lactic acid has been researched along with Brain Dead in 28 studies
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The authors' goal was to characterize patterns of markers of energy metabolism (glucose, pyruvate, and lactate) and neuronal injury (glutamate and glycerol) in patients with subarachnoid hemorrhage (SAH), in whom ischemia was or was not suspected." | 5.09 | Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage. ( Bjerre, P; Schulz, MK; Tange, M; Wang, LP, 2000) |
| " Reflexes disappeared, and atropine did not induce an increase in heart rate in the brain dead animals." | 3.78 | Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography. ( Andersen, G; Barklin, A; Hvas, CL; Nielsen, TK; Pedersen, M; Sørensen, JC; Tønnesen, E, 2012) |
| "Thyrotropin levels increased from brain death to extraction procedure in controls." | 2.71 | Efficiency of triiodothyronine treatment on organ donor hemodynamic management and adenine nucleotide concentration. ( Cánovas-Robles, J; Caturla-Such, J; Pérez-Blanco, A; Sanchez-Payá, J, 2005) |
| "Histological features of ischaemia and reperfusion injury were assessed." | 1.40 | Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion. ( Ahmed, N; Mirza, DF; Murphy, N; Neil, DA; Perera, MT; Richards, DA; Silva, MA, 2014) |
| "Early brain death (within 48 h) was assumed to be due to early global ischemia." | 1.34 | Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences. ( Chieregato, A; Fainardi, E; Marchi, M; Targa, L, 2007) |
| "It is debated whether brain death (BD) causes transient functional ischemia." | 1.33 | Brain death does not change epicardial action potentials and their response to ischemia-reperfusion in open-chest pigs. ( Christé, G; Ferrera, R; Hadour, G; Ovize, M, 2006) |
| "Coronary flow reserve in the same brain death model was assessed by changes in coronary flow and resistance induced by administering a vasodilator directly into the coronary artery in another eight dogs." | 1.32 | Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart. ( Imasaka, K; Kajihara, N; Masuda, M; Morita, S; Nishimura, Y; Oishi, Y; Yasui, H, 2003) |
| "One minute after brain death, the Cushing reflex appeared, with a hyperdynamic response to plasma catecholamines levels increasing (norepinephrine and epinephrine, 3." | 1.31 | Biphasic response after brain death induction: prominent part of catecholamines release in this phenomenon. ( Budat, C; Chiari, P; Ferrera, R; Hadour, G; Jegaden, O; Lehot, JJ; Michel, P; Ovize, M; Piriou, V; Rodriguez, C, 2000) |
| "Myocardial ischemia has been suggested as a possible cause." | 1.31 | Evidence of functional myocardial ischemia associated with myocardial dysfunction in brain-dead pigs. ( de Talancé, N; Devaux, Y; Grosjean, S; Mairose, P; Mertes, PM; Seguin, C; Siaghy, EM; Ungureanu-Longrois, D; Zannad, F, 2001) |
| "After brain death, a transient increase in heart rate (from 90 [67-120] to 158 [120-200] beats/min) (median, with range in brackets), MAP (82 [74-103] to 117 [85-142] mmHg), LV dP/dtmax (1750 [1100-2100] to 5150 [4000-62,000] mmHg x sec(-1), rate-pressure product (9100 [7700-9700] beats mmHg/min to 22,750 [20,000-26,000] beats mmHg/min), CO (2." | 1.30 | Increase in myocardial interstitial adenosine and net lactate production in brain-dead pigs: an in vivo microdialysis study. ( Beck, B; Burlet, C; Devaux, Y; Halejcio-Delophont, P; Mertes, PM; Richoux, JP; Siaghy, EM; Ungureanu-Longrois, D; Villemot, JP, 1998) |
