lactic acid has been researched along with Brain Edema in 106 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 7.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 7.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 7.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 7.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 7.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 5.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Treatment with bumetanide may help diminish the adverse effects of initial treatment with insulin/saline." | 5.36 | Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. ( Anderson, SE; Glaser, N; O'Donnell, ME; Tancredi, DJ; Yuen, N, 2010) |
| "Increased brain lactate, and not glutamine, is a primary player in the pathogenesis of brain edema in CLD." | 3.80 | Increased brain lactate is central to the development of brain edema in rats with chronic liver disease. ( Bosoi, CR; Huynh, J; Marin, H; Parent-Robitaille, C; Rose, CF; Tremblay, M; Zwingmann, C, 2014) |
| "The pathogenesis of brain edema in an experimental model of ALF involves a cytotoxic mechanism: the metabolism of ammonia in astrocytes induces an increase of glutamine and lactate that appears to mediate cellular swelling." | 3.76 | Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure. ( Alonso, J; Chavarria, L; Cordoba, J; Lope-Piedrafita, S; Oria, M; Romero-Gimenez, J, 2010) |
| "Hyperammonemia causes brain edema and high intracranial pressure (ICP) in acute liver failure (ALF) by accumulation of glutamine in brain." | 3.74 | Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jorgensen, L; Larsen, FS; Tofteng, F, 2008) |
| "Osmotic agents such as glycerol are used to treat brain edema in stroke patients." | 3.73 | Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema. ( Berger, C; Kiening, KL; Sakowitz, OW; Schwab, S, 2005) |
| "Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue." | 3.72 | [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats]. ( Li, CH; Liang, YM; Liu, YS; Qu, HT; Wang, GW, 2004) |
| "Our results gives support to the antiinflammatory effect of dexamethasone in experimental pneumococcal meningitis, and suggest that phenytoin may have also a protective effect on brain ischemia." | 3.69 | [Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis]. ( Cabellos, C; Gudiol, F; Martínez-Lacasa, J; Martos, A; Viladrich, PF, 1995) |
| "We investigated the hypothesis that bradykinin generation may induce ischemic brain edema in spontaneously hypertensive rats." | 3.68 | The role of bradykinin in mediating ischemic brain edema in rats. ( Kamiya, T; Kashiwagi, F; Katayama, Y; Terashi, A, 1993) |
| "In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats." | 3.67 | [Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage]. ( Iakimova, TV; Plotnikov, MB; Plotnikova, TM; Saratikov, AS, 1988) |
| "Brain alterations such as hepatic encephalopathy or brain edema are usually associated with liver failure." | 2.50 | Magnetic resonance of the brain in chronic and acute liver failure. ( Chavarria, L; Cordoba, J, 2014) |
| "SL is an effective therapy for treating brain edema after TBI." | 1.62 | The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach. ( Duhaut, DE; Gandin, C; Heurteaux, C; Ichai, C; Quintard, H, 2021) |
| "Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF)." | 1.39 | Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs. ( Koblihova, E; Laszikova, E; Pantoflicek, T; Prazak, J; Ryska, M; Ryska, O, 2013) |
| "Patients with acute liver failure (ALF) often die of intracranial pressure (IP) and cerebral herniation." | 1.37 | Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. ( Agusti, A; Boix, J; Cauli, O; Cerdán, S; Felipo, V; López-Larrubia, P; Nieto-Charques, L; Rodrigo, R, 2011) |
| "When biochemical signs of cerebral ischemia progressed, i." | 1.37 | Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue. ( Nordström, CH; Reinstrup, P, 2011) |
| "Patients with global cerebral edema on admission (n=24 [62%]) had a higher incidence of metabolic crisis in the first 12 hours of monitoring (n=15 [15% versus 2%], P<0." | 1.37 | Global cerebral edema and brain metabolism after subarachnoid hemorrhage. ( Badjatia, N; Choi, HA; Claassen, J; Connolly, ES; Fernandez, L; Helbok, R; Ko, SB; Kurtz, P; Lee, K; Mayer, SA; Schmidt, JM, 2011) |
| "Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties." | 1.37 | Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats. ( Kiening, KL; Sakowitz, OW; Simunovic, F; Unterberg, AW; Zweckberger, K, 2011) |
