardiac-arrest-induced transient global cerebral ischemia (TGI) rat model and the monocarboxylate transporter inhibitor alpha-cyano-4-hydroxycinnamate (4-CIN)." | 3.71 | Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia. ( Miller, JJ; Payne, RS; Rigor, BM; Schurr, A; Tseng, MT, 2001) |
| "Numerous studies using adult animal models suggest that dichloroacetate (DCA) may have neuroprotective properties by virtue of its ability to increase rates of metabolism and, therefore, clearance of brain lactic acidosis, which may accumulate during cerebral ischemia." | 3.70 | Age-related differences in the effect of dichloroacetate on postischemic lactate and acid clearance measured in vivo using magnetic resonance spectroscopy and microdialysis. ( Corbett, R; Garcia, D; Gee, J; Laptook, A; Silmon, S; Tollefsbol, G, 1998) |
| " immature brain, and may reflect differences in the extent or duration of cerebral lactic acidosis." | 3.70 | Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis. ( Corbett, R; Garcia, D; Kim, B; Laptook, A; Silmon, S; Tollefsbol, G, 1999) |
| "For the human brain, there are no data available concerning the significance of adenosine and its metabolites as biochemical indicators of cerebral ischemia." | 3.70 | Adenosine: a sensitive indicator of cerebral ischemia during carotid endarterectomy. ( Bardenheuer, HJ; Eckstein, HH; Martin, E; Michel, A; Weigand, MA, 1999) |
| "Bedside intracerebral microdialysis monitoring of patients with subarachnoid hemorrhage and signs of delayed ischemia revealed dramatic changes in extracellular concentrations of glucose, lactate, and glycerol that could be directly correlated to the clinical status of the patients." | 3.70 | Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration. ( Brandt, L; Nilsson, OG; Säveland, H; Ungerstedt, U, 1999) |
| "The apparent diffusion coefficient (ADC) of choline-containing compounds (Cho), creatine and phosphocreatine (Cre), N-acetyl-aspartate (NAA), lactate, and water was measured in normal rat brain, and in the ischemic and contralateral region of rat brain approximately 3 and 24 h after induction of focal cerebral ischemia." | 3.69 | Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS. ( Dijkhuizen, RM; Nicolay, K; Tulleken, CA; van der Toorn, A, 1996) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 3.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 3.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "The effects of dichloroacetate (DCA) on brain lactate, intracellular pH (pHi), phosphocreatine (PCr), and ATP during 60 min of complete cerebral ischemia and 2 h of reperfusion were investigated in rats by in vivo 1H and 31P magnetic resonance spectroscopy; brain lactate, water content, cations, and amino acids were measured in vitro after reperfusion." | 3.68 | Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats. ( Abiko, H; Chang, LH; Faden, AI; James, TL; Shimizu, H; Swanson, RA; Weinstein, PR, 1992) |
| " Within 5-15 min after the onset of reperfusion, the Lac/NAA peak ratio increased further in all rats; however, only in extremely hyperglycemic rats (serum glucose greater than 960 mg/dl) did the lactic acidosis progress rather than recover later during reperfusion." | 3.68 | Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels. ( Abiko, H; Faden, AI; James, TL; Weinstein, PR; Widmer, H, 1992) |
| "Morphometric quantitation of cerebral hemorrhage and infarction and fluorometric determinations of blood and brain tissue, glucose, glycogen, lactate, adenosine triphosphate, and phosphocreatine from 16 topographic brain sites were carried out." | 3.68 | Hemorrhagic infarct conversion in experimental stroke. ( de Courten-Myers, GM; DeVoe, G; Holm, P; Kleinholz, M; Myers, RE; Schmitt, G; Wagner, KR, 1992) |
| "The effect of nitrendipine, an antihypertensive calcium antagonist, on the impairment of cerebral blood flow and EEG observed after 10-min complete cerebral ischemia in anesthetized rabbits was compared with those of nicardipine." | 3.68 | Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits. ( Aihara, K; Inui, J, 1991) |
| " To address the potential mechanism(s) by which opiate-receptor antagonists may exert their protective actions in cerebral ischemia, metabolic and biochemical changes were measured in brain of rats pretreated with the opiate-receptor antagonist nalmefene or vehicle and subjected to 60 min of global ischemia followed by 2 hr of reperfusion." | 3.68 | Opiate-receptor antagonist improves metabolic recovery and limits neurochemical alterations associated with reperfusion after global brain ischemia in rats. ( Chang, LH; Faden, AI; James, TL; Lemke, M; Shirane, R; Weinstein, PR, 1990) |
| "The concentrations of acetylcholine (Ach) and choline in various brain regions of rats with and without cerebral ischemia and the effects of 6-(10-hydroxy-decyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (idebenone, CV-2619) on the levels of these parameters were investigated." | 3.67 | Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia. ( Kakihana, M; Nagaoka, A; Yamazaki, N, 1984) |
| "Cerebral blood flow (CBF, by laser Doppler flowmetry) and extracellular cortical concentrations (by microdialysis) of adenosine, inosine, xanthine, hypoxanthine, and lactate were measured together with somatosensory evoked potentials (SEP) in chloralose-anaesthetized spontaneously hypertensive rats (SHR) during relative cerebral ischemia induced by hypotensive hemorrhage." | 3.67 | Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites. ( Carlsson, S; Hagberg, H; Sandberg, M; Skarphedinsson, JO; Thorén, P, 1989) |
| " The prior treatment of hypertension was achieved by administration of hydroflumethiazide (120 mg/kg/day) and captopril (15-30 mg/kg/day) orally for 4-6 weeks by mixing in drinking water." | 3.67 | [Effect of long-term prior antihypertensive treatment on cerebral ischemia induced by bilateral common carotid artery ligation in SHRSR]. ( Inamura, K; Katayama, Y; Nagazumi, A; Shimizu, J; Soeda, T; Sugimoto, S; Suzuki, S; Terashi, A, 1986) |
| "Studies were performed on 16 cats to evaluate the potential protective effects of Gallopamil on brain ischemia." | 3.67 | 31P and 1H NMR spectroscopy to study the effects of gallopamil on brain ischemia. ( Chance, B; Kovach, AG; Leigh, JS; Ligeti, L; Osbakken, MD; Subramanian, HV, 1987) |
| " In six dogs the effects of etomidate (5 mg X kg-1) on the rates of adenosine triphosphate (ATP) and phosphocreatine (PCr) depletion and lactate accumulation during 9 min of oligemic hypotension to 31 mmHg were compared with six untreated dogs." | 3.67 | Preservation of cerebral metabolites by etomidate during incomplete cerebral ischemia in dogs. ( Milde, JH; Milde, LN, 1986) |
| "The experimental study presented was undertaken to evaluate the role of thromboxane A2 contributing to aggravating cerebral ischemia, and to examine the effect of a thromboxane A2 synthetase inhibitor, trapidil on cerebral ischemia." | 3.67 | [Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia]. ( Katayama, Y; Memezawa, H; Minamisawa, H; Shimizu, J; Sugimoto, S; Suzuki, S; Terashi, A, 1986) |
| "The effects of antiedematous agent with intravenous 10% glycerol on cerebral blood flow (CBF) and metabolism were studied in acute cerebral ischemia experimentally induced by bilateral carotid artery occlusion in spontaneously hypertensive rats (SHR)." | 3.67 | Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats. ( Fujishima, M; Ibayashi, S; Ishitsuka, T; Sadoshima, S; Shiokawa, O; Yoshida, F, 1986) |
| "The protective effect of vinpocetine on experimental brain ischemia was studied in stroke-prone spontaneously hypertensive rats (SHRSP) with bilateral carotid artery occlusion (BCAO) and in Wistar-Kyoto rats (WKY) subjected to BCAO and hemorrhage (1% of body weight)." | 3.66 | [Protective effect of vinpocetine on experimental brain ischemia]. ( Hamajo, K; Kakihana, M; Nagaoka, A; Shibota, M; Suno, M, 1982) |
| "Thirteen subarachnoid hemorrhage patients (age, 48." | 2.71 | Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study. ( Amthauer, H; Haux, D; Küchler, I; Lüdemann, L; Plotkin, M; Sarrafzadeh, AS; Unterberg, AW, 2004) |
| " The previously unstudied dose-response also was evaluated in our study." | 2.38 | Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats. ( Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "Delayed cerebral ischemia (DCI), which encompasses all neurobiological events occurring in the subacute-late stage after aSAH, has a complex pathogenesis and can occur in the absence of instrumental vasospasm." | 1.91 | Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. ( Balducci, MT; Blagia, M; Bozzi, MT; Chibbaro, S; de Gennaro, L; De Robertis, M; Messina, R; Pop, R; Severac, F; Signorelli, F, 2023) |
| "Delayed cerebral ischemia (DCI) is a devastating complication of aneurysmal subarachnoid hemorrhage (ASAH) causing brain infarction and disability." | 1.91 | Early brain metabolic disturbances associated with delayed cerebral ischemia in patients with severe subarachnoid hemorrhage. ( Aboudhiaf, S; Balança, B; Barcelos, GK; Carrillon, R; Dailler, F; Grousson, S; Lieutaud, T; Marinesco, S; Perret-Liaudet, A; Tholance, Y, 2023) |
| "Hyperlactatemia was defined as a lactate level of over 2 mmol/L." | 1.62 | Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk. ( Ak, R; Cimilli Ozturk, T; Kırkpantur, ED; Sakal, C; Taşçı, A; Ünal Akoğlu, E, 2021) |
| "In a proof-of-concept porcine model of cardiac arrest, the integrated analysis system proved reliable in a challenging environment resembling a clinical setting; noise levels were found to be comparable with those seen in the lab and were not affected by major clinical interventions such as defibrillation of the heart." | 1.56 | Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model. ( Boutelle, MG; Gowers, SAN; Jeyaprakash, S; Karlsson, M; Murray, DRK; Møller, K; Olsen, MH; Rogers, ML; Samper, IC; Smith, GK, 2020) |
| "The pathophysiology of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) has not been fully evaluated." | 1.56 | Lactate and Lactate Dehydrogenase in Cistern as Biomarkers of Early Brain Injury and Delayed Cerebral Ischemia of Subarachnoid Hemorrhage. ( Anan, M; Fudaba, H; Fujiki, M; Nagai, Y, 2020) |
| "OBJECTIVE Delayed cerebral ischemia (DCI) following subarachnoid hemorrhage (SAH) is one of the major contributors to poor outcome." | 1.48 | Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage. ( Enblad, P; Engquist, H; Hillered, L; Howells, T; Johnson, U; Lewén, A; Nilsson, P; Ronne-Engström, E; Rostami, E, 2018) |
| "Cerebral ischemia is a serious possible manifestation of diabetic vascular disease." | 1.48 | Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats. ( Dave, KR; Perez-Pinzon, MA; Rehni, AK; Shukla, V, 2018) |
| "In this study, we used a global cerebral ischemia induced by four-vessel occlusion as an established animal model for ischemic stroke to investigate metabolic changes after 24 h reperfusion, when transitions occur due to the onset of delayed neuronal death." | 1.48 | NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia. ( Baranovicova, E; Cierny, D; Grendar, M; Kalenska, D; Lehotsky, J; Tomascova, A, 2018) |
| "Delayed cerebral ischemia occurred in 84 patients (29%), and 106 patients (39%) had poor outcome." | 1.43 | Early Circulating Lactate and Glucose Levels After Aneurysmal Subarachnoid Hemorrhage Correlate With Poor Outcome and Delayed Cerebral Ischemia: A Two-Center Cohort Study. ( Bakker, J; Dijkland, SA; Dippel, DW; Nijsten, MW; van den Bergh, WM; van der Jagt, M; van Donkelaar, CE, 2016) |