| "At end-point (7 h post brain death) arterial concentrations and myocardial arteriovenous (a-v) concentration differences of glucose, lactate and free fatty acids (FFA) were assessed, and myocardial biopsy specimens were taken from the right atrium and left ventricle." | 1.29 | Glucose-insulin-potassium (GIK) prevents derangement of myocardial metabolism in brain-dead pigs. ( Berggren, H; Ekroth, R; Mantovani, V; Nilsson, B; Nilsson, F; Svensson, S; Wiklund, L, 1994) |
| "We conclude that brain death leads to early impaired left ventricular contractility, which could be responsible for the changes observed in aerobic to anaerobic metabolism in response to rapid volume infusion." | 1.29 | Changes in hemodynamic and metabolic parameters following induced brain death in the pig. ( Boulange, M; Burlet, C; Burtin, P; Carteaux, JP; el Abassi, K; Jaboin, Y; Mertes, PM; Pinelli, G; Villemot, JP, 1994) |
| "We conclude that brain death was associated with a low VO2, and patients in group HL exhibited DO2/VO2 dependency which was not observed in patients in group NL." | 1.29 | Oxygen consumption and delivery relationship in brain-dead organ donors. ( Coriat, P; Couture, P; Langeron, O; Mateo, J; Pansard, JL; Riou, B, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.14) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Hann, A | 1 |
| Lembach, H | 1 |
| Nutu, A | 1 |
| Mergental, H | 1 |
| Isaac, JL | 1 |
| Isaac, JR | 1 |
| Oo, YH | 1 |
| Armstrong, MJ | 1 |
| Rajoriya, N | 1 |
| Afford, S | 1 |
| Bartlett, D | 1 |
| Mirza, DF | 2 |
| Hartog, H | 1 |
| Perera, MTPR | 1 |
| Baroncelli, F | 1 |
| Alberione, MC | 1 |
| Cacciotti, V | 1 |
| Artusio, D | 1 |
| Vergano, M | 1 |
| Livigni, S | 1 |
| Grand, J | 1 |
| Kjaergaard, J | 1 |
| Bro-Jeppesen, J | 1 |
| Wanscher, M | 1 |
| Nielsen, N | 1 |
| Lindholm, MG | 1 |
| Thomsen, JH | 1 |
| Boesgaard, S | 1 |
| Hassager, C | 1 |
| Perera, MT | 1 |
| Richards, DA | 1 |
| Silva, MA | 1 |
| Ahmed, N | 1 |
| Neil, DA | 1 |
| Murphy, N | 1 |
| Ryu, JA | 1 |
| Cho, YH | 1 |
| Sung, K | 1 |
| Choi, SH | 1 |
| Yang, JH | 2 |
| Choi, JH | 1 |
| Lee, DS | 1 |
| Zhu, XS | 1 |
| Wang, SS | 1 |
| Cheng, Q | 1 |
| Ye, CW | 1 |
| Huo, F | 1 |
| Li, P | 1 |
| Robert, R | 1 |
| Guilhot, J | 1 |
| Pinsard, M | 1 |
| Longeard, PL | 1 |
| Jacob, JP | 1 |
| Gissot, V | 1 |
| Hauet, T | 1 |
| Seguin, F | 1 |
| Purins, K | 1 |
| Enblad, P | 1 |
| Wiklund, L | 2 |
| Lewén, A | 1 |
| Hvas, CL | 1 |
| Nielsen, TK | 1 |
| Barklin, A | 1 |
| Sørensen, JC | 1 |
| Pedersen, M | 1 |
| Andersen, G | 1 |
| Tønnesen, E | 1 |
| Westphal, GA | 1 |
| Caldeira Filho, M | 1 |
| Fiorelli, A | 1 |
| Vieira, KD | 1 |
| Zaclikevis, V | 1 |
| Bartz, M | 1 |
| Wanzuita, R | 1 |
| Teixeira, C | 1 |
| Franke, C | 1 |
| Machado, FO | 1 |
| Friedman, G | 1 |
| Andrade, J | 1 |
| Matos, JD | 1 |
| Lamgaro, DM | 1 |
| Silva, E | 1 |
| Costa, G | 1 |
| Coelho, ME | 1 |
| Oliveira, MC | 1 |
| Youssef, NC | 1 |
| Akamine, N | 1 |
| Duarte, P | 1 |
| Lisboa, R | 1 |
| Mazzali, M | 1 |
| Ferraz Neto, BH | 1 |
| Oishi, Y | 1 |
| Nishimura, Y | 1 |
| Imasaka, K | 1 |
| Kajihara, N | 1 |
| Morita, S | 1 |
| Masuda, M | 1 |
| Yasui, H | 1 |
| Wartenberg, KE | 1 |
| Patsalides, A | 1 |
| Yepes, MS | 1 |
| Pérez-Blanco, A | 1 |
| Caturla-Such, J | 1 |
| Cánovas-Robles, J | 1 |
| Sanchez-Payá, J | 1 |
| Christé, G | 1 |
| Hadour, G | 2 |
| Ovize, M | 2 |