| "Treatment with bumetanide may help diminish the adverse effects of initial treatment with insulin/saline." | 1.36 | Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide. ( Anderson, SE; Glaser, N; O'Donnell, ME; Tancredi, DJ; Yuen, N, 2010) |
| "Previous studies of spontaneous subarachnoid hemorrhage (SAH) have shown that global cerebral edema on the first computed tomography scan is associated with a more severe initial injury and is an independent predictor of poor outcome." | 1.36 | Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema. ( Enblad, P; Hallberg, L; Hillered, L; Karlsson, T; Ronne Engström, E; Zetterling, M, 2010) |
| "In 17 patients (aged 18-60 years) with acute liver failure and severe hyperammonemia (182 ± 36 μM (mean ± SD)), cerebral microdialysis was performed, and ICP and CPP were monitored." | 1.36 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure. ( Bjerring, PN; Frederiksen, HJ; Hansen, BA; Hauerberg, J; Jørgensen, L; Larsen, FS; Tofteng, F, 2010) |
| " Reduced IC combined with intracranial volume insults leads to metabolic disturbances in a rat model." | 1.36 | Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat. ( Contant, CF; Enblad, P; Goiny, M; Nilsson, P; Piper, I; Salci, K, 2010) |
| "Perimural edema and hydrocephalus were observed only in patients treated with HydroCoils, but have been reported in patients treated with other modified platinum coils." | 1.35 | Wall enhancement, edema, and hydrocephalus after endovascular coil occlusion of intradural cerebral aneurysms. ( Fanning, NF; ter Brugge, KG; Willinsky, RA, 2008) |
| "PEHO syndrome is a rare symptom complex of severe progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy." | 1.33 | Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome. ( Boltshauser, E; Huisman, TA; Klein, A; Straube, T; Werner, B, 2006) |
| "Fulminant hepatic encephalopathy has a high mortality." | 1.33 | Microdialysis in the management of hepatic encephalopathy. ( Al-Rawi, PG; Czosnyka, M; Gimson, A; Hutchinson, PJ; Menon, DK; O'Connell, MT, 2006) |
| "This complex syndrome is associated with cyclosporine A therapy or a variety of other conditions in which blood pressure rises acutely." | 1.31 | Clinical spectrum of reversible posterior leukoencephalopathy syndrome. ( Koo, J; Kwon, S; Lee, S, 2001) |
| "Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia." | 1.31 | Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002) |
| "In case of fatal hydrocephalus, high lactate levels were observed throughout the whole brain." | 1.30 | In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus. ( Braun, KP; de Graaf, RA; Gooskens, RH; Nicolay, K; Tulleken, KA; Vandertop, WP, 1998) |
| " The optimal dosage of fluconazole and the impact of combination with flucytosine are not known." | 1.29 | Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome. ( Elliott, BR; Kartalija, M; Kaye, K; Liu, Q; Sande, MA; Täuber, MG; Tureen, JH, 1996) |
| "Acid-base balance in cerebral infarction might be affected not only by lactate production but also by complicated interactions with tissue edema and some other factors." | 1.29 | Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field. ( Inubushi, T; Ishii, H; Morikawa, S; Shigemori, S; Takahashi, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (11.32) | 18.7374 |
| 1990's | 20 (18.87) | 18.2507 |
| 2000's | 42 (39.62) | 29.6817 |
| 2010's | 30 (28.30) | 24.3611 |
| 2020's | 2 (1.89) | 2.80 |
| Authors | Studies |
|---|---|
| Duhaut, DE | 1 |
| Heurteaux, C | 1 |
| Gandin, C | 1 |
| Ichai, C | 1 |
| Quintard, H | 1 |
| Kofler, M | 1 |
| Gaasch, M | 1 |
| Rass, V | 1 |
| Schiefecker, AJ | 1 |
| Ianosi, B | 1 |
| Lindner, A | 1 |
| Beer, R | 1 |
| Stover, JF | 2 |
| Rhomberg, P | 1 |
| Pfausler, B | 1 |
| Thomé, C | 2 |
| Schmutzhard, E | 1 |
| Helbok, R | 2 |
| Jiang, YS | 1 |
| Wang, FR | 1 |
| Prazak, J | 1 |
| Laszikova, E | 1 |
| Pantoflicek, T | 1 |
| Ryska, O | 1 |
| Koblihova, E | 1 |
| Ryska, M | 1 |
| Wasser, G | 1 |
| Pattarini, JM | 1 |
| Blue, RS | 1 |
| Aikins, LT | 1 |
| Law, J | 1 |
| Walshe, AD | 1 |
| Garbino, A | 1 |
| Turney, MW | 1 |
| Clark, JB | 1 |
| Chavarria, L | 2 |
| Cordoba, J | 2 |
| Oria, M | 2 |
| Jalan, R | 1 |
| Bosoi, CR | 2 |
| Zwingmann, C | 3 |
| Marin, H | 1 |
| Parent-Robitaille, C | 1 |
| Huynh, J | 1 |
| Tremblay, M | 1 |
| Rose, CF | 3 |
| Ruozi, B | 2 |
| Belletti, D | 2 |
| Forni, F | 2 |
| Sharma, A | 2 |
| Muresanu, D | 1 |
| Mössler, H | 2 |
| Vandelli, MA | 2 |
| Tosi, G | 2 |
| Sharma, HS | 2 |
| Avnstorp, MB | 1 |
| Rasmussen, P | 1 |
| Brassard, P | 1 |
| Seifert, T | 1 |
| Overgaard, M | 1 |
| Krustrup, P | 1 |