| "According to previous studies, cerebral ischemia was defined as lactate/pyruvate (LP) ratio > 30 with intracerebral pyruvate level < 70 µmol L(-1)." | 1.42 | Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis. ( Andersen, ÅB; Jacobsen, A; Larsen, L; Nielsen, TH; Nordström, CH; Poulsen, FR; Schalén, W; Schulz, M, 2015) |
| "Aneurysmal subarachnoid hemorrhage (SAH) is frequently associated with delayed neurological deterioration (DND)." | 1.40 | Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage. ( Jacobsen, A; Nielsen, TH; Nilsson, O; Nordström, CH; Schalén, W, 2014) |
| " To obtain a complete inhibition of the effector limb activation, the advised dosage must be respected." | 1.40 | Eculizumab in anti-factor h antibodies associated with atypical hemolytic uremic syndrome. ( Adams, B; Corazza, F; Dahan, K; Davin, JC; Diamante Chiodini, B; Ismaili, K; Khaldi, K, 2014) |
| "Under global cerebral ischemia, the effect of different brain temperature on cerebral ischemic injury was studied." | 1.40 | Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures. ( Li, L; Mei, YW; Murong, SX; Sun, SG; Tong, ET; Xu, GY; Zhang, H; Zhang, JJ, 2014) |
| "Stroke was induced by permanent middle cerebral artery occlusion in rats." | 1.38 | Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. ( Deuchar, GA; Gallagher, L; Holmes, WM; Lopez-Gonzalez, MR; Macrae, IM; Santosh, C, 2012) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Cell-based therapies for global cerebral ischemia represent promising approaches for neuronal damage prevention and tissue repair promotion." | 1.37 | Neuroprotective properties of marrow-isolated adult multilineage-inducible cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers. ( Curtis, KM; D'Ippolito, G; Della-Morte, D; Garbayo, E; Gomez, LA; Howard, GA; Montero-Menei, CN; Perez-Pinzon, MA; Perez-Stable, C; Raval, AP; Reiner, T; Schiller, PC, 2011) |
| "Embolism is responsible for half of cerebral infarctions, yet few animal models were developed due to the unpredictability of the embolus-induced infarcts." | 1.37 | Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain. ( Kuo, YM; Tsai, MJ; Tsai, YH, 2011) |
| "We utilized a global cerebral ischemia model induced by arresting the heart with a combination of hypovolemia and intracardiac injections of a cold potassium chloride solution in order to study the potential therapeutic benefits of human mesenchymal stem cells (hMSCs) on global cerebral ischemia." | 1.36 | Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia. ( Hamada, H; Harada, K; Honmou, O; Houkin, K; Kocsis, JD; Liu, H; Miyata, K; Suzuki, J; Zheng, W, 2010) |
| "Ventricular fibrillation was induced by angioplasty-balloon occlusion of the left coronary artery." | 1.35 | Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation. ( Epstein, A; Farstad, M; Grong, K; Husby, P; Nordrehaug, JE; Pettersen, RJ; Rotevatn, S; Tuseth, V; Wentzel-Larsen, T, 2009) |
| "Alzheimer's disease is characterized by beta-amyloid plaques, tau pathology, cell death of cholinergic neurons, inflammatory processes and cerebrovascular damage." | 1.35 | [Does acidosis in brain play a role in Alzheimer's disease?]. ( Humpel, C; Pirchl, M, 2009) |
| "Cerebral ischemia was assumed when neurologic deterioration occurred." | 1.35 | The accuracy of jugular bulb venous monitoring in detecting cerebral ischemia in awake patients undergoing carotid endarterectomy. ( Kasprzak, P; Metz, C; Moritz, S; Taeger, K; Woertgen, C, 2008) |
| "In addition, the TBI-induced cerebral infarction, motor and proprioception deficits, and body weight loss evaluated 3 days after TBI were significantly attenuated by brain cooling." | 1.34 | Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats. ( Chang, CP; Chio, CC; Hsiao, SH; Kuo, JR; Lin, MT, 2007) |
| "After subarachnoid hemorrhage (SAH) cerebral metabolism is significantly impaired." | 1.34 | Cerebral energy failure after subarachnoid hemorrhage: the role of relative hyperglycolysis. ( Böker, DK; Oertel, MF; Scharbrodt, W; Schmidinger, A; Schwedler, M; Stein, M; Wachter, D, 2007) |
| "Early brain death (within 48 h) was assumed to be due to early global ischemia." | 1.34 | Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences. ( Chieregato, A; Fainardi, E; Marchi, M; Targa, L, 2007) |
| "Mice pathological model of acute cerebral ischemia was established." | 1.34 | [Effect of salvianolic acid B on brain energy metabolism and hydrocephalus of cerebral ischemia in mice at different time]. ( Huang, QF; Jiang, YF; Liu, ZQ; Ren, LW; Wang, Q; Wang, WR; Wang, XM; Zhang, Y, 2007) |
| "Treatment with buflomedil attenuated ischemia-induced histological loss and damage of CA1 pyramidal cells." | 1.33 | Protective effect of buflomedil in a rat model of moderate cerebral ischemia. ( Briguglio, FS; De Pasquale, A; Galluzzo, M; Mondello, MR; Raneri, E; Saija, A; Trombetta, D, 2005) |
| "Cerebral ischemia is recognized as one of the most important mechanisms responsible for secondary brain damage following severe traumatic brain injury (TBI), contributing to an increased mortality and a worse neurologic outcome." | 1.33 | Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system. ( Bullock, RM; Choi, S; Gilman, C; Kunene, NK; Mazzeo, AT, 2006) |
| "Incomplete cerebral ischemia induced was induced by ligating bilateral arteries carotis communis for 20 min followed by reperfusion 48 h in rats." | 1.33 | [Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils]. ( Liu, GQ; Lv, LL; Sun, R, 2006) |
| "In idiopathic adult hydrocephalus syndrome (IAHS), a pathophysiological model of "chronic ischaemia" caused by an arteriosclerotic process in association with a CSF hydrodynamic disturbance has been proposed." | 1.32 | Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome. ( Agren-Wilsson, A; Bergenheim, AT; Eklund, A; Koskinen, LO; Malm, J; Roslin, M, 2003) |
| "In the treatment of patients with aneurysmal subarachnoid hemorrhage (SAH), early occlusion of the aneurysm is necessary as well as monitoring and treatment of complications following the primary bleeding episode." | 1.32 | Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Kristensen, SR; Schulz, M; Skjøth-Rasmussen, J, 2004) |
| " Our results demonstrate that glucose per se, but not lactate, in combination with acidosis mediates the detrimental hyperglycemic effect through a mechanism independent of ionotropic glutamate receptors." | 1.32 | Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro. ( Asztély, F; Cronberg, T; Rytter, A; Söder, A; Wieloch, T, 2004) |
| "Focal cerebral ischemia was induced by occlusion of the unilateral common carotid artery and the middle cerebral artery for 60 minutes followed by 180 minutes of reperfusion." | 1.32 | Microdialysis analyzer and flame atomic absorption spectrometry in the determination of blood glucose, lactate and magnesium in gerbils subjected to cerebral ischemia/reperfusion. ( Cheng, FC; Huang, YL; Lee, JB; Lin, MC; Liu, HW; Yang, DY, 2004) |
| "To validate this assay, a focal cerebral ischemia was produced by occlusion of one common carotid artery for 60 min and then reperfusion for additional 3 h in awake gerbils." | 1.31 | Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils. ( Chen, SH; Cheng, FC; Lee, CW; Tsai, TH; Yan, DY; Yang, LL, 2000) |
| "Lactic acidosis has been implicated; however, increases in the excitotoxic amino acid glutamate, which correlate with increased neuronal damage, may be the cause for the increased damage seen in hyperglycemic stroke." | 1.31 | The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex. ( Diaz, FG; Guyot, LL; O'Regan, MH; Phillis, JW; Song, D, 2001) |
| "Focal cerebral ischemia-reperfusion model in rats was employed to study the protective effects of Sal B." | 1.31 | Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats. ( Chen, YH; Du, GH; Zhang, JT, 2000) |
| "It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients." | 1.31 | Mitochondrial disease and stroke. ( Aguilera, I; Arenas, J; Bautista, J; Campos, Y; Chinchón, I; Fernández-López, O; García-Lozano, R; Gil-Peralta, A; Martínez-Fernández, E, 2001) |
| "In vivo models of cerebral ischemia pose a conceptual challenge when compared to in vitro models." | 1.31 | Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental. ( Miller, JJ; Payne, RS; Schurr, A; Tseng, MT, 2001) |
| "Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia." | 1.31 | Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002) |
| "Forty patients (35 after subarachnoid hemorrhage and 5 after complex aneurysm surgery) were monitored for a total of 174 days (mean, 4 d; range, 1-12 d)." | 1.31 | Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes. ( Al-Rawi, PG; Gupta, AK; Hutchinson, PJ; Kett-White, R; Kirkpatrick, PJ; Pickard, JD, 2002) |
| "The focal cerebral ischemia was produced by the occlusion of the right common carotid artery and the right middle cerebral artery for 60 mins." | 1.31 | Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. ( Cheng, FC; Chung, SY; Lin, JY; Lin, MC, 2002) |
| "Cerebral ischemia was induced, using the bilateral carotid artery occlusion method, for 20 or 60 min, followed by reperfusion up to 120 min." | 1.30 | The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain. ( Fukuchi, T; Kamiya, T; Kashiwagi, F; Katayama, Y; McKee, A; Terashi, A, 1998) |
| "Global cerebral ischemia and increased anaerobic metabolism were considered according to AVDO2 and AVDL respectively." | 1.30 | Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia? ( Ausina, A; Báguena, M; Ferrer, A; Garnacho, A; Manrique, S; Nadal, M; Sahuquillo, J, 1998) |
| "In case of fatal hydrocephalus, high lactate levels were observed throughout the whole brain." | 1.30 | In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus. ( Braun, KP; de Graaf, RA; Gooskens, RH; Nicolay, K; Tulleken, KA; Vandertop, WP, 1998) |
| "Hypoxic-ischemic encephalopathy did not develop in any of the normal newborns but did develop in 16 of the 40 newborns with asphyxia." | 1.30 | Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy. ( Chang, YC; Huang, CC; Lin, KP; Wang, ST; Wu, PL, 1999) |
| "It is suggested that cerebral ischemia acidosis could be improved by hemodilution, in addition to the clearance of lactate acid." | 1.29 | [Hemodilution therapy for cerebral ischemic acidosis]. ( Shi, YS, 1993) |
| "To observe the influence of prolonged cardiac arrest times on neurologic outcome and heart resuscitability, using a resuscitation model with cardiopulmonary bypass in the rabbit, and to determine whether the changes in the plasma concentrations of lactate and lipoperoxide correlate with the severity of global brain ischemia." | 1.29 | Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits. ( Ogata, H; Xu, X, 1994) |
| "To evaluate the occurrence of global cerebral ischemia in acute brain trauma with acute anemia by combined measurements of cerebral hemodynamics, oxygenation, and lactate production." | 1.29 | Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia. ( Cruz, J; Hoffstad, OJ; Jaggi, JL, 1994) |
| "Before cardiac arrest, the blood plasma glucose concentration in seven newborn (113 d postconception; normal gestation, 115 d) and seven 1-mo-old (144 d postconception) piglets was adjusted to a specific value (range, 1 to 64 mM), and then inspired ventilation gases were changed to 10:50:40 CO2:O2:N2 for 20 min." | 1.29 | The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates. ( Corbett, RJ; Garcia, D; Laptook, AR; Sterett, R; Tollefsbol, G, 1993) |
| "Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors." | 1.29 | Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field. ( Inubushi, T; Ishii, H; Morikawa, S; Shigemori, S; Takahashi, K, 1996) |
| "and 1-h cerebral ischemia was then induced by bilateral carotid artery occlusion (group 1)." | 1.28 | Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats. ( Fujishima, M; Ibayashi, S; Nakane, H; Okada, Y; Ooboshi, H; Sadoshima, S, 1992) |