| Ferrera, R | 2 |
| Chieregato, A | 1 |
| Marchi, M | 1 |
| Fainardi, E | 1 |
| Targa, L | 1 |
| Schiffner, H | 1 |
| Kemmer, C | 1 |
| Kunze, KD | 1 |
| Kopprasch, S | 1 |
| Orlik, H | 1 |
| Nilsson, B | 1 |
| Berggren, H | 1 |
| Ekroth, R | 1 |
| Mantovani, V | 1 |
| Nilsson, F | 1 |
| Svensson, S | 1 |
| Mertes, PM | 4 |
| el Abassi, K | 1 |
| Jaboin, Y | 2 |
| Burtin, P | 2 |
| Pinelli, G | 2 |
| Carteaux, JP | 2 |
| Burlet, C | 3 |
| Boulange, M | 2 |
| Villemot, JP | 3 |
| Langeron, O | 1 |
| Couture, P | 1 |
| Mateo, J | 1 |
| Riou, B | 1 |
| Pansard, JL | 1 |
| Coriat, P | 1 |
| Goodman, JC | 2 |
| Gopinath, SP | 2 |
| Valadka, AB | 2 |
| Narayan, RK | 1 |
| Grossman, RG | 1 |
| Simpson, RK | 1 |
| Robertson, CS | 2 |
| Uzura, M | 1 |
| Halejcio-Delophont, P | 1 |
| Siaghy, EM | 2 |
| Devaux, Y | 2 |
| Ungureanu-Longrois, D | 2 |
| Richoux, JP | 1 |
| Beck, B | 1 |
| Chiari, P | 1 |
| Michel, P | 1 |
| Piriou, V | 1 |
| Rodriguez, C | 1 |
| Budat, C | 1 |
| Jegaden, O | 1 |
| Lehot, JJ | 1 |
| Schulz, MK | 1 |
| Wang, LP | 1 |
| Tange, M | 1 |
| Bjerre, P | 1 |
| Sztark, F | 1 |
| Thicoïpé, M | 1 |
| Lassié, P | 1 |
| Petitjean, ME | 1 |
| Dabadie, P | 1 |
| Seguin, C | 1 |
| Grosjean, S | 1 |
| Mairose, P | 1 |
| Zannad, F | 1 |
| de Talancé, N | 1 |
| Novitzky, D | 1 |
| Cooper, DK | 1 |
| Morrell, D | 1 |
| Isaacs, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant[NCT04529005] | Phase 4 | 20 participants (Actual) | Interventional | 2020-08-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of vasopressor usage while in the operating room measured in hours of usage presented as median and IQR. (NCT04529005)
Timeframe: Duration of usage during the transplant surgery - presented in hours
| Intervention | hours (Median) |
|---|---|
| Angiotensin II (Giapreza) | 1 |
The presence of arrhythmia was confirmed via EKG, flowsheet, or note documentation from the electronic medical record. (NCT04529005)
Timeframe: From date and time of study drug initiation during or after transplant operation until study drug is discontinued up to a maximum of 30 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 1 |
The presence of Delayed Graft Function was captured for each patient and defined by the need for renal replacement therapy up to 7 days post-operative. (NCT04529005)
Timeframe: From post-op to 7 days post-op
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 2 |
The presence of post-operative fungal infections were captured prior to discharge as documented by the clinical care team in the electronic medical record. (NCT04529005)
Timeframe: From date and time of study drug initiation during or after transplant operation until study drug is discontinued up to a maximum of 30 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 0 |
The presence of hyperglycemia was captured for each patient and was determined by those patients requiring the use of an insulin infusion after their transplant surgery. (NCT04529005)
Timeframe: From date and time of study drug initiation during or after transplant operation until study drug is discontinued up to a maximum of 30 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 1 |
The presence of digital or other peripheral/visceral ischemia was captured from reviewing chart documentation for each patient. (NCT04529005)
Timeframe: From date and time of study drug initiation during or after transplant operation until study drug is discontinued up to a maximum of 30 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 0 |