| Secher, NH | 1 |
| Nordsborg, NB | 1 |
| Zhu, HT | 1 |
| Bian, C | 1 |
| Yuan, JC | 1 |
| Liao, XJ | 1 |
| Liu, W | 1 |
| Zhu, G | 1 |
| Feng, H | 1 |
| Lin, JK | 1 |
| Muresanu, DF | 1 |
| Tian, R | 1 |
| Han, L | 1 |
| Hou, Z | 1 |
| Hao, S | 1 |
| Mao, X | 1 |
| Zhu, Z | 1 |
| Tao, X | 1 |
| Zhang, Q | 1 |
| Liu, B | 1 |
| Fanning, NF | 1 |
| Willinsky, RA | 1 |
| ter Brugge, KG | 1 |
| Schubert, GA | 1 |
| Poli, S | 1 |
| Schilling, L | 1 |
| Heiland, S | 1 |
| Timaru-Kast, R | 2 |
| Meissner, A | 2 |
| Heimann, A | 3 |
| Hoelper, B | 3 |
| Kempski, O | 4 |
| Alessandri, B | 4 |
| Winter, JD | 1 |
| Tichauer, KM | 1 |
| Gelman, N | 1 |
| Thompson, RT | 1 |
| Lee, TY | 1 |
| St Lawrence, K | 1 |
| Wang, E | 1 |
| Ho, CL | 1 |
| Lee, KK | 1 |
| Ng, I | 1 |
| Ang, BT | 1 |
| Scafidi, S | 1 |
| O'Brien, J | 1 |
| Hopkins, I | 1 |
| Robertson, C | 1 |
| Fiskum, G | 1 |
| McKenna, M | 1 |
| Chernov, MF | 2 |
| Nakaya, K | 1 |
| Kasuya, H | 1 |
| Kato, K | 1 |
| Ono, Y | 2 |
| Yoshida, S | 1 |
| Nakamura, R | 1 |
| Suzuki, T | 1 |
| Muragaki, Y | 1 |
| Iseki, H | 1 |
| Kubo, O | 2 |
| Hori, T | 2 |
| Takakura, K | 2 |
| Lescot, T | 1 |
| Fulla-Oller, L | 2 |
| Po, C | 1 |
| Chen, XR | 1 |
| Puybasset, L | 1 |
| Gillet, B | 1 |
| Plotkine, M | 1 |
| Meric, P | 1 |
| Marchand-Leroux, C | 1 |
| Romero-Gimenez, J | 1 |
| Alonso, J | 1 |
| Lope-Piedrafita, S | 1 |
| Glaser, N | 2 |
| Yuen, N | 2 |
| Anderson, SE | 1 |
| Tancredi, DJ | 1 |
| O'Donnell, ME | 1 |
| Tang, YJ | 1 |
| Zhou, FW | 1 |
| Luo, ZQ | 1 |
| Li, XZ | 1 |
| Yan, HM | 1 |
| Wang, MJ | 1 |
| Huang, FR | 1 |
| Yue, SJ | 1 |
| Keularts, IM | 1 |
| Leroy, PL | 1 |
| Rubio-Gozalbo, EM | 1 |
| Spaapen, LJ | 1 |
| Weber, B | 1 |
| Dorland, B | 1 |
| de Koning, TJ | 1 |
| Verhoeven-Duif, NM | 1 |
| Zetterling, M | 1 |
| Hallberg, L | 1 |
| Hillered, L | 1 |
| Karlsson, T | 1 |
| Enblad, P | 3 |
| Ronne Engström, E | 1 |
| Bjerring, PN | 2 |
| Hauerberg, J | 2 |
| Jørgensen, L | 1 |
| Frederiksen, HJ | 2 |
| Tofteng, F | 2 |
| Hansen, BA | 2 |
| Larsen, FS | 3 |
| Salci, K | 2 |
| Goiny, M | 2 |
| Contant, CF | 1 |
| Piper, I | 2 |
| Nilsson, P | 2 |
| Cauli, O | 1 |
| López-Larrubia, P | 1 |
| Rodrigo, R | 1 |
| Agusti, A | 1 |
| Boix, J | 1 |
| Nieto-Charques, L | 1 |
| Cerdán, S | 1 |
| Felipo, V | 1 |
| Reinstrup, P | 1 |
| Nordström, CH | 2 |
| Ko, SB | 1 |
| Schmidt, JM | 1 |
| Kurtz, P | 1 |
| Fernandez, L | 1 |
| Choi, HA | 1 |
| Connolly, ES | 1 |
| Lee, K | 1 |
| Badjatia, N | 1 |
| Mayer, SA | 1 |
| Claassen, J | 1 |
| Zweckberger, K | 1 |
| Simunovic, F | 1 |
| Kiening, KL | 2 |
| Unterberg, AW | 2 |
| Sakowitz, OW | 3 |
| Ngo, C | 1 |
| Anderson, S | 1 |
| Trifu, A | 1 |
| O'Donnell, M | 1 |
| Preuss, M | 1 |
| Zhang, J | 1 |
| Deng, Z | 1 |
| Liao, J | 1 |
| Song, C | 1 |
| Liang, C | 1 |
| Xue, H | 1 |
| Wang, L | 1 |
| Zhang, K | 1 |
| Yan, G | 1 |
| Gärdenfors, A | 1 |
| Nilsson, F | 1 |
| Skagerberg, G | 1 |
| Ungerstedt, U | 1 |
| Gliemroth, J | 1 |
| Bahlmann, L | 1 |
| Klaus, S | 1 |
| Klöhn, A | 1 |
| Arnold, H | 1 |
| Chatauret, N | 3 |
| Leibfritz, D | 1 |
| Butterworth, RF | 3 |
| Chen, ZG | 1 |
| Lu, YC | 1 |
| Zhu, C | 1 |
| Zhang, GJ | 1 |
| Ding, XH | 1 |
| Jiang, JY | 1 |
| Rose, C | 2 |
| Beyer, TF | 1 |
| Dohse, NK | 1 |
| Kroppenstedt, SN | 1 |
| Thomale, UW | 1 |
| Schaser, KD | 1 |
| Filippi, R | 1 |
| Kopacz, L | 1 |
| Berger, C | 3 |
| Dohmen, C | 3 |
| Maurer, MH | 1 |
| Graf, R | 3 |
| Schwab, S | 3 |
| Hayashi, M | 1 |
| Izawa, M | 1 |
| Maruyama, T | 1 |
| Usukura, M | 1 |
| Parkin, M | 1 |
| Hopwood, S | 1 |
| Jones, DA | 1 |
| Hashemi, P | 1 |
| Landolt, H | 2 |
| Fabricius, M | 1 |
| Lauritzen, M | 1 |
| Boutelle, MG | 1 |
| Strong, AJ | 1 |
| Alexander, JJ | 1 |
| Quigg, R | 1 |
| Liang, YM | 1 |
| Liu, YS | 1 |
| Qu, HT | 1 |
| Wang, GW | 1 |
| Li, CH | 1 |
| Soustiel, JF | 1 |
| Mahamid, E | 1 |
| Chistyakov, A | 1 |
| Shik, V | 1 |
| Benenson, R | 1 |
| Zaaroor, M | 1 |
| Contant, C | 1 |
| Huisman, TA | 1 |
| Klein, A | 1 |
| Werner, B | 1 |
| Straube, T | 1 |
| Boltshauser, E | 1 |
| Reinert, M | 3 |
| Khaldi, A | 1 |
| Zauner, A | 2 |
| Doppenberg, E | 2 |
| Choi, S | 1 |
| Bullock, R | 4 |
| Bosche, B | 1 |
| Reithmeier, T | 1 |
| Ernestus, RI | 1 |
| Brinker, G | 2 |
| Sobesky, J | 1 |
| Heiss, WD | 2 |
| Hutchinson, PJ | 1 |
| Gimson, A | 1 |
| Al-Rawi, PG | 1 |
| O'Connell, MT | 1 |
| Czosnyka, M | 1 |
| Menon, DK | 1 |
| Geeraerts, T | 1 |
| Friggeri, A | 1 |
| Mazoit, JX | 1 |
| Benhamou, D | 1 |
| Duranteau, J | 1 |
| Vigué, B | 1 |
| Marden, FA | 1 |
| Putman, CM | 1 |
| Jorgensen, L | 1 |
| Katayama, Y | 3 |