| "During cerebral ischemia, lactate accumulation was greatest in the hippocampus, followed by the cerebral cortex and striatum." | 1.28 | Regional cerebral metabolites, blood flow, plasma volume, and mean transit time in total cerebral ischemia in the rat. ( Crumrine, RC; LaManna, JC, 1991) |
| "It is indicated that both models of cerebral ischemia were simple and sensitive methods for studying brain ischemia." | 1.28 | [Brain energy metabolism of cerebral ischemic mice and the effects of some drugs]. ( Chen, BT; Feng, YP; Sun, YD; Ye, G; Zeng, GY, 1989) |
| " Because higher doses of DCA may be more effective, the main objective of our study was to examine the dose-response of brain tissue lactate to DCA." | 1.28 | Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. ( Cammenga, R; Dimlich, RV; Kaplan, J; Timerding, BL; Van Ligten, PF, 1989) |
| "The cerebral ischemia was induced by bilateral common carotid artery ligation (BLCL) and the survival rate, cerebral blood flow, cerebral energy metabolites (ATP, lactate c-AMP) and water content were measured." | 1.27 | [Experimental cerebral ischemia after bilateral common carotid artery ligation in SHRSP, SHRSR and Wistar rats: correlation between blood pressure and degree of ischemia]. ( Akashi, A; Inamura, K; Katayama, Y; Sekiguchi, F; Sugimoto, S; Suzuki, S; Terashi, A, 1984) |
| "After the cerebral ischemia, the ventriculosubarachnoid space was perfused with an oxygenated fluorocarbon nutrient solution (OFNS) or modified Elliott's B solution (ES) (control perfusion)." | 1.27 | Severe cerebral ischemia treatment by ventriculosubarachnoid perfusion with an oxygenated fluorocarbon emulsion. ( Alderman, JB; D'Amore, BR; Frazer, G; Osterholm, JL; Triolo, AJ; Williams, HD, 1983) |
| "Pulmonary changes in acute cerebral ischemia were studied in anesthetized Mongolian gerbils, in which both carotid arteries were occluded simultaneously." | 1.27 | Pulmonary hemorrhage in experimental cerebral ischemia in mongolian gerbils. Brain metabolism and lung pathology. ( Fujishima, M; Ishitsuka, T; Nakatomi, Y; Ogata, J; Omae, T; Sadoshima, S; Tamaki, K, 1984) |
| "Focal cerebral ischemia in the rat was induced by occlusion of the left middle cerebral artery." | 1.27 | Temporal evolution of regional energy metabolism following focal cerebral ischemia in the rat. ( Assumel-Lurdin, C; Duverger, D; MacKenzie, ET; Nowicki, JP, 1988) |
| "Complete cerebral ischemia was produced for 11 min in 16 dogs, followed by reperfusion for 70 min." | 1.27 | Nimodipine does not affect cerebral lactate levels following complete ischemia in dogs. ( Michenfelder, JD; Milde, JH, 1987) |
| "Hyperglycemia was induced by intraperitoneal injection of 50% glucose and same volume of 50% D-mannitol or physiological saline were injected intraperitoneally 20 minutes before MCA occlusion in control rats." | 1.27 | [The effect of hyperglycemia on ischemic brain damage: relevance to the local cerebral blood flow]. ( Aizawa, S; Kojima, M; Sako, K; Suzuki, N; Yonemasu, Y; Yura, S, 1986) |
| "Rates of lactate accumulation during cerebral ischemia increased progressively from embryonic day 9 through hatching." | 1.26 | Ontogeny of cerebral oxidative metabolism in the chick embryo. ( Gonya-Magee, T; Vannucci, RC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (15.80) | 18.7374 |
| 1990's | 104 (29.89) | 18.2507 |
| 2000's | 105 (30.17) | 29.6817 |
| 2010's | 64 (18.39) | 24.3611 |
| 2020's | 20 (5.75) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, C | 1 |
| Qiao, X | 1 |
| Guo, J | 1 |
| Yang, T | 1 |
| Wang, M | 2 |
| Ma, Y | 1 |
| Zhao, S | 1 |
| Ding, L | 1 |
| Liu, H | 2 |
| Wang, J | 1 |
| Messina, R | 3 |
| de Gennaro, L | 3 |
| De Robertis, M | 3 |
| Pop, R | 3 |
| Chibbaro, S | 3 |
| Severac, F | 3 |
| Blagia, M | 3 |
| Balducci, MT | 3 |
| Bozzi, MT | 3 |
| Signorelli, F | 3 |
| Xu, J | 1 |
| Ji, T | 1 |
| Li, G | 2 |
| Zhang, H | 4 |
| Zheng, Y | 1 |
| Li, M | 2 |
| Ma, J | 1 |
| Li, Y | 1 |
| Chi, G | 1 |
| Ho, WM | 1 |
| Schmidt, FA | 1 |
| Thomé, C | 2 |
| Petr, O | 1 |
| Colucci, ACM | 1 |
| Tassinari, ID | 1 |
| Loss, EDS | 1 |
| de Fraga, LS | 1 |
| Bhatti, MS | 1 |
| Frostig, RD | 1 |
| Tholance, Y | 1 |
| Aboudhiaf, S | 1 |
| Balança, B | 1 |
| Barcelos, GK | 1 |
| Grousson, S | 2 |
| Carrillon, R | 1 |
| Lieutaud, T | 1 |
| Perret-Liaudet, A | 2 |
| Dailler, F | 2 |
| Marinesco, S | 1 |
| Bastian, C | 1 |
| Quinn, J | 1 |
| Doherty, C | 1 |
| Franke, C | 1 |
| Faris, A | 1 |
| Brunet, S | 1 |
| Baltan, S | 2 |
| Mamouei, M | 1 |
| Qassem, M | 1 |
| Budidha, K | 1 |
| Baishya, N | 1 |
| Vadgama, P | 1 |
| Kyriacou, PA | 1 |
| Gowers, SAN | 1 |
| Samper, IC | 1 |
| Murray, DRK | 1 |
| Smith, GK | 1 |
| Jeyaprakash, S | 1 |
| Rogers, ML | 1 |
| Karlsson, M | 1 |
| Olsen, MH | 1 |
| Møller, K | 1 |
| Boutelle, MG | 2 |
| Takata, T | 1 |
| Nonaka, W | 1 |
| Iwama, H | 1 |
| Kobara, H | 1 |
| Deguchi, K | 1 |
| Masugata, H | 1 |
| Touge, T | 1 |
| Miyamoto, O | 1 |
| Nakamura, T | 1 |
| Itano, T | 1 |
| Masaki, T | 1 |
| Anan, M | 1 |
| Nagai, Y | 1 |
| Fudaba, H | 1 |
| Fujiki, M | 1 |
| Hyacinthe, JN | 1 |
| Buscemi, L | 1 |
| Lê, TP | 1 |
| Lepore, M | 1 |
| Hirt, L | 4 |
| Mishkovsky, M | 1 |
| Hosmann, A | 1 |
| Milivojev, N | 1 |
| Dumitrescu, S | 1 |
| Reinprecht, A | 1 |
| Weidinger, A | 1 |
| Kozlov, AV | 1 |
| Dopico-López, A | 1 |
| Pérez-Mato, M | 1 |
| da Silva-Candal, A | 1 |
| Iglesias-Rey, R | 1 |
| Rabinkov, A | 1 |
| Bugallo-Casal, A | 1 |
| Sobrino, T | 1 |
| Mirelman, D | 1 |
| Castillo, J | 2 |
| Campos, F | 1 |
| Gul, Z | 1 |
| Buyukuysal, RL | 1 |
| Pin-Barre, C | 1 |
| Hugues, N | 1 |
| Constans, A | 1 |
| Berton, E | 1 |
| Pellegrino, C | 1 |
| Laurin, J | 1 |
| Lu, X | 1 |
| Zhang, Y | 2 |
| Wang, L | 1 |
| Gao, J | 1 |
| Wang, Y | 3 |
| Sakal, C | 1 |
| Ak, R | 1 |
| Taşçı, A | 1 |
| Kırkpantur, ED | 1 |
| Ünal Akoğlu, E | 1 |
| Cimilli Ozturk, T | 1 |
| Mölström, S | 1 |
| Nielsen, TH | 5 |
| Nordström, CH | 7 |
| Forsse, A | 2 |
| Möller, S | 1 |
| Venö, S | 1 |
| Mamaev, D | 1 |
| Tencer, T | 1 |
| Schmidt, H | 1 |
| Toft, P | 1 |
| Rostami, E | 1 |
| Engquist, H | 1 |
| Howells, T | 1 |
| Johnson, U | 1 |
| Ronne-Engström, E | 1 |
| Nilsson, P | 1 |
| Hillered, L | 4 |
| Lewén, A | 2 |
| Enblad, P | 4 |
| Ribeiro, MC | 1 |
| Bezerra, TDS | 1 |
| Soares, AC | 1 |
| Boechat-Ramos, R | 1 |
| Carneiro, FP | 1 |
| Vianna, LMS | 1 |
| Faro, LRF | 1 |
| Silva, MVD | 1 |
| Vieira, MP | 1 |
| Monteiro, IO | 1 |
| Ferreira, VM | 1 |
| Luo, YP | 1 |
| Hu, HF | 1 |
| Cao, ZY | 1 |
| Zhang, XZ | 1 |
| Cao, L | 1 |
| Wang, ZZ | 1 |
| Xiao, W | 1 |
| Rehni, AK | 1 |
| Shukla, V | 1 |
| Perez-Pinzon, MA | 2 |
| Dave, KR | 1 |
| Deuchar, GA | 2 |
| Brennan, D | 1 |
| Holmes, WM | 2 |
| Shaw, M | 1 |
| Macrae, IM | 2 |
| Santosh, C | 2 |
| Baranovicova, E | 1 |
| Grendar, M | 1 |
| Kalenska, D | 1 |
| Tomascova, A | 1 |
| Cierny, D | 1 |
| Lehotsky, J | 1 |
| Camara-Lemarroy, CR | 1 |
| Escobedo-Zúñiga, N | 1 |
| Guzmán-de la Garza, FJ | 1 |
| Castro-Garza, J | 1 |
| Vargas-Villarreal, J | 1 |
| Góngora-Rivera, F | 1 |
| Clausen, AH | 1 |
| Poulsen, FR | 2 |
| Simonin, A | 1 |
| Rusca, M | 1 |
| Saliou, G | 1 |
| Levivier, M | 2 |
| Daniel, RT | 2 |
| Oddo, M | 2 |
| Kofler, M | 1 |
| Gaasch, M | 1 |
| Rass, V | 1 |
| Schiefecker, AJ | 1 |
| Ianosi, B | 1 |
| Lindner, A | 1 |
| Beer, R | 1 |
| Stover, JF | 1 |
| Rhomberg, P | 1 |
| Pfausler, B | 1 |
| Schmutzhard, E | 1 |
| Helbok, R | 1 |
| Asgari, S | 1 |
| Vespa, P | 2 |
| Hu, X | 1 |
| Riddle, A | 1 |
| Maire, J | 1 |
| Cai, V | 1 |
| Nguyen, T | 1 |
| Gong, X | 1 |
| Hansen, K | 1 |
| Grafe, MR | 1 |
| Hohimer, AR | 2 |
| Back, SA | 1 |
| Lin, Y | 2 |
| Yu, P | 2 |
| Hao, J | 1 |
| Ohsaka, T | 1 |
| Mao, L | 2 |
| Guan, YM | 1 |
| Zhu, Y | 1 |
| Liu, XC | 1 |
| Huang, HL | 1 |
| Wang, ZW | 2 |
| Liu, B | 1 |
| Zhu, YZ | 1 |
| Wang, QS | 1 |
| Makarova, LM | 1 |
| Prikhod'ko, MA | 1 |
| Pogorelyĭ, VE | 1 |
| Skachilova, SIa | 1 |
| Mirzoian, RS | 1 |
| Jacobsen, A | 2 |
| Nilsson, O | 1 |
| Schalén, W | 3 |
| Diamante Chiodini, B | 1 |
| Davin, JC | 1 |
| Corazza, F | 1 |
| Khaldi, K | 1 |
| Dahan, K | 1 |
| Ismaili, K | 1 |
| Adams, B | 1 |
| Li, L | 1 |
| Xu, GY | 1 |
| Mei, YW | 1 |
| Zhang, JJ | 1 |
| Murong, SX | 1 |
| Sun, SG | 1 |
| Tong, ET | 1 |
| Liu, YQ | 1 |
| Zhao, B | 1 |
| Yan, CL | 1 |
| Wang, RQ | 1 |
| Schulz, M | 2 |
| Andersen, ÅB | 1 |
| Larsen, L | 1 |
| Shemesh, N | 1 |
| Rosenberg, JT | 1 |
| Dumez, JN | 1 |
| Grant, SC | 1 |
| Frydman, L | 1 |
| Dienel, GA | 1 |
| Ju, R | 1 |
| Wen, Y | 1 |
| Gou, R | 1 |
| Xu, Q | 1 |
| Hackett, MJ | 2 |
| Britz, CJ | 1 |
| Paterson, PG | 1 |
| Nichol, H | 1 |
| Pickering, IJ | 1 |
| George, GN | 1 |
| Shen, Z | 1 |
| Jiang, L | 1 |
| Yuan, Y | 1 |
| Deng, T | 1 |
| Zheng, YR | 1 |
| Zhao, YY | 1 |
| Li, WL | 1 |
| Wu, JY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Continuous Monitoring of Cerebral Metabolic State. Combined Intracerebral and Jugular Bulb Microdialysis in Neurocritical Care.[NCT03314779] | 12 participants (Actual) | Observational | 2017-08-28 | Completed | |||
| Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury[NCT02993549] | 100 participants (Anticipated) | Observational | 2017-09-16 | Recruiting | |||
| MRI for Early Identification of Underlying Pathology in Patients With Acute Intracerebral Hemorrhage[NCT01689402] | 60 participants (Actual) | Observational | 2012-04-30 | Completed | |||
| Cerebral Autoregulation in Patients With Aneurysmal SubArachnoid Haemorrhage[NCT03987139] | 45 participants (Anticipated) | Interventional | 2019-06-15 | Active, not recruiting | |||
| Exogenous Sodium Lactate Infusion in Traumatic Brain Injury (ELI-TBI)[NCT02776488] | Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to The manufacturer of sodium lactate has stopped making the medication) | ||
| Cerebral Blood Flow (CBF) Disturbances Following Traumatic Brain Injury (TBI) and Subarachnoid Hemorrhage (SAH)[NCT00807833] | 20 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| Safety and Efficacy of Therapeutic Hypothermia in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy: a Prospective, Randomized, Controlled Clinical Study[NCT05779176] | 252 participants (Anticipated) | Interventional | 2023-05-01 | Not yet recruiting | |||
| Clinical Trial of Normobaric Oxygen Therapy in Acute Ischemic Stroke[NCT00414726] | Phase 2 | 85 participants (Actual) | Interventional | 2007-01-31 | Terminated (stopped due to Imbalance in deaths favoring control arm; deaths not attributed to treatment by the blinded external medical monitor.) | ||
| Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus[NCT00858884] | 68 participants (Actual) | Interventional | 2006-08-31 | Completed | |||
| Ketone Esters for Optimization of Cognitive Performance in Hypoxia[NCT03659825] | 16 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 4 hours after starting treatment
| Intervention | 0-4 hour change in NIHSS score (Mean) |
|---|---|
| Normobaric Oxygen | -0.37 |
| Room Air | -0.43 |
The NIHSS score ranges from 0 (best score) to 42 (worst score). (NCT00414726)
Timeframe: 24 hours
| Intervention | 0-24 hour change in NIHSS score (Mean) |
|---|---|
| Normobaric Oxygen | 0.17 |
| Room Air | -0.73 |
19 reviews available for lactic acid and Brain Ischemia
| Article | Year |
|---|---|
CSF metabolomics alterations after aneurysmal subarachnoid hemorrhage: what do we know?
Topics: Biomarkers; Brain Ischemia; Humans; Lactic Acid; Pyruvic Acid; Subarachnoid Hemorrhage | 2023 |
History and Function of the Lactate Receptor GPR81/HCAR1 in the Brain: A Putative Therapeutic Target for the Treatment of Cerebral Ischemia.