Incidence of venous or arterial thrombosis occurring during the hospitalization for kidney transplant (captured by ultrasound or other diagnostic imaging) (NCT04529005)
Timeframe: From date and time of study drug initiation during or after transplant operation until study drug is discontinued up to a maximum of 30 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Angiotensin II (Giapreza) | 0 |
1 review available for lactic acid and Brain Dead
| Article | Year |
|---|---|
Guidelines for maintenance of adult patients with brain death and potential for multiple organ donations: the Task Force of the Brazilian Association of Intensive Medicine the Brazilian Association of Organs Transplantation, and the Transplantation Center
Topics: Adult; Biomarkers; Blood Pressure; Blood Pressure Determination; Blood Volume; Body Temperature; Bra | 2012 |
3 trials available for lactic acid and Brain Dead
| Article | Year |
|---|---|
Cardiac output, heart rate and stroke volume during targeted temperature management after out-of-hospital cardiac arrest: Association with mortality and cause of death.
Topics: Aged; Arterial Pressure; Brain Death; Cardiac Output; Cardiopulmonary Resuscitation; Cause of Death; | 2019 |
Efficiency of triiodothyronine treatment on organ donor hemodynamic management and adenine nucleotide concentration.
Topics: Adenine Nucleotides; Adult; Blood Pressure; Brain Death; Cardiac Output; Double-Blind Method; Humans | 2005 |
Cerebral microdialysis monitoring: determination of normal and ischemic cerebral metabolisms in patients with aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Death; Brain Ischemia; Cerebral Angiography; Extracellular Space; Glucose; | 2000 |
24 other studies available for lactic acid and Brain Dead
| Article | Year |
|---|---|
Assessment of Deceased Brain Dead Donor Liver Grafts via Normothermic Machine Perfusion: Lactate Clearance Time Threshold Can Be Safely Extended to 6 Hours.
Topics: Brain Death; Humans; Lactic Acid; Liver; Liver Transplantation; Living Donors; Organ Preservation; P | 2022 |
Blood Lactate Concentrations Before and After Withdrawal of Life-Sustaining Treatments in Controlled Donation After Circulatory Death: A Case Report From Italy.
Topics: Brain Death; Female; Humans; Italy; Lactic Acid; Middle Aged; Organ Preservation; Perfusion; Tissue | 2017 |
Comparison of energy metabolism in liver grafts from donors after circulatory death and donors after brain death during cold storage and reperfusion.
Topics: Adult; Aged; Brain Death; Cryopreservation; Energy Metabolism; Glycerol; Graft Survival; Heart Arres | 2014 |
Predictors of neurological outcomes after successful extracorporeal cardiopulmonary resuscitation.
Topics: Aged; Brain; Brain Death; Cardiopulmonary Resuscitation; Extracorporeal Membrane Oxygenation; Female | 2015 |
Using ultrasonography to monitor liver blood flow for liver transplant from donors supported on extracorporeal membrane oxygenation.
Topics: Adolescent; Adult; Alanine Transaminase; Bilirubin; Blood Flow Velocity; Brain Death; Calibration; C | 2016 |
A pair analysis of the delayed graft function in kidney recipient: the critical role of the donor.
Topics: Adolescent; Adult; Age Factors; Aged; Biomarkers; Brain Death; Child; Citric Acid; Delayed Graft Fun | 2010 |
Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.