| Altman, DI | 1 |
| Young, RS | 1 |
| Yagel, SK | 1 |
| Chan, PH | 1 |
| Yurko, M | 1 |
| Fishman, RA | 1 |
| Imura, Y | 1 |
| Kiyota, Y | 1 |
| Nagai, Y | 1 |
| Nishikawa, K | 1 |
| Terashita, Z | 1 |
| Go, KG | 2 |
| Kamman, RL | 2 |
| Mooyaart, EL | 1 |
| Heesters, MA | 2 |
| Pruim, J | 1 |
| Vaalburg, W | 1 |
| Paans, AM | 1 |
| Kamiya, T | 1 |
| Kashiwagi, F | 1 |
| Terashi, A | 2 |
| Martos, A | 1 |
| Cabellos, C | 1 |
| Martínez-Lacasa, J | 1 |
| Viladrich, PF | 1 |
| Gudiol, F | 1 |
| París, MM | 1 |
| Friedland, IR | 1 |
| Ehrett, S | 1 |
| Hickey, SM | 1 |
| Olsen, KD | 3 |
| Hansen, E | 1 |
| Thonar, EJ | 1 |
| McCracken, GH | 3 |
| Ashwal, S | 2 |
| Perkin, RM | 2 |
| Thompson, JR | 1 |
| Schneider, S | 1 |
| Tomasi, LG | 2 |
| Langemann, H | 1 |
| Mendelowitsch, A | 1 |
| Gratzl, O | 1 |
| Mun-Bryce, S | 1 |
| Kroh, FO | 1 |
| White, J | 1 |
| Rosenberg, GA | 1 |
| de Haan, HH | 1 |
| Van Reempts, JL | 1 |
| Vles, JS | 1 |
| de Haan, J | 1 |
| Hasaart, TH | 1 |
| Mallard, EC | 1 |
| Williams, CE | 1 |
| Johnston, BM | 1 |
| Gluckman, PD | 1 |
| Täuber, MG | 4 |
| Sande, E | 1 |
| Fournier, MA | 1 |
| Tureen, JH | 2 |
| Sande, MA | 4 |
| Kartalija, M | 1 |
| Kaye, K | 1 |
| Liu, Q | 1 |
| Elliott, BR | 1 |
| Staub, F | 2 |
| Winkler, A | 1 |
| Haberstok, J | 1 |
| Plesnila, N | 2 |
| Peters, J | 1 |
| Chang, RC | 1 |
| Baethmann, A | 2 |
| Morikawa, S | 2 |
| Inubushi, T | 2 |
| Takahashi, K | 1 |
| Ishii, H | 2 |
| Shigemori, S | 1 |
| Krikke, AP | 1 |
| Nakamura, T | 1 |
| Nagao, S | 1 |
| Kawai, N | 1 |
| Honma, Y | 1 |
| Kuyama, H | 1 |
| Braun, KP | 1 |
| de Graaf, RA | 1 |
| Vandertop, WP | 1 |
| Gooskens, RH | 1 |
| Tulleken, KA | 1 |
| Nicolay, K | 1 |
| Annecke, A | 1 |
| Aschoff, A | 1 |
| Spranger, M | 1 |
| Yamamura, H | 1 |
| Hiraide, A | 2 |
| Matsuoka, T | 1 |
| Takaoka, M | 1 |
| Shimazu, T | 1 |
| Sugimoto, H | 1 |
| Holshouser, BA | 1 |
| Shu, SK | 1 |
| Simmons, PL | 1 |
| Knierim, DS | 1 |
| Sheridan, C | 1 |
| Craig, K | 1 |
| Andrews, GH | 1 |
| Hinshaw, DB | 1 |
| Son, BC | 1 |
| Park, CK | 1 |
| Choi, BG | 1 |
| Kim, EN | 1 |
| Choe, BY | 1 |
| Lee, KS | 1 |
| Kim, MC | 1 |
| Kang, JK | 1 |
| Schuhmann, MU | 1 |
| Stiller, D | 1 |
| Thomas, S | 1 |
| Brinker, T | 1 |
| Samii, M | 1 |
| Eriskat, J | 1 |
| Stoffel, M | 1 |
| Rinecker, M | 1 |
| Chen, T | 1 |
| Qian, YZ | 1 |
| Di, X | 1 |
| Zhu, JP | 1 |
| Young, HF | 1 |
| Schneweis, S | 1 |
| Grond, M | 1 |
| Neveling, M | 1 |
| Kwon, S | 1 |
| Koo, J | 1 |
| Lee, S | 1 |
| Suzuki, M | 2 |
| Sato, K | 1 |
| Dohi, S | 1 |
| Sato, T | 1 |
| Matsuura, A | 1 |
| Therrien, G | 1 |
| Arai, T | 1 |
| Segawa, H | 1 |
| Fukuda, K | 1 |
| Sáez-Llorens, X | 1 |
| Jafari, HS | 1 |
| Severien, C | 1 |
| Parras, F | 1 |
| Hansen, EJ | 1 |
| Singer, II | 1 |
| Bakay, RA | 1 |
| Sweeney, KM | 1 |
| Wood, JH | 1 |
| Shimoda, M | 1 |
| Yamada, S | 1 |
| Yamamoto, I | 1 |
| Tsugane, R | 1 |
| Sato, O | 1 |
| Uenohara, H | 1 |
| Imaizumi, S | 1 |
| Suzuki, J | 1 |
| Yoshimoto, T | 1 |
| Plotnikov, MB | 1 |
| Plotnikova, TM | 1 |
| Iakimova, TV | 1 |
| Saratikov, AS | 1 |
| Borschberg, U | 1 |
| Syrogiannopoulos, GA | 1 |
| Reisch, JS | 1 |
| Shimizu, J | 1 |
| Minamisawa, H | 1 |
| Sugimoto, S | 1 |
| Suzuki, S | 1 |
| Siesjö, BK | 1 |
| Wieloch, T | 1 |
| Khayam-Bashi, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry[NCT01444664] | Phase 4 | 24 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| Cerebral Microdialysis in Patients With Fulminant Hepatic Failure[NCT00836420] | 50 participants (Actual) | Observational | 2000-01-31 | Completed | |||
| Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults[NCT03520569] | Early Phase 1 | 15 participants (Actual) | Interventional | 2019-02-04 | Completed | ||
| Ketone Esters for Optimization of Cognitive Performance in Hypoxia[NCT03659825] | 16 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The augmentation index (AIx) measured at the radial artery is a measure of systemic arterial stiffness, and is defined as the ratio of augmentation (Δ P) to central pulse pressure and expressed as percent. AIx = (ΔP/PP) x 100, where P = pressure and PP = Pulse Pressure. Higher percentages indicate increased arterial stiffness. (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | percentage (Mean) |
|---|---|
| Octreotide- Euglycemia | -4.15 |
| Octreotide - Euglycemia- Insulin Clamp | -2.23 |
| Octreotide- Hyperglycemia | -4.80 |
| Octreotide- Hyperglycemia - Insulin Clamp | -8.45 |