Topics: Brain; Brain Ischemia; Cerebral Infarction; Humans; Ischemia; Lactic Acid; Receptors, G-Protein-Coup | 2023 |
Role of Brain Glycogen During Ischemia, Aging and Cell-to-Cell Interactions.
Topics: Aging; Axons; Brain; Brain Ischemia; Cell Communication; Glucose; Glycogen; Lactic Acid; Oligodendro | 2019 |
[Cerebral monitoring of neurocritical patients].
Topics: Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Intracranial Pressure; L | 2018 |
Can lactate serve as an energy substrate for axons in good times and in bad, in sickness and in health?
Topics: Animals; Astrocytes; Axons; Biological Transport; Brain Ischemia; Cell Communication; Energy Metabol | 2015 |
Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations.
Topics: Animals; Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Lactic Acid; Mitochondria; Oxidation | 2014 |
Lactate, glucose and energy metabolism in the ischemic brain (Review).
Topics: Acidosis, Lactic; Anaerobiosis; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Corticosteron | 2002 |
Neuroimaging and serologic markers of neurologic injury after cardiac arrest.
Topics: Blood Glucose; Brain; Brain Ischemia; Creatine Kinase; Heart Arrest; Humans; Lactic Acid; Magnetic R | 2006 |
Lactic acidosis in the brain: occurrence, triggering mechanisms and pathophysiological importance.
Topics: Acidosis; Animals; Blood Glucose; Brain; Brain Ischemia; Carbon Dioxide; Glucose; Hypoxia, Brain; In | 1982 |
Cell damage in the brain: a speculative synthesis.
Topics: Acidosis; Animals; Biological Transport, Active; Brain Ischemia; Calcium; Cell Membrane; Cerebrovasc | 1981 |
Cerebral metabolic studies in vivo by combined 1H/31P and 1H/13C NMR spectroscopic methods.
Topics: Acid-Base Equilibrium; Amino Acids; Ammonia; Animals; Brain; Brain Damage, Chronic; Brain Ischemia; | 1993 |
Markers of cerebral ischemia after cardiac surgery.
Topics: Adenylate Kinase; Biomarkers; Brain Ischemia; Cardiac Surgical Procedures; Creatine Kinase; Humans; | 1996 |
Brain anaerobic lactate production: a suicide note or a survival kit?
Topics: Anaerobiosis; Animals; Brain; Brain Ischemia; Energy Metabolism; Hypoxia; Lactic Acid | 1998 |
[Lactate as an indicator of ischemic-traumatic brain injury].
Topics: Animals; Biomarkers; Brain Injuries; Brain Ischemia; Humans; Lactic Acid | 1999 |
[Biochemistry of cerebral ischemia].
Topics: Acidosis, Lactic; Brain; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Humans; Lact | 1999 |
Effect of glucose on perinatal hypoxic-ischemic brain damage.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Damage, Chronic; Brain Ischemia; Glucose; Humans; Hyp | 1992 |
Effects of various doses of sodium dichloroacetate on hyperlactatemia in fed ischemic rats.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
Cyclic nucleotides in stroke and related cerebrovascular disorders.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Adenylyl Cyclas | 1985 |
Cerebral metabolism in ischaemia: neurochemical basis for therapy.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Calcium; Carbon Dioxide; Cerebral Cortex; Energy Metabo | 1985 |
11 trials available for lactic acid and Brain Ischemia
| Article | Year |
|---|---|
Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.
Topics: Adult; Aged; Biomarkers; Brain; Brain Injuries; Brain Ischemia; Cerebral Veins; Energy Metabolism; F | 2021 |
Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury.
Topics: Adult; Brain; Brain Injuries; Brain Ischemia; Female; Glutamic Acid; Humans; Hyperventilation; Lacti | 2002 |
Metabolic counterpart of decreased apparent diffusion coefficient during hyperacute ischemic stroke: a brain proton magnetic resonance spectroscopic imaging study.
Topics: Acute Disease; Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Diffu | 2003 |
Perioperative changes in cerebral ischemic markers in the cerebrospinal fluid after preoperative nimodipine treatment.
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; Biomarkers; Brain Ische | 2003 |
Cerebral ischemia in aneurysmal subarachnoid hemorrhage: a correlative microdialysis-PET study.
Topics: Adult; Aged; Biomarkers; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Ex | 2004 |
Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia.
Topics: Adult; Age Factors; Biomarkers; Brain Injuries; Brain Ischemia; F2-Isoprostanes; Female; Glutamic Ac | 2004 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.
Topics: Acute Disease; Adolescent; Adult; Brain Injuries; Brain Ischemia; Glucose; Humans; Incidence; Lactic | 2005 |
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul | 2006 |
Dexmedetomidine during coronary artery bypass grafting surgery: is it neuroprotective?--A preliminary study.
Topics: Aged; Anesthetics, Intravenous; Biomarkers; Blood Gas Analysis; Brain Ischemia; Coronary Artery Bypa | 2007 |
Magnetic resonance spectroscopy study of oxygen therapy in ischemic stroke.
Topics: Acute Disease; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Ischemia; Diffusion Magnetic Res | 2007 |
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose; | 2000 |
318 other studies available for lactic acid and Brain Ischemia
| Article | Year |
|---|---|
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I | 2022 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Cerebrospinal Fluid Lactate and Glucose Levels as Predictors of Symptomatic Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage.
Topics: Blood Glucose; Blood Glucose Self-Monitoring; Brain Ischemia; Cerebral Infarction; Humans; Lactic Ac | 2023 |
Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen-glucose deprivation conditions.
Topics: Animals; Astrocytes; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Inflammation; Lact | 2022 |
Astrocyte-neuron lactate shuttle plays a pivotal role in sensory-based neuroprotection in a rat model of permanent middle cerebral artery occlusion.
Topics: Animals; Astrocytes; Brain Ischemia; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; | 2023 |
Early brain metabolic disturbances associated with delayed cerebral ischemia in patients with severe subarachnoid hemorrhage.
Topics: Brain; Brain Ischemia; Cerebral Infarction; Glucose; Glutamic Acid; Humans; Lactic Acid; Pyruvic Aci | 2023 |
Comparison of a Genetic Algorithm Variable Selection and Interval Partial Least Squares for quantitative analysis of lactate in PBS.
Topics: Algorithms; Brain Ischemia; Humans; Lactic Acid; Least-Squares Analysis; Stroke | 2019 |
Real-time neurochemical measurement of dynamic metabolic events during cardiac arrest and resuscitation in a porcine model.
Topics: Aerococcus; Animals; Aspergillus niger; Biomarkers; Biosensing Techniques; Brain; Brain Ischemia; Ca | 2020 |
Light exercise without lactate elevation induces ischemic tolerance through the modulation of microRNA in the gerbil hippocampus.
Topics: Animals; Brain Ischemia; Gene Expression Regulation; Gerbillinae; Hippocampus; Lactic Acid; Male; Me | 2020 |
Lactate and Lactate Dehydrogenase in Cistern as Biomarkers of Early Brain Injury and Delayed Cerebral Ischemia of Subarachnoid Hemorrhage.
Topics: Aged; Biomarkers; Brain Ischemia; Female; Humans; Hydrocephalus; L-Lactate Dehydrogenase; Lactic Aci | 2020 |
Evaluating the potential of hyperpolarised [1-
Topics: Animals; Bicarbonates; Biosensing Techniques; Brain Ischemia; Carbon Isotopes; Computer Systems; Dis | 2020 |
Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach.
Topics: Animals; Brain Ischemia; Cerebrum; Energy Metabolism; Female; Glutamic Acid; Humans; Lactic Acid; Ma | 2021 |
Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage.
Topics: Animals; Antibodies; Aspartate Aminotransferase, Cytoplasmic; Brain; Brain Ischemia; Cloning, Molecu | 2021 |
Glutamate-induced modulation in energy metabolism contributes to protection of rat cortical slices against ischemia-induced damage.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Chromatography, High Pressure Liquid; Energy Metabolism; G | 2021 |
Effects of Different High-Intensity Interval Training Regimens on Endurance and Neuroplasticity After Cerebral Ischemia.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Functional Laterality; Hand Strength; High-Intensity Inter | 2021 |
Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment.
Topics: Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Carnosine; Cell Line; Dexamethason | 2021 |
Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short- and long-term mortality risk.
Topics: Brain Ischemia; Hospital Mortality; Humans; Hyperlactatemia; Lactic Acid; Prognosis; Retrospective S | 2021 |
Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage.
Topics: Adult; Aged; Aged, 80 and over; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Cerebr | 2018 |
Hippocampal and cerebellar histological changes and their behavioural repercussions caused by brain ischaemic hypoxia experimentally induced by sodium nitrite.
Topics: Animals; Anxiety; Blood Glucose; Brain Ischemia; Cerebellum; Cholesterol; Depression; Hippocampus; H | 2017 |
[Protective effects of Ginkgo Terpene Lactones Meglumine Injection on focal cerebral ischemia in rats].
Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Creatine Kinase, BB Form; Ginkgo biloba; Glutamic A | 2017 |
Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats.
Topics: Acidosis; Acrylamides; Animals; Brain Ischemia; CA1 Region, Hippocampal; Central Nervous System Agen | 2018 |
Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) Magnetic Resonance Metabolic Imaging Identifies the Penumbra Following Acute Ischemic Stroke.
Topics: Animals; Autoradiography; Brain; Brain Ischemia; Brain Mapping; Carbon Radioisotopes; Contrast Media | 2018 |
NMR metabolomic study of blood plasma in ischemic and ischemically preconditioned rats: an increased level of ketone bodies and decreased content of glycolytic products 24 h after global cerebral ischemia.
Topics: Acetic Acid; Animals; Biomarkers; Blood Glucose; Brain Ischemia; Cerebrovascular Disorders; Creatine | 2018 |
D-Lactate and intestinal fatty acid-binding protein are elevated in serum in patients with acute ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Cross-Sectional Studies; Fatty Acid-Bind | 2021 |
Multimodal Regional Brain Monitoring of Tissue Ischemia in Severe Cerebral Venous Sinus Thrombosis.
Topics: Aged; Anticoagulants; Brain; Brain Ischemia; Cerebral Angiography; Computed Tomography Angiography; | 2019 |
The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients.
Topics: Aged; Aneurysm, Ruptured; Brain; Brain Edema; Brain Ischemia; Cohort Studies; Female; Glucose; Gluta | 2020 |
Is there any association between cerebral vasoconstriction/vasodilatation and microdialysis Lactate to Pyruvate ratio increase?
Topics: Adult; Aged; Algorithms; Brain; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Female; | 2013 |
Hemodynamic and metabolic correlates of perinatal white matter injury severity.
Topics: Analysis of Variance; Animals; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Brain Ischemi | 2013 |
Continuous and simultaneous electrochemical measurements of glucose, lactate, and ascorbate in rat brain following brain ischemia.
Topics: Animals; Ascorbic Acid; Biosensing Techniques; Brain Chemistry; Brain Ischemia; Electrochemistry; El | 2014 |
Effect of human umbilical cord blood mesenchymal stem cell transplantation on neuronal metabolites in ischemic rabbits.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Cord Blood Stem Cell Transplantation; Creati | 2014 |
[Effect of a new derivative of glutamic and apovincaminic acids on brain metabolism in post-ischemic period].
Topics: Acidosis, Lactic; Animals; Blood Glucose; Brain; Brain Ischemia; Cats; Glutamic Acid; Glycine; Lacti | 2014 |
Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage.
Topics: Aged; Biomarkers; Brain Ischemia; Energy Metabolism; Female; Glucose; Glutamic Acid; Glycerol; Human | 2014 |
Eculizumab in anti-factor h antibodies associated with atypical hemolytic uremic syndrome.
Topics: Antibodies, Monoclonal, Humanized; Autoantibodies; Brain; Brain Ischemia; Child; Complement Factor H | 2014 |
Changes of c-fos, malondialdehyde and lactate in brain tissue after global cerebral ischemia under different brain temperatures.
Topics: Animals; Body Temperature; Brain; Brain Ischemia; Cerebral Cortex; Hippocampus; Immunochemistry; Lac | 2014 |
[Effect of JTS caps. treating cerebral ischemia on metabolism and antioxidant system in cerebral ischemia rat].
Topics: Amino Acids; Animals; Antioxidants; Brain; Brain Ischemia; Catalase; Disease Models, Animal; Drugs, | 2014 |
Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Child; Child, Preschool; Disease Transmission, Infectious; | 2015 |
Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebral Angiography; Cerebrovascular Circulation; Choline; | 2014 |
The experimental therapy on brain ischemia by improvement of local angiogenesis with tissue engineering in the mouse.
Topics: Animals; Brain Ischemia; Cell Proliferation; Disease Models, Animal; Endothelial Cells; Gliosis; Hum | 2014 |
In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain.
Topics: Animals; Brain Ischemia; Cerebellum; Creatine; Decapitation; Dissection; Disulfides; Freezing; Lacti | 2015 |
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cells, C | 2015 |
Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke.
Topics: Acidosis, Lactic; Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; | 2015 |
[Metabolic support in surgical treatment in patients with stenotic impairment of carotid arteries].
Topics: Acidosis; Brain; Brain Ischemia; Cardiotonic Agents; Carotid Artery, Internal; Carotid Stenosis; Cat | 2014 |
A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia.