Topics: Animals; Blood Pressure; Brain; Brain Death; Brain Injuries; Brain Ischemia; Catheterization; Cerebr | 2012 |
Brain death induced by cerebral haemorrhage - a new porcine model evaluated by CT angiography.
Topics: Animals; Arterial Pressure; Atropine; Blood Gas Analysis; Brain Death; Cardiac Output; Cerebral Angi | 2012 |
Impairment of coronary flow reserve and left ventricular function in the brain-dead canine heart.
Topics: Animals; Brain Death; Coronary Circulation; Disease Models, Animal; Dogs; Hemodynamics; Lactic Acid; | 2003 |
Is magnetic resonance spectroscopy superior to conventional diagnostic tools in hypoxic-ischemic encephalopathy?
Topics: Aspartic Acid; Brain; Brain Death; Cell Death; Choline; Coma; Creatine; Diffusion Magnetic Resonance | 2004 |
Brain death does not change epicardial action potentials and their response to ischemia-reperfusion in open-chest pigs.
Topics: Action Potentials; Animals; Arteries; Blood Pressure; Brain Death; Heart Rate; Heart Ventricles; Hem | 2006 |
Cerebral arterio-venous pCO2 difference, estimated respiratory quotient, and early posttraumatic outcome: comparison with arterio-venous lactate and oxygen differences.
Topics: Adult; Brain Death; Brain Injuries; Brain Ischemia; Carbon Dioxide; Cerebrovascular Circulation; Fem | 2007 |
[Biochemical and ultrastructural changes of the liver during the loss of cerebral function].
Topics: Adenine Nucleotides; Animals; Brain Death; Dogs; Endoplasmic Reticulum; Lactates; Lactic Acid; Liver | 1984 |
Glucose-insulin-potassium (GIK) prevents derangement of myocardial metabolism in brain-dead pigs.
Topics: Animals; Blood Glucose; Brain Death; Cardioplegic Solutions; Energy Metabolism; Fatty Acids, Noneste | 1994 |
Changes in hemodynamic and metabolic parameters following induced brain death in the pig.
Topics: Animals; Atrial Natriuretic Factor; Brain; Brain Death; Disease Models, Animal; Hemodynamics; Lactat | 1994 |
Changes in hemodynamic performance and oxygen consumption during brain death in the pig.
Topics: Anaerobiosis; Animals; Brain Death; Heart Transplantation; Hemodynamics; Lactates; Lactic Acid; Orga | 1994 |
Oxygen consumption and delivery relationship in brain-dead organ donors.
Topics: Adolescent; Adult; Brain Death; Female; Gravity Suits; Humans; Lactates; Lactic Acid; Male; Middle A | 1996 |
Lactic acid and amino acid fluctuations measured using microdialysis reflect physiological derangements in head injury.
Topics: Adult; Amino Acids; Brain; Brain Death; Craniocerebral Trauma; Extracellular Space; Humans; Intracra | 1996 |
Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans.
Topics: Adult; Brain; Brain Death; Brain Injuries; Cations; Chromatography, High Pressure Liquid; Excitatory | 1998 |
Increase in myocardial interstitial adenosine and net lactate production in brain-dead pigs: an in vivo microdialysis study.
Topics: Adenosine; Animals; Blood Gas Analysis; Brain Death; Hemodynamics; Lactic Acid; Microdialysis; Myoca | 1998 |
Biphasic response after brain death induction: prominent part of catecholamines release in this phenomenon.
Topics: Animals; Biomarkers; Brain Death; Catecholamines; Catheterization; Chromatography, High Pressure Liq | 2000 |
Mitochondrial energy metabolism in brain-dead organ donors.
Topics: Adenosine Triphosphate; Adult; Brain Death; Case-Control Studies; Energy Metabolism; Female; Humans; | 2000 |
Evidence of functional myocardial ischemia associated with myocardial dysfunction in brain-dead pigs.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Brain Death; Cardiac Ou | 2001 |
Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine therapy.
Topics: Aerobiosis; Anaerobiosis; Animals; Brain Death; Energy Metabolism; Fatty Acids, Nonesterified; Gluco | 1988 |