Flow mediated dilation measures the change in brachial diameter in response to 5 minutes of ischemia using B-mode ultrasound. It provides an index of nitric oxide generation by the endothelium . (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | % change (Mean) |
|---|---|
| Octreotide- Euglycemia | 11.8 |
| Octreotide - Euglycemia- Insulin Clamp | 11.8 |
| Octreotide- Hyperglycemia | 8.9 |
| Octreotide- Hyperglycemia - Insulin Clamp | 8.95 |
The time required for a blood pressure wave to travel from the carotid to the femoral artery was measured in meter/sec. This is a measurement of central artery stiffness. Higher numbers indicate stiffer vessels (NCT03520569)
Timeframe: baseline and after 2 hour insulin clamp
| Intervention | m/sec (Mean) |
|---|---|
| Octreotide- Euglycemia | 5.21 |
| Octreotide - Euglycemia- Insulin Clamp | 5.06 |
| Octreotide- Hyperglycemia | 4.79 |
| Octreotide- Hyperglycemia - Insulin Clamp | 5.07 |
7 reviews available for lactic acid and Brain Edema
| Article | Year |
|---|---|
Flat spin and negative Gz in high-altitude free fall: pathophysiology, prevention, and treatment.
Topics: Altitude; Arrhythmias, Cardiac; Blood Glucose; Brain Edema; Cerebrovascular Circulation; Confusion; | 2013 |
Magnetic resonance of the brain in chronic and acute liver failure.
Topics: Aspartic Acid; Biomarkers; Brain; Brain Chemistry; Brain Edema; Choline; Creatine; Glutamic Acid; Gl | 2014 |
Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Brain Edema; Citric Acid Cycle; Dichloroacetic Acid; Drug Evaluation, Precl | 2014 |
Increase brain lactate in hepatic encephalopathy: cause or consequence?
Topics: Animals; Biological Transport, Active; Brain Chemistry; Brain Edema; Energy Metabolism; Hepatic Ence | 2010 |
Bacterial meningitis in children: current concepts of neurologic management.
Topics: Adolescent; Adrenal Cortex Hormones; Algorithms; Animals; Anti-Infective Agents; Brain Edema; Cerebr | 1994 |
Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury.
Topics: Acetylcholine; Brain Edema; Brain Injuries; Calcium; Cerebrospinal Fluid Proteins; Dopamine; Fatty A | 1986 |
Cerebral metabolism in ischaemia: neurochemical basis for therapy.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Calcium; Carbon Dioxide; Cerebral Cortex; Energy Metabo | 1985 |
5 trials available for lactic acid and Brain Edema
| Article | Year |
|---|---|
Effects of temperature changes on cerebral biochemistry in spontaneous intracerebral hematoma.
Topics: Adult; Aged; Analysis of Variance; Brain Chemistry; Brain Edema; Cerebral Hemorrhage; Female; Glutam | 2008 |
Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: relationship with depolarisation-like events.
Topics: Adult; Aged; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Cortical Spreading Depression; Ele | 2005 |
Comparison of moderate hyperventilation and mannitol for control of intracranial pressure control in patients with severe traumatic brain injury--a study of cerebral blood flow and metabolism.
Topics: Adolescent; Adult; Aged; Brain Edema; Brain Injuries; Brain Ischemia; Cerebral Cortex; Cerebrovascul | 2006 |
The origin of lactate in peritumoral edema as measured by proton-magnetic resonance spectroscopic imaging.
Topics: Brain Edema; Brain Neoplasms; Glioma; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Protons | 1997 |
Predictive value of neurochemical monitoring in large middle cerebral artery infarction.
Topics: Adult; Aged; Brain Edema; Critical Care; Electrodes, Implanted; Extracellular Space; Female; Frontal | 2001 |
94 other studies available for lactic acid and Brain Edema
| Article | Year |
|---|---|
The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.
Topics: Animals; Brain Edema; Brain Injuries, Traumatic; Intracranial Hypertension; Intracranial Pressure; L | 2021 |
The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients.
Topics: Aged; Aneurysm, Ruptured; Brain; Brain Edema; Brain Ischemia; Cohort Studies; Female; Glucose; Gluta | 2020 |
Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
Topics: 3-Hydroxybutyric Acid; Animals; Brain Edema; Brain Neoplasms; Caloric Restriction; Cell Line, Tumor; | 2013 |
Cerebral microdialysis reflects the neuroprotective effect of fractionated plasma separation and adsorption in acute liver failure better and earlier than intracranial pressure: a controlled study in pigs.
Topics: Ammonia; Animals; Brain Edema; Cerebrum; Extracorporeal Circulation; Glucose; Glutamic Acid; Glutami | 2013 |
Ischemic stroke penumbra and extracorporeal ozone treatment.
Topics: Adenosine Triphosphate; Apoptosis; Brain Edema; Disabled Persons; Disease Progression; Glutathione R | 2013 |
Brain lactate in hepatic encephalopathy: friend or foe?