Topics: Animals; Behavior, Animal; Brain Chemistry; Brain Ischemia; Carrier Proteins; Cell Death; Glucose; H | 2015 |
Exendin-4-loaded PLGA microspheres relieve cerebral ischemia/reperfusion injury and neurologic deficits through long-lasting bioactivity-mediated phosphorylated Akt/eNOS signaling in rats.
Topics: Animals; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cerebrovascular Circulation; Cognition | 2015 |
Ischaemic concentrations of lactate increase TREK1 channel activity by interacting with a single histidine residue in the carboxy terminal domain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Brain Ischemia; HEK293 Cells; Histidine; Humans; | 2016 |
Early Circulating Lactate and Glucose Levels After Aneurysmal Subarachnoid Hemorrhage Correlate With Poor Outcome and Delayed Cerebral Ischemia: A Two-Center Cohort Study.
Topics: Aged; Biomarkers; Blood Glucose; Brain Ischemia; Female; Humans; Intensive Care Units; Lactic Acid; | 2016 |
l-Lactate mediates neuroprotection against ischaemia by increasing TREK1 channel expression in rat hippocampal astrocytes in vitro.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Hypoxia; Cell Survival; Glutamic Acid; Hippocampus; Lactic | 2016 |
Biochemical indications of cerebral ischaemia and mitochondrial dysfunction in severe brain trauma analysed with regard to type of lesion.
Topics: Adult; Brain Injuries, Traumatic; Brain Ischemia; Cerebral Infarction; Energy Metabolism; Female; Gl | 2016 |
Concurrent Glycogen and Lactate Imaging with FTIR Spectroscopy To Spatially Localize Metabolic Parameters of the Glial Response Following Brain Ischemia.
Topics: Animals; Brain Ischemia; Glycogen; Immunohistochemistry; Lactic Acid; Male; Mice; Mice, Inbred BALB | 2016 |
Bedside cerebral microdialysis monitoring of delayed cerebral hypoperfusion in comatose patients with poor grade aneurysmal subarachnoid haemorrhage.
Topics: Adult; Aged; Aneurysm, Ruptured; Blood Glucose; Brain; Brain Ischemia; Cohort Studies; Coma; Critica | 2017 |
Brain metabolic pattern analysis using a magnetic resonance spectra classification software in experimental stroke.
Topics: Animals; Brain; Brain Ischemia; Creatine; Image Processing, Computer-Assisted; Inositol; Lactic Acid | 2017 |
Changes in NAA and lactate following ischemic stroke: a serial MR spectroscopic imaging study.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Brain Mapping; Cel | 2008 |
Effect of hypoperfusion and the protein C pathway on the early coagulopathy after traumatic brain injury.
Topics: Adult; Blood Coagulation Disorders; Brain Injuries; Brain Ischemia; Hemoperitoneum; Humans; Lactic A | 2008 |
Fructose-1,6-bisphosphate and fructose-2,6-bisphosphate do not influence brain carbohydrate or high-energy phosphate metabolism in a rat model of forebrain ischemia.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anesthe | 2009 |
Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Cerebral Infarction; Lactic Acid; Male; Nanopar | 2009 |
Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke.
Topics: Acute Disease; Aspartic Acid; Brain Ischemia; Cell Death; Cerebrovascular Circulation; Diffusion Mag | 2009 |
Physiologically relevant online electrochemical method for continuous and simultaneous monitoring of striatum glucose and lactate following global cerebral ischemia/reperfusion.
Topics: Animals; Biosensing Techniques; Brain Ischemia; Carbon; Corpus Striatum; Electrochemical Techniques; | 2009 |
Cerebral energy failure following experimental cardiac arrest Hypothermia treatment reduces secondary lactate/pyruvate-ratio increase.
Topics: Animals; Brain; Brain Ischemia; Cardiopulmonary Resuscitation; Cerebrovascular Circulation; Disease | 2009 |
Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke.
Topics: Aged; Aged, 80 and over; Body Temperature; Brain; Brain Ischemia; Fever; Humans; Lactic Acid; Magnet | 2009 |
Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat.
Topics: Acetates; Acute Disease; Amino Acids; Animals; Arterial Occlusive Diseases; Astrocytes; Brain Chemis | 2009 |
Initiation time of post-ischemic hypothermia on the therapeutic effect in cerebral ischemic injury.
Topics: Animals; Brain; Brain Ischemia; Chi-Square Distribution; Disease Models, Animal; Electrolytes; Hypot | 2009 |
Percutaneous left ventricular assist device can prevent acute cerebral ischaemia during ventricular fibrillation.
Topics: Acute Disease; Animals; Blood Flow Velocity; Brain Ischemia; Cardiac Catheterization; Cerebrovascula | 2009 |
Neuroprotective role of lactate after cerebral ischemia.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Hippo | 2009 |
MR diffusion and perfusion parameters: relationship to metabolites in acute ischaemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; D | 2010 |
[Does acidosis in brain play a role in Alzheimer's disease?].
Topics: Acidosis; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Brain; Brain Ischemia; Cell | 2009 |
Therapeutic benefits of human mesenchymal stem cells derived from bone marrow after global cerebral ischemia.
Topics: Analysis of Variance; Animals; Bone Marrow Cells; Brain Ischemia; Brain-Derived Neurotrophic Factor; | 2010 |
The cerebral microcirculation is protected during experimental hemorrhagic shock.
Topics: Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Blood Volume; Brain; Brain Ischemi | 2010 |
Metabolic alterations induced by ischemia in primary cultures of astrocytes: merging 13C NMR spectroscopy and metabolic flux analysis.
Topics: Adenosine Triphosphate; Amino Acids; Amino Acids, Branched-Chain; Animals; Astrocytes; Bioreactors; | 2010 |
Correlation between lactate and neuronal cell damage in the rat brain after focal ischemia: An in vivo 1H magnetic resonance spectroscopic (1H-MRS) study.
Topics: Analysis of Variance; Animals; Apoptosis; Aspartic Acid; Biomarkers; Brain; Brain Ischemia; Creatini | 2010 |
Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome.
Topics: Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Cerebral Hemorrhage, Traumatic; Energy Metabol | 2010 |
[The effects of lycopene on reactive oxygen species and anoxic damage in ischemia reperfusion injury in rats].
Topics: Animals; Antioxidants; Brain Ischemia; Carotenoids; Hippocampus; Infarction, Middle Cerebral Artery; | 2010 |
Venous obstruction and cerebral perfusion during experimental cardiopulmonary bypass.
Topics: Animals; Biomarkers; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Cardiopulmonary Bypass; Cent | 2010 |
Relevance of cerebral interleukin-6 after aneurysmal subarachnoid hemorrhage.
Topics: Biomarkers; Brain Ischemia; C-Reactive Protein; Critical Care; Encephalitis; Extracellular Fluid; Fe | 2010 |
Brain choline concentration. Early quantitative marker of ischemia and infarct expansion?
Topics: Aged; Aged, 80 and over; Brain; Brain Ischemia; Brain Mapping; Cerebral Infarction; Choline; Creatin | 2010 |
Acute depression of energy metabolism after microdialysis probe implantation is distinct from ischemia-induced changes in mouse brain.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Energy Metabolism; Glucose; Glutamates; Glycero | 2011 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Neuroprotective properties of marrow-isolated adult multilineage-inducible cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers.
Topics: Animals; Biomimetic Materials; Bone Marrow Cells; Brain Ischemia; Cell Differentiation; Cells, Cultu | 2011 |
Mild-to-moderate hypothermia in aortic arch surgery using circulatory arrest: a change of paradigm?
Topics: Aged; Aorta, Thoracic; Aortic Diseases; Biomarkers; Blood Vessel Prosthesis Implantation; Brain Isch | 2012 |
Antegrade cerebral perfusion with mild hypothermia for aortic arch replacement: single-center experience in 245 consecutive patients.
Topics: Acute Kidney Injury; Aged; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Brain Ischemia; Cardiopulmona | 2011 |
Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Chitin; Embolism; | 2011 |
Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity.
Topics: Animals; Brain Ischemia; Diffusion; Infarction, Middle Cerebral Artery; Lactic Acid; Magnetic Resona | 2012 |
High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice.
Topics: Animals; Aspartic Acid; Brain Ischemia; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Infarct | 2012 |
Preconditioning with L-alanyl-L-glutamine in a Mongolian gerbil model of acute cerebral ischemia/reperfusion injury.
Topics: Animals; Blood Glucose; Brain Ischemia; Dipeptides; Disease Models, Animal; Gerbillinae; Ischemic Pr | 2011 |
Nanoerythropoietin is 10-times more effective than regular erythropoietin in neuroprotection in a neonatal rat model of hypoxia and ischemia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Erythropoietin; Ex | 2012 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
Initial hyperlactatemia in the ED is associated with poor outcome in patients with ischemic stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Brain Ischemia; Emergency Service, Hospital; Fem | 2012 |
The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Delayed-Action Preparations; Disease Models, Anima | 2012 |
[Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
Topics: Animals; Brain Ischemia; Drugs, Chinese Herbal; Fructose; Glyceric Acids; Hydroxyproline; Lactic Aci | 2012 |
HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Biological Availability; Blood-Brain | 2013 |
Neuroprotective effects of lactate in brain ischemia: dependence on anesthetic drugs.
Topics: Anesthetics; Animals; Brain Ischemia; Female; Lactic Acid; Mice; Neuroprotective Agents | 2013 |
Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Brain Chemi | 2013 |
Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study.
Topics: Aged; Amides; Arachidonic Acids; Brain; Brain Chemistry; Brain Ischemia; Endocannabinoids; Ethanolam | 2002 |
Extracellular lactate/pyruvate and glutamate changes in patients during per-operative episodes of cerebral ischaemia.
Topics: Adult; Aged; Biomarkers; Brain; Brain Ischemia; Carotid Artery, Internal; Craniotomy; Glutamic Acid; | 2002 |
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals.
Topics: Acid Sensing Ion Channels; Acidosis; Animals; Arachidonic Acid; Brain Ischemia; Cations; gamma-Amino | 2002 |
Traumatic brain injury and subarachnoid hemorrhage: in vivo occult pathology demonstrated by magnetic resonance spectroscopy may not be "ischaemic". A primary study and review of the literature.
Topics: Adolescent; Adult; Aspartic Acid; Brain; Brain Injuries; Brain Ischemia; Child; Choline; Creatine; C | 2002 |
Alpha-stat strategy: cause of ischemia in brains with old cerebral infarction despite selective cerebral hypothermic antegrade perfusion.
Topics: Brain; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Humans; Hydrogen-Ion Concen | 2002 |
Does acute hyperventilation cause cerebral ischemia in severely head-injured patients?
Topics: Brain Injuries; Brain Ischemia; Glutamic Acid; Humans; Hyperventilation; Lactic Acid; Respiration, A | 2002 |
Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome.
Topics: Aged; Blood Glucose; Brain; Brain Ischemia; Cerebrospinal Fluid; Cerebrospinal Fluid Shunts; Female; | 2003 |
Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs.
Topics: Animals; Brain Chemistry; Brain Ischemia; Calcium; Creatine Kinase; Creatine Kinase, MB Form; Diseas | 2003 |
Hypothermia attenuates circulatory shock and cerebral ischemia in experimental heatstroke.
Topics: Animals; Brain Chemistry; Brain Damage, Chronic; Brain Ischemia; Cerebrovascular Circulation; Corpus | 2003 |
Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Deferoxamine; Electroencephalography; Iron Chelating | 2003 |
Neuronal damage after ischemic injury in the middle cerebral arterial territory: deep watershed versus territorial infarction at MR perfusion and spectroscopic imaging.
Topics: Aspartic Acid; Blood Volume; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Co | 2003 |
Effect of hypervolaemic haemodilution on cerebral glutamate, glycerol, lactate and free radicals in heatstroke rats.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Free Radicals; Glutamic Acid; Glycerol; | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Delayed neurological deficits detected by an ischemic pattern in the extracellular cerebral metabolites in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Extracellular Space; Female; Glucose; Glycerol; Humans; Lactic Acid; Ma | 2004 |
Compromised metabolic recovery following spontaneous spreading depression in the penumbra.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Cortical Spre | 2004 |
Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro.
Topics: Acidosis; Animals; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Ac | 2004 |
Effect of ischemia on TBARS and lactate production in several cerebral regions of anaesthetised and awake rats.
Topics: Acidosis; Anesthesia; Animals; Brain; Brain Ischemia; Lactic Acid; Lipid Peroxidation; Male; Rats; R | 2004 |
Quantitative T1rho NMR spectroscopy of rat cerebral metabolites in vivo: effects of global ischemia.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatinine; Lactic Acid; Magnetic Resonance | 2004 |
Individual value of brain tissue oxygen pressure, microvascular oxygen saturation, cytochrome redox level, and energy metabolites in detecting critically reduced cerebral energy state during acute changes in global cerebral perfusion.
Topics: Algorithms; Animals; Brain Chemistry; Brain Ischemia; Brain Stem; Capillaries; Cerebrovascular Circu | 2004 |
Assessment of jugular blood oxygen and lactate indices for detection of cerebral ischemia and prognosis.
Topics: Brain Injuries; Brain Ischemia; Coma; Glasgow Coma Scale; Humans; Intracranial Aneurysm; Jugular Vei | 2004 |
Effects of norepinephrine depletion in rats during cerebral post-ischemic reperfusion.
Topics: Animals; Benzylamines; Brain Chemistry; Brain Injuries; Brain Ischemia; Cerebral Cortex; Coloring Ag | 2004 |
Patterns of energy substrates during ischemia measured in the brain by microdialysis.
Topics: Adult; Brain Injuries; Brain Ischemia; Female; Glasgow Coma Scale; Glucose; Glutamic Acid; Humans; H | 2004 |
Beneficial effect of L-arginine for stroke-like episode in MELAS.
Topics: Adolescent; Arginine; Brain; Brain Ischemia; Drug Therapy, Combination; Energy Metabolism; Female; G | 2004 |
Ex vivo analysis of lactate and glucose metabolism in the rat brain under different states of depressed activity.
Topics: Alanine; Analgesics, Opioid; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebrovascular Circul | 2004 |
Microdialysis analyzer and flame atomic absorption spectrometry in the determination of blood glucose, lactate and magnesium in gerbils subjected to cerebral ischemia/reperfusion.
Topics: Animals; Area Under Curve; Blood Glucose; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Disease | 2004 |
The effect of global brain ischemia in normal and diabetic animals: the influence of calcium channel blockers.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Calcium; Calcium Channel Blockers; | 2004 |
Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis.
Topics: Animals; Blood Glucose; Brain Ischemia; Cats; Cortical Spreading Depression; Disease Models, Animal; | 2005 |
pH-stat versus alpha-stat acid-base management strategy during hypothermic circulatory arrest combined with embolic brain injury.
Topics: Animals; Brain; Brain Ischemia; Carbon Dioxide; Cardiopulmonary Bypass; Electroencephalography; Gluc | 2005 |
[Experimental study of protective effect of pueraria compound on the cerebral ischemic injury].
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Drug Combinations; Gerbillinae; Glutathione Peroxidase | 2005 |
The effect of clonidine on cell survival, glutamate, and aspartate release in normo- and hyperglycemic rats after near complete forebrain ischemia.
Topics: Adrenergic alpha-Agonists; Animals; Aspartic Acid; Blood Glucose; Blood Pressure; Brain Chemistry; B | 2005 |
Protective effect of buflomedil in a rat model of moderate cerebral ischemia.
Topics: Animals; Blood Glucose; Brain Ischemia; Cell Death; Cerebrovascular Circulation; Hippocampus; Lactic | 2005 |
Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke.
Topics: Anesthesia; Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Glutamic Acid; | 2005 |
Effect of Polygala tenuifolia root extract on cerebral ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Brain; Brain Ischemia; Gerbillinae; Lactic Acid; Lipid P | 2006 |
Mean arterial pressure about 40 mmHg during CPB is associated with cerebral ischemia in piglets.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cardiopulmonary Bypass; Cerebrovascular Circulation; | 2006 |
A case of Melas (A3243G) on chronic dichloroacetate treatment.
Topics: Adolescent; Brain Ischemia; Dichloroacetic Acid; Disease Progression; DNA Mutational Analysis; Domin | 2006 |
Quantitation of ischemic events after severe traumatic brain injury in humans: a simple scoring system.
Topics: Adult; Age Factors; Brain Chemistry; Brain Injuries; Brain Ischemia; Extracellular Fluid; Female; Gl | 2006 |
Fructose-1,6-bisphosphate supports cerebral energy metabolism in pigs after ischemic brain injury caused by experimental particle embolization.
Topics: Animals; Brain; Brain Ischemia; Circulatory Arrest, Deep Hypothermia Induced; Disease Models, Animal | 2006 |
[Effects of paeoniflorin on cerebral energy metabolism, nitric oxide and nitric oxide synthase after cerebral ischemia in mongoliagerbils].
Topics: Animals; Benzoates; Brain; Brain Ischemia; Bridged-Ring Compounds; Ca(2+) Mg(2+)-ATPase; Calcium-Tra | 2006 |
Ischemic vasoconstriction and tissue energy metabolism during global cerebral ischemia in gerbils.
Topics: Adenosine Triphosphate; Animals; Arterioles; Brain Ischemia; Carotid Artery, Common; Cerebral Cortex | 2007 |
Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Brain Injuries; Brain Ischemia; Cereb | 2007 |
Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Capillaries; Cells, Cultured; Cerebrovascular Circulat | 2008 |
Cerebral energy failure after subarachnoid hemorrhage: the role of relative hyperglycolysis.
Topics: Adult; Blood Pressure; Brain Diseases, Metabolic; Brain Ischemia; Cerebral Arteries; Cerebrovascular | 2007 |
Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress.
Topics: Acidosis, Lactic; Animals; Animals, Newborn; Astrocytes; Brain Chemistry; Brain Ischemia; Cells, Cul | 2007 |
Association between intracranial pulse pressure levels and brain energy metabolism in a patient with an aneurysmal subarachnoid haemorrhage.
Topics: Aged; Brain; Brain Ischemia; Female; Glutamic Acid; Glycerol; Humans; Intracranial Aneurysm; Intracr | 2007 |
Brain metabolism during a decrease in cerebral perfusion pressure caused by an elevated intracranial pressure in the porcine neocortex.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Glutamic Acid | 2007 |
Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences.
Topics: Adult; Brain Death; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Fem | 2007 |
The accuracy of jugular bulb venous monitoring in detecting cerebral ischemia in awake patients undergoing carotid endarterectomy.
Topics: Aged; Aged, 80 and over; Anesthesia, Conduction; Brain Ischemia; Data Interpretation, Statistical; E | 2008 |
[Effect of salvianolic acid B on brain energy metabolism and hydrocephalus of cerebral ischemia in mice at different time].
Topics: Animals; Benzofurans; Brain; Brain Ischemia; Drugs, Chinese Herbal; Energy Metabolism; Hydrocephalus | 2007 |
Neuroprotective effect of deep hypothermic circulatory arrest with low priming volume: study in a rabbit model.
Topics: Animals; Blood Volume; Brain Ischemia; Chromatography, High Pressure Liquid; Circulatory Arrest, Dee | 2008 |
Effect of combined ultrasound and microbubbles treatment in an experimental model of cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Glutamic Acid; Glycerol; Infarction, Middle Cerebral Artery; La | 2008 |
[Experimental cerebral ischemia after bilateral common carotid artery ligation in SHRSP, SHRSR and Wistar rats: correlation between blood pressure and degree of ischemia].
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ischemia; Carotid Arteries | 1984 |
Severe cerebral ischemia treatment by ventriculosubarachnoid perfusion with an oxygenated fluorocarbon emulsion.
Topics: Animals; Brain Ischemia; Carbon Dioxide; Cats; Cerebral Cortex; Cerebral Ventricles; Electroencephal | 1983 |
Cerebral physiological and metabolic effects of hyperventilation in the neonatal dog.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Ischemia; Carbon Diox | 1984 |
[Brain function and artificial respiration].
Topics: Acid-Base Equilibrium; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Electroencephalo | 1984 |
[Cerebrospinal fluid findings in brain atrophies detected by computer tomography].
Topics: Alcoholism; Atrophy; Brain; Brain Damage, Chronic; Brain Ischemia; Cerebrospinal Fluid Proteins; Enc | 1984 |
Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain; Brain Edema; Brain Ischemia; Dexamethasone; Dose-Re | 1984 |
[Effects of idebenone (CV-2619) on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia].
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Brain Ischemia; Cerebral Cortex; Cerebrovascular Cir | 1984 |
Effects of idebenone (CV-2619) on the concentrations of acetylcholine and choline in various brain regions of rats with cerebral ischemia.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzoquinones; Brain; Brain Ischemia; Choline; Energ | 1984 |
Pulmonary hemorrhage in experimental cerebral ischemia in mongolian gerbils. Brain metabolism and lung pathology.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain; Brain Ischemia; Female; Gerbillinae; Hemorrh | 1984 |
Ontogeny of cerebral oxidative metabolism in the chick embryo.
Topics: Animals; Brain; Brain Ischemia; Chick Embryo; Chickens; Glucose; Glycolysis; Lactates; Lactic Acid; | 1982 |
[Protective effect of vinpocetine on experimental brain ischemia].
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cerebral Cortex; Injections, Intraperitoneal; Lacta | 1982 |
[Effect of recirculation on experimental cerebral ischemia. 3. Therapy].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulatio | 1982 |
Leukotriene B4 as a marker of cerebral dysfunction.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Ischemia; Craniocerebral Trauma; Female; Humans; Intracra | 1995 |
The role of bradykinin in mediating ischemic brain edema in rats.
Topics: Adenosine Triphosphate; Animals; Aprotinin; Blood Pressure; Body Water; Bradykinin; Brain; Brain Ede | 1993 |
[Hemodilution therapy for cerebral ischemic acidosis].
Topics: Acidosis; Animals; Blood Gas Analysis; Brain Ischemia; Dextrans; Female; Hemodilution; Lactates; Lac | 1993 |
Dichloroacetate attenuates neuronal damage in a gerbil model of brain ischemia.
Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Disease Models, Animal; Gerbillinae; Hippocampus; Lact | 1994 |
Liposomes as in-vivo carriers for citicoline: effects on rat cerebral post-ischaemic reperfusion.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Cortex; C | 1994 |
Transient rise of glucose uptake in the fetal rat brain after brief episodes of intrauterine ischemia.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Deoxyglucose; Energy Metabo | 1994 |
[The study of mechanisms and effects of prophylaxis and cure of electroacupuncture against ischemia injury in brain].
Topics: Angiotensin II; Animals; Blood Pressure; Brain Ischemia; Electroacupuncture; Female; Lactates; Lacti | 1994 |
[A possible risk for geriatric risk patients caused by intraoperative disorder of cerebral energy utilization?].
Topics: Aged; Anesthesia, Spinal; Blood-Brain Barrier; Brain Ischemia; Creatine Kinase; Dementia, Vascular; | 1994 |
Changes in metabolites and tissue water status after focal ischemia in cat brain assessed with localized proton MR spectroscopy.
Topics: Animals; Aspartic Acid; Body Water; Brain; Brain Ischemia; Cats; Creatine; Diffusion; Female; Lactat | 1994 |
Proton magnetic resonance spectroscopy in patients with ischemic stroke.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Ischemia; Case-Control Studies; Choline; Creatine; Female; | 1994 |
Experimental study on the optimum flow rate and pressure for selective cerebral perfusion.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cardiopulmonary Bypass; Carotid Arteri | 1995 |
Proton magnetic resonance spectroscopy in suspected vascular ischemic parkinsonism.
Topics: Aged; Aspartic Acid; Brain; Brain Ischemia; Brain Mapping; Energy Metabolism; Female; Humans; Intrac | 1994 |
Relationship between diffusion-weighted MR images, cerebral blood flow, and energy state in experimental brain infarction.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Brain Ischemia; Cerebral Infarction; Cerebr | 1995 |
Neurologic outcome and heart resuscitability with closed-chest cardiopulmonary bypass after prolonged cardiac arrest times in rabbits.
Topics: Analysis of Variance; Animals; Brain Ischemia; Cardiopulmonary Bypass; Disease Models, Animal; Femal | 1994 |
Cerebral lactate-oxygen index in acute brain injury with acute anemia: assessment of false versus true ischemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Anemia; Brain; Brain Injuries; Brain Ischemia; Cerebrovascul | 1994 |
[Cerebral venous oximetry].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Brain Ischemia; Carbon Dioxide; Catheters, Indwel | 1994 |
Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metab | 1994 |
The effect of hypercarbia on age-related changes in cerebral glucose transport and glucose-modulated agonal glycolytic rates.
Topics: Acidosis, Lactic; Age Factors; Animals; Animals, Newborn; Animals, Suckling; Biological Transport; B | 1993 |
Evidence for a preventive action of the vigilance-promoting drug modafinil against striatal ischemic injury induced by endothelin-1 in the rat.
Topics: Amphetamine; Animals; Arousal; Benzhydryl Compounds; Blood Pressure; Brain Ischemia; Cerebrovascular | 1993 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium C | 1993 |
Early ischaemia after severe head injury. Preliminary results in patients with diffuse brain injuries.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brain; Brain Concussion; Brain Dama | 1993 |
Energy reserves and utilization rates in developing brain measured in vivo by 31P and 1H nuclear magnetic resonance spectroscopy.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Energy Metabolism; Glucose; Lactates; Lactic Acid; | 1993 |
Cerebral extraction of oxygen, lactate production, and perfusion pressure in gunshot wound to the head: case report.
Topics: Adult; Blood Gas Analysis; Brain Injuries; Brain Ischemia; Cerebrovascular Circulation; Humans; Lact | 1996 |
A fast method for in vivo lactate imaging.
Topics: Animals; Brain Ischemia; Gerbillinae; Image Processing, Computer-Assisted; Lactates; Lactic Acid; Ma | 1995 |
The stress of being restrained reduces brain damage after a hypoxic-ischaemic insult in the 7-day-old rat.
Topics: Animals; Animals, Newborn; Blood Chemical Analysis; Blood Glucose; Body Temperature; Brain; Brain Is | 1996 |
Mapping of lactate and N-acetyl-L-aspartate predicts infarction during acute focal ischemia: in vivo 1H magnetic resonance spectroscopy in rats.
Topics: Animals; Aspartic Acid; Biomarkers; Brain Ischemia; Cerebral Infarction; Lactates; Lactic Acid; Magn | 1996 |
99Tcm-HMPAO SPET and 1H-MRS (proton magnetic resonance spectroscopy) in patients with ischaemic cerebral infarction.