Topics: Animals; Brain; Brain Edema; Hepatic Encephalopathy; Lactic Acid; Liver Diseases; Male | 2014 |
Increased brain lactate is central to the development of brain edema in rats with chronic liver disease.
Topics: Ammonia; Animals; Brain; Brain Edema; Chronic Disease; Glutamine; Hepatic Encephalopathy; Lactic Aci | 2014 |
Poly (D,L-lactide-co-glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury.
Topics: Analysis of Variance; Animals; Brain Concussion; Brain Edema; Disease Models, Animal; Lactic Acid; M | 2014 |
Cerebral water and ion balance remains stable when humans are exposed to acute hypoxic exercise.
Topics: Acid-Base Equilibrium; Adult; Altitude Sickness; Body Water; Brain; Brain Chemistry; Brain Edema; Ex | 2015 |
Hyperbaric oxygen therapy ameliorates acute brain injury after porcine intracerebral hemorrhage at high altitude.
Topics: Altitude; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Glutamic Acid; Hyperbaric Oxygenation; L | 2015 |
PLGA Nanoparticles Loaded Cerebrolysin: Studies on Their Preparation and Investigation of the Effect of Storage and Serum Stability with Reference to Traumatic Brain Injury.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain Edema; Brain Injuries; Delayed-Action Preparations; | 2015 |
Neuroprotective efficacy of decompressive craniectomy after controlled cortical impact injury in rats: An MRI study.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Choline; Creatine; Decompressive Craniec | 2015 |
Wall enhancement, edema, and hydrocephalus after endovascular coil occlusion of intradural cerebral aneurysms.
Topics: Adult; Aged; Angioplasty; Biocompatible Materials; Brain Edema; Cohort Studies; Embolization, Therap | 2008 |
Hypothermia reduces cytotoxic edema and metabolic alterations during the acute phase of massive SAH: a diffusion-weighted imaging and spectroscopy study in rats.
Topics: Acute Disease; Animals; Aspartic Acid; Body Temperature; Brain; Brain Edema; Cerebral Cortex; Creati | 2008 |
Acute subdural hematoma in pigs: role of volume on multiparametric neuromonitoring and histology.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Evoked Potentials, Somatosensor | 2008 |
Changes in cerebral oxygen consumption and high-energy phosphates during early recovery in hypoxic-ischemic piglets: a combined near-infrared and magnetic resonance spectroscopy study.
Topics: Animals; Animals, Newborn; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Disease Models, | 2009 |
Delayed cerebral oxidative glucose metabolism after traumatic brain injury in young rats.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Edema; Brain Injuries; Glucose; Glutamic Acid; Glutamine; | 2009 |
Metabolic alterations in the peritumoral brain in cases of meningiomas: 1H-MRS study.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Edema; Choline; Female; Humans; Lactic Acid; Lipids; Magnet | 2009 |
Temporal and regional changes after focal traumatic brain injury.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Brain Injuries; Brain Mapping; Cerebral Cortex; Choline; | 2010 |
Diffusion tensor imaging supports the cytotoxic origin of brain edema in a rat model of acute liver failure.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain; Brain Edema; Diffusion Tensor Imaging; Glu | 2010 |
Cerebral metabolic alterations in rats with diabetic ketoacidosis: effects of treatment with insulin and intravenous fluids and effects of bumetanide.
Topics: Animals; Aspartic Acid; Brain; Brain Edema; Bumetanide; Cerebrovascular Circulation; Creatinine; Dia | 2010 |
Multiple therapeutic effects of adjunctive baicalin therapy in experimental bacterial meningitis.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Blood Pressure; Brain Edema; Cere | 2010 |
Fatal cerebral edema associated with serine deficiency in CSF.
Topics: Biomarkers; Blood Glucose; Brain; Brain Edema; Child; Child, Preschool; Energy Metabolism; Fatal Out | 2010 |
Brain energy metabolism in patients with spontaneous subarachnoid hemorrhage and global cerebral edema.
Topics: Biomarkers; Brain; Brain Chemistry; Brain Edema; Energy Metabolism; Extracellular Fluid; Glucose; Hu | 2010 |
Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure.
Topics: Adolescent; Adult; Brain; Brain Edema; Female; Humans; Hyperammonemia; Hypoxanthine; Inosine; Intrac | 2010 |
Metabolic effects of a late hypotensive insult combined with reduced intracranial compliance following traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Glycerol; Hypotension; Hypoxant | 2010 |
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain Edema; Capillary Permeability; Cerebellum; Cerebrum; En | 2011 |
Prostacyclin infusion may prevent secondary damage in pericontusional brain tissue.
Topics: Blood Glucose; Brain Concussion; Brain Damage, Chronic; Brain Edema; Brain Ischemia; Epoprostenol; F | 2011 |
Global cerebral edema and brain metabolism after subarachnoid hemorrhage.
Topics: Brain; Brain Edema; Female; Glucose; Humans; Lactic Acid; Middle Aged; Oxygen; Prospective Studies; | 2011 |
Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats.
Topics: Animals; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relatio | 2011 |
Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.
Topics: Animals; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Evoked Po | 2011 |
Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain Edema; Cerebrum; Diabetes Mellitus, Experiment | 2012 |
An energy-failure based brain edema concept.
Topics: Acidosis, Lactic; Animals; Brain Edema; Energy Metabolism; Glucose; Humans; Lactic Acid; Models, Neu | 2012 |
Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3K/Akt pathway.
Topics: Animals; Brain Edema; Brain Infarction; Chromones; Energy Metabolism; Enzyme Inhibitors; L-Lactate D | 2013 |
Cerebral physiological and biochemical changes during vasogenic brain oedema induced by intrathecal injection of bacterial lipopolysaccharides in piglets.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Escherichia coli; Glucose; Inflammation; Intrac | 2002 |
Long-time microdialysis in a patient with meningoencephalitis.