Topics: Adult; Aged; Aspartic Acid; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Cholin | 1996 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
The effect of hyperglycemia on cerebral metabolism during hypoxia-ischemia in the immature rat.
Topics: Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Carotid Arteries; Glucose; Glyco | 1996 |
Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia.
Topics: Asphyxia Neonatorum; Brain; Brain Ischemia; Case-Control Studies; Humans; Hypoxia, Brain; Infant, Ne | 1996 |
Imaging focal reperfusion injury following global ischemia with diffusion-weighted magnetic resonance imaging and 1H-magnetic resonance spectroscopy.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Lactic Acid; Magnetic Resonance I | 1996 |
Intracerebral trafficking of lactate in vivo during stress, exercise, electroconvulsive shock and ischemia as studied with microdialysis.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Electrochemistry; Electroshock; Lactic Acid; Male; | 1996 |
Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Diffusion; Lactic Acid; Magnetic R | 1996 |
Age-related ischemia in the brain following bilateral carotid artery occlusion--collateral blood flow and brain metabolism.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Suckling; Arterial Occlusive Diseases; Brain; Brain | 1997 |
Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field.
Topics: Acidosis; Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Hydrogen-Ion Concentrati | 1996 |
Effect of brain, body, and magnet bore temperatures on energy metabolism during global cerebral ischemia and reperfusion monitored by magnetic resonance spectroscopy in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Body Temperature; Brain; Brain Ischemia; Energy Meta | 1997 |
Effects of severe global ischemia on N-acetylaspartate and other metabolites in the rat brain.
Topics: Alanine; Animals; Aspartic Acid; Brain; Brain Ischemia; Creatine; Lactic Acid; Magnetic Resonance Im | 1997 |
Effects of fructose-1,6-biphosphate on microsphere-induced cerebral ischemia in the rat.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Coloring Agents; Evans Blue; Female; Fructosedipho | 1997 |
Early cerebral-metabolite quantification in perinatal hypoxic-ischaemic encephalopathy by proton and phosphorus magnetic resonance spectroscopy.
Topics: Adenosine Triphosphate; Aspartic Acid; Brain Diseases, Metabolic; Brain Ischemia; Humans; Infant, Ne | 1997 |
[The protective effects of dichloroacetate on cerebral ischemia after reperfusion of fed rats].
Topics: Animals; Brain Ischemia; Dichloroacetic Acid; Lactic Acid; Male; Neuroprotective Agents; Random Allo | 1996 |
Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Brain Damage, Chronic; Brain Ischemia; Brain Mapping; Choline; Creatine | 1997 |
The effect of glucose during ischemia on brain ATP, lactate, and glutamate in piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Body Temperature; Brain; Brain Chemistry; Brain I | 1997 |
Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Choline; Creatine; Image Processing, Computer-Assiste | 1998 |
Oxygen consumption and energy state in an in vitro model of rat brain perfused with artificial oxygen carrier.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Brain; Brain Ischem | 1998 |
The effect of duration of cerebral ischemia on brain pyruvate dehydrogenase activity, energy metabolites, and blood flow during reperfusion in gerbil brain.
Topics: Adenosine Triphosphate; Animals; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Energ | 1998 |
Cortical brain microdialysis and temperature monitoring during hypothermic circulatory arrest in humans.
Topics: Acid-Base Equilibrium; Adult; Aged; Body Temperature Regulation; Brain Ischemia; Brain Stem; Cerebra | 1998 |
Hyperglycemia increases neurological damage and behavioral deficits from post-traumatic secondary ischemic insults.
Topics: Animals; Behavior, Animal; Blood Gas Analysis; Blood Glucose; Blood Pressure; Body Temperature; Body | 1998 |
Effect of hyperglycemia on brain cell membrane function and energy metabolism during hypoxia-ischemia in newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cell Membrane; Energy Meta | 1998 |
Extracellular ischaemia markers in repeated global ischaemia and secondary hypoxaemia monitored by microdialysis in rat brain.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Electroencephalography; Energy Metabolism; Extracellular S | 1998 |
Effects of glutathione depletors on post-ischemic reperfusion in rat brain.
Topics: Animals; Brain; Brain Ischemia; Glutathione; Lactic Acid; Male; Maleates; Rats; Rats, Wistar; Reperf | 1998 |
Age-related differences in the effect of dichloroacetate on postischemic lactate and acid clearance measured in vivo using magnetic resonance spectroscopy and microdialysis.
Topics: Acids; Aging; Animals; Animals, Newborn; Body Temperature; Brain; Brain Ischemia; Dichloroacetic Aci | 1998 |
Strategy for lipid suppression in lactate imaging using STIR-DQCT: a study of hypoxic-ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Hypoxia, Brain; Image Enhancement; Lactic Acid; Magnetic Resonance S | 1998 |
Magnetic resonance spectroscopy of high-energy phosphates and lactate immediately after coronary artery bypass surgery.
Topics: Brain Ischemia; Cardiac Surgical Procedures; Coronary Artery Bypass; Humans; Lactic Acid; Magnetic R | 1998 |
Cerebral hemodynamic changes during sustained hypocapnia in severe head injury: can hyperventilation cause cerebral ischemia?
Topics: Adolescent; Adult; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Female; Hemodynamics; Home | 1998 |
Brain ischemia detected by tissue-PO2 measurement and the lactate-oxygen index in head injury.
Topics: Brain; Brain Concussion; Brain Injuries; Brain Ischemia; Humans; Lactic Acid; Oxygen; Oxygen Consump | 1998 |
Jugular bulb monitoring of cerebral oxygen metabolism in severe head injury: accuracy of unilateral measurements.
Topics: Brain; Brain Injuries; Brain Ischemia; Coma; Dominance, Cerebral; Female; Humans; Jugular Veins; Lac | 1998 |
In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus.
Topics: Acute Disease; Analysis of Variance; Animals; Brain; Brain Edema; Brain Ischemia; Chronic Disease; D | 1998 |
Maturational changes in cerebral lactate and acid clearance following ischemia measured in vivo using magnetic resonance spectroscopy and microdialysis.
Topics: Acidosis, Lactic; Age Factors; Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Lactic Ac | 1999 |
Rapid on-line microdialysis hyphenated technique for the dynamic monitoring of extracellular pyruvate, lactic acid and ascorbic acid during cerebral ischemia.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Extracellular Space; Gerbillinae; Lactic Acid; Microdialysis | 1999 |
Metabolite changes in neonatal rat brain during and after cerebral hypoxia-ischemia: a magnetic resonance spectroscopic imaging study.
Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Brain; Brain Ischemia; Cerebral Infarction; Female; | 1999 |
Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats.
Topics: Acidosis, Lactic; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Injuries; Br | 1999 |
Relation of impaired energy metabolism to apoptosis and necrosis following transient cerebral hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Brain Ischemia; Cell Count; Energy Metabolism; Gyrus Ci | 1998 |
Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals. Generalized spectral localization by imaging.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Disorders; Disease Models, Animal; Filtration; Gerbi | 1999 |
Energy metabolism and NAD-NADH redox state in brain slices in response to glutamate exposure and ischemia.
Topics: Animals; Brain; Brain Ischemia; Energy Metabolism; Glutamic Acid; Hydrogen-Ion Concentration; In Vit | 1999 |
Effects of hypoxia-ischemia and inhibition of nitric oxide synthase on cerebral energy metabolism in newborn piglets.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Anima | 1999 |
Measurement of the urinary lactate:creatinine ratio for the early identification of newborn infants at risk for hypoxic-ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Biomarkers; Brain Ischemia; Creatinine; Developmental Disabilities; Fetal Hypox | 1999 |
Markers of asphyxia and neonatal brain injury.
Topics: Asphyxia Neonatorum; Biomarkers; Brain Ischemia; Creatinine; Fetal Hypoxia; Humans; Hypoxia, Brain; | 1999 |
Adenosine: a sensitive indicator of cerebral ischemia during carotid endarterectomy.
Topics: Adenosine; Adenosine Triphosphate; Aged; Brain; Brain Ischemia; Cerebrovascular Circulation; Endarte | 1999 |
Lactate reduces amino acid release and fuels recovery of function in the ischemic brain.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Electroencephalography; Injections; Lactic Ac | 1999 |
Bedside detection of brain ischemia using intracerebral microdialysis: subarachnoid hemorrhage and delayed ischemic deterioration.
Topics: Adult; Aged; Biomarkers; Blood Glucose; Brain Ischemia; Cerebral Cortex; Female; Glutamic Acid; Glyc | 1999 |
Continuous monitoring of cerebrospinal fluid acid-base balance and oxygen metabolism in patients with severe head injury: pathophysiology and treatments for cerebral acidosis and ischemia.
Topics: Acidosis; Adolescent; Adult; Brain Injuries; Brain Ischemia; Carbon Dioxide; Fever; Glasgow Coma Sca | 1999 |
Antioxidant LY231617 enhances electrophysiologic recovery after global cerebral ischemia in dogs.
Topics: Animals; Antioxidants; Blood Glucose; Brain; Brain Ischemia; Butylated Hydroxytoluene; Dogs; Electro | 2000 |
Monitoring of extracellular pyruvate, lactate, and ascorbic acid during cerebral ischemia: a microdialysis study in awake gerbils.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Gerbillinae; Lactic Acid; Microdialysis; Pyruvic Acid | 2000 |
Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain I | 2000 |
Chronic effects of an aminosteroid on microdialytically measured parameters after experimental middle cerebral artery occlusion in the rat.
Topics: Animals; Ascorbic Acid; Brain Ischemia; Drug Evaluation, Preclinical; Free Radicals; Glucose; Infarc | 2000 |
The effect of topical insulin on the release of excitotoxic and other amino acids from the rat cerebral cortex during streptozotocin-induced hyperglycemic ischemia.
Topics: Administration, Topical; Animals; Aspartic Acid; Blood Glucose; Brain Ischemia; Cerebral Cortex; Dia | 2000 |
Pyruvate dehydrogenase activity and energy metabolite levels following bilateral common carotid artery occlusion in rat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Carotid Artery, Common; Cerebral Cortex; Cor | 2000 |
Inhibition of Na(+)/H(+) exchange by 5-(N-ethyl-N-isopropyl)-amiloride reduces free fatty acid efflux from the ischemic reperfused rat cerebral cortex.
Topics: Acidosis; Amiloride; Animals; Brain Ischemia; Cardiovascular Physiological Phenomena; Cerebral Corte | 2000 |
Anaerobic glycolysis is crucial for the maintenance of neural activity in guinea pig hippocampal slices.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Brain Ischemia; Energy Metabolism; Fructose; Glu | 2000 |
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease | 2001 |
The impact of hypercarbia on the evolution of brain injury in a porcine model of traumatic brain injury and systemic hemorrhage.
Topics: Animals; Axons; Blood Pressure; Brain; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cardiac Outpu | 2001 |
The effect of streptozotocin-induced diabetes on the release of excitotoxic and other amino acids from the ischemic rat cerebral cortex.
Topics: Acute Disease; Amino Acids; Animals; Blood Glucose; Brain Ischemia; Cerebral Cortex; Chronic Disease | 2001 |
Mismatch between lactate and the apparent diffusion coefficient of water in progressive focal ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Diffusion; Lactic Acid; Ligation; Magnetic Resonance Spectro | 2001 |
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Carrier Proteins; Coumaric Acids; Energy Metabolism; H | 2001 |
Two-voxel localization sequence for in vivo two-dimensional homonuclear correlation spectroscopy.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Ischemia; Dominance, Cerebral; Energy Metabolism; Image | 2001 |
Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Benzofurans; Brain; Brain Ischemia; Lactic Acid; Male | 2000 |
Changes in regional energy metabolism after closed head injury in the rat.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Injuries; Brain Ischemia; Encephalitis; Energy Metabol | 2001 |
Further studies on the effects of topical lactate on amino acid efflux from the ischemic rat cortex.
Topics: Administration, Topical; Amino Acids; Animals; Brain Ischemia; Cardiovascular Physiological Phenomen | 2001 |
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Glutamic Acid; Hypoxanthine; Infarction | 2001 |
Metabolic changes in pericontusional oedematous areas in mild head injury evaluated by 1H MRS.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Concussion; Brain Edema; Brain Ischemia; Creati | 2000 |
Cerebral hypoperfusion in immediate postoperative period following coronary artery bypass grafting, heart valve, and abdominal aortic surgery.
Topics: Aged; Anesthesia, General; Aorta, Abdominal; Brain Ischemia; Carbon Dioxide; Cardiopulmonary Bypass; | 2001 |
Is ischemia involved in the pathogenesis of murine cerebral malaria?
Topics: Adenosine Triphosphate; Alanine; Amino Acids; Animals; Brain; Brain Ischemia; Chromatography, High P | 2001 |
Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions.
Topics: Adult; Aged; Brain; Brain Injuries; Brain Ischemia; Energy Metabolism; Female; Glucose; Glycerol; Hu | 2001 |
Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion.
Topics: Animals; Brain Ischemia; Corpus Striatum; Energy Metabolism; Extracellular Space; Glucose; Glutamic | 2001 |
Mitochondrial disease and stroke.