Topics: Adult; Brain Edema; Combined Modality Therapy; Diuretics, Osmotic; Glucose; Glutamic Acid; Glycerol; | 2002 |
Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study.
Topics: Amino Acids; Ammonia; Animals; Blood; Body Water; Brain; Brain Edema; Carbon Isotopes; Glucose; Hepa | 2003 |
Effects of ganglioside GM1 on reduction of brain edema and amelioration of cerebral metabolism after traumatic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Hexosyltransferases; Lactic Aci | 2003 |
Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.
Topics: Ammonia; Brain; Brain Edema; Glutamic Acid; Humans; Hypothermia, Induced; Lactic Acid; Liver Failure | 2002 |
Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.
Topics: Amino Acids; Animals; Brain Edema; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Cerebral | 2003 |
Moderate controlled cortical contusion in pigs: effects on multi-parametric neuromonitoring and clinical relevance.
Topics: Animals; Body Temperature; Brain Edema; Brain Injuries; Disease Models, Animal; Glucose; Glutamic Ac | 2003 |
[Cerebral microdialysis in stroke].
Topics: Brain Edema; Critical Care; Diagnostic Imaging; Electrolytes; Energy Metabolism; Glutamic Acid; Glyc | 2004 |
Neurochemical monitoring of glycerol therapy in patients with ischemic brain edema.
Topics: Adult; Aged; Brain; Brain Edema; Drug Monitoring; Edema; Female; Glutamic Acid; Glycerol; Humans; In | 2005 |
Proton MRS of the peritumoral brain.
Topics: Adult; Aspartic Acid; Biomarkers, Tumor; Brain; Brain Edema; Brain Neoplasms; Epilepsy; Female; Huma | 2005 |
MRL/lpr mice have alterations in brain metabolism as shown with [1H-13C] NMR spectroscopy.
Topics: Alanine; Amino Acids; Animals; Brain; Brain Diseases, Metabolic; Brain Edema; Carbon Radioisotopes; | 2005 |
[Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
Topics: Animals; Brain Edema; Brain Injuries; Hypothermia, Induced; Lactic Acid; Male; Random Allocation; Ra | 2004 |
Low intracranial compliance increases the impact of intracranial volume insults to the traumatized brain: a microdialysis study in a traumatic brain injury rodent model.
Topics: Animals; Biomarkers; Brain; Brain Chemistry; Brain Edema; Brain Injuries; Cell Membrane; Cerebral He | 2006 |
Serial MR imaging, diffusion tensor imaging, and MR spectroscopic findings in a child with progressive encephalopathy, edema, hypsarrhythmia, and optic atrophy (PEHO) syndrome.
Topics: Aspartic Acid; Atrophy; Brain Diseases; Brain Edema; Cerebellum; Child; Choline; Creatine; Diffusion | 2006 |
High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure.
Topics: Adolescent; Adult; Astrocytes; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Cran | 2000 |
Identification and clinical impact of impaired cerebrovascular autoregulation in patients with malignant middle cerebral artery infarction.
Topics: Blood Pressure; Brain; Brain Edema; Cerebrovascular Circulation; Disease Progression; Energy Metabol | 2007 |
Is it worthwhile to use cerebral microdialysis in patients with acute liver failure?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Bra | 2006 |
Microdialysis in the management of hepatic encephalopathy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Blood Glucose; Brain; Brain Edema; Critical Care; Dextropro | 2006 |
Posttraumatic brain vulnerability to hypoxia-hypotension: the importance of the delay between brain trauma and secondary insult.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; Gl | 2008 |
Perianeurysm edema with second-generation bioactive coils.
Topics: Adult; Biocompatible Materials; Brain Edema; Embolization, Therapeutic; Female; Humans; Intracranial | 2008 |
Cerebral glutamine concentration and lactate-pyruvate ratio in patients with acute liver failure.
Topics: Adolescent; Adult; Aged; Astrocytes; Brain; Brain Edema; Critical Care; Female; Glutamine; Humans; H | 2008 |
[Studies on pathogenesis of cerebral edema due to experimental cerebral hemorrhage. An approach through energy metabolism (author's transl)].
Topics: Adenosine Monophosphate; Animals; Body Water; Brain; Brain Edema; Cerebral Hemorrhage; Cyclic AMP; E | 1982 |
Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain; Brain Edema; Brain Ischemia; Dexamethasone; Dose-Re | 1984 |
Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.
Topics: Animals; Brain Edema; Cerebral Cortex; Dimethyl Sulfoxide; Free Radicals; Lactates; Lactic Acid; Lip | 1982 |
Beneficial effect of CV-4151 (Isbogrel), a thromboxane A2 synthase inhibitor, in a rat middle cerebral artery thrombosis model.
Topics: Animals; Aspirin; Brain Chemistry; Brain Edema; Cerebral Arteries; Cerebral Infarction; Drug Evaluat | 1995 |
Localised proton spectroscopy and spectroscopic imaging in cerebral gliomas, with comparison to positron emission tomography.
Topics: Aspartic Acid; Brain; Brain Chemistry; Brain Edema; Carbon Radioisotopes; Creatine; Deoxyglucose; Fl | 1995 |
The role of bradykinin in mediating ischemic brain edema in rats.
Topics: Adenosine Triphosphate; Animals; Aprotinin; Blood Pressure; Body Water; Bradykinin; Brain; Brain Ede | 1993 |
[Protective effect of dexamethasone and phenytoin in the treatment of experimental pneumococcal meningitis].
Topics: Animals; Brain Edema; Cerebrospinal Fluid Proteins; Dexamethasone; Lactates; Lactic Acid; Leukocyte | 1995 |
Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection.
Topics: Animals; Arthritis, Infectious; Brain Edema; Cerebrospinal Fluid Proteins; Haemophilus Infections; H | 1995 |
Neurochemical monitoring and on-line pH measurements using brain microdialysis in patients in intensive care.