Topics: Adolescent; Adult; Brain Ischemia; DNA, Mitochondrial; Female; Humans; Lactic Acid; Male; Mitochondr | 2001 |
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ede | 2001 |
Neurometabolic changes during treatment with moderate hypothermia in a patient suffering from severe middle cerebral artery infarction.
Topics: Adult; Brain Ischemia; Extracellular Space; Glutamic Acid; Glycerol; Humans; Hypothermia, Induced; I | 2001 |
Preischemic hyperglycemia-aggravated damage: evidence that lactate utilization is beneficial and glucose-induced corticosterone release is detrimental.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Glucose; Brain Ischemia; Corticostero | 2001 |
Diffusion-weighted in vivo localized proton MR spectroscopy of human cerebral ischemia and tumor.
Topics: Adult; Aspartic Acid; Brain Ischemia; Brain Neoplasms; Cerebral Infarction; Creatine; Diffusion; Fem | 2002 |
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M | 2002 |
Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes.
Topics: Brain; Brain Ischemia; Carbon Dioxide; Cerebral Angiography; Cerebral Infarction; Disabled Persons; | 2002 |
Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Energy Metabolism; Gerbillinae; Gluco | 2002 |
Effect of dichloroacetate on recovery of brain lactate, phosphorus energy metabolites, and glutamate during reperfusion after complete cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cations; Dichloroacetic Acid; Disease Models, Anima | 1992 |
Glucose-associated alterations in ischemic brain metabolism of neonatal piglets.
Topics: Adenosine Triphosphate; Age Factors; Animals; Animals, Newborn; Blood Glucose; Blood-Brain Barrier; | 1992 |
CSF ascorbic acid and lactate levels after neonatal asphyxia: preliminary results.
Topics: Ascorbic Acid; Asphyxia Neonatorum; Brain Ischemia; France; Hospitals, University; Humans; Infant, N | 1992 |
Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain; Brain Ischemia; Calcium Channel Blockers; Ce | 1992 |
Brain energy metabolites in mice intoxicated with acrylamide: effects of ischemia.
Topics: Acrylamide; Acrylamides; Adenosine Triphosphate; Animals; Body Weight; Brain; Brain Ischemia; Energy | 1992 |
Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Brain; Brain Ischemia; Dogs; Energy Metabolism; Female; Heart Arrest; Lact | 1992 |
Effects of hyperglycemia on the time course of changes in energy metabolism and pH during global cerebral ischemia and reperfusion in rats: correlation of 1H and 31P NMR spectroscopy with fatty acid and excitatory amino acid levels.
Topics: Acidosis, Lactic; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Energy Metabolism; Fatty | 1992 |
Facilitating postischemic reduction of cerebral lactate in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Dichloroacetic Acid; Lactates; Lactic | 1992 |
Tissue lactate content and tissue PCO2 in complete brain ischaemia: implications for compartmentation of H+.
Topics: Animals; Brain Ischemia; Carbon Dioxide; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Male; Ne | 1991 |
Effect of ischemia and reperfusion on lambda of the lumped constant of the [14C]deoxyglucose technique.
Topics: Adenosine Triphosphate; Algorithms; Animals; Brain Ischemia; Carbon Radioisotopes; Cats; Cerebrovasc | 1992 |
Hemorrhagic infarct conversion in experimental stroke.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cats; Cerebral Arteries; Ce | 1992 |
A new model of focal brain ischemia based on the intracerebral injection of endothelin-1.
Topics: Animals; Brain Chemistry; Brain Ischemia; Corpus Striatum; Densitometry; Disease Models, Animal; Dop | 1991 |
Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Energy Metaboli | 1991 |
The effect of age on glucose-modulated cerebral agonal glycolytic rates measured in vivo by 1H NMR spectroscopy.
Topics: Age Factors; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Injuries; Brain Ischemia; Glycol | 1991 |
A new ergopeptide, CBM 36-733, improves ischaemic cerebral metabolism in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Ergolines; Female; Hemodynamics; Lactates; L | 1991 |
Interstitial and cerebrospinal fluid levels of energy-related metabolites after middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Arteries; Energy Metabolism; Extracel | 1991 |
Regional cerebral metabolites, blood flow, plasma volume, and mean transit time in total cerebral ischemia in the rat.
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebral Cortex; Cerebr | 1991 |
Fetal cerebral blood flow and metabolism during oligemia and early postoligemic reperfusion.
Topics: Animals; Arteries; Blood Glucose; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencepha | 1991 |
Interleaved 1H and 31P spectroscopic imaging for studying regional brain injury.
Topics: Animals; Brain; Brain Ischemia; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magnetic Resonanc | 1991 |
Protection of ischaemic synaptosomes from calcium overload by addition of exogenous lactate.
Topics: Acetylcholine; Animals; Brain Ischemia; Calcium; Hydrogen-Ion Concentration; Hypoxia; Lactates; Lact | 1991 |
Posthypoxic glucose supplement reduces hypoxic-ischemic brain damage in the neonatal rat.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Chemistry; Brain Ischemia; Cerebral Cortex; Cer | 1990 |
[Experimental study on pathogenesis of neonatal hypoxic-ischemic encephalopathy. II. Energy metabolism in the brain].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Brain; Brain Ischemia; Cer | 1990 |
Opiate-receptor antagonist improves metabolic recovery and limits neurochemical alterations associated with reperfusion after global brain ischemia in rats.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Brain Chemistry; Brain Ischemia; Fatty Acids, Nonester | 1990 |
Acid homeostasis following partial ischemia in neonatal brain measured in vivo by 31P and 1H nuclear magnetic resonance spectroscopy.
Topics: Acidosis, Respiratory; Acids; Animals; Animals, Newborn; Brain Ischemia; Energy Metabolism; Homeosta | 1990 |
Increased cerebral lactate output to cerebral venous blood after forebrain ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Veins; Diencephalon; Lactates; Lactic Ac | 1990 |
Brain lactate and neurologic outcome following incomplete ischemia in fasted, nonfasted, and glucose-loaded rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Fasting; Glucose; Lactates; Lactic Acid; Mal | 1990 |
Effect of the calcium entry blocker nimodipine on the metabolism of nucleic acids in rat brain ischemia.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Animals; Brain Chemistry; Brain Ischemia; Energy Metab | 1990 |
Relative cerebral ischemia in SHR due to hypotensive hemorrhage: cerebral function, blood flow and extracellular levels of lactate and purine catabolites.
Topics: Adenosine; Animals; Brain; Brain Ischemia; Cerebral Hemorrhage; Cerebrovascular Circulation; Extrace | 1989 |
Time course of CSF lactate level in subarachnoid haemorrhage. Correlation with clinical grading and prognosis.
Topics: Acid-Base Equilibrium; Adult; Aged; Brain Edema; Brain Ischemia; Coma; Electrolytes; Female; Humans; | 1989 |
Influence of lactate accumulation on calcium content of ischemic and postischemic brain.
Topics: Animals; Blood Glucose; Brain; Brain Ischemia; Calcium; Electroencephalography; Energy Metabolism; L | 1989 |
[Brain energy metabolism of cerebral ischemic mice and the effects of some drugs].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Ginsenosides; Lactates; Lactic Acid; Male; M | 1989 |
Dihydropyridine calcium antagonists reduce the consumption of high-energy phosphates in the rat brain. A study using combined 31P/1H magnetic resonance spectroscopy and 31P saturation transfer.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Brain; Brain Ischemia; Calcium Channel Blockers; Ene | 1989 |
Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia.
Topics: Acetates; Acidosis, Lactic; Animals; Brain Chemistry; Brain Ischemia; Dichloroacetic Acid; Disease M | 1989 |
Nimodipine reduces postischemic lactate levels in the isolated perfused rat brain.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; In Vitro Techniques; Lactates; Lactic A | 1989 |
[Effects of S-adenosyl-L-methionine on experimental cerebral ischemia].
Topics: Acute Disease; Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Cyclic AMP; Disea | 1985 |
[Effect of long-term prior antihypertensive treatment on cerebral ischemia induced by bilateral common carotid artery ligation in SHRSR].
Topics: Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Captopril; Carotid Arteries; Cer | 1986 |
Susceptibility to ischemic insult in hypertensive rats: correlation between degree of ischemia and hypertension.
Topics: Adenosine Triphosphate; Animals; Body Water; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascula | 1986 |
[The effect of glucose and insulin on carbohydrate and prostaglandin metabolism in the ischemic brain].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Brain; Brain Ischemia; Glucose; Insulin; Lactates; Lactic Aci | 1988 |
Effect of recirculation on the recovery of cerebral metabolism after experimental cerebral ischemia in male and female spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cerebrov | 1988 |
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. III. Changes following ischaemia.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gerbillinae; Hydroge | 1988 |
Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulati | 1988 |
Thick brain slices model the ischemic penumbra.
Topics: Animals; Body Water; Brain; Brain Ischemia; Deoxyglucose; Disease Models, Animal; Histological Techn | 1988 |
Cerebral lactic acid delivery and uptake during and after ischemia in the piglet.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Hydrogen-Ion Concentrat | 1987 |
Evidence against major compartmentalization of H+ in ischemic rat brain tissue.
Topics: Animals; Brain; Brain Ischemia; Hydrogen; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Magneti | 1988 |
Influence of ethanol on the energy metabolism of ischemic and postischemic brain.
Topics: Animals; Behavior, Animal; Blood Glucose; Brain; Brain Ischemia; Electroencephalography; Energy Meta | 1988 |
Temporal evolution of regional energy metabolism following focal cerebral ischemia in the rat.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Brain; Brain Ischemia; Energy Metabolism; Lactates; | 1988 |
Nitrous oxide and cerebrospinal fluid markers of ischaemia following cardiopulmonary bypass.
Topics: Adenylate Kinase; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Brain Ischemia; Cardiopu | 1987 |
Brain metabolism and intracellular pH during ischaemia and hypoxia: an in vivo 31P and 1H nuclear magnetic resonance study in the lamb.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Hydrogen-Ion Concentration; Hypoxia, Brain; Lactate | 1987 |
31P and 1H NMR spectroscopy to study the effects of gallopamil on brain ischemia.
Topics: Animals; Brain; Brain Ischemia; Cats; Energy Metabolism; Gallopamil; Lactates; Lactic Acid; Magnetic | 1987 |
Cerebral metabolic responses of hyperglycemic immature rats to hypoxia-ischemia.
Topics: Adenine Nucleotides; Animals; Animals, Newborn; Blood Glucose; Brain; Brain Ischemia; Glucose; Hyper | 1987 |
Hydrogen ions kill brain at concentrations reached in ischemia.
Topics: Acidosis; Animals; Brain; Brain Ischemia; Cerebral Infarction; Hydrogen-Ion Concentration; Lactates; | 1987 |
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. II. Changes during ischaemia.
Topics: Animals; Aspartic Acid; Brain; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Gerbi | 1987 |
Effects of increased ICP on brain phosphocreatine and lactate determined by simultaneous 1H and 31P NMR spectroscopy.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cats; Female; Hydrogen; Hydrogen-Ion Concentration; | 1987 |
Simultaneous 31P- and 1H-nuclear magnetic resonance studies of hypoxia and ischemia in the cat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cats; Electroencephalography; Hydrogen; Hypo | 1987 |
Nimodipine does not affect cerebral lactate levels following complete ischemia in dogs.
Topics: Animals; Brain; Brain Ischemia; Dogs; Energy Metabolism; Female; Lactates; Lactic Acid; Male; Nimodi | 1987 |
Preservation of cerebral metabolites by etomidate during incomplete cerebral ischemia in dogs.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Dogs; Electroencephalography; Energy Metabolism; Et | 1986 |
Hyperbaric oxygen therapy in experimentally induced acute cerebral ischemia.
Topics: Adenosine Triphosphate; Animals; Blood Gas Analysis; Blood Pressure; Brain; Brain Ischemia; Carotid | 1986 |
[Protective effect of thromboxane A2 synthetase inhibitor (trapidil) on acutely-induced cerebral ischemia].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebral Arteries; Lactates; Lactic Acid; Ma | 1986 |
Lactate and pH in the brain: association and dissociation in different pathophysiological states.
Topics: Animals; Brain; Brain Ischemia; Brain Neoplasms; Hydrogen-Ion Concentration; Ischemic Attack, Transi | 1987 |
[The effect of hyperglycemia on ischemic brain damage: relevance to the local cerebral blood flow].
Topics: Animals; Autoradiography; Blood Glucose; Brain; Brain Ischemia; Hyperglycemia; Lactates; Lactic Acid | 1986 |
Regional alterations in glucose consumption and metabolite levels during postischemic recovery in cat brain.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Brain; Brain Ischemia; Carbon Dioxide; Cats; Deoxygl | 1985 |
Effects of intravenous glycerol on cerebral blood flow and tissue metabolism in acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; | 1986 |
Effects of the new eburnamenine derivative RU 24722 on EEG recovery and cerebral energy metabolism after complete ischemia.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Dihydroergotoxine; Electroencephalography; E | 1985 |
Regional quantitative determination of lactate in brain sections. A bioluminescent approach.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Brain Neoplasms; Freeze Drying; Gerbillinae; Glucos | 1985 |
[Lactate concentration in the ventricular fluid and blood plasma following severe craniocerebral trauma].
Topics: Adult; Brain Injuries; Brain Ischemia; Coma; Female; Humans; Hypoxia, Brain; Intracranial Pressure; | 1985 |