Topics: Acid-Base Equilibrium; Adult; Ascorbic Acid; Blood Glucose; Blood-Brain Barrier; Brain Edema; Brain | 1994 |
Brain lactate and pH dissociation in edema: 1H- and 31P-NMR in collagenase-induced hemorrhage in rats.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Collagenases; Hydrogen-Ion Concentration; Lactates | 1993 |
Effects of asphyxia on the fetal lamb brain.
Topics: Animals; Blood Pressure; Brain; Brain Edema; Cerebellum; Cerebrovascular Circulation; Female; Fetal | 1993 |
Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Brain; Brain Edema; Carbon Dioxide; Co | 1994 |
Fluid administration, brain edema, and cerebrospinal fluid lactate and glucose concentrations in experimental Escherichia coli meningitis.
Topics: Animals; Brain Edema; Escherichia coli Infections; Fluid Therapy; Glucose; Lactates; Lactic Acid; Me | 1993 |
Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome.
Topics: Animals; Antifungal Agents; Antigens, Fungal; Brain Edema; Cryptococcus neoformans; Drug Therapy, Co | 1996 |
Swelling, intracellular acidosis, and damage of glial cells.
Topics: Acid-Base Equilibrium; Animals; Arachidonic Acid; Brain Damage, Chronic; Brain Edema; Brain Ischemia | 1996 |
Dissociation between lactate accumulation and acidosis in middle cerebral artery-occluded rats assessed by 31P and 1H NMR metabolic images under a 2-T magnetic field.
Topics: Acidosis; Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Hydrogen-Ion Concentrati | 1996 |
Significance of multimodal cerebral monitoring under moderate therapeutic hypothermia for severe head injury.
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Brain; Brain Edema; Brain Injuries; Child; Child, Pres | 1998 |
In vivo 1H MR spectroscopic imaging and diffusion weighted MRI in experimental hydrocephalus.
Topics: Acute Disease; Analysis of Variance; Animals; Brain; Brain Edema; Brain Ischemia; Chronic Disease; D | 1998 |
Neurochemical monitoring of fatal middle cerebral artery infarction.
Topics: Adult; Biomarkers; Brain Edema; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Fatal Outco | 1999 |
Does growth hormone augment brain edema caused by brain injury? A study with a freeze brain injury model in the rat.
Topics: Animals; Blood Glucose; Body Water; Brain Chemistry; Brain Edema; Brain Injuries; Disease Models, An | 1999 |
Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury.
Topics: Aspartic Acid; Brain Edema; Chi-Square Distribution; Child; Child, Preschool; Discriminant Analysis; | 2000 |
Metabolic changes in pericontusional oedematous areas in mild head injury evaluated by 1H MRS.
Topics: Adolescent; Adult; Aged; Aspartic Acid; Brain; Brain Concussion; Brain Edema; Brain Ischemia; Creati | 2000 |
1H-MR spectroscopic monitoring of posttraumatic metabolism following controlled cortical impact injury: pilot study.
Topics: Animals; Aspartic Acid; Brain Concussion; Brain Edema; Cerebral Cortex; Choline; Creatine; Energy Me | 2000 |
Interstitial lactate in the peritraumatic penumbra of rat brain.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Lactic Acid; Male; Nec | 2000 |
Evidence for lactate uptake after rat fluid percussion brain injury.
Topics: Animals; Autoradiography; Blood Glucose; Brain; Brain Concussion; Brain Edema; Glycolysis; Lactic Ac | 2000 |
Low extracellular (ECF) glucose affects the neurochemical profile in severe head-injured patients.
Topics: Blood Glucose; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Critical Care; Energy Metabolism; | 2000 |
Substrate delivery and ionic balance disturbance after severe human head injury.
Topics: Acid-Base Equilibrium; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Glutamic Acid; Humans; La | 2000 |
Clinical spectrum of reversible posterior leukoencephalopathy syndrome.
Topics: Adolescent; Adult; Blood-Brain Barrier; Brain Edema; Child; Child, Preschool; Cyclosporine; Diagnosi | 2001 |
Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats.
Topics: 3-Hydroxybutyric Acid; Adenosine Triphosphate; Animals; Blood Pressure; Body Water; Brain; Brain Ede | 2001 |
Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.
Topics: Ammonia; Animals; Brain; Brain Edema; Energy Metabolism; Hepatic Encephalopathy; Hypothermia, Induce | 2001 |
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M | 2002 |
Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Brain Edema; CD18 Antigens; Combined Modality Therapy | 1991 |
Time course of CSF lactate level in subarachnoid haemorrhage. Correlation with clinical grading and prognosis.
Topics: Acid-Base Equilibrium; Adult; Aged; Brain Edema; Brain Ischemia; Coma; Electrolytes; Female; Humans; | 1989 |
The protective effect of mannitol, vitamin E and glucocorticoid on ischaemic brain injury: evaluation by chemiluminescence, energy metabolism and water content.
Topics: Adenine Nucleotides; Animals; Body Water; Brain Edema; Carbohydrate Metabolism; Drug Combinations; E | 1988 |
[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage].
Topics: Animals; Brain; Brain Edema; Carbohydrate Metabolism; Cats; Cerebral Hemorrhage; Cerebrovascular Cir | 1988 |
Influence of granulocytes on brain edema, intracranial pressure, and cerebrospinal fluid concentrations of lactate and protein in experimental meningitis.
Topics: Animals; Brain Edema; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Granulocytes; Intracranial | 1988 |
Dexamethasone in the treatment of experimental Haemophilus influenzae type b meningitis.
Topics: Animals; Brain Edema; Ceftriaxone; Cerebrospinal Fluid; Dexamethasone; Drug Therapy, Combination; Ha | 1987 |
[Involvement of arachidonic acid cascade in brain edema and cerebral energy metabolism after reperfusion].
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Body Water; Brain; Brain Edema; Dexamethasone; E | 1987 |
Effects of ampicillin and corticosteroids on brain water content, cerebrospinal fluid pressure, and cerebrospinal fluid lactate levels in experimental pneumococcal meningitis.
Topics: Adrenal Cortex Hormones; Ampicillin; Animals; Body Water; Brain Chemistry; Brain Edema; Dexamethason | 1985